ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	9.93451237
2	sensory perception of taste (GO:0050909)	8.95599967
3	long term synaptic depression (GO:0060292)	8.56001695
4	synaptic transmission, dopaminergic (GO:0001963)	8.55832261
5	male meiosis I (GO:0007141)	7.39424225
6	DNA methylation involved in gamete generation (GO:0043046)	7.21534705
7	chromosome organization involved in meiosis (GO:0070192)	7.17314894
8	transmission of nerve impulse (GO:0019226)	7.10546875
9	piRNA metabolic process (GO:0034587)	7.09034492
10	multicellular organismal reproductive behavior (GO:0033057)	7.08225982
11	DNA synthesis involved in DNA repair (GO:0000731)	6.77142810
12	male meiosis (GO:0007140)	6.64489719
13	negative regulation by host of viral transcription (GO:0043922)	6.49024424
14	meiosis I (GO:0007127)	6.30036541
15	synaptonemal complex assembly (GO:0007130)	6.17504510
16	synaptonemal complex organization (GO:0070193)	5.87274460
17	negative regulation of oxidoreductase activity (GO:0051354)	5.44114657
18	meiotic nuclear division (GO:0007126)	5.30087869
19	multi-organism reproductive behavior (GO:0044705)	5.24339190
20	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	5.22924325
21	endocrine process (GO:0050886)	5.22924325
22	regulation of systemic arterial blood pressure by hormone (GO:0001990)	5.22924325
23	regulation of hydrogen peroxide metabolic process (GO:0010310)	5.18203899
24	meiotic chromosome segregation (GO:0045132)	5.07584129
25	reproductive behavior (GO:0019098)	5.03363339
26	sensory perception of chemical stimulus (GO:0007606)	4.84630634
27	cellular response to monoamine stimulus (GO:0071868)	4.82552713
28	cellular response to catecholamine stimulus (GO:0071870)	4.82552713
29	response to catecholamine (GO:0071869)	4.31214416
30	response to monoamine (GO:0071867)	4.31214416
31	regulation of systemic arterial blood pressure (GO:0003073)	4.15958075
32	meiotic cell cycle process (GO:1903046)	4.05600236
33	modulation by host of symbiont transcription (GO:0052472)	3.98814686
34	modulation by host of viral transcription (GO:0043921)	3.98814686
35	reciprocal DNA recombination (GO:0035825)	3.95164573
36	reciprocal meiotic recombination (GO:0007131)	3.95164573
37	dopamine receptor signaling pathway (GO:0007212)	3.89331874
38	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	3.82597347
39	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.73162425
40	response to amphetamine (GO:0001975)	3.73076294
41	sister chromatid cohesion (GO:0007062)	3.65198937
42	negative regulation of inclusion body assembly (GO:0090084)	3.46815013
43	histone H3-K36 demethylation (GO:0070544)	3.46200481
44	actin filament capping (GO:0051693)	3.43109763
45	activation of adenylate cyclase activity (GO:0007190)	3.39842369
46	cardiolipin metabolic process (GO:0032048)	3.37203623
47	relaxation of smooth muscle (GO:0044557)	3.35483592
48	regulation of ARF protein signal transduction (GO:0032012)	3.30084264
49	protein-chromophore linkage (GO:0018298)	3.25439628
50	positive regulation of vascular permeability (GO:0043117)	3.21380354
51	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.17810905
52	vesicle targeting (GO:0006903)	3.17726341
53	multicellular organismal signaling (GO:0035637)	3.17560780
54	histone H3-K9 demethylation (GO:0033169)	3.14322854
55	DNA methylation (GO:0006306)	3.11111234
56	DNA alkylation (GO:0006305)	3.11111234
57	attachment of spindle microtubules to kinetochore (GO:0008608)	3.10169457
58	negative regulation of glial cell proliferation (GO:0060253)	3.09219924
59	microtubule severing (GO:0051013)	3.06979097
60	positive regulation of protein homooligomerization (GO:0032464)	3.05327316
61	regulation of gonadotropin secretion (GO:0032276)	2.97927005
62	vasoconstriction (GO:0042310)	2.96695442
63	negative regulation of myotube differentiation (GO:0010832)	2.94946951
64	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.88368659
65	positive regulation of adenylate cyclase activity (GO:0045762)	2.86576531
66	mitotic sister chromatid cohesion (GO:0007064)	2.81424180
67	phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)	2.81206270
68	response to cocaine (GO:0042220)	2.78787301
69	negative regulation of actin filament depolymerization (GO:0030835)	2.78139866
70	positive regulation of cellular response to oxidative stress (GO:1900409)	2.76594223
71	positive regulation of response to oxidative stress (GO:1902884)	2.76594223
72	negative regulation of synaptic transmission (GO:0050805)	2.72925385
73	gene silencing by RNA (GO:0031047)	2.70237861
74	negative regulation of macroautophagy (GO:0016242)	2.64823511
75	viral entry into host cell (GO:0046718)	2.63701309
76	proline biosynthetic process (GO:0006561)	2.63601404
77	negative regulation of viral transcription (GO:0032897)	2.61919595
78	fusion of sperm to egg plasma membrane (GO:0007342)	2.61173473
79	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.60813859
80	regulation of transcription from RNA polymerase I promoter (GO:0006356)	2.60252642
81	termination of G-protein coupled receptor signaling pathway (GO:0038032)	2.60225508
82	female gamete generation (GO:0007292)	2.58607534
83	fertilization (GO:0009566)	2.58020813
84	inner ear morphogenesis (GO:0042472)	2.56041038
85	regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	2.55153990
86	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.51574532
87	negative regulation of blood pressure (GO:0045776)	2.49265166
88	wound healing (GO:0042060)	2.47711132
89	protein localization to chromosome (GO:0034502)	2.45995212
90	positive regulation of cyclase activity (GO:0031281)	2.43146144
91	nephron tubule formation (GO:0072079)	2.41912102
92	tricarboxylic acid cycle (GO:0006099)	2.41708359
93	deoxyribonucleotide catabolic process (GO:0009264)	2.40579701
94	regulation of actin filament depolymerization (GO:0030834)	2.39425926
95	modification by host of symbiont morphology or physiology (GO:0051851)	2.37996336
96	response to amine (GO:0014075)	2.37503595
97	regulation of female receptivity (GO:0045924)	19.2363147
98	female mating behavior (GO:0060180)	16.8756244
99	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	12.5721104
100	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	10.8192632

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.98306155
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.46696063
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.37655634
4	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.90504497
5	RNF2_27304074_Chip-Seq_NSC_Mouse	2.90135639
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.88189091
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.68211008
8	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.39379701
9	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.39214380
10	TP53_22573176_ChIP-Seq_HFKS_Human	2.38474031
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.31483824
12	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.29989504
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.27255426
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.20567734
15	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	2.15464679
16	CTCF_27219007_Chip-Seq_Bcells_Human	2.05357772
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03667658
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84844253
19	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.81908167
20	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.81741989
21	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.75256491
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.72116400
23	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.67089750
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.65577677
25	LXR_22292898_ChIP-Seq_THP-1_Human	1.62585568
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56826247
27	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.54758870
28	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.53455377
29	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.51468933
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.51046764
31	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.49022363
32	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.48302634
33	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.46819502
34	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.45447273
35	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.44625565
36	FUS_26573619_Chip-Seq_HEK293_Human	1.41140409
37	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.40376863
38	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.37940142
39	SA1_27219007_Chip-Seq_Bcells_Human	1.36304811
40	E2F1_20622854_ChIP-Seq_HELA_Human	1.35880525
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32551193
42	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.30680967
43	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.29878238
44	OCT4_20526341_ChIP-Seq_ESCs_Human	1.25897246
45	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.25438800
46	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.24372539
47	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	1.24073948
48	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.24027655
49	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.23883348
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.22704753
51	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.20924865
52	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.18186813
53	BCL6_27268052_Chip-Seq_Bcells_Human	1.17991990
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17297071
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17297071
56	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17294345
57	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.15993344
58	RAC3_21632823_ChIP-Seq_H3396_Human	1.14489887
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.14409301
60	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12552686
61	ERA_21632823_ChIP-Seq_H3396_Human	1.12430899
62	SMC4_20622854_ChIP-Seq_HELA_Human	1.12262540
63	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10391571
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.09435398
65	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.08934625
66	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.08320061
67	SOX2_21211035_ChIP-Seq_LN229_Human	1.08221205
68	PHF8_20622854_ChIP-Seq_HELA_Human	1.08183105
69	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07838288
70	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07838288
71	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06070082
72	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.05919125
73	STAT1_20625510_ChIP-Seq_HELA_Human	1.03887098
74	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.03741821
75	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01783141
76	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00963961
77	P68_20966046_ChIP-Seq_HELA_Human	1.00890369
78	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.00659179
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.98933965
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98092929
81	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.97597412
82	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94869520
83	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.94558799
84	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93753559
85	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93111260
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91492667
87	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.89209121
88	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.88056387
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.86800426
90	AR_25329375_ChIP-Seq_VCAP_Human	0.86188113
91	PHF8_20622853_ChIP-Seq_HELA_Human	0.85988413
92	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.85101685
93	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.85064292
94	CBP_21632823_ChIP-Seq_H3396_Human	0.84743986
95	NFYB_21822215_ChIP-Seq_K562_Human	0.82974287
96	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.82167145
97	SPI1_20517297_ChIP-Seq_HL60_Human	0.81975227
98	TBL1_22424771_ChIP-Seq_293T_Human	0.81261388
99	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.81239420
100	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.81002343

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	6.94924812
2	MP0004858_abnormal_nervous_system	6.74488169
3	MP0001986_abnormal_taste_sensitivity	5.93186911
4	MP0003879_abnormal_hair_cell	4.54259839
5	MP0002909_abnormal_adrenal_gland	4.53731630
6	MP0003123_paternal_imprinting	4.44524579
7	MP0006276_abnormal_autonomic_nervous	3.98385264
8	MP0003136_yellow_coat_color	3.83040027
9	MP0008877_abnormal_DNA_methylation	3.57926694
10	MP0005423_abnormal_somatic_nervous	3.52413689
11	MP0008004_abnormal_stomach_pH	3.20432941
12	MP0009780_abnormal_chondrocyte_physiolo	2.72488835
13	MP0003787_abnormal_imprinting	2.65714744
14	MP0002132_abnormal_respiratory_system	2.25831944
15	MP0009046_muscle_twitch	2.23698425
16	MP0001661_extended_life_span	2.21711179
17	MP0002102_abnormal_ear_morphology	2.12063512
18	MP0004885_abnormal_endolymph	2.04994752
19	MP0002210_abnormal_sex_determination	1.95506553
20	MP0000383_abnormal_hair_follicle	1.73875189
21	MP0002163_abnormal_gland_morphology	1.64257289
22	MP0000026_abnormal_inner_ear	1.63042606
23	MP0000678_abnormal_parathyroid_gland	1.58285854
24	MP0003718_maternal_effect	1.56349852
25	MP0000631_abnormal_neuroendocrine_gland	1.55363643
26	MP0000372_irregular_coat_pigmentation	1.54435882
27	MP0002822_catalepsy	1.47795710
28	MP0001929_abnormal_gametogenesis	1.45491520
29	MP0003283_abnormal_digestive_organ	1.44065691
30	MP0003698_abnormal_male_reproductive	1.35910690
31	MP0001485_abnormal_pinna_reflex	1.28645140
32	MP0010678_abnormal_skin_adnexa	1.27243855
33	MP0001145_abnormal_male_reproductive	1.26795156
34	MP0002160_abnormal_reproductive_system	1.25384124
35	MP0000653_abnormal_sex_gland	1.23997573
36	MP0003693_abnormal_embryo_hatching	1.22891598
37	MP0002736_abnormal_nociception_after	1.17437841
38	MP0004233_abnormal_muscle_weight	1.17093246
39	MP0003121_genomic_imprinting	1.13997478
40	MP0009250_abnormal_appendicular_skeleto	1.12116635
41	MP0008058_abnormal_DNA_repair	1.03719559
42	MP0010030_abnormal_orbit_morphology	0.97237038
43	MP0005410_abnormal_fertilization	0.96986286
44	MP0002249_abnormal_larynx_morphology	0.96205655
45	MP0005187_abnormal_penis_morphology	0.96063784
46	MP0008995_early_reproductive_senescence	0.96026185
47	MP0003938_abnormal_ear_development	0.95630450
48	MP0003638_abnormal_response/metabolism_	0.88475371
49	MP0005377_hearing/vestibular/ear_phenot	0.84622238
50	MP0003878_abnormal_ear_physiology	0.84622238
51	MP0002282_abnormal_trachea_morphology	0.82914566
52	MP0005275_abnormal_skin_tensile	0.80654738
53	MP0004381_abnormal_hair_follicle	0.79651000
54	MP0003646_muscle_fatigue	0.79283036
55	MP0000647_abnormal_sebaceous_gland	0.78556339
56	MP0001968_abnormal_touch/_nociception	0.76006390
57	MP0001851_eye_inflammation	0.75713822
58	MP0005389_reproductive_system_phenotype	0.74146716
59	MP0001119_abnormal_female_reproductive	0.73525645
60	MP0000230_abnormal_systemic_arterial	0.71791696
61	MP0000049_abnormal_middle_ear	0.70093677
62	MP0006035_abnormal_mitochondrial_morpho	0.68624645
63	MP0005379_endocrine/exocrine_gland_phen	0.67403540
64	MP0002161_abnormal_fertility/fecundity	0.67393076
65	MP0008770_decreased_survivor_rate	0.64284285
66	MP0003699_abnormal_female_reproductive	0.61835075
67	MP0002089_abnormal_postnatal_growth/wei	0.59434149
68	MP0005451_abnormal_body_composition	0.58983002
69	MP0002653_abnormal_ependyma_morphology	0.57981728
70	MP0002229_neurodegeneration	0.54638890
71	MP0000681_abnormal_thyroid_gland	0.54461530
72	MP0001501_abnormal_sleep_pattern	0.54162769
73	MP0001963_abnormal_hearing_physiology	0.54146644
74	MP0001348_abnormal_lacrimal_gland	0.53687813
75	MP0002148_abnormal_hypersensitivity_rea	0.53579907
76	MP0001502_abnormal_circadian_rhythm	0.53250274
77	MP0003119_abnormal_digestive_system	0.52353474
78	MP0001664_abnormal_digestion	0.50879791
79	MP0002752_abnormal_somatic_nervous	0.50377194
80	MP0005386_behavior/neurological_phenoty	0.49524968
81	MP0004924_abnormal_behavior	0.49524968
82	MP0005310_abnormal_salivary_gland	0.47863027
83	MP0005551_abnormal_eye_electrophysiolog	0.46401834
84	MP0004742_abnormal_vestibular_system	0.45927677
85	MP0000490_abnormal_crypts_of	0.44551279
86	MP0001346_abnormal_lacrimal_gland	0.42924756
87	MP0002882_abnormal_neuron_morphology	0.42173471
88	MP0006036_abnormal_mitochondrial_physio	0.40534609
89	MP0003077_abnormal_cell_cycle	0.37645549
90	MP0002169_no_abnormal_phenotype	0.36969383
91	MP0002873_normal_phenotype	0.36770654
92	MP0003315_abnormal_perineum_morphology	0.35064518
93	MP0009745_abnormal_behavioral_response	0.34981448
94	MP0002067_abnormal_sensory_capabilities	0.34492158
95	MP0003937_abnormal_limbs/digits/tail_de	0.34455845
96	MP0004085_abnormal_heartbeat	0.33145114
97	MP0003786_premature_aging	0.32792113
98	MP0000579_abnormal_nail_morphology	0.32671526
99	MP0002063_abnormal_learning/memory/cond	0.31977907
100	MP0001730_embryonic_growth_arrest	0.31941245

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Keratoconjunctivitis sicca (HP:0001097)	9.36103583
2	Keratoconjunctivitis (HP:0001096)	8.69850169
3	Shoulder girdle muscle weakness (HP:0003547)	6.64502684
4	Rimmed vacuoles (HP:0003805)	5.81346528
5	11 pairs of ribs (HP:0000878)	5.43192573
6	Gonadotropin excess (HP:0000837)	4.69241826
7	Abnormality of the lower motor neuron (HP:0002366)	4.43027315
8	Keratitis (HP:0000491)	4.34666432
9	Oligodactyly (hands) (HP:0001180)	3.98942898
10	Tinnitus (HP:0000360)	3.84871187
11	Concave nail (HP:0001598)	3.82304269
12	Pigmentary retinal degeneration (HP:0001146)	3.75128603
13	Pili torti (HP:0003777)	3.64764176
14	Short chin (HP:0000331)	3.60606694
15	Severe visual impairment (HP:0001141)	3.28058216
16	Volvulus (HP:0002580)	3.27177892
17	Pelvic girdle muscle weakness (HP:0003749)	3.26476527
18	Premature skin wrinkling (HP:0100678)	3.26182823
19	Abnormal sex determination (HP:0012244)	3.10801531
20	Sex reversal (HP:0012245)	3.10801531
21	Brittle hair (HP:0002299)	3.05546728
22	Azoospermia (HP:0000027)	3.04502362
23	Amyotrophic lateral sclerosis (HP:0007354)	2.99762749
24	Congenital stationary night blindness (HP:0007642)	2.99628327
25	Hypoplastic iliac wings (HP:0002866)	2.96963317
26	Abnormality of cochlea (HP:0000375)	2.95456448
27	Limb-girdle muscle weakness (HP:0003325)	2.83180206
28	Relative macrocephaly (HP:0004482)	2.79884659
29	Abnormality of the hip-girdle musculature (HP:0001445)	2.76912634
30	Abnormality of the musculature of the pelvis (HP:0001469)	2.76912634
31	Oligodactyly (HP:0012165)	2.69155021
32	Horizontal nystagmus (HP:0000666)	2.68932353
33	Mesangial abnormality (HP:0001966)	2.64956273
34	Type II lissencephaly (HP:0007260)	2.62465795
35	True hermaphroditism (HP:0010459)	2.58034152
36	Metaphyseal cupping (HP:0003021)	2.57376904
37	Abnormality of the vitreous humor (HP:0004327)	2.57089146
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.53114081
39	Ventricular fibrillation (HP:0001663)	2.46502660
40	Retinal dysplasia (HP:0007973)	2.42498219
41	Missing ribs (HP:0000921)	2.42100412
42	Facial shape deformation (HP:0011334)	2.39751316
43	Potter facies (HP:0002009)	2.39751316
44	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.37495555
45	Increased nuchal translucency (HP:0010880)	2.37158952
46	Follicular hyperkeratosis (HP:0007502)	2.36237980
47	Upper motor neuron abnormality (HP:0002127)	2.36007785
48	Weak cry (HP:0001612)	2.35338872
49	Abnormality of the dental pulp (HP:0006479)	2.32647853
50	Abnormality of permanent molar morphology (HP:0011071)	2.31111892
51	Abnormality of the dental root (HP:0006486)	2.31111892
52	Taurodontia (HP:0000679)	2.31111892
53	Abnormal spermatogenesis (HP:0008669)	2.21641284
54	Thin ribs (HP:0000883)	2.20962423
55	Absent eyebrow (HP:0002223)	2.20378584
56	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.17887636
57	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.17887636
58	Sparse eyelashes (HP:0000653)	2.15368790
59	Abnormality of molar morphology (HP:0011070)	2.14928102
60	Abnormality of molar (HP:0011077)	2.14928102
61	Prominent supraorbital ridges (HP:0000336)	2.14122121
62	Hyperthyroidism (HP:0000836)	2.11272200
63	Increased connective tissue (HP:0009025)	2.10921241
64	Morphological abnormality of the inner ear (HP:0011390)	2.10584767
65	Cutis marmorata (HP:0000965)	2.05439673
66	Cerebellar dysplasia (HP:0007033)	2.03366734
67	Male pseudohermaphroditism (HP:0000037)	2.02010169
68	Delayed epiphyseal ossification (HP:0002663)	2.02008531
69	Spontaneous hematomas (HP:0007420)	2.00071245
70	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.98864926
71	Tubular atrophy (HP:0000092)	1.98181469
72	Hypoplastic nipples (HP:0002557)	1.97878040
73	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.94612556
74	Bulbar palsy (HP:0001283)	1.92164291
75	Congenital, generalized hypertrichosis (HP:0004540)	1.89930237
76	Hoarse voice (HP:0001609)	1.89241583
77	Intestinal polyposis (HP:0200008)	1.89234791
78	Anhidrosis (HP:0000970)	1.88892550
79	Muscle fiber atrophy (HP:0100295)	1.87541125
80	Irregular epiphyses (HP:0010582)	1.86296805
81	Type I diabetes mellitus (HP:0100651)	1.85947652
82	Congenital hip dislocation (HP:0001374)	1.85021369
83	Slow-growing hair (HP:0002217)	1.82237243
84	Abnormality of hair growth rate (HP:0011363)	1.82237243
85	Scotoma (HP:0000575)	1.81363249
86	Abnormal biliary tract physiology (HP:0012439)	1.81222663
87	Bile duct proliferation (HP:0001408)	1.81222663
88	Spinal muscular atrophy (HP:0007269)	1.80626985
89	Conical tooth (HP:0000698)	1.78155821
90	Intestinal polyp (HP:0005266)	1.74527556
91	Neoplasm of the colon (HP:0100273)	1.73012013
92	Dysphonia (HP:0001618)	1.72946288
93	Facial hemangioma (HP:0000329)	1.71322263
94	Cavernous hemangioma (HP:0001048)	1.71060230
95	Broad distal phalanx of finger (HP:0009836)	1.69230381
96	Abnormal urine output (HP:0012590)	1.65656045
97	Central scotoma (HP:0000603)	1.65484406
98	Bronchomalacia (HP:0002780)	1.65325297
99	Type 2 muscle fiber atrophy (HP:0003554)	1.63577533
100	Goiter (HP:0000853)	1.63516074

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TEC	8.40655966
2	ITK	6.26990308
3	PTK2	4.74262739
4	PNCK	4.71637152
5	BTK	3.75482416
6	BUB1	2.92544864
7	MKNK1	2.84835065
8	MAP3K10	2.49689018
9	MAPKAPK5	2.16559917
10	TRPM7	1.91818945
11	ERBB3	1.74133766
12	FRK	1.64072400
13	CDK19	1.52912432
14	KDR	1.49472352
15	CDK12	1.34233929
16	DYRK2	1.24343259
17	IRAK3	1.23540381
18	TRIB3	1.22794331
19	MET	1.09791587
20	CAMK1G	1.06743237
21	OXSR1	1.06156272
22	RIPK1	0.99710560
23	PINK1	0.98454263
24	CSF1R	0.97423684
25	STK38L	0.91714596
26	IGF1R	0.88870969
27	MAP2K7	0.87984603
28	PAK4	0.85087973
29	MAP2K1	0.84969338
30	TTK	0.84663623
31	STK38	0.83324501
32	PLK2	0.79087993
33	PDK2	0.77130312
34	ATR	0.76365652
35	PRKD3	0.75614656
36	NEK1	0.74216993
37	LATS2	0.72123660
38	ERBB2	0.70621454
39	KIT	0.69789898
40	FGR	0.68203556
41	DAPK1	0.67444080
42	MKNK2	0.67020446
43	BRSK1	0.65981515
44	UHMK1	0.63518446
45	BMX	0.62031509
46	MAP3K12	0.60754513
47	MST4	0.60518769
48	RPS6KB2	0.60141145
49	TESK2	0.57449454
50	MAP2K2	0.57241625
51	EPHA2	0.55265043
52	LIMK1	0.55154762
53	AKT3	0.54239391
54	STK16	0.53289331
55	ROCK1	0.52318245
56	SRPK1	0.50253772
57	RPS6KA5	0.49794720
58	DAPK2	0.46013356
59	PASK	0.43592625
60	INSR	0.43369553
61	PLK1	0.43307651
62	STK39	0.41067085
63	PDGFRA	0.38923944
64	AURKA	0.38217722
65	PTK2B	0.36200674
66	MAP2K6	0.36182752
67	CDK11A	0.34845309
68	CDK7	0.34173532
69	CSNK2A1	0.34034559
70	WNK4	0.33047255
71	ATM	0.32820363
72	ADRBK2	0.32070995
73	WEE1	0.32034178
74	PRKCI	0.31628662
75	VRK2	0.30116569
76	CDK5	0.30002435
77	ILK	0.29437356
78	PLK4	0.29133062
79	CDK3	0.28994896
80	NUAK1	0.28459455
81	NME2	0.26934903
82	CDK15	0.26719762
83	AKT2	0.26571846
84	MAP3K5	0.26206414
85	EGFR	0.25728190
86	RPS6KB1	0.24115340
87	CDK18	0.22530844
88	PRPF4B	0.21616627
89	CSNK1G3	0.20994788
90	CDK14	0.20650883
91	NEK2	0.20638372
92	SRC	0.19851905
93	CSNK2A2	0.18763201
94	TESK1	0.18545670
95	PAK1	0.18132176
96	CAMK2A	0.17126759
97	PRKACB	0.17088816
98	MAPKAPK3	0.15266058
99	GSK3B	0.14965100
100	PKN2	0.14935977

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taste transduction_Homo sapiens_hsa04742	7.86333939
2	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.68623121
3	Tryptophan metabolism_Homo sapiens_hsa00380	3.46489058
4	Sulfur relay system_Homo sapiens_hsa04122	3.01266141
5	Serotonergic synapse_Homo sapiens_hsa04726	2.36577969
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.16194178
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.03823128
8	Lysine degradation_Homo sapiens_hsa00310	1.92921056
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90676235
10	Proteasome_Homo sapiens_hsa03050	1.87915848
11	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.87663726
12	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.87562098
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76869388
14	Homologous recombination_Homo sapiens_hsa03440	1.73915537
15	DNA replication_Homo sapiens_hsa03030	1.66339784
16	Calcium signaling pathway_Homo sapiens_hsa04020	1.58306076
17	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.51479804
18	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.47517904
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.38419542
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.36902186
21	Olfactory transduction_Homo sapiens_hsa04740	1.34219150
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.24345560
23	Phototransduction_Homo sapiens_hsa04744	1.23348966
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.22785842
25	Base excision repair_Homo sapiens_hsa03410	1.20356953
26	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.19423179
27	Spliceosome_Homo sapiens_hsa03040	1.17392041
28	Mismatch repair_Homo sapiens_hsa03430	1.13324516
29	cAMP signaling pathway_Homo sapiens_hsa04024	1.13136136
30	Parkinsons disease_Homo sapiens_hsa05012	1.12074177
31	Choline metabolism in cancer_Homo sapiens_hsa05231	1.10259159
32	Cholinergic synapse_Homo sapiens_hsa04725	1.09066727
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.06345451
34	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.06229322
35	Renin secretion_Homo sapiens_hsa04924	1.03591219
36	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.03396773
37	Renin-angiotensin system_Homo sapiens_hsa04614	1.03391055
38	Oocyte meiosis_Homo sapiens_hsa04114	1.01222439
39	mRNA surveillance pathway_Homo sapiens_hsa03015	1.00767161
40	Circadian entrainment_Homo sapiens_hsa04713	0.96761076
41	Morphine addiction_Homo sapiens_hsa05032	0.96264651
42	Huntingtons disease_Homo sapiens_hsa05016	0.91311264
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.90188920
44	Cell cycle_Homo sapiens_hsa04110	0.88918324
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88717493
46	Nicotine addiction_Homo sapiens_hsa05033	0.86597450
47	Phenylalanine metabolism_Homo sapiens_hsa00360	0.85575301
48	RNA transport_Homo sapiens_hsa03013	0.84614914
49	Fatty acid degradation_Homo sapiens_hsa00071	0.81833319
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.80987122
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.78075595
52	Oxidative phosphorylation_Homo sapiens_hsa00190	0.77443643
53	Basal transcription factors_Homo sapiens_hsa03022	0.76073287
54	Carbon metabolism_Homo sapiens_hsa01200	0.74863568
55	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.74517672
56	Regulation of autophagy_Homo sapiens_hsa04140	0.72908821
57	VEGF signaling pathway_Homo sapiens_hsa04370	0.72248533
58	Alzheimers disease_Homo sapiens_hsa05010	0.71000010
59	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.70867872
60	Herpes simplex infection_Homo sapiens_hsa05168	0.69507720
61	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.68491001
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68214224
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.68211265
64	Long-term depression_Homo sapiens_hsa04730	0.66137580
65	One carbon pool by folate_Homo sapiens_hsa00670	0.64338044
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63401439
67	GABAergic synapse_Homo sapiens_hsa04727	0.61745006
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.61573565
69	Salivary secretion_Homo sapiens_hsa04970	0.58715943
70	Circadian rhythm_Homo sapiens_hsa04710	0.58522023
71	ABC transporters_Homo sapiens_hsa02010	0.56854697
72	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.53915305
73	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.53129678
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52110353
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51654165
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51276427
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.50222456
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.49529847
79	Purine metabolism_Homo sapiens_hsa00230	0.48597222
80	Alcoholism_Homo sapiens_hsa05034	0.45749511
81	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44564695
82	Notch signaling pathway_Homo sapiens_hsa04330	0.44549113
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.43344943
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42035847
85	ErbB signaling pathway_Homo sapiens_hsa04012	0.34824268
86	Small cell lung cancer_Homo sapiens_hsa05222	0.31146851
87	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.30958047
88	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.30121967
89	Axon guidance_Homo sapiens_hsa04360	0.28112974
90	Metabolic pathways_Homo sapiens_hsa01100	0.27773579
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.27668326
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.26278080
93	Caffeine metabolism_Homo sapiens_hsa00232	0.26169907
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.23959873
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.23304086
96	African trypanosomiasis_Homo sapiens_hsa05143	0.22266656
97	RNA degradation_Homo sapiens_hsa03018	0.22112846
98	mTOR signaling pathway_Homo sapiens_hsa04150	0.21170743
99	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.21062319
100	Endocytosis_Homo sapiens_hsa04144	0.20635944

DRD5P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »