DRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.27603566
2DNA deamination (GO:0045006)4.75877664
3proteasome assembly (GO:0043248)4.64790979
4nucleobase biosynthetic process (GO:0046112)4.50298613
5purine nucleobase biosynthetic process (GO:0009113)4.45301025
6DNA strand elongation involved in DNA replication (GO:0006271)4.38700914
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38479369
8ATP synthesis coupled proton transport (GO:0015986)4.38479369
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.37038821
10telomere maintenance via semi-conservative replication (GO:0032201)4.35958777
11cullin deneddylation (GO:0010388)4.34295802
12chaperone-mediated protein transport (GO:0072321)4.33766641
13maturation of SSU-rRNA (GO:0030490)4.24143127
14DNA strand elongation (GO:0022616)4.20436685
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.18201659
16formation of translation preinitiation complex (GO:0001731)4.16142943
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.14167277
18protein deneddylation (GO:0000338)4.13694063
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.11227113
20ribosome assembly (GO:0042255)3.99531088
21DNA replication initiation (GO:0006270)3.98460390
22ribosomal small subunit assembly (GO:0000028)3.98102957
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.97840614
24negative regulation of ligase activity (GO:0051352)3.97840614
25telomere maintenance via recombination (GO:0000722)3.91863121
26DNA replication checkpoint (GO:0000076)3.78021573
27ribosome biogenesis (GO:0042254)3.77815874
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.77699206
29termination of RNA polymerase III transcription (GO:0006386)3.77699206
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.77042433
31regulation of cellular amino acid metabolic process (GO:0006521)3.76572112
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75626039
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75626039
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75626039
357-methylguanosine mRNA capping (GO:0006370)3.75137252
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74094803
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71710191
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71710191
39RNA capping (GO:0036260)3.71039348
407-methylguanosine RNA capping (GO:0009452)3.71039348
41spliceosomal snRNP assembly (GO:0000387)3.70681007
42CENP-A containing nucleosome assembly (GO:0034080)3.68074316
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.67868674
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.67868674
45respiratory electron transport chain (GO:0022904)3.65457722
46ribosomal large subunit biogenesis (GO:0042273)3.64235191
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.63856476
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.63715022
49ribonucleoprotein complex biogenesis (GO:0022613)3.63004450
50mitotic recombination (GO:0006312)3.62594128
51rRNA modification (GO:0000154)3.60999527
52mitochondrial respiratory chain complex assembly (GO:0033108)3.59966324
53chromatin remodeling at centromere (GO:0031055)3.57800708
54protein complex biogenesis (GO:0070271)3.57174785
55electron transport chain (GO:0022900)3.55323922
56transcription-coupled nucleotide-excision repair (GO:0006283)3.52546371
57telomere maintenance via telomere lengthening (GO:0010833)3.49290619
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49175264
59establishment of viral latency (GO:0019043)3.47785069
60protein targeting to mitochondrion (GO:0006626)3.47566894
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.46818620
62positive regulation of ligase activity (GO:0051351)3.46690444
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.46238995
64NADH dehydrogenase complex assembly (GO:0010257)3.46238995
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.46238995
66respiratory chain complex IV assembly (GO:0008535)3.44061765
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.43980686
68mitotic metaphase plate congression (GO:0007080)3.42905362
69rRNA processing (GO:0006364)3.41373925
70DNA replication-dependent nucleosome organization (GO:0034723)3.38918555
71DNA replication-dependent nucleosome assembly (GO:0006335)3.38918555
72viral mRNA export from host cell nucleus (GO:0046784)3.34077708
73deoxyribonucleotide biosynthetic process (GO:0009263)3.34071329
74transcription elongation from RNA polymerase I promoter (GO:0006362)3.34057980
75ribosomal small subunit biogenesis (GO:0042274)3.33014116
76protein neddylation (GO:0045116)3.32651790
77pseudouridine synthesis (GO:0001522)3.31805330
78rRNA metabolic process (GO:0016072)3.31274650
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.30027472
80maturation of 5.8S rRNA (GO:0000460)3.28212891
81termination of RNA polymerase I transcription (GO:0006363)3.27650984
82cell cycle G1/S phase transition (GO:0044843)3.27633108
83G1/S transition of mitotic cell cycle (GO:0000082)3.27633108
84oxidative phosphorylation (GO:0006119)3.26266413
85attachment of spindle microtubules to kinetochore (GO:0008608)3.26124201
86DNA replication-independent nucleosome organization (GO:0034724)3.23533148
87DNA replication-independent nucleosome assembly (GO:0006336)3.23533148
88regulation of ubiquitin-protein transferase activity (GO:0051438)3.23261410
89establishment of integrated proviral latency (GO:0075713)3.21233593
90protein localization to mitochondrion (GO:0070585)3.20848424
91transcription from RNA polymerase I promoter (GO:0006360)3.20416241
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19796657
93establishment of protein localization to mitochondrion (GO:0072655)3.19152018
94IMP biosynthetic process (GO:0006188)3.19113582
95regulation of mitochondrial translation (GO:0070129)3.18816681
96mitochondrial RNA metabolic process (GO:0000959)3.15421681
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14158290
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14158290
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13954944
100protein localization to kinetochore (GO:0034501)3.10808742
101regulation of ligase activity (GO:0051340)3.10714769
102DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.08611654
103cellular component biogenesis (GO:0044085)3.08132259
104nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07882541
105cytochrome complex assembly (GO:0017004)3.07696570
106transcription from mitochondrial promoter (GO:0006390)3.06752413
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06239001
108translation (GO:0006412)3.05466236
109histone exchange (GO:0043486)3.05399121
110DNA ligation (GO:0006266)3.05353863
111DNA damage response, detection of DNA damage (GO:0042769)3.04468444
112viral transcription (GO:0019083)3.03184345
113cotranslational protein targeting to membrane (GO:0006613)3.03026036
114IMP metabolic process (GO:0046040)3.02385178
115DNA catabolic process, exonucleolytic (GO:0000738)3.02251228
116guanosine-containing compound biosynthetic process (GO:1901070)3.01256525
117positive regulation of cell cycle arrest (GO:0071158)3.01138752
118translational termination (GO:0006415)3.00669927
119tRNA methylation (GO:0030488)3.00579338
120rRNA methylation (GO:0031167)2.98784084
121spliceosomal complex assembly (GO:0000245)2.98413761
122protein targeting to ER (GO:0045047)2.96988744
123translational initiation (GO:0006413)2.96623800
124metaphase plate congression (GO:0051310)2.95455607
125tRNA aminoacylation for protein translation (GO:0006418)2.95069764
126transcription elongation from RNA polymerase II promoter (GO:0006368)2.94517142
127negative regulation of protein ubiquitination (GO:0031397)2.94263160
128regulation of helicase activity (GO:0051095)2.93092470
129transcription initiation from RNA polymerase I promoter (GO:0006361)2.91692687
130kinetochore assembly (GO:0051382)2.91473430
131establishment of protein localization to mitochondrial membrane (GO:0090151)2.91223667
132deoxyribose phosphate biosynthetic process (GO:0046385)2.90496626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.73441676
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.48816258
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.36496663
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.92598739
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.79340345
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.74924219
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52997816
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.45820900
9* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29617107
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17177413
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.17048454
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12618296
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09709332
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96026830
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92030676
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91080703
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69361027
18* VDR_23849224_ChIP-Seq_CD4+_Human2.67113293
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67020173
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64069255
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56862011
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47237318
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.43806093
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43662524
25XRN2_22483619_ChIP-Seq_HELA_Human2.43608550
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41710304
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27766083
28* DCP1A_22483619_ChIP-Seq_HELA_Human2.27481629
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27477091
30FOXP3_21729870_ChIP-Seq_TREG_Human2.23538561
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.21932219
32GABP_19822575_ChIP-Seq_HepG2_Human2.09323436
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03124238
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.03093570
35TTF2_22483619_ChIP-Seq_HELA_Human2.02759976
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99913359
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98902871
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97990325
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97680563
40ELK1_19687146_ChIP-ChIP_HELA_Human1.95738815
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90324095
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88626732
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86541577
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86300602
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77010847
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72625015
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66680126
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66048693
49AR_21909140_ChIP-Seq_LNCAP_Human1.64243364
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.52495568
51CIITA_25753668_ChIP-Seq_RAJI_Human1.48913796
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46903340
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46321916
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42980256
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42634678
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35878050
57KDM5A_27292631_Chip-Seq_BREAST_Human1.34753855
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34561130
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33676383
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29597640
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26254728
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23944558
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17450913
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15469809
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.14808255
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14399516
67MYC_18940864_ChIP-ChIP_HL60_Human1.13974177
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.13346974
69* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05723775
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04855617
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04477859
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.03927347
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03622312
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03551093
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01430671
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00525525
77TFEB_21752829_ChIP-Seq_HELA_Human0.99897635
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98848990
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94369373
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93296505
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92630807
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92530170
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90798634
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.89416431
85* EWS_26573619_Chip-Seq_HEK293_Human0.88182183
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87852031
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86926260
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86760632
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.85882396
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85569840
91ZNF274_21170338_ChIP-Seq_K562_Hela0.85480784
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84738416
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83744326
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83359357
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83188516
96* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82860626
97IRF1_19129219_ChIP-ChIP_H3396_Human0.82726431
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.82024365
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81588401
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80148748
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78217704
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76360601
103FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76215738
104SPI1_23547873_ChIP-Seq_NB4_Human0.76124190
105VDR_22108803_ChIP-Seq_LS180_Human0.75943748
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74142262
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.73659674
108FUS_26573619_Chip-Seq_HEK293_Human0.73403565
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71472784
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71367584
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70564803
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69824480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.04362535
2MP0004957_abnormal_blastocyst_morpholog4.60955751
3MP0010094_abnormal_chromosome_stability4.56332061
4MP0003111_abnormal_nucleus_morphology4.25908072
5MP0008058_abnormal_DNA_repair4.13312436
6MP0003077_abnormal_cell_cycle3.78562931
7MP0008057_abnormal_DNA_replication3.58522229
8MP0008932_abnormal_embryonic_tissue3.27111297
9MP0008007_abnormal_cellular_replicative3.00395853
10MP0008877_abnormal_DNA_methylation2.97272077
11MP0006292_abnormal_olfactory_placode2.85433074
12MP0003786_premature_aging2.67538942
13MP0003123_paternal_imprinting2.64880627
14MP0003718_maternal_effect2.57525940
15MP0008260_abnormal_autophagy2.01182110
16MP0001730_embryonic_growth_arrest1.79116502
17MP0000350_abnormal_cell_proliferation1.70652833
18MP0002102_abnormal_ear_morphology1.66296642
19MP0001188_hyperpigmentation1.62787244
20MP0003315_abnormal_perineum_morphology1.60131596
21MP0002160_abnormal_reproductive_system1.56615212
22MP0001529_abnormal_vocalization1.56413048
23MP0002396_abnormal_hematopoietic_system1.53089311
24MP0002210_abnormal_sex_determination1.50434982
25MP0003121_genomic_imprinting1.48624803
26MP0002837_dystrophic_cardiac_calcinosis1.43121369
27MP0003806_abnormal_nucleotide_metabolis1.40988848
28MP0005075_abnormal_melanosome_morpholog1.38059027
29MP0002234_abnormal_pharynx_morphology1.36544425
30MP0002938_white_spotting1.36488715
31MP0001145_abnormal_male_reproductive1.31461726
32MP0000313_abnormal_cell_death1.30172093
33MP0006035_abnormal_mitochondrial_morpho1.29841099
34MP0001986_abnormal_taste_sensitivity1.28744970
35MP0001697_abnormal_embryo_size1.27664651
36MP0008789_abnormal_olfactory_epithelium1.27014318
37MP0009379_abnormal_foot_pigmentation1.26829991
38MP0003186_abnormal_redox_activity1.26300803
39MP0005389_reproductive_system_phenotype1.26090940
40MP0000490_abnormal_crypts_of1.25869476
41MP0002080_prenatal_lethality1.25395882
42MP0000749_muscle_degeneration1.24148348
43MP0001929_abnormal_gametogenesis1.23385788
44MP0009333_abnormal_splenocyte_physiolog1.22201314
45MP0006036_abnormal_mitochondrial_physio1.19910080
46MP0002751_abnormal_autonomic_nervous1.15250994
47MP0003937_abnormal_limbs/digits/tail_de1.15044169
48MP0001672_abnormal_embryogenesis/_devel1.12780497
49MP0005380_embryogenesis_phenotype1.12780497
50MP0002019_abnormal_tumor_incidence1.09706223
51MP0002132_abnormal_respiratory_system1.09631020
52MP0000653_abnormal_sex_gland1.09311915
53MP0000358_abnormal_cell_content/1.09075556
54MP0002095_abnormal_skin_pigmentation1.09058730
55MP0003646_muscle_fatigue1.08836602
56MP0001293_anophthalmia1.06783805
57MP0004133_heterotaxia1.06669943
58MP0009697_abnormal_copulation1.06477948
59MP0010307_abnormal_tumor_latency1.03562847
60MP0002233_abnormal_nose_morphology1.03559016
61MP0000372_irregular_coat_pigmentation0.99768063
62MP0003890_abnormal_embryonic-extraembry0.99479864
63MP0002085_abnormal_embryonic_tissue0.98941328
64MP0001905_abnormal_dopamine_level0.93812202
65MP0005330_cardiomyopathy0.91655260
66MP0003984_embryonic_growth_retardation0.90951677
67MP0001764_abnormal_homeostasis0.90886060
68MP0005084_abnormal_gallbladder_morpholo0.90321825
69MP0000015_abnormal_ear_pigmentation0.89938158
70MP0003136_yellow_coat_color0.89472522
71MP0002090_abnormal_vision0.89423829
72MP0000647_abnormal_sebaceous_gland0.88633615
73MP0004808_abnormal_hematopoietic_stem0.88408282
74MP0001727_abnormal_embryo_implantation0.88122643
75MP0002088_abnormal_embryonic_growth/wei0.87970466
76MP0002084_abnormal_developmental_patter0.86570679
77MP0001919_abnormal_reproductive_system0.86455729
78MP0005408_hypopigmentation0.86335475
79MP0009672_abnormal_birth_weight0.85985817
80MP0002638_abnormal_pupillary_reflex0.85930686
81MP0005174_abnormal_tail_pigmentation0.84468500
82MP0003698_abnormal_male_reproductive0.84073800
83MP0001286_abnormal_eye_development0.82598972
84MP0003950_abnormal_plasma_membrane0.82244456
85MP0001346_abnormal_lacrimal_gland0.81993687
86MP0003011_delayed_dark_adaptation0.81107413
87MP0006072_abnormal_retinal_apoptosis0.80996527
88MP0004147_increased_porphyrin_level0.80859486
89MP0002736_abnormal_nociception_after0.80575296
90MP0005499_abnormal_olfactory_system0.78723883
91MP0005394_taste/olfaction_phenotype0.78723883
92MP0002653_abnormal_ependyma_morphology0.78677015
93MP0003221_abnormal_cardiomyocyte_apopto0.78244551
94MP0005266_abnormal_metabolism0.77874079
95MP0001119_abnormal_female_reproductive0.76587994
96MP0005397_hematopoietic_system_phenotyp0.76402934
97MP0001545_abnormal_hematopoietic_system0.76402934
98MP0001542_abnormal_bone_strength0.75871252
99MP0002111_abnormal_tail_morphology0.75476880
100MP0003938_abnormal_ear_development0.75118078
101MP0000703_abnormal_thymus_morphology0.74389525
102MP0004215_abnormal_myocardial_fiber0.74305281
103MP0003567_abnormal_fetal_cardiomyocyte0.72985322
104MP0008995_early_reproductive_senescence0.72682611
105MP0003119_abnormal_digestive_system0.72679953
106MP0005379_endocrine/exocrine_gland_phen0.69878351
107MP0002722_abnormal_immune_system0.69857297
108MP0002697_abnormal_eye_size0.69711656
109MP0001881_abnormal_mammary_gland0.69609994
110MP0005384_cellular_phenotype0.69308901
111MP0002398_abnormal_bone_marrow0.69230117
112MP0003941_abnormal_skin_development0.68970515
113MP0002163_abnormal_gland_morphology0.68904907
114MP0002277_abnormal_respiratory_mucosa0.68317679
115MP0001186_pigmentation_phenotype0.67655206
116MP0000689_abnormal_spleen_morphology0.66815968
117MP0002086_abnormal_extraembryonic_tissu0.66671692
118MP0000049_abnormal_middle_ear0.64981864
119MP0006276_abnormal_autonomic_nervous0.64903917
120MP0003755_abnormal_palate_morphology0.64427946
121MP0005671_abnormal_response_to0.63550486
122MP0000681_abnormal_thyroid_gland0.62469248
123MP0005253_abnormal_eye_physiology0.62382333
124MP0000762_abnormal_tongue_morphology0.62337121
125MP0004197_abnormal_fetal_growth/weight/0.61869251
126MP0002269_muscular_atrophy0.61355303
127MP0010030_abnormal_orbit_morphology0.60574351
128MP0002075_abnormal_coat/hair_pigmentati0.60339000
129MP0002876_abnormal_thyroid_physiology0.60076144
130MP0000516_abnormal_urinary_system0.59953188
131MP0005367_renal/urinary_system_phenotyp0.59953188
132MP0002429_abnormal_blood_cell0.59846998
133MP0009250_abnormal_appendicular_skeleto0.59628265
134MP0002161_abnormal_fertility/fecundity0.58543085
135MP0001661_extended_life_span0.58183964
136MP0003122_maternal_imprinting0.57876751

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.82991439
2Cerebral hypomyelination (HP:0006808)4.11573228
3Breast hypoplasia (HP:0003187)3.89532400
4Reticulocytopenia (HP:0001896)3.64374689
5Cerebral edema (HP:0002181)3.52790450
6Abnormality of cells of the erythroid lineage (HP:0012130)3.49266462
7Abnormal number of erythroid precursors (HP:0012131)3.42493092
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32542743
9Chromsome breakage (HP:0040012)3.29845811
10Renal Fanconi syndrome (HP:0001994)3.29732732
11Rough bone trabeculation (HP:0100670)3.21101863
12Carpal bone hypoplasia (HP:0001498)3.16648251
13Increased intramyocellular lipid droplets (HP:0012240)3.15376877
14Abnormality of the anterior horn cell (HP:0006802)3.09155012
15Degeneration of anterior horn cells (HP:0002398)3.09155012
16Abnormality of the preputium (HP:0100587)3.05820763
17Oral leukoplakia (HP:0002745)3.05084625
18Type I transferrin isoform profile (HP:0003642)3.04066098
19Aplastic anemia (HP:0001915)2.98630146
20Meckel diverticulum (HP:0002245)2.94536824
21Acute necrotizing encephalopathy (HP:0006965)2.94273076
223-Methylglutaconic aciduria (HP:0003535)2.89118224
23Mitochondrial inheritance (HP:0001427)2.86207025
24Abnormality of the ileum (HP:0001549)2.82844023
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.78509404
26Abnormality of chromosome stability (HP:0003220)2.77177968
27Increased serum lactate (HP:0002151)2.76991531
28Increased CSF lactate (HP:0002490)2.76847070
2911 pairs of ribs (HP:0000878)2.74436357
30Hepatocellular necrosis (HP:0001404)2.73979570
31Macrocytic anemia (HP:0001972)2.72509211
32Respiratory failure (HP:0002878)2.72491860
33Abnormality of glycolysis (HP:0004366)2.71135255
34Increased serum pyruvate (HP:0003542)2.71135255
35Respiratory difficulties (HP:0002880)2.70456268
36Abnormal mitochondria in muscle tissue (HP:0008316)2.66567931
37Patellar aplasia (HP:0006443)2.62282461
38Bone marrow hypocellularity (HP:0005528)2.61225975
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61167602
40Abnormality of alanine metabolism (HP:0010916)2.61167602
41Hyperalaninemia (HP:0003348)2.61167602
42Increased muscle lipid content (HP:0009058)2.59908918
43Microvesicular hepatic steatosis (HP:0001414)2.59541213
44Premature graying of hair (HP:0002216)2.58813669
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53165925
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53165925
47Microretrognathia (HP:0000308)2.52777929
48Aplasia/Hypoplasia of the patella (HP:0006498)2.51183372
49CNS hypomyelination (HP:0003429)2.48987763
50Leukodystrophy (HP:0002415)2.48756639
51Increased hepatocellular lipid droplets (HP:0006565)2.46929476
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45974044
53Abnormality of the labia minora (HP:0012880)2.41676030
54Abnormal trabecular bone morphology (HP:0100671)2.41416014
55Absent radius (HP:0003974)2.40830264
56Hepatic necrosis (HP:0002605)2.39911657
57Pallor (HP:0000980)2.39198315
58Absent thumb (HP:0009777)2.38071252
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35687686
60Duodenal stenosis (HP:0100867)2.34924090
61Small intestinal stenosis (HP:0012848)2.34924090
62Agnosia (HP:0010524)2.33705986
63Exertional dyspnea (HP:0002875)2.30578190
64Long foot (HP:0001833)2.30241293
65Megaloblastic anemia (HP:0001889)2.27186635
66Impulsivity (HP:0100710)2.26582877
67Abnormality of methionine metabolism (HP:0010901)2.24922778
68Multiple enchondromatosis (HP:0005701)2.24729394
69Abnormality of placental membranes (HP:0011409)2.24592838
70Amniotic constriction ring (HP:0009775)2.24592838
71Absent forearm bone (HP:0003953)2.23435542
72Aplasia involving forearm bones (HP:0009822)2.23435542
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22415664
74Pancreatic fibrosis (HP:0100732)2.21353894
75Nephroblastoma (Wilms tumor) (HP:0002667)2.21303250
76Colon cancer (HP:0003003)2.21255507
77Pancytopenia (HP:0001876)2.20441546
78Methylmalonic acidemia (HP:0002912)2.19718479
79Duplicated collecting system (HP:0000081)2.19473067
80CNS demyelination (HP:0007305)2.18139702
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17368287
82Progressive macrocephaly (HP:0004481)2.17217099
83Horseshoe kidney (HP:0000085)2.17131238
84Postnatal microcephaly (HP:0005484)2.16976277
85Secondary amenorrhea (HP:0000869)2.16078743
86Abnormality of serum amino acid levels (HP:0003112)2.15317963
87Lethargy (HP:0001254)2.14223475
88Pancreatic cysts (HP:0001737)2.14110040
89Reduced antithrombin III activity (HP:0001976)2.13428542
90Selective tooth agenesis (HP:0001592)2.12561752
91Myelodysplasia (HP:0002863)2.12522406
92Methylmalonic aciduria (HP:0012120)2.12201192
93Embryonal renal neoplasm (HP:0011794)2.11875942
94Supernumerary spleens (HP:0009799)2.10771376
95Acute encephalopathy (HP:0006846)2.09978200
96Neoplasm of the pancreas (HP:0002894)2.08350637
97Hyperglycinemia (HP:0002154)2.06772730
98Abnormal lung lobation (HP:0002101)2.06759031
99Medulloblastoma (HP:0002885)2.05285276
100Optic disc pallor (HP:0000543)2.04449121
101Facial cleft (HP:0002006)2.03559561
102Sloping forehead (HP:0000340)2.02304678
103Cellular immunodeficiency (HP:0005374)2.02235668
104Abnormal spermatogenesis (HP:0008669)2.01792428
105Lipid accumulation in hepatocytes (HP:0006561)2.01428462
106Triphalangeal thumb (HP:0001199)2.00269568
107Progressive muscle weakness (HP:0003323)1.99099330
108Hypoplasia of the pons (HP:0012110)1.98928991
109Lactic acidosis (HP:0003128)1.98869966
110Type 2 muscle fiber atrophy (HP:0003554)1.98608053
111Exercise intolerance (HP:0003546)1.98272378
112Abnormality of the renal collecting system (HP:0004742)1.98098387
113Abnormal glycosylation (HP:0012345)1.97023850
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97023850
115Abnormal protein N-linked glycosylation (HP:0012347)1.97023850
116Abnormal protein glycosylation (HP:0012346)1.97023850
117Abnormality of the duodenum (HP:0002246)1.96529954
118Premature ovarian failure (HP:0008209)1.95295345
119Ependymoma (HP:0002888)1.95103277
120Poor head control (HP:0002421)1.93100219
121Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92598058
122Neoplasm of the adrenal cortex (HP:0100641)1.92090532
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91725236
124X-linked dominant inheritance (HP:0001423)1.88048841
125Emotional lability (HP:0000712)1.83335385
126Abnormality of renal resorption (HP:0011038)1.82618752
127Sparse eyelashes (HP:0000653)1.82425304
128Neoplasm of the colon (HP:0100273)1.77987523
129Dicarboxylic aciduria (HP:0003215)1.71494962
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71494962
131Aplasia/hypoplasia of the uterus (HP:0008684)1.70422052
132Abnormalities of placenta or umbilical cord (HP:0001194)1.69850781
133Neoplasm of the adrenal gland (HP:0100631)1.68444140
134Abnormality of the umbilical cord (HP:0010881)1.64513717
135Spastic diplegia (HP:0001264)1.63466703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.80955885
2VRK24.44859811
3WEE14.27916318
4EIF2AK13.18563911
5TSSK63.10423582
6SRPK12.57766297
7* STK162.56770453
8PLK42.55819574
9VRK12.54283844
10CDC72.53094017
11EIF2AK32.45984426
12TRIM282.34674804
13BRSK22.23938927
14ACVR1B2.21587213
15NEK12.06607533
16MKNK12.06488057
17ZAK2.02243217
18NUAK11.96592159
19MKNK21.90807746
20CCNB11.89131326
21PLK31.80497918
22TTK1.72049515
23PLK11.71053816
24NEK21.58573171
25TLK11.56070251
26NME21.51133313
27EPHA21.50353648
28NME11.50278434
29TAF11.47784978
30BRAF1.45309408
31BRSK11.44780988
32DYRK31.44264718
33PASK1.37840330
34MAP3K121.36935888
35PIM21.30379793
36ATR1.29939795
37TESK21.29543055
38AKT31.27372474
39AURKB1.18899680
40MAP4K21.15671445
41CASK1.15187687
42AURKA1.12929446
43PNCK1.12758932
44CDK71.12522589
45CHEK21.11449702
46ARAF1.09007068
47EIF2AK21.08673048
48CDK81.07125197
49MST41.06299782
50RPS6KB21.03936691
51IRAK30.98553851
52CSNK1G10.83537409
53DAPK10.79630985
54CDK190.79167428
55PRKCI0.79004249
56TGFBR10.78548257
57DYRK20.78211721
58CHEK10.74390075
59IRAK40.72738467
60PAK40.72564928
61CSNK2A10.71232590
62CSNK1A1L0.70806636
63TESK10.70210559
64ADRBK20.70076188
65CSNK1G20.67296207
66CSNK2A20.66563429
67PDK40.66557639
68PDK30.66557639
69BMPR1B0.65345402
70ABL20.64879175
71LIMK10.61688720
72BCR0.61032755
73OBSCN0.60346972
74KDR0.60306354
75PBK0.59282826
76MAP3K80.57596362
77SIK30.54798656
78PAK10.54773880
79BLK0.52427746
80RPS6KA40.51475670
81RPS6KA50.50823960
82BCKDK0.50643654
83CDK40.50542694
84PHKG10.50236489
85PHKG20.50236489
86ATM0.47996060
87ERBB40.47271096
88PDK20.46913882
89MYLK0.44865572
90CDK20.44440774
91CSNK1G30.44063999
92MAP2K70.43972790
93YES10.42611400
94CAMK2B0.41787686
95MINK10.40081623
96DAPK30.39981299
97MAPKAPK50.39392511
98CDK10.38116278
99TXK0.36814660
100OXSR10.36254967
101PLK20.35754078
102MARK10.35375729
103CAMKK20.34907965
104WNK30.34386617
105BRD40.33868089
106ALK0.33198259
107STK40.33127255
108CDK90.32827843
109TEC0.31892343
110CLK10.31727360
111AKT20.31117686
112PIM10.30741154
113STK38L0.30147532
114TNIK0.29735936
115GRK10.28690446
116MUSK0.28684457
117ERBB30.27451511
118INSRR0.27184761
119CDK30.26977333
120CSNK1A10.26915480
121STK240.25812033
122NEK60.23256219
123SCYL20.22762785
124PRKG20.19891141
125CSNK1E0.19755084
126ILK0.19700966
127CAMK2G0.18084745

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.93969075
2DNA replication_Homo sapiens_hsa030304.46706919
3Mismatch repair_Homo sapiens_hsa034303.93517975
4RNA polymerase_Homo sapiens_hsa030203.80979364
5Ribosome_Homo sapiens_hsa030103.59190236
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55353644
7Spliceosome_Homo sapiens_hsa030403.05250226
8Nucleotide excision repair_Homo sapiens_hsa034202.87313863
9Pyrimidine metabolism_Homo sapiens_hsa002402.80995517
10Homologous recombination_Homo sapiens_hsa034402.79633539
11RNA transport_Homo sapiens_hsa030132.76325402
12Base excision repair_Homo sapiens_hsa034102.73379123
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56651617
14Fanconi anemia pathway_Homo sapiens_hsa034602.19983908
15Cell cycle_Homo sapiens_hsa041102.19971730
16Basal transcription factors_Homo sapiens_hsa030222.17365501
17Protein export_Homo sapiens_hsa030601.93013464
18Oxidative phosphorylation_Homo sapiens_hsa001901.82930628
19One carbon pool by folate_Homo sapiens_hsa006701.82305609
20Non-homologous end-joining_Homo sapiens_hsa034501.80913850
21RNA degradation_Homo sapiens_hsa030181.72614164
22Purine metabolism_Homo sapiens_hsa002301.72431399
23Parkinsons disease_Homo sapiens_hsa050121.67307593
24Fatty acid elongation_Homo sapiens_hsa000621.59374139
25Huntingtons disease_Homo sapiens_hsa050161.50253965
26Propanoate metabolism_Homo sapiens_hsa006401.48481300
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38913609
28Vitamin B6 metabolism_Homo sapiens_hsa007501.35473507
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27662199
30p53 signaling pathway_Homo sapiens_hsa041151.20087716
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19173376
32Epstein-Barr virus infection_Homo sapiens_hsa051691.18995964
33mRNA surveillance pathway_Homo sapiens_hsa030151.18298490
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12298831
35Cardiac muscle contraction_Homo sapiens_hsa042601.11920690
36Folate biosynthesis_Homo sapiens_hsa007901.02426246
37Steroid biosynthesis_Homo sapiens_hsa001000.97834398
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93195934
39Regulation of autophagy_Homo sapiens_hsa041400.91244257
40Alzheimers disease_Homo sapiens_hsa050100.90240441
41Sulfur metabolism_Homo sapiens_hsa009200.88938692
42Pentose phosphate pathway_Homo sapiens_hsa000300.88650148
43Systemic lupus erythematosus_Homo sapiens_hsa053220.88395061
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.86229081
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84763834
46Oocyte meiosis_Homo sapiens_hsa041140.83099002
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.73817070
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73798700
49Antigen processing and presentation_Homo sapiens_hsa046120.68927307
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68735048
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67738092
52Selenocompound metabolism_Homo sapiens_hsa004500.67216573
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66606678
54Collecting duct acid secretion_Homo sapiens_hsa049660.66081613
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65288470
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64210475
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62301612
58Biosynthesis of amino acids_Homo sapiens_hsa012300.62194474
59Viral carcinogenesis_Homo sapiens_hsa052030.59627832
60Glutathione metabolism_Homo sapiens_hsa004800.58556915
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57596207
62Peroxisome_Homo sapiens_hsa041460.57115160
63Fatty acid metabolism_Homo sapiens_hsa012120.56914212
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.56113562
65Fructose and mannose metabolism_Homo sapiens_hsa000510.55175160
66Butanoate metabolism_Homo sapiens_hsa006500.53486885
67Metabolic pathways_Homo sapiens_hsa011000.52431206
68Fatty acid degradation_Homo sapiens_hsa000710.51917213
69N-Glycan biosynthesis_Homo sapiens_hsa005100.51853173
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51607946
71Vibrio cholerae infection_Homo sapiens_hsa051100.51446637
72Herpes simplex infection_Homo sapiens_hsa051680.50546159
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49071944
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48252664
75Carbon metabolism_Homo sapiens_hsa012000.44727650
76Alcoholism_Homo sapiens_hsa050340.42967666
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41830856
78Tryptophan metabolism_Homo sapiens_hsa003800.40710206
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40647861
80Legionellosis_Homo sapiens_hsa051340.39168410
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38123871
82Arachidonic acid metabolism_Homo sapiens_hsa005900.37030187
83Primary immunodeficiency_Homo sapiens_hsa053400.34324203
84beta-Alanine metabolism_Homo sapiens_hsa004100.34154981
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32354579
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31769000
87Sulfur relay system_Homo sapiens_hsa041220.29235566
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28508811
89HTLV-I infection_Homo sapiens_hsa051660.26469635
90Autoimmune thyroid disease_Homo sapiens_hsa053200.25024221
91Renin-angiotensin system_Homo sapiens_hsa046140.24032689
92Asthma_Homo sapiens_hsa053100.23664083
93Type I diabetes mellitus_Homo sapiens_hsa049400.22393691
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22285590
95Allograft rejection_Homo sapiens_hsa053300.21178338
96Phototransduction_Homo sapiens_hsa047440.19331914
97Linoleic acid metabolism_Homo sapiens_hsa005910.18521558
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.18418472
99Galactose metabolism_Homo sapiens_hsa000520.18324421
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18267547
101Phagosome_Homo sapiens_hsa041450.18250959
102Pyruvate metabolism_Homo sapiens_hsa006200.17293768
103TGF-beta signaling pathway_Homo sapiens_hsa043500.17174257
104Tyrosine metabolism_Homo sapiens_hsa003500.16803183
105Other glycan degradation_Homo sapiens_hsa005110.16197951
106Arginine and proline metabolism_Homo sapiens_hsa003300.15982355
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13363539
108Rheumatoid arthritis_Homo sapiens_hsa053230.13062479
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11824424
110Thyroid cancer_Homo sapiens_hsa052160.11042972
111Measles_Homo sapiens_hsa051620.10717211
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.10456524
113Shigellosis_Homo sapiens_hsa051310.07108293
114Nitrogen metabolism_Homo sapiens_hsa009100.06726499
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.06726027
116Basal cell carcinoma_Homo sapiens_hsa052170.06603275
117Apoptosis_Homo sapiens_hsa042100.06536779
118Hedgehog signaling pathway_Homo sapiens_hsa043400.04305207
119Lysine degradation_Homo sapiens_hsa003100.04177947
120Vitamin digestion and absorption_Homo sapiens_hsa049770.04110274
121Chemical carcinogenesis_Homo sapiens_hsa052040.04049978
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.03869201
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.03756176
124Wnt signaling pathway_Homo sapiens_hsa043100.03626204
125Retinol metabolism_Homo sapiens_hsa008300.02745602
126Phenylalanine metabolism_Homo sapiens_hsa003600.02736573
127Graft-versus-host disease_Homo sapiens_hsa053320.02720787
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.01667771
129Ether lipid metabolism_Homo sapiens_hsa005650.00384591
130Hematopoietic cell lineage_Homo sapiens_hsa046400.00112970

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