

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.27603566 |
| 2 | DNA deamination (GO:0045006) | 4.75877664 |
| 3 | proteasome assembly (GO:0043248) | 4.64790979 |
| 4 | nucleobase biosynthetic process (GO:0046112) | 4.50298613 |
| 5 | purine nucleobase biosynthetic process (GO:0009113) | 4.45301025 |
| 6 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.38700914 |
| 7 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.38479369 |
| 8 | ATP synthesis coupled proton transport (GO:0015986) | 4.38479369 |
| 9 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.37038821 |
| 10 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.35958777 |
| 11 | cullin deneddylation (GO:0010388) | 4.34295802 |
| 12 | chaperone-mediated protein transport (GO:0072321) | 4.33766641 |
| 13 | maturation of SSU-rRNA (GO:0030490) | 4.24143127 |
| 14 | DNA strand elongation (GO:0022616) | 4.20436685 |
| 15 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.18201659 |
| 16 | formation of translation preinitiation complex (GO:0001731) | 4.16142943 |
| 17 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.14167277 |
| 18 | protein deneddylation (GO:0000338) | 4.13694063 |
| 19 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.11227113 |
| 20 | ribosome assembly (GO:0042255) | 3.99531088 |
| 21 | DNA replication initiation (GO:0006270) | 3.98460390 |
| 22 | ribosomal small subunit assembly (GO:0000028) | 3.98102957 |
| 23 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.97840614 |
| 24 | negative regulation of ligase activity (GO:0051352) | 3.97840614 |
| 25 | telomere maintenance via recombination (GO:0000722) | 3.91863121 |
| 26 | DNA replication checkpoint (GO:0000076) | 3.78021573 |
| 27 | ribosome biogenesis (GO:0042254) | 3.77815874 |
| 28 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.77699206 |
| 29 | termination of RNA polymerase III transcription (GO:0006386) | 3.77699206 |
| 30 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.77042433 |
| 31 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.76572112 |
| 32 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.75626039 |
| 33 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.75626039 |
| 34 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.75626039 |
| 35 | 7-methylguanosine mRNA capping (GO:0006370) | 3.75137252 |
| 36 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.74094803 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.71710191 |
| 38 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.71710191 |
| 39 | RNA capping (GO:0036260) | 3.71039348 |
| 40 | 7-methylguanosine RNA capping (GO:0009452) | 3.71039348 |
| 41 | spliceosomal snRNP assembly (GO:0000387) | 3.70681007 |
| 42 | CENP-A containing nucleosome assembly (GO:0034080) | 3.68074316 |
| 43 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.67868674 |
| 44 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.67868674 |
| 45 | respiratory electron transport chain (GO:0022904) | 3.65457722 |
| 46 | ribosomal large subunit biogenesis (GO:0042273) | 3.64235191 |
| 47 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.63856476 |
| 48 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.63715022 |
| 49 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.63004450 |
| 50 | mitotic recombination (GO:0006312) | 3.62594128 |
| 51 | rRNA modification (GO:0000154) | 3.60999527 |
| 52 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.59966324 |
| 53 | chromatin remodeling at centromere (GO:0031055) | 3.57800708 |
| 54 | protein complex biogenesis (GO:0070271) | 3.57174785 |
| 55 | electron transport chain (GO:0022900) | 3.55323922 |
| 56 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.52546371 |
| 57 | telomere maintenance via telomere lengthening (GO:0010833) | 3.49290619 |
| 58 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.49175264 |
| 59 | establishment of viral latency (GO:0019043) | 3.47785069 |
| 60 | protein targeting to mitochondrion (GO:0006626) | 3.47566894 |
| 61 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.46818620 |
| 62 | positive regulation of ligase activity (GO:0051351) | 3.46690444 |
| 63 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.46238995 |
| 64 | NADH dehydrogenase complex assembly (GO:0010257) | 3.46238995 |
| 65 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.46238995 |
| 66 | respiratory chain complex IV assembly (GO:0008535) | 3.44061765 |
| 67 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.43980686 |
| 68 | mitotic metaphase plate congression (GO:0007080) | 3.42905362 |
| 69 | rRNA processing (GO:0006364) | 3.41373925 |
| 70 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.38918555 |
| 71 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.38918555 |
| 72 | viral mRNA export from host cell nucleus (GO:0046784) | 3.34077708 |
| 73 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.34071329 |
| 74 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.34057980 |
| 75 | ribosomal small subunit biogenesis (GO:0042274) | 3.33014116 |
| 76 | protein neddylation (GO:0045116) | 3.32651790 |
| 77 | pseudouridine synthesis (GO:0001522) | 3.31805330 |
| 78 | rRNA metabolic process (GO:0016072) | 3.31274650 |
| 79 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.30027472 |
| 80 | maturation of 5.8S rRNA (GO:0000460) | 3.28212891 |
| 81 | termination of RNA polymerase I transcription (GO:0006363) | 3.27650984 |
| 82 | cell cycle G1/S phase transition (GO:0044843) | 3.27633108 |
| 83 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.27633108 |
| 84 | oxidative phosphorylation (GO:0006119) | 3.26266413 |
| 85 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.26124201 |
| 86 | DNA replication-independent nucleosome organization (GO:0034724) | 3.23533148 |
| 87 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.23533148 |
| 88 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.23261410 |
| 89 | establishment of integrated proviral latency (GO:0075713) | 3.21233593 |
| 90 | protein localization to mitochondrion (GO:0070585) | 3.20848424 |
| 91 | transcription from RNA polymerase I promoter (GO:0006360) | 3.20416241 |
| 92 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.19796657 |
| 93 | establishment of protein localization to mitochondrion (GO:0072655) | 3.19152018 |
| 94 | IMP biosynthetic process (GO:0006188) | 3.19113582 |
| 95 | regulation of mitochondrial translation (GO:0070129) | 3.18816681 |
| 96 | mitochondrial RNA metabolic process (GO:0000959) | 3.15421681 |
| 97 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.14158290 |
| 98 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.14158290 |
| 99 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.13954944 |
| 100 | protein localization to kinetochore (GO:0034501) | 3.10808742 |
| 101 | regulation of ligase activity (GO:0051340) | 3.10714769 |
| 102 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.08611654 |
| 103 | cellular component biogenesis (GO:0044085) | 3.08132259 |
| 104 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.07882541 |
| 105 | cytochrome complex assembly (GO:0017004) | 3.07696570 |
| 106 | transcription from mitochondrial promoter (GO:0006390) | 3.06752413 |
| 107 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.06239001 |
| 108 | translation (GO:0006412) | 3.05466236 |
| 109 | histone exchange (GO:0043486) | 3.05399121 |
| 110 | DNA ligation (GO:0006266) | 3.05353863 |
| 111 | DNA damage response, detection of DNA damage (GO:0042769) | 3.04468444 |
| 112 | viral transcription (GO:0019083) | 3.03184345 |
| 113 | cotranslational protein targeting to membrane (GO:0006613) | 3.03026036 |
| 114 | IMP metabolic process (GO:0046040) | 3.02385178 |
| 115 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.02251228 |
| 116 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.01256525 |
| 117 | positive regulation of cell cycle arrest (GO:0071158) | 3.01138752 |
| 118 | translational termination (GO:0006415) | 3.00669927 |
| 119 | tRNA methylation (GO:0030488) | 3.00579338 |
| 120 | rRNA methylation (GO:0031167) | 2.98784084 |
| 121 | spliceosomal complex assembly (GO:0000245) | 2.98413761 |
| 122 | protein targeting to ER (GO:0045047) | 2.96988744 |
| 123 | translational initiation (GO:0006413) | 2.96623800 |
| 124 | metaphase plate congression (GO:0051310) | 2.95455607 |
| 125 | tRNA aminoacylation for protein translation (GO:0006418) | 2.95069764 |
| 126 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 2.94517142 |
| 127 | negative regulation of protein ubiquitination (GO:0031397) | 2.94263160 |
| 128 | regulation of helicase activity (GO:0051095) | 2.93092470 |
| 129 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.91692687 |
| 130 | kinetochore assembly (GO:0051382) | 2.91473430 |
| 131 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.91223667 |
| 132 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.90496626 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.73441676 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.48816258 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.36496663 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.92598739 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.79340345 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.74924219 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.52997816 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.45820900 |
| 9 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.29617107 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.17177413 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.17048454 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.12618296 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.09709332 |
| 14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.96026830 |
| 15 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.92030676 |
| 16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.91080703 |
| 17 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.69361027 |
| 18 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.67113293 |
| 19 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.67020173 |
| 20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.64069255 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.56862011 |
| 22 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.47237318 |
| 23 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.43806093 |
| 24 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.43662524 |
| 25 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.43608550 |
| 26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.41710304 |
| 27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.27766083 |
| 28 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.27481629 |
| 29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.27477091 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.23538561 |
| 31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.21932219 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.09323436 |
| 33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.03124238 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.03093570 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.02759976 |
| 36 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.99913359 |
| 37 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.98902871 |
| 38 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.97990325 |
| 39 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.97680563 |
| 40 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.95738815 |
| 41 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.90324095 |
| 42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.88626732 |
| 43 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.86541577 |
| 44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.86300602 |
| 45 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.77010847 |
| 46 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.72625015 |
| 47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.66680126 |
| 48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.66048693 |
| 49 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.64243364 |
| 50 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.52495568 |
| 51 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.48913796 |
| 52 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.46903340 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.46321916 |
| 54 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.42980256 |
| 55 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42634678 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.35878050 |
| 57 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.34753855 |
| 58 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.34561130 |
| 59 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.33676383 |
| 60 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.29597640 |
| 61 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26254728 |
| 62 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.23944558 |
| 63 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.17450913 |
| 64 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.15469809 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.14808255 |
| 66 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.14399516 |
| 67 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.13974177 |
| 68 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.13346974 |
| 69 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.05723775 |
| 70 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.04855617 |
| 71 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.04477859 |
| 72 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.03927347 |
| 73 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.03622312 |
| 74 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03551093 |
| 75 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.01430671 |
| 76 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.00525525 |
| 77 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.99897635 |
| 78 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.98848990 |
| 79 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.94369373 |
| 80 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.93296505 |
| 81 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.92630807 |
| 82 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.92530170 |
| 83 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.90798634 |
| 84 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89416431 |
| 85 | * EWS_26573619_Chip-Seq_HEK293_Human | 0.88182183 |
| 86 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.87852031 |
| 87 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.86926260 |
| 88 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.86760632 |
| 89 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.85882396 |
| 90 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.85569840 |
| 91 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.85480784 |
| 92 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.84738416 |
| 93 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.83744326 |
| 94 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83359357 |
| 95 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.83188516 |
| 96 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.82860626 |
| 97 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.82726431 |
| 98 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.82024365 |
| 99 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.81588401 |
| 100 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.80148748 |
| 101 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78217704 |
| 102 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.76360601 |
| 103 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.76215738 |
| 104 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.76124190 |
| 105 | VDR_22108803_ChIP-Seq_LS180_Human | 0.75943748 |
| 106 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.74142262 |
| 107 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.73659674 |
| 108 | FUS_26573619_Chip-Seq_HEK293_Human | 0.73403565 |
| 109 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.71472784 |
| 110 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.71367584 |
| 111 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.70564803 |
| 112 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.69824480 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.04362535 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.60955751 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.56332061 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.25908072 |
| 5 | MP0008058_abnormal_DNA_repair | 4.13312436 |
| 6 | MP0003077_abnormal_cell_cycle | 3.78562931 |
| 7 | MP0008057_abnormal_DNA_replication | 3.58522229 |
| 8 | MP0008932_abnormal_embryonic_tissue | 3.27111297 |
| 9 | MP0008007_abnormal_cellular_replicative | 3.00395853 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.97272077 |
| 11 | MP0006292_abnormal_olfactory_placode | 2.85433074 |
| 12 | MP0003786_premature_aging | 2.67538942 |
| 13 | MP0003123_paternal_imprinting | 2.64880627 |
| 14 | MP0003718_maternal_effect | 2.57525940 |
| 15 | MP0008260_abnormal_autophagy | 2.01182110 |
| 16 | MP0001730_embryonic_growth_arrest | 1.79116502 |
| 17 | MP0000350_abnormal_cell_proliferation | 1.70652833 |
| 18 | MP0002102_abnormal_ear_morphology | 1.66296642 |
| 19 | MP0001188_hyperpigmentation | 1.62787244 |
| 20 | MP0003315_abnormal_perineum_morphology | 1.60131596 |
| 21 | MP0002160_abnormal_reproductive_system | 1.56615212 |
| 22 | MP0001529_abnormal_vocalization | 1.56413048 |
| 23 | MP0002396_abnormal_hematopoietic_system | 1.53089311 |
| 24 | MP0002210_abnormal_sex_determination | 1.50434982 |
| 25 | MP0003121_genomic_imprinting | 1.48624803 |
| 26 | MP0002837_dystrophic_cardiac_calcinosis | 1.43121369 |
| 27 | MP0003806_abnormal_nucleotide_metabolis | 1.40988848 |
| 28 | MP0005075_abnormal_melanosome_morpholog | 1.38059027 |
| 29 | MP0002234_abnormal_pharynx_morphology | 1.36544425 |
| 30 | MP0002938_white_spotting | 1.36488715 |
| 31 | MP0001145_abnormal_male_reproductive | 1.31461726 |
| 32 | MP0000313_abnormal_cell_death | 1.30172093 |
| 33 | MP0006035_abnormal_mitochondrial_morpho | 1.29841099 |
| 34 | MP0001986_abnormal_taste_sensitivity | 1.28744970 |
| 35 | MP0001697_abnormal_embryo_size | 1.27664651 |
| 36 | MP0008789_abnormal_olfactory_epithelium | 1.27014318 |
| 37 | MP0009379_abnormal_foot_pigmentation | 1.26829991 |
| 38 | MP0003186_abnormal_redox_activity | 1.26300803 |
| 39 | MP0005389_reproductive_system_phenotype | 1.26090940 |
| 40 | MP0000490_abnormal_crypts_of | 1.25869476 |
| 41 | MP0002080_prenatal_lethality | 1.25395882 |
| 42 | MP0000749_muscle_degeneration | 1.24148348 |
| 43 | MP0001929_abnormal_gametogenesis | 1.23385788 |
| 44 | MP0009333_abnormal_splenocyte_physiolog | 1.22201314 |
| 45 | MP0006036_abnormal_mitochondrial_physio | 1.19910080 |
| 46 | MP0002751_abnormal_autonomic_nervous | 1.15250994 |
| 47 | MP0003937_abnormal_limbs/digits/tail_de | 1.15044169 |
| 48 | MP0005380_embryogenesis_phenotype | 1.12780497 |
| 49 | MP0001672_abnormal_embryogenesis/_devel | 1.12780497 |
| 50 | MP0002019_abnormal_tumor_incidence | 1.09706223 |
| 51 | MP0002132_abnormal_respiratory_system | 1.09631020 |
| 52 | MP0000653_abnormal_sex_gland | 1.09311915 |
| 53 | MP0000358_abnormal_cell_content/ | 1.09075556 |
| 54 | MP0002095_abnormal_skin_pigmentation | 1.09058730 |
| 55 | MP0003646_muscle_fatigue | 1.08836602 |
| 56 | MP0001293_anophthalmia | 1.06783805 |
| 57 | MP0004133_heterotaxia | 1.06669943 |
| 58 | MP0009697_abnormal_copulation | 1.06477948 |
| 59 | MP0010307_abnormal_tumor_latency | 1.03562847 |
| 60 | MP0002233_abnormal_nose_morphology | 1.03559016 |
| 61 | MP0000372_irregular_coat_pigmentation | 0.99768063 |
| 62 | MP0003890_abnormal_embryonic-extraembry | 0.99479864 |
| 63 | MP0002085_abnormal_embryonic_tissue | 0.98941328 |
| 64 | MP0001905_abnormal_dopamine_level | 0.93812202 |
| 65 | MP0005330_cardiomyopathy | 0.91655260 |
| 66 | MP0003984_embryonic_growth_retardation | 0.90951677 |
| 67 | MP0001764_abnormal_homeostasis | 0.90886060 |
| 68 | MP0005084_abnormal_gallbladder_morpholo | 0.90321825 |
| 69 | MP0000015_abnormal_ear_pigmentation | 0.89938158 |
| 70 | MP0003136_yellow_coat_color | 0.89472522 |
| 71 | MP0002090_abnormal_vision | 0.89423829 |
| 72 | MP0000647_abnormal_sebaceous_gland | 0.88633615 |
| 73 | MP0004808_abnormal_hematopoietic_stem | 0.88408282 |
| 74 | MP0001727_abnormal_embryo_implantation | 0.88122643 |
| 75 | MP0002088_abnormal_embryonic_growth/wei | 0.87970466 |
| 76 | MP0002084_abnormal_developmental_patter | 0.86570679 |
| 77 | MP0001919_abnormal_reproductive_system | 0.86455729 |
| 78 | MP0005408_hypopigmentation | 0.86335475 |
| 79 | MP0009672_abnormal_birth_weight | 0.85985817 |
| 80 | MP0002638_abnormal_pupillary_reflex | 0.85930686 |
| 81 | MP0005174_abnormal_tail_pigmentation | 0.84468500 |
| 82 | MP0003698_abnormal_male_reproductive | 0.84073800 |
| 83 | MP0001286_abnormal_eye_development | 0.82598972 |
| 84 | MP0003950_abnormal_plasma_membrane | 0.82244456 |
| 85 | MP0001346_abnormal_lacrimal_gland | 0.81993687 |
| 86 | MP0003011_delayed_dark_adaptation | 0.81107413 |
| 87 | MP0006072_abnormal_retinal_apoptosis | 0.80996527 |
| 88 | MP0004147_increased_porphyrin_level | 0.80859486 |
| 89 | MP0002736_abnormal_nociception_after | 0.80575296 |
| 90 | MP0005394_taste/olfaction_phenotype | 0.78723883 |
| 91 | MP0005499_abnormal_olfactory_system | 0.78723883 |
| 92 | MP0002653_abnormal_ependyma_morphology | 0.78677015 |
| 93 | MP0003221_abnormal_cardiomyocyte_apopto | 0.78244551 |
| 94 | MP0005266_abnormal_metabolism | 0.77874079 |
| 95 | MP0001119_abnormal_female_reproductive | 0.76587994 |
| 96 | MP0001545_abnormal_hematopoietic_system | 0.76402934 |
| 97 | MP0005397_hematopoietic_system_phenotyp | 0.76402934 |
| 98 | MP0001542_abnormal_bone_strength | 0.75871252 |
| 99 | MP0002111_abnormal_tail_morphology | 0.75476880 |
| 100 | MP0003938_abnormal_ear_development | 0.75118078 |
| 101 | MP0000703_abnormal_thymus_morphology | 0.74389525 |
| 102 | MP0004215_abnormal_myocardial_fiber | 0.74305281 |
| 103 | MP0003567_abnormal_fetal_cardiomyocyte | 0.72985322 |
| 104 | MP0008995_early_reproductive_senescence | 0.72682611 |
| 105 | MP0003119_abnormal_digestive_system | 0.72679953 |
| 106 | MP0005379_endocrine/exocrine_gland_phen | 0.69878351 |
| 107 | MP0002722_abnormal_immune_system | 0.69857297 |
| 108 | MP0002697_abnormal_eye_size | 0.69711656 |
| 109 | MP0001881_abnormal_mammary_gland | 0.69609994 |
| 110 | MP0005384_cellular_phenotype | 0.69308901 |
| 111 | MP0002398_abnormal_bone_marrow | 0.69230117 |
| 112 | MP0003941_abnormal_skin_development | 0.68970515 |
| 113 | MP0002163_abnormal_gland_morphology | 0.68904907 |
| 114 | MP0002277_abnormal_respiratory_mucosa | 0.68317679 |
| 115 | MP0001186_pigmentation_phenotype | 0.67655206 |
| 116 | MP0000689_abnormal_spleen_morphology | 0.66815968 |
| 117 | MP0002086_abnormal_extraembryonic_tissu | 0.66671692 |
| 118 | MP0000049_abnormal_middle_ear | 0.64981864 |
| 119 | MP0006276_abnormal_autonomic_nervous | 0.64903917 |
| 120 | MP0003755_abnormal_palate_morphology | 0.64427946 |
| 121 | MP0005671_abnormal_response_to | 0.63550486 |
| 122 | MP0000681_abnormal_thyroid_gland | 0.62469248 |
| 123 | MP0005253_abnormal_eye_physiology | 0.62382333 |
| 124 | MP0000762_abnormal_tongue_morphology | 0.62337121 |
| 125 | MP0004197_abnormal_fetal_growth/weight/ | 0.61869251 |
| 126 | MP0002269_muscular_atrophy | 0.61355303 |
| 127 | MP0010030_abnormal_orbit_morphology | 0.60574351 |
| 128 | MP0002075_abnormal_coat/hair_pigmentati | 0.60339000 |
| 129 | MP0002876_abnormal_thyroid_physiology | 0.60076144 |
| 130 | MP0005367_renal/urinary_system_phenotyp | 0.59953188 |
| 131 | MP0000516_abnormal_urinary_system | 0.59953188 |
| 132 | MP0002429_abnormal_blood_cell | 0.59846998 |
| 133 | MP0009250_abnormal_appendicular_skeleto | 0.59628265 |
| 134 | MP0002161_abnormal_fertility/fecundity | 0.58543085 |
| 135 | MP0001661_extended_life_span | 0.58183964 |
| 136 | MP0003122_maternal_imprinting | 0.57876751 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.82991439 |
| 2 | Cerebral hypomyelination (HP:0006808) | 4.11573228 |
| 3 | Breast hypoplasia (HP:0003187) | 3.89532400 |
| 4 | Reticulocytopenia (HP:0001896) | 3.64374689 |
| 5 | Cerebral edema (HP:0002181) | 3.52790450 |
| 6 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.49266462 |
| 7 | Abnormal number of erythroid precursors (HP:0012131) | 3.42493092 |
| 8 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.32542743 |
| 9 | Chromsome breakage (HP:0040012) | 3.29845811 |
| 10 | Renal Fanconi syndrome (HP:0001994) | 3.29732732 |
| 11 | Rough bone trabeculation (HP:0100670) | 3.21101863 |
| 12 | Carpal bone hypoplasia (HP:0001498) | 3.16648251 |
| 13 | Increased intramyocellular lipid droplets (HP:0012240) | 3.15376877 |
| 14 | Abnormality of the anterior horn cell (HP:0006802) | 3.09155012 |
| 15 | Degeneration of anterior horn cells (HP:0002398) | 3.09155012 |
| 16 | Abnormality of the preputium (HP:0100587) | 3.05820763 |
| 17 | Oral leukoplakia (HP:0002745) | 3.05084625 |
| 18 | Type I transferrin isoform profile (HP:0003642) | 3.04066098 |
| 19 | Aplastic anemia (HP:0001915) | 2.98630146 |
| 20 | Meckel diverticulum (HP:0002245) | 2.94536824 |
| 21 | Acute necrotizing encephalopathy (HP:0006965) | 2.94273076 |
| 22 | 3-Methylglutaconic aciduria (HP:0003535) | 2.89118224 |
| 23 | Mitochondrial inheritance (HP:0001427) | 2.86207025 |
| 24 | Abnormality of the ileum (HP:0001549) | 2.82844023 |
| 25 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.78509404 |
| 26 | Abnormality of chromosome stability (HP:0003220) | 2.77177968 |
| 27 | Increased serum lactate (HP:0002151) | 2.76991531 |
| 28 | Increased CSF lactate (HP:0002490) | 2.76847070 |
| 29 | 11 pairs of ribs (HP:0000878) | 2.74436357 |
| 30 | Hepatocellular necrosis (HP:0001404) | 2.73979570 |
| 31 | Macrocytic anemia (HP:0001972) | 2.72509211 |
| 32 | Respiratory failure (HP:0002878) | 2.72491860 |
| 33 | Abnormality of glycolysis (HP:0004366) | 2.71135255 |
| 34 | Increased serum pyruvate (HP:0003542) | 2.71135255 |
| 35 | Respiratory difficulties (HP:0002880) | 2.70456268 |
| 36 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.66567931 |
| 37 | Patellar aplasia (HP:0006443) | 2.62282461 |
| 38 | Bone marrow hypocellularity (HP:0005528) | 2.61225975 |
| 39 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.61167602 |
| 40 | Abnormality of alanine metabolism (HP:0010916) | 2.61167602 |
| 41 | Hyperalaninemia (HP:0003348) | 2.61167602 |
| 42 | Increased muscle lipid content (HP:0009058) | 2.59908918 |
| 43 | Microvesicular hepatic steatosis (HP:0001414) | 2.59541213 |
| 44 | Premature graying of hair (HP:0002216) | 2.58813669 |
| 45 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.53165925 |
| 46 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.53165925 |
| 47 | Microretrognathia (HP:0000308) | 2.52777929 |
| 48 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.51183372 |
| 49 | CNS hypomyelination (HP:0003429) | 2.48987763 |
| 50 | Leukodystrophy (HP:0002415) | 2.48756639 |
| 51 | Increased hepatocellular lipid droplets (HP:0006565) | 2.46929476 |
| 52 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.45974044 |
| 53 | Abnormality of the labia minora (HP:0012880) | 2.41676030 |
| 54 | Abnormal trabecular bone morphology (HP:0100671) | 2.41416014 |
| 55 | Absent radius (HP:0003974) | 2.40830264 |
| 56 | Hepatic necrosis (HP:0002605) | 2.39911657 |
| 57 | Pallor (HP:0000980) | 2.39198315 |
| 58 | Absent thumb (HP:0009777) | 2.38071252 |
| 59 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.35687686 |
| 60 | Duodenal stenosis (HP:0100867) | 2.34924090 |
| 61 | Small intestinal stenosis (HP:0012848) | 2.34924090 |
| 62 | Agnosia (HP:0010524) | 2.33705986 |
| 63 | Exertional dyspnea (HP:0002875) | 2.30578190 |
| 64 | Long foot (HP:0001833) | 2.30241293 |
| 65 | Megaloblastic anemia (HP:0001889) | 2.27186635 |
| 66 | Impulsivity (HP:0100710) | 2.26582877 |
| 67 | Abnormality of methionine metabolism (HP:0010901) | 2.24922778 |
| 68 | Multiple enchondromatosis (HP:0005701) | 2.24729394 |
| 69 | Abnormality of placental membranes (HP:0011409) | 2.24592838 |
| 70 | Amniotic constriction ring (HP:0009775) | 2.24592838 |
| 71 | Absent forearm bone (HP:0003953) | 2.23435542 |
| 72 | Aplasia involving forearm bones (HP:0009822) | 2.23435542 |
| 73 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.22415664 |
| 74 | Pancreatic fibrosis (HP:0100732) | 2.21353894 |
| 75 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.21303250 |
| 76 | Colon cancer (HP:0003003) | 2.21255507 |
| 77 | Pancytopenia (HP:0001876) | 2.20441546 |
| 78 | Methylmalonic acidemia (HP:0002912) | 2.19718479 |
| 79 | Duplicated collecting system (HP:0000081) | 2.19473067 |
| 80 | CNS demyelination (HP:0007305) | 2.18139702 |
| 81 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.17368287 |
| 82 | Progressive macrocephaly (HP:0004481) | 2.17217099 |
| 83 | Horseshoe kidney (HP:0000085) | 2.17131238 |
| 84 | Postnatal microcephaly (HP:0005484) | 2.16976277 |
| 85 | Secondary amenorrhea (HP:0000869) | 2.16078743 |
| 86 | Abnormality of serum amino acid levels (HP:0003112) | 2.15317963 |
| 87 | Lethargy (HP:0001254) | 2.14223475 |
| 88 | Pancreatic cysts (HP:0001737) | 2.14110040 |
| 89 | Reduced antithrombin III activity (HP:0001976) | 2.13428542 |
| 90 | Selective tooth agenesis (HP:0001592) | 2.12561752 |
| 91 | Myelodysplasia (HP:0002863) | 2.12522406 |
| 92 | Methylmalonic aciduria (HP:0012120) | 2.12201192 |
| 93 | Embryonal renal neoplasm (HP:0011794) | 2.11875942 |
| 94 | Supernumerary spleens (HP:0009799) | 2.10771376 |
| 95 | Acute encephalopathy (HP:0006846) | 2.09978200 |
| 96 | Neoplasm of the pancreas (HP:0002894) | 2.08350637 |
| 97 | Hyperglycinemia (HP:0002154) | 2.06772730 |
| 98 | Abnormal lung lobation (HP:0002101) | 2.06759031 |
| 99 | Medulloblastoma (HP:0002885) | 2.05285276 |
| 100 | Optic disc pallor (HP:0000543) | 2.04449121 |
| 101 | Facial cleft (HP:0002006) | 2.03559561 |
| 102 | Sloping forehead (HP:0000340) | 2.02304678 |
| 103 | Cellular immunodeficiency (HP:0005374) | 2.02235668 |
| 104 | Abnormal spermatogenesis (HP:0008669) | 2.01792428 |
| 105 | Lipid accumulation in hepatocytes (HP:0006561) | 2.01428462 |
| 106 | Triphalangeal thumb (HP:0001199) | 2.00269568 |
| 107 | Progressive muscle weakness (HP:0003323) | 1.99099330 |
| 108 | Hypoplasia of the pons (HP:0012110) | 1.98928991 |
| 109 | Lactic acidosis (HP:0003128) | 1.98869966 |
| 110 | Type 2 muscle fiber atrophy (HP:0003554) | 1.98608053 |
| 111 | Exercise intolerance (HP:0003546) | 1.98272378 |
| 112 | Abnormality of the renal collecting system (HP:0004742) | 1.98098387 |
| 113 | Abnormal glycosylation (HP:0012345) | 1.97023850 |
| 114 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.97023850 |
| 115 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.97023850 |
| 116 | Abnormal protein glycosylation (HP:0012346) | 1.97023850 |
| 117 | Abnormality of the duodenum (HP:0002246) | 1.96529954 |
| 118 | Premature ovarian failure (HP:0008209) | 1.95295345 |
| 119 | Ependymoma (HP:0002888) | 1.95103277 |
| 120 | Poor head control (HP:0002421) | 1.93100219 |
| 121 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.92598058 |
| 122 | Neoplasm of the adrenal cortex (HP:0100641) | 1.92090532 |
| 123 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.91725236 |
| 124 | X-linked dominant inheritance (HP:0001423) | 1.88048841 |
| 125 | Emotional lability (HP:0000712) | 1.83335385 |
| 126 | Abnormality of renal resorption (HP:0011038) | 1.82618752 |
| 127 | Sparse eyelashes (HP:0000653) | 1.82425304 |
| 128 | Neoplasm of the colon (HP:0100273) | 1.77987523 |
| 129 | Dicarboxylic aciduria (HP:0003215) | 1.71494962 |
| 130 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.71494962 |
| 131 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.70422052 |
| 132 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.69850781 |
| 133 | Neoplasm of the adrenal gland (HP:0100631) | 1.68444140 |
| 134 | Abnormality of the umbilical cord (HP:0010881) | 1.64513717 |
| 135 | Spastic diplegia (HP:0001264) | 1.63466703 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.80955885 |
| 2 | VRK2 | 4.44859811 |
| 3 | WEE1 | 4.27916318 |
| 4 | EIF2AK1 | 3.18563911 |
| 5 | TSSK6 | 3.10423582 |
| 6 | SRPK1 | 2.57766297 |
| 7 | * STK16 | 2.56770453 |
| 8 | PLK4 | 2.55819574 |
| 9 | VRK1 | 2.54283844 |
| 10 | CDC7 | 2.53094017 |
| 11 | EIF2AK3 | 2.45984426 |
| 12 | TRIM28 | 2.34674804 |
| 13 | BRSK2 | 2.23938927 |
| 14 | ACVR1B | 2.21587213 |
| 15 | NEK1 | 2.06607533 |
| 16 | MKNK1 | 2.06488057 |
| 17 | ZAK | 2.02243217 |
| 18 | NUAK1 | 1.96592159 |
| 19 | MKNK2 | 1.90807746 |
| 20 | CCNB1 | 1.89131326 |
| 21 | PLK3 | 1.80497918 |
| 22 | TTK | 1.72049515 |
| 23 | PLK1 | 1.71053816 |
| 24 | NEK2 | 1.58573171 |
| 25 | TLK1 | 1.56070251 |
| 26 | NME2 | 1.51133313 |
| 27 | EPHA2 | 1.50353648 |
| 28 | NME1 | 1.50278434 |
| 29 | TAF1 | 1.47784978 |
| 30 | BRAF | 1.45309408 |
| 31 | BRSK1 | 1.44780988 |
| 32 | DYRK3 | 1.44264718 |
| 33 | PASK | 1.37840330 |
| 34 | MAP3K12 | 1.36935888 |
| 35 | PIM2 | 1.30379793 |
| 36 | ATR | 1.29939795 |
| 37 | TESK2 | 1.29543055 |
| 38 | AKT3 | 1.27372474 |
| 39 | AURKB | 1.18899680 |
| 40 | MAP4K2 | 1.15671445 |
| 41 | CASK | 1.15187687 |
| 42 | AURKA | 1.12929446 |
| 43 | PNCK | 1.12758932 |
| 44 | CDK7 | 1.12522589 |
| 45 | CHEK2 | 1.11449702 |
| 46 | ARAF | 1.09007068 |
| 47 | EIF2AK2 | 1.08673048 |
| 48 | CDK8 | 1.07125197 |
| 49 | MST4 | 1.06299782 |
| 50 | RPS6KB2 | 1.03936691 |
| 51 | IRAK3 | 0.98553851 |
| 52 | CSNK1G1 | 0.83537409 |
| 53 | DAPK1 | 0.79630985 |
| 54 | CDK19 | 0.79167428 |
| 55 | PRKCI | 0.79004249 |
| 56 | TGFBR1 | 0.78548257 |
| 57 | DYRK2 | 0.78211721 |
| 58 | CHEK1 | 0.74390075 |
| 59 | IRAK4 | 0.72738467 |
| 60 | PAK4 | 0.72564928 |
| 61 | CSNK2A1 | 0.71232590 |
| 62 | CSNK1A1L | 0.70806636 |
| 63 | TESK1 | 0.70210559 |
| 64 | ADRBK2 | 0.70076188 |
| 65 | CSNK1G2 | 0.67296207 |
| 66 | CSNK2A2 | 0.66563429 |
| 67 | PDK3 | 0.66557639 |
| 68 | PDK4 | 0.66557639 |
| 69 | BMPR1B | 0.65345402 |
| 70 | ABL2 | 0.64879175 |
| 71 | LIMK1 | 0.61688720 |
| 72 | BCR | 0.61032755 |
| 73 | OBSCN | 0.60346972 |
| 74 | KDR | 0.60306354 |
| 75 | PBK | 0.59282826 |
| 76 | MAP3K8 | 0.57596362 |
| 77 | SIK3 | 0.54798656 |
| 78 | PAK1 | 0.54773880 |
| 79 | BLK | 0.52427746 |
| 80 | RPS6KA4 | 0.51475670 |
| 81 | RPS6KA5 | 0.50823960 |
| 82 | BCKDK | 0.50643654 |
| 83 | CDK4 | 0.50542694 |
| 84 | PHKG2 | 0.50236489 |
| 85 | PHKG1 | 0.50236489 |
| 86 | ATM | 0.47996060 |
| 87 | ERBB4 | 0.47271096 |
| 88 | PDK2 | 0.46913882 |
| 89 | MYLK | 0.44865572 |
| 90 | CDK2 | 0.44440774 |
| 91 | CSNK1G3 | 0.44063999 |
| 92 | MAP2K7 | 0.43972790 |
| 93 | YES1 | 0.42611400 |
| 94 | CAMK2B | 0.41787686 |
| 95 | MINK1 | 0.40081623 |
| 96 | DAPK3 | 0.39981299 |
| 97 | MAPKAPK5 | 0.39392511 |
| 98 | CDK1 | 0.38116278 |
| 99 | TXK | 0.36814660 |
| 100 | OXSR1 | 0.36254967 |
| 101 | PLK2 | 0.35754078 |
| 102 | MARK1 | 0.35375729 |
| 103 | CAMKK2 | 0.34907965 |
| 104 | WNK3 | 0.34386617 |
| 105 | BRD4 | 0.33868089 |
| 106 | ALK | 0.33198259 |
| 107 | STK4 | 0.33127255 |
| 108 | CDK9 | 0.32827843 |
| 109 | TEC | 0.31892343 |
| 110 | CLK1 | 0.31727360 |
| 111 | AKT2 | 0.31117686 |
| 112 | PIM1 | 0.30741154 |
| 113 | STK38L | 0.30147532 |
| 114 | TNIK | 0.29735936 |
| 115 | GRK1 | 0.28690446 |
| 116 | MUSK | 0.28684457 |
| 117 | ERBB3 | 0.27451511 |
| 118 | INSRR | 0.27184761 |
| 119 | CDK3 | 0.26977333 |
| 120 | CSNK1A1 | 0.26915480 |
| 121 | STK24 | 0.25812033 |
| 122 | NEK6 | 0.23256219 |
| 123 | SCYL2 | 0.22762785 |
| 124 | PRKG2 | 0.19891141 |
| 125 | CSNK1E | 0.19755084 |
| 126 | ILK | 0.19700966 |
| 127 | CAMK2G | 0.18084745 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.93969075 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.46706919 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.93517975 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.80979364 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 3.59190236 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.55353644 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.05250226 |
| 8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.87313863 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.80995517 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.79633539 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.76325402 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.73379123 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.56651617 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.19983908 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.19971730 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.17365501 |
| 17 | Protein export_Homo sapiens_hsa03060 | 1.93013464 |
| 18 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.82930628 |
| 19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.82305609 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.80913850 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.72614164 |
| 22 | Purine metabolism_Homo sapiens_hsa00230 | 1.72431399 |
| 23 | Parkinsons disease_Homo sapiens_hsa05012 | 1.67307593 |
| 24 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.59374139 |
| 25 | Huntingtons disease_Homo sapiens_hsa05016 | 1.50253965 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.48481300 |
| 27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.38913609 |
| 28 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.35473507 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.27662199 |
| 30 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.20087716 |
| 31 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.19173376 |
| 32 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.18995964 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.18298490 |
| 34 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.12298831 |
| 35 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.11920690 |
| 36 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.02426246 |
| 37 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.97834398 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.93195934 |
| 39 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.91244257 |
| 40 | Alzheimers disease_Homo sapiens_hsa05010 | 0.90240441 |
| 41 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.88938692 |
| 42 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.88650148 |
| 43 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.88395061 |
| 44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.86229081 |
| 45 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.84763834 |
| 46 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.83099002 |
| 47 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.73817070 |
| 48 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.73798700 |
| 49 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.68927307 |
| 50 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.68735048 |
| 51 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.67738092 |
| 52 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.67216573 |
| 53 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.66606678 |
| 54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.66081613 |
| 55 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.65288470 |
| 56 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.64210475 |
| 57 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.62301612 |
| 58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.62194474 |
| 59 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.59627832 |
| 60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.58556915 |
| 61 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57596207 |
| 62 | Peroxisome_Homo sapiens_hsa04146 | 0.57115160 |
| 63 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.56914212 |
| 64 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.56113562 |
| 65 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.55175160 |
| 66 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.53486885 |
| 67 | Metabolic pathways_Homo sapiens_hsa01100 | 0.52431206 |
| 68 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.51917213 |
| 69 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.51853173 |
| 70 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.51607946 |
| 71 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.51446637 |
| 72 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.50546159 |
| 73 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.49071944 |
| 74 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.48252664 |
| 75 | Carbon metabolism_Homo sapiens_hsa01200 | 0.44727650 |
| 76 | Alcoholism_Homo sapiens_hsa05034 | 0.42967666 |
| 77 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.41830856 |
| 78 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.40710206 |
| 79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.40647861 |
| 80 | Legionellosis_Homo sapiens_hsa05134 | 0.39168410 |
| 81 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.38123871 |
| 82 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.37030187 |
| 83 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.34324203 |
| 84 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.34154981 |
| 85 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.32354579 |
| 86 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.31769000 |
| 87 | Sulfur relay system_Homo sapiens_hsa04122 | 0.29235566 |
| 88 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.28508811 |
| 89 | HTLV-I infection_Homo sapiens_hsa05166 | 0.26469635 |
| 90 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.25024221 |
| 91 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.24032689 |
| 92 | Asthma_Homo sapiens_hsa05310 | 0.23664083 |
| 93 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.22393691 |
| 94 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.22285590 |
| 95 | Allograft rejection_Homo sapiens_hsa05330 | 0.21178338 |
| 96 | Phototransduction_Homo sapiens_hsa04744 | 0.19331914 |
| 97 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.18521558 |
| 98 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.18418472 |
| 99 | Galactose metabolism_Homo sapiens_hsa00052 | 0.18324421 |
| 100 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.18267547 |
| 101 | Phagosome_Homo sapiens_hsa04145 | 0.18250959 |
| 102 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.17293768 |
| 103 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.17174257 |
| 104 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.16803183 |
| 105 | Other glycan degradation_Homo sapiens_hsa00511 | 0.16197951 |
| 106 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.15982355 |
| 107 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.13363539 |
| 108 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.13062479 |
| 109 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.11824424 |
| 110 | Thyroid cancer_Homo sapiens_hsa05216 | 0.11042972 |
| 111 | Measles_Homo sapiens_hsa05162 | 0.10717211 |
| 112 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.10456524 |
| 113 | Shigellosis_Homo sapiens_hsa05131 | 0.07108293 |
| 114 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.06726499 |
| 115 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.06726027 |
| 116 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.06603275 |
| 117 | Apoptosis_Homo sapiens_hsa04210 | 0.06536779 |
| 118 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.04305207 |
| 119 | Lysine degradation_Homo sapiens_hsa00310 | 0.04177947 |
| 120 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.04110274 |
| 121 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.04049978 |
| 122 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.03869201 |
| 123 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.03756176 |
| 124 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.03626204 |
| 125 | Retinol metabolism_Homo sapiens_hsa00830 | 0.02745602 |
| 126 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.02736573 |
| 127 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.02720787 |
| 128 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.01667771 |
| 129 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.00384591 |
| 130 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.00112970 |

