DRICH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.26553857
2sperm capacitation (GO:0048240)9.07309896
3DNA packaging (GO:0006323)8.93198548
4response to pheromone (GO:0019236)8.51810303
5plasma membrane fusion (GO:0045026)8.35204823
6spermatid development (GO:0007286)8.20577898
7microtubule depolymerization (GO:0007019)7.93124216
8spermatid nucleus differentiation (GO:0007289)7.85198838
9single strand break repair (GO:0000012)7.71460612
10sperm-egg recognition (GO:0035036)7.44420807
11protein targeting to Golgi (GO:0000042)7.31198955
12rRNA methylation (GO:0031167)7.02771418
13establishment of protein localization to Golgi (GO:0072600)7.02517045
14multicellular organism reproduction (GO:0032504)7.00464471
15binding of sperm to zona pellucida (GO:0007339)6.92773475
16protein polyglutamylation (GO:0018095)6.86423518
17retrograde transport, vesicle recycling within Golgi (GO:0000301)6.84238245
18microtubule polymerization or depolymerization (GO:0031109)6.71347536
19reproduction (GO:0000003)6.62273399
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.56059133
21sexual reproduction (GO:0019953)6.50251550
22calcium ion-dependent exocytosis (GO:0017156)6.49916490
23negative regulation of inclusion body assembly (GO:0090084)6.34331181
24axonemal dynein complex assembly (GO:0070286)6.30885329
25spermatogenesis (GO:0007283)6.19795727
26male gamete generation (GO:0048232)6.17559951
27cell-cell recognition (GO:0009988)6.17135390
28phosphatidylethanolamine metabolic process (GO:0046337)6.04972234
29centriole replication (GO:0007099)5.86764373
30rRNA modification (GO:0000154)5.84530911
31microtubule severing (GO:0051013)5.82321199
32gamete generation (GO:0007276)5.66279759
33centriole assembly (GO:0098534)5.33119269
34positive regulation of Rab GTPase activity (GO:0032851)5.29144132
35regulation of Rab GTPase activity (GO:0032313)5.29144132
36motile cilium assembly (GO:0044458)5.21109579
37protein localization to Golgi apparatus (GO:0034067)5.20006670
38single fertilization (GO:0007338)5.11416627
39cilium or flagellum-dependent cell motility (GO:0001539)5.02525246
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97485543
41cellular ketone body metabolic process (GO:0046950)4.95674537
42regulation of cilium movement (GO:0003352)4.89932866
43RNA destabilization (GO:0050779)4.78356626
44germ cell development (GO:0007281)4.71174926
45cell wall macromolecule catabolic process (GO:0016998)4.63726334
46regulation of centriole replication (GO:0046599)4.62064903
47multicellular organismal reproductive process (GO:0048609)4.55550174
48regulation of transcription involved in cell fate commitment (GO:0060850)4.55230086
49cell wall macromolecule metabolic process (GO:0044036)4.51014446
50seminiferous tubule development (GO:0072520)4.50852023
51cellular process involved in reproduction in multicellular organism (GO:0022412)4.49145240
52regulation of inclusion body assembly (GO:0090083)4.42699511
53chromatin silencing (GO:0006342)4.39859951
54ketone body metabolic process (GO:1902224)4.35324330
55fertilization (GO:0009566)4.28731744
56nucleus organization (GO:0006997)4.18522438
57epithelial cilium movement (GO:0003351)4.14318130
58glycerol ether metabolic process (GO:0006662)4.05032992
59organic cation transport (GO:0015695)3.83346993
60multicellular organismal movement (GO:0050879)3.81850522
61musculoskeletal movement (GO:0050881)3.81850522
62negative regulation of Rho protein signal transduction (GO:0035024)3.73699212
63ether metabolic process (GO:0018904)3.72669235
64nucleosome disassembly (GO:0006337)3.70406625
65protein-DNA complex disassembly (GO:0032986)3.70406625
66coenzyme catabolic process (GO:0009109)3.70039064
67microtubule nucleation (GO:0007020)3.69699389
68cilium movement (GO:0003341)3.63126600
69polyamine biosynthetic process (GO:0006596)3.61798185
70regulation of phosphoprotein phosphatase activity (GO:0043666)3.50796885
71response to acidic pH (GO:0010447)3.48787537
72regulation of T-helper 2 cell differentiation (GO:0045628)3.42526077
73histone H3-K9 demethylation (GO:0033169)3.41988078
74regulation of somitogenesis (GO:0014807)3.41965520
75regulation of microtubule-based movement (GO:0060632)3.39296809
76glomerular visceral epithelial cell development (GO:0072015)3.34711175
77cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.27907708
78cellular response to pH (GO:0071467)3.25939630
79glomerular epithelial cell development (GO:0072310)3.22404476
80regulation of interleukin-13 production (GO:0032656)3.21640278
81homeostasis of number of cells within a tissue (GO:0048873)3.16996333
82membrane protein intracellular domain proteolysis (GO:0031293)3.15331517
83cerebral cortex neuron differentiation (GO:0021895)3.14301556
84negative regulation of gene expression, epigenetic (GO:0045814)3.10098697
85multicellular organismal development (GO:0007275)3.03142495
86peptidyl-threonine dephosphorylation (GO:0035970)3.02655204
87protein depolymerization (GO:0051261)3.01577906
88receptor recycling (GO:0001881)3.01374008
89regulation of ARF GTPase activity (GO:0032312)2.95815431
90cranial nerve morphogenesis (GO:0021602)2.90499455
91cell recognition (GO:0008037)2.90437553
92DNA conformation change (GO:0071103)2.87768927
93ventricular system development (GO:0021591)2.84181577
94Golgi to endosome transport (GO:0006895)2.79390643
95male meiosis (GO:0007140)2.75192259
96intra-Golgi vesicle-mediated transport (GO:0006891)2.70088813
97detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.68470580
98acrosome reaction (GO:0007340)11.9969852
99sperm motility (GO:0030317)11.9903003
100fusion of sperm to egg plasma membrane (GO:0007342)11.0446999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02002464
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.85983218
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.67903564
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44695158
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.44695158
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.39112829
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.20614941
8CBP_20019798_ChIP-Seq_JUKART_Human2.20614941
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.16715714
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16395348
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03072301
12RAC3_21632823_ChIP-Seq_H3396_Human1.97461553
13ERA_21632823_ChIP-Seq_H3396_Human1.96354194
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92351472
15DROSHA_22980978_ChIP-Seq_HELA_Human1.88840591
16NANOG_20526341_ChIP-Seq_ESCs_Human1.85637279
17EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.84924171
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.84818995
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.83914544
20FUS_26573619_Chip-Seq_HEK293_Human1.81809361
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.81497959
22EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.81491592
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78000313
24SMC4_20622854_ChIP-Seq_HELA_Human1.76294201
25BCL6_27268052_Chip-Seq_Bcells_Human1.74262038
26CTCF_27219007_Chip-Seq_Bcells_Human1.72252123
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70434127
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.63904929
29EZH2_22144423_ChIP-Seq_EOC_Human1.62276279
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61992617
31MYC_19829295_ChIP-Seq_ESCs_Human1.60482662
32BCOR_27268052_Chip-Seq_Bcells_Human1.59444642
33ER_23166858_ChIP-Seq_MCF-7_Human1.59043289
34E2F1_20622854_ChIP-Seq_HELA_Human1.58520524
35P68_20966046_ChIP-Seq_HELA_Human1.58434633
36YY1_22570637_ChIP-Seq_MALME-3M_Human1.57825465
37TAF2_19829295_ChIP-Seq_ESCs_Human1.56375665
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54459888
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53902191
40OCT4_20526341_ChIP-Seq_ESCs_Human1.53116193
41PHF8_20622854_ChIP-Seq_HELA_Human1.52617481
42CTCF_20526341_ChIP-Seq_ESCs_Human1.51445400
43LXR_22292898_ChIP-Seq_THP-1_Human1.50494005
44TP63_22573176_ChIP-Seq_HFKS_Human1.49412226
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47146996
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45132629
47RUNX_20019798_ChIP-Seq_JUKART_Human1.43452382
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.40410962
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39170415
50P300_27268052_Chip-Seq_Bcells_Human1.39077823
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38666962
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38230086
53ERG_20517297_ChIP-Seq_VCAP_Human1.36757546
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34053908
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33649935
56TP53_18474530_ChIP-ChIP_U2OS_Human1.32302288
57HNFA_21074721_ChIP-Seq_CACO-2_Human1.31676513
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30637135
59AR_25329375_ChIP-Seq_VCAP_Human1.28967165
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28850781
61RBPJ_21746931_ChIP-Seq_IB4_Human1.27467689
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27135671
63CEBPB_22108803_ChIP-Seq_LS180_Human1.26764275
64P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26653139
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23298033
66ETV1_20927104_ChIP-Seq_GIST48_Human1.21804582
67SMAD3_21741376_ChIP-Seq_ESCs_Human1.21656266
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.21018069
69SOX2_22085726_ChIP-Seq_NPCs_Mouse1.19280509
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.18355231
71TBL1_22424771_ChIP-Seq_293T_Human1.16865281
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16720926
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14711156
74NFYB_21822215_ChIP-Seq_K562_Human1.13771714
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13396759
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.12943094
77SMRT_27268052_Chip-Seq_Bcells_Human1.11596224
78P300_19829295_ChIP-Seq_ESCs_Human1.09938978
79VDR_24787735_ChIP-Seq_THP-1_Human1.09899400
80SA1_27219007_Chip-Seq_Bcells_Human1.09351602
81P53_21459846_ChIP-Seq_SAOS-2_Human1.09164211
82AR_21572438_ChIP-Seq_LNCaP_Human1.04638936
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04207055
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03649762
85GATA6_21074721_ChIP-Seq_CACO-2_Human1.03599330
86PHF8_20622853_ChIP-Seq_HELA_Human1.03545201
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.03414485
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02701213
89OCT1_27270436_Chip-Seq_PROSTATE_Human1.02273682
90RUNX2_22187159_ChIP-Seq_PCA_Human1.02259927
91SPI1_20517297_ChIP-Seq_HL60_Human1.01332459
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00667754
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00586254
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00132093
95OCT4_19829295_ChIP-Seq_ESCs_Human0.98102963
96RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98088257
97GF1_26923725_Chip-Seq_HPCs_Mouse0.97604522
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.97381788
99KLF5_25053715_ChIP-Seq_YYC3_Human0.96322213
100KLF4_19829295_ChIP-Seq_ESCs_Human0.95809037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.38158163
2MP0003878_abnormal_ear_physiology5.38158163
3MP0005670_abnormal_white_adipose4.56204100
4MP0003698_abnormal_male_reproductive4.50125802
5MP0001929_abnormal_gametogenesis3.89792040
6MP0001348_abnormal_lacrimal_gland3.33312373
7MP0000678_abnormal_parathyroid_gland2.60957801
8MP0002161_abnormal_fertility/fecundity2.49766242
9MP0002132_abnormal_respiratory_system2.27600725
10MP0003718_maternal_effect2.11142465
11MP0005410_abnormal_fertilization12.6853216
12MP0003646_muscle_fatigue1.83505668
13MP0005451_abnormal_body_composition1.79720681
14MP0002210_abnormal_sex_determination1.65453750
15MP0005310_abnormal_salivary_gland1.61987370
16MP0005379_endocrine/exocrine_gland_phen1.60122746
17MP0002249_abnormal_larynx_morphology1.50709957
18MP0001485_abnormal_pinna_reflex1.50266628
19MP0003011_delayed_dark_adaptation1.49947047
20MP0005423_abnormal_somatic_nervous1.46956508
21MP0004510_myositis1.44699071
22MP0001486_abnormal_startle_reflex1.41793758
23MP0001145_abnormal_male_reproductive1.40021915
24MP0000653_abnormal_sex_gland1.31523879
25MP0002234_abnormal_pharynx_morphology1.31150159
26MP0002138_abnormal_hepatobiliary_system1.28729485
27MP0002822_catalepsy1.27328049
28MP0003879_abnormal_hair_cell1.27028656
29MP0004742_abnormal_vestibular_system1.22459987
30MP0002282_abnormal_trachea_morphology1.22072197
31MP0004859_abnormal_synaptic_plasticity1.21236709
32MP0005248_abnormal_Harderian_gland1.18880834
33MP0001765_abnormal_ion_homeostasis1.16291719
34MP0002127_abnormal_cardiovascular_syste1.09854285
35MP0009053_abnormal_anal_canal1.04894915
36MP0001963_abnormal_hearing_physiology1.03993619
37MP0000534_abnormal_ureter_morphology1.01946123
38MP0005395_other_phenotype1.00665597
39MP0002735_abnormal_chemical_nociception0.96459574
40MP0008877_abnormal_DNA_methylation0.94255146
41MP0001968_abnormal_touch/_nociception0.94025770
42MP0000026_abnormal_inner_ear0.88414849
43MP0000681_abnormal_thyroid_gland0.88093038
44MP0009115_abnormal_fat_cell0.86012879
45MP0005666_abnormal_adipose_tissue0.81664691
46MP0002229_neurodegeneration0.81318448
47MP0005167_abnormal_blood-brain_barrier0.81313224
48MP0005375_adipose_tissue_phenotype0.73404230
49MP0000955_abnormal_spinal_cord0.73131683
50MP0009697_abnormal_copulation0.72175323
51MP0008569_lethality_at_weaning0.68641876
52MP0001905_abnormal_dopamine_level0.67450180
53MP0004484_altered_response_of0.65895401
54MP0005083_abnormal_biliary_tract0.65830502
55MP0002067_abnormal_sensory_capabilities0.63592853
56MP0000003_abnormal_adipose_tissue0.62793397
57MP0009278_abnormal_bone_marrow0.62424346
58MP0008995_early_reproductive_senescence0.60559781
59MP0005636_abnormal_mineral_homeostasis0.60452406
60MP0005551_abnormal_eye_electrophysiolog0.59755771
61MP0004085_abnormal_heartbeat0.58871830
62MP0005397_hematopoietic_system_phenotyp0.56827404
63MP0001545_abnormal_hematopoietic_system0.56827404
64MP0001666_abnormal_nutrient_absorption0.56437899
65MP0005367_renal/urinary_system_phenotyp0.55228792
66MP0000516_abnormal_urinary_system0.55228792
67MP0001879_abnormal_lymphatic_vessel0.53877940
68MP0002733_abnormal_thermal_nociception0.53532418
69MP0002557_abnormal_social/conspecific_i0.53078333
70MP0004233_abnormal_muscle_weight0.52331555
71MP0000049_abnormal_middle_ear0.50461821
72MP0000249_abnormal_blood_vessel0.50393768
73MP0005253_abnormal_eye_physiology0.50004978
74MP0003172_abnormal_lysosome_physiology0.48898358
75MP0005535_abnormal_body_temperature0.48878794
76MP0001984_abnormal_olfaction0.48799474
77MP0002653_abnormal_ependyma_morphology0.46754571
78MP0005647_abnormal_sex_gland0.46507535
79MP0003631_nervous_system_phenotype0.44756499
80MP0003077_abnormal_cell_cycle0.43235881
81MP0002572_abnormal_emotion/affect_behav0.42868529
82MP0000470_abnormal_stomach_morphology0.42759548
83MP0005166_decreased_susceptibility_to0.40435077
84MP0001501_abnormal_sleep_pattern0.38711142
85MP0008004_abnormal_stomach_pH0.38563728
86MP0001270_distended_abdomen0.37814097
87MP0000230_abnormal_systemic_arterial0.37627911
88MP0009764_decreased_sensitivity_to0.37594802
89MP0003699_abnormal_female_reproductive0.37523490
90MP0003632_abnormal_nervous_system0.37093608
91MP0002272_abnormal_nervous_system0.36622527
92MP0001440_abnormal_grooming_behavior0.36340420
93MP0008961_abnormal_basal_metabolism0.36264431
94MP0003137_abnormal_impulse_conducting0.35714893
95MP0000613_abnormal_salivary_gland0.35145721
96MP0001970_abnormal_pain_threshold0.35034162
97MP0001873_stomach_inflammation0.34939863
98MP0004036_abnormal_muscle_relaxation0.34393161
99MP0008874_decreased_physiological_sensi0.34366344
100MP0003936_abnormal_reproductive_system0.34116679

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.88765940
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.28941880
3Absent/shortened dynein arms (HP:0200106)6.28941880
4Asymmetric septal hypertrophy (HP:0001670)5.80163965
5Resting tremor (HP:0002322)5.25398946
6Tubulointerstitial nephritis (HP:0001970)5.20897942
7Attenuation of retinal blood vessels (HP:0007843)4.88029806
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.87920821
9Bony spicule pigmentary retinopathy (HP:0007737)4.83345664
10Abnormal ciliary motility (HP:0012262)4.79778540
11Chronic hepatic failure (HP:0100626)4.69827873
12Abnormal respiratory motile cilium physiology (HP:0012261)4.69662016
13Nasal polyposis (HP:0100582)4.51690701
14Infertility (HP:0000789)4.42628142
15Abnormal respiratory epithelium morphology (HP:0012253)4.40309571
16Abnormal respiratory motile cilium morphology (HP:0005938)4.40309571
17Male infertility (HP:0003251)4.38146747
18Hyperkalemia (HP:0002153)4.27314009
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.14154216
20Abnormality of macular pigmentation (HP:0008002)4.04930476
21Bell-shaped thorax (HP:0001591)3.97519285
22Cone-rod dystrophy (HP:0000548)3.93941188
23Abnormal rod and cone electroretinograms (HP:0008323)3.91635206
24Abnormality of the nasal mucosa (HP:0000433)3.73097402
25Hypoplastic ischia (HP:0003175)3.70739154
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.69432728
27Hypoplasia of the thymus (HP:0000778)3.68917782
28Potter facies (HP:0002009)3.68607498
29Facial shape deformation (HP:0011334)3.68607498
30Enlarged epiphyses (HP:0010580)3.57529311
31Impulsivity (HP:0100710)3.44548336
32Postural instability (HP:0002172)3.42047190
33Abnormality of the ischium (HP:0003174)3.28578974
34Menstrual irregularities (HP:0000858)3.27832816
35Abnormal spermatogenesis (HP:0008669)3.18525184
36Progressive sensorineural hearing impairment (HP:0000408)3.16689477
37Hypoalphalipoproteinemia (HP:0003233)3.03409513
38Azoospermia (HP:0000027)3.02055026
39Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.94108141
40Amelogenesis imperfecta (HP:0000705)2.85849299
41Abnormality of dental color (HP:0011073)2.81444865
42Truncal obesity (HP:0001956)2.74969997
43Abnormality of the costochondral junction (HP:0000919)2.72817004
44Abnormality of the aortic arch (HP:0012303)2.68543196
45Abnormal urine output (HP:0012590)2.66548130
46Rhinitis (HP:0012384)2.61672599
47Unilateral renal agenesis (HP:0000122)2.60696166
48Progressive cerebellar ataxia (HP:0002073)2.60491094
49Portal hypertension (HP:0001409)2.57736760
50Renovascular hypertension (HP:0100817)2.56837931
51Stage 5 chronic kidney disease (HP:0003774)2.56406871
52Double outlet right ventricle (HP:0001719)2.50273376
53Congenital malformation of the right heart (HP:0011723)2.50273376
54Generalized aminoaciduria (HP:0002909)2.49894332
55Abnormality of potassium homeostasis (HP:0011042)2.43901727
56Nephronophthisis (HP:0000090)2.43453118
57Insulin-resistant diabetes mellitus (HP:0000831)2.37085421
58Abnormality of the hepatic vasculature (HP:0006707)2.36666211
59Renal dysplasia (HP:0000110)2.36074277
60Tubulointerstitial abnormality (HP:0001969)2.34837826
61Polydipsia (HP:0001959)2.33108506
62Abnormal drinking behavior (HP:0030082)2.33108506
63Abnormality of renal excretion (HP:0011036)2.26569465
64Ventricular tachycardia (HP:0004756)2.25785039
65Hypophosphatemic rickets (HP:0004912)2.13834841
66Flattened epiphyses (HP:0003071)2.13628260
67Progressive hearing impairment (HP:0001730)2.10822102
68Bronchiectasis (HP:0002110)2.09684200
69Polyuria (HP:0000103)2.09444814
70Epiphyseal dysplasia (HP:0002656)2.09433862
71Widely patent fontanelles and sutures (HP:0004492)2.08822755
72Osteomalacia (HP:0002749)2.07396587
73Recurrent pneumonia (HP:0006532)2.06846841
74Abnormality of the renal medulla (HP:0100957)2.04016847
75Chronic bronchitis (HP:0004469)2.00766026
76Abnormality of the pubic bones (HP:0003172)1.95862131
77Hyponatremia (HP:0002902)1.93793654
78Tetany (HP:0001281)1.92314742
79Intellectual disability, moderate (HP:0002342)1.91522609
80Abnormality of the parathyroid morphology (HP:0011766)1.91456366
81Renal Fanconi syndrome (HP:0001994)1.87632649
82Focal segmental glomerulosclerosis (HP:0000097)1.83211495
83Recurrent corneal erosions (HP:0000495)1.82027478
84Hyperuricemia (HP:0002149)1.81993698
85Increased purine levels (HP:0004368)1.81993698
86Abnormal ventriculo-arterial connection (HP:0011563)1.79496428
87Transposition of the great arteries (HP:0001669)1.79496428
88Abnormal connection of the cardiac segments (HP:0011545)1.79496428
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.78316070
90Decreased central vision (HP:0007663)1.77679433
91Bradycardia (HP:0001662)1.76219471
92Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73678284
93Absent epiphyses (HP:0010577)1.73678284
94Spastic paraparesis (HP:0002313)1.71993678
95Photophobia (HP:0000613)1.71333064
96Bowel incontinence (HP:0002607)1.67567365
97Congenital sensorineural hearing impairment (HP:0008527)1.67057128
98Subcapsular cataract (HP:0000523)1.66263221
99Hyperthyroidism (HP:0000836)1.65274924
100Gingivitis (HP:0000230)1.64964638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.76402656
2TESK15.87033560
3DDR24.44238792
4INSRR3.84078293
5BRD43.47195533
6MAP4K23.38222716
7PLK23.15078638
8STK383.10825546
9PNCK2.64888079
10MAPK152.35564516
11CAMK1G2.30016774
12PRKD32.11752245
13STK38L1.95875897
14PIK3CG1.85455549
15PDPK11.70018318
16CDK121.67819902
17WNK11.65394383
18PDK11.63531992
19MST1R1.61219084
20PINK11.46728247
21DYRK1B1.26013601
22PTK2B1.23213215
23CDK71.21436360
24NEK61.20479147
25KSR21.08619411
26TYRO30.92728779
27CAMK1D0.92248450
28MAP3K110.87341882
29SIK20.85018811
30AKT30.80728660
31MAP3K90.78646331
32RPS6KA20.77154066
33PRKG20.76793139
34LATS20.74134267
35MAP3K20.65079051
36PRKG10.63170087
37MAP3K10.62285962
38BRAF0.61870193
39RPS6KA10.61231486
40SGK2230.60792244
41SGK4940.60792244
42UHMK10.58420558
43LATS10.58010558
44PRKAA20.57477106
45CDK30.56868292
46MARK30.53281633
47MAP2K20.51948816
48CAMK10.51064211
49RPS6KC10.49537013
50RPS6KL10.49537013
51RIPK40.49095661
52MAP3K80.44699871
53MAPK10.44367445
54WNK40.44032655
55TESK20.43216994
56RPS6KA60.42805659
57ROCK10.42254601
58GSK3B0.41562872
59BLK0.41198083
60CDK20.41048557
61ARAF0.38123938
62MAPK110.37727490
63CAMK40.36925099
64MTOR0.36851547
65JAK30.35502789
66CDK40.34924590
67CDK10.34769503
68MAPK80.32668147
69MARK20.31556264
70STK390.31451282
71GRK60.29812057
72SGK10.29066796
73SGK20.28502194
74NEK20.28426989
75KIT0.28124205
76PRKCZ0.25551075
77DYRK30.24932907
78BMPR1B0.24612421
79CHEK10.22330201
80PRKCG0.21922233
81MAPK140.21022981
82TIE10.20910183
83MAPK100.20773136
84PRKCB0.20084332
85MUSK0.19139422
86MAP3K130.16854378
87AKT10.16799989
88TNK20.16699091
89NTRK30.15854634
90SGK30.14012628
91IKBKB0.09927819
92OXSR10.09577407
93PRKCQ0.09488988
94PRKCH0.07745968
95TNIK0.07613270
96FRK0.06641842
97MAP3K70.05894655
98PKN10.05786917
99PRKACB0.05678340
100MARK10.05423303

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.79085076
2Fatty acid biosynthesis_Homo sapiens_hsa000616.12501179
3Olfactory transduction_Homo sapiens_hsa047403.83007666
4Butanoate metabolism_Homo sapiens_hsa006502.33651695
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.12936258
6Dorso-ventral axis formation_Homo sapiens_hsa043202.00201386
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94796695
8Allograft rejection_Homo sapiens_hsa053301.89703270
9Type I diabetes mellitus_Homo sapiens_hsa049401.86467727
10Autoimmune thyroid disease_Homo sapiens_hsa053201.84210100
11Graft-versus-host disease_Homo sapiens_hsa053321.77633160
12Antigen processing and presentation_Homo sapiens_hsa046121.68642850
13Taste transduction_Homo sapiens_hsa047421.64282679
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63558052
15Type II diabetes mellitus_Homo sapiens_hsa049301.63268604
16Phenylalanine metabolism_Homo sapiens_hsa003601.62178984
17Fatty acid degradation_Homo sapiens_hsa000711.50015813
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48052028
19RNA transport_Homo sapiens_hsa030131.39514904
20Fatty acid metabolism_Homo sapiens_hsa012121.29915213
21Viral myocarditis_Homo sapiens_hsa054161.29164902
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26433856
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.26014968
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21705332
25Endocytosis_Homo sapiens_hsa041441.15423571
26Influenza A_Homo sapiens_hsa051641.12242045
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10508516
28Inositol phosphate metabolism_Homo sapiens_hsa005621.02031523
29Salivary secretion_Homo sapiens_hsa049700.95607546
30Protein digestion and absorption_Homo sapiens_hsa049740.94559186
31Arginine biosynthesis_Homo sapiens_hsa002200.94337028
32Acute myeloid leukemia_Homo sapiens_hsa052210.94213099
33Arginine and proline metabolism_Homo sapiens_hsa003300.92499333
34Hedgehog signaling pathway_Homo sapiens_hsa043400.90677286
35PPAR signaling pathway_Homo sapiens_hsa033200.90636699
36Synaptic vesicle cycle_Homo sapiens_hsa047210.87305587
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84673097
38Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82712514
39Calcium signaling pathway_Homo sapiens_hsa040200.81357043
40cAMP signaling pathway_Homo sapiens_hsa040240.79175836
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78250686
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78195260
43B cell receptor signaling pathway_Homo sapiens_hsa046620.72877139
44Estrogen signaling pathway_Homo sapiens_hsa049150.71542458
45Morphine addiction_Homo sapiens_hsa050320.70885435
46ABC transporters_Homo sapiens_hsa020100.70787209
47Phototransduction_Homo sapiens_hsa047440.70652898
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70610856
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70353330
50Renin-angiotensin system_Homo sapiens_hsa046140.68991877
51VEGF signaling pathway_Homo sapiens_hsa043700.67349031
52Oocyte meiosis_Homo sapiens_hsa041140.64988484
53Renin secretion_Homo sapiens_hsa049240.59572186
54Fat digestion and absorption_Homo sapiens_hsa049750.58657025
55Tyrosine metabolism_Homo sapiens_hsa003500.58005899
56MAPK signaling pathway_Homo sapiens_hsa040100.57173894
57Circadian entrainment_Homo sapiens_hsa047130.56443440
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56244097
59Herpes simplex infection_Homo sapiens_hsa051680.55740136
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55341838
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.53685082
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53097359
63Glycerolipid metabolism_Homo sapiens_hsa005610.52745638
64Gastric acid secretion_Homo sapiens_hsa049710.47429620
65Glutamatergic synapse_Homo sapiens_hsa047240.47408001
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.46674520
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46463562
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46298392
69Prolactin signaling pathway_Homo sapiens_hsa049170.46292953
70Long-term potentiation_Homo sapiens_hsa047200.44420505
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.42752852
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.41793318
73Nicotine addiction_Homo sapiens_hsa050330.41727618
74Cardiac muscle contraction_Homo sapiens_hsa042600.41613721
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40716399
76mRNA surveillance pathway_Homo sapiens_hsa030150.40378148
77Retinol metabolism_Homo sapiens_hsa008300.39707910
78Viral carcinogenesis_Homo sapiens_hsa052030.39538998
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38965994
80Pancreatic secretion_Homo sapiens_hsa049720.36250118
81Gap junction_Homo sapiens_hsa045400.36176092
82Toxoplasmosis_Homo sapiens_hsa051450.35913698
83Cholinergic synapse_Homo sapiens_hsa047250.35316733
84Nitrogen metabolism_Homo sapiens_hsa009100.35299882
85Bile secretion_Homo sapiens_hsa049760.34603416
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33740809
87Purine metabolism_Homo sapiens_hsa002300.33257107
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31481299
89Oxytocin signaling pathway_Homo sapiens_hsa049210.31218187
90Insulin secretion_Homo sapiens_hsa049110.30723847
91Basal transcription factors_Homo sapiens_hsa030220.30587531
92Legionellosis_Homo sapiens_hsa051340.30001502
93T cell receptor signaling pathway_Homo sapiens_hsa046600.28851366
94Prostate cancer_Homo sapiens_hsa052150.28430308
95Serotonergic synapse_Homo sapiens_hsa047260.28038197
96Phagosome_Homo sapiens_hsa041450.27779552
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26113948
98Chemokine signaling pathway_Homo sapiens_hsa040620.24782816
99Non-small cell lung cancer_Homo sapiens_hsa052230.24446361
100Osteoclast differentiation_Homo sapiens_hsa043800.23788770

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