DROSHA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* pre-miRNA processing (GO:0031054)4.50497390
2nuclear pore organization (GO:0006999)4.06725287
3DNA topological change (GO:0006265)3.97606076
4regulation of gene silencing by RNA (GO:0060966)3.91649633
5regulation of posttranscriptional gene silencing (GO:0060147)3.91649633
6regulation of gene silencing by miRNA (GO:0060964)3.91649633
7nuclear pore complex assembly (GO:0051292)3.84855944
8DNA replication checkpoint (GO:0000076)3.79312258
9peptidyl-arginine omega-N-methylation (GO:0035247)3.76301950
10DNA unwinding involved in DNA replication (GO:0006268)3.71326244
11DNA strand elongation involved in DNA replication (GO:0006271)3.69757592
12heterochromatin organization (GO:0070828)3.66407476
13paraxial mesoderm development (GO:0048339)3.60149016
14DNA strand elongation (GO:0022616)3.56301336
15peptidyl-arginine methylation (GO:0018216)3.48560148
16peptidyl-arginine N-methylation (GO:0035246)3.48560148
17histone H4-K12 acetylation (GO:0043983)3.45136317
18mitotic sister chromatid cohesion (GO:0007064)3.43349723
19kinetochore organization (GO:0051383)3.36381030
20histone arginine methylation (GO:0034969)3.33643053
21mitotic sister chromatid segregation (GO:0000070)3.19954166
22formation of translation preinitiation complex (GO:0001731)3.17701784
23telomere maintenance via semi-conservative replication (GO:0032201)3.14997700
24sister chromatid segregation (GO:0000819)3.14132921
25regulation of translational fidelity (GO:0006450)3.13892357
26protein localization to kinetochore (GO:0034501)3.12742446
27negative regulation of histone methylation (GO:0031061)3.12189675
28chromosome condensation (GO:0030261)3.11990453
29regulation of translational termination (GO:0006449)3.10007057
30regulation of DNA endoreduplication (GO:0032875)3.09619697
31establishment of integrated proviral latency (GO:0075713)3.07117853
32regulation of sister chromatid cohesion (GO:0007063)3.06651449
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05707646
34DNA replication-dependent nucleosome assembly (GO:0006335)3.04311930
35DNA replication-dependent nucleosome organization (GO:0034723)3.04311930
36mitotic nuclear envelope disassembly (GO:0007077)3.04207060
37spliceosomal tri-snRNP complex assembly (GO:0000244)3.01388536
38DNA conformation change (GO:0071103)2.99173806
39nuclear envelope disassembly (GO:0051081)2.97216932
40membrane disassembly (GO:0030397)2.97216932
41regulation of centrosome cycle (GO:0046605)2.97072777
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96311053
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96311053
44positive regulation of mitotic sister chromatid separation (GO:1901970)2.96311053
45ATP-dependent chromatin remodeling (GO:0043044)2.91622050
46positive regulation of chromosome segregation (GO:0051984)2.90649847
47protein complex localization (GO:0031503)2.87436123
48positive regulation of synapse maturation (GO:0090129)2.86614400
49regulation of RNA export from nucleus (GO:0046831)2.82839480
50protein export from nucleus (GO:0006611)2.82374596
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81943909
52DNA synthesis involved in DNA repair (GO:0000731)2.81131764
53protein localization to chromosome (GO:0034502)2.80772471
54DNA packaging (GO:0006323)2.80256398
55chromatin remodeling at centromere (GO:0031055)2.80044062
56CENP-A containing nucleosome assembly (GO:0034080)2.79980081
57histone H2A monoubiquitination (GO:0035518)2.78138181
58cell migration in hindbrain (GO:0021535)2.76485771
59establishment of apical/basal cell polarity (GO:0035089)2.76088653
60planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75959792
61mitotic recombination (GO:0006312)2.75883779
62sister chromatid cohesion (GO:0007062)2.75638619
63DNA duplex unwinding (GO:0032508)2.75523005
64glucocorticoid receptor signaling pathway (GO:0042921)2.74396245
65regulation of centrosome duplication (GO:0010824)2.74390093
66DNA geometric change (GO:0032392)2.73003188
67chromatin assembly or disassembly (GO:0006333)2.72940520
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72770178
69chromatin assembly (GO:0031497)2.71568876
70DNA replication-independent nucleosome assembly (GO:0006336)2.71276242
71DNA replication-independent nucleosome organization (GO:0034724)2.71276242
72telomere maintenance via recombination (GO:0000722)2.70421598
73NLS-bearing protein import into nucleus (GO:0006607)2.70270106
74regulation of histone H3-K9 methylation (GO:0051570)2.69266370
75regulation of histone H3-K4 methylation (GO:0051569)2.68595944
76layer formation in cerebral cortex (GO:0021819)2.68519640
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68264423
78double-strand break repair via nonhomologous end joining (GO:0006303)2.66504419
79non-recombinational repair (GO:0000726)2.66504419
80chromosome segregation (GO:0007059)2.66108442
81mitotic chromosome condensation (GO:0007076)2.65208019
82histone H4-K5 acetylation (GO:0043981)2.65004899
83histone H4-K8 acetylation (GO:0043982)2.65004899
84histone H2B ubiquitination (GO:0033523)2.64899546
85kinetochore assembly (GO:0051382)2.64607044
86positive regulation of cell cycle checkpoint (GO:1901978)2.64514996
87peptidyl-lysine dimethylation (GO:0018027)2.64456008
88negative regulation of mRNA processing (GO:0050686)2.61185290
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61158557
90pore complex assembly (GO:0046931)2.59305172
91establishment or maintenance of monopolar cell polarity (GO:0061339)2.58024044
92establishment of monopolar cell polarity (GO:0061162)2.58024044
93cellular protein complex localization (GO:0034629)2.57728410
94regulation of DNA damage checkpoint (GO:2000001)2.57157394
95IMP biosynthetic process (GO:0006188)2.56173104
96convergent extension (GO:0060026)2.55148512
97gene silencing by RNA (GO:0031047)2.54860300
98positive regulation of RNA splicing (GO:0033120)2.54796679
99regulation of DNA-dependent DNA replication (GO:0090329)2.53854266
100protein-DNA complex disassembly (GO:0032986)2.52640477
101nucleosome disassembly (GO:0006337)2.52640477
102DNA replication initiation (GO:0006270)2.51672909
103negative regulation of RNA splicing (GO:0033119)2.51120901
104protein localization to chromosome, centromeric region (GO:0071459)2.50419377
105spindle organization (GO:0007051)2.50186991
106mitotic metaphase plate congression (GO:0007080)2.49803109
107regulation of centriole replication (GO:0046599)2.49517686
108regulation of NFAT protein import into nucleus (GO:0051532)2.49033169
109RNA stabilization (GO:0043489)2.48886484
110mRNA stabilization (GO:0048255)2.48886484
111positive regulation of DNA-dependent DNA replication (GO:2000105)2.48448635
112polarized epithelial cell differentiation (GO:0030859)2.48068243
113negative regulation of DNA repair (GO:0045738)2.47569193
114RNA transport (GO:0050658)2.47191280
115establishment of RNA localization (GO:0051236)2.47191280
116nucleic acid transport (GO:0050657)2.47191280
117regulation of histone methylation (GO:0031060)2.46994014
118folic acid-containing compound biosynthetic process (GO:0009396)2.46744975
119dosage compensation (GO:0007549)2.46077253
120regulation of chromosome segregation (GO:0051983)2.45426434
121negative regulation of mRNA metabolic process (GO:1903312)2.45375239
122mitotic spindle organization (GO:0007052)2.44993441
123intracellular estrogen receptor signaling pathway (GO:0030520)2.44605149
124gene silencing (GO:0016458)2.44394308
125regulation of hippo signaling (GO:0035330)2.44248867
126nucleobase biosynthetic process (GO:0046112)2.44172202
127positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.43441521
128regulation of spindle organization (GO:0090224)2.42556716
129L-serine metabolic process (GO:0006563)2.41725188
130spindle checkpoint (GO:0031577)2.41554237
131regulation of short-term neuronal synaptic plasticity (GO:0048172)2.40781469
132establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.39195958
133negative regulation of chromosome segregation (GO:0051985)2.37826286
134mRNA transport (GO:0051028)2.35880269
135hippo signaling (GO:0035329)2.35603334
136mRNA splice site selection (GO:0006376)2.35384303
137regulation of meiosis I (GO:0060631)2.34957239
138establishment of nucleus localization (GO:0040023)2.34489455
139anterior/posterior axis specification, embryo (GO:0008595)2.33126119
140metaphase plate congression (GO:0051310)2.32495497
141regulation of nucleobase-containing compound transport (GO:0032239)2.32359432
142negative regulation of histone modification (GO:0031057)2.32328332
143regulation of mitotic sister chromatid separation (GO:0010965)2.32262279
144regulation of mitotic sister chromatid segregation (GO:0033047)2.32262279
145regulation of sister chromatid segregation (GO:0033045)2.32262279
146nuclear envelope organization (GO:0006998)2.31002148
147regulation of mitotic spindle organization (GO:0060236)2.30812250
148mitotic spindle assembly checkpoint (GO:0007094)2.30687378
149positive regulation of SMAD protein import into nucleus (GO:0060391)2.29811453
150spindle assembly checkpoint (GO:0071173)2.29331225
151mitotic G1 DNA damage checkpoint (GO:0031571)2.28707344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.84993810
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60921417
3E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89932484
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.88819025
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.67567606
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.63073007
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45109007
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.39643795
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.32379794
10SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.29144198
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28314275
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.26731948
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.26466660
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.26466660
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.26466660
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23724215
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21096957
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.05871733
19ZFP281_27345836_Chip-Seq_ESCs_Mouse1.98180539
20MYC_22102868_ChIP-Seq_BL_Human1.95799734
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95743895
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.94326774
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.92683116
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84470101
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81460280
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78928206
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76194426
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75485362
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74223365
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73625427
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70802016
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69946232
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69487514
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68645316
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.67441845
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64813109
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.63105822
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61949110
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58784082
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57382786
41NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.57284063
42EZH2_22144423_ChIP-Seq_EOC_Human1.53654065
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50977095
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.49553336
45XRN2_22483619_ChIP-Seq_HELA_Human1.48738048
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47594444
47CIITA_25753668_ChIP-Seq_RAJI_Human1.46971103
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46862555
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.46651592
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46304521
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46065630
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44545895
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43114894
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40924206
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40706208
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.40230331
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39590120
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39481609
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39184114
60AR_21909140_ChIP-Seq_LNCAP_Human1.37914585
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37309298
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36257104
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34701680
64* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27508031
65CHD1_26751641_Chip-Seq_LNCaP_Human1.26771918
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.26293494
67DCP1A_22483619_ChIP-Seq_HELA_Human1.25457896
68KDM2B_26808549_Chip-Seq_DND41_Human1.25143959
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24428287
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23829913
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23305903
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23266422
73POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22854542
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21876021
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20179142
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19147313
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18891340
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18073914
79TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16781862
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15722378
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15430456
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15046927
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14651185
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14544163
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13339670
86KDM2B_26808549_Chip-Seq_K562_Human1.12391498
87GABP_19822575_ChIP-Seq_HepG2_Human1.12334422
88KDM5A_27292631_Chip-Seq_BREAST_Human1.11404965
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10824107
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09732210
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.09512839
92EST1_17652178_ChIP-ChIP_JURKAT_Human1.09072761
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06834097
94CLOCK_20551151_ChIP-Seq_293T_Human1.06274746
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06222044
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06117505
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05924102
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04119532
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03257002
100PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02069487
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01789101
102SOX17_20123909_ChIP-Seq_XEN_Mouse1.01744345
103TTF2_22483619_ChIP-Seq_HELA_Human1.01133570
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00940081
105SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00918572
106TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99720934
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98885535
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.96649765
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96503606
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95722584
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95618003
112HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94187861
113ELK1_19687146_ChIP-ChIP_HELA_Human0.93561640
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93378279
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93179848
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91594419
117TCF7_22412390_ChIP-Seq_EML_Mouse0.91371865
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91315119
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.90680361
120ZNF263_19887448_ChIP-Seq_K562_Human0.90645507
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90019285
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89981678
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.89951320
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89562458
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88675413
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88096360
127TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87889598
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.81691054
129NANOG_16153702_ChIP-ChIP_HESCs_Human0.75519333
130FOXP3_21729870_ChIP-Seq_TREG_Human0.73347554
131SOX9_26525672_Chip-Seq_HEART_Mouse0.71561091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting2.85701330
2MP0004859_abnormal_synaptic_plasticity2.57636242
3MP0003111_abnormal_nucleus_morphology2.47630959
4MP0004957_abnormal_blastocyst_morpholog2.32596610
5MP0008877_abnormal_DNA_methylation2.30626232
6MP0003121_genomic_imprinting2.27000898
7MP0010094_abnormal_chromosome_stability2.25572501
8MP0002653_abnormal_ependyma_morphology2.16392242
9MP0003119_abnormal_digestive_system2.01245222
10MP0010030_abnormal_orbit_morphology2.00396816
11MP0003077_abnormal_cell_cycle1.97806040
12MP0001730_embryonic_growth_arrest1.92168026
13MP0003122_maternal_imprinting1.90923254
14MP0002084_abnormal_developmental_patter1.89282636
15MP0004233_abnormal_muscle_weight1.88730798
16MP0000537_abnormal_urethra_morphology1.88696360
17MP0005623_abnormal_meninges_morphology1.87992633
18MP0003283_abnormal_digestive_organ1.83813485
19MP0003890_abnormal_embryonic-extraembry1.79113485
20MP0002877_abnormal_melanocyte_morpholog1.77043533
21MP0010352_gastrointestinal_tract_polyps1.73548074
22MP0002085_abnormal_embryonic_tissue1.72288497
23MP0005076_abnormal_cell_differentiation1.72252207
24MP0003693_abnormal_embryo_hatching1.70889783
25MP0003787_abnormal_imprinting1.64396767
26MP0004197_abnormal_fetal_growth/weight/1.61759508
27MP0001672_abnormal_embryogenesis/_devel1.59443793
28MP0005380_embryogenesis_phenotype1.59443793
29MP0000350_abnormal_cell_proliferation1.59208494
30MP0001697_abnormal_embryo_size1.57442729
31MP0008057_abnormal_DNA_replication1.56954404
32MP0003705_abnormal_hypodermis_morpholog1.51790778
33MP0001346_abnormal_lacrimal_gland1.51156098
34MP0004185_abnormal_adipocyte_glucose1.49211800
35MP0003861_abnormal_nervous_system1.48138675
36MP0004133_heterotaxia1.43957867
37MP0003984_embryonic_growth_retardation1.43599302
38MP0002396_abnormal_hematopoietic_system1.43024885
39MP0002088_abnormal_embryonic_growth/wei1.41321417
40MP0008932_abnormal_embryonic_tissue1.38781960
41MP0003635_abnormal_synaptic_transmissio1.38124824
42MP0002086_abnormal_extraembryonic_tissu1.34910902
43MP0000566_synostosis1.30624312
44MP0004858_abnormal_nervous_system1.30233569
45MP0004270_analgesia1.29229662
46MP0001286_abnormal_eye_development1.27346573
47MP0002080_prenatal_lethality1.25270253
48MP0003937_abnormal_limbs/digits/tail_de1.24986442
49MP0000428_abnormal_craniofacial_morphol1.24715651
50MP0008058_abnormal_DNA_repair1.24389929
51MP0001849_ear_inflammation1.24013184
52MP0002092_abnormal_eye_morphology1.23085858
53MP0000778_abnormal_nervous_system1.21283640
54MP0001293_anophthalmia1.21122721
55MP0005409_darkened_coat_color1.18135445
56MP0005499_abnormal_olfactory_system1.18079019
57MP0005394_taste/olfaction_phenotype1.18079019
58MP0003385_abnormal_body_wall1.17564332
59MP0000534_abnormal_ureter_morphology1.16711338
60MP0000579_abnormal_nail_morphology1.16509898
61MP0001299_abnormal_eye_distance/1.16149109
62MP0002063_abnormal_learning/memory/cond1.16116302
63MP0005187_abnormal_penis_morphology1.15967390
64MP0003567_abnormal_fetal_cardiomyocyte1.15297295
65MP0003935_abnormal_craniofacial_develop1.14653875
66MP0006292_abnormal_olfactory_placode1.12008527
67MP0002249_abnormal_larynx_morphology1.09536484
68MP0009703_decreased_birth_body1.08665995
69MP0009053_abnormal_anal_canal1.08252664
70MP0002152_abnormal_brain_morphology1.06531944
71MP0010307_abnormal_tumor_latency1.05305568
72MP0003755_abnormal_palate_morphology1.02902666
73MP0002938_white_spotting1.02870469
74MP0004145_abnormal_muscle_electrophysio1.02258545
75MP0000049_abnormal_middle_ear1.01501857
76MP0009672_abnormal_birth_weight1.01226357
77MP0003115_abnormal_respiratory_system1.00206721
78MP0003941_abnormal_skin_development0.98919438
79MP0002009_preneoplasia0.98650377
80MP0004811_abnormal_neuron_physiology0.97556017
81MP0001188_hyperpigmentation0.97503507
82MP0008007_abnormal_cellular_replicative0.97300575
83MP0000762_abnormal_tongue_morphology0.97088454
84MP0000751_myopathy0.96838807
85MP0010234_abnormal_vibrissa_follicle0.96293506
86MP0002697_abnormal_eye_size0.95989773
87MP0002184_abnormal_innervation0.94841726
88MP0009697_abnormal_copulation0.94206914
89MP0000313_abnormal_cell_death0.93260486
90MP0002116_abnormal_craniofacial_bone0.92935849
91MP0000955_abnormal_spinal_cord0.92674868
92MP0005257_abnormal_intraocular_pressure0.92471732
93MP0000569_abnormal_digit_pigmentation0.92164571
94MP0005171_absent_coat_pigmentation0.92041392
95MP0000733_abnormal_muscle_development0.91953257
96MP0003315_abnormal_perineum_morphology0.91039237
97MP0002210_abnormal_sex_determination0.90809863
98MP0003942_abnormal_urinary_system0.89999780
99MP0001348_abnormal_lacrimal_gland0.89869717
100MP0008789_abnormal_olfactory_epithelium0.89291696
101MP0003718_maternal_effect0.89115977
102MP0002925_abnormal_cardiovascular_devel0.88929962
103MP0002081_perinatal_lethality0.88898466
104MP0002114_abnormal_axial_skeleton0.88862011
105MP0003880_abnormal_central_pattern0.86318737
106MP0000432_abnormal_head_morphology0.86016416
107MP0002932_abnormal_joint_morphology0.84480422
108MP0003136_yellow_coat_color0.84473076
109MP0008770_decreased_survivor_rate0.82743837
110MP0006072_abnormal_retinal_apoptosis0.82258502
111MP0002234_abnormal_pharynx_morphology0.82002340
112MP0001145_abnormal_male_reproductive0.80439633
113MP0001661_extended_life_span0.80107700
114MP0002111_abnormal_tail_morphology0.79636814
115MP0002233_abnormal_nose_morphology0.79477502
116MP0004272_abnormal_basement_membrane0.79208113
117MP0000631_abnormal_neuroendocrine_gland0.76760357
118MP0004084_abnormal_cardiac_muscle0.76383641
119MP0005621_abnormal_cell_physiology0.76141216
120MP0003786_premature_aging0.75360852
121MP0002089_abnormal_postnatal_growth/wei0.75293606
122MP0009250_abnormal_appendicular_skeleto0.75051464
123MP0008961_abnormal_basal_metabolism0.75019484
124MP0002572_abnormal_emotion/affect_behav0.74629170
125MP0002751_abnormal_autonomic_nervous0.74556886
126MP0002269_muscular_atrophy0.74532925
127MP0002882_abnormal_neuron_morphology0.74292225
128MP0010630_abnormal_cardiac_muscle0.73639389
129MP0005384_cellular_phenotype0.73430866
130MP0004808_abnormal_hematopoietic_stem0.72587094
131MP0003938_abnormal_ear_development0.71961372
132MP0003950_abnormal_plasma_membrane0.71697389
133MP0001340_abnormal_eyelid_morphology0.70845053

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.96160871
2Ependymoma (HP:0002888)3.95180123
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89162482
4Abnormality of the astrocytes (HP:0100707)3.64242882
5Astrocytoma (HP:0009592)3.64242882
6Abnormality of the labia minora (HP:0012880)3.15122120
7Abnormality of the lower motor neuron (HP:0002366)3.11636890
8Birth length less than 3rd percentile (HP:0003561)2.92146105
9Glioma (HP:0009733)2.85065548
10Cortical dysplasia (HP:0002539)2.79258306
11Medulloblastoma (HP:0002885)2.73158257
12Renal duplication (HP:0000075)2.64043707
13Rib fusion (HP:0000902)2.58193481
14Increased nuchal translucency (HP:0010880)2.52490105
15Colon cancer (HP:0003003)2.51237364
16Hyperacusis (HP:0010780)2.48966249
17Neoplasm of the oral cavity (HP:0100649)2.45192159
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41089507
19Short 4th metacarpal (HP:0010044)2.41089507
20Volvulus (HP:0002580)2.34557088
21Neoplasm of striated muscle (HP:0009728)2.27967801
22Pointed chin (HP:0000307)2.25527210
23Abnormality of cochlea (HP:0000375)2.18215074
24Shawl scrotum (HP:0000049)2.18033367
25Reticulocytopenia (HP:0001896)2.17423255
26Insomnia (HP:0100785)2.17081144
27Aplasia/Hypoplasia of the sternum (HP:0006714)2.13329785
28Abnormality of the calcaneus (HP:0008364)2.12608486
29Missing ribs (HP:0000921)2.11463774
30Selective tooth agenesis (HP:0001592)2.11455999
31Rhabdomyosarcoma (HP:0002859)2.09762282
32Ectopic kidney (HP:0000086)2.06965894
33Nephroblastoma (Wilms tumor) (HP:0002667)2.06673983
34Deep philtrum (HP:0002002)2.04638542
35Shoulder girdle muscle weakness (HP:0003547)2.03874562
36Annular pancreas (HP:0001734)2.02878914
37Trigonocephaly (HP:0000243)2.01896953
38Duplication of thumb phalanx (HP:0009942)1.98537637
39Proximal placement of thumb (HP:0009623)1.98359492
40Deviation of the thumb (HP:0009603)1.97992647
41Elfin facies (HP:0004428)1.97778558
42High anterior hairline (HP:0009890)1.96846808
43Abnormal number of incisors (HP:0011064)1.95310352
44Abnormality of chromosome stability (HP:0003220)1.95289676
45Progressive muscle weakness (HP:0003323)1.92552658
46Abnormality of the carotid arteries (HP:0005344)1.91821449
47Embryonal renal neoplasm (HP:0011794)1.91447627
48Aplasia/Hypoplasia of the uvula (HP:0010293)1.90944893
49Supernumerary ribs (HP:0005815)1.89868340
50Renovascular hypertension (HP:0100817)1.89833212
51Amyotrophic lateral sclerosis (HP:0007354)1.89628805
52Abnormality of the phalanges of the hallux (HP:0010057)1.89460790
53Sacral dimple (HP:0000960)1.89038137
54Calcaneovalgus deformity (HP:0001848)1.89015477
55Obsessive-compulsive behavior (HP:0000722)1.88462839
56Shallow orbits (HP:0000586)1.88424281
57Meckel diverticulum (HP:0002245)1.88393230
58Patellar aplasia (HP:0006443)1.87915584
59Abdominal situs inversus (HP:0003363)1.87284645
60Abnormality of abdominal situs (HP:0011620)1.87284645
61Heterotopia (HP:0002282)1.87001242
62Facial hemangioma (HP:0000329)1.86829607
63Asymmetry of the thorax (HP:0001555)1.85418483
64Bowel diverticulosis (HP:0005222)1.85249070
65Abnormality of the 4th metacarpal (HP:0010012)1.84576325
66Skull defect (HP:0001362)1.84546276
67Abnormality of the distal phalanx of the thumb (HP:0009617)1.84472733
68Urethral obstruction (HP:0000796)1.84349163
69Neoplasm of the heart (HP:0100544)1.84211084
70Overlapping toe (HP:0001845)1.84028872
71Dysmetric saccades (HP:0000641)1.83032622
72Abnormality of the diencephalon (HP:0010662)1.82446060
73Pelvic girdle muscle weakness (HP:0003749)1.81893742
74Supernumerary spleens (HP:0009799)1.81816413
75Aplasia/hypoplasia of the humerus (HP:0006507)1.80420074
76Broad thumb (HP:0011304)1.80252552
77Angiofibromas (HP:0010615)1.79318263
78Adenoma sebaceum (HP:0009720)1.79318263
79Overriding aorta (HP:0002623)1.79043858
80Short humerus (HP:0005792)1.78894667
81Sandal gap (HP:0001852)1.78877818
82Abnormality of the ileum (HP:0001549)1.77201076
83Facial cleft (HP:0002006)1.77065711
84Aplasia/Hypoplasia of the patella (HP:0006498)1.76518016
85Broad palm (HP:0001169)1.75721752
86Hepatoblastoma (HP:0002884)1.75651027
87Limited elbow extension (HP:0001377)1.75224846
88Relative macrocephaly (HP:0004482)1.74964400
89Benign neoplasm of the central nervous system (HP:0100835)1.72759549
90Fibroma (HP:0010614)1.71875520
91Gastrointestinal carcinoma (HP:0002672)1.71155805
92Malignant gastrointestinal tract tumors (HP:0006749)1.71155805
93Hypopigmentation of the fundus (HP:0007894)1.71152882
94Supernumerary bones of the axial skeleton (HP:0009144)1.70163580
95Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70128918
96Abnormality of the preputium (HP:0100587)1.69201733
97Patellar dislocation (HP:0002999)1.68819060
98Smooth philtrum (HP:0000319)1.68339081
99Basal cell carcinoma (HP:0002671)1.68124627
100Attention deficit hyperactivity disorder (HP:0007018)1.67052196
101Abnormality of chromosome segregation (HP:0002916)1.66856513
102Spina bifida occulta (HP:0003298)1.66799928
103Morphological abnormality of the inner ear (HP:0011390)1.65936041
104Megalocornea (HP:0000485)1.65696608
105Absent epiphyses (HP:0010577)1.65470765
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65470765
107Myokymia (HP:0002411)1.64597517
108Abnormality of the fingertips (HP:0001211)1.64341754
109Papillary thyroid carcinoma (HP:0002895)1.64247402
110Fibrous tissue neoplasm (HP:0012316)1.64093217
111Pseudobulbar signs (HP:0002200)1.63862645
112Malignant neoplasm of the central nervous system (HP:0100836)1.63794243
113Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63723876
114Short 1st metacarpal (HP:0010034)1.63723876
115Focal seizures (HP:0007359)1.62434135
116Diastasis recti (HP:0001540)1.62314179
117Cafe-au-lait spot (HP:0000957)1.61251772
118Partial agenesis of the corpus callosum (HP:0001338)1.60942132
119Ankyloglossia (HP:0010296)1.60767819
120Choanal atresia (HP:0000453)1.60764854
121Ulnar bowing (HP:0003031)1.60591939
122Disproportionate tall stature (HP:0001519)1.59680684
123Atresia of the external auditory canal (HP:0000413)1.59344307
124Esophageal atresia (HP:0002032)1.58625700
125Abnormality of the hip-girdle musculature (HP:0001445)1.57872160
126Abnormality of the musculature of the pelvis (HP:0001469)1.57872160
127Deformed tarsal bones (HP:0008119)1.57652454
128Oligodactyly (HP:0012165)1.57304788
129Long eyelashes (HP:0000527)1.57001190
130Resting tremor (HP:0002322)1.56425657
131Macroorchidism (HP:0000053)1.55806275
132Flat cornea (HP:0007720)1.55573204
133Short phalanx of the thumb (HP:0009660)1.55406994
134Cutaneous syndactyly (HP:0012725)1.54873967
135Termporal pattern (HP:0011008)1.54796123
136Insidious onset (HP:0003587)1.54796123
137Absent radius (HP:0003974)1.54463096
138Long palpebral fissure (HP:0000637)1.54171340
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.53965943
140Anophthalmia (HP:0000528)1.53738225
141Broad phalanges of the hand (HP:0009768)1.53652429
142Hemivertebrae (HP:0002937)1.53408365
143Bilateral microphthalmos (HP:0007633)1.52434728
144Vertebral fusion (HP:0002948)1.52374124
145Anal stenosis (HP:0002025)1.52134205
146Absent forearm bone (HP:0003953)1.51631280
147Aplasia involving forearm bones (HP:0009822)1.51631280
148Abnormality of oral frenula (HP:0000190)1.51608521
149Deep palmar crease (HP:0006191)1.50771522
150Broad finger (HP:0001500)1.50040730
151Cutaneous finger syndactyly (HP:0010554)1.49947861
152Abnormality of the aortic arch (HP:0012303)1.48603117
153Chin dimple (HP:0010751)1.47441987
154Septate vagina (HP:0001153)1.46178236
155Narrow face (HP:0000275)1.44646139
156Preauricular skin tag (HP:0000384)1.43079611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.61558380
2CDC73.44420751
3NEK12.56844243
4LATS22.42487946
5EEF2K2.28075505
6MAP3K92.27813222
7BRD41.98867201
8PNCK1.97838739
9ICK1.91327399
10TYRO31.84942712
11ALK1.75550237
12EIF2AK11.74036374
13MARK11.70408540
14SMG11.68397180
15PRKD31.68254751
16NEK21.67728934
17TTK1.64593729
18PKN21.64547433
19BRSK21.61078828
20MAP3K41.56156405
21KSR11.54693860
22TSSK61.54559114
23MAP3K101.52314571
24NTRK31.48125199
25WEE11.43344386
26PBK1.35680773
27MINK11.34228863
28RPS6KB21.30562523
29SCYL21.29119457
30PAK61.25112448
31PDGFRA1.23690776
32PLK31.23419207
33MST1R1.22675735
34PLK41.21964908
35PLK11.21091449
36CHEK21.20407996
37CDK71.20206851
38MTOR1.19042324
39CHEK11.17773219
40BUB11.14912955
41MET1.09303081
42CLK11.09259652
43RIPK11.07970291
44PASK1.03338253
45KSR21.00940025
46CDK21.00358717
47LATS10.99716901
48SRPK10.99515719
49NTRK10.97400237
50TRIB30.95556187
51SIK20.95238395
52STK380.95150348
53ATR0.94383839
54BRSK10.91262000
55UHMK10.90631858
56NTRK20.88641362
57MKNK10.86382566
58EPHA40.86210997
59CSNK1E0.85721636
60CDK40.85415646
61EPHA20.84175383
62CDK80.83366126
63DAPK10.83349946
64ATM0.82714350
65PTK20.80798731
66BMX0.79584036
67CDK10.79272698
68PAK40.77046784
69TTN0.76387246
70DMPK0.76216177
71PLK20.75963508
72FGFR10.75761826
73MKNK20.74697044
74CDC42BPA0.74250473
75DDR20.72911774
76CDK30.72100796
77PHKG20.71290822
78PHKG10.71290822
79TAF10.70861732
80DAPK20.70612086
81AURKA0.70232397
82CDK150.69640312
83CSNK1D0.68513021
84CDK180.68097673
85BRAF0.67696766
86STK30.67521025
87CDK11A0.67171134
88TAOK10.67140623
89MAP3K80.66100826
90CAMK1G0.64387280
91AURKB0.62140162
92STK110.62020418
93MAP2K40.61938403
94EPHB20.61810440
95AKT20.61580740
96CDK140.61106830
97VRK20.60428004
98* GSK3B0.60020307
99PRKDC0.58791650
100MAPK100.58779521
101MAPKAPK50.58496702
102MAPK140.57690333
103MAP3K60.57393991
104LMTK20.56751915
105CDK60.55290351
106PRKCI0.55179252
107PAK20.54262733
108WNK10.51848042
109WNK30.51477829
110RET0.50013591
111PDK20.49513753
112ERBB40.49381434
113CAMK1D0.49351977
114RAF10.47694376
115MELK0.45730100
116TGFBR10.44287373
117TESK20.43982510
118SIK10.43291417
119CAMKK10.43280794
120CSNK2A20.42843242
121MAPK80.42687581
122EIF2AK20.42310917
123CDK50.41444113
124MAPK110.40477961
125FGFR20.39643758
126FGFR40.39573756
127MAPK90.39215964
128CASK0.38961191
129AKT10.38860312
130DYRK30.38811302
131CDK90.38676469
132NME10.36607257
133MAP3K130.36159736
134STK160.34306383
135STK40.33195624

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.31737903
2Non-homologous end-joining_Homo sapiens_hsa034502.29849402
3Spliceosome_Homo sapiens_hsa030402.24618093
4mRNA surveillance pathway_Homo sapiens_hsa030152.22912414
5Mismatch repair_Homo sapiens_hsa034302.06943943
6DNA replication_Homo sapiens_hsa030302.02325458
7Cell cycle_Homo sapiens_hsa041101.96563587
8* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90372240
9Oocyte meiosis_Homo sapiens_hsa041141.90104444
10Hippo signaling pathway_Homo sapiens_hsa043901.59693776
11Long-term potentiation_Homo sapiens_hsa047201.58542775
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53288214
13Basal cell carcinoma_Homo sapiens_hsa052171.52531159
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51730563
15Biosynthesis of amino acids_Homo sapiens_hsa012301.48997936
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48695334
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46859978
18mTOR signaling pathway_Homo sapiens_hsa041501.44760904
19Hedgehog signaling pathway_Homo sapiens_hsa043401.40326552
20Synaptic vesicle cycle_Homo sapiens_hsa047211.36684819
21Nicotine addiction_Homo sapiens_hsa050331.31407154
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27848065
23Wnt signaling pathway_Homo sapiens_hsa043101.24718078
24Nucleotide excision repair_Homo sapiens_hsa034201.24709057
25Colorectal cancer_Homo sapiens_hsa052101.24126109
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22222162
27Gap junction_Homo sapiens_hsa045401.21375946
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20505844
29Ribosome_Homo sapiens_hsa030101.19812720
30Glioma_Homo sapiens_hsa052141.19423515
31Olfactory transduction_Homo sapiens_hsa047401.17783772
32Dopaminergic synapse_Homo sapiens_hsa047281.17639047
33Endometrial cancer_Homo sapiens_hsa052131.15607555
34MicroRNAs in cancer_Homo sapiens_hsa052061.15195242
35RNA degradation_Homo sapiens_hsa030181.14340329
36Adherens junction_Homo sapiens_hsa045201.14153529
37Notch signaling pathway_Homo sapiens_hsa043301.12174421
38Tight junction_Homo sapiens_hsa045301.10035869
39Estrogen signaling pathway_Homo sapiens_hsa049151.09278882
40Amphetamine addiction_Homo sapiens_hsa050311.08614413
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08367876
42One carbon pool by folate_Homo sapiens_hsa006701.07772026
43Fanconi anemia pathway_Homo sapiens_hsa034601.07087376
44Melanogenesis_Homo sapiens_hsa049161.06966329
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.05767974
46Base excision repair_Homo sapiens_hsa034101.05417707
47Circadian entrainment_Homo sapiens_hsa047131.04958466
48Prostate cancer_Homo sapiens_hsa052151.04464770
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02130914
50Oxytocin signaling pathway_Homo sapiens_hsa049211.01671193
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.01556476
52Axon guidance_Homo sapiens_hsa043601.00757527
53Pyrimidine metabolism_Homo sapiens_hsa002401.00465091
54Glutamatergic synapse_Homo sapiens_hsa047240.98606450
55Thyroid cancer_Homo sapiens_hsa052160.97994905
56ErbB signaling pathway_Homo sapiens_hsa040120.97537984
57GnRH signaling pathway_Homo sapiens_hsa049120.97363641
58Pancreatic cancer_Homo sapiens_hsa052120.96836124
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95032418
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94293416
61Small cell lung cancer_Homo sapiens_hsa052220.93612799
62RNA polymerase_Homo sapiens_hsa030200.93275490
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92933881
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90909272
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90880151
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88788539
67GABAergic synapse_Homo sapiens_hsa047270.88403677
68Non-small cell lung cancer_Homo sapiens_hsa052230.88159767
69Homologous recombination_Homo sapiens_hsa034400.87747394
70Long-term depression_Homo sapiens_hsa047300.87313024
71Pyruvate metabolism_Homo sapiens_hsa006200.87241696
72TGF-beta signaling pathway_Homo sapiens_hsa043500.87172350
73Dorso-ventral axis formation_Homo sapiens_hsa043200.86749266
74Basal transcription factors_Homo sapiens_hsa030220.86223391
75Carbon metabolism_Homo sapiens_hsa012000.85890258
76Dilated cardiomyopathy_Homo sapiens_hsa054140.85151245
77Renal cell carcinoma_Homo sapiens_hsa052110.84915972
78VEGF signaling pathway_Homo sapiens_hsa043700.84619700
79Chronic myeloid leukemia_Homo sapiens_hsa052200.83206068
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.82965212
81Alcoholism_Homo sapiens_hsa050340.82442015
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81320359
83Insulin secretion_Homo sapiens_hsa049110.80088533
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79817951
85Gastric acid secretion_Homo sapiens_hsa049710.79245235
86Cholinergic synapse_Homo sapiens_hsa047250.79095556
87HTLV-I infection_Homo sapiens_hsa051660.79062810
88* Proteoglycans in cancer_Homo sapiens_hsa052050.77317586
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76893721
90Bladder cancer_Homo sapiens_hsa052190.76022920
91Salivary secretion_Homo sapiens_hsa049700.75294373
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74808810
93Morphine addiction_Homo sapiens_hsa050320.74676426
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74632211
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74572391
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74304294
97p53 signaling pathway_Homo sapiens_hsa041150.74013189
98Pentose phosphate pathway_Homo sapiens_hsa000300.74011381
99Lysine degradation_Homo sapiens_hsa003100.70808983
100Rap1 signaling pathway_Homo sapiens_hsa040150.69839678
101Pathways in cancer_Homo sapiens_hsa052000.69676060
102Selenocompound metabolism_Homo sapiens_hsa004500.69352518
103Glucagon signaling pathway_Homo sapiens_hsa049220.69092531
104Viral carcinogenesis_Homo sapiens_hsa052030.67013261
105Insulin signaling pathway_Homo sapiens_hsa049100.66669143
106Type II diabetes mellitus_Homo sapiens_hsa049300.66306100
107MAPK signaling pathway_Homo sapiens_hsa040100.66252704
108Purine metabolism_Homo sapiens_hsa002300.65729578
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64776271
110Vitamin B6 metabolism_Homo sapiens_hsa007500.64592697
111AMPK signaling pathway_Homo sapiens_hsa041520.64544831
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64437084
113Melanoma_Homo sapiens_hsa052180.63799515
114Calcium signaling pathway_Homo sapiens_hsa040200.63096194
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62647372
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.62606239
117Cocaine addiction_Homo sapiens_hsa050300.61523869
118Focal adhesion_Homo sapiens_hsa045100.60905292
119Renin secretion_Homo sapiens_hsa049240.60002963
120Choline metabolism in cancer_Homo sapiens_hsa052310.59030365
121HIF-1 signaling pathway_Homo sapiens_hsa040660.58971194
122Thyroid hormone synthesis_Homo sapiens_hsa049180.58728697
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57929569
124Acute myeloid leukemia_Homo sapiens_hsa052210.52399113
125Folate biosynthesis_Homo sapiens_hsa007900.52088973
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48417665
127ECM-receptor interaction_Homo sapiens_hsa045120.46225892
128Arginine biosynthesis_Homo sapiens_hsa002200.44964872
129Inositol phosphate metabolism_Homo sapiens_hsa005620.41700264
130Steroid biosynthesis_Homo sapiens_hsa001000.40966756
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37778467
132N-Glycan biosynthesis_Homo sapiens_hsa005100.37599531
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32203246

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