DSC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.86401373
2keratinocyte differentiation (GO:0030216)9.55626728
3intermediate filament organization (GO:0045109)8.82239742
4hemidesmosome assembly (GO:0031581)8.37731712
5water homeostasis (GO:0030104)8.34044501
6bundle of His cell to Purkinje myocyte communication (GO:0086069)7.42789163
7epidermal cell differentiation (GO:0009913)7.41432416
8epidermis development (GO:0008544)6.90035309
9skin morphogenesis (GO:0043589)6.68574503
10virion attachment to host cell (GO:0019062)6.23293028
11adhesion of symbiont to host cell (GO:0044650)6.23293028
12intermediate filament cytoskeleton organization (GO:0045104)5.85373028
13long-chain fatty acid biosynthetic process (GO:0042759)5.80687887
14ectoderm development (GO:0007398)5.78566837
15intermediate filament-based process (GO:0045103)5.67934758
16keratinocyte proliferation (GO:0043616)5.35316957
17lateral sprouting from an epithelium (GO:0060601)5.25251015
18fatty acid elongation (GO:0030497)5.14805222
19adhesion of symbiont to host (GO:0044406)5.07166822
20polarized epithelial cell differentiation (GO:0030859)4.62476431
21epithelial cell differentiation involved in prostate gland development (GO:0060742)4.51908361
22cell wall macromolecule metabolic process (GO:0044036)4.51905214
23cell wall macromolecule catabolic process (GO:0016998)4.51905214
24negative regulation of interferon-gamma production (GO:0032689)4.23387840
25phosphatidylcholine acyl-chain remodeling (GO:0036151)4.09839170
26keratinocyte development (GO:0003334)4.04732663
27linoleic acid metabolic process (GO:0043651)3.97544026
28skin development (GO:0043588)3.64593442
29ceramide biosynthetic process (GO:0046513)3.62289277
30hair follicle morphogenesis (GO:0031069)3.60383830
31negative regulation of cell fate specification (GO:0009996)3.58432432
32phosphatidylserine metabolic process (GO:0006658)3.49134113
33hair cycle process (GO:0022405)3.41723762
34molting cycle process (GO:0022404)3.41723762
35regulation of ruffle assembly (GO:1900027)3.39621666
36negative regulation of keratinocyte proliferation (GO:0010839)3.38067362
37atrioventricular valve morphogenesis (GO:0003181)3.37174151
38positive regulation of monocyte chemotaxis (GO:0090026)3.36048095
39detection of bacterium (GO:0016045)3.34293446
40phospholipid catabolic process (GO:0009395)3.32946272
41hair follicle development (GO:0001942)3.27507469
42surfactant homeostasis (GO:0043129)3.26906870
43epithelium development (GO:0060429)3.26414206
44sphingoid metabolic process (GO:0046519)3.23901231
45glucosamine-containing compound catabolic process (GO:1901072)3.20021929
46regulation of T cell chemotaxis (GO:0010819)3.19901985
47positive regulation of T cell chemotaxis (GO:0010820)3.19901985
48phosphatidylinositol acyl-chain remodeling (GO:0036149)3.18152000
49lipoxygenase pathway (GO:0019372)3.15978456
50negative regulation of interleukin-17 production (GO:0032700)3.12039357
51planar cell polarity pathway involved in neural tube closure (GO:0090179)3.08982294
52long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.08308933
53sphingosine metabolic process (GO:0006670)3.07676166
54chemical homeostasis within a tissue (GO:0048875)3.05699366
55regulation of keratinocyte proliferation (GO:0010837)3.05410692
56ventricular cardiac muscle cell action potential (GO:0086005)3.05199578
57establishment of tissue polarity (GO:0007164)3.04765015
58establishment of planar polarity (GO:0001736)3.04765015
59keratinization (GO:0031424)20.2503611
60regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.99352055
61detection of external biotic stimulus (GO:0098581)2.95274490
62regulation of cardioblast differentiation (GO:0051890)2.92543261
63sequestering of metal ion (GO:0051238)2.91805032
64regulation of hair cycle (GO:0042634)2.90864190
65regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.86391876
66polyol transport (GO:0015791)2.86371650
67alditol phosphate metabolic process (GO:0052646)2.85280069
68detection of other organism (GO:0098543)2.84457804
69cell-substrate junction assembly (GO:0007044)2.79206281
70diol metabolic process (GO:0034311)2.78463094
71long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77840357
72fibrinolysis (GO:0042730)2.77678959
73phospholipid efflux (GO:0033700)2.76751406
74phosphatidylserine acyl-chain remodeling (GO:0036150)2.75717194
75genitalia morphogenesis (GO:0035112)2.74212607
76one-carbon compound transport (GO:0019755)2.69630286
77intestinal epithelial cell development (GO:0060576)2.69215277
78negative regulation of epidermal cell differentiation (GO:0045605)2.69142976
79negative regulation of cell fate commitment (GO:0010454)2.67911630
80epithelial cell-cell adhesion (GO:0090136)2.66780780
81positive regulation of epidermis development (GO:0045684)2.65285531
82positive regulation of hair follicle development (GO:0051798)2.64048112
83positive regulation of hair cycle (GO:0042635)2.64048112
84negative regulation of stress fiber assembly (GO:0051497)2.62533663
85regulation of hair follicle development (GO:0051797)2.61960138
86positive regulation of cholesterol efflux (GO:0010875)2.61744992
87citrulline biosynthetic process (GO:0019240)2.61555342
88regulation of heart rate by cardiac conduction (GO:0086091)2.60556060
89positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.57645204
90sphingolipid biosynthetic process (GO:0030148)2.56665550
91defense response to fungus (GO:0050832)2.56492723
92regulation of axon regeneration (GO:0048679)2.55145464
93regulation of neuron projection regeneration (GO:0070570)2.55145464
94regulation of protein localization to cell surface (GO:2000008)2.54770439
95very long-chain fatty acid metabolic process (GO:0000038)2.54534959
96fatty-acyl-CoA metabolic process (GO:0035337)2.53564427
97fatty-acyl-CoA biosynthetic process (GO:0046949)2.53378694
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.52883939
99gland morphogenesis (GO:0022612)2.50635669
100detection of biotic stimulus (GO:0009595)2.50500814
101eyelid development in camera-type eye (GO:0061029)2.47794209
102hormone catabolic process (GO:0042447)2.47658869
103cell communication involved in cardiac conduction (GO:0086065)2.47131186
104regulation of keratinocyte differentiation (GO:0045616)2.46357342
105regulation of transforming growth factor beta1 production (GO:0032908)2.43995076
106regulation of epidermal cell differentiation (GO:0045604)2.43736267
107non-canonical Wnt signaling pathway (GO:0035567)2.43730353
108mitotic G1 DNA damage checkpoint (GO:0031571)2.40463397
109hair cell differentiation (GO:0035315)2.39887785
110phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.39282876
111regulation of cholesterol efflux (GO:0010874)2.38611275
112epithelial cell proliferation (GO:0050673)2.38560762
113phosphatidylglycerol metabolic process (GO:0046471)2.38088778
114regulation of monocyte chemotaxis (GO:0090025)2.37702824
115negative regulation of epidermis development (GO:0045683)2.36684111
116positive regulation of interleukin-8 secretion (GO:2000484)2.36481963
117regulation of cell fate specification (GO:0042659)2.36130448
118cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.35835818
119cellular response to antibiotic (GO:0071236)2.34322838
120positive regulation of sterol transport (GO:0032373)2.34128365
121positive regulation of cholesterol transport (GO:0032376)2.34128365
122cell surface receptor signaling pathway involved in heart development (GO:0061311)2.33870896
123negative regulation of cell aging (GO:0090344)2.32808503
124regulation of natural killer cell activation (GO:0032814)2.32112778
125smooth muscle tissue development (GO:0048745)2.31773146
126bone trabecula formation (GO:0060346)2.27472881
127tooth mineralization (GO:0034505)2.26293215
128phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.24957735
129regulation of epidermis development (GO:0045682)2.24828658
130sympathetic nervous system development (GO:0048485)2.24326470
131G1 DNA damage checkpoint (GO:0044783)2.23747679
132defense response to Gram-negative bacterium (GO:0050829)2.22802859
133regulation of fibroblast apoptotic process (GO:2000269)2.22128576
134positive regulation of epidermal cell differentiation (GO:0045606)2.20350431
135epithelial cell differentiation (GO:0030855)2.19075357
136regulation of natural killer cell differentiation (GO:0032823)2.18764983
137gap junction assembly (GO:0016264)2.18569790
138establishment of skin barrier (GO:0061436)17.6790243
139regulation of water loss via skin (GO:0033561)15.3045534
140molting cycle (GO:0042303)15.2245799
141hair cycle (GO:0042633)15.2245799
142desmosome organization (GO:0002934)14.6735643
143multicellular organismal water homeostasis (GO:0050891)10.1076110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.90980849
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.35590285
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.52459284
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.21803313
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18969783
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10910157
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.07794012
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.02078317
9SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.02078317
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.01116480
11FOXO3_23340844_ChIP-Seq_DLD1_Human2.00812091
12TP63_17297297_ChIP-ChIP_HaCaT_Human14.5746713
13ZNF263_19887448_ChIP-Seq_K562_Human1.98552765
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.71139457
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.62925626
16* TP63_23658742_ChIP-Seq_EP156T_Human1.60712347
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59956195
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54541578
19AR_21572438_ChIP-Seq_LNCaP_Human1.48652832
20GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.46130779
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.44474377
22RXR_22108803_ChIP-Seq_LS180_Human1.37667511
23TP53_18474530_ChIP-ChIP_U2OS_Human1.35983972
24GATA3_24758297_ChIP-Seq_MCF-7_Human1.33829468
25GATA6_21074721_ChIP-Seq_CACO-2_Human1.33116865
26CJUN_26792858_Chip-Seq_BT549_Human1.32149943
27SOX2_20726797_ChIP-Seq_SW620_Human1.31103088
28* TP63_22573176_ChIP-Seq_HFKS_Human1.29544812
29EGR1_19032775_ChIP-ChIP_M12_Human1.24987122
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21162776
31ATF3_27146783_Chip-Seq_COLON_Human1.20155020
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19866217
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.19689625
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19303065
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17376624
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17092436
37* KLF5_25053715_ChIP-Seq_YYC3_Human1.16898054
38RACK7_27058665_Chip-Seq_MCF-7_Human1.16484686
39BCAT_22108803_ChIP-Seq_LS180_Human1.13817459
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13193469
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13193469
42AHR_22903824_ChIP-Seq_MCF-7_Human1.12567089
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11442604
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.11179061
45CEBPB_22108803_ChIP-Seq_LS180_Human1.10326489
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09819046
47P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.09619750
48ERG_20517297_ChIP-Seq_VCAP_Human1.09090596
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07319718
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05326935
51BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05189357
52CTCF_27219007_Chip-Seq_Bcells_Human1.04209647
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.04035882
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03862315
55CTCF_20526341_ChIP-Seq_ESCs_Human1.03816063
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02955727
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01598192
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00647898
59RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99982082
60E2F1_20622854_ChIP-Seq_HELA_Human0.98849626
61GATA4_25053715_ChIP-Seq_YYC3_Human0.97797242
62SMAD4_21799915_ChIP-Seq_A2780_Human0.94755083
63DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93544567
64PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90339002
65* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90300576
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88385753
67CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88281286
68BCOR_27268052_Chip-Seq_Bcells_Human0.88024387
69CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87133005
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87130200
71EZH2_27304074_Chip-Seq_ESCs_Mouse0.86156898
72TP53_20018659_ChIP-ChIP_R1E_Mouse0.85972321
73TP53_16413492_ChIP-PET_HCT116_Human0.85878282
74JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84820240
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84411171
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84390565
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84311734
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84287671
79MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.83792952
80P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83747402
81TAF2_19829295_ChIP-Seq_ESCs_Human0.83551362
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83396919
83ESR1_20079471_ChIP-ChIP_T-47D_Human0.82583956
84OCT1_27270436_Chip-Seq_PROSTATE_Human0.82100640
85GATA1_22025678_ChIP-Seq_K562_Human0.81952168
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81829027
87NANOG_20526341_ChIP-Seq_ESCs_Human0.81635287
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81561912
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.81397823
90AR_25329375_ChIP-Seq_VCAP_Human0.80627450
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80388951
92GATA6_25053715_ChIP-Seq_YYC3_Human0.80356125
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79906410
94RBPJ_21746931_ChIP-Seq_IB4_Human0.79494192
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78295489
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78034850
97CSB_26484114_Chip-Seq_FIBROBLAST_Human0.77844627
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76837309
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.76672180
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75508095
101* CDX2_22108803_ChIP-Seq_LS180_Human0.74911544
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74829335
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74795026
104RNF2_27304074_Chip-Seq_ESCs_Mouse0.74782409
105P53_21459846_ChIP-Seq_SAOS-2_Human0.74348360
106HNFA_21074721_ChIP-Seq_CACO-2_Human0.74274033
107EZH2_27294783_Chip-Seq_ESCs_Mouse0.73947313
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.73828065
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.73760979
110LXR_22292898_ChIP-Seq_THP-1_Human0.73075999
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.72107046
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71058275
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.70752499
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.70677534
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68920862
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.68452416
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.68448557
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.68200032
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.67788819
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67024611
121RUNX_20019798_ChIP-Seq_JUKART_Human0.66960352
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.66888181
123NCOR_22424771_ChIP-Seq_293T_Human0.66578868
124HTT_18923047_ChIP-ChIP_STHdh_Human0.66520518
125FOXA1_21572438_ChIP-Seq_LNCaP_Human0.66198308
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.65928223
127TBL1_22424771_ChIP-Seq_293T_Human0.65710205
128AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65653709
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65625978
130P68_20966046_ChIP-Seq_HELA_Human0.65066960
131* TCF4_22108803_ChIP-Seq_LS180_Human0.64315151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier7.46958841
2MP0005275_abnormal_skin_tensile7.16588865
3MP0000579_abnormal_nail_morphology6.91511343
4* MP0005501_abnormal_skin_physiology4.56420981
5MP0000383_abnormal_hair_follicle4.37846790
6MP0010234_abnormal_vibrissa_follicle4.36124238
7MP0010678_abnormal_skin_adnexa3.96990999
8MP0000647_abnormal_sebaceous_gland3.75764817
9MP0002098_abnormal_vibrissa_morphology3.56007525
10MP0003941_abnormal_skin_development3.41961179
11* MP0001216_abnormal_epidermal_layer3.20462927
12MP0000427_abnormal_hair_cycle3.19669301
13MP0002060_abnormal_skin_morphology3.09308871
14MP0004381_abnormal_hair_follicle3.05620924
15MP0003705_abnormal_hypodermis_morpholog2.98300989
16* MP0010771_integument_phenotype2.91854203
17MP0002254_reproductive_system_inflammat2.91133199
18* MP0000377_abnormal_hair_follicle2.65803392
19* MP0004947_skin_inflammation2.65292086
20MP0003453_abnormal_keratinocyte_physiol2.49760276
21MP0000467_abnormal_esophagus_morphology2.46879350
22MP0005451_abnormal_body_composition2.31260235
23MP0005377_hearing/vestibular/ear_phenot2.20823535
24MP0003878_abnormal_ear_physiology2.20823535
25MP0000015_abnormal_ear_pigmentation1.93812278
26MP0001243_abnormal_dermal_layer1.90597834
27MP0000762_abnormal_tongue_morphology1.88940788
28MP0005174_abnormal_tail_pigmentation1.80186569
29MP0001188_hyperpigmentation1.74550776
30* MP0009931_abnormal_skin_appearance1.65363794
31MP0003566_abnormal_cell_adhesion1.56384812
32MP0001191_abnormal_skin_condition1.55020607
33MP0005409_darkened_coat_color1.53374518
34* MP0000367_abnormal_coat/_hair1.50554147
35MP0002095_abnormal_skin_pigmentation1.47476236
36MP0003191_abnormal_cellular_cholesterol1.43349456
37MP0004185_abnormal_adipocyte_glucose1.31777245
38MP0009379_abnormal_foot_pigmentation1.22408270
39MP0002234_abnormal_pharynx_morphology1.20238319
40MP0000566_synostosis1.13492576
41MP0002009_preneoplasia1.12806414
42MP0001346_abnormal_lacrimal_gland1.07723936
43MP0001851_eye_inflammation0.96400915
44MP0008438_abnormal_cutaneous_collagen0.94877694
45MP0005171_absent_coat_pigmentation0.89994896
46MP0001661_extended_life_span0.89832907
47MP0000569_abnormal_digit_pigmentation0.83736987
48MP0009053_abnormal_anal_canal0.82777299
49MP0000465_gastrointestinal_hemorrhage0.70442565
50MP0002177_abnormal_outer_ear0.68782402
51MP0005503_abnormal_tendon_morphology0.68511974
52MP0004782_abnormal_surfactant_physiolog0.67538434
53MP0005023_abnormal_wound_healing0.65498902
54* MP0001784_abnormal_fluid_regulation0.63317492
55MP0004264_abnormal_extraembryonic_tissu0.60042808
56MP0000372_irregular_coat_pigmentation0.59732370
57MP0010030_abnormal_orbit_morphology0.57579216
58MP0001849_ear_inflammation0.57254385
59* MP0001340_abnormal_eyelid_morphology0.57216769
60MP0002166_altered_tumor_susceptibility0.57005542
61MP0003950_abnormal_plasma_membrane0.55262812
62MP0009780_abnormal_chondrocyte_physiolo0.53401913
63MP0001984_abnormal_olfaction0.52817374
64MP0010352_gastrointestinal_tract_polyps0.51962240
65MP0002006_tumorigenesis0.51083512
66MP0003755_abnormal_palate_morphology0.48523572
67MP0002877_abnormal_melanocyte_morpholog0.47019980
68MP0009384_cardiac_valve_regurgitation0.46139770
69MP0000627_abnormal_mammary_gland0.44596722
70MP0004885_abnormal_endolymph0.41846069
71MP0008004_abnormal_stomach_pH0.38520293
72MP0002282_abnormal_trachea_morphology0.37362800
73MP0005666_abnormal_adipose_tissue0.37335066
74MP0002111_abnormal_tail_morphology0.36034503
75MP0000428_abnormal_craniofacial_morphol0.34588416
76MP0005075_abnormal_melanosome_morpholog0.33353450
77MP0008789_abnormal_olfactory_epithelium0.31778429
78MP0009333_abnormal_splenocyte_physiolog0.31487948
79MP0000538_abnormal_urinary_bladder0.31392233
80MP0005076_abnormal_cell_differentiation0.29991525
81MP0005257_abnormal_intraocular_pressure0.29422744
82MP0005408_hypopigmentation0.29402220
83MP0003638_abnormal_response/metabolism_0.29264528
84MP0005499_abnormal_olfactory_system0.29093797
85MP0005394_taste/olfaction_phenotype0.29093797
86MP0003315_abnormal_perineum_morphology0.27774031
87MP0002138_abnormal_hepatobiliary_system0.27711552
88MP0003385_abnormal_body_wall0.25230687
89MP0004272_abnormal_basement_membrane0.25058383
90MP0005375_adipose_tissue_phenotype0.25051963
91MP0000371_diluted_coat_color0.24815060
92MP0000537_abnormal_urethra_morphology0.24776062
93MP0006054_spinal_hemorrhage0.23239529
94MP0001177_atelectasis0.23170150
95MP0000685_abnormal_immune_system0.22403048
96MP0005248_abnormal_Harderian_gland0.22103719
97MP0001485_abnormal_pinna_reflex0.21368756
98MP0001299_abnormal_eye_distance/0.20639987
99MP0003011_delayed_dark_adaptation0.20332286
100MP0003828_pulmonary_edema0.19368778
101MP0002075_abnormal_coat/hair_pigmentati0.17851860
102* MP0000432_abnormal_head_morphology0.17736321
103MP0003329_amyloid_beta_deposits0.17735186
104MP0002249_abnormal_larynx_morphology0.17405052
105MP0002133_abnormal_respiratory_system0.16037950
106MP0005388_respiratory_system_phenotype0.16037950
107MP0000516_abnormal_urinary_system0.15627718
108MP0005367_renal/urinary_system_phenotyp0.15627718
109MP0002090_abnormal_vision0.15527705
110MP0006138_congestive_heart_failure0.15062921
111MP0003763_abnormal_thymus_physiology0.14625175
112MP0005647_abnormal_sex_gland0.14501367
113MP0004197_abnormal_fetal_growth/weight/0.14496146
114MP0001186_pigmentation_phenotype0.14477923
115MP0002896_abnormal_bone_mineralization0.13953152
116MP0002233_abnormal_nose_morphology0.13708628
117MP0008961_abnormal_basal_metabolism0.13563798
118MP0004742_abnormal_vestibular_system0.13028099
119MP0001958_emphysema0.12989760
120MP0000462_abnormal_digestive_system0.12613767
121MP0000613_abnormal_salivary_gland0.12505594
122MP0009672_abnormal_birth_weight0.11600932
123MP0005508_abnormal_skeleton_morphology0.11481524
124MP0003300_gastrointestinal_ulcer0.10947888
125MP0000470_abnormal_stomach_morphology0.10589260
126MP0003935_abnormal_craniofacial_develop0.09398134
127MP0000751_myopathy0.09346579

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.58138885
2Woolly hair (HP:0002224)8.41853286
3Pili torti (HP:0003777)8.27792448
4Hypotrichosis (HP:0001006)8.25073145
5Palmoplantar hyperkeratosis (HP:0000972)7.35895056
6Palmar hyperkeratosis (HP:0010765)6.97550284
7Plantar hyperkeratosis (HP:0007556)6.94342523
8Follicular hyperkeratosis (HP:0007502)6.54163968
9Thick nail (HP:0001805)6.12694252
10Erythema (HP:0010783)5.97028070
11Onycholysis (HP:0001806)5.93676939
12Conjunctival hamartoma (HP:0100780)5.86114353
13Congenital ichthyosiform erythroderma (HP:0007431)5.79612553
14Erythroderma (HP:0001019)5.59305281
15Right ventricular cardiomyopathy (HP:0011663)5.42075270
16Abnormal hair laboratory examination (HP:0003328)5.18476738
17Fragile nails (HP:0001808)5.17939963
18Alopecia of scalp (HP:0002293)5.00564408
19Oral leukoplakia (HP:0002745)4.77980014
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.39471150
21Milia (HP:0001056)4.31211631
22Nail dystrophy (HP:0008404)4.28735622
23Abnormal blistering of the skin (HP:0008066)4.19569237
24Gangrene (HP:0100758)3.99841148
25Sparse eyelashes (HP:0000653)3.91889892
26Parakeratosis (HP:0001036)3.84393694
27Hamartoma of the eye (HP:0010568)3.70709601
28Ectropion (HP:0000656)3.56884037
29Brittle hair (HP:0002299)3.51437799
30Corneal erosion (HP:0200020)3.50715740
31Palmoplantar keratoderma (HP:0000982)3.47388674
32Slow-growing hair (HP:0002217)3.44819765
33Abnormality of hair growth rate (HP:0011363)3.44819765
34Congenital, generalized hypertrichosis (HP:0004540)3.36977222
35Absent hair (HP:0002298)3.25663782
36Lip pit (HP:0100267)3.18859236
37Hypohidrosis (HP:0000966)3.13566602
38Pruritus (HP:0000989)3.10856579
39Advanced eruption of teeth (HP:0006288)2.99463909
40Natal tooth (HP:0000695)2.98538221
41Curly hair (HP:0002212)2.94793810
42Eczematoid dermatitis (HP:0000976)2.90188028
43Ridged nail (HP:0001807)2.75692787
44Selective tooth agenesis (HP:0001592)2.72265611
45Ventricular tachycardia (HP:0004756)2.68741062
46Hyporeflexia of lower limbs (HP:0002600)2.53830971
47Depressed nasal tip (HP:0000437)2.52289383
48Atrophic scars (HP:0001075)2.51901635
49Split foot (HP:0001839)2.51302944
50Hypergammaglobulinemia (HP:0010702)2.51170642
51Furrowed tongue (HP:0000221)2.42429687
52Laryngomalacia (HP:0001601)2.39764529
53Duplicated collecting system (HP:0000081)2.31373788
54Septate vagina (HP:0001153)2.21907708
55Conical tooth (HP:0000698)2.21658256
56Lack of skin elasticity (HP:0100679)2.20790124
57Sparse scalp hair (HP:0002209)2.18827501
58Nasolacrimal duct obstruction (HP:0000579)2.16743037
59Abnormality of the dental root (HP:0006486)2.14599744
60Taurodontia (HP:0000679)2.14599744
61Abnormality of permanent molar morphology (HP:0011071)2.14599744
62Anonychia (HP:0001798)2.13496857
63Pustule (HP:0200039)2.12470992
64Xerostomia (HP:0000217)2.12443511
65Corneal dystrophy (HP:0001131)2.09314678
66Acanthosis nigricans (HP:0000956)2.08971644
67Increased connective tissue (HP:0009025)2.07208568
68Blepharitis (HP:0000498)2.02585373
69Hyperhidrosis (HP:0000975)2.02346790
70Abnormality of molar morphology (HP:0011070)2.02043122
71Abnormality of molar (HP:0011077)2.02043122
72Aplasia involving bones of the upper limbs (HP:0009823)2.00742925
73Aplasia of the phalanges of the hand (HP:0009802)2.00742925
74Aplasia involving bones of the extremities (HP:0009825)2.00742925
75Abnormality of nail color (HP:0100643)10.0876137
76Ventricular fibrillation (HP:0001663)1.99307262
77Aplasia cutis congenita (HP:0001057)1.99165501
78Abnormality of the renal collecting system (HP:0004742)1.98569510
79Fatigable weakness (HP:0003473)1.97262947
80Abnormality of the neuromuscular junction (HP:0003398)1.97262947
81Fine hair (HP:0002213)1.95899084
82Abnormality of the dental pulp (HP:0006479)1.91937624
83Autoamputation (HP:0001218)1.90658720
84Type 1 muscle fiber predominance (HP:0003803)1.90546961
85Amelogenesis imperfecta (HP:0000705)1.85818582
86Amniotic constriction ring (HP:0009775)1.84498309
87Abnormality of placental membranes (HP:0011409)1.84498309
88Anhidrosis (HP:0000970)1.83587525
89Oligodontia (HP:0000677)1.83486115
90Hamartoma (HP:0010566)1.80383962
91Verrucae (HP:0200043)1.80127144
92Papilloma (HP:0012740)1.80127144
93Dry hair (HP:0011359)1.74095031
94Urticaria (HP:0001025)1.73722996
95Distal lower limb muscle weakness (HP:0009053)1.72507687
96Fragile skin (HP:0001030)1.72354840
97Melanocytic nevus (HP:0000995)1.72204500
98Recurrent corneal erosions (HP:0000495)1.72169686
99Breast hypoplasia (HP:0003187)1.72086943
100Abnormality of the lacrimal duct (HP:0011481)1.72052031
101Abnormality of secondary sexual hair (HP:0009888)1.70880962
102Abnormality of the axillary hair (HP:0100134)1.70880962
103Carious teeth (HP:0000670)1.68288590
104Abnormality of the fingernails (HP:0001231)1.67254498
105Skin ulcer (HP:0200042)1.67245154
106Abnormality of the frontal sinuses (HP:0002687)1.63592472
107Labial hypoplasia (HP:0000066)1.61727258
108Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.59529010
109Intention tremor (HP:0002080)1.58633607
110Round ear (HP:0100830)1.58182973
111Abnormality of the nasolacrimal system (HP:0000614)1.54878011
112Hypoplastic labia majora (HP:0000059)1.53930442
113Abnormality of the gastric mucosa (HP:0004295)1.53667694
114Absent eyelashes (HP:0000561)1.52874822
115Multifactorial inheritance (HP:0001426)1.52781983
116Abnormality of the salivary glands (HP:0010286)1.51827883
117Fair hair (HP:0002286)1.51630447
118Dehydration (HP:0001944)1.49061786
119Neck muscle weakness (HP:0000467)1.47035594
120Malignant hyperthermia (HP:0002047)1.46634151
121Generalized hypopigmentation of hair (HP:0011358)1.46557972
122Dry skin (HP:0000958)1.45393441
123Sudden death (HP:0001699)1.39003794
124Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.38336108
125Concave nail (HP:0001598)1.37276064
126Neonatal death (HP:0003811)1.36273611
127Abnormality of the labia majora (HP:0012881)1.36159630
128Muscle fiber inclusion bodies (HP:0100299)1.36022485
129Nemaline bodies (HP:0003798)1.32589212
130Achilles tendon contracture (HP:0001771)1.30972767
131Distal arthrogryposis (HP:0005684)1.26210124
132Areflexia of lower limbs (HP:0002522)1.24080264
133Sepsis (HP:0100806)1.23527227
134Rectal prolapse (HP:0002035)1.22318130
135Muscle fiber splitting (HP:0003555)1.22141934
136Severe Myopia (HP:0011003)1.21304156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR17.22240254
2FER4.55697930
3MAPKAPK34.25235437
4LATS13.97684248
5FGFR13.46545957
6MST1R3.43228766
7MST43.08005273
8MAP3K33.03784932
9MAP3K22.64348976
10FGFR22.60216592
11TTN2.51551434
12PIK3CG2.40466045
13EPHB22.25647872
14ERN12.23606466
15BCR2.16010041
16TAOK12.06868196
17MAPK71.94851134
18RPS6KB21.90460875
19FGFR31.84290755
20EPHA21.76626575
21TRPM71.66913745
22MAP3K91.64712012
23MAP3K61.56258409
24SGK4941.51934171
25SGK2231.51934171
26MAP3K111.49022389
27TRIB31.42261760
28MAP3K71.39591030
29PTK61.36705637
30NLK1.36102859
31IKBKB1.32888707
32SGK21.31616979
33EPHB11.31029121
34LATS21.28311697
35CDK61.27517636
36WNK11.26644463
37RPS6KB11.26440502
38MET1.26372169
39RIPK11.26160473
40OBSCN1.22311466
41TIE11.17898149
42MAP2K61.17028337
43EEF2K1.16544028
44EPHA31.16081757
45TGFBR21.06804333
46FRK1.06793308
47IRAK11.03049542
48RPS6KA41.02072962
49FGFR40.99952203
50PDGFRA0.99236363
51MAP3K10.96943776
52GRK60.96595385
53MAPKAPK20.95623958
54NTRK20.95452467
55ERBB30.92353739
56SGK30.91433680
57ICK0.90482810
58MAP2K30.90344114
59STK30.90277161
60LRRK20.89576900
61MAP2K40.88996379
62STK240.86985302
63MAPKAPK50.85946085
64CDK120.81008947
65KIT0.80826943
66SIK10.80810357
67STK100.78479253
68BLK0.76426869
69PRKCE0.76327996
70DMPK0.74400750
71BRD40.72418637
72DYRK1B0.67864445
73ADRBK10.66715827
74PRKAA20.66247372
75ITK0.64419985
76PKN10.62255082
77TESK10.61719574
78PRKD10.58893474
79PTK20.58571666
80ERBB40.56849140
81ERBB20.56359437
82TYK20.55612419
83MINK10.49754686
84FGR0.49322184
85BMPR1B0.49041823
86ACVR1B0.48592733
87STK38L0.47726187
88DDR20.47676243
89TYRO30.46258591
90PRPF4B0.45614475
91TAOK30.42925379
92MAP2K10.42557183
93RPS6KA10.40901152
94GRK70.40229621
95ABL10.39983399
96BMX0.39680499
97PDGFRB0.38684404
98STK110.38141773
99MAP3K50.37885215
100MARK20.37138987
101CSNK1D0.37128418
102JAK10.36437114
103LIMK10.35760553
104PAK30.35193405
105IKBKE0.34521251
106MAPK120.34009559
107AKT30.33558129
108PIM20.32917596
109PINK10.32630894
110EPHA40.32599648
111PHKG10.32428642
112PHKG20.32428642
113RET0.31461525
114CDK30.30400310
115CHUK0.30003560
116NEK60.29759850
117PBK0.29604969
118CAMK1D0.28998690
119NME10.28636313
120GSK3A0.27811593
121ROCK10.27322152
122FYN0.27091922
123PRKD20.24580094
124PRKCH0.23542029
125SRC0.23397994
126MAPK110.23211184
127STK380.22815326
128JAK30.22432978
129TAF10.21235382
130CSNK1E0.21069334
131IRAK20.20779191
132PRKCI0.20689033
133IGF1R0.19927958
134SGK10.19086195
135EGFR0.19057485
136MELK0.17996586
137HCK0.17728035
138CAMK1G0.17482795
139CDC42BPA0.16971875
140MTOR0.16196878
141ABL20.16065221
142MAPK90.15764922

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.37770582
2Linoleic acid metabolism_Homo sapiens_hsa005913.30750676
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.29676808
4Sphingolipid metabolism_Homo sapiens_hsa006002.29719430
5Arachidonic acid metabolism_Homo sapiens_hsa005902.25590413
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11241899
7Ether lipid metabolism_Homo sapiens_hsa005652.03261496
8Ovarian steroidogenesis_Homo sapiens_hsa049132.02430890
9Circadian rhythm_Homo sapiens_hsa047101.97815256
10Basal cell carcinoma_Homo sapiens_hsa052171.91791322
11Fat digestion and absorption_Homo sapiens_hsa049751.77557228
12Adherens junction_Homo sapiens_hsa045201.75613897
13Phenylalanine metabolism_Homo sapiens_hsa003601.68306771
14ECM-receptor interaction_Homo sapiens_hsa045121.64544988
15Tight junction_Homo sapiens_hsa045301.58665006
16Histidine metabolism_Homo sapiens_hsa003401.55049289
17Steroid biosynthesis_Homo sapiens_hsa001001.53937465
18VEGF signaling pathway_Homo sapiens_hsa043701.52071222
19Axon guidance_Homo sapiens_hsa043601.50903930
20Melanogenesis_Homo sapiens_hsa049161.48273146
21GnRH signaling pathway_Homo sapiens_hsa049121.47966406
22Hippo signaling pathway_Homo sapiens_hsa043901.47568250
23Dorso-ventral axis formation_Homo sapiens_hsa043201.40026122
24Staphylococcus aureus infection_Homo sapiens_hsa051501.35565118
25Proteoglycans in cancer_Homo sapiens_hsa052051.34721539
26Choline metabolism in cancer_Homo sapiens_hsa052311.32085121
27Phototransduction_Homo sapiens_hsa047441.26458749
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23307461
29Glioma_Homo sapiens_hsa052141.23247405
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22823230
31ABC transporters_Homo sapiens_hsa020101.19481435
32Hedgehog signaling pathway_Homo sapiens_hsa043401.17558257
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.17194183
34Renin secretion_Homo sapiens_hsa049241.13733413
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13192919
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12124024
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.10333360
38Long-term potentiation_Homo sapiens_hsa047201.09973702
39Bladder cancer_Homo sapiens_hsa052191.09826006
40Sphingolipid signaling pathway_Homo sapiens_hsa040711.09137892
41Mineral absorption_Homo sapiens_hsa049781.06957691
42Tyrosine metabolism_Homo sapiens_hsa003501.04133351
43MicroRNAs in cancer_Homo sapiens_hsa052061.00849788
44Amoebiasis_Homo sapiens_hsa051460.97943918
45Pertussis_Homo sapiens_hsa051330.97276044
46Long-term depression_Homo sapiens_hsa047300.95687015
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.95620999
48TGF-beta signaling pathway_Homo sapiens_hsa043500.95029897
49Caffeine metabolism_Homo sapiens_hsa002320.94338887
50Acute myeloid leukemia_Homo sapiens_hsa052210.94190433
51Thyroid cancer_Homo sapiens_hsa052160.92977860
52Gastric acid secretion_Homo sapiens_hsa049710.91874959
53Ras signaling pathway_Homo sapiens_hsa040140.88818191
54Wnt signaling pathway_Homo sapiens_hsa043100.85973008
55Focal adhesion_Homo sapiens_hsa045100.85615897
56Salivary secretion_Homo sapiens_hsa049700.85287663
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82340395
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.81519705
59Estrogen signaling pathway_Homo sapiens_hsa049150.80886638
60Protein digestion and absorption_Homo sapiens_hsa049740.80365395
61Platelet activation_Homo sapiens_hsa046110.80290600
62Retinol metabolism_Homo sapiens_hsa008300.79324968
63Pancreatic secretion_Homo sapiens_hsa049720.79045881
64Glutamatergic synapse_Homo sapiens_hsa047240.77749510
65Fatty acid biosynthesis_Homo sapiens_hsa000610.77099699
66Endometrial cancer_Homo sapiens_hsa052130.76502779
67ErbB signaling pathway_Homo sapiens_hsa040120.75371194
68Hepatitis C_Homo sapiens_hsa051600.75000429
69Rap1 signaling pathway_Homo sapiens_hsa040150.74347040
70p53 signaling pathway_Homo sapiens_hsa041150.73324020
71PPAR signaling pathway_Homo sapiens_hsa033200.73208277
72Toxoplasmosis_Homo sapiens_hsa051450.72183078
73Insulin resistance_Homo sapiens_hsa049310.69979696
74Oxytocin signaling pathway_Homo sapiens_hsa049210.69688939
75Circadian entrainment_Homo sapiens_hsa047130.66953031
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64206556
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64192204
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63856522
79Inositol phosphate metabolism_Homo sapiens_hsa005620.63629775
80Serotonergic synapse_Homo sapiens_hsa047260.63194522
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62649722
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60893418
83Non-small cell lung cancer_Homo sapiens_hsa052230.59371546
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56457142
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54743974
86Endocytosis_Homo sapiens_hsa041440.54241047
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.54236418
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54105758
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53992425
90Olfactory transduction_Homo sapiens_hsa047400.53617562
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.52578190
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51955337
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51754392
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51562220
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51266674
96Renal cell carcinoma_Homo sapiens_hsa052110.50148594
97Small cell lung cancer_Homo sapiens_hsa052220.49263499
98beta-Alanine metabolism_Homo sapiens_hsa004100.48394342
99Chemical carcinogenesis_Homo sapiens_hsa052040.48100139
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47822812
101Amphetamine addiction_Homo sapiens_hsa050310.47793156
102Tuberculosis_Homo sapiens_hsa051520.47296869
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46705457
104Pathways in cancer_Homo sapiens_hsa052000.46695939
105cAMP signaling pathway_Homo sapiens_hsa040240.46345353
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45098095
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44666846
108Notch signaling pathway_Homo sapiens_hsa043300.44221565
109Dilated cardiomyopathy_Homo sapiens_hsa054140.43690875
110Melanoma_Homo sapiens_hsa052180.43173298
111MAPK signaling pathway_Homo sapiens_hsa040100.42484391
112Salmonella infection_Homo sapiens_hsa051320.42125602
113Prostate cancer_Homo sapiens_hsa052150.41341945
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40660318
115Glucagon signaling pathway_Homo sapiens_hsa049220.40116717
116Calcium signaling pathway_Homo sapiens_hsa040200.40006667
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39202992
118Dopaminergic synapse_Homo sapiens_hsa047280.37230332
119Insulin signaling pathway_Homo sapiens_hsa049100.37194766
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33888545
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.33721442
122Vitamin digestion and absorption_Homo sapiens_hsa049770.31420547
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27056071
124Nitrogen metabolism_Homo sapiens_hsa009100.26803805
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.26687676

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