DSC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.49680178
2keratinization (GO:0031424)9.27892385
3keratinocyte proliferation (GO:0043616)7.78807611
4keratinocyte differentiation (GO:0030216)7.70312099
5molting cycle (GO:0042303)7.27030459
6hair cycle (GO:0042633)7.27030459
7bundle of His cell to Purkinje myocyte communication (GO:0086069)7.11014358
8multicellular organismal water homeostasis (GO:0050891)6.89984982
9sphingoid metabolic process (GO:0046519)6.11225887
10epidermal cell differentiation (GO:0009913)5.97924091
11intermediate filament organization (GO:0045109)5.80882517
12water homeostasis (GO:0030104)5.76004176
13polarized epithelial cell differentiation (GO:0030859)5.74759078
14gap junction assembly (GO:0016264)5.73770171
15epidermis development (GO:0008544)5.61160479
16peptide cross-linking (GO:0018149)5.61140357
17regulation of phospholipase A2 activity (GO:0032429)5.58985395
18sphingosine metabolic process (GO:0006670)5.58242202
19epithelial cell differentiation involved in prostate gland development (GO:0060742)5.28209026
20keratinocyte development (GO:0003334)5.26046746
21diol metabolic process (GO:0034311)4.96803657
22interferon-gamma secretion (GO:0072643)4.87997306
23surfactant homeostasis (GO:0043129)4.50261093
24viral transcription (GO:0019083)4.41685201
25regulation of chemokine secretion (GO:0090196)4.35548057
26negative regulation of keratinocyte proliferation (GO:0010839)4.34445946
27glucosamine-containing compound catabolic process (GO:1901072)4.29219244
28gland morphogenesis (GO:0022612)4.18729358
29regulation of ruffle assembly (GO:1900027)4.16943176
30translational termination (GO:0006415)4.14504557
31regulation of cell proliferation involved in kidney development (GO:1901722)4.14492032
32regulation of keratinocyte differentiation (GO:0045616)4.03837856
33chemical homeostasis within a tissue (GO:0048875)3.95684574
34positive regulation of interleukin-8 secretion (GO:2000484)3.92559605
35ribosomal small subunit biogenesis (GO:0042274)3.90382515
36ectoderm development (GO:0007398)3.86504043
37ventricular cardiac muscle cell action potential (GO:0086005)3.86341594
38long-chain fatty acid biosynthetic process (GO:0042759)3.86177819
39negative regulation of cell fate specification (GO:0009996)3.84243310
40skin morphogenesis (GO:0043589)3.77862061
41intestinal epithelial cell development (GO:0060576)3.71578056
42planar cell polarity pathway involved in neural tube closure (GO:0090179)3.69464257
43negative regulation of epidermis development (GO:0045683)3.64316172
44fatty acid elongation (GO:0030497)3.59916097
45virion attachment to host cell (GO:0019062)3.59114034
46adhesion of symbiont to host cell (GO:0044650)3.59114034
47atrioventricular valve morphogenesis (GO:0003181)3.58949451
48cardiac right ventricle morphogenesis (GO:0003215)3.56498178
49intermediate filament cytoskeleton organization (GO:0045104)3.55951306
50regulation of epidermis development (GO:0045682)3.55922067
51negative regulation of cell fate commitment (GO:0010454)3.52334528
52cellular response to interferon-alpha (GO:0035457)3.46871749
53intermediate filament-based process (GO:0045103)3.46076715
54lipoxygenase pathway (GO:0019372)3.41332763
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38179082
56regulation of heart rate by cardiac conduction (GO:0086091)3.37214088
57positive regulation of chemokine secretion (GO:0090197)3.36574847
58regulation of hair follicle development (GO:0051797)3.28565965
59viral life cycle (GO:0019058)3.28074083
60detection of bacterium (GO:0016045)3.27865120
61prostanoid biosynthetic process (GO:0046457)3.22726900
62prostaglandin biosynthetic process (GO:0001516)3.22726900
63phosphatidylinositol acyl-chain remodeling (GO:0036149)3.20776009
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.20424536
65translational elongation (GO:0006414)3.19521372
66regulation of glomerular filtration (GO:0003093)3.18995689
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18319112
68protein targeting to ER (GO:0045047)3.14039741
69negative regulation of kidney development (GO:0090185)3.11652458
70regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.11087950
71regulation of epidermal cell differentiation (GO:0045604)3.10867414
72cotranslational protein targeting to membrane (GO:0006613)3.10549099
73cell communication involved in cardiac conduction (GO:0086065)3.10523576
74eyelid development in camera-type eye (GO:0061029)3.08647904
75regulation of interleukin-8 secretion (GO:2000482)3.07422023
76establishment of planar polarity (GO:0001736)3.05660646
77establishment of tissue polarity (GO:0007164)3.05660646
78establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05458950
79cellular protein complex disassembly (GO:0043624)3.05400525
80G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.04980765
81genitalia morphogenesis (GO:0035112)3.04814506
82lateral sprouting from an epithelium (GO:0060601)3.04684527
83negative regulation of interferon-gamma production (GO:0032689)3.02641179
84negative regulation of stress fiber assembly (GO:0051497)3.00297483
85negative regulation of epidermal cell differentiation (GO:0045605)2.99829564
86regulation of hypersensitivity (GO:0002883)2.99416202
87cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.97912116
88negative regulation of interleukin-2 production (GO:0032703)2.97713027
89positive regulation of keratinocyte differentiation (GO:0045618)2.97672475
90heart valve morphogenesis (GO:0003179)2.97565946
91cell-substrate junction assembly (GO:0007044)2.95627072
92regulation of keratinocyte proliferation (GO:0010837)2.95070638
93skin development (GO:0043588)2.94340850
94regulation of transforming growth factor beta2 production (GO:0032909)2.93612333
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92134759
96morphogenesis of embryonic epithelium (GO:0016331)2.91625635
97epithelium development (GO:0060429)2.90386362
98protein localization to endoplasmic reticulum (GO:0070972)2.88853581
99phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.88211571
100maturation of SSU-rRNA (GO:0030490)2.85957180
101mitotic G1 DNA damage checkpoint (GO:0031571)2.85780871
102cardiac muscle cell action potential involved in contraction (GO:0086002)2.84869412
103epithelial cell proliferation (GO:0050673)2.81940470
104prostate gland epithelium morphogenesis (GO:0060740)2.80391475
105cell junction organization (GO:0034330)2.79992638
106limb bud formation (GO:0060174)2.79418039
107phosphatidylserine acyl-chain remodeling (GO:0036150)2.77945496
108molting cycle process (GO:0022404)2.77452241
109hair cycle process (GO:0022405)2.77452241
110positive regulation of vesicle fusion (GO:0031340)2.77368447
111phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77146941
112positive regulation of epidermis development (GO:0045684)2.76277786
113regulation of cardioblast differentiation (GO:0051890)2.76230510
114regulation of hair cycle (GO:0042634)2.75428256
115cardiac muscle cell action potential (GO:0086001)2.75243873
116prostanoid metabolic process (GO:0006692)2.73619626
117prostaglandin metabolic process (GO:0006693)2.73619626
118hair follicle development (GO:0001942)2.73286809
119cell junction assembly (GO:0034329)2.73201706
120ribosomal small subunit assembly (GO:0000028)2.72829590
121mesenchymal to epithelial transition (GO:0060231)2.72755453
122phosphatidylcholine acyl-chain remodeling (GO:0036151)2.72173897
123detection of other organism (GO:0098543)2.70231478
124non-canonical Wnt signaling pathway (GO:0035567)2.68375895
125linoleic acid metabolic process (GO:0043651)2.67747927
126primary alcohol catabolic process (GO:0034310)2.67642430
127hair follicle morphogenesis (GO:0031069)2.66959888
128cardiac conduction (GO:0061337)2.66318443
129adhesion of symbiont to host (GO:0044406)2.64472316
130cell adhesion mediated by integrin (GO:0033627)2.63412446
131positive regulation of epidermal cell differentiation (GO:0045606)2.63249343
132positive regulation of interleukin-4 production (GO:0032753)2.62979793
133cell-cell junction assembly (GO:0007043)2.62943601
134cyclooxygenase pathway (GO:0019371)2.62060699
135mitotic G1/S transition checkpoint (GO:0044819)2.61973994
136G1 DNA damage checkpoint (GO:0044783)2.61716453
137smooth muscle tissue development (GO:0048745)2.60663244
138morphogenesis of an epithelial fold (GO:0060571)2.59842105
139negative regulation of cell aging (GO:0090344)2.59285483
140phosphatidylserine metabolic process (GO:0006658)2.56298579
141positive regulation of hair follicle development (GO:0051798)2.56178233
142positive regulation of hair cycle (GO:0042635)2.56178233
143regulation of transforming growth factor beta1 production (GO:0032908)2.50798758
144plasma membrane repair (GO:0001778)2.49994275
145epithelial cell-cell adhesion (GO:0090136)2.48137581
146Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.47831058
147regulation of establishment of planar polarity (GO:0090175)2.45006696
148desmosome organization (GO:0002934)17.0148834
149establishment of skin barrier (GO:0061436)10.7680917
150regulation of water loss via skin (GO:0033561)10.0214753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.78173820
2SOX9_24532713_ChIP-Seq_HFSC_Mouse3.10310467
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.75079279
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38874061
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.30964536
6ZNF263_19887448_ChIP-Seq_K562_Human2.22307730
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.11734024
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.07333134
9TP63_17297297_ChIP-ChIP_HaCaT_Human16.4355219
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.91305575
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.91305575
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86941263
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.78281339
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.66125001
15AR_21572438_ChIP-Seq_LNCaP_Human1.65871661
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62721790
17TCF4_18268006_ChIP-ChIP_LS174T_Human1.48772608
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48189721
19* TP63_23658742_ChIP-Seq_EP156T_Human1.34651121
20SOX2_20726797_ChIP-Seq_SW620_Human1.31446441
21TP53_18474530_ChIP-ChIP_U2OS_Human1.29284925
22CJUN_26792858_Chip-Seq_BT549_Human1.28803067
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27686460
24RXR_22108803_ChIP-Seq_LS180_Human1.25862584
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.20740423
26BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.20729663
27KLF5_25053715_ChIP-Seq_YYC3_Human1.18478691
28AHR_22903824_ChIP-Seq_MCF-7_Human1.16310450
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.15648125
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13446164
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.10168999
32* TP63_22573176_ChIP-Seq_HFKS_Human1.09853029
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07272115
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05854615
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03521147
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01640669
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00357601
38BCAT_22108803_ChIP-Seq_LS180_Human0.99814594
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99714548
40EED_16625203_ChIP-ChIP_MESCs_Mouse0.99632553
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97000765
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95063705
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94192290
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93569696
45CDX2_20551321_ChIP-Seq_CACO-2_Human0.91789139
46JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91202723
47TP53_16413492_ChIP-PET_HCT116_Human0.90989611
48RACK7_27058665_Chip-Seq_MCF-7_Human0.90309041
49CLOCK_20551151_ChIP-Seq_293T_Human0.89791805
50* UBF1/2_26484160_Chip-Seq_HMECs_Human0.89317749
51RNF2_27304074_Chip-Seq_ESCs_Mouse0.89280669
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87976759
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87481796
54BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86183137
55GATA4_25053715_ChIP-Seq_YYC3_Human0.84472942
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84178797
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83483717
58PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83409996
59GATA1_22025678_ChIP-Seq_K562_Human0.82990411
60EZH2_27294783_Chip-Seq_ESCs_Mouse0.82943887
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82691363
62RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82514437
63EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82514437
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82446522
65GATA3_24758297_ChIP-Seq_MCF-7_Human0.82439607
66ESR1_20079471_ChIP-ChIP_T-47D_Human0.82297937
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82079379
68ARNT_22903824_ChIP-Seq_MCF-7_Human0.80283582
69JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79384685
70FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77518974
71P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76446682
72SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75473908
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75432342
74RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75275320
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75182163
76GATA6_25053715_ChIP-Seq_YYC3_Human0.73921861
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73259365
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72986923
79ERG_21242973_ChIP-ChIP_JURKAT_Human0.72972999
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.72567169
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72494772
82* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.72370098
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.71339424
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.71261818
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.71180686
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.70774668
87AR_21909140_ChIP-Seq_LNCAP_Human0.70259573
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70151119
89TBX20_22328084_ChIP-Seq_HEART_Mouse0.69953701
90TBX20_22080862_ChIP-Seq_HEART_Mouse0.69953701
91CTCF_27219007_Chip-Seq_Bcells_Human0.69920796
92* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69854368
93* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69854368
94ATF3_27146783_Chip-Seq_COLON_Human0.69637408
95* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69534172
96EGR1_19032775_ChIP-ChIP_M12_Human0.69377642
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.68536628
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.67983162
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.67455337
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.65511186
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.65138938
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.65119664
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65047230
104* CEBPB_22108803_ChIP-Seq_LS180_Human0.64892458
105* TCF4_22108803_ChIP-Seq_LS180_Human0.64631184
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64234274
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.63802335
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63769845
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.62977930
110MTF2_20144788_ChIP-Seq_MESCs_Mouse0.62851790
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.62183919
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.61980795
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.60987242
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.60713904
115BRD4_25478319_ChIP-Seq_HGPS_Human0.60158791
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59421204
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.58945368
118RING1B_27294783_Chip-Seq_NPCs_Mouse0.58934262
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58841708
120VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.57857872
121CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.57726392
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.57589262
123RBPJ_21746931_ChIP-Seq_IB4_Human0.57526597
124CDX2_22108803_ChIP-Seq_LS180_Human0.56756356
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54860100
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.53697489
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.53368789
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.53239630
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.53029572
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.52716512
131HNFA_21074721_ChIP-Seq_CACO-2_Human0.52561478
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.52479992
133ETV1_20927104_ChIP-Seq_GIST48_Human0.48697297
134CHD1_26751641_Chip-Seq_LNCaP_Human0.47927768
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.47696140
136ELK4_26923725_Chip-Seq_MESODERM_Mouse0.47497994
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.47164019
138HTT_18923047_ChIP-ChIP_STHdh_Human0.47126072
139PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.46520065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.93128684
2MP0005275_abnormal_skin_tensile5.16095128
3MP0003941_abnormal_skin_development4.91566350
4MP0010234_abnormal_vibrissa_follicle4.78995040
5MP0005501_abnormal_skin_physiology4.24855150
6MP0000579_abnormal_nail_morphology4.18081260
7MP0002254_reproductive_system_inflammat4.12167544
8MP0000383_abnormal_hair_follicle4.12115949
9MP0004381_abnormal_hair_follicle3.67021085
10MP0010678_abnormal_skin_adnexa3.59796431
11MP0002098_abnormal_vibrissa_morphology3.52795944
12MP0002060_abnormal_skin_morphology3.52088438
13* MP0001216_abnormal_epidermal_layer3.35178601
14MP0010771_integument_phenotype2.95388236
15MP0000647_abnormal_sebaceous_gland2.92468119
16MP0000566_synostosis2.79604837
17MP0000377_abnormal_hair_follicle2.68868385
18MP0000467_abnormal_esophagus_morphology2.68573802
19* MP0003453_abnormal_keratinocyte_physiol2.59437170
20MP0000427_abnormal_hair_cycle2.59075591
21MP0004947_skin_inflammation2.38232057
22MP0001346_abnormal_lacrimal_gland2.37863970
23MP0003705_abnormal_hypodermis_morpholog2.19864482
24MP0009379_abnormal_foot_pigmentation2.17402642
25MP0000762_abnormal_tongue_morphology2.11839329
26MP0003566_abnormal_cell_adhesion2.11759166
27MP0002009_preneoplasia1.85488718
28MP0001188_hyperpigmentation1.74003112
29* MP0009931_abnormal_skin_appearance1.57815614
30MP0004185_abnormal_adipocyte_glucose1.53383661
31MP0004885_abnormal_endolymph1.47879474
32MP0002234_abnormal_pharynx_morphology1.47138159
33* MP0001191_abnormal_skin_condition1.44782152
34MP0001243_abnormal_dermal_layer1.39390828
35* MP0000367_abnormal_coat/_hair1.33538802
36MP0001851_eye_inflammation1.31781545
37MP0010030_abnormal_orbit_morphology1.27937049
38MP0001340_abnormal_eyelid_morphology1.27784135
39MP0005377_hearing/vestibular/ear_phenot1.08028563
40MP0003878_abnormal_ear_physiology1.08028563
41MP0005023_abnormal_wound_healing1.06217710
42MP0005451_abnormal_body_composition1.05570164
43MP0001849_ear_inflammation1.03974106
44MP0009053_abnormal_anal_canal1.03490975
45MP0000015_abnormal_ear_pigmentation0.97617471
46MP0002177_abnormal_outer_ear0.97524230
47MP0005367_renal/urinary_system_phenotyp0.97148354
48MP0000516_abnormal_urinary_system0.97148354
49MP0010352_gastrointestinal_tract_polyps0.96295408
50MP0002877_abnormal_melanocyte_morpholog0.94034939
51MP0008789_abnormal_olfactory_epithelium0.93570711
52MP0000537_abnormal_urethra_morphology0.92351221
53MP0005409_darkened_coat_color0.92230894
54MP0008438_abnormal_cutaneous_collagen0.89899006
55MP0002249_abnormal_larynx_morphology0.88433882
56MP0003011_delayed_dark_adaptation0.88140217
57MP0000465_gastrointestinal_hemorrhage0.85297614
58MP0005174_abnormal_tail_pigmentation0.82781577
59MP0009780_abnormal_chondrocyte_physiolo0.80615260
60MP0002095_abnormal_skin_pigmentation0.78786975
61MP0000627_abnormal_mammary_gland0.78067506
62MP0003755_abnormal_palate_morphology0.74602598
63MP0002006_tumorigenesis0.72993462
64MP0005076_abnormal_cell_differentiation0.69889241
65MP0002282_abnormal_trachea_morphology0.68804293
66MP0000538_abnormal_urinary_bladder0.67341221
67MP0002233_abnormal_nose_morphology0.65144683
68MP0005257_abnormal_intraocular_pressure0.64997472
69MP0005394_taste/olfaction_phenotype0.63930206
70MP0005499_abnormal_olfactory_system0.63930206
71MP0003763_abnormal_thymus_physiology0.61532815
72MP0002166_altered_tumor_susceptibility0.61493901
73MP0005508_abnormal_skeleton_morphology0.60596649
74MP0004272_abnormal_basement_membrane0.59924818
75MP0000613_abnormal_salivary_gland0.59360232
76MP0002111_abnormal_tail_morphology0.59296449
77MP0009384_cardiac_valve_regurgitation0.57595084
78MP0003136_yellow_coat_color0.57384941
79MP0003315_abnormal_perineum_morphology0.57111924
80MP0004019_abnormal_vitamin_homeostasis0.57108999
81MP0008004_abnormal_stomach_pH0.56479999
82MP0009250_abnormal_appendicular_skeleto0.55517218
83MP0003950_abnormal_plasma_membrane0.55137519
84MP0001299_abnormal_eye_distance/0.53065178
85MP0002277_abnormal_respiratory_mucosa0.52783353
86MP0004782_abnormal_surfactant_physiolog0.52394182
87MP0000569_abnormal_digit_pigmentation0.51369822
88MP0001784_abnormal_fluid_regulation0.49690157
89MP0005503_abnormal_tendon_morphology0.48685813
90MP0003938_abnormal_ear_development0.46141932
91MP0000432_abnormal_head_morphology0.44776426
92MP0005248_abnormal_Harderian_gland0.44491564
93MP0003436_decreased_susceptibility_to0.43960410
94MP0003191_abnormal_cellular_cholesterol0.43696154
95MP0001984_abnormal_olfaction0.42837640
96MP0004264_abnormal_extraembryonic_tissu0.42329568
97MP0005197_abnormal_uvea_morphology0.41482710
98MP0003385_abnormal_body_wall0.40640507
99MP0005193_abnormal_anterior_eye0.39211564
100MP0000462_abnormal_digestive_system0.36853338
101MP0003638_abnormal_response/metabolism_0.36438896
102MP0004197_abnormal_fetal_growth/weight/0.34356789
103MP0006138_congestive_heart_failure0.33995437
104MP0001958_emphysema0.33770594
105MP0002109_abnormal_limb_morphology0.33339888
106MP0008260_abnormal_autophagy0.33197776
107MP0005666_abnormal_adipose_tissue0.33043068
108MP0005075_abnormal_melanosome_morpholog0.31986125
109MP0006054_spinal_hemorrhage0.31936221
110MP0000470_abnormal_stomach_morphology0.31932177
111MP0003045_fibrosis0.31855865
112MP0002133_abnormal_respiratory_system0.31642398
113MP0005388_respiratory_system_phenotype0.31642398
114MP0002148_abnormal_hypersensitivity_rea0.30725594
115MP0005390_skeleton_phenotype0.30264984
116MP0001186_pigmentation_phenotype0.29307325
117MP0000678_abnormal_parathyroid_gland0.29274385
118MP0000049_abnormal_middle_ear0.29197912
119MP0003935_abnormal_craniofacial_develop0.28620420
120MP0000428_abnormal_craniofacial_morphol0.27701596
121MP0002697_abnormal_eye_size0.27192534
122MP0002896_abnormal_bone_mineralization0.26922548
123MP0000858_altered_metastatic_potential0.26719098
124MP0000163_abnormal_cartilage_morphology0.25756367
125MP0003936_abnormal_reproductive_system0.25605315
126MP0003300_gastrointestinal_ulcer0.25382619
127MP0003937_abnormal_limbs/digits/tail_de0.24524699

Predicted human phenotypes

RankGene SetZ-score
1Plantar hyperkeratosis (HP:0007556)7.09721384
2Woolly hair (HP:0002224)6.98157532
3Fragile nails (HP:0001808)6.63480711
4Palmoplantar hyperkeratosis (HP:0000972)6.19581841
5Onycholysis (HP:0001806)6.17570111
6Lip pit (HP:0100267)6.13665265
7Right ventricular cardiomyopathy (HP:0011663)6.09549797
8* Hypotrichosis (HP:0001006)5.97057688
9Palmar hyperkeratosis (HP:0010765)5.87109586
10Milia (HP:0001056)5.60937988
11Parakeratosis (HP:0001036)5.32791825
12Pili torti (HP:0003777)5.24504708
13Abnormality of nail color (HP:0100643)5.18469130
14Erythema (HP:0010783)5.14602503
15Increased IgE level (HP:0003212)5.01432685
16Congenital ichthyosiform erythroderma (HP:0007431)5.00124459
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.75726538
18Thick nail (HP:0001805)4.65741583
19Erythroderma (HP:0001019)4.52297284
20Abnormal blistering of the skin (HP:0008066)4.38857018
21Oral leukoplakia (HP:0002745)4.12142652
22Nail dystrophy (HP:0008404)4.02862531
23Conjunctival hamartoma (HP:0100780)3.94623516
24Selective tooth agenesis (HP:0001592)3.76641129
25Popliteal pterygium (HP:0009756)3.75146228
26Atrophic scars (HP:0001075)3.74665967
27Sparse eyelashes (HP:0000653)3.73507623
28* Abnormality of secondary sexual hair (HP:0009888)3.73434765
29* Abnormality of the axillary hair (HP:0100134)3.73434765
30Natal tooth (HP:0000695)3.66443546
31Alopecia of scalp (HP:0002293)3.41387339
32Abnormal hair laboratory examination (HP:0003328)3.38004782
33Advanced eruption of teeth (HP:0006288)3.31891428
34Ectropion (HP:0000656)3.28466582
35Ventricular tachycardia (HP:0004756)3.07177212
36Aplasia cutis congenita (HP:0001057)3.06805017
37Hypohidrosis (HP:0000966)3.02672676
38Corneal erosion (HP:0200020)2.96725693
39Ridged nail (HP:0001807)2.94621098
40Hypoplastic labia majora (HP:0000059)2.93869105
41Acanthosis nigricans (HP:0000956)2.88976368
42Dry hair (HP:0011359)2.88183711
43Palmoplantar keratoderma (HP:0000982)2.80975064
44Absent hair (HP:0002298)2.79416539
45Distal lower limb muscle weakness (HP:0009053)2.79218521
46Curly hair (HP:0002212)2.75185156
47Gangrene (HP:0100758)2.68581389
48Hyporeflexia of lower limbs (HP:0002600)2.67651115
49Abnormality of the labia majora (HP:0012881)2.66286771
50Congenital, generalized hypertrichosis (HP:0004540)2.63415132
51Duplicated collecting system (HP:0000081)2.59868000
52Pruritus (HP:0000989)2.59522873
53Pterygium (HP:0001059)2.58998368
54Split foot (HP:0001839)2.49283761
55Abnormality of the salivary glands (HP:0010286)2.44798583
56Abnormality of cells of the erythroid lineage (HP:0012130)2.44196469
57Fragile skin (HP:0001030)2.42730282
58Follicular hyperkeratosis (HP:0007502)2.42610028
59Abnormality of the dental root (HP:0006486)2.41686989
60Taurodontia (HP:0000679)2.41686989
61Abnormality of permanent molar morphology (HP:0011071)2.41686989
62Abnormality of hair growth rate (HP:0011363)2.38964027
63Slow-growing hair (HP:0002217)2.38964027
64Down-sloping shoulders (HP:0200021)2.38354659
65Concave nail (HP:0001598)2.37987094
66Xerostomia (HP:0000217)2.35172356
67Ventricular fibrillation (HP:0001663)2.30972320
68Abnormality of the gastric mucosa (HP:0004295)2.29362994
69Abnormality of molar (HP:0011077)2.27187218
70Abnormality of molar morphology (HP:0011070)2.27187218
71Hypoplasia of dental enamel (HP:0006297)2.23633899
72Hamartoma of the eye (HP:0010568)2.23020494
73Aplasia involving bones of the upper limbs (HP:0009823)2.22187942
74Aplasia of the phalanges of the hand (HP:0009802)2.22187942
75Aplasia involving bones of the extremities (HP:0009825)2.22187942
76Abnormal hemoglobin (HP:0011902)2.21001206
77Abnormality of the renal collecting system (HP:0004742)2.20799456
78Oligodontia (HP:0000677)2.18949965
79Skin pits (HP:0100276)2.16365129
80Abnormality of placental membranes (HP:0011409)2.16176766
81Amniotic constriction ring (HP:0009775)2.16176766
82Abnormality of the neuromuscular junction (HP:0003398)2.14475944
83Fatigable weakness (HP:0003473)2.14475944
84Amelogenesis imperfecta (HP:0000705)2.13792459
85Abnormality of the dental pulp (HP:0006479)2.12342807
86Brittle hair (HP:0002299)2.11416891
87Nasolacrimal duct obstruction (HP:0000579)2.08755813
88Blepharitis (HP:0000498)2.07023943
89Hypodontia (HP:0000668)2.06468560
90Severe Myopia (HP:0011003)2.05947786
91Carious teeth (HP:0000670)2.04525267
92Depressed nasal tip (HP:0000437)2.04469365
93Breast hypoplasia (HP:0003187)2.04141072
94Melanocytic nevus (HP:0000995)2.03861251
95Abnormality of the lacrimal duct (HP:0011481)2.02619704
96Abnormal number of erythroid precursors (HP:0012131)2.01457413
97Abnormality of the distal phalanges of the toes (HP:0010182)1.99683002
98Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.97229913
99Absent eyebrow (HP:0002223)1.96359353
100* Sparse scalp hair (HP:0002209)1.95812333
101Premature loss of primary teeth (HP:0006323)1.89016282
102Anhidrosis (HP:0000970)1.87948549
103Anonychia (HP:0001798)1.87821442
104Cutaneous finger syndactyly (HP:0010554)1.81762415
105Ankyloglossia (HP:0010296)1.80629873
106Septate vagina (HP:0001153)1.79493586
107Labial hypoplasia (HP:0000066)1.79416268
108Stenosis of the external auditory canal (HP:0000402)1.78799552
109Abnormality of the fingernails (HP:0001231)1.78597889
110Reticulocytopenia (HP:0001896)1.77825158
111Bifid scrotum (HP:0000048)1.74902894
112Increased connective tissue (HP:0009025)1.74080362
113Dry skin (HP:0000958)1.73005930
114Areflexia of lower limbs (HP:0002522)1.72875563
115Neonatal death (HP:0003811)1.72630163
116Furrowed tongue (HP:0000221)1.72438394
117Dehydration (HP:0001944)1.71951424
118Esophageal atresia (HP:0002032)1.71729230
119Absent eyelashes (HP:0000561)1.71520244
120Skin ulcer (HP:0200042)1.70438065
121Abnormality of the nasolacrimal system (HP:0000614)1.70357072
122Laryngomalacia (HP:0001601)1.69760738
123Hyperhidrosis (HP:0000975)1.68848358
124Morphological abnormality of the middle ear (HP:0008609)1.64136330
125Hypoplastic female external genitalia (HP:0012815)1.62006425
126Conical tooth (HP:0000698)1.61918508
127Corneal dystrophy (HP:0001131)1.60934061
128Humeroradial synostosis (HP:0003041)1.60608218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.16559756
2MAP3K34.62394570
3MAPKAPK34.26814473
4FER3.35673400
5MAP3K23.07628497
6MST42.76852230
7EPHB22.74975576
8RPS6KB22.64089606
9LATS12.40034889
10STK242.37535716
11CDK122.24774811
12TRPM72.18260822
13FGFR22.13606524
14ERN12.10394428
15MET2.09572400
16BMPR1B1.81330424
17PIM21.76551669
18SIK11.75660906
19PIK3CG1.74511375
20MAPKAPK51.66154450
21MAPK151.60770396
22ARAF1.57354625
23EPHA31.55339107
24BCR1.51265496
25EEF2K1.49563370
26LRRK21.39477378
27ERBB31.37264838
28FGFR41.37105032
29CDK31.28966430
30NTRK11.28731357
31PDGFRA1.15366955
32STK101.13541091
33NTRK21.13278117
34FGFR31.10375341
35PTK61.05309524
36RPS6KA41.03938009
37TYK21.02044078
38BLK1.00949727
39CDK61.00844419
40EPHA20.97980604
41BRD40.97472288
42MAP3K10.92827376
43SGK2230.90415682
44SGK4940.90415682
45DYRK1B0.90287431
46RPS6KB10.89341823
47MAPKAPK20.88984726
48TGFBR20.87275156
49WNK10.86897994
50KSR20.83690632
51PBK0.82394813
52EPHB10.80744101
53MAP3K140.80722861
54MAP2K60.79175027
55IRAK30.79147536
56MAP3K110.78106330
57TAOK10.75143464
58TGFBR10.71012208
59FGFR10.70500152
60DMPK0.69989807
61LATS20.69816328
62SMG10.69457502
63FLT30.67382155
64TTN0.67263560
65MTOR0.64812123
66HIPK20.62086886
67GRK70.60456619
68ILK0.59195039
69PDGFRB0.59165972
70RIPK10.58675579
71ERBB20.57645242
72MAP2K20.56209286
73ITK0.54242550
74MAP3K70.54038341
75GRK10.53936655
76TESK10.53870854
77NLK0.53840205
78EPHA40.52146903
79PRKD10.51637340
80TRIB30.49794702
81STK380.49373193
82CAMK1G0.48773174
83MAP3K130.48524971
84CASK0.48464847
85RET0.48051072
86SGK30.47517288
87EIF2AK20.47115648
88PTK20.45900936
89PRKCE0.45612489
90RPS6KA20.45608199
91FRK0.45437252
92IKBKB0.45317867
93OBSCN0.44766611
94STK38L0.43876885
95PRKCI0.43414209
96ICK0.43257025
97IKBKE0.43132473
98RAF10.42389816
99ADRBK10.42360743
100MAP2K10.42314826
101RIPK40.41630269
102LMTK20.41048015
103CDK190.39843051
104PRKD20.39836665
105CAMK1D0.39333108
106STK30.36166312
107IRAK10.36129398
108RPS6KA10.35725873
109SGK20.35569245
110RPS6KL10.35546600
111RPS6KC10.35546600
112MAP3K60.35403810
113ROCK10.34120537
114CSNK1D0.32559580
115STK110.32186337
116PAK40.31811651
117CDC42BPA0.31750112
118NME10.31625913
119MAP3K90.31375487
120GSK3A0.31001889
121SGK10.30882893
122PRKAA20.30273413
123PKN10.29797248
124CHUK0.28352668
125MAPK110.27886939
126JAK20.27764665
127GRK60.27549717
128ABL10.26254882
129IGF1R0.26026598
130MAPK70.24942435
131MAPK120.24650311
132MOS0.23959659
133RPS6KA60.23934362
134TNK20.23541606
135MAPK90.20267876
136BMX0.18154997
137NEK60.17325514

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.07629461
2Ribosome_Homo sapiens_hsa030103.62942262
3Sphingolipid metabolism_Homo sapiens_hsa006003.05551232
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.95105537
5Linoleic acid metabolism_Homo sapiens_hsa005912.82367446
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66313538
7Arachidonic acid metabolism_Homo sapiens_hsa005902.48620086
8Basal cell carcinoma_Homo sapiens_hsa052172.40025350
9Retinol metabolism_Homo sapiens_hsa008302.27976941
10Fatty acid elongation_Homo sapiens_hsa000622.20599591
11Phenylalanine metabolism_Homo sapiens_hsa003602.07803946
12ECM-receptor interaction_Homo sapiens_hsa045121.79738054
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79365003
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63401900
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62760600
16Axon guidance_Homo sapiens_hsa043601.60773398
17Circadian rhythm_Homo sapiens_hsa047101.59668422
18Histidine metabolism_Homo sapiens_hsa003401.57463390
19Hippo signaling pathway_Homo sapiens_hsa043901.53190261
20Ether lipid metabolism_Homo sapiens_hsa005651.51467951
21Adherens junction_Homo sapiens_hsa045201.50385707
22Chemical carcinogenesis_Homo sapiens_hsa052041.45442186
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44901273
24Hedgehog signaling pathway_Homo sapiens_hsa043401.30782175
25p53 signaling pathway_Homo sapiens_hsa041151.30775385
26Caffeine metabolism_Homo sapiens_hsa002321.29826009
27Melanogenesis_Homo sapiens_hsa049161.29239678
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27465076
29VEGF signaling pathway_Homo sapiens_hsa043701.27371757
30Proteoglycans in cancer_Homo sapiens_hsa052051.26748503
31Glioma_Homo sapiens_hsa052141.22870903
32Tight junction_Homo sapiens_hsa045301.22568893
33Tyrosine metabolism_Homo sapiens_hsa003501.17354856
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16687195
35Choline metabolism in cancer_Homo sapiens_hsa052311.10883235
36Staphylococcus aureus infection_Homo sapiens_hsa051501.07605638
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.06832115
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.04888834
39Bladder cancer_Homo sapiens_hsa052191.01899090
40Amoebiasis_Homo sapiens_hsa051461.01855991
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00856273
42TGF-beta signaling pathway_Homo sapiens_hsa043500.95468936
43GnRH signaling pathway_Homo sapiens_hsa049120.93871832
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93220416
45MicroRNAs in cancer_Homo sapiens_hsa052060.91937716
46Wnt signaling pathway_Homo sapiens_hsa043100.91633761
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90516753
48Renin secretion_Homo sapiens_hsa049240.90044634
49Pancreatic cancer_Homo sapiens_hsa052120.89883003
50Toxoplasmosis_Homo sapiens_hsa051450.88713450
51Inositol phosphate metabolism_Homo sapiens_hsa005620.86704566
52Notch signaling pathway_Homo sapiens_hsa043300.85002668
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83307776
54Thyroid cancer_Homo sapiens_hsa052160.82120496
55Pancreatic secretion_Homo sapiens_hsa049720.81250081
56Renal cell carcinoma_Homo sapiens_hsa052110.81053643
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80901261
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79990788
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.77579040
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.76050718
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73893502
62Ras signaling pathway_Homo sapiens_hsa040140.73714378
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.73572391
64Phototransduction_Homo sapiens_hsa047440.73494265
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73485654
66Serotonergic synapse_Homo sapiens_hsa047260.72597522
67Protein digestion and absorption_Homo sapiens_hsa049740.71842389
68Dorso-ventral axis formation_Homo sapiens_hsa043200.70682329
69Small cell lung cancer_Homo sapiens_hsa052220.70364357
70Ovarian steroidogenesis_Homo sapiens_hsa049130.70249347
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69342009
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68613089
73ABC transporters_Homo sapiens_hsa020100.68418141
74Melanoma_Homo sapiens_hsa052180.67982148
75beta-Alanine metabolism_Homo sapiens_hsa004100.67207239
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.66913011
77Platelet activation_Homo sapiens_hsa046110.65770588
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.65282043
79Long-term depression_Homo sapiens_hsa047300.63968750
80Hepatitis C_Homo sapiens_hsa051600.62871276
81Insulin signaling pathway_Homo sapiens_hsa049100.62407067
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.62368443
83Rap1 signaling pathway_Homo sapiens_hsa040150.60528398
84ErbB signaling pathway_Homo sapiens_hsa040120.60359121
85Mineral absorption_Homo sapiens_hsa049780.60292289
86Endocytosis_Homo sapiens_hsa041440.58475620
87Chronic myeloid leukemia_Homo sapiens_hsa052200.58020363
88Pathways in cancer_Homo sapiens_hsa052000.57491482
89Focal adhesion_Homo sapiens_hsa045100.53152906
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52893870
91Dilated cardiomyopathy_Homo sapiens_hsa054140.52793901
92Gastric acid secretion_Homo sapiens_hsa049710.52038071
93Endometrial cancer_Homo sapiens_hsa052130.51799005
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48910380
95Pertussis_Homo sapiens_hsa051330.48818741
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.47442136
97Vitamin digestion and absorption_Homo sapiens_hsa049770.47336707
98Steroid biosynthesis_Homo sapiens_hsa001000.46718284
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46702061
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46551461
101T cell receptor signaling pathway_Homo sapiens_hsa046600.46017274
102Glutathione metabolism_Homo sapiens_hsa004800.43621212
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42010215
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41774761
105Acute myeloid leukemia_Homo sapiens_hsa052210.41738986
106Prostate cancer_Homo sapiens_hsa052150.41299099
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39806967
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39651754
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38443288
110Long-term potentiation_Homo sapiens_hsa047200.38429367
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37965155
112Fatty acid biosynthesis_Homo sapiens_hsa000610.37818629
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37729206
114Salmonella infection_Homo sapiens_hsa051320.37524796
115Estrogen signaling pathway_Homo sapiens_hsa049150.37281563
116Glucagon signaling pathway_Homo sapiens_hsa049220.36581398
117Fat digestion and absorption_Homo sapiens_hsa049750.36352070
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36288482
119Insulin resistance_Homo sapiens_hsa049310.35733195
120Oxytocin signaling pathway_Homo sapiens_hsa049210.35032780
121TNF signaling pathway_Homo sapiens_hsa046680.34923720
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34675522
123HTLV-I infection_Homo sapiens_hsa051660.34404752
124Glycerolipid metabolism_Homo sapiens_hsa005610.34380899
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.34162001
126Non-small cell lung cancer_Homo sapiens_hsa052230.33760998
127Hematopoietic cell lineage_Homo sapiens_hsa046400.33123440
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32291138
129Salivary secretion_Homo sapiens_hsa049700.32167749

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