DSCAML1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.16305280
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.91683166
3synaptic vesicle maturation (GO:0016188)5.82912495
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.59114871
5locomotory exploration behavior (GO:0035641)5.40264854
6vocalization behavior (GO:0071625)5.25245793
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18854916
8protein localization to synapse (GO:0035418)5.16418903
9synaptic vesicle exocytosis (GO:0016079)5.03884381
10regulation of glutamate receptor signaling pathway (GO:1900449)4.80554909
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.79623522
12glutamate secretion (GO:0014047)4.67079758
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.66862866
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.65637331
15regulation of synaptic vesicle exocytosis (GO:2000300)4.64796496
16neuron cell-cell adhesion (GO:0007158)4.62820853
17central nervous system myelination (GO:0022010)4.51202953
18axon ensheathment in central nervous system (GO:0032291)4.51202953
19synaptic transmission, glutamatergic (GO:0035249)4.39549286
20glutamate receptor signaling pathway (GO:0007215)4.30627825
21positive regulation of synapse maturation (GO:0090129)4.28792834
22regulation of neuronal synaptic plasticity (GO:0048168)4.24272784
23exploration behavior (GO:0035640)4.23344461
24regulation of synaptic vesicle transport (GO:1902803)4.16983290
25neurotransmitter-gated ion channel clustering (GO:0072578)4.13346142
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13054604
27neuron-neuron synaptic transmission (GO:0007270)3.97503825
28layer formation in cerebral cortex (GO:0021819)3.95929028
29cellular potassium ion homeostasis (GO:0030007)3.95894405
30positive regulation of membrane potential (GO:0045838)3.94950959
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92661133
32neurotransmitter secretion (GO:0007269)3.88328471
33neuronal ion channel clustering (GO:0045161)3.88319667
34amino acid import (GO:0043090)3.87025412
35dendritic spine morphogenesis (GO:0060997)3.85585043
36regulation of synapse structural plasticity (GO:0051823)3.83014813
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.81941100
38long-term memory (GO:0007616)3.81880387
39regulation of rhodopsin mediated signaling pathway (GO:0022400)3.78740634
40rhodopsin mediated signaling pathway (GO:0016056)3.75388361
41regulation of postsynaptic membrane potential (GO:0060078)3.70567412
42sodium ion export (GO:0071436)3.68746160
43membrane hyperpolarization (GO:0060081)3.67373026
44retinal cone cell development (GO:0046549)3.64995427
45synaptic vesicle endocytosis (GO:0048488)3.62180433
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.56300632
47gamma-aminobutyric acid transport (GO:0015812)3.55671551
48dendrite morphogenesis (GO:0048813)3.53536178
49axonal fasciculation (GO:0007413)3.51267388
50innervation (GO:0060384)3.49699443
51regulation of dendritic spine morphogenesis (GO:0061001)3.48655169
52pyrimidine nucleobase catabolic process (GO:0006208)3.46967875
53* neuron recognition (GO:0008038)3.46456077
54urinary tract smooth muscle contraction (GO:0014848)3.44246921
55postsynaptic membrane organization (GO:0001941)3.42307697
56regulation of neurotransmitter secretion (GO:0046928)3.41185428
57regulation of synapse maturation (GO:0090128)3.40408810
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.40012130
59detection of light stimulus involved in sensory perception (GO:0050962)3.39495347
60detection of light stimulus involved in visual perception (GO:0050908)3.39495347
61regulation of synaptic plasticity (GO:0048167)3.36255566
62negative regulation of dendrite development (GO:2000171)3.35683808
63response to pheromone (GO:0019236)3.33624788
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.32497237
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31024528
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.28998369
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28806712
68establishment of mitochondrion localization (GO:0051654)3.28488863
69long-term synaptic potentiation (GO:0060291)3.28099105
70regulation of vesicle fusion (GO:0031338)3.27703523
71neurotransmitter transport (GO:0006836)3.27367643
72neuronal action potential propagation (GO:0019227)3.24553011
73startle response (GO:0001964)3.24308469
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.23748282
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17480793
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15001791
77positive regulation of action potential (GO:0045760)3.14778959
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13415339
79cerebellar Purkinje cell differentiation (GO:0021702)3.12895286
80cell communication by electrical coupling (GO:0010644)3.12831747
81membrane depolarization (GO:0051899)3.12470379
82neuromuscular process controlling balance (GO:0050885)3.12465609
83regulation of neurotransmitter levels (GO:0001505)3.12465234
84transmission of nerve impulse (GO:0019226)3.12247395
85response to auditory stimulus (GO:0010996)3.12037831
86proline transport (GO:0015824)3.11731475
87behavioral fear response (GO:0001662)3.10587881
88behavioral defense response (GO:0002209)3.10587881
89central nervous system projection neuron axonogenesis (GO:0021952)3.10292679
90auditory behavior (GO:0031223)3.10092532
91nucleobase catabolic process (GO:0046113)3.08416970
92cerebellar granule cell differentiation (GO:0021707)3.07317324
93positive regulation of neurotransmitter transport (GO:0051590)3.06408416
94regulation of neurotransmitter transport (GO:0051588)3.05494976
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04964905
96L-amino acid import (GO:0043092)3.04382070
97detection of calcium ion (GO:0005513)3.04319402
98regulation of voltage-gated calcium channel activity (GO:1901385)3.03310766
99presynaptic membrane assembly (GO:0097105)3.03111175
100positive regulation of dendritic spine development (GO:0060999)3.01452461
101photoreceptor cell development (GO:0042461)3.00668517
102positive regulation of neurotransmitter secretion (GO:0001956)3.00554090
103membrane depolarization during action potential (GO:0086010)2.99704089
104chemosensory behavior (GO:0007635)2.98873681
105learning (GO:0007612)2.97326577
106regulation of ARF protein signal transduction (GO:0032012)2.96720414
107retinal rod cell development (GO:0046548)2.96551711
108cell migration in hindbrain (GO:0021535)2.96163903
109glycosphingolipid biosynthetic process (GO:0006688)2.95627305
110response to histamine (GO:0034776)2.95549000
111potassium ion homeostasis (GO:0055075)2.95251598
112presynaptic membrane organization (GO:0097090)2.93997029
113regulation of dendritic spine development (GO:0060998)2.93422348
114synapse assembly (GO:0007416)2.92681920
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91460360
116dopamine receptor signaling pathway (GO:0007212)2.90586984
117mechanosensory behavior (GO:0007638)2.85426968
118membrane assembly (GO:0071709)2.84040100
119righting reflex (GO:0060013)2.80374534
120potassium ion import (GO:0010107)2.76956908
121cAMP-mediated signaling (GO:0019933)2.76924728
122negative regulation of axonogenesis (GO:0050771)2.75058808
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73309876
124adult walking behavior (GO:0007628)2.73185279
125regulation of synaptic transmission, GABAergic (GO:0032228)2.70580870
126negative regulation of dendrite morphogenesis (GO:0050774)2.70310782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28186804
2GBX2_23144817_ChIP-Seq_PC3_Human3.23673184
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94625088
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94318035
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82157596
6DROSHA_22980978_ChIP-Seq_HELA_Human2.69147308
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63227052
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63227052
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60933487
10REST_21632747_ChIP-Seq_MESCs_Mouse2.54865773
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50040385
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.49126884
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47642370
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43641169
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41469696
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.37352361
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.36952238
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32784268
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25501218
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.25258004
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.15445235
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09514127
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09513397
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.08166918
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03665468
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95066833
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91607574
28AR_21572438_ChIP-Seq_LNCaP_Human1.86615649
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71584750
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68044017
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67493451
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56389198
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52292910
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.52031810
35IGF1R_20145208_ChIP-Seq_DFB_Human1.48112093
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47018735
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.46379545
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.41026921
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40254227
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39600876
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38636180
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.38030383
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.35109888
44* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32944933
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31480956
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.28328735
47P300_19829295_ChIP-Seq_ESCs_Human1.25437644
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24463021
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23454658
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23262537
51KDM2B_26808549_Chip-Seq_K562_Human1.22734610
52* AR_19668381_ChIP-Seq_PC3_Human1.22535614
53* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22283967
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20915258
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20486433
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18225061
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.17487056
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16216041
59STAT3_23295773_ChIP-Seq_U87_Human1.16028937
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15627034
61AR_25329375_ChIP-Seq_VCAP_Human1.15392193
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13290693
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11445667
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11257377
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10547228
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10545963
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08385464
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06267087
69* SMAD3_21741376_ChIP-Seq_HESCs_Human1.06101705
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05399615
71TAF15_26573619_Chip-Seq_HEK293_Human1.05164471
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04894016
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04769170
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04463407
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03574789
76TCF4_23295773_ChIP-Seq_U87_Human1.03152714
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02219010
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.01452894
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01296030
80AHR_22903824_ChIP-Seq_MCF-7_Human1.00921287
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.00835641
82* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00519756
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99599653
84* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99438720
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99142262
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99142262
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.99061519
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98721729
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98090491
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97944905
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97183208
92BCAT_22108803_ChIP-Seq_LS180_Human0.97148451
93KDM2B_26808549_Chip-Seq_REH_Human0.96977074
94* RNF2_27304074_Chip-Seq_NSC_Mouse0.96769769
95VDR_22108803_ChIP-Seq_LS180_Human0.96298403
96* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94010536
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92182796
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91640108
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91585241
100TP53_16413492_ChIP-PET_HCT116_Human0.91123225
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90557215
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90276646
103* ZNF274_21170338_ChIP-Seq_K562_Hela0.90089400
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89308386
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88601825
106ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87203528
107* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86963847
108* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86794127
109* CTCF_27219007_Chip-Seq_Bcells_Human0.86469195
110* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84910181
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.84442529
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.83982893
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83490208
114ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82353594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.49013520
2MP0003880_abnormal_central_pattern4.54705913
3* MP0003635_abnormal_synaptic_transmissio3.84500264
4MP0005551_abnormal_eye_electrophysiolog3.51366352
5MP0005423_abnormal_somatic_nervous3.42943261
6MP0004270_analgesia3.30116685
7MP0002063_abnormal_learning/memory/cond3.14761074
8MP0009745_abnormal_behavioral_response3.04423193
9MP0002064_seizures2.93695682
10MP0009046_muscle_twitch2.76430905
11MP0001486_abnormal_startle_reflex2.55817057
12MP0001968_abnormal_touch/_nociception2.55155454
13MP0002572_abnormal_emotion/affect_behav2.53897165
14MP0002272_abnormal_nervous_system2.51982148
15MP0002734_abnormal_mechanical_nocicepti2.37816043
16MP0002735_abnormal_chemical_nociception2.29258741
17MP0006072_abnormal_retinal_apoptosis2.21105328
18MP0005253_abnormal_eye_physiology2.11930977
19MP0000778_abnormal_nervous_system2.11845823
20MP0002822_catalepsy1.93903027
21MP0001984_abnormal_olfaction1.93551613
22MP0002736_abnormal_nociception_after1.92477939
23MP0002184_abnormal_innervation1.92290432
24MP0008569_lethality_at_weaning1.92259231
25MP0001501_abnormal_sleep_pattern1.88592493
26MP0004885_abnormal_endolymph1.82657721
27MP0003011_delayed_dark_adaptation1.81398571
28MP0002067_abnormal_sensory_capabilities1.77815407
29MP0004858_abnormal_nervous_system1.76743767
30* MP0002882_abnormal_neuron_morphology1.75850242
31MP0001502_abnormal_circadian_rhythm1.74617571
32MP0003787_abnormal_imprinting1.72174355
33MP0004811_abnormal_neuron_physiology1.71446073
34MP0001440_abnormal_grooming_behavior1.69930206
35MP0001970_abnormal_pain_threshold1.66599706
36MP0005645_abnormal_hypothalamus_physiol1.65038380
37MP0002733_abnormal_thermal_nociception1.61243223
38MP0000955_abnormal_spinal_cord1.58554349
39MP0002229_neurodegeneration1.57933741
40MP0002557_abnormal_social/conspecific_i1.55974827
41MP0003329_amyloid_beta_deposits1.48359449
42MP0005386_behavior/neurological_phenoty1.46513403
43MP0004924_abnormal_behavior1.46513403
44MP0002090_abnormal_vision1.46250366
45MP0009780_abnormal_chondrocyte_physiolo1.45359869
46MP0005646_abnormal_pituitary_gland1.43632629
47MP0003879_abnormal_hair_cell1.43532097
48* MP0005195_abnormal_posterior_eye1.39346578
49MP0001346_abnormal_lacrimal_gland1.35825243
50MP0002066_abnormal_motor_capabilities/c1.34184696
51MP0003183_abnormal_peptide_metabolism1.33824210
52* MP0002752_abnormal_somatic_nervous1.30651118
53MP0002909_abnormal_adrenal_gland1.26481249
54MP0001348_abnormal_lacrimal_gland1.26050620
55MP0002653_abnormal_ependyma_morphology1.22992600
56MP0004510_myositis1.19603226
57MP0002152_abnormal_brain_morphology1.17266801
58MP0006292_abnormal_olfactory_placode1.16970560
59MP0005394_taste/olfaction_phenotype1.16176661
60MP0005499_abnormal_olfactory_system1.16176661
61MP0003633_abnormal_nervous_system1.16118668
62MP0002638_abnormal_pupillary_reflex1.15464832
63MP0004742_abnormal_vestibular_system1.13720285
64MP0002876_abnormal_thyroid_physiology1.11925336
65MP0004142_abnormal_muscle_tone1.05264881
66MP0003634_abnormal_glial_cell1.04363146
67MP0004043_abnormal_pH_regulation1.03335090
68MP0003631_nervous_system_phenotype1.03036283
69MP0003122_maternal_imprinting0.98267504
70MP0006276_abnormal_autonomic_nervous0.98033268
71MP0000569_abnormal_digit_pigmentation0.96281084
72MP0001963_abnormal_hearing_physiology0.94555866
73MP0001177_atelectasis0.92451501
74MP0000631_abnormal_neuroendocrine_gland0.91959782
75MP0002069_abnormal_eating/drinking_beha0.90733582
76MP0000920_abnormal_myelination0.89203631
77MP0008872_abnormal_physiological_respon0.86581473
78MP0005391_vision/eye_phenotype0.86008454
79MP0001529_abnormal_vocalization0.83659332
80MP0003632_abnormal_nervous_system0.82914459
81MP0003075_altered_response_to0.81351808
82MP0001324_abnormal_eye_pigmentation0.78078583
83MP0005167_abnormal_blood-brain_barrier0.76470004
84MP0004145_abnormal_muscle_electrophysio0.75269505
85MP0001905_abnormal_dopamine_level0.74481274
86MP0001188_hyperpigmentation0.73565333
87MP0008874_decreased_physiological_sensi0.72997948
88MP0008789_abnormal_olfactory_epithelium0.72651853
89MP0003861_abnormal_nervous_system0.71320608
90MP0005535_abnormal_body_temperature0.70358128
91MP0004233_abnormal_muscle_weight0.69717061
92MP0003137_abnormal_impulse_conducting0.68552517
93MP0005623_abnormal_meninges_morphology0.68429168
94MP0004085_abnormal_heartbeat0.66890982
95MP0010386_abnormal_urinary_bladder0.66598411
96MP0001943_abnormal_respiration0.66343463
97MP0004215_abnormal_myocardial_fiber0.65596075
98MP0008877_abnormal_DNA_methylation0.64908806
99MP0002254_reproductive_system_inflammat0.64510514
100MP0001944_abnormal_pancreas_morphology0.63783455
101MP0003172_abnormal_lysosome_physiology0.63731668
102MP0001485_abnormal_pinna_reflex0.63436900
103MP0003121_genomic_imprinting0.62673231
104* MP0002082_postnatal_lethality0.61919208
105* MP0010770_preweaning_lethality0.61919208
106MP0000026_abnormal_inner_ear0.61457447
107* MP0010769_abnormal_survival0.61103031
108MP0001986_abnormal_taste_sensitivity0.60785985
109MP0000604_amyloidosis0.60265914
110MP0003690_abnormal_glial_cell0.60235105
111MP0004133_heterotaxia0.59273089
112MP0003119_abnormal_digestive_system0.57928666
113* MP0010768_mortality/aging0.57728723
114MP0003123_paternal_imprinting0.56573914
115MP0002234_abnormal_pharynx_morphology0.54670203
116MP0005409_darkened_coat_color0.53999723
117MP0000516_abnormal_urinary_system0.53594345
118MP0005367_renal/urinary_system_phenotyp0.53594345
119MP0003283_abnormal_digestive_organ0.53290143
120MP0004130_abnormal_muscle_cell0.52123292
121MP0001299_abnormal_eye_distance/0.50458415
122MP0003938_abnormal_ear_development0.50279637

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.26192640
2Focal motor seizures (HP:0011153)6.17377187
3Myokymia (HP:0002411)5.93274991
4Central scotoma (HP:0000603)5.04922836
5Focal seizures (HP:0007359)4.64615175
6Bony spicule pigmentary retinopathy (HP:0007737)4.64250932
7Abnormal rod and cone electroretinograms (HP:0008323)4.57336547
8Epileptic encephalopathy (HP:0200134)4.53343197
9Visual hallucinations (HP:0002367)4.36854880
10Abnormality of macular pigmentation (HP:0008002)4.23724687
11Febrile seizures (HP:0002373)4.13836160
12Absent rod-and cone-mediated responses on ERG (HP:0007688)4.06633917
13Progressive cerebellar ataxia (HP:0002073)4.06106590
14Scotoma (HP:0000575)3.91656858
15Decreased central vision (HP:0007663)3.77525062
16Supranuclear gaze palsy (HP:0000605)3.41148875
17Ankle clonus (HP:0011448)3.38336620
18Action tremor (HP:0002345)3.34764436
19Absence seizures (HP:0002121)3.27092605
20Pendular nystagmus (HP:0012043)3.24432815
21Severe visual impairment (HP:0001141)3.23335179
22Atonic seizures (HP:0010819)3.09181002
23Chorioretinal atrophy (HP:0000533)3.05697045
24Dialeptic seizures (HP:0011146)3.01162302
25Genetic anticipation (HP:0003743)2.98213251
26Gaze-evoked nystagmus (HP:0000640)2.96821790
27Impaired vibration sensation in the lower limbs (HP:0002166)2.93083045
28Urinary bladder sphincter dysfunction (HP:0002839)2.92868558
29Abnormal ciliary motility (HP:0012262)2.92330016
30Broad-based gait (HP:0002136)2.89889285
31Generalized tonic-clonic seizures (HP:0002069)2.88329548
32Pigmentary retinal degeneration (HP:0001146)2.87767352
33Dysdiadochokinesis (HP:0002075)2.87457406
34Absent/shortened dynein arms (HP:0200106)2.84990697
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.84990697
36Dyschromatopsia (HP:0007641)2.84427640
37Abnormality of the lower motor neuron (HP:0002366)2.83073442
38Attenuation of retinal blood vessels (HP:0007843)2.80591460
39Abolished electroretinogram (ERG) (HP:0000550)2.80080656
40Depression (HP:0000716)2.79148700
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77028286
42Poor eye contact (HP:0000817)2.73589488
43Dysmetria (HP:0001310)2.73524542
44Abnormal respiratory epithelium morphology (HP:0012253)2.68476681
45Abnormal respiratory motile cilium morphology (HP:0005938)2.68476681
46Hepatoblastoma (HP:0002884)2.65507758
47Truncal ataxia (HP:0002078)2.63333928
48Hyperventilation (HP:0002883)2.62919129
49Spastic gait (HP:0002064)2.60954560
50Mutism (HP:0002300)2.58823335
51Akinesia (HP:0002304)2.56200892
52Polyphagia (HP:0002591)2.56095598
53Increased circulating renin level (HP:0000848)2.55714221
54Drooling (HP:0002307)2.55452325
55Excessive salivation (HP:0003781)2.55452325
56Macular degeneration (HP:0000608)2.54623788
57Abnormal respiratory motile cilium physiology (HP:0012261)2.54299587
58Abnormality of the corticospinal tract (HP:0002492)2.52397497
59Postural instability (HP:0002172)2.48086655
60Abnormal social behavior (HP:0012433)2.47304009
61Impaired social interactions (HP:0000735)2.47304009
62Photophobia (HP:0000613)2.46945041
63Choroideremia (HP:0001139)2.46714232
64Type II diabetes mellitus (HP:0005978)2.44735539
65Hemiparesis (HP:0001269)2.34242161
66Oligodactyly (hands) (HP:0001180)2.33729728
67Protruding tongue (HP:0010808)2.32973782
68Urinary urgency (HP:0000012)2.31450183
69Amblyopia (HP:0000646)2.31300382
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31155687
71Anxiety (HP:0000739)2.30668772
72Increased corneal curvature (HP:0100692)2.29697925
73Keratoconus (HP:0000563)2.29697925
74Sleep apnea (HP:0010535)2.25102829
75Neurofibrillary tangles (HP:0002185)2.23859524
76Absent speech (HP:0001344)2.23051083
77Peripheral hypomyelination (HP:0007182)2.22152794
78Intention tremor (HP:0002080)2.19836136
79Epileptiform EEG discharges (HP:0011182)2.19354328
80Lower limb muscle weakness (HP:0007340)2.17290423
81Rhinitis (HP:0012384)2.15684299
82Thickened helices (HP:0000391)2.15359187
83Torticollis (HP:0000473)2.13915338
84Abnormality of the labia minora (HP:0012880)2.13690019
85EEG with generalized epileptiform discharges (HP:0011198)2.13511026
86Progressive inability to walk (HP:0002505)2.12648615
87Hemiplegia (HP:0002301)2.10689278
88Alacrima (HP:0000522)2.10197798
89Cone-rod dystrophy (HP:0000548)2.09694710
90Impaired smooth pursuit (HP:0007772)2.09450229
91Scanning speech (HP:0002168)2.09167420
92Widely spaced teeth (HP:0000687)2.08039039
93Status epilepticus (HP:0002133)2.05968992
94Gait imbalance (HP:0002141)2.03525926
95Abnormality of ocular smooth pursuit (HP:0000617)2.01622968
96Focal dystonia (HP:0004373)1.99056460
97Stereotypic behavior (HP:0000733)1.98988592
98Hypsarrhythmia (HP:0002521)1.97889199
99Cerebral inclusion bodies (HP:0100314)1.96934515
100Insomnia (HP:0100785)1.94805574
101Abnormal eating behavior (HP:0100738)1.94677447
102Abnormality of binocular vision (HP:0011514)1.94383724
103Diplopia (HP:0000651)1.94383724
104Split foot (HP:0001839)1.93698459
105Clonus (HP:0002169)1.92992662
106Megalencephaly (HP:0001355)1.92840603
107Obstructive sleep apnea (HP:0002870)1.92697289
108Bradykinesia (HP:0002067)1.90808208
109Retinitis pigmentosa (HP:0000510)1.90550599
110Esotropia (HP:0000565)1.89805027
111Impaired vibratory sensation (HP:0002495)1.88310447
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85971763
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.85971763
114Hyperaldosteronism (HP:0000859)1.84741380
115Amyotrophic lateral sclerosis (HP:0007354)1.84449666
116Papilledema (HP:0001085)1.83849902
117Pointed chin (HP:0000307)1.83017451
118Septo-optic dysplasia (HP:0100842)1.82706932
119Abnormality of the periventricular white matter (HP:0002518)1.82641777
120Specific learning disability (HP:0001328)1.81845638
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81102791
122Spastic tetraplegia (HP:0002510)1.80881128
123Fetal akinesia sequence (HP:0001989)1.76506350
124Posterior subcapsular cataract (HP:0007787)1.75381756
125Retinal dysplasia (HP:0007973)1.75179370
126Prolonged QT interval (HP:0001657)1.73168772
127Limb dystonia (HP:0002451)1.72775810
128Hypoplasia of the corpus callosum (HP:0002079)1.72688261
129Ventricular fibrillation (HP:0001663)1.72112050
130Agitation (HP:0000713)1.72072657
131Nephronophthisis (HP:0000090)1.71749129
132Abnormal drinking behavior (HP:0030082)1.70841972
133Polydipsia (HP:0001959)1.70841972
134Cerebral hypomyelination (HP:0006808)1.69762824
135Decreased lacrimation (HP:0000633)1.69557518
136Generalized myoclonic seizures (HP:0002123)1.69138631
137Hypomagnesemia (HP:0002917)1.68595493
138Intellectual disability, severe (HP:0010864)1.66856521
139Gastroesophageal reflux (HP:0002020)1.64662261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.69666567
2NTRK34.14181409
3MARK14.03883523
4MAP3K93.12705043
5FRK2.84146040
6PAK62.64651719
7MAP3K42.57118134
8MINK12.26570535
9PRPF4B2.12429330
10NTRK22.09185349
11KSR22.07502928
12FGFR22.06057858
13MAP2K72.04754592
14DAPK22.01165244
15PRKD31.99105523
16KSR11.78185361
17SIK21.75733171
18CASK1.71820188
19CAMKK11.70994045
20TNIK1.58712125
21CDK51.53087799
22MAP3K131.43247571
23SGK2231.40992731
24SGK4941.40992731
25MAPK131.38401905
26STK381.38371101
27PHKG21.35734631
28PHKG11.35734631
29FES1.35425526
30MAP2K41.23019233
31NTRK11.21395151
32PKN11.12974598
33WNK31.12787179
34TYRO31.12390156
35RIPK41.10376359
36PRKCG1.03143122
37SGK21.02617879
38DYRK1A1.02210766
39GRK51.01859337
40PINK11.01286933
41PLK20.99738812
42CAMK10.99655561
43DYRK20.99345990
44GRK10.97419833
45CAMK2A0.97290218
46PAK30.96728380
47DAPK10.93296322
48STK110.92884944
49UHMK10.92762910
50ARAF0.91050665
51MAP3K20.90345883
52RAF10.89530532
53CAMK1G0.88477503
54MAPK150.87321371
55SGK10.86127990
56SGK30.85669130
57MAP3K70.84157024
58CDK150.82117565
59CDK180.81942834
60CAMK2B0.81394762
61ICK0.81321287
62BCR0.81075628
63CDK190.78753071
64PNCK0.77965031
65MARK20.77946897
66PRKCH0.77592097
67PRKCZ0.74834216
68CAMK40.73668554
69CDK140.73030775
70CDC42BPA0.70870880
71CDK11A0.69849661
72MAP4K20.69731067
73NEK60.67884073
74PTK2B0.65252416
75CAMKK20.64653577
76ERBB30.64508283
77BMPR20.63809622
78RET0.63699206
79TAOK10.63438466
80ALK0.62966202
81ROCK20.62577920
82MAPK120.59796365
83RPS6KA30.57956786
84ERBB20.56414117
85CSNK1G20.55540832
86CAMK2D0.54891650
87PRKCE0.54036830
88CSNK1D0.53118088
89EPHA30.52470355
90WNK10.51861859
91DMPK0.51778842
92RIPK10.51453731
93TAOK20.49948322
94MAPK100.49202888
95NME10.48760539
96CCNB10.48538886
97CSNK1A1L0.47903733
98CDK30.47106722
99PRKG10.45985060
100CSNK1A10.45721574
101MAP3K120.44355758
102OXSR10.44261862
103ROCK10.43927073
104TNK20.43527959
105PRKCB0.43066985
106FYN0.42395155
107MAPK80.41474342
108PDK10.41036819
109RPS6KA20.40945192
110GSK3B0.40865139
111INSRR0.40529829
112FER0.40076136
113MAP2K60.39758816
114CAMK1D0.39075825
115BRD40.38474324
116MAP3K10.38025168
117AKT30.37963388
118LMTK20.37754955
119CAMK2G0.37458248
120PRKAA10.37365367
121FGFR30.35934301
122RPS6KB10.34235667
123PRKACA0.33080627
124CSNK1G30.31416664
125PRKD10.29437258
126CSNK1G10.28842579
127CDK120.28192417

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.35430456
2Nicotine addiction_Homo sapiens_hsa050333.52773735
3Synaptic vesicle cycle_Homo sapiens_hsa047213.10143374
4Olfactory transduction_Homo sapiens_hsa047402.84450262
5GABAergic synapse_Homo sapiens_hsa047272.80398792
6Circadian entrainment_Homo sapiens_hsa047132.67773320
7Glutamatergic synapse_Homo sapiens_hsa047242.61183464
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59641162
9Morphine addiction_Homo sapiens_hsa050322.51017579
10Long-term potentiation_Homo sapiens_hsa047202.23382401
11Amphetamine addiction_Homo sapiens_hsa050312.01273787
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00107740
13Cholinergic synapse_Homo sapiens_hsa047251.96231801
14Dopaminergic synapse_Homo sapiens_hsa047281.91728439
15Salivary secretion_Homo sapiens_hsa049701.89085737
16Insulin secretion_Homo sapiens_hsa049111.80923831
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68041397
18Oxytocin signaling pathway_Homo sapiens_hsa049211.63318337
19Serotonergic synapse_Homo sapiens_hsa047261.62459904
20Gastric acid secretion_Homo sapiens_hsa049711.62402444
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49012934
22Taste transduction_Homo sapiens_hsa047421.48999361
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47287300
24Renin secretion_Homo sapiens_hsa049241.46005371
25Long-term depression_Homo sapiens_hsa047301.45347329
26Cocaine addiction_Homo sapiens_hsa050301.44134061
27Calcium signaling pathway_Homo sapiens_hsa040201.38607634
28GnRH signaling pathway_Homo sapiens_hsa049121.32530575
29Axon guidance_Homo sapiens_hsa043601.30083938
30Type II diabetes mellitus_Homo sapiens_hsa049301.28376816
31cAMP signaling pathway_Homo sapiens_hsa040241.26372852
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15943137
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14302161
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11173684
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10720538
36Gap junction_Homo sapiens_hsa045401.08728010
37ErbB signaling pathway_Homo sapiens_hsa040121.06359985
38Glioma_Homo sapiens_hsa052141.03677087
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02691952
40ABC transporters_Homo sapiens_hsa020101.02033447
41Histidine metabolism_Homo sapiens_hsa003400.97509886
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94049937
43Estrogen signaling pathway_Homo sapiens_hsa049150.94048238
44Vitamin B6 metabolism_Homo sapiens_hsa007500.90797801
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90706299
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.90149643
47Butanoate metabolism_Homo sapiens_hsa006500.89564702
48beta-Alanine metabolism_Homo sapiens_hsa004100.89366162
49Melanogenesis_Homo sapiens_hsa049160.87856705
50Collecting duct acid secretion_Homo sapiens_hsa049660.87454922
51Choline metabolism in cancer_Homo sapiens_hsa052310.83779550
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.83366059
53MAPK signaling pathway_Homo sapiens_hsa040100.83287358
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80551208
55Dilated cardiomyopathy_Homo sapiens_hsa054140.78935548
56Dorso-ventral axis formation_Homo sapiens_hsa043200.77408537
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75308172
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74891156
59Nitrogen metabolism_Homo sapiens_hsa009100.72509516
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71385732
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70196953
62Cardiac muscle contraction_Homo sapiens_hsa042600.68949946
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.68519601
64Pancreatic secretion_Homo sapiens_hsa049720.67087883
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65482660
66Ras signaling pathway_Homo sapiens_hsa040140.64927042
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64209757
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62282563
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61982674
70Circadian rhythm_Homo sapiens_hsa047100.61867164
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61589047
72Chemokine signaling pathway_Homo sapiens_hsa040620.60361203
73Type I diabetes mellitus_Homo sapiens_hsa049400.59351441
74Sphingolipid metabolism_Homo sapiens_hsa006000.58388889
75Endometrial cancer_Homo sapiens_hsa052130.55979359
76VEGF signaling pathway_Homo sapiens_hsa043700.55460337
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55036973
78mTOR signaling pathway_Homo sapiens_hsa041500.54953580
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54780453
80Oocyte meiosis_Homo sapiens_hsa041140.54463705
81Thyroid hormone synthesis_Homo sapiens_hsa049180.54236791
82Vibrio cholerae infection_Homo sapiens_hsa051100.52559728
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.51732024
84Endocytosis_Homo sapiens_hsa041440.51307626
85Inositol phosphate metabolism_Homo sapiens_hsa005620.51060301
86Rap1 signaling pathway_Homo sapiens_hsa040150.49760858
87Renal cell carcinoma_Homo sapiens_hsa052110.49555311
88Tight junction_Homo sapiens_hsa045300.49039962
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48547178
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.43860479
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43179170
92Wnt signaling pathway_Homo sapiens_hsa043100.43127303
93Non-small cell lung cancer_Homo sapiens_hsa052230.42996658
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42917901
95Ether lipid metabolism_Homo sapiens_hsa005650.42221782
96Alcoholism_Homo sapiens_hsa050340.42186251
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42035849
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42003159
99Ovarian steroidogenesis_Homo sapiens_hsa049130.41886438
100AMPK signaling pathway_Homo sapiens_hsa041520.39832750
101African trypanosomiasis_Homo sapiens_hsa051430.39270296
102Hippo signaling pathway_Homo sapiens_hsa043900.38802024
103Notch signaling pathway_Homo sapiens_hsa043300.38395329
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37931677
105Colorectal cancer_Homo sapiens_hsa052100.36482777
106Bile secretion_Homo sapiens_hsa049760.35225204
107Glucagon signaling pathway_Homo sapiens_hsa049220.33961675
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33597929
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32939785
110Prion diseases_Homo sapiens_hsa050200.31339466
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26219421
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25920567
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25435676
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.25047830
115Insulin signaling pathway_Homo sapiens_hsa049100.24877470

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