DSCR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene is found in a region of chromosome 21 that has been linked to the pathogenesis of Down syndrome. This gene is transcribed from a bi-directional promoter located in an endogenous retrovirus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.08601873
2synapsis (GO:0007129)5.93566182
3DNA replication checkpoint (GO:0000076)5.88800090
4nuclear pore organization (GO:0006999)5.58812503
5DNA replication initiation (GO:0006270)4.79107179
6resolution of meiotic recombination intermediates (GO:0000712)4.77254216
7regulation of translational fidelity (GO:0006450)4.69656903
8diterpenoid biosynthetic process (GO:0016102)4.59587919
9pore complex assembly (GO:0046931)4.57684566
10regulation of histone H3-K4 methylation (GO:0051569)4.47066453
11DNA topological change (GO:0006265)4.46115735
12formation of translation preinitiation complex (GO:0001731)4.35888636
13mitotic nuclear envelope disassembly (GO:0007077)4.35837911
14DNA methylation involved in gamete generation (GO:0043046)4.35033728
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.31237631
16DNA strand elongation involved in DNA replication (GO:0006271)4.25805152
17mitotic sister chromatid segregation (GO:0000070)4.22880699
18protoporphyrinogen IX metabolic process (GO:0046501)4.22256717
19sister chromatid segregation (GO:0000819)4.16532714
20DNA unwinding involved in DNA replication (GO:0006268)4.12758004
21DNA strand elongation (GO:0022616)4.12411326
22nuclear envelope disassembly (GO:0051081)4.05798741
23membrane disassembly (GO:0030397)4.05798741
24terpenoid biosynthetic process (GO:0016114)4.03034127
25telomere maintenance via semi-conservative replication (GO:0032201)3.99103325
26mitotic chromosome condensation (GO:0007076)3.98440097
27DNA synthesis involved in DNA repair (GO:0000731)3.95669621
28purine nucleobase biosynthetic process (GO:0009113)3.95341720
29meiotic chromosome segregation (GO:0045132)3.88981306
30regulation of RNA export from nucleus (GO:0046831)3.86894075
31chromosome organization involved in meiosis (GO:0070192)3.86515537
32protoporphyrinogen IX biosynthetic process (GO:0006782)3.83928445
33tRNA aminoacylation for protein translation (GO:0006418)3.75542825
34oxidative phosphorylation (GO:0006119)3.74300269
35tRNA aminoacylation (GO:0043039)3.63738873
36amino acid activation (GO:0043038)3.63738873
37tetrahydrofolate metabolic process (GO:0046653)3.59622916
38gas transport (GO:0015669)3.56499435
39chromosome segregation (GO:0007059)3.55041413
40telomere maintenance via recombination (GO:0000722)3.50490373
41mitotic recombination (GO:0006312)3.47993866
42mitotic metaphase plate congression (GO:0007080)3.47047578
43vitamin A metabolic process (GO:0006776)3.45790344
44protein localization to kinetochore (GO:0034501)3.45715532
45regulation of histone H3-K27 methylation (GO:0061085)3.45570233
46folic acid-containing compound biosynthetic process (GO:0009396)3.43007191
47homocysteine metabolic process (GO:0050667)3.38472569
48oxygen transport (GO:0015671)3.37743072
49male meiosis I (GO:0007141)3.37314424
50protein localization to chromosome, centromeric region (GO:0071459)3.37146821
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35324121
52nucleobase biosynthetic process (GO:0046112)3.34476733
53proteasome assembly (GO:0043248)3.34349904
54kinetochore organization (GO:0051383)3.29971068
55regulation of histone methylation (GO:0031060)3.28142470
56microtubule depolymerization (GO:0007019)3.25882232
57positive regulation of histone H3-K4 methylation (GO:0051571)3.25292819
58gonadal mesoderm development (GO:0007506)3.23073849
59proline biosynthetic process (GO:0006561)3.21186808
60oxaloacetate metabolic process (GO:0006107)3.19405488
61intra-S DNA damage checkpoint (GO:0031573)3.17092933
62regulation of histone H3-K9 methylation (GO:0051570)3.16925226
63male meiosis (GO:0007140)3.16906449
64centriole replication (GO:0007099)3.16606248
65negative regulation of histone methylation (GO:0031061)3.12493001
66regulation of meiosis I (GO:0060631)3.06240816
67CENP-A containing nucleosome assembly (GO:0034080)3.05474099
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03918050
69regulation of mitotic spindle organization (GO:0060236)3.01400336
70ribosomal large subunit biogenesis (GO:0042273)3.00843189
71regulation of nucleobase-containing compound transport (GO:0032239)2.98323483
72meiosis I (GO:0007127)2.97485684
73response to vitamin A (GO:0033189)2.96647912
74IMP biosynthetic process (GO:0006188)2.96329620
75regulation of double-strand break repair via homologous recombination (GO:0010569)2.95600619
76regulation of DNA methylation (GO:0044030)2.94525909
77metaphase plate congression (GO:0051310)2.93881439
78negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.92870115
79aerobic respiration (GO:0009060)2.92648147
80sensory perception of smell (GO:0007608)2.92520951
81regulation of translational elongation (GO:0006448)2.91502214
82erythrocyte maturation (GO:0043249)2.89047823
83kinetochore assembly (GO:0051382)2.87877980
84chromosome condensation (GO:0030261)2.87740839
85nuclear envelope organization (GO:0006998)2.86307838
86piRNA metabolic process (GO:0034587)2.84578428
87DNA packaging (GO:0006323)2.82714867
88ribosomal small subunit assembly (GO:0000028)2.82153906
89positive regulation of histone methylation (GO:0031062)2.81996741
90telomere maintenance via telomere lengthening (GO:0010833)2.81002750
91ribosome biogenesis (GO:0042254)2.80901998
92meiotic cell cycle process (GO:1903046)2.78007051
93mitotic G2/M transition checkpoint (GO:0044818)2.77543705
94regulation of centriole replication (GO:0046599)2.77377536
95definitive hemopoiesis (GO:0060216)2.77050928
96DNA replication-independent nucleosome organization (GO:0034724)2.76902509
97DNA replication-independent nucleosome assembly (GO:0006336)2.76902509
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.75569624
99mismatch repair (GO:0006298)2.75278984
100regulation of centrosome cycle (GO:0046605)2.74551122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.94515707
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.82061569
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81888129
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79842134
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31843299
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.30026346
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16263993
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02643494
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01864216
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85970119
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.79204860
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.78283171
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73879656
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.73434647
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66966085
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54129654
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.53863916
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47112070
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.39902327
20NCOR1_26117541_ChIP-Seq_K562_Human2.39275439
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27853276
22XRN2_22483619_ChIP-Seq_HELA_Human2.25831214
23DCP1A_22483619_ChIP-Seq_HELA_Human2.17548467
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09097474
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02289051
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00795027
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00559990
28TTF2_22483619_ChIP-Seq_HELA_Human1.96037609
29ELK1_19687146_ChIP-ChIP_HELA_Human1.90164505
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88315674
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84867723
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.83868814
33GATA1_19941826_ChIP-Seq_K562_Human1.82042784
34FOXP3_21729870_ChIP-Seq_TREG_Human1.81833099
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80623101
36ZNF263_19887448_ChIP-Seq_K562_Human1.79338041
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.77689113
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77603364
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77592979
40AR_21909140_ChIP-Seq_LNCAP_Human1.75905741
41VDR_23849224_ChIP-Seq_CD4+_Human1.73799591
42GABP_19822575_ChIP-Seq_HepG2_Human1.72143105
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71777759
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71656771
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70758402
46KDM5A_27292631_Chip-Seq_BREAST_Human1.66510208
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62356132
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45293349
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43687810
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43244251
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40249137
52GATA1_22025678_ChIP-Seq_K562_Human1.37980056
53GATA2_19941826_ChIP-Seq_K562_Human1.33404799
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.33158808
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32928836
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31441974
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30474541
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30110593
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29703651
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28698521
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23344997
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23025732
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22636378
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21771432
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21547931
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20589504
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19449318
68CIITA_25753668_ChIP-Seq_RAJI_Human1.10320741
69SCL_19346495_ChIP-Seq_HPC-7_Human1.09074066
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08986467
71TFEB_21752829_ChIP-Seq_HELA_Human1.08358757
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06336866
73SPI1_23127762_ChIP-Seq_K562_Human1.01652224
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01428465
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00914591
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.00909326
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00449070
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97790619
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97102148
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95083819
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93841056
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90981540
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88823601
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87573525
85VDR_22108803_ChIP-Seq_LS180_Human0.86299432
86MYC_18940864_ChIP-ChIP_HL60_Human0.86276799
87TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85950799
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83348649
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82850945
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81194260
91GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80946897
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78058128
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77848721
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.75847196
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75450326
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75277676
97PHF8_20622853_ChIP-Seq_HELA_Human0.74701411
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.73847622
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73814954
100MYC_22102868_ChIP-Seq_BL_Human0.73089120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence4.17907493
2MP0008058_abnormal_DNA_repair4.02756666
3MP0010094_abnormal_chromosome_stability3.80067538
4MP0004147_increased_porphyrin_level3.78730508
5MP0004957_abnormal_blastocyst_morpholog3.76538540
6MP0003111_abnormal_nucleus_morphology3.58044644
7MP0003718_maternal_effect3.33607906
8MP0009697_abnormal_copulation3.28658671
9MP0003693_abnormal_embryo_hatching3.27488227
10MP0005451_abnormal_body_composition3.05375147
11MP0000678_abnormal_parathyroid_gland3.03998301
12MP0008932_abnormal_embryonic_tissue2.95745583
13MP0008057_abnormal_DNA_replication2.91627921
14MP0003077_abnormal_cell_cycle2.73764196
15MP0003786_premature_aging2.63857700
16MP0005083_abnormal_biliary_tract2.23798703
17MP0002210_abnormal_sex_determination2.12405797
18MP0003656_abnormal_erythrocyte_physiolo2.10603613
19MP0001929_abnormal_gametogenesis2.01908952
20MP0003186_abnormal_redox_activity1.90423750
21MP0006036_abnormal_mitochondrial_physio1.82546094
22MP0001730_embryonic_growth_arrest1.79892449
23MP0008007_abnormal_cellular_replicative1.79368266
24MP0006035_abnormal_mitochondrial_morpho1.74631010
25MP0002132_abnormal_respiratory_system1.72147930
26MP0001545_abnormal_hematopoietic_system1.70146576
27MP0005397_hematopoietic_system_phenotyp1.70146576
28MP0000372_irregular_coat_pigmentation1.68802441
29MP0010307_abnormal_tumor_latency1.66543398
30MP0005410_abnormal_fertilization1.66347865
31MP0000350_abnormal_cell_proliferation1.65612523
32MP0003806_abnormal_nucleotide_metabolis1.61506228
33MP0001697_abnormal_embryo_size1.57804646
34MP0008877_abnormal_DNA_methylation1.51432092
35MP0004233_abnormal_muscle_weight1.51347028
36MP0003698_abnormal_male_reproductive1.49757721
37MP0001145_abnormal_male_reproductive1.49315710
38MP0000653_abnormal_sex_gland1.46963962
39MP0005380_embryogenesis_phenotype1.43897052
40MP0001672_abnormal_embryogenesis/_devel1.43897052
41MP0008775_abnormal_heart_ventricle1.42116949
42MP0000313_abnormal_cell_death1.39896880
43MP0002080_prenatal_lethality1.36417506
44MP0004145_abnormal_muscle_electrophysio1.31899536
45MP0003984_embryonic_growth_retardation1.28674596
46MP0003699_abnormal_female_reproductive1.27237247
47MP0000358_abnormal_cell_content/1.26053567
48MP0005408_hypopigmentation1.25496931
49MP0005636_abnormal_mineral_homeostasis1.24769151
50MP0002088_abnormal_embryonic_growth/wei1.23030801
51MP0002396_abnormal_hematopoietic_system1.19018488
52MP0002161_abnormal_fertility/fecundity1.16536351
53MP0002139_abnormal_hepatobiliary_system1.16430500
54MP0002086_abnormal_extraembryonic_tissu1.15197468
55MP0004084_abnormal_cardiac_muscle1.13054297
56MP0006292_abnormal_olfactory_placode1.08825899
57MP0001661_extended_life_span1.07870984
58MP0003959_abnormal_lean_body1.02276902
59MP0003890_abnormal_embryonic-extraembry1.02116617
60MP0003950_abnormal_plasma_membrane1.02025336
61MP0005395_other_phenotype1.01020034
62MP0002269_muscular_atrophy0.97192122
63MP0005076_abnormal_cell_differentiation0.97015597
64MP0004019_abnormal_vitamin_homeostasis0.96898784
65MP0001881_abnormal_mammary_gland0.96827864
66MP0002084_abnormal_developmental_patter0.94231949
67MP0005171_absent_coat_pigmentation0.93137498
68MP0001764_abnormal_homeostasis0.92309263
69MP0002085_abnormal_embryonic_tissue0.89752010
70MP0001119_abnormal_female_reproductive0.87971505
71MP0002019_abnormal_tumor_incidence0.87587673
72MP0005647_abnormal_sex_gland0.86698723
73MP0005332_abnormal_amino_acid0.84554640
74MP0000647_abnormal_sebaceous_gland0.79465240
75MP0001727_abnormal_embryo_implantation0.79004507
76MP0004808_abnormal_hematopoietic_stem0.75665584
77MP0001502_abnormal_circadian_rhythm0.73911105
78MP0000609_abnormal_liver_physiology0.73359974
79MP0003941_abnormal_skin_development0.71586136
80MP0003646_muscle_fatigue0.71035167
81MP0008770_decreased_survivor_rate0.70378933
82MP0002160_abnormal_reproductive_system0.68588372
83MP0001529_abnormal_vocalization0.68538140
84MP0009333_abnormal_splenocyte_physiolog0.67935651
85MP0000703_abnormal_thymus_morphology0.65530945
86MP0002249_abnormal_larynx_morphology0.63580340
87MP0004036_abnormal_muscle_relaxation0.63061595
88MP0005389_reproductive_system_phenotype0.62785306
89MP0003567_abnormal_fetal_cardiomyocyte0.62766141
90MP0003385_abnormal_body_wall0.62626808
91MP0000598_abnormal_liver_morphology0.61148405
92MP0000747_muscle_weakness0.60827540
93MP0004197_abnormal_fetal_growth/weight/0.60140686
94MP0005384_cellular_phenotype0.59789553
95MP0003221_abnormal_cardiomyocyte_apopto0.57809122
96MP0009115_abnormal_fat_cell0.57702333
97MP0000681_abnormal_thyroid_gland0.57489656
98MP0005646_abnormal_pituitary_gland0.57042550
99MP0003936_abnormal_reproductive_system0.56897939
100MP0001919_abnormal_reproductive_system0.56547385

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)7.09617395
2Cholecystitis (HP:0001082)7.09617395
3Truncus arteriosus (HP:0001660)5.54497325
4Hyperthyroidism (HP:0000836)4.95467071
5Reticulocytosis (HP:0001923)4.57402115
6Birth length less than 3rd percentile (HP:0003561)4.56018696
7Chromsome breakage (HP:0040012)4.32507136
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30286366
9Polycythemia (HP:0001901)4.21741653
10Increased serum pyruvate (HP:0003542)3.95767289
11Abnormality of glycolysis (HP:0004366)3.94743129
12Abnormality of reticulocytes (HP:0004312)3.93630516
13Upper limb muscle weakness (HP:0003484)3.80321556
14Bowel incontinence (HP:0002607)3.67133532
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.64773878
16Abnormal large intestine physiology (HP:0012700)3.59594412
17Seborrheic dermatitis (HP:0001051)3.50454665
18Hypertensive crisis (HP:0100735)3.47669341
19Cortical dysplasia (HP:0002539)3.44864939
20Abnormal hemoglobin (HP:0011902)3.35221041
21Ankyloglossia (HP:0010296)3.28997908
22Cholelithiasis (HP:0001081)3.28702473
23Ileus (HP:0002595)3.21429491
24Abnormality of cochlea (HP:0000375)3.17796011
25Abnormality of homocysteine metabolism (HP:0010919)3.11665818
26Homocystinuria (HP:0002156)3.11665818
27Hypoparathyroidism (HP:0000829)3.11065134
28Abnormality of the tricuspid valve (HP:0001702)2.91422056
29Pallor (HP:0000980)2.91292285
30Abnormal gallbladder morphology (HP:0012437)2.91140661
31Aplasia/Hypoplasia of the earlobes (HP:0009906)2.84759577
32Acute myeloid leukemia (HP:0004808)2.73855178
33Atelectasis (HP:0100750)2.72235662
34Poikilocytosis (HP:0004447)2.63546375
35Duplicated collecting system (HP:0000081)2.61671719
36Reticulocytopenia (HP:0001896)2.59001583
37Abnormality of the preputium (HP:0100587)2.53377541
38Acute necrotizing encephalopathy (HP:0006965)2.47102561
39Duodenal stenosis (HP:0100867)2.46126924
40Small intestinal stenosis (HP:0012848)2.46126924
41Acute encephalopathy (HP:0006846)2.45665514
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.44023181
43Abnormal mitochondria in muscle tissue (HP:0008316)2.43258309
44Morphological abnormality of the inner ear (HP:0011390)2.37482346
45Myelodysplasia (HP:0002863)2.35279907
46Abnormality of the gallbladder (HP:0005264)2.35204611
47Abnormality of the renal collecting system (HP:0004742)2.31024459
48Abnormality of chromosome stability (HP:0003220)2.29928241
49Short middle phalanx of the 5th finger (HP:0004220)2.29422885
50Abnormality of DNA repair (HP:0003254)2.24022786
51Nonimmune hydrops fetalis (HP:0001790)2.22824908
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.21786042
53Hyperbilirubinemia (HP:0002904)2.19077321
54Acanthocytosis (HP:0001927)2.17759220
55Increased CSF lactate (HP:0002490)2.17255699
56Breech presentation (HP:0001623)2.16489594
57Tinnitus (HP:0000360)2.12099681
58Premature ovarian failure (HP:0008209)2.10401863
59Respiratory difficulties (HP:0002880)2.08788582
60Abnormality of oral frenula (HP:0000190)2.08688162
61Secondary amenorrhea (HP:0000869)2.06089067
62Overlapping toe (HP:0001845)2.05938061
63Progressive macrocephaly (HP:0004481)2.03502856
64Macrocytic anemia (HP:0001972)2.02600371
65Abnormally folded helix (HP:0008544)2.00690017
66Abnormality of cells of the erythroid lineage (HP:0012130)1.99037245
67Increased nuchal translucency (HP:0010880)1.95125013
68Aplasia/Hypoplasia of the thymus (HP:0010515)1.94823840
69Increased serum lactate (HP:0002151)1.89637073
70Meckel diverticulum (HP:0002245)1.89391999
71Male infertility (HP:0003251)1.88973962
72Increased hepatocellular lipid droplets (HP:0006565)1.88701098
73Lipid accumulation in hepatocytes (HP:0006561)1.85571021
74Sandal gap (HP:0001852)1.85108598
75Breast hypoplasia (HP:0003187)1.84147611
76Peripheral hypomyelination (HP:0007182)1.83758572
77Abnormality of the duodenum (HP:0002246)1.82337498
78Cheekbone underdevelopment (HP:0010669)1.80207414
79Abnormality of the pons (HP:0007361)1.79918420
80Abnormality of the ileum (HP:0001549)1.78489954
81Mitochondrial inheritance (HP:0001427)1.78028187
82Orthostatic hypotension (HP:0001278)1.77671435
83Adenoma sebaceum (HP:0009720)1.76816577
84Angiofibromas (HP:0010615)1.76816577
85Redundant skin (HP:0001582)1.76507454
86Septate vagina (HP:0001153)1.73871590
87Cerebral hypomyelination (HP:0006808)1.73466187
88Cortical visual impairment (HP:0100704)1.73387027
89Abnormal lung lobation (HP:0002101)1.72979867
90Hepatic necrosis (HP:0002605)1.72589121
91Cerebral edema (HP:0002181)1.72582515
92Abnormal number of erythroid precursors (HP:0012131)1.72537447
93Aplastic anemia (HP:0001915)1.71535388
94Abnormality of the carotid arteries (HP:0005344)1.70634223
95Flat cornea (HP:0007720)1.70521025
96Hypoplasia of the pons (HP:0012110)1.68932806
97Ureteral duplication (HP:0000073)1.67909129
98Overfolded helix (HP:0000396)1.67041827
99Patellar dislocation (HP:0002999)1.65905906
100Cafe-au-lait spot (HP:0000957)1.64676940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.32536201
2TTK4.05358290
3RIPK43.48714641
4PBK3.47392467
5KSR23.26326059
6CLK13.09352004
7PLK42.71087455
8CDC72.50911278
9NME12.44888351
10PDK22.41575209
11RAF12.28949717
12BMPR22.27111692
13NTRK32.24794517
14BUB12.22722757
15EIF2AK32.21115066
16WEE12.20585906
17CCNB12.14564644
18EEF2K2.11207331
19MST42.08898899
20MAP3K22.04053144
21BRSK21.98519080
22KSR11.94892584
23NEK11.83079083
24MAP3K81.65849283
25SRPK11.59150675
26CHEK21.49990389
27TSSK61.40624021
28TAOK31.33623033
29NEK21.31553020
30BRAF1.27152859
31BRSK11.21876822
32NME21.18066701
33ATR1.17131747
34ICK1.16960357
35STK41.16579345
36RPS6KB21.15362646
37BMX1.14169036
38IRAK31.12021649
39WNK41.10645380
40CHEK11.08316862
41PLK11.06086315
42STK31.05381749
43PLK31.03972430
44MAP3K41.00412925
45CDK120.95100001
46PIK3CG0.88566240
47ALK0.86845534
48SCYL20.86795130
49CDK10.85008436
50ATM0.82765789
51TRPM70.77202898
52CDK20.76355184
53TNIK0.74835515
54PAK10.74326088
55MARK30.74084757
56MAP3K10.67381172
57PIM10.66576607
58AURKB0.65815039
59AURKA0.62288246
60MAP2K10.61656512
61ARAF0.60751843
62JAK20.60630791
63CSNK2A20.59535668
64MAP3K130.56664047
65ZAK0.56599040
66INSRR0.55000715
67RET0.51389822
68CDK70.50063745
69CSNK1E0.49873767
70PLK20.48917790
71CSNK2A10.46233667
72EIF2AK20.44485997
73PNCK0.42084435
74ILK0.41838728
75AKT30.40052682
76WNK10.38699231
77MATK0.36459671
78LRRK20.35902554
79STK100.35355249
80TEC0.34872510
81RPS6KA50.34401974
82GSK3B0.34308124
83MAPKAPK30.33865688
84AKT20.33623724
85MTOR0.33445710
86MAPKAPK50.31132825
87NEK60.31105625
88MAPK100.30447966
89MKNK10.29828075
90MAPK140.28593908
91PRKDC0.26762099
92DYRK30.25844514
93CDK11A0.25497961
94LATS10.23577207
95PRKCI0.23440332
96MAP3K60.22085687
97TAOK20.21713539
98CDK150.20945905
99CDK180.20860315
100MAPK130.19696887

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.97844420
2DNA replication_Homo sapiens_hsa030303.66789291
3Mismatch repair_Homo sapiens_hsa034303.57348473
4One carbon pool by folate_Homo sapiens_hsa006703.43618433
5Homologous recombination_Homo sapiens_hsa034403.38547516
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.84513935
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53831954
8Ribosome_Homo sapiens_hsa030102.49271421
9RNA transport_Homo sapiens_hsa030132.39827696
10Basal transcription factors_Homo sapiens_hsa030222.39623382
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38300772
12Cell cycle_Homo sapiens_hsa041102.34437492
13Nucleotide excision repair_Homo sapiens_hsa034202.27437542
14Fanconi anemia pathway_Homo sapiens_hsa034602.14765526
15Spliceosome_Homo sapiens_hsa030402.05468132
16Oxidative phosphorylation_Homo sapiens_hsa001902.03284296
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97714575
18Parkinsons disease_Homo sapiens_hsa050121.92003566
19Pyruvate metabolism_Homo sapiens_hsa006201.90792630
20RNA polymerase_Homo sapiens_hsa030201.85770428
21Steroid biosynthesis_Homo sapiens_hsa001001.78457071
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.74034232
23Proteasome_Homo sapiens_hsa030501.68566253
24Base excision repair_Homo sapiens_hsa034101.62682081
25Biosynthesis of amino acids_Homo sapiens_hsa012301.61106234
26Huntingtons disease_Homo sapiens_hsa050161.55266919
27Carbon metabolism_Homo sapiens_hsa012001.52507666
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.45800364
29RNA degradation_Homo sapiens_hsa030181.44349171
30mRNA surveillance pathway_Homo sapiens_hsa030151.26417066
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23958448
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18907408
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18549944
34Non-homologous end-joining_Homo sapiens_hsa034501.16627257
35Pyrimidine metabolism_Homo sapiens_hsa002401.14194428
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12750900
37Oocyte meiosis_Homo sapiens_hsa041141.12022894
38Selenocompound metabolism_Homo sapiens_hsa004501.09846783
39Olfactory transduction_Homo sapiens_hsa047401.05876118
40Fructose and mannose metabolism_Homo sapiens_hsa000511.00903353
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99703183
42Alzheimers disease_Homo sapiens_hsa050100.99684403
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96514399
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96302739
45Pentose phosphate pathway_Homo sapiens_hsa000300.96042430
46Acute myeloid leukemia_Homo sapiens_hsa052210.95569339
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.94638646
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94511144
49Arginine biosynthesis_Homo sapiens_hsa002200.91449284
50Propanoate metabolism_Homo sapiens_hsa006400.90726838
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89032484
52Purine metabolism_Homo sapiens_hsa002300.84660185
53Protein export_Homo sapiens_hsa030600.83716061
54Fatty acid elongation_Homo sapiens_hsa000620.82695494
55Folate biosynthesis_Homo sapiens_hsa007900.81248595
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76897688
57Fatty acid metabolism_Homo sapiens_hsa012120.75068120
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71991829
59Sulfur relay system_Homo sapiens_hsa041220.71241161
60Butanoate metabolism_Homo sapiens_hsa006500.67463472
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66365583
62HIF-1 signaling pathway_Homo sapiens_hsa040660.60889495
63Metabolic pathways_Homo sapiens_hsa011000.60799446
64Cardiac muscle contraction_Homo sapiens_hsa042600.59623447
65Thyroid cancer_Homo sapiens_hsa052160.55779793
66Type II diabetes mellitus_Homo sapiens_hsa049300.53804072
67Glutathione metabolism_Homo sapiens_hsa004800.53804059
68Viral carcinogenesis_Homo sapiens_hsa052030.53080819
69N-Glycan biosynthesis_Homo sapiens_hsa005100.51407149
70Arginine and proline metabolism_Homo sapiens_hsa003300.49635029
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48447876
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.48059817
73Chronic myeloid leukemia_Homo sapiens_hsa052200.47055162
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47020727
75Fatty acid biosynthesis_Homo sapiens_hsa000610.46414779
76mTOR signaling pathway_Homo sapiens_hsa041500.45443724
77Collecting duct acid secretion_Homo sapiens_hsa049660.42160695
78Vitamin B6 metabolism_Homo sapiens_hsa007500.37699338
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36784707
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.35540960
81Epstein-Barr virus infection_Homo sapiens_hsa051690.34575236
82Pancreatic cancer_Homo sapiens_hsa052120.32929628
83Synaptic vesicle cycle_Homo sapiens_hsa047210.31692788
84ErbB signaling pathway_Homo sapiens_hsa040120.31681181
85Renal cell carcinoma_Homo sapiens_hsa052110.29001487
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27364592
87Non-small cell lung cancer_Homo sapiens_hsa052230.25730241
88Inositol phosphate metabolism_Homo sapiens_hsa005620.22537252
89Lysine degradation_Homo sapiens_hsa003100.20663264
90Insulin signaling pathway_Homo sapiens_hsa049100.20447068
91VEGF signaling pathway_Homo sapiens_hsa043700.20168828
92MicroRNAs in cancer_Homo sapiens_hsa052060.19979828
93p53 signaling pathway_Homo sapiens_hsa041150.19771552
94Prion diseases_Homo sapiens_hsa050200.19589011
95Prolactin signaling pathway_Homo sapiens_hsa049170.11659716
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.10875261
97Hepatitis B_Homo sapiens_hsa051610.09971461
98Nicotine addiction_Homo sapiens_hsa050330.08970307
99Galactose metabolism_Homo sapiens_hsa000520.07111898
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06107831

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »