DSCR8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.05120726
2nuclear pore complex assembly (GO:0051292)5.45060564
3nuclear pore organization (GO:0006999)5.08711121
4DNA replication checkpoint (GO:0000076)5.01654805
5DNA methylation involved in gamete generation (GO:0043046)4.89232940
6regulation of meiosis I (GO:0060631)4.65863354
7resolution of meiotic recombination intermediates (GO:0000712)4.60833444
8proteasome assembly (GO:0043248)4.48519187
9piRNA metabolic process (GO:0034587)4.47585444
10gonadal mesoderm development (GO:0007506)4.27520287
11DNA replication initiation (GO:0006270)4.22936963
12regulation of translational fidelity (GO:0006450)4.20769667
13formation of translation preinitiation complex (GO:0001731)4.20251721
14gas transport (GO:0015669)4.15785919
15pore complex assembly (GO:0046931)4.04819397
16terpenoid biosynthetic process (GO:0016114)4.03676735
17mitotic nuclear envelope disassembly (GO:0007077)3.94604733
18chromosome organization involved in meiosis (GO:0070192)3.93376506
19telomere maintenance via semi-conservative replication (GO:0032201)3.86572388
20meiotic chromosome segregation (GO:0045132)3.85868845
21DNA strand elongation involved in DNA replication (GO:0006271)3.81452704
22protoporphyrinogen IX metabolic process (GO:0046501)3.78071034
23regulation of histone H3-K4 methylation (GO:0051569)3.76539462
24DNA strand elongation (GO:0022616)3.71901894
25male meiosis (GO:0007140)3.70466178
26mitotic chromosome condensation (GO:0007076)3.67205238
27membrane disassembly (GO:0030397)3.66690969
28nuclear envelope disassembly (GO:0051081)3.66690969
29oxygen transport (GO:0015671)3.65584695
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.64557866
31male meiosis I (GO:0007141)3.63762315
32mitotic metaphase plate congression (GO:0007080)3.59404376
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53509969
34mitotic sister chromatid segregation (GO:0000070)3.49875933
35oxidative phosphorylation (GO:0006119)3.48951046
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45501015
37diterpenoid biosynthetic process (GO:0016102)3.43221333
38tRNA aminoacylation for protein translation (GO:0006418)3.40420647
39telomere maintenance via recombination (GO:0000722)3.36129407
40rRNA methylation (GO:0031167)3.33380352
41rRNA modification (GO:0000154)3.30178706
42protoporphyrinogen IX biosynthetic process (GO:0006782)3.28670044
43amino acid activation (GO:0043038)3.28502001
44tRNA aminoacylation (GO:0043039)3.28502001
45protein localization to chromosome, centromeric region (GO:0071459)3.25879250
46protein localization to kinetochore (GO:0034501)3.25337208
47CENP-A containing nucleosome assembly (GO:0034080)3.25171595
48sister chromatid segregation (GO:0000819)3.25056724
49chromosome segregation (GO:0007059)3.24198895
50mitotic recombination (GO:0006312)3.20501932
51regulation of RNA export from nucleus (GO:0046831)3.17758154
52purine nucleobase biosynthetic process (GO:0009113)3.17665808
53regulation of histone H3-K27 methylation (GO:0061085)3.15932343
54meiosis I (GO:0007127)3.15432319
55ribosomal small subunit assembly (GO:0000028)3.15278377
56DNA topological change (GO:0006265)3.14740081
57negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.12591060
58gene silencing by RNA (GO:0031047)3.10521227
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10296483
60ATP synthesis coupled proton transport (GO:0015986)3.10296483
61meiotic cell cycle (GO:0051321)3.02111333
62chromatin remodeling at centromere (GO:0031055)3.01779037
63meiotic cell cycle process (GO:1903046)3.00714935
64metaphase plate congression (GO:0051310)2.97513862
65ribosomal large subunit biogenesis (GO:0042273)2.97026504
66DNA unwinding involved in DNA replication (GO:0006268)2.95830828
67negative regulation of histone methylation (GO:0031061)2.94190955
68regulation of translational elongation (GO:0006448)2.93660799
69regulation of histone methylation (GO:0031060)2.93153766
70nucleotide-excision repair, DNA gap filling (GO:0006297)2.92237526
71one-carbon compound transport (GO:0019755)2.91079091
72DNA replication-independent nucleosome assembly (GO:0006336)2.90304866
73DNA replication-independent nucleosome organization (GO:0034724)2.90304866
74regulation of histone H3-K9 methylation (GO:0051570)2.89876614
75maturation of 5.8S rRNA (GO:0000460)2.89149448
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87918070
77respiratory electron transport chain (GO:0022904)2.87494629
78regulation of DNA methylation (GO:0044030)2.87412821
79ribosome biogenesis (GO:0042254)2.86946289
80erythrocyte maturation (GO:0043249)2.86188882
81meiotic nuclear division (GO:0007126)2.85272343
82histone exchange (GO:0043486)2.84961974
83folic acid-containing compound biosynthetic process (GO:0009396)2.84712956
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83421766
85centriole replication (GO:0007099)2.82691896
86kinetochore organization (GO:0051383)2.82046654
87homocysteine metabolic process (GO:0050667)2.81670215
88microtubule depolymerization (GO:0007019)2.81593683
89nucleobase biosynthetic process (GO:0046112)2.81399277
90mismatch repair (GO:0006298)2.81386143
91electron transport chain (GO:0022900)2.80695384
92positive regulation of histone H3-K4 methylation (GO:0051571)2.80303959
93proline biosynthetic process (GO:0006561)2.79936206
94translational initiation (GO:0006413)2.79930196
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79816186
96nuclear envelope organization (GO:0006998)2.78061911
97chromosome condensation (GO:0030261)2.77827790
98IMP biosynthetic process (GO:0006188)2.76761274
99telomere maintenance via telomere lengthening (GO:0010833)2.75861507
100regulation of double-strand break repair via homologous recombination (GO:0010569)2.75397758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37223420
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.23182811
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56588660
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.48325386
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.39984943
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.34293872
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.21991454
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17194040
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15784397
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15168231
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13299766
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10219759
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.93628764
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69768627
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63973639
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46787757
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46618798
18DCP1A_22483619_ChIP-Seq_HELA_Human2.36071392
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34984824
20ELK1_19687146_ChIP-ChIP_HELA_Human2.27498880
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18692939
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17866498
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16408366
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.15947985
25VDR_23849224_ChIP-Seq_CD4+_Human2.14366370
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13680639
27FOXP3_21729870_ChIP-Seq_TREG_Human2.13602657
28XRN2_22483619_ChIP-Seq_HELA_Human2.13032799
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06998089
30* NCOR1_26117541_ChIP-Seq_K562_Human2.02384862
31TTF2_22483619_ChIP-Seq_HELA_Human2.00402455
32GABP_19822575_ChIP-Seq_HepG2_Human1.97716542
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96824248
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.95032203
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.94722919
36AR_21909140_ChIP-Seq_LNCAP_Human1.94351408
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94101491
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90586238
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.79088195
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77543941
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76476662
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76292708
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75845390
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.74153480
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73705587
46KDM5A_27292631_Chip-Seq_BREAST_Human1.73262205
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.69261006
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66519679
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63830534
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56064891
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55525803
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48969502
53GATA1_19941826_ChIP-Seq_K562_Human1.42305465
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40665404
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37510989
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35329671
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34761463
58CIITA_25753668_ChIP-Seq_RAJI_Human1.26889244
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25447792
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25259082
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24486261
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23944617
63ZNF263_19887448_ChIP-Seq_K562_Human1.22962315
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21814136
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20783840
66VDR_22108803_ChIP-Seq_LS180_Human1.20284225
67TFEB_21752829_ChIP-Seq_HELA_Human1.18529388
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15192488
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14161635
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12603199
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07161481
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.06080916
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05916980
74* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04322600
75GATA2_19941826_ChIP-Seq_K562_Human1.04117455
76MYC_18940864_ChIP-ChIP_HL60_Human1.02427408
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01504480
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00995507
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95925104
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95684910
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93990550
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93726302
83* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93201297
84TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91303384
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89825077
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88455285
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84518733
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84080366
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83691841
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82116801
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81472253
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80991128
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79058457
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75018189
95RBPJ_21746931_ChIP-Seq_IB4_Human0.73410043
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.73164111
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.72732884
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.72120812
99PHF8_20622853_ChIP-Seq_HELA_Human0.71685831
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.71307513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.35544563
2MP0008995_early_reproductive_senescence4.08664531
3MP0003718_maternal_effect4.01412733
4MP0004957_abnormal_blastocyst_morpholog3.98949782
5MP0008058_abnormal_DNA_repair3.97751060
6MP0010094_abnormal_chromosome_stability3.54404449
7MP0003111_abnormal_nucleus_morphology3.39728070
8MP0003693_abnormal_embryo_hatching3.31850166
9MP0003786_premature_aging3.15953758
10MP0008877_abnormal_DNA_methylation2.76804481
11MP0003077_abnormal_cell_cycle2.67603420
12MP0009697_abnormal_copulation2.60169084
13MP0008932_abnormal_embryonic_tissue2.54129407
14MP0002210_abnormal_sex_determination2.37835485
15MP0000678_abnormal_parathyroid_gland2.34513998
16MP0008057_abnormal_DNA_replication2.33691269
17MP0001929_abnormal_gametogenesis2.31680654
18MP0005451_abnormal_body_composition2.08565626
19MP0005410_abnormal_fertilization2.06325301
20MP0006036_abnormal_mitochondrial_physio2.04187301
21MP0006035_abnormal_mitochondrial_morpho1.94309090
22MP0003186_abnormal_redox_activity1.92950699
23MP0000372_irregular_coat_pigmentation1.91478590
24MP0005083_abnormal_biliary_tract1.87955148
25MP0001661_extended_life_span1.86306464
26MP0008007_abnormal_cellular_replicative1.82439528
27MP0006292_abnormal_olfactory_placode1.78656585
28MP0001145_abnormal_male_reproductive1.72373870
29MP0000653_abnormal_sex_gland1.70914543
30MP0005408_hypopigmentation1.69781510
31MP0003698_abnormal_male_reproductive1.69282160
32MP0002132_abnormal_respiratory_system1.67191834
33MP0003656_abnormal_erythrocyte_physiolo1.64664584
34MP0001730_embryonic_growth_arrest1.64124174
35MP0003806_abnormal_nucleotide_metabolis1.62826893
36MP0010307_abnormal_tumor_latency1.47400874
37MP0000350_abnormal_cell_proliferation1.45910835
38MP0004233_abnormal_muscle_weight1.41732660
39MP0001697_abnormal_embryo_size1.41383574
40MP0001545_abnormal_hematopoietic_system1.41253443
41MP0005397_hematopoietic_system_phenotyp1.41253443
42MP0003646_muscle_fatigue1.36765953
43MP0003699_abnormal_female_reproductive1.35307575
44MP0002161_abnormal_fertility/fecundity1.32623293
45MP0001672_abnormal_embryogenesis/_devel1.31652178
46MP0005380_embryogenesis_phenotype1.31652178
47MP0000358_abnormal_cell_content/1.28542163
48MP0002160_abnormal_reproductive_system1.27068038
49MP0003890_abnormal_embryonic-extraembry1.25837568
50MP0002080_prenatal_lethality1.25672086
51MP0000313_abnormal_cell_death1.25270306
52MP0005171_absent_coat_pigmentation1.23239055
53MP0004145_abnormal_muscle_electrophysio1.19579662
54MP0005395_other_phenotype1.19405086
55MP0001764_abnormal_homeostasis1.17827983
56MP0008775_abnormal_heart_ventricle1.16271868
57MP0003984_embryonic_growth_retardation1.06030693
58MP0002139_abnormal_hepatobiliary_system1.04871597
59MP0002088_abnormal_embryonic_growth/wei1.03109352
60MP0005636_abnormal_mineral_homeostasis1.01570316
61MP0005389_reproductive_system_phenotype1.01448959
62MP0001119_abnormal_female_reproductive1.00684346
63MP0002086_abnormal_extraembryonic_tissu0.97830585
64MP0003959_abnormal_lean_body0.96244334
65MP0002396_abnormal_hematopoietic_system0.90210226
66MP0005332_abnormal_amino_acid0.89754200
67MP0004084_abnormal_cardiac_muscle0.89064087
68MP0003950_abnormal_plasma_membrane0.88670177
69MP0002084_abnormal_developmental_patter0.87642365
70MP0005360_urolithiasis0.85268589
71MP0002085_abnormal_embryonic_tissue0.84989349
72MP0001881_abnormal_mammary_gland0.83482051
73MP0001727_abnormal_embryo_implantation0.82829034
74MP0002269_muscular_atrophy0.80436605
75MP0002019_abnormal_tumor_incidence0.78733526
76MP0005646_abnormal_pituitary_gland0.77629041
77MP0002877_abnormal_melanocyte_morpholog0.75459246
78MP0001529_abnormal_vocalization0.72756879
79MP0001919_abnormal_reproductive_system0.68662866
80MP0000647_abnormal_sebaceous_gland0.65744529
81MP0008789_abnormal_olfactory_epithelium0.65250764
82MP0005647_abnormal_sex_gland0.64507548
83MP0000609_abnormal_liver_physiology0.61425295
84MP0004264_abnormal_extraembryonic_tissu0.61183922
85MP0008770_decreased_survivor_rate0.60826503
86MP0005076_abnormal_cell_differentiation0.60381088
87MP0000631_abnormal_neuroendocrine_gland0.59902463
88MP0009333_abnormal_splenocyte_physiolog0.59244954
89MP0004808_abnormal_hematopoietic_stem0.59191772
90MP0000747_muscle_weakness0.58185017
91MP0003936_abnormal_reproductive_system0.56470630
92MP0005384_cellular_phenotype0.56256104
93MP0004197_abnormal_fetal_growth/weight/0.55071483
94MP0000681_abnormal_thyroid_gland0.54985912
95MP0003123_paternal_imprinting0.54519712
96MP0004019_abnormal_vitamin_homeostasis0.54451295
97MP0009115_abnormal_fat_cell0.54349117
98MP0002095_abnormal_skin_pigmentation0.52536296
99MP0000598_abnormal_liver_morphology0.51662104
100MP0003221_abnormal_cardiomyocyte_apopto0.50470797

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)5.89884055
2Cholecystitis (HP:0001082)5.89884055
3Truncus arteriosus (HP:0001660)4.80437787
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.56650517
5Hyperthyroidism (HP:0000836)4.56513135
6Chromsome breakage (HP:0040012)4.44901407
7Reticulocytosis (HP:0001923)4.20171055
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.88179657
9Abnormality of reticulocytes (HP:0004312)3.76225483
10Abnormal hemoglobin (HP:0011902)3.75440174
11Birth length less than 3rd percentile (HP:0003561)3.55609313
12Abnormality of homocysteine metabolism (HP:0010919)3.40071429
13Homocystinuria (HP:0002156)3.40071429
14Increased hepatocellular lipid droplets (HP:0006565)3.37265517
15Bowel incontinence (HP:0002607)3.26593133
16Polycythemia (HP:0001901)3.20441468
17Seborrheic dermatitis (HP:0001051)3.20227534
18Lipid accumulation in hepatocytes (HP:0006561)3.19647627
19Abnormal large intestine physiology (HP:0012700)3.15871204
20Acute encephalopathy (HP:0006846)3.08720697
21Pallor (HP:0000980)3.00402325
22Renal Fanconi syndrome (HP:0001994)2.98851553
23Abnormality of the preputium (HP:0100587)2.93852234
24Abnormality of glycolysis (HP:0004366)2.92864034
25Acute necrotizing encephalopathy (HP:0006965)2.92586953
26Hypertensive crisis (HP:0100735)2.90997707
27Increased serum pyruvate (HP:0003542)2.90080591
28Poikilocytosis (HP:0004447)2.87479637
29Increased CSF lactate (HP:0002490)2.86809069
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.86423800
31Abnormality of cochlea (HP:0000375)2.86070037
32Abnormal mitochondria in muscle tissue (HP:0008316)2.85132484
33Reticulocytopenia (HP:0001896)2.83451498
34Duodenal stenosis (HP:0100867)2.79814731
35Small intestinal stenosis (HP:0012848)2.79814731
36Male infertility (HP:0003251)2.79748469
37Abnormality of the tricuspid valve (HP:0001702)2.79519130
38Hypoparathyroidism (HP:0000829)2.75295517
39Cholelithiasis (HP:0001081)2.73931711
40Cortical dysplasia (HP:0002539)2.63165303
41Abnormality of chromosome stability (HP:0003220)2.62165023
42Mitochondrial inheritance (HP:0001427)2.61781517
43Upper limb muscle weakness (HP:0003484)2.60755124
44Ileus (HP:0002595)2.60717509
45Ankyloglossia (HP:0010296)2.60225875
46Myelodysplasia (HP:0002863)2.57409045
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.47507491
48Duplicated collecting system (HP:0000081)2.45296087
49Short middle phalanx of the 5th finger (HP:0004220)2.44028506
50Meckel diverticulum (HP:0002245)2.43241783
51Abnormal gallbladder morphology (HP:0012437)2.42920526
52Premature ovarian failure (HP:0008209)2.41867112
53Progressive macrocephaly (HP:0004481)2.41848681
54Abnormality of the renal collecting system (HP:0004742)2.39363940
55Aplasia/Hypoplasia of the earlobes (HP:0009906)2.38984063
56Hepatic necrosis (HP:0002605)2.38644153
57Increased intramyocellular lipid droplets (HP:0012240)2.34147568
58Exertional dyspnea (HP:0002875)2.30353244
59Abnormality of the ileum (HP:0001549)2.29827304
60Respiratory difficulties (HP:0002880)2.28704294
61Abnormality of DNA repair (HP:0003254)2.28301503
62Hepatocellular necrosis (HP:0001404)2.26210349
63Increased serum lactate (HP:0002151)2.26147070
64Morphological abnormality of the inner ear (HP:0011390)2.24454699
65Atelectasis (HP:0100750)2.23244783
66Macrocytic anemia (HP:0001972)2.19035893
67Cerebral edema (HP:0002181)2.13712578
68Ureteral duplication (HP:0000073)2.11480314
69Entropion (HP:0000621)2.08894404
70Septate vagina (HP:0001153)2.08268648
71Acute myeloid leukemia (HP:0004808)2.07007510
72Abnormality of cells of the erythroid lineage (HP:0012130)2.02870338
73Increased muscle lipid content (HP:0009058)2.02779932
74Abnormality of the duodenum (HP:0002246)2.02269693
75Cerebral hypomyelination (HP:0006808)1.98382054
76Acanthocytosis (HP:0001927)1.97747053
77Hypoplasia of the fovea (HP:0007750)1.95643175
78Aplasia/Hypoplasia of the fovea (HP:0008060)1.95643175
79Overlapping toe (HP:0001845)1.95510182
80Abnormality of the gallbladder (HP:0005264)1.93800993
81Lactic acidosis (HP:0003128)1.93407661
82Abnormal number of erythroid precursors (HP:0012131)1.93201190
83CNS hypomyelination (HP:0003429)1.92937407
84Hyperbilirubinemia (HP:0002904)1.91201539
85Abnormality of methionine metabolism (HP:0010901)1.85814229
86Abnormal lung lobation (HP:0002101)1.85600799
87Secondary amenorrhea (HP:0000869)1.83927078
88Abnormality of the carotid arteries (HP:0005344)1.83609104
89Tinnitus (HP:0000360)1.78289633
90Absent thumb (HP:0009777)1.77713007
91Horseshoe kidney (HP:0000085)1.73723771
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73110453
93Cafe-au-lait spot (HP:0000957)1.71977870
94Increased nuchal translucency (HP:0010880)1.71171561
95Abnormality of the fovea (HP:0000493)1.70843824
96Redundant skin (HP:0001582)1.69624684
97Abnormality of renal resorption (HP:0011038)1.69210487
98Respiratory failure (HP:0002878)1.68821642
99Hyperphosphaturia (HP:0003109)1.68705357
100Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67240698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.88971658
2TTK3.66422819
3KSR23.29659415
4PBK3.12040606
5EIF2AK33.11371905
6RIPK42.90729256
7RAF12.66048471
8CLK12.60630498
9BUB12.56080134
10PLK42.45314067
11BMPR22.43311528
12CDC72.36172494
13KSR12.30209716
14CCNB12.27374404
15NEK12.25884807
16NTRK32.11699788
17WEE12.10449780
18BRSK22.04842748
19NME12.04597073
20MAP3K22.01518412
21TRIM281.92697876
22MST41.83309330
23SRPK11.71812244
24ZAK1.63876388
25EEF2K1.60307958
26NME21.50089980
27SCYL21.49050533
28BRSK11.48495129
29NEK21.38077784
30MAP3K81.34980730
31RPS6KB21.29575494
32BRAF1.25873903
33MAP3K41.24038202
34CHEK21.23346247
35STK161.23282273
36ACVR1B1.21324758
37PDK21.20125554
38STK31.12794066
39PLK11.12469935
40PLK31.10913306
41STK41.03373717
42SIK31.01941302
43ATR0.96188765
44CHEK10.95382489
45BMX0.91481250
46TSSK60.89444369
47ILK0.85755327
48NUAK10.81902797
49AURKA0.80682257
50IRAK30.80409813
51ARAF0.79298328
52PIK3CG0.79203856
53AURKB0.76320124
54CDK10.73680452
55MAP2K10.73106175
56TRPM70.72148244
57NEK60.71977358
58ATM0.69465194
59CDK20.68772716
60MARK30.67584790
61PIM10.65317615
62PAK10.64971282
63WNK40.63584162
64CDK70.63112451
65EIF2AK20.59663017
66CSNK2A20.56837299
67PLK20.56412799
68MKNK10.52411966
69CSNK2A10.49092985
70BCR0.47842176
71MAPKAPK50.47738007
72LRRK20.46653874
73ICK0.46607245
74PRKCI0.44945840
75RET0.43778050
76CSNK1E0.42734893
77RPS6KA50.42400579
78MAP3K60.40197149
79DMPK0.39856383
80CDK120.38948644
81TESK20.38863613
82MAP3K90.38841138
83MUSK0.37520793
84TAOK30.37491604
85VRK10.37061963
86JAK20.36164307
87ALK0.34533935
88MAPKAPK30.34414175
89PNCK0.31977276
90WNK10.31534706
91MAP3K10.31146624
92PASK0.27616060
93YES10.26265276
94GSK3B0.25566227
95CDK80.25334378
96MAP2K70.24043186
97MAPK140.23996687
98MAP4K20.22347073
99MTOR0.20875085
100RPS6KA40.20364256

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.85740271
2DNA replication_Homo sapiens_hsa030303.70061897
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.64790571
4Homologous recombination_Homo sapiens_hsa034403.09852551
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88420565
6Ribosome_Homo sapiens_hsa030102.83919673
7One carbon pool by folate_Homo sapiens_hsa006702.63188445
8Oxidative phosphorylation_Homo sapiens_hsa001902.56518651
9Proteasome_Homo sapiens_hsa030502.56478288
10RNA transport_Homo sapiens_hsa030132.54729595
11Basal transcription factors_Homo sapiens_hsa030222.52521797
12Nucleotide excision repair_Homo sapiens_hsa034202.43418594
13Fanconi anemia pathway_Homo sapiens_hsa034602.40834469
14Parkinsons disease_Homo sapiens_hsa050122.36444797
15Cell cycle_Homo sapiens_hsa041102.29455094
16Spliceosome_Homo sapiens_hsa030402.19875284
17RNA polymerase_Homo sapiens_hsa030202.12593025
18Huntingtons disease_Homo sapiens_hsa050161.85865026
19Base excision repair_Homo sapiens_hsa034101.85760817
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.84056651
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80740947
22Steroid biosynthesis_Homo sapiens_hsa001001.78142314
23RNA degradation_Homo sapiens_hsa030181.75322340
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69023307
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68906656
26Protein export_Homo sapiens_hsa030601.65708324
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59770354
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51618248
29Alzheimers disease_Homo sapiens_hsa050101.41993631
30Oocyte meiosis_Homo sapiens_hsa041141.41769362
31mRNA surveillance pathway_Homo sapiens_hsa030151.35355079
32Pyruvate metabolism_Homo sapiens_hsa006201.35290428
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30144057
34Pyrimidine metabolism_Homo sapiens_hsa002401.27925250
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.27764538
36Carbon metabolism_Homo sapiens_hsa012001.24855283
37Biosynthesis of amino acids_Homo sapiens_hsa012301.16174432
38Propanoate metabolism_Homo sapiens_hsa006401.15555618
39Selenocompound metabolism_Homo sapiens_hsa004501.09551272
40Olfactory transduction_Homo sapiens_hsa047401.05276789
41Folate biosynthesis_Homo sapiens_hsa007901.04914135
42Non-homologous end-joining_Homo sapiens_hsa034501.03546730
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01042447
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98231993
45Fatty acid elongation_Homo sapiens_hsa000620.98095168
46Purine metabolism_Homo sapiens_hsa002300.94339638
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91260432
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87405600
49Butanoate metabolism_Homo sapiens_hsa006500.87160119
50Cardiac muscle contraction_Homo sapiens_hsa042600.81847603
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81249334
52Fructose and mannose metabolism_Homo sapiens_hsa000510.79903868
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77406763
54Pentose phosphate pathway_Homo sapiens_hsa000300.73521567
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72551397
56Fatty acid metabolism_Homo sapiens_hsa012120.72035280
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71716039
58Glutathione metabolism_Homo sapiens_hsa004800.70717797
59Arginine biosynthesis_Homo sapiens_hsa002200.69944666
60N-Glycan biosynthesis_Homo sapiens_hsa005100.68931070
61Metabolic pathways_Homo sapiens_hsa011000.65406861
62Vitamin B6 metabolism_Homo sapiens_hsa007500.60548193
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.57973057
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56468519
65Acute myeloid leukemia_Homo sapiens_hsa052210.56308865
66mTOR signaling pathway_Homo sapiens_hsa041500.48206039
67Thyroid cancer_Homo sapiens_hsa052160.47559742
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46592035
69Sulfur relay system_Homo sapiens_hsa041220.45302127
70p53 signaling pathway_Homo sapiens_hsa041150.43707056
71Viral carcinogenesis_Homo sapiens_hsa052030.42030793
72Epstein-Barr virus infection_Homo sapiens_hsa051690.38769145
73HIF-1 signaling pathway_Homo sapiens_hsa040660.37940332
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35233710
75Arginine and proline metabolism_Homo sapiens_hsa003300.33081354
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30759788
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.29159801
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28269018
79Fatty acid biosynthesis_Homo sapiens_hsa000610.27756414
80Type II diabetes mellitus_Homo sapiens_hsa049300.25937698
81Sulfur metabolism_Homo sapiens_hsa009200.25797524
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23885195
83ErbB signaling pathway_Homo sapiens_hsa040120.20867797
84Insulin signaling pathway_Homo sapiens_hsa049100.18869258
85Chronic myeloid leukemia_Homo sapiens_hsa052200.18791039
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16515364
87Tyrosine metabolism_Homo sapiens_hsa003500.15965508
88Renal cell carcinoma_Homo sapiens_hsa052110.14786391
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.13303729
90VEGF signaling pathway_Homo sapiens_hsa043700.12931338
91Non-small cell lung cancer_Homo sapiens_hsa052230.12521896
92Caffeine metabolism_Homo sapiens_hsa002320.11311688
93Dorso-ventral axis formation_Homo sapiens_hsa043200.10429705
94Vibrio cholerae infection_Homo sapiens_hsa051100.10111752
95Collecting duct acid secretion_Homo sapiens_hsa049660.09386806
96Inositol phosphate metabolism_Homo sapiens_hsa005620.09168746
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.08313526
98Regulation of autophagy_Homo sapiens_hsa041400.07884469
99Pancreatic cancer_Homo sapiens_hsa052120.07321325
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.04226038

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