DSE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.07444411
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.07444411
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.07444411
4modulation by symbiont of host immune response (GO:0052553)5.07444411
5positive regulation by symbiont of host defense response (GO:0052509)5.07444411
6modulation by symbiont of host defense response (GO:0052031)5.07444411
7regulation of vitamin D biosynthetic process (GO:0060556)4.67935040
8positive regulation of interferon-alpha production (GO:0032727)4.57153846
9negative regulation of interleukin-12 production (GO:0032695)4.51948429
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36519430
11regulation of interferon-beta biosynthetic process (GO:0045357)4.29994938
12regulation of interferon-alpha production (GO:0032647)4.28206589
13cellular response to interferon-alpha (GO:0035457)4.04814256
14cell adhesion mediated by integrin (GO:0033627)3.98289300
15wound healing, spreading of epidermal cells (GO:0035313)3.95521533
16neutrophil activation involved in immune response (GO:0002283)3.81093282
17apoptotic cell clearance (GO:0043277)3.76464488
18regulation of vitamin metabolic process (GO:0030656)3.59158759
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.53748838
20hemidesmosome assembly (GO:0031581)3.52749072
21macrophage activation involved in immune response (GO:0002281)3.52651475
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.49315002
23regulation of T-helper 1 cell differentiation (GO:0045625)3.49249914
24collagen fibril organization (GO:0030199)3.46718753
25regulation of mononuclear cell migration (GO:0071675)3.43903850
26immunoglobulin mediated immune response (GO:0016064)3.42096839
27protein heterotrimerization (GO:0070208)3.39696526
28positive regulation of interferon-beta production (GO:0032728)3.33362336
29protein localization to endosome (GO:0036010)3.31112136
30T-helper 1 type immune response (GO:0042088)3.29591819
31endodermal cell differentiation (GO:0035987)3.25585133
32positive regulation of SMAD protein import into nucleus (GO:0060391)3.24613742
33positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.24305134
34positive regulation of chemokine biosynthetic process (GO:0045080)3.24050020
35response to peptidoglycan (GO:0032494)3.18950056
36response to host immune response (GO:0052572)3.18039577
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18039577
38positive regulation of type 2 immune response (GO:0002830)3.16221651
39pinocytosis (GO:0006907)3.15028919
40response to interferon-alpha (GO:0035455)3.13857093
41regulation of SMAD protein import into nucleus (GO:0060390)3.13560601
42wound healing, spreading of cells (GO:0044319)3.00656397
43regulation of podosome assembly (GO:0071801)3.00431635
44positive regulation of heat generation (GO:0031652)2.99225831
45regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97802256
46regulation of T-helper 2 cell differentiation (GO:0045628)2.96796363
47microglial cell activation (GO:0001774)2.94324511
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93565507
49response to host (GO:0075136)2.93565507
50response to host defenses (GO:0052200)2.93565507
51regulation of integrin activation (GO:0033623)2.93282749
52B cell mediated immunity (GO:0019724)2.92459256
53regulation of fever generation (GO:0031620)2.92037488
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91744800
55regulation of cholesterol storage (GO:0010885)2.91449150
56detection of molecule of bacterial origin (GO:0032490)2.88844793
57virion attachment to host cell (GO:0019062)2.86095273
58adhesion of symbiont to host cell (GO:0044650)2.86095273
59low-density lipoprotein particle clearance (GO:0034383)2.85989040
60basement membrane organization (GO:0071711)2.84640087
61positive regulation of cellular amide metabolic process (GO:0034250)2.83981673
62cellular extravasation (GO:0045123)2.83745105
63production of molecular mediator involved in inflammatory response (GO:0002532)2.82047217
64axon extension involved in axon guidance (GO:0048846)2.81566660
65neuron projection extension involved in neuron projection guidance (GO:1902284)2.81566660
66positive regulation of endothelial cell apoptotic process (GO:2000353)2.81436034
67detection of external biotic stimulus (GO:0098581)2.77657516
68collagen metabolic process (GO:0032963)2.76599521
69positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.76235446
70positive regulation of interleukin-6 production (GO:0032755)2.76018527
71regulation of cytokine secretion involved in immune response (GO:0002739)2.75746423
72I-kappaB phosphorylation (GO:0007252)2.74587778
73regulation of chemokine biosynthetic process (GO:0045073)2.72909470
74nuclear pore complex assembly (GO:0051292)2.72530203
75positive regulation of NF-kappaB import into nucleus (GO:0042346)2.72155312
76chondrocyte proliferation (GO:0035988)2.72068492
77natural killer cell mediated cytotoxicity (GO:0042267)2.70173287
78natural killer cell mediated immunity (GO:0002228)2.70173287
79collagen catabolic process (GO:0030574)2.69763447
80regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.69564030
81negative regulation of lipid storage (GO:0010888)2.69433029
82negative regulation of nitric oxide biosynthetic process (GO:0045019)2.69236823
83positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.69146207
84keratan sulfate catabolic process (GO:0042340)2.68406975
85positive regulation of macrophage cytokine production (GO:0060907)2.68215493
86positive regulation of natural killer cell differentiation (GO:0032825)2.67504195
87substrate-dependent cell migration (GO:0006929)2.66626142
88positive regulation of p38MAPK cascade (GO:1900745)2.66186084
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.65640120
90negative regulation of interleukin-17 production (GO:0032700)2.63226876
91macrophage activation (GO:0042116)2.62408447
92cellular response to thyroid hormone stimulus (GO:0097067)2.62086070
93response to muramyl dipeptide (GO:0032495)2.61963447
94regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60800360
95detection of other organism (GO:0098543)2.60343887
96nuclear pore organization (GO:0006999)2.59230138
97regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.58508972
98positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57589339
99stress fiber assembly (GO:0043149)2.56080885
100detection of biotic stimulus (GO:0009595)2.56023537
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56008190
102positive regulation vascular endothelial growth factor production (GO:0010575)2.55635762
103positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.54816451
104regulation of macrophage cytokine production (GO:0010935)2.54797102
105negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.54477609
106cellular response to lipopolysaccharide (GO:0071222)2.54449409
107interferon-gamma-mediated signaling pathway (GO:0060333)2.53490760
108multicellular organismal macromolecule metabolic process (GO:0044259)2.52965713
109response to laminar fluid shear stress (GO:0034616)2.51676608
110regulation of type 2 immune response (GO:0002828)2.51057014
111regulation of macrophage chemotaxis (GO:0010758)2.50980632
112cellular response to molecule of bacterial origin (GO:0071219)2.50930095
113cell-substrate junction assembly (GO:0007044)2.50528291
114phagocytosis, engulfment (GO:0006911)2.50258237
115positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.49222411
116cellular response to vitamin D (GO:0071305)2.48117536
117regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47568889
118regulation of nitric oxide biosynthetic process (GO:0045428)2.45743837
119type I interferon signaling pathway (GO:0060337)2.44893043
120cellular response to type I interferon (GO:0071357)2.44893043
121adhesion of symbiont to host (GO:0044406)2.44455315
122phagocytosis, recognition (GO:0006910)2.43165189
123positive regulation of gamma-delta T cell activation (GO:0046645)2.43012543
124regulation of antigen processing and presentation (GO:0002577)2.41717514
125response to type I interferon (GO:0034340)2.41177366
126positive regulation of nitric oxide biosynthetic process (GO:0045429)2.41009235
127fibril organization (GO:0097435)2.40999574
128positive regulation of acute inflammatory response (GO:0002675)2.40924271
129positive regulation of chemokine production (GO:0032722)2.40580130
130multicellular organismal catabolic process (GO:0044243)2.40296661
131positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40060507
132regulation of interleukin-12 production (GO:0032655)2.39734257
133pore complex assembly (GO:0046931)2.39689723
134monocyte chemotaxis (GO:0002548)2.39527737
135multicellular organismal metabolic process (GO:0044236)2.39248775
136regulation of monocyte chemotaxis (GO:0090025)2.38927092
137granulocyte activation (GO:0036230)2.38720171
138hyaluronan catabolic process (GO:0030214)2.38640939
139germinal center formation (GO:0002467)2.38449947
140NIK/NF-kappaB signaling (GO:0038061)2.38216949
141negative regulation of granulocyte differentiation (GO:0030853)2.37633405
142regulation of interferon-beta production (GO:0032648)2.37497116
143positive regulation of monocyte chemotaxis (GO:0090026)2.36585364
144neutrophil activation (GO:0042119)2.36458356
145regulation of gene silencing by RNA (GO:0060966)2.35150978
146regulation of posttranscriptional gene silencing (GO:0060147)2.35150978
147regulation of gene silencing by miRNA (GO:0060964)2.35150978
148skin morphogenesis (GO:0043589)2.34897095
149regulation of interleukin-8 biosynthetic process (GO:0045414)2.33870309
150cellular response to virus (GO:0098586)2.33707426
151regulation of vascular endothelial growth factor production (GO:0010574)2.32378900
152positive regulation of protein import into nucleus, translocation (GO:0033160)2.32167627
153retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31715841
154positive regulation of antigen processing and presentation (GO:0002579)2.30987860
155regulation of membrane protein ectodomain proteolysis (GO:0051043)2.28542492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.89811148
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.34929655
3E2F7_22180533_ChIP-Seq_HELA_Human4.21144973
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.99892099
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.66583327
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35069348
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.16963424
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.15922591
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.09014583
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.97395056
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85609440
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.82513146
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70936412
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58995851
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.44082149
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43327504
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40855236
18CLOCK_20551151_ChIP-Seq_293T_Human2.17392255
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16874065
20* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.11627595
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08381389
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07106850
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07106850
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07106850
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05342134
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97280840
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.94216155
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93038572
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90965743
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87161112
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.83389915
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83014642
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79730624
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76012931
35NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.69941463
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67438338
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65458850
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.64725368
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.64344563
40CJUN_26792858_Chip-Seq_BT549_Human1.64209152
41* BRD4_25478319_ChIP-Seq_HGPS_Human1.63679691
42* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57655215
43* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57655215
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55385366
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54264403
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54134186
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53490980
48TFEB_21752829_ChIP-Seq_HELA_Human1.51931182
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51412373
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49590724
51GATA1_22025678_ChIP-Seq_K562_Human1.48480068
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44995183
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44385271
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.38036509
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37906571
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37696473
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36702738
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35969393
59SPI1_23127762_ChIP-Seq_K562_Human1.35443121
60* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33149801
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.32754997
62* PU_27001747_Chip-Seq_BMDM_Mouse1.32391299
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29389556
64SPI1_23547873_ChIP-Seq_NB4_Human1.28614497
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28207518
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27980098
67TP53_16413492_ChIP-PET_HCT116_Human1.27975326
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.27215988
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25401385
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25401385
71ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22391491
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22181033
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19565585
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14962440
75* TP63_23658742_ChIP-Seq_EP156T_Human1.14065675
76* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13727883
77VDR_24787735_ChIP-Seq_THP-1_Human1.13676444
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12949894
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12700514
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.12420910
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11823468
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11744365
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.10358354
84RUNX_20019798_ChIP-Seq_JUKART_Human1.06444550
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06023985
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05758859
87AR_21909140_ChIP-Seq_LNCAP_Human1.05625761
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05364452
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03036859
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01396284
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.01013274
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00764493
93* TP53_18474530_ChIP-ChIP_U2OS_Human1.00238190
94SOX2_20726797_ChIP-Seq_SW620_Human0.99831416
95* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99798110
96E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99038668
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98931210
98ELK1_19687146_ChIP-ChIP_HELA_Human0.98523850
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98376602
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.98217920
101MYB_26560356_Chip-Seq_TH2_Human0.98073018
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97923978
103* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97831811
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97702047
105SCL_19346495_ChIP-Seq_HPC-7_Human0.96796264
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95427234
107* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95112820
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94397711
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94159696
110RUNX1_22412390_ChIP-Seq_EML_Mouse0.94061306
111P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92578549
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92237020
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92066626
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91778430
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91420563
116* GATA2_21666600_ChIP-Seq_HMVEC_Human0.90659833
117VDR_24763502_ChIP-Seq_THP-1_Human0.90588670
118NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90466114
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90389926
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90077727
121* ATF3_27146783_Chip-Seq_COLON_Human0.89773046
122MYB_26560356_Chip-Seq_TH1_Human0.89592794
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88138400
124MAF_26560356_Chip-Seq_TH1_Human0.87823333
125* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86761841
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86630483
127E2F1_21310950_ChIP-Seq_MCF-7_Human0.85226922
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83974304
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79316116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008438_abnormal_cutaneous_collagen5.58533114
2* MP0005275_abnormal_skin_tensile2.97074287
3* MP0003705_abnormal_hypodermis_morpholog2.80488257
4MP0005503_abnormal_tendon_morphology2.73098159
5MP0003279_aneurysm2.72468522
6MP0001958_emphysema2.36542965
7MP0003566_abnormal_cell_adhesion2.34188329
8MP0005058_abnormal_lysosome_morphology2.19380657
9MP0001835_abnormal_antigen_presentation2.19277632
10MP0003436_decreased_susceptibility_to2.17612285
11MP0010352_gastrointestinal_tract_polyps2.17423194
12MP0008004_abnormal_stomach_pH2.11757906
13MP0005257_abnormal_intraocular_pressure2.08941168
14MP0000569_abnormal_digit_pigmentation1.97209436
15MP0005076_abnormal_cell_differentiation1.94517156
16MP0010307_abnormal_tumor_latency1.91138897
17MP0005023_abnormal_wound_healing1.90959323
18MP0003303_peritoneal_inflammation1.85837293
19MP0004272_abnormal_basement_membrane1.84987784
20MP0003448_altered_tumor_morphology1.81579697
21MP0006082_CNS_inflammation1.81480845
22MP0001533_abnormal_skeleton_physiology1.74934563
23MP0003091_abnormal_cell_migration1.73939452
24MP0002419_abnormal_innate_immunity1.66041389
25MP0009764_decreased_sensitivity_to1.64332119
26MP0002148_abnormal_hypersensitivity_rea1.63751504
27MP0005623_abnormal_meninges_morphology1.58849596
28MP0003950_abnormal_plasma_membrane1.52941668
29MP0003724_increased_susceptibility_to1.52742195
30MP0000767_abnormal_smooth_muscle1.48276273
31MP0005390_skeleton_phenotype1.47901238
32MP0001849_ear_inflammation1.45515891
33MP0005000_abnormal_immune_tolerance1.44053148
34MP0009840_abnormal_foam_cell1.40750304
35MP0002998_abnormal_bone_remodeling1.39790523
36MP0000858_altered_metastatic_potential1.38763121
37MP0005508_abnormal_skeleton_morphology1.38071436
38MP0009785_altered_susceptibility_to1.37079219
39MP0006054_spinal_hemorrhage1.35776763
40MP0002295_abnormal_pulmonary_circulatio1.33977577
41MP0002452_abnormal_antigen_presenting1.28235323
42MP0005671_abnormal_response_to1.27440044
43MP0001790_abnormal_immune_system1.27315137
44MP0005387_immune_system_phenotype1.27315137
45MP0001243_abnormal_dermal_layer1.27267120
46MP0002332_abnormal_exercise_endurance1.26321940
47MP0000733_abnormal_muscle_development1.26196215
48MP0000685_abnormal_immune_system1.25402123
49MP0001915_intracranial_hemorrhage1.25326191
50MP0008260_abnormal_autophagy1.25054024
51* MP0002060_abnormal_skin_morphology1.22731551
52MP0000343_altered_response_to1.21236542
53MP0002933_joint_inflammation1.20020667
54MP0005025_abnormal_response_to1.19421793
55MP0003172_abnormal_lysosome_physiology1.18771982
56MP0009384_cardiac_valve_regurgitation1.18739186
57MP0009278_abnormal_bone_marrow1.18533780
58MP0010155_abnormal_intestine_physiology1.18502540
59MP0010030_abnormal_orbit_morphology1.17289851
60MP0001545_abnormal_hematopoietic_system1.13480835
61MP0005397_hematopoietic_system_phenotyp1.13480835
62MP0005451_abnormal_body_composition1.12993906
63MP0005166_decreased_susceptibility_to1.11747991
64MP0002877_abnormal_melanocyte_morpholog1.11162967
65MP0004947_skin_inflammation1.11019971
66MP0009053_abnormal_anal_canal1.10568676
67MP0001542_abnormal_bone_strength1.09759659
68MP0003828_pulmonary_edema1.05973708
69MP0003191_abnormal_cellular_cholesterol1.05603517
70MP0004510_myositis1.04660011
71MP0003941_abnormal_skin_development1.03728370
72MP0002405_respiratory_system_inflammati1.03072020
73MP0005164_abnormal_response_to1.02900293
74MP0000604_amyloidosis1.02094309
75MP0005165_increased_susceptibility_to1.00907889
76MP0003300_gastrointestinal_ulcer1.00401491
77MP0002006_tumorigenesis0.98306675
78MP0005595_abnormal_vascular_smooth0.98149327
79MP0002282_abnormal_trachea_morphology0.97524113
80MP0000516_abnormal_urinary_system0.97477793
81MP0005367_renal/urinary_system_phenotyp0.97477793
82MP0001800_abnormal_humoral_immune0.96337304
83MP0002723_abnormal_immune_serum0.95381405
84MP0008469_abnormal_protein_level0.94233356
85MP0001851_eye_inflammation0.93329285
86MP0002254_reproductive_system_inflammat0.92414954
87MP0003795_abnormal_bone_structure0.92194910
88MP0005197_abnormal_uvea_morphology0.89811621
89MP0002115_abnormal_skeleton_extremities0.88265088
90MP0008007_abnormal_cellular_replicative0.87338897
91MP0001175_abnormal_lung_morphology0.86708781
92MP0001819_abnormal_immune_cell0.86697120
93MP0001216_abnormal_epidermal_layer0.85753900
94MP0002166_altered_tumor_susceptibility0.85719999
95MP0009763_increased_sensitivity_to0.84608396
96MP0002420_abnormal_adaptive_immunity0.84098601
97MP0010368_abnormal_lymphatic_system0.83508299
98MP0002113_abnormal_skeleton_development0.83279861
99MP0002896_abnormal_bone_mineralization0.80508041
100MP0002168_other_aberrant_phenotype0.80337969
101MP0001845_abnormal_inflammatory_respons0.80120189
102MP0005167_abnormal_blood-brain_barrier0.79616381
103MP0004883_abnormal_blood_vessel0.79017051
104MP0003385_abnormal_body_wall0.78473482
105MP0000428_abnormal_craniofacial_morphol0.77617179
106MP0001614_abnormal_blood_vessel0.77115644
107MP0000371_diluted_coat_color0.76814108
108MP0005464_abnormal_platelet_physiology0.76803228
109MP0003453_abnormal_keratinocyte_physiol0.76422978
110MP0003045_fibrosis0.74237232
111MP0004808_abnormal_hematopoietic_stem0.72807550
112MP0001853_heart_inflammation0.72265322
113MP0000465_gastrointestinal_hemorrhage0.71928284
114MP0002133_abnormal_respiratory_system0.71555198
115MP0005388_respiratory_system_phenotype0.71555198
116MP0000627_abnormal_mammary_gland0.71446464
117MP0010234_abnormal_vibrissa_follicle0.70838880
118MP0001879_abnormal_lymphatic_vessel0.70731888
119MP0005310_abnormal_salivary_gland0.70006445
120MP0000579_abnormal_nail_morphology0.69774388
121MP0004185_abnormal_adipocyte_glucose0.69596943
122MP0000249_abnormal_blood_vessel0.69572887
123MP0002128_abnormal_blood_circulation0.69081392
124MP0003075_altered_response_to0.68772383
125MP0004197_abnormal_fetal_growth/weight/0.68743549
126MP0009333_abnormal_splenocyte_physiolog0.68687048
127MP0000163_abnormal_cartilage_morphology0.67712409

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.47997057
2Protrusio acetabuli (HP:0003179)5.23833245
3Peritonitis (HP:0002586)3.74308733
4Systemic lupus erythematosus (HP:0002725)3.69686185
5Cervical subluxation (HP:0003308)3.62429656
6Aortic dissection (HP:0002647)3.49472235
7Cerebral aneurysm (HP:0004944)3.46737175
8Ankle contracture (HP:0006466)3.44506396
9Shallow orbits (HP:0000586)3.43066564
10Vertebral compression fractures (HP:0002953)3.40100467
11Recurrent abscess formation (HP:0002722)3.40086878
12Osteolytic defects of the hand bones (HP:0009699)3.30945783
13Osteolytic defects of the phalanges of the hand (HP:0009771)3.30945783
14Eczematoid dermatitis (HP:0000976)3.15920912
15Soft skin (HP:0000977)3.15022775
16Aortic aneurysm (HP:0004942)3.05276598
17Myocardial infarction (HP:0001658)2.98124179
18Dilatation of the ascending aorta (HP:0005111)2.97552382
19Recurrent bacterial skin infections (HP:0005406)2.87027758
20Syringomyelia (HP:0003396)2.71951106
21Spinal cord lesions (HP:0100561)2.71951106
22Glomerulonephritis (HP:0000099)2.69540666
23Atrophic scars (HP:0001075)2.69181020
24Increased cerebral lipofuscin (HP:0011813)2.68930333
25Wormian bones (HP:0002645)2.63959747
26Hematochezia (HP:0002573)2.61410175
27Mitral valve prolapse (HP:0001634)2.57732053
28Wrist flexion contracture (HP:0001239)2.57414520
29Recurrent gram-negative bacterial infections (HP:0005420)2.56626100
30Optic neuritis (HP:0100653)2.55888359
31Retrobulbar optic neuritis (HP:0100654)2.55888359
32Genu recurvatum (HP:0002816)2.51778515
33Bladder diverticulum (HP:0000015)2.41292451
34Absent frontal sinuses (HP:0002688)2.40707164
35Vascular tortuosity (HP:0004948)2.39890679
36Biconcave vertebral bodies (HP:0004586)2.38222219
37Vacuolated lymphocytes (HP:0001922)2.37167999
38* Blue sclerae (HP:0000592)2.37096525
39Agnosia (HP:0010524)2.35158324
40Loss of speech (HP:0002371)2.31155838
41Ulnar bowing (HP:0003031)2.29805267
42Abnormality of macrophages (HP:0004311)2.28723865
43Increased mean platelet volume (HP:0011877)2.28018138
44Disinhibition (HP:0000734)2.27481949
45Increased connective tissue (HP:0009025)2.27402851
46Thick nail (HP:0001805)2.26627201
47Follicular hyperkeratosis (HP:0007502)2.22807971
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.22384377
49Neonatal short-limb short stature (HP:0008921)2.20491063
50Nephritis (HP:0000123)2.20008632
51Abnormality of complement system (HP:0005339)2.19431100
52Abnormal platelet volume (HP:0011876)2.19128738
53Spondylolisthesis (HP:0003302)2.18802007
54Milia (HP:0001056)2.18427149
55Autoimmune thrombocytopenia (HP:0001973)2.14208723
56Keratoconjunctivitis sicca (HP:0001097)2.13134081
57Abnormality of dentin (HP:0010299)2.13071571
58Spontaneous hematomas (HP:0007420)2.10666946
59Abnormality of the peritoneum (HP:0002585)2.10183644
60Broad metatarsal (HP:0001783)2.08536727
61Fragile skin (HP:0001030)2.07753279
62Premature loss of primary teeth (HP:0006323)2.05799860
63Prostate neoplasm (HP:0100787)2.03590129
64Tetraparesis (HP:0002273)2.02908101
65Radial bowing (HP:0002986)2.02810136
66Camptodactyly of toe (HP:0001836)1.99563642
67Short nail (HP:0001799)1.99312144
68Arterial tortuosity (HP:0005116)1.99260090
69Orchitis (HP:0100796)1.99218993
70Amyloidosis (HP:0011034)1.98266578
71Thoracolumbar scoliosis (HP:0002944)1.98266007
72Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.97786079
73Spinal rigidity (HP:0003306)1.97682900
74Alopecia of scalp (HP:0002293)1.96991988
75Natal tooth (HP:0000695)1.96376479
76Gingivitis (HP:0000230)1.95983405
77Axonal loss (HP:0003447)1.95434456
78Myositis (HP:0100614)1.95307780
79Neurofibrillary tangles (HP:0002185)1.95088127
80Cupped ribs (HP:0000887)1.94564897
81Tibial bowing (HP:0002982)1.93505194
82Mediastinal lymphadenopathy (HP:0100721)1.92433259
83Abnormality of the acetabulum (HP:0003170)1.91147548
84Ovoid vertebral bodies (HP:0003300)1.90055419
85Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89041492
86Mesomelia (HP:0003027)1.87309426
87Urinary glycosaminoglycan excretion (HP:0003541)1.86665633
88Mucopolysacchariduria (HP:0008155)1.86665633
89Mitral stenosis (HP:0001718)1.85980207
90Abnormality of the distal phalanges of the toes (HP:0010182)1.85516163
91Pathologic fracture (HP:0002756)1.85417821
92Emphysema (HP:0002097)1.85382182
93Keratoconjunctivitis (HP:0001096)1.85306724
94Elbow flexion contracture (HP:0002987)1.84654564
95Coxa vara (HP:0002812)1.84584764
96Subacute progressive viral hepatitis (HP:0006572)1.84166955
97Slender build (HP:0001533)1.83758832
98Increased density of long bones (HP:0006392)1.83737811
99Onycholysis (HP:0001806)1.83690071
100Metaphyseal cupping (HP:0003021)1.83174198
101Abnormality of polysaccharide metabolism (HP:0011012)1.82734114
102Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82734114
103Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82734114
104Abnormal delivery (HP:0001787)1.82693562
105Periodontitis (HP:0000704)1.82189298
106Overgrowth (HP:0001548)1.81452790
107Recurrent skin infections (HP:0001581)1.81349106
108Aneurysm (HP:0002617)1.81132398
109Complement deficiency (HP:0004431)1.78274984
110Interstitial pulmonary disease (HP:0006530)1.76909223
111Pulmonary infiltrates (HP:0002113)1.76867183
112Joint laxity (HP:0001388)1.76818949
113Pulmonary artery stenosis (HP:0004415)1.76779860
114Abnormality of glycosphingolipid metabolism (HP:0004343)1.76187277
115Abnormality of glycolipid metabolism (HP:0010969)1.76187277
116Abnormality of liposaccharide metabolism (HP:0010968)1.76187277
117Hemoptysis (HP:0002105)1.76140691
118Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75583934
119Fused cervical vertebrae (HP:0002949)1.75435642
120Hyperextensible skin (HP:0000974)1.75124185
121Plantar hyperkeratosis (HP:0007556)1.75112059
122Dysostosis multiplex (HP:0000943)1.71812665
123Elevated erythrocyte sedimentation rate (HP:0003565)1.70997420
124Femoral bowing (HP:0002980)1.69995751
125Gingival bleeding (HP:0000225)1.69818048
126Asymmetric septal hypertrophy (HP:0001670)1.69297188
127Basal ganglia calcification (HP:0002135)1.68525155
128Persistence of primary teeth (HP:0006335)1.68491286
129Flared iliac wings (HP:0002869)1.67436108
130Platyspondyly (HP:0000926)1.67356602
131Purpura (HP:0000979)1.67137795
132Type 1 muscle fiber predominance (HP:0003803)1.65626981
133Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.65419335
134Hypoplastic ischia (HP:0003175)1.65261477
135Joint contractures involving the joints of the feet (HP:0100492)1.64171249
136Flexion contracture of toe (HP:0005830)1.64171249
137Osteoarthritis (HP:0002758)1.64169715
138Thin bony cortex (HP:0002753)1.63381727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR23.10095957
2TTN2.98504592
3MAP3K142.98205110
4STK242.69326117
5GRK72.67820697
6BLK2.41673737
7TYK22.29246182
8PBK2.13860963
9TBK12.10531390
10NEK92.09046233
11PKN22.06361900
12PDGFRA2.06020391
13LATS11.95174332
14SCYL21.93896944
15PRPF4B1.92079734
16JAK11.85861065
17MYLK1.85040284
18RPS6KA41.84968721
19ERN11.82995620
20TGFBR21.78424579
21CDK121.77958077
22STK31.75436858
23TRIB31.71859998
24TRPM71.71107933
25RIPK11.70265588
26CDC42BPA1.64373862
27BMX1.58698493
28TAOK21.57856084
29JAK31.57677605
30IKBKB1.56949557
31STK101.51860166
32KIT1.46240990
33IRAK41.39536475
34ERBB31.37325756
35EPHA31.25317343
36CSK1.22374658
37ZAK1.22211379
38EPHA21.21686685
39CAMK1D1.20225367
40PAK41.18945442
41LATS21.18314473
42CHUK1.17857435
43ACVR1B1.13242856
44PTK61.10453904
45CDK61.09992932
46MOS1.09085925
47MAP3K101.07438020
48FLT31.05980849
49IKBKE1.05422840
50STK41.04089176
51SIK11.01179616
52RIPK41.00739418
53ARAF0.99170624
54IRAK30.98952795
55IRAK10.98652635
56PIM10.98504897
57PDGFRB0.96898149
58MET0.95772481
59NME20.94467572
60NEK20.94102596
61CSF1R0.93829656
62EIF2AK20.93745826
63FGFR30.91860260
64PAK20.91615675
65MAP3K50.90272576
66MAP3K30.89818395
67TESK10.89654245
68ABL20.88791948
69PIK3CG0.88645428
70PIM20.87413313
71IRAK20.86215176
72HCK0.84369525
73LRRK20.84215044
74MAPK70.80992728
75FGR0.80355072
76MAP3K80.80032955
77PLK20.79413440
78EPHB20.78497214
79ZAP700.75524500
80FGFR40.73016101
81STK38L0.72244560
82MELK0.70147938
83ERBB40.67755433
84MARK30.67447886
85MAP3K10.66775794
86MAP2K30.65411698
87ADRBK20.64756743
88JAK20.63422150
89YES10.62629159
90NUAK10.61391406
91FGFR10.60386536
92EGFR0.59530043
93INSR0.59241992
94PTK20.59093567
95MAP3K130.57552424
96MTOR0.55482363
97TGFBR10.54061999
98ABL10.53679499
99TTK0.52812941
100RPS6KA20.52314496
101DMPK0.51059582
102LCK0.51047162
103FRK0.50006331
104GSK3A0.47633963
105MST1R0.46940572
106RPS6KC10.45997239
107RPS6KL10.45997239
108SYK0.44669522
109LYN0.44215677
110EPHB10.43734903
111CDK40.43558137
112BMPR20.43306125
113TAOK10.42619003
114FER0.42467307
115TEC0.41834249
116MATK0.41383731
117MAP3K60.39800352
118EIF2AK30.39738087
119DAPK30.38902422
120IGF1R0.38386581
121MAP3K120.37680773
122PTK2B0.37641590
123MAPKAPK20.36939032
124CLK10.36617193
125DYRK30.36336945
126ROCK20.35015895
127KSR20.34134686
128PRKD20.33869720
129AURKB0.31718064
130BTK0.31602775
131ALK0.31592382
132SGK30.30911154
133PLK30.30645579
134PRKG20.29850910
135ATR0.29756422

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.02261992
2Malaria_Homo sapiens_hsa051442.47804481
3Leishmaniasis_Homo sapiens_hsa051402.43592292
4Lysosome_Homo sapiens_hsa041422.05790899
5Legionellosis_Homo sapiens_hsa051342.05602443
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04206147
7ECM-receptor interaction_Homo sapiens_hsa045121.98031171
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.91946134
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.88178706
10Osteoclast differentiation_Homo sapiens_hsa043801.87033598
11Pertussis_Homo sapiens_hsa051331.82487626
12Phagosome_Homo sapiens_hsa041451.81655109
13Tuberculosis_Homo sapiens_hsa051521.73060825
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67252991
15Antigen processing and presentation_Homo sapiens_hsa046121.67000123
16Toxoplasmosis_Homo sapiens_hsa051451.64692235
17TNF signaling pathway_Homo sapiens_hsa046681.60660232
18Measles_Homo sapiens_hsa051621.56826243
19Graft-versus-host disease_Homo sapiens_hsa053321.54454740
20Apoptosis_Homo sapiens_hsa042101.53464561
21Focal adhesion_Homo sapiens_hsa045101.53403092
22Amoebiasis_Homo sapiens_hsa051461.52915832
23Viral myocarditis_Homo sapiens_hsa054161.50721216
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49967425
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44942041
26Proteoglycans in cancer_Homo sapiens_hsa052051.43797219
27Other glycan degradation_Homo sapiens_hsa005111.39658656
28Small cell lung cancer_Homo sapiens_hsa052221.39434101
29Adherens junction_Homo sapiens_hsa045201.38751677
30Shigellosis_Homo sapiens_hsa051311.38228955
31Influenza A_Homo sapiens_hsa051641.36577387
32Salmonella infection_Homo sapiens_hsa051321.35011874
33Complement and coagulation cascades_Homo sapiens_hsa046101.33270238
34Allograft rejection_Homo sapiens_hsa053301.31002203
35Rheumatoid arthritis_Homo sapiens_hsa053231.30291619
36MicroRNAs in cancer_Homo sapiens_hsa052061.25367188
37Herpes simplex infection_Homo sapiens_hsa051681.22742997
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19389572
39Systemic lupus erythematosus_Homo sapiens_hsa053221.17620866
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17601587
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16766394
42TGF-beta signaling pathway_Homo sapiens_hsa043501.16716205
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16267138
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.15286520
45p53 signaling pathway_Homo sapiens_hsa041151.15168360
46One carbon pool by folate_Homo sapiens_hsa006701.14699382
47Chronic myeloid leukemia_Homo sapiens_hsa052201.12879570
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10714712
49* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10426290
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.07179916
51Viral carcinogenesis_Homo sapiens_hsa052031.05421722
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05309675
53Hepatitis B_Homo sapiens_hsa051611.04720206
54Prion diseases_Homo sapiens_hsa050200.97595048
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97434424
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94757085
57Caffeine metabolism_Homo sapiens_hsa002320.94035211
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.90237789
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86900043
60HTLV-I infection_Homo sapiens_hsa051660.85385816
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84649574
62Pancreatic cancer_Homo sapiens_hsa052120.82775995
63Asthma_Homo sapiens_hsa053100.82368585
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81015530
65B cell receptor signaling pathway_Homo sapiens_hsa046620.77670520
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77366435
67HIF-1 signaling pathway_Homo sapiens_hsa040660.75310637
68Hematopoietic cell lineage_Homo sapiens_hsa046400.75170812
69Chemokine signaling pathway_Homo sapiens_hsa040620.75075033
70Melanoma_Homo sapiens_hsa052180.74842267
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74274845
72Hippo signaling pathway_Homo sapiens_hsa043900.73858637
73Renal cell carcinoma_Homo sapiens_hsa052110.73679408
74Hepatitis C_Homo sapiens_hsa051600.72631055
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71385962
76Epstein-Barr virus infection_Homo sapiens_hsa051690.69388974
77Bladder cancer_Homo sapiens_hsa052190.69082323
78Prostate cancer_Homo sapiens_hsa052150.68577274
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66730664
80Protein digestion and absorption_Homo sapiens_hsa049740.66013710
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.65579930
82Platelet activation_Homo sapiens_hsa046110.65399880
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65105789
84Notch signaling pathway_Homo sapiens_hsa043300.64628631
85African trypanosomiasis_Homo sapiens_hsa051430.64602915
86Sphingolipid metabolism_Homo sapiens_hsa006000.63703003
87Pathways in cancer_Homo sapiens_hsa052000.61910218
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.58654151
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.58419250
90Acute myeloid leukemia_Homo sapiens_hsa052210.55031634
91Cell cycle_Homo sapiens_hsa041100.54509614
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52727667
93Autoimmune thyroid disease_Homo sapiens_hsa053200.51198118
94Dilated cardiomyopathy_Homo sapiens_hsa054140.51102083
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.50395458
96Dorso-ventral axis formation_Homo sapiens_hsa043200.50375613
97Renin-angiotensin system_Homo sapiens_hsa046140.49775673
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48857059
99Basal cell carcinoma_Homo sapiens_hsa052170.48215486
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.47662065
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47060631
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47013221
103Colorectal cancer_Homo sapiens_hsa052100.45842852
104Rap1 signaling pathway_Homo sapiens_hsa040150.45730626
105VEGF signaling pathway_Homo sapiens_hsa043700.44474356
106T cell receptor signaling pathway_Homo sapiens_hsa046600.44154979
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43305829
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42723627
109mTOR signaling pathway_Homo sapiens_hsa041500.42513806
110Endocytosis_Homo sapiens_hsa041440.42385945
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40762731
112Prolactin signaling pathway_Homo sapiens_hsa049170.40206759
113Type I diabetes mellitus_Homo sapiens_hsa049400.39786215
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38692709

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