DSG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.69468365
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.42444503
3intermediate filament organization (GO:0045109)7.21853512
4keratinocyte differentiation (GO:0030216)7.11824047
5peptide cross-linking (GO:0018149)6.91815400
6keratinocyte proliferation (GO:0043616)6.79312982
7multicellular organismal water homeostasis (GO:0050891)6.64812902
8epidermis development (GO:0008544)6.33042573
9keratinocyte development (GO:0003334)6.30065718
10negative regulation of keratinocyte proliferation (GO:0010839)6.10332869
11cell-substrate junction assembly (GO:0007044)5.93213781
12gap junction assembly (GO:0016264)5.51230494
13epidermal cell differentiation (GO:0009913)5.48414559
14water homeostasis (GO:0030104)5.45476064
15polarized epithelial cell differentiation (GO:0030859)5.37454628
16ectoderm development (GO:0007398)5.23420428
17surfactant homeostasis (GO:0043129)5.22811014
18intermediate filament cytoskeleton organization (GO:0045104)4.51911500
19chemical homeostasis within a tissue (GO:0048875)4.49735665
20atrioventricular valve morphogenesis (GO:0003181)4.36303700
21intermediate filament-based process (GO:0045103)4.35516315
22regulation of keratinocyte proliferation (GO:0010837)4.34857268
23skin morphogenesis (GO:0043589)4.31279923
24negative regulation of cell fate specification (GO:0009996)4.10641048
25epithelial cell differentiation involved in prostate gland development (GO:0060742)4.06736175
26long-chain fatty acid biosynthetic process (GO:0042759)3.95489877
27regulation of hair follicle development (GO:0051797)3.93996095
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.82774095
29skin development (GO:0043588)3.79759827
30cell communication involved in cardiac conduction (GO:0086065)3.72050645
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.69887364
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.57176800
33positive regulation of epidermis development (GO:0045684)3.53147823
34negative regulation of cell fate commitment (GO:0010454)3.50498706
35phosphatidylserine acyl-chain remodeling (GO:0036150)3.37670241
36mesodermal cell differentiation (GO:0048333)3.37348268
37regulation of hair cycle (GO:0042634)3.35261747
38negative regulation of interferon-gamma production (GO:0032689)3.34275089
39lateral sprouting from an epithelium (GO:0060601)3.33947537
40cell adhesion mediated by integrin (GO:0033627)3.33625181
41positive regulation of hair cycle (GO:0042635)3.33178454
42positive regulation of hair follicle development (GO:0051798)3.33178454
43positive regulation of epidermal cell differentiation (GO:0045606)3.32291957
44cardiac conduction (GO:0061337)3.32139637
45hair follicle morphogenesis (GO:0031069)3.27976773
46gland morphogenesis (GO:0022612)3.25829594
47odontogenesis (GO:0042476)3.25057758
48epithelium development (GO:0060429)3.24857718
49regulation of keratinocyte differentiation (GO:0045616)3.24263907
50odontogenesis of dentin-containing tooth (GO:0042475)3.23820540
51G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.19985726
52phosphatidylinositol acyl-chain remodeling (GO:0036149)3.19560658
53regulation of epidermis development (GO:0045682)3.18625414
54detection of bacterium (GO:0016045)3.10792032
55establishment of tissue polarity (GO:0007164)3.10592212
56establishment of planar polarity (GO:0001736)3.10592212
57renal system development (GO:0072001)3.10511015
58regulation of cardioblast differentiation (GO:0051890)3.09685973
59interferon-gamma secretion (GO:0072643)3.07682742
60one-carbon compound transport (GO:0019755)3.03023382
61hair cycle process (GO:0022405)3.02196763
62molting cycle process (GO:0022404)3.02196763
63cardiac muscle cell action potential involved in contraction (GO:0086002)3.01775132
64cardiac right ventricle morphogenesis (GO:0003215)3.00733057
65positive regulation of vesicle fusion (GO:0031340)2.99350221
66adhesion of symbiont to host cell (GO:0044650)2.98337623
67virion attachment to host cell (GO:0019062)2.98337623
68regulation of ruffle assembly (GO:1900027)2.97306429
69regulation of phospholipase A2 activity (GO:0032429)2.94774618
70ventricular cardiac muscle cell action potential (GO:0086005)2.92395059
71cardiac muscle cell action potential (GO:0086001)2.92240975
72regulation of transforming growth factor beta2 production (GO:0032909)2.90163431
73negative regulation of epidermis development (GO:0045683)2.89863772
74lipoxygenase pathway (GO:0019372)2.86254428
75eyelid development in camera-type eye (GO:0061029)2.85157426
76regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.84410992
77phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.84127404
78lymph vessel development (GO:0001945)2.75932270
79hypotonic response (GO:0006971)2.73878949
80regulation of natural killer cell differentiation (GO:0032823)2.73325898
81heart valve morphogenesis (GO:0003179)2.72652987
82non-canonical Wnt signaling pathway (GO:0035567)2.71835275
83hair follicle development (GO:0001942)2.71523341
84endodermal cell differentiation (GO:0035987)2.71363191
85phosphatidylcholine acyl-chain remodeling (GO:0036151)2.70799879
86epithelial cell-cell adhesion (GO:0090136)2.70276307
87phosphatidylserine metabolic process (GO:0006658)2.70230675
88negative regulation of chondrocyte differentiation (GO:0032331)2.70186274
89regulation of epidermal cell differentiation (GO:0045604)2.69120598
90positive regulation of odontogenesis (GO:0042482)2.67912206
91detection of other organism (GO:0098543)2.66522187
92wound healing (GO:0042060)2.65874266
93linoleic acid metabolic process (GO:0043651)2.64401909
94negative regulation of epidermal cell differentiation (GO:0045605)2.64040677
95genitalia morphogenesis (GO:0035112)2.62508178
96ephrin receptor signaling pathway (GO:0048013)2.62370565
97lung lobe morphogenesis (GO:0060463)2.61626179
98epithelial cell proliferation (GO:0050673)2.61300029
99positive regulation of monocyte chemotaxis (GO:0090026)2.61016499
100regulation of cell fate specification (GO:0042659)2.59921059
101membrane budding (GO:0006900)2.59637145
102cell surface receptor signaling pathway involved in heart development (GO:0061311)2.59148527
103viral transcription (GO:0019083)2.53202439
104regulation of heart rate by cardiac conduction (GO:0086091)2.51514097
105cell junction organization (GO:0034330)2.51144283
106regulation of hypersensitivity (GO:0002883)2.50802851
107outer ear morphogenesis (GO:0042473)2.49703228
108renal filtration (GO:0097205)2.48885097
109positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.48850412
110sequestering of metal ion (GO:0051238)2.48383120
111negative regulation of cell aging (GO:0090344)2.46757395
112negative regulation of acute inflammatory response (GO:0002674)2.46744480
113cellular response to vitamin D (GO:0071305)2.46333667
114L-serine transport (GO:0015825)2.45560275
115dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45485387
116regulation of protein localization to cell surface (GO:2000008)2.44957424
117intestinal epithelial cell development (GO:0060576)2.44460314
118cytoskeletal anchoring at plasma membrane (GO:0007016)2.43303081
119face development (GO:0060324)2.43132462
120limb bud formation (GO:0060174)2.42205678
121Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.42059882
122embryonic viscerocranium morphogenesis (GO:0048703)2.40406797
123cell junction assembly (GO:0034329)2.40217206
124tooth mineralization (GO:0034505)2.39792168
125translational termination (GO:0006415)2.38763890
126morphogenesis of embryonic epithelium (GO:0016331)2.38365483
127positive regulation of keratinocyte differentiation (GO:0045618)2.37573473
128regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.37499080
129hemidesmosome assembly (GO:0031581)17.8823340
130desmosome organization (GO:0002934)14.1872119
131keratinization (GO:0031424)12.3693101
132molting cycle (GO:0042303)11.3024688
133hair cycle (GO:0042633)11.3024688
134establishment of skin barrier (GO:0061436)10.6661576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.10729024
2* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.85758914
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82774669
4P63_26484246_Chip-Seq_KERATINOCYTES_Human2.61427190
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44554584
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42561188
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.19833431
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.06724635
9ZNF263_19887448_ChIP-Seq_K562_Human2.06441845
10TP63_17297297_ChIP-ChIP_HaCaT_Human17.1864720
11* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99571150
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99571150
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.70559090
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.60397495
15AR_21572438_ChIP-Seq_LNCaP_Human1.52093598
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47448742
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40346732
18* CJUN_26792858_Chip-Seq_BT549_Human1.35273766
19SOX2_20726797_ChIP-Seq_SW620_Human1.30957769
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.29412199
21KLF5_25053715_ChIP-Seq_YYC3_Human1.28653938
22TP63_23658742_ChIP-Seq_EP156T_Human1.27215559
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25817524
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21955356
25TP53_18474530_ChIP-ChIP_U2OS_Human1.21390768
26EGR1_19032775_ChIP-ChIP_M12_Human1.20776405
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.17688707
28RACK7_27058665_Chip-Seq_MCF-7_Human1.12171831
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09880664
30TP63_22573176_ChIP-Seq_HFKS_Human1.09213500
31UBF1/2_26484160_Chip-Seq_HMECs_Human1.08564143
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08301052
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05704768
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.03557621
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03476466
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02618177
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00143836
38SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98500613
39EZH2_27304074_Chip-Seq_ESCs_Mouse0.98423550
40AHR_22903824_ChIP-Seq_MCF-7_Human0.98281023
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96147191
42JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95037340
43RXR_22108803_ChIP-Seq_LS180_Human0.95035601
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94822871
45EED_16625203_ChIP-ChIP_MESCs_Mouse0.93238747
46EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93050712
47RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93050712
48ATF3_27146783_Chip-Seq_COLON_Human0.92371073
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91586956
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91522871
51BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90212392
52TP53_16413492_ChIP-PET_HCT116_Human0.89469909
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88089016
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87851836
55RNF2_27304074_Chip-Seq_ESCs_Mouse0.87480925
56EZH2_27294783_Chip-Seq_ESCs_Mouse0.86736616
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86388052
58* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85434286
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85124710
60GATA3_24758297_ChIP-Seq_MCF-7_Human0.84223036
61* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83713339
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83048200
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82011205
64PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79358408
65CDX2_20551321_ChIP-Seq_CACO-2_Human0.79021279
66GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78551719
67ERG_21242973_ChIP-ChIP_JURKAT_Human0.78423901
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77201511
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76251897
70ARNT_22903824_ChIP-Seq_MCF-7_Human0.76217530
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75690984
72GATA4_25053715_ChIP-Seq_YYC3_Human0.75519026
73JARID2_20064375_ChIP-Seq_MESCs_Mouse0.75365702
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73659089
75GATA6_25053715_ChIP-Seq_YYC3_Human0.73346202
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73008023
77DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72316635
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72156793
79RBPJ_21746931_ChIP-Seq_IB4_Human0.72017937
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.70704046
81CTCF_27219007_Chip-Seq_Bcells_Human0.70010076
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.69943116
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.68963983
84SMAD3_21741376_ChIP-Seq_HESCs_Human0.68797880
85BCAT_22108803_ChIP-Seq_LS180_Human0.68545333
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.67878109
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67861279
88ESR1_20079471_ChIP-ChIP_T-47D_Human0.67345000
89P300_27058665_Chip-Seq_ZR-75-30cells_Human0.65098803
90MTF2_20144788_ChIP-Seq_MESCs_Mouse0.64608817
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.64420609
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.64139185
93P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.63957450
94ETV1_20927104_ChIP-Seq_GIST48_Human0.63868701
95RING1B_27294783_Chip-Seq_ESCs_Mouse0.63835602
96KDM2B_26808549_Chip-Seq_K562_Human0.63831131
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.62687091
98RING1B_27294783_Chip-Seq_NPCs_Mouse0.62510553
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.62153914
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.61988351
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.61966368
102* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61540657
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60177174
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.58937280
105LXR_22292898_ChIP-Seq_THP-1_Human0.58857111
106SOX2_27498859_Chip-Seq_STOMACH_Mouse0.58266198
107PCGF2_27294783_Chip-Seq_NPCs_Mouse0.58244933
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.57136439
109CBX2_22325352_ChIP-Seq_293T-Rex_Human0.56953679
110ELK4_26923725_Chip-Seq_MESODERM_Mouse0.56203188
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.56068583
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.55575674
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55084151
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54999692
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.54377425
116HNFA_21074721_ChIP-Seq_CACO-2_Human0.54254716
117* CDX2_22108803_ChIP-Seq_LS180_Human0.52920487
118CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.51829427
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.51229407
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.50795834
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.50093826
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.48331108
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.48331108
124BRD4_25478319_ChIP-Seq_HGPS_Human0.47533314
125PHF8_20622853_ChIP-Seq_HELA_Human0.47364894
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46897392
127SMAD4_21799915_ChIP-Seq_A2780_Human0.45501950
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44795725
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.44482688
130TBX20_22328084_ChIP-Seq_HEART_Mouse0.44121987
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.44121987
132E2F1_20622854_ChIP-Seq_HELA_Human0.43916238
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.42998192
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.42505237
135TBL1_22424771_ChIP-Seq_293T_Human0.41720211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.08718612
2MP0002796_impaired_skin_barrier5.96611882
3MP0005275_abnormal_skin_tensile4.54503006
4MP0002254_reproductive_system_inflammat4.47563976
5MP0000383_abnormal_hair_follicle4.21767051
6MP0004381_abnormal_hair_follicle4.08071739
7MP0010234_abnormal_vibrissa_follicle4.00848592
8MP0005501_abnormal_skin_physiology3.80693957
9MP0010678_abnormal_skin_adnexa3.61835518
10MP0002060_abnormal_skin_morphology3.57550349
11MP0000467_abnormal_esophagus_morphology3.46274041
12MP0003941_abnormal_skin_development3.40501373
13* MP0001216_abnormal_epidermal_layer3.21481661
14MP0002098_abnormal_vibrissa_morphology3.20477871
15MP0003705_abnormal_hypodermis_morpholog3.08067724
16MP0000647_abnormal_sebaceous_gland3.06820712
17MP0000762_abnormal_tongue_morphology3.02141730
18MP0003453_abnormal_keratinocyte_physiol3.00739478
19MP0010771_integument_phenotype2.76527837
20MP0002234_abnormal_pharynx_morphology2.61450217
21* MP0000377_abnormal_hair_follicle2.44362789
22* MP0000427_abnormal_hair_cycle2.40380176
23MP0004885_abnormal_endolymph2.28189777
24MP0003136_yellow_coat_color2.25048734
25MP0004947_skin_inflammation2.19230723
26MP0001346_abnormal_lacrimal_gland2.13781241
27MP0001849_ear_inflammation2.12346862
28MP0004264_abnormal_extraembryonic_tissu2.09219066
29MP0000566_synostosis2.01910079
30MP0005409_darkened_coat_color1.81420509
31* MP0003566_abnormal_cell_adhesion1.61097418
32MP0001191_abnormal_skin_condition1.57328856
33* MP0009931_abnormal_skin_appearance1.54122632
34MP0008789_abnormal_olfactory_epithelium1.53559067
35MP0001243_abnormal_dermal_layer1.45039615
36MP0009053_abnormal_anal_canal1.38347029
37MP0003878_abnormal_ear_physiology1.36296819
38MP0005377_hearing/vestibular/ear_phenot1.36296819
39* MP0000367_abnormal_coat/_hair1.30012445
40MP0010030_abnormal_orbit_morphology1.27178612
41MP0009379_abnormal_foot_pigmentation1.25349159
42MP0005023_abnormal_wound_healing1.20886138
43MP0005499_abnormal_olfactory_system1.19691899
44MP0005394_taste/olfaction_phenotype1.19691899
45MP0001340_abnormal_eyelid_morphology1.05933360
46MP0000538_abnormal_urinary_bladder1.03554391
47MP0010352_gastrointestinal_tract_polyps1.00062833
48MP0003755_abnormal_palate_morphology0.98851095
49MP0002282_abnormal_trachea_morphology0.97724956
50MP0000537_abnormal_urethra_morphology0.97179542
51MP0000627_abnormal_mammary_gland0.94002369
52MP0002877_abnormal_melanocyte_morpholog0.93285326
53MP0004272_abnormal_basement_membrane0.92849811
54MP0009780_abnormal_chondrocyte_physiolo0.92408290
55* MP0001851_eye_inflammation0.91421014
56MP0004185_abnormal_adipocyte_glucose0.88794949
57MP0002233_abnormal_nose_morphology0.87005319
58MP0000465_gastrointestinal_hemorrhage0.84856047
59MP0002249_abnormal_larynx_morphology0.82188494
60MP0002095_abnormal_skin_pigmentation0.81521622
61MP0002009_preneoplasia0.79135718
62MP0002177_abnormal_outer_ear0.78249399
63MP0005451_abnormal_body_composition0.72421633
64MP0009384_cardiac_valve_regurgitation0.72377206
65MP0001188_hyperpigmentation0.69407411
66MP0003315_abnormal_perineum_morphology0.68701421
67MP0004043_abnormal_pH_regulation0.65629965
68MP0005257_abnormal_intraocular_pressure0.63324066
69MP0000569_abnormal_digit_pigmentation0.62378430
70MP0008260_abnormal_autophagy0.58005764
71MP0005076_abnormal_cell_differentiation0.57649148
72MP0004782_abnormal_surfactant_physiolog0.57087812
73MP0003011_delayed_dark_adaptation0.55926271
74MP0000678_abnormal_parathyroid_gland0.54837904
75MP0000432_abnormal_head_morphology0.54285979
76MP0002111_abnormal_tail_morphology0.52186709
77MP0005508_abnormal_skeleton_morphology0.50874046
78MP0005248_abnormal_Harderian_gland0.50265841
79MP0001784_abnormal_fluid_regulation0.49015039
80MP0005075_abnormal_melanosome_morpholog0.48808006
81MP0000462_abnormal_digestive_system0.46868945
82MP0003385_abnormal_body_wall0.46078309
83MP0009250_abnormal_appendicular_skeleto0.45734909
84MP0008438_abnormal_cutaneous_collagen0.44687196
85MP0000613_abnormal_salivary_gland0.43922286
86MP0005367_renal/urinary_system_phenotyp0.41472718
87MP0000516_abnormal_urinary_system0.41472718
88MP0000470_abnormal_stomach_morphology0.41395323
89MP0003937_abnormal_limbs/digits/tail_de0.40163219
90MP0003638_abnormal_response/metabolism_0.39981211
91MP0005360_urolithiasis0.37387628
92MP0000858_altered_metastatic_potential0.37282254
93MP0002896_abnormal_bone_mineralization0.37016762
94MP0003300_gastrointestinal_ulcer0.36468087
95MP0003935_abnormal_craniofacial_develop0.36221939
96* MP0005193_abnormal_anterior_eye0.35733506
97MP0003191_abnormal_cellular_cholesterol0.35096223
98MP0002006_tumorigenesis0.33397826
99MP0004197_abnormal_fetal_growth/weight/0.32557074
100MP0002109_abnormal_limb_morphology0.31710098
101MP0010155_abnormal_intestine_physiology0.31385550
102MP0000049_abnormal_middle_ear0.31241745
103MP0001765_abnormal_ion_homeostasis0.29857038
104MP0000428_abnormal_craniofacial_morphol0.28329887
105MP0004019_abnormal_vitamin_homeostasis0.27574949
106MP0001299_abnormal_eye_distance/0.26908108
107MP0002697_abnormal_eye_size0.26524851
108MP0005197_abnormal_uvea_morphology0.25513110
109MP0003950_abnormal_plasma_membrane0.25324765
110MP0005388_respiratory_system_phenotype0.24821375
111MP0002133_abnormal_respiratory_system0.24821375
112MP0003045_fibrosis0.24464892
113MP0001286_abnormal_eye_development0.24137404
114MP0005390_skeleton_phenotype0.23769443
115MP0003448_altered_tumor_morphology0.23158426
116MP0002166_altered_tumor_susceptibility0.23021894
117MP0002089_abnormal_postnatal_growth/wei0.22950683
118MP0001270_distended_abdomen0.21818526
119MP0006138_congestive_heart_failure0.19369373
120MP0001177_atelectasis0.18822168
121MP0003828_pulmonary_edema0.17042200
122MP0004134_abnormal_chest_morphology0.16519579
123MP0001186_pigmentation_phenotype0.15628388
124MP0001984_abnormal_olfaction0.14231261
125MP0000003_abnormal_adipose_tissue0.14006891

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)9.20336285
2Fragile nails (HP:0001808)9.04866440
3Onycholysis (HP:0001806)8.58844010
4Plantar hyperkeratosis (HP:0007556)8.39585098
5Abnormality of nail color (HP:0100643)7.60346647
6Thick nail (HP:0001805)7.58928614
7Hypotrichosis (HP:0001006)6.62661340
8Pili torti (HP:0003777)6.38997850
9Palmoplantar hyperkeratosis (HP:0000972)6.32009766
10Atrophic scars (HP:0001075)6.17907345
11Woolly hair (HP:0002224)6.02786912
12Palmar hyperkeratosis (HP:0010765)5.97295173
13Nail dystrophy (HP:0008404)5.49151105
14Right ventricular cardiomyopathy (HP:0011663)5.31164347
15Alopecia of scalp (HP:0002293)5.17959068
16Abnormal blistering of the skin (HP:0008066)5.15076657
17Ridged nail (HP:0001807)4.57037793
18Increased IgE level (HP:0003212)4.37310174
19Aplasia cutis congenita (HP:0001057)4.34580031
20Abnormal hair laboratory examination (HP:0003328)3.93142532
21Parakeratosis (HP:0001036)3.59845266
22Follicular hyperkeratosis (HP:0007502)3.56924123
23Erythema (HP:0010783)3.50738086
24Lip pit (HP:0100267)3.47125588
25Fatigable weakness (HP:0003473)3.35501555
26Abnormality of the neuromuscular junction (HP:0003398)3.35501555
27Ectropion (HP:0000656)3.33669324
28Congenital ichthyosiform erythroderma (HP:0007431)3.33585191
29Sparse eyelashes (HP:0000653)3.33360417
30Fragile skin (HP:0001030)3.32539465
31Oral leukoplakia (HP:0002745)3.16504200
32Esophageal atresia (HP:0002032)3.12563774
33Abnormality of placental membranes (HP:0011409)3.11880130
34Amniotic constriction ring (HP:0009775)3.11880130
35Hypoplasia of dental enamel (HP:0006297)3.08215538
36Natal tooth (HP:0000695)2.99075209
37Erythroderma (HP:0001019)2.92717354
38Advanced eruption of teeth (HP:0006288)2.90459529
39Pterygium (HP:0001059)2.78716984
40Absent hair (HP:0002298)2.70583301
41Conjunctival hamartoma (HP:0100780)2.63237205
42Palmoplantar keratoderma (HP:0000982)2.61510935
43Distal lower limb muscle weakness (HP:0009053)2.59626229
44Anonychia (HP:0001798)2.59195516
45Corneal erosion (HP:0200020)2.55094873
46Sparse scalp hair (HP:0002209)2.55054983
47Hypohidrosis (HP:0000966)2.54803764
48Amelogenesis imperfecta (HP:0000705)2.54343180
49Hyperhidrosis (HP:0000975)2.52257472
50Curly hair (HP:0002212)2.50551310
51Ventricular tachycardia (HP:0004756)2.48809180
52Blepharitis (HP:0000498)2.42469465
53Laryngomalacia (HP:0001601)2.37549175
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.26293944
55Hypodontia (HP:0000668)2.25810353
56Acanthosis nigricans (HP:0000956)2.23569968
57Gangrene (HP:0100758)2.21987586
58Carious teeth (HP:0000670)2.21639656
59Labial hypoplasia (HP:0000066)2.14832823
60Furrowed tongue (HP:0000221)2.12804093
61Increased connective tissue (HP:0009025)2.09989156
62Concave nail (HP:0001598)2.07844920
63Corneal dystrophy (HP:0001131)2.07491433
64Abnormality of the fingernails (HP:0001231)2.07443708
65Pruritus (HP:0000989)2.04141902
66Xerostomia (HP:0000217)2.03662367
67Down-sloping shoulders (HP:0200021)2.03132328
68Duplicated collecting system (HP:0000081)2.00191141
69Hyporeflexia of lower limbs (HP:0002600)1.98087702
70Ureteral stenosis (HP:0000071)1.97975041
71Slow-growing hair (HP:0002217)1.96364923
72Abnormality of hair growth rate (HP:0011363)1.96364923
73Hypoplastic female external genitalia (HP:0012815)1.95878028
74Skin ulcer (HP:0200042)1.95249269
75Split foot (HP:0001839)1.93630902
76Pustule (HP:0200039)1.92246441
77Multifactorial inheritance (HP:0001426)1.90118475
78Breast hypoplasia (HP:0003187)1.87165085
79Popliteal pterygium (HP:0009756)1.86627853
80Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.85426456
81Autoamputation (HP:0001218)1.82437626
82Septate vagina (HP:0001153)1.82374336
83Ureteral obstruction (HP:0006000)1.80398279
84Conical tooth (HP:0000698)1.79477264
85Congenital, generalized hypertrichosis (HP:0004540)1.75723429
86Abnormality of secondary sexual hair (HP:0009888)1.72521980
87Abnormality of the axillary hair (HP:0100134)1.72521980
88Nasolacrimal duct obstruction (HP:0000579)1.71875070
89Squamous cell carcinoma (HP:0002860)1.71566371
90Aplasia involving bones of the extremities (HP:0009825)1.71502526
91Aplasia involving bones of the upper limbs (HP:0009823)1.71502526
92Aplasia of the phalanges of the hand (HP:0009802)1.71502526
93Abnormality of the renal collecting system (HP:0004742)1.69212654
94Premature loss of primary teeth (HP:0006323)1.66538930
95Abnormality of the dental root (HP:0006486)1.65987377
96Taurodontia (HP:0000679)1.65987377
97Abnormality of permanent molar morphology (HP:0011071)1.65987377
98Abnormality of the gastric mucosa (HP:0004295)1.65487203
99Dehydration (HP:0001944)1.65236642
100Unilateral renal agenesis (HP:0000122)1.63265849
101Fine hair (HP:0002213)1.62585583
102Cheilitis (HP:0100825)1.62553424
103Epidermoid cyst (HP:0200040)1.62044333
104Oligodontia (HP:0000677)1.61382912
105Hypoplastic labia majora (HP:0000059)1.58923084
106Depressed nasal tip (HP:0000437)1.56407383
107Gastrointestinal atresia (HP:0002589)1.55542116
108Dry hair (HP:0011359)1.55392002
109Abnormality of molar morphology (HP:0011070)1.54277569
110Abnormality of molar (HP:0011077)1.54277569
111Selective tooth agenesis (HP:0001592)1.53132698
112Brittle hair (HP:0002299)1.50092811
113Abnormality of the salivary glands (HP:0010286)1.50005090
114Ventricular fibrillation (HP:0001663)1.49868793
115Hypoplasia of the uterus (HP:0000013)1.49109575
116Absent eyebrow (HP:0002223)1.48391162
117Abnormality of the labia majora (HP:0012881)1.47328666
118Hamartoma of the eye (HP:0010568)1.47306422
119Abnormality of the distal phalanges of the toes (HP:0010182)1.46075637
120Ankyloglossia (HP:0010296)1.41562893
121Distal lower limb amyotrophy (HP:0008944)1.41226093
122Absent eyelashes (HP:0000561)1.40966596
123Neonatal onset (HP:0003623)1.35070193
124Abnormality of the nasal septum (HP:0000419)1.34488713
125Skin pits (HP:0100276)1.34122067
126Obstructive sleep apnea (HP:0002870)1.32315401
127Recurrent corneal erosions (HP:0000495)1.31256655
128Pyloric stenosis (HP:0002021)1.28596218
129Round ear (HP:0100830)1.25331863
130Hypergammaglobulinemia (HP:0010702)1.24615417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR14.85295087
2MST1R4.38303119
3EPHA24.20281716
4FER4.01865172
5MAP3K33.89678325
6EPHB23.77304246
7MAPKAPK33.32242132
8LATS13.14111767
9MST42.62759886
10ERN12.52025737
11TRPM72.48274332
12NTRK12.35125787
13ERBB32.29818055
14MAP3K22.27727981
15ARAF2.27468745
16EPHA32.22641339
17EPHB12.21731934
18FGFR22.16103717
19STK241.99080044
20RPS6KB21.95374641
21TRIB31.89174690
22FLT31.84989458
23CDK121.71897286
24LRRK21.59549776
25BCR1.54636618
26RPS6KA41.50421715
27FGFR41.40556437
28FGFR11.40032052
29MET1.34773896
30NME11.33630009
31PTK61.29087989
32FGFR31.27424786
33PIM21.17864247
34PBK1.16148716
35SIK11.15879517
36TTN1.14785526
37PTK21.13683976
38PIK3CG1.13359475
39MAP3K141.13343462
40MAP3K11.11491547
41MAPKAPK51.08269189
42LMTK21.07191561
43LATS21.01759142
44CDK60.99830590
45FRK0.96031920
46TYK20.95331852
47CASK0.94563593
48DYRK1B0.87495139
49MAP2K60.85654691
50EEF2K0.85535268
51STK100.84247396
52MAPKAPK20.83214781
53SGK2230.82506803
54SGK4940.82506803
55NTRK20.81100534
56STK38L0.80639952
57TAOK10.79865261
58STK380.77292258
59ERBB20.77083261
60TGFBR20.76162950
61KSR20.75326694
62MAP2K10.74802831
63MAP3K120.74273304
64BMX0.73422061
65RIPK10.71548927
66RPS6KA10.70375801
67WNK10.67646621
68STK30.67434159
69MAP3K110.67122835
70PKN20.66291987
71DMPK0.65232822
72MAP2K20.64923640
73GRK10.64909364
74ADRBK10.63332057
75GRK60.61771730
76MAP3K70.61439681
77MAP3K90.61236506
78ILK0.60979043
79BMPR20.59649298
80MAPK150.59463679
81HIPK20.59375414
82PDGFRA0.56885751
83CDK190.55954258
84PRKD10.55861341
85PAK40.48869682
86MAP3K130.48043080
87IKBKB0.47524397
88CDC42BPA0.47265399
89PRKD20.45257355
90IKBKE0.43916728
91NLK0.43303187
92RPS6KA20.43200294
93RPS6KB10.42803118
94PHKG10.42496547
95PHKG20.42496547
96OBSCN0.42139516
97PRKCE0.41259404
98DDR20.40987794
99GSK3A0.40608433
100ADRBK20.40594820
101NEK60.40530791
102IRAK10.39801916
103CAMK1D0.39366116
104RAF10.39280230
105ROCK10.37621390
106SIK30.37422531
107MAPK70.37172367
108TESK10.36914119
109CHUK0.36746677
110CAMK1G0.36740064
111IGF1R0.35698639
112MAP3K60.35346772
113JAK30.34824604
114RET0.33740803
115BMPR1B0.32855873
116BLK0.32617066
117BRAF0.31351207
118MAPK40.30274643
119NUAK10.29779862
120MAP2K30.29188943
121ROCK20.28636409
122PRKCI0.27413283
123HCK0.26729980
124KSR10.26722184
125JAK10.26060340
126FGR0.26035952
127PIK3CA0.25505434
128EPHA40.22273894
129EIF2AK20.22164868
130SRC0.21813856
131TBK10.21118357
132SGK10.20628573
133ABL10.20405261
134ABL20.20303647
135MATK0.19896156
136TAOK30.19562175
137MAPK120.19402327
138PDGFRB0.19391135
139RPS6KC10.19111033
140MARK10.16715400

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.59398114
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.10166099
3Basal cell carcinoma_Homo sapiens_hsa052173.07887744
4Hedgehog signaling pathway_Homo sapiens_hsa043402.20872486
5Adherens junction_Homo sapiens_hsa045202.11636233
6Amoebiasis_Homo sapiens_hsa051462.02030161
7Hippo signaling pathway_Homo sapiens_hsa043901.96806728
8Proteoglycans in cancer_Homo sapiens_hsa052051.91077046
9Small cell lung cancer_Homo sapiens_hsa052221.91021206
10Ribosome_Homo sapiens_hsa030101.80257742
11Toxoplasmosis_Homo sapiens_hsa051451.78271915
12Linoleic acid metabolism_Homo sapiens_hsa005911.74548338
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.71324911
14Steroid biosynthesis_Homo sapiens_hsa001001.69571444
15Axon guidance_Homo sapiens_hsa043601.68777752
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66796703
17Focal adhesion_Homo sapiens_hsa045101.58262509
18Ovarian steroidogenesis_Homo sapiens_hsa049131.57561296
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57401782
20Melanogenesis_Homo sapiens_hsa049161.56969116
21Arachidonic acid metabolism_Homo sapiens_hsa005901.56105101
22Tight junction_Homo sapiens_hsa045301.42323968
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40260092
24Phenylalanine metabolism_Homo sapiens_hsa003601.37596542
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35638794
26Bladder cancer_Homo sapiens_hsa052191.35420561
27TGF-beta signaling pathway_Homo sapiens_hsa043501.34909543
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28114132
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27136187
30Dilated cardiomyopathy_Homo sapiens_hsa054141.21499918
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19779746
32VEGF signaling pathway_Homo sapiens_hsa043701.17108083
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15232126
34MicroRNAs in cancer_Homo sapiens_hsa052061.14366357
35Wnt signaling pathway_Homo sapiens_hsa043101.14257204
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.13334383
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08353705
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.08152211
39Phototransduction_Homo sapiens_hsa047441.07975167
40Acute myeloid leukemia_Homo sapiens_hsa052211.07930937
41Pathways in cancer_Homo sapiens_hsa052001.06858273
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05722694
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05337128
44Circadian rhythm_Homo sapiens_hsa047101.04990513
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04197771
46Notch signaling pathway_Homo sapiens_hsa043301.03458007
47p53 signaling pathway_Homo sapiens_hsa041151.03084934
48TNF signaling pathway_Homo sapiens_hsa046681.02967553
49GnRH signaling pathway_Homo sapiens_hsa049121.01105626
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01077096
51Malaria_Homo sapiens_hsa051441.00892338
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00670209
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.00174926
54Thyroid cancer_Homo sapiens_hsa052160.99256331
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99219958
56Protein digestion and absorption_Homo sapiens_hsa049740.96589283
57Fatty acid elongation_Homo sapiens_hsa000620.96362585
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95794771
59Hepatitis C_Homo sapiens_hsa051600.95468916
60Ether lipid metabolism_Homo sapiens_hsa005650.94709104
61Rap1 signaling pathway_Homo sapiens_hsa040150.94535156
62Renin secretion_Homo sapiens_hsa049240.94189500
63Chemical carcinogenesis_Homo sapiens_hsa052040.93830135
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90928172
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87912952
66Pertussis_Homo sapiens_hsa051330.87567127
67Retinol metabolism_Homo sapiens_hsa008300.87116451
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83837247
69Ras signaling pathway_Homo sapiens_hsa040140.83389347
70Glycerolipid metabolism_Homo sapiens_hsa005610.82774285
71Salivary secretion_Homo sapiens_hsa049700.82064508
72Sulfur metabolism_Homo sapiens_hsa009200.81742649
73Serotonergic synapse_Homo sapiens_hsa047260.81621174
74Endometrial cancer_Homo sapiens_hsa052130.80996137
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80912900
76Sphingolipid metabolism_Homo sapiens_hsa006000.79576585
77Histidine metabolism_Homo sapiens_hsa003400.77769356
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75910827
79Dorso-ventral axis formation_Homo sapiens_hsa043200.75032648
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74047920
81Inositol phosphate metabolism_Homo sapiens_hsa005620.73626408
82Pancreatic secretion_Homo sapiens_hsa049720.72856153
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.72708166
84Pancreatic cancer_Homo sapiens_hsa052120.72512714
85Nitrogen metabolism_Homo sapiens_hsa009100.71350342
86Glioma_Homo sapiens_hsa052140.69867633
87Platelet activation_Homo sapiens_hsa046110.69713304
88Melanoma_Homo sapiens_hsa052180.68693051
89Gastric acid secretion_Homo sapiens_hsa049710.68520740
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68353860
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68242275
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66697057
93ABC transporters_Homo sapiens_hsa020100.66670364
94Tyrosine metabolism_Homo sapiens_hsa003500.66582094
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65208152
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64888724
97Choline metabolism in cancer_Homo sapiens_hsa052310.64197783
98Mineral absorption_Homo sapiens_hsa049780.62390838
99Salmonella infection_Homo sapiens_hsa051320.61865906
100Hematopoietic cell lineage_Homo sapiens_hsa046400.61689319
101Insulin resistance_Homo sapiens_hsa049310.60852826
102Long-term depression_Homo sapiens_hsa047300.60536347
103ErbB signaling pathway_Homo sapiens_hsa040120.60291770
104Tuberculosis_Homo sapiens_hsa051520.60007534
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59088640
106Apoptosis_Homo sapiens_hsa042100.57920916
107HTLV-I infection_Homo sapiens_hsa051660.57293166
108Chronic myeloid leukemia_Homo sapiens_hsa052200.55966504
109Leishmaniasis_Homo sapiens_hsa051400.55192929
110Osteoclast differentiation_Homo sapiens_hsa043800.54867046
111Prostate cancer_Homo sapiens_hsa052150.53030361
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.52846408
113Insulin signaling pathway_Homo sapiens_hsa049100.52722971
114Renal cell carcinoma_Homo sapiens_hsa052110.52235805
115Estrogen signaling pathway_Homo sapiens_hsa049150.48938601
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.47072756
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45341315
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45291226
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44625681
120Prolactin signaling pathway_Homo sapiens_hsa049170.44174020
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.42625925
122Shigellosis_Homo sapiens_hsa051310.42542954
123Glucagon signaling pathway_Homo sapiens_hsa049220.42489899
124Endocytosis_Homo sapiens_hsa041440.42444957
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39451742
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.39086551
127Fatty acid biosynthesis_Homo sapiens_hsa000610.36852196
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.31255165
129Glutamatergic synapse_Homo sapiens_hsa047240.29904330
130Protein export_Homo sapiens_hsa030600.27106035
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.25398296

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