DSG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.94547977
2cell wall macromolecule metabolic process (GO:0044036)9.94547977
3keratinization (GO:0031424)9.93082375
4adhesion of symbiont to host (GO:0044406)8.69076195
5peptide cross-linking (GO:0018149)8.05407245
6synapsis (GO:0007129)7.52696637
7hair follicle morphogenesis (GO:0031069)6.96561606
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.96555586
9establishment of skin barrier (GO:0061436)6.57158900
10intermediate filament cytoskeleton organization (GO:0045104)6.16249971
11citrulline biosynthetic process (GO:0019240)6.07048183
12intermediate filament-based process (GO:0045103)5.94424434
13regulation of water loss via skin (GO:0033561)5.78367191
14fatty acid elongation (GO:0030497)5.68579795
15DNA synthesis involved in DNA repair (GO:0000731)5.58033825
16* epidermis development (GO:0008544)5.54267385
17* hair cycle process (GO:0022405)5.33332045
18* molting cycle process (GO:0022404)5.33332045
19* keratinocyte differentiation (GO:0030216)5.31040422
20male meiosis I (GO:0007141)5.24534333
21cell-substrate junction assembly (GO:0007044)5.19186104
22chromosome organization involved in meiosis (GO:0070192)5.02125063
23male meiosis (GO:0007140)4.95565024
24hemidesmosome assembly (GO:0031581)4.90849977
25piRNA metabolic process (GO:0034587)4.77029071
26epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.53190675
27bone trabecula formation (GO:0060346)4.49903266
28DNA methylation involved in gamete generation (GO:0043046)4.48100123
29tooth mineralization (GO:0034505)4.35677922
30* epidermal cell differentiation (GO:0009913)4.33962521
31synaptonemal complex assembly (GO:0007130)4.20976890
32positive regulation of hair follicle development (GO:0051798)4.20875991
33positive regulation of hair cycle (GO:0042635)4.20875991
34meiosis I (GO:0007127)4.15856176
35gap junction assembly (GO:0016264)4.10985050
36regulation of hair follicle development (GO:0051797)4.10000318
37citrulline metabolic process (GO:0000052)4.03842851
38multicellular organismal water homeostasis (GO:0050891)4.02982614
39negative regulation of inclusion body assembly (GO:0090084)4.01485348
40synaptonemal complex organization (GO:0070193)4.00016566
41* hair follicle development (GO:0001942)3.99870936
42keratinocyte development (GO:0003334)3.98308619
43cranial suture morphogenesis (GO:0060363)3.94587464
44skin morphogenesis (GO:0043589)3.89127549
45genitalia morphogenesis (GO:0035112)3.88065819
46negative regulation of keratinocyte proliferation (GO:0010839)3.87823580
47cell surface receptor signaling pathway involved in heart development (GO:0061311)3.87099387
48positive regulation of epidermal cell differentiation (GO:0045606)3.84128520
49regulation of hair cycle (GO:0042634)3.78288173
50positive regulation of meiotic cell cycle (GO:0051446)3.66825223
51negative regulation of chondrocyte differentiation (GO:0032331)3.65102317
52ectoderm development (GO:0007398)3.62305481
53meiotic nuclear division (GO:0007126)3.61400952
54retinal cone cell development (GO:0046549)3.57936587
55negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.39056534
56very long-chain fatty acid metabolic process (GO:0000038)3.38284882
57peptidyl-arginine modification (GO:0018195)3.29588284
58chemical homeostasis within a tissue (GO:0048875)3.28706266
59lateral sprouting from an epithelium (GO:0060601)3.27075283
60surfactant homeostasis (GO:0043129)3.25304804
61water homeostasis (GO:0030104)3.23676987
62lymphangiogenesis (GO:0001946)3.20593201
63mesodermal cell differentiation (GO:0048333)3.19001248
64negative regulation of neurotransmitter secretion (GO:0046929)3.17321475
65polarized epithelial cell differentiation (GO:0030859)3.16693772
66sodium ion export (GO:0071436)3.15857384
67cellular zinc ion homeostasis (GO:0006882)3.13176832
68snRNA transcription (GO:0009301)3.12376474
69wound healing, spreading of epidermal cells (GO:0035313)3.11392523
70long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.10581221
71regulation of mesenchymal cell apoptotic process (GO:2001053)3.04178002
72molting cycle (GO:0042303)23.1488813
73hair cycle (GO:0042633)23.1488813
74regulation of keratinocyte differentiation (GO:0045616)2.98651159
75renal system development (GO:0072001)2.96035484
76keratinocyte proliferation (GO:0043616)2.95419146
77fusion of sperm to egg plasma membrane (GO:0007342)2.94653512
78regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.92112698
79chondrocyte development (GO:0002063)2.90325498
80embryonic retina morphogenesis in camera-type eye (GO:0060059)2.89437715
81linoleic acid metabolic process (GO:0043651)2.89101804
82regulation of inclusion body assembly (GO:0090083)2.88246419
83reciprocal DNA recombination (GO:0035825)2.86668508
84reciprocal meiotic recombination (GO:0007131)2.86668508
85ventricular cardiac muscle cell action potential (GO:0086005)2.84104906
86fatty-acyl-CoA biosynthetic process (GO:0046949)2.84072292
87* epithelium development (GO:0060429)2.83509468
88artery development (GO:0060840)2.81959515
89long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.79559872
90negative regulation of epidermis development (GO:0045683)2.79376364
91planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78382391
92positive regulation of epidermis development (GO:0045684)2.78235371
93atrioventricular valve morphogenesis (GO:0003181)2.77010779
94negative regulation of cell fate specification (GO:0009996)2.76501499
95respiratory tube development (GO:0030323)2.76114089
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.68693998
97regulation of protein polyubiquitination (GO:1902914)2.67571884
98tongue development (GO:0043586)2.66073036
99regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.64060427
100G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.63462773
101negative regulation of protein localization to plasma membrane (GO:1903077)2.62280649
102outflow tract septum morphogenesis (GO:0003148)2.61934823
103negative regulation of cartilage development (GO:0061037)2.59842101
104regulation of cell fate specification (GO:0042659)2.58008347
105positive regulation of meiosis (GO:0045836)2.55568185
106craniofacial suture morphogenesis (GO:0097094)2.55454521
107inner ear receptor cell differentiation (GO:0060113)2.55187055
108dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52487818
109mesenchymal cell differentiation involved in kidney development (GO:0072161)2.51129173
110mesenchymal cell differentiation involved in renal system development (GO:2001012)2.51129173
111anatomical structure regression (GO:0060033)2.50282270
112cell adhesion mediated by integrin (GO:0033627)2.50235126
113branching involved in mammary gland duct morphogenesis (GO:0060444)2.50182755
114regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.48926388
115regulation of heart rate by cardiac conduction (GO:0086091)2.48735234
116regulation of epidermal cell differentiation (GO:0045604)2.48714057
117non-canonical Wnt signaling pathway (GO:0035567)2.47815476
118cell communication involved in cardiac conduction (GO:0086065)2.47473560
119negative regulation of complement activation (GO:0045916)2.46151415
120photoreceptor cell maintenance (GO:0045494)2.45678994
121retinol metabolic process (GO:0042572)2.45578977
122skin development (GO:0043588)2.45308364
123coenzyme catabolic process (GO:0009109)2.44813146
124establishment of planar polarity (GO:0001736)2.44690453
125establishment of tissue polarity (GO:0007164)2.44690453
126acyl-CoA biosynthetic process (GO:0071616)2.44049820
127thioester biosynthetic process (GO:0035384)2.44049820
128zinc ion homeostasis (GO:0055069)2.43908876
129cardiac epithelial to mesenchymal transition (GO:0060317)2.43077881
130negative regulation of catenin import into nucleus (GO:0035414)2.41885763
131intestinal epithelial cell development (GO:0060576)2.40438189
132regulation of keratinocyte proliferation (GO:0010837)2.40339677
133positive regulation of keratinocyte differentiation (GO:0045618)2.39254198
134sphingoid metabolic process (GO:0046519)2.38722282
135dendritic spine morphogenesis (GO:0060997)2.37470837
136odontogenesis of dentin-containing tooth (GO:0042475)2.35574595
137glomerular visceral epithelial cell development (GO:0072015)2.34584619
138Sertoli cell development (GO:0060009)2.34515031
139gland morphogenesis (GO:0022612)2.31767967
140regulation of epidermis development (GO:0045682)2.31196527
141regulation of cardioblast differentiation (GO:0051890)2.29944996
142muscle organ morphogenesis (GO:0048644)2.28754908
143asymmetric protein localization (GO:0008105)2.28452511
144auditory receptor cell differentiation (GO:0042491)2.26389813
145epithelial cell differentiation involved in prostate gland development (GO:0060742)2.25605274
146regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.22713552
147copper ion transport (GO:0006825)2.20087734
148dorsal/ventral axis specification (GO:0009950)2.19508038
149neural crest cell development (GO:0014032)2.19269654
150eyelid development in camera-type eye (GO:0061029)2.18676341
151positive regulation of monocyte chemotaxis (GO:0090026)2.17770023
152negative regulation of neurotransmitter transport (GO:0051589)2.15876498
153desmosome organization (GO:0002934)12.1339405
154intermediate filament organization (GO:0045109)10.6402074
155adhesion of symbiont to host cell (GO:0044650)10.3965264
156virion attachment to host cell (GO:0019062)10.3965264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.30706645
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.16157578
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.27008948
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52399721
5* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.52389655
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.08531153
7TP63_17297297_ChIP-ChIP_HaCaT_Human10.7814887
8AR_21572438_ChIP-Seq_LNCaP_Human1.91459536
9SOX9_24532713_ChIP-Seq_HFSC_Mouse1.90675482
10AHR_22903824_ChIP-Seq_MCF-7_Human1.78742154
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74384664
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74333771
13BCAT_22108803_ChIP-Seq_LS180_Human1.74002314
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69770148
15TP53_18474530_ChIP-ChIP_U2OS_Human1.68813957
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68167972
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.67820280
18ARNT_22903824_ChIP-Seq_MCF-7_Human1.66520995
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53158826
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.52529514
21TP63_23658742_ChIP-Seq_EP156T_Human1.46934767
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45432620
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44468129
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41560586
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41182666
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.39159684
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.37996474
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33069975
29MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.30612467
30* PIAS1_25552417_ChIP-Seq_VCAP_Human1.30510934
31RXR_22108803_ChIP-Seq_LS180_Human1.26850082
32* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26804280
33* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26804280
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.25290928
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23572953
36BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22222429
37IGF1R_20145208_ChIP-Seq_DFB_Human1.20321432
38GATA3_24758297_ChIP-Seq_MCF-7_Human1.19517247
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.19387641
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18796470
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.17657845
42NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.16222289
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16182042
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15286981
45ZNF263_19887448_ChIP-Seq_K562_Human1.14049338
46EGR1_19032775_ChIP-ChIP_M12_Human1.13072014
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12243530
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10657025
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.07561397
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05178237
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05178237
52KLF5_25053715_ChIP-Seq_YYC3_Human1.05177603
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.05109880
54CJUN_26792858_Chip-Seq_BT549_Human1.02973955
55ERG_20517297_ChIP-Seq_VCAP_Human1.02772195
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.02154450
57GATA4_25053715_ChIP-Seq_YYC3_Human1.01271186
58EED_16625203_ChIP-ChIP_MESCs_Mouse0.98981697
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98534472
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97560411
61SALL1_21062744_ChIP-ChIP_HESCs_Human0.97501415
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97273140
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97032859
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95919974
65RING1B_27294783_Chip-Seq_NPCs_Mouse0.95805874
66RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95685230
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95388158
68SOX2_20726797_ChIP-Seq_SW620_Human0.94687791
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94518227
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94491949
71RUNX1_27514584_Chip-Seq_MCF-7_Human0.93737410
72TAF2_19829295_ChIP-Seq_ESCs_Human0.92967969
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92862261
74JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92202297
75MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91071887
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90713069
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90498425
78TP63_22573176_ChIP-Seq_HFKS_Human0.90306686
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89986005
80UBF1/2_26484160_Chip-Seq_HMECs_Human0.89875347
81P53_21459846_ChIP-Seq_SAOS-2_Human0.89513731
82PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88758303
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88699526
84CBX2_27304074_Chip-Seq_ESCs_Mouse0.88669049
85RUNX_20019798_ChIP-Seq_JUKART_Human0.87031295
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86967482
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86645917
88* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86614289
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85734435
90E2F1_20622854_ChIP-Seq_HELA_Human0.84885661
91CEBPB_22108803_ChIP-Seq_LS180_Human0.84858848
92WDR5_24793694_ChIP-Seq_LNCAP_Human0.84368170
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.84267860
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.84059144
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83970267
96CDX2_22108803_ChIP-Seq_LS180_Human0.83752938
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83673934
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83537900
99ATF3_27146783_Chip-Seq_COLON_Human0.83463804
100AR_25329375_ChIP-Seq_VCAP_Human0.83212941
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82896153
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.81662021
103CTCF_20526341_ChIP-Seq_ESCs_Human0.81486784
104* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81143559
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80988797
106NANOG_20526341_ChIP-Seq_ESCs_Human0.80980547
107STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80969691
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80884099
109CTCF_27219007_Chip-Seq_Bcells_Human0.80021818
110SMAD3_21741376_ChIP-Seq_EPCs_Human0.79870073
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79674230
112ERG_21242973_ChIP-ChIP_JURKAT_Human0.79267415
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79265428
114TCF4_22108803_ChIP-Seq_LS180_Human0.79253620
115CSB_26484114_Chip-Seq_FIBROBLAST_Human0.77500888
116SMAD4_21799915_ChIP-Seq_A2780_Human0.76998523
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.76956999
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.76579919
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.76526597
120P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.75742560
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74757584
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.73488196
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72938590
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69643514
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.69434833
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.69332171
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69201242
128RBPJ_21746931_ChIP-Seq_IB4_Human0.68645475
129CBX2_22325352_ChIP-Seq_293T-Rex_Human0.68444782
130ETV1_20927104_ChIP-Seq_GIST48_Human0.67689199
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67579550
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.66066472
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.66066472
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.65506140
135* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.64082013
136* FOXA1_25329375_ChIP-Seq_VCAP_Human0.64082013
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63816677
138BCOR_27268052_Chip-Seq_Bcells_Human0.62931316
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.61271470
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.61029168
141GATA2_21666600_ChIP-Seq_HMVEC_Human0.60074242
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.59778391
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.58824466
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58518136
145CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.58101006
146PHF8_20622853_ChIP-Seq_HELA_Human0.57993410
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.57110221
148TCF4_23295773_ChIP-Seq_U87_Human0.56993367
149KLF5_20875108_ChIP-Seq_MESCs_Mouse0.56897543
150STAT3_23295773_ChIP-Seq_U87_Human0.56830337
151NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56765395
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56765395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000579_abnormal_nail_morphology7.22932203
2* MP0002098_abnormal_vibrissa_morphology6.08651331
3MP0002796_impaired_skin_barrier5.87746096
4* MP0000647_abnormal_sebaceous_gland5.21643453
5* MP0000383_abnormal_hair_follicle4.89784221
6MP0002254_reproductive_system_inflammat4.51734973
7* MP0010678_abnormal_skin_adnexa4.26113663
8* MP0000377_abnormal_hair_follicle4.08328591
9MP0010234_abnormal_vibrissa_follicle3.96553115
10* MP0000427_abnormal_hair_cycle3.64007970
11MP0005501_abnormal_skin_physiology3.36508070
12* MP0005275_abnormal_skin_tensile3.04990094
13MP0004381_abnormal_hair_follicle2.91417723
14MP0005409_darkened_coat_color2.76555593
15MP0003705_abnormal_hypodermis_morpholog2.73732850
16* MP0001216_abnormal_epidermal_layer2.64992543
17MP0003453_abnormal_keratinocyte_physiol2.30799336
18MP0003941_abnormal_skin_development2.29992736
19MP0001346_abnormal_lacrimal_gland2.26708352
20MP0002060_abnormal_skin_morphology2.21461234
21* MP0010771_integument_phenotype2.19094800
22* MP0000367_abnormal_coat/_hair2.11834294
23MP0000566_synostosis2.05845891
24MP0005451_abnormal_body_composition2.03391742
25* MP0004947_skin_inflammation1.96309805
26MP0000762_abnormal_tongue_morphology1.80828523
27MP0000467_abnormal_esophagus_morphology1.74660254
28MP0002009_preneoplasia1.72195372
29MP0003566_abnormal_cell_adhesion1.65446970
30* MP0001243_abnormal_dermal_layer1.60201362
31MP0008260_abnormal_autophagy1.53139236
32MP0009379_abnormal_foot_pigmentation1.43319696
33MP0001188_hyperpigmentation1.37946266
34MP0002234_abnormal_pharynx_morphology1.35932363
35MP0004264_abnormal_extraembryonic_tissu1.33445971
36* MP0009931_abnormal_skin_appearance1.28311949
37MP0003136_yellow_coat_color1.22088972
38* MP0002095_abnormal_skin_pigmentation1.13768862
39MP0004885_abnormal_endolymph1.13537671
40MP0001340_abnormal_eyelid_morphology1.11042835
41MP0008877_abnormal_DNA_methylation1.10830402
42MP0010030_abnormal_orbit_morphology1.10821675
43MP0004019_abnormal_vitamin_homeostasis1.08989191
44MP0009384_cardiac_valve_regurgitation1.04279412
45MP0005171_absent_coat_pigmentation1.04028122
46MP0005360_urolithiasis1.03564814
47MP0009053_abnormal_anal_canal1.02747823
48MP0000678_abnormal_parathyroid_gland1.00873210
49MP0003315_abnormal_perineum_morphology0.87946122
50MP0003329_amyloid_beta_deposits0.87119454
51MP0001851_eye_inflammation0.86369926
52MP0002210_abnormal_sex_determination0.82742683
53MP0002166_altered_tumor_susceptibility0.81199462
54MP0000372_irregular_coat_pigmentation0.81134623
55MP0002282_abnormal_trachea_morphology0.81070264
56MP0002006_tumorigenesis0.80341457
57MP0004782_abnormal_surfactant_physiolog0.79076718
58MP0008438_abnormal_cutaneous_collagen0.78799728
59MP0002177_abnormal_outer_ear0.77541984
60MP0002160_abnormal_reproductive_system0.76369078
61* MP0001191_abnormal_skin_condition0.76219472
62MP0003011_delayed_dark_adaptation0.74922415
63MP0003755_abnormal_palate_morphology0.74283747
64MP0004185_abnormal_adipocyte_glucose0.73336519
65MP0005410_abnormal_fertilization0.72984099
66MP0005248_abnormal_Harderian_gland0.72472082
67MP0000627_abnormal_mammary_gland0.71848192
68MP0004043_abnormal_pH_regulation0.70466587
69MP0005408_hypopigmentation0.68590757
70MP0002697_abnormal_eye_size0.68131025
71MP0002938_white_spotting0.68014999
72MP0003698_abnormal_male_reproductive0.67147751
73MP0000432_abnormal_head_morphology0.66749295
74MP0000465_gastrointestinal_hemorrhage0.66541932
75MP0002638_abnormal_pupillary_reflex0.66255526
76MP0005310_abnormal_salivary_gland0.65830886
77MP0000569_abnormal_digit_pigmentation0.65300127
78MP0005075_abnormal_melanosome_morpholog0.64198070
79MP0010386_abnormal_urinary_bladder0.64101444
80MP0001929_abnormal_gametogenesis0.63233604
81MP0003890_abnormal_embryonic-extraembry0.63134184
82MP0005389_reproductive_system_phenotype0.60334565
83MP0005377_hearing/vestibular/ear_phenot0.58723892
84MP0003878_abnormal_ear_physiology0.58723892
85MP0001286_abnormal_eye_development0.58720308
86MP0000516_abnormal_urinary_system0.55173310
87MP0005367_renal/urinary_system_phenotyp0.55173310
88MP0004272_abnormal_basement_membrane0.52309769
89MP0002877_abnormal_melanocyte_morpholog0.51937509
90MP0001145_abnormal_male_reproductive0.51266562
91MP0003385_abnormal_body_wall0.51171414
92MP0005023_abnormal_wound_healing0.48323998
93MP0005257_abnormal_intraocular_pressure0.47977070
94MP0005197_abnormal_uvea_morphology0.47597848
95MP0000015_abnormal_ear_pigmentation0.45700816
96MP0010368_abnormal_lymphatic_system0.45163088
97* MP0001784_abnormal_fluid_regulation0.45155912
98MP0001849_ear_inflammation0.44998039
99MP0000653_abnormal_sex_gland0.44971130
100MP0000613_abnormal_salivary_gland0.44946465
101MP0001186_pigmentation_phenotype0.42942830
102MP0002111_abnormal_tail_morphology0.42044215
103MP0004742_abnormal_vestibular_system0.41558397
104MP0001299_abnormal_eye_distance/0.41024402
105MP0003045_fibrosis0.40569808
106MP0001765_abnormal_ion_homeostasis0.40185651
107MP0003935_abnormal_craniofacial_develop0.39533925
108MP0003937_abnormal_limbs/digits/tail_de0.37305223
109MP0003638_abnormal_response/metabolism_0.36639384
110MP0002075_abnormal_coat/hair_pigmentati0.36549503
111MP0003191_abnormal_cellular_cholesterol0.36445115
112MP0001879_abnormal_lymphatic_vessel0.35682437
113MP0005076_abnormal_cell_differentiation0.35308727
114MP0001293_anophthalmia0.34643365
115MP0003718_maternal_effect0.34094154
116MP0003300_gastrointestinal_ulcer0.33443491
117MP0001986_abnormal_taste_sensitivity0.33385228
118MP0003786_premature_aging0.33202752
119MP0003950_abnormal_plasma_membrane0.32989297
120MP0002249_abnormal_larynx_morphology0.32495904
121MP0005193_abnormal_anterior_eye0.31398657
122MP0005423_abnormal_somatic_nervous0.30708578
123MP0000462_abnormal_digestive_system0.30336583
124MP0002233_abnormal_nose_morphology0.29472509
125MP0002090_abnormal_vision0.29322000
126MP0000371_diluted_coat_color0.28986003
127MP0005551_abnormal_eye_electrophysiolog0.27966458
128MP0000428_abnormal_craniofacial_morphol0.27939975
129MP0000538_abnormal_urinary_bladder0.27172028
130MP0001119_abnormal_female_reproductive0.25383758
131MP0003699_abnormal_female_reproductive0.25045434
132MP0000470_abnormal_stomach_morphology0.24303120
133MP0003936_abnormal_reproductive_system0.22978646
134MP0002109_abnormal_limb_morphology0.22795706
135MP0004510_myositis0.22726976
136MP0000537_abnormal_urethra_morphology0.22722606
137MP0002896_abnormal_bone_mineralization0.20415612
138MP0005174_abnormal_tail_pigmentation0.19415403
139MP0002092_abnormal_eye_morphology0.18147119
140MP0010352_gastrointestinal_tract_polyps0.17917525
141MP0005508_abnormal_skeleton_morphology0.17207436
142MP0002133_abnormal_respiratory_system0.15361383

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of hair growth rate (HP:0011363)6.95357107
2* Slow-growing hair (HP:0002217)6.95357107
3Abnormality of nail color (HP:0100643)6.90871504
4* Pili torti (HP:0003777)6.45798688
5Fragile nails (HP:0001808)6.24318044
6Nail dystrophy (HP:0008404)5.59109509
7Alopecia of scalp (HP:0002293)5.46094382
8Palmoplantar hyperkeratosis (HP:0000972)5.28823834
9Palmar hyperkeratosis (HP:0010765)5.12881665
10Right ventricular cardiomyopathy (HP:0011663)5.03477984
11* Brittle hair (HP:0002299)4.97692802
12Plantar hyperkeratosis (HP:0007556)4.89594128
13Parakeratosis (HP:0001036)4.36962407
14Onycholysis (HP:0001806)4.33857841
15Abnormality of the frontal sinuses (HP:0002687)4.24126560
16Amelogenesis imperfecta (HP:0000705)4.16477621
17* Abnormal hair laboratory examination (HP:0003328)3.99308037
18Thick nail (HP:0001805)3.85164752
19Aplasia cutis congenita (HP:0001057)3.80777770
20Increased IgE level (HP:0003212)3.77847472
21Milia (HP:0001056)3.60882088
22* Fine hair (HP:0002213)3.52177756
23* Sparse eyelashes (HP:0000653)3.47723125
24Oral leukoplakia (HP:0002745)3.46643170
25Abnormality of the parietal bone (HP:0002696)3.34891029
26Natal tooth (HP:0000695)3.30989056
27Advanced eruption of teeth (HP:0006288)3.21996311
28Lip pit (HP:0100267)3.18965689
29Absent eyelashes (HP:0000561)3.17167571
30Erythroderma (HP:0001019)3.11645116
31Curly hair (HP:0002212)3.09953358
32Hypoplasia of dental enamel (HP:0006297)2.99925236
33Absent eyebrow (HP:0002223)2.75602484
34Abnormality of molar (HP:0011077)2.71877950
35Abnormality of molar morphology (HP:0011070)2.71877950
36Taurodontia (HP:0000679)2.70846522
37Abnormality of permanent molar morphology (HP:0011071)2.70846522
38Abnormality of the dental root (HP:0006486)2.70846522
39Intention tremor (HP:0002080)2.67824743
40Congenital ichthyosiform erythroderma (HP:0007431)2.56822324
41Concave nail (HP:0001598)2.49415982
42Dry hair (HP:0011359)2.47251904
43Hypoplastic labia majora (HP:0000059)2.46174331
44Abnormality of the dental pulp (HP:0006479)2.43189556
45Ridged nail (HP:0001807)2.42173742
46Rectal prolapse (HP:0002035)2.41148040
47Abnormal blistering of the skin (HP:0008066)2.36562272
48Widely patent fontanelles and sutures (HP:0004492)2.34765505
49Hypodontia (HP:0000668)2.32216886
50Widely spaced teeth (HP:0000687)2.31972527
51Keratoconjunctivitis (HP:0001096)2.28623441
52Craniofacial hyperostosis (HP:0004493)2.27431686
53Ventricular fibrillation (HP:0001663)2.26949545
54Corneal erosion (HP:0200020)2.26805459
55Ventricular tachycardia (HP:0004756)2.22328782
56Fragile skin (HP:0001030)2.20986077
57Blepharitis (HP:0000498)2.20792349
58* Erythema (HP:0010783)2.19713905
59Abnormality of the labia majora (HP:0012881)2.17348050
60Torticollis (HP:0000473)2.17041497
61Recurrent corneal erosions (HP:0000495)2.16643355
62Amniotic constriction ring (HP:0009775)2.16047134
63Abnormality of placental membranes (HP:0011409)2.16047134
64Hypohidrosis (HP:0000966)2.15241782
65Keratoconjunctivitis sicca (HP:0001097)2.15112731
66* Follicular hyperkeratosis (HP:0007502)2.14377599
67Abnormality of the nasal septum (HP:0000419)2.13475829
68Abnormality of dental color (HP:0011073)2.11600780
69Pterygium (HP:0001059)2.11411832
70Neck muscle weakness (HP:0000467)2.07398420
71Hypotrichosis (HP:0001006)11.5033284
72* Woolly hair (HP:0002224)10.7955359
73Palmoplantar keratoderma (HP:0000982)1.99993488
74Shoulder girdle muscle weakness (HP:0003547)1.96239193
75Abnormality of the axillary hair (HP:0100134)1.95024008
76Abnormality of secondary sexual hair (HP:0009888)1.95024008
77Oligodontia (HP:0000677)1.92604345
78Sparse scalp hair (HP:0002209)1.91346448
79Hyperhidrosis (HP:0000975)1.90601727
80Laryngomalacia (HP:0001601)1.88244621
81Coarse hair (HP:0002208)1.85487206
82Oligodactyly (hands) (HP:0001180)1.84542191
83Hoarse voice (HP:0001609)1.84041393
84Split foot (HP:0001839)1.83559711
85Abnormality of the right ventricle (HP:0001707)1.83387231
86Abnormality of the gastric mucosa (HP:0004295)1.82900695
87Absent hair (HP:0002298)1.81252604
88Carious teeth (HP:0000670)1.80938241
89Hematochezia (HP:0002573)1.80410235
90Abnormality of the salivary glands (HP:0010286)1.77867823
91Esophageal atresia (HP:0002032)1.74370939
92Craniofacial dystonia (HP:0012179)1.71428384
93Septate vagina (HP:0001153)1.70679835
94Cranial hyperostosis (HP:0004437)1.70376380
95Deviation of the thumb (HP:0009603)1.68909339
96Dehydration (HP:0001944)1.68189590
97Atrophic scars (HP:0001075)1.67621246
98Fair hair (HP:0002286)1.67494529
99* Pruritus (HP:0000989)1.66406408
100Difficulty walking (HP:0002355)1.65188100
101Selective tooth agenesis (HP:0001592)1.63701308
102Proximal placement of thumb (HP:0009623)1.63069420
103Gangrene (HP:0100758)1.62782481
104Neonatal death (HP:0003811)1.62665104
105Abnormality of the neuromuscular junction (HP:0003398)1.61641453
106Fatigable weakness (HP:0003473)1.61641453
107Acanthosis nigricans (HP:0000956)1.61222373
108Abnormality of the fingernails (HP:0001231)1.57889451
109Skin ulcer (HP:0200042)1.57280512
110Abnormality of the pupil (HP:0000615)1.57250962
111Premature loss of primary teeth (HP:0006323)1.55670037
112Hyporeflexia of lower limbs (HP:0002600)1.55528816
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.54982555
114Focal dystonia (HP:0004373)1.54631002
115Abnormality of the lower motor neuron (HP:0002366)1.54053865
116Anonychia (HP:0001798)1.50211667
117Neurofibrillary tangles (HP:0002185)1.47797727
118Adrenal hypoplasia (HP:0000835)1.46433226
119Microglossia (HP:0000171)1.46321002
120Autoamputation (HP:0001218)1.43850945
121Corneal dystrophy (HP:0001131)1.43032131
122Unilateral renal agenesis (HP:0000122)1.42548205
123Short 4th metacarpal (HP:0010044)1.40738347
124Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.40738347
125Popliteal pterygium (HP:0009756)1.40007350
126Labial hypoplasia (HP:0000066)1.38849898
127Anhidrosis (HP:0000970)1.38776280
128Deep philtrum (HP:0002002)1.38054675
129Duplicated collecting system (HP:0000081)1.37339916
130Ectropion (HP:0000656)1.36615968
131Delayed CNS myelination (HP:0002188)1.35707813
132Ankyloglossia (HP:0010296)1.29774044
133Hypoplastic female external genitalia (HP:0012815)1.28622598
134Blue irides (HP:0000635)1.27987412
135Upper motor neuron abnormality (HP:0002127)1.27591321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK26.90566219
2FGFR25.23205086
3LATS13.74300882
4ARAF3.59380286
5STK38L3.50326207
6AKT33.07341972
7FER3.07030477
8FGFR33.04521450
9FGFR13.04161035
10MST43.00253993
11MAP3K22.87194228
12BCR2.85517377
13EPHA22.80102207
14MST1R2.80075374
15FRK2.59774587
16LMTK22.53105953
17EPHA32.43555244
18EPHB22.32841113
19PIM22.15618362
20TGFBR12.15428189
21EPHB12.08239171
22STK381.94597950
23CSF1R1.91438130
24NEK61.83709913
25CDK61.61501069
26OXSR11.48506302
27ERN11.47687350
28BMX1.44670222
29MAP3K61.42577397
30MAP3K31.37497799
31BLK1.33593905
32JAK31.32699757
33ERBB41.30467993
34CSNK1G11.29124246
35NLK1.24585966
36RPS6KB21.23246100
37PTK61.22135064
38PDGFRA1.21276817
39TYRO31.19830261
40PHKG11.18492590
41PHKG21.18492590
42GRK11.14256242
43STK31.13615679
44TAOK11.12906969
45DYRK1B1.10491067
46MAP3K91.09009567
47PBK1.08374391
48STK101.06943026
49FGFR41.05663533
50MET1.03635498
51PTK2B1.01643813
52RIPK10.98647514
53SCYL20.97274442
54NTRK10.93797889
55TTN0.93351315
56FGR0.93049460
57MAPKAPK30.90810286
58CDK120.88948332
59PAK30.87577282
60ERBB20.86405141
61KSR20.85917672
62MAPK70.85819768
63RET0.85228762
64TRPM70.83209841
65MAPKAPK20.81307399
66JAK10.81065808
67PIK3CG0.80513153
68CSNK1A1L0.78637553
69MAP3K70.77585970
70LRRK20.74103803
71ITK0.73334157
72MAPKAPK50.72884252
73MAPK120.72299942
74ERBB30.71959568
75PKN10.70980282
76NME10.70745335
77PTK20.70358779
78GSK3A0.70155400
79CAMK1G0.69773211
80MAP2K60.69753020
81ROCK10.69143642
82LATS20.68582985
83RPS6KB10.68489538
84MAP3K130.65255366
85PDK10.61347013
86WNK40.60394858
87CSNK1E0.60371275
88BMPR1B0.58104038
89CDC42BPA0.57663228
90SGK20.57621280
91PRKCH0.57415202
92MTOR0.55648766
93PDPK10.55006097
94PLK40.52839058
95EEF2K0.52282797
96DDR20.52112623
97SIK10.51351271
98DAPK20.50316393
99ADRBK10.49927474
100PNCK0.49762427
101SGK30.49640323
102STK390.49015821
103STK240.48499049
104MAP2K20.48477039
105PRKCE0.48171853
106BRAF0.47710500
107ROCK20.47290049
108EGFR0.46400916
109NUAK10.45572554
110MAP3K100.45386708
111RPS6KA10.44180412
112PDGFRB0.44125109
113MOS0.43733692
114AURKB0.43598061
115SGK10.43360639
116NTRK20.43048235
117FYN0.41590879
118CLK10.41447762
119CSNK1G30.41405589
120NME20.40167602
121MAP2K40.40153001
122PRKCI0.39178543
123ACVR1B0.37369790
124SGK2230.36006725
125SGK4940.36006725
126MKNK20.35751494
127PRKACG0.35275678
128IGF1R0.33544683
129DMPK0.33295010
130PAK20.33273091
131EIF2AK20.33094600
132ZAK0.32496929
133IRAK20.31483787
134PRKACA0.30791444
135MAP3K10.29545347
136RAF10.28555376
137SRC0.28174553
138WNK10.27702633
139MARK20.27691757
140INSR0.27368325
141CAMK1D0.25806087
142CSNK1D0.25202588
143PRKAA20.22830291
144NEK90.22371573
145PKN20.20452766
146CDK190.18707783
147CCNB10.17517719
148ABL10.17225288
149IKBKB0.16208073
150PRKAA10.14797445
151CSNK1A10.12735587
152PRKD10.12265559
153PRKCQ0.10436203
154RPS6KA20.10339031

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.61755170
2Fatty acid biosynthesis_Homo sapiens_hsa000613.09471015
3Glycerolipid metabolism_Homo sapiens_hsa005612.74662044
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46090835
5Linoleic acid metabolism_Homo sapiens_hsa005912.43615108
6Hedgehog signaling pathway_Homo sapiens_hsa043402.40556484
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28907421
8Hippo signaling pathway_Homo sapiens_hsa043902.26129313
9ABC transporters_Homo sapiens_hsa020102.21023108
10Mineral absorption_Homo sapiens_hsa049782.13874192
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.12877858
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.06460851
13Melanogenesis_Homo sapiens_hsa049162.05816524
14Histidine metabolism_Homo sapiens_hsa003402.00956785
15Dorso-ventral axis formation_Homo sapiens_hsa043202.00325415
16Fatty acid elongation_Homo sapiens_hsa000621.94036314
17Phenylalanine metabolism_Homo sapiens_hsa003601.88022890
18Sphingolipid metabolism_Homo sapiens_hsa006001.86248734
19Ether lipid metabolism_Homo sapiens_hsa005651.82802510
20Adherens junction_Homo sapiens_hsa045201.81907001
21Axon guidance_Homo sapiens_hsa043601.74225874
22Fatty acid metabolism_Homo sapiens_hsa012121.62106057
23TGF-beta signaling pathway_Homo sapiens_hsa043501.60731429
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60286727
25Tyrosine metabolism_Homo sapiens_hsa003501.59452899
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.55456587
27Proteoglycans in cancer_Homo sapiens_hsa052051.55427447
28Bladder cancer_Homo sapiens_hsa052191.54597543
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49562077
30Wnt signaling pathway_Homo sapiens_hsa043101.49547308
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43952994
32PPAR signaling pathway_Homo sapiens_hsa033201.41771634
33Fatty acid degradation_Homo sapiens_hsa000711.39059204
34Nitrogen metabolism_Homo sapiens_hsa009101.37537499
35Lysine degradation_Homo sapiens_hsa003101.35796295
36Notch signaling pathway_Homo sapiens_hsa043301.35444757
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31001872
38Tight junction_Homo sapiens_hsa045301.30231756
39Steroid biosynthesis_Homo sapiens_hsa001001.28195683
40Fat digestion and absorption_Homo sapiens_hsa049751.26210559
41MicroRNAs in cancer_Homo sapiens_hsa052061.23924130
42ECM-receptor interaction_Homo sapiens_hsa045121.22813751
43Long-term potentiation_Homo sapiens_hsa047201.21764725
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20740899
45Butanoate metabolism_Homo sapiens_hsa006501.17439088
46Glioma_Homo sapiens_hsa052141.16204071
47Thyroid cancer_Homo sapiens_hsa052161.14725761
48Endometrial cancer_Homo sapiens_hsa052131.12093160
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.05372147
50Protein digestion and absorption_Homo sapiens_hsa049741.02467711
51Long-term depression_Homo sapiens_hsa047301.02253576
52Propanoate metabolism_Homo sapiens_hsa006400.98045582
53Bile secretion_Homo sapiens_hsa049760.96153192
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.95264452
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93526522
56beta-Alanine metabolism_Homo sapiens_hsa004100.93225671
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91464557
58Arachidonic acid metabolism_Homo sapiens_hsa005900.91216034
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.90167481
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86114616
61Focal adhesion_Homo sapiens_hsa045100.85823954
62Arginine and proline metabolism_Homo sapiens_hsa003300.83261281
63Olfactory transduction_Homo sapiens_hsa047400.82950296
64Pyruvate metabolism_Homo sapiens_hsa006200.82557773
65Melanoma_Homo sapiens_hsa052180.82546866
66Amoebiasis_Homo sapiens_hsa051460.80661046
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77889058
68Prostate cancer_Homo sapiens_hsa052150.77821354
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77608659
70p53 signaling pathway_Homo sapiens_hsa041150.77281570
71N-Glycan biosynthesis_Homo sapiens_hsa005100.76138752
72Inositol phosphate metabolism_Homo sapiens_hsa005620.75541293
73Rap1 signaling pathway_Homo sapiens_hsa040150.75488478
74Hepatitis C_Homo sapiens_hsa051600.74973133
75Gap junction_Homo sapiens_hsa045400.72114316
76Pathways in cancer_Homo sapiens_hsa052000.71488757
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70924515
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67435805
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66379615
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.65357374
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64299454
82GnRH signaling pathway_Homo sapiens_hsa049120.64066138
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63551326
84Tryptophan metabolism_Homo sapiens_hsa003800.63307991
85VEGF signaling pathway_Homo sapiens_hsa043700.63044321
86Pertussis_Homo sapiens_hsa051330.62680722
87Choline metabolism in cancer_Homo sapiens_hsa052310.62204473
88Non-small cell lung cancer_Homo sapiens_hsa052230.62112478
89Selenocompound metabolism_Homo sapiens_hsa004500.61675519
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61437296
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60783060
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60727234
93Renin secretion_Homo sapiens_hsa049240.59105652
94Arginine biosynthesis_Homo sapiens_hsa002200.59043067
95Ras signaling pathway_Homo sapiens_hsa040140.58112101
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.57695669
97Dilated cardiomyopathy_Homo sapiens_hsa054140.56776567
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56445576
99Gastric acid secretion_Homo sapiens_hsa049710.53779269
100One carbon pool by folate_Homo sapiens_hsa006700.52791676
101Insulin resistance_Homo sapiens_hsa049310.52528417
102Staphylococcus aureus infection_Homo sapiens_hsa051500.51187259
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51156948
104Salmonella infection_Homo sapiens_hsa051320.51154907
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50336166
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49766119
107Vitamin digestion and absorption_Homo sapiens_hsa049770.49644013
108Lysosome_Homo sapiens_hsa041420.49601471
109Renin-angiotensin system_Homo sapiens_hsa046140.49094230
110Serotonergic synapse_Homo sapiens_hsa047260.48378388
111Viral myocarditis_Homo sapiens_hsa054160.48197687
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48012604
113Pancreatic cancer_Homo sapiens_hsa052120.47552886
114Asthma_Homo sapiens_hsa053100.46712126
115Acute myeloid leukemia_Homo sapiens_hsa052210.44252748
116ErbB signaling pathway_Homo sapiens_hsa040120.43306378
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43085707
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.40977427
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40918369
120Small cell lung cancer_Homo sapiens_hsa052220.40621754
121Estrogen signaling pathway_Homo sapiens_hsa049150.39898452
122Renal cell carcinoma_Homo sapiens_hsa052110.39498833
123Caffeine metabolism_Homo sapiens_hsa002320.38934216
124cAMP signaling pathway_Homo sapiens_hsa040240.38214884
125Starch and sucrose metabolism_Homo sapiens_hsa005000.37376316
126Toxoplasmosis_Homo sapiens_hsa051450.36818325
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36012702
128Platelet activation_Homo sapiens_hsa046110.35735676
129Ovarian steroidogenesis_Homo sapiens_hsa049130.35037913
130Phototransduction_Homo sapiens_hsa047440.34311975
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33560006
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.33337546
133Retinol metabolism_Homo sapiens_hsa008300.33179271
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.33162160
135Oocyte meiosis_Homo sapiens_hsa041140.32557271
136MAPK signaling pathway_Homo sapiens_hsa040100.32023076
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31209122
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.29838966
139Salivary secretion_Homo sapiens_hsa049700.29760632
140HTLV-I infection_Homo sapiens_hsa051660.29719358
141Complement and coagulation cascades_Homo sapiens_hsa046100.28841321
142Insulin signaling pathway_Homo sapiens_hsa049100.27709017
143Chemical carcinogenesis_Homo sapiens_hsa052040.26279575
144Pancreatic secretion_Homo sapiens_hsa049720.25933255

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