DSN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.60833792
2mitotic metaphase plate congression (GO:0007080)5.52035872
3attachment of spindle microtubules to kinetochore (GO:0008608)5.05260611
4protein localization to chromosome, centromeric region (GO:0071459)5.03931163
5DNA replication checkpoint (GO:0000076)4.97854158
6metaphase plate congression (GO:0051310)4.87838999
7mitotic chromosome condensation (GO:0007076)4.87220077
8CENP-A containing nucleosome assembly (GO:0034080)4.74644543
9kinetochore organization (GO:0051383)4.64919353
10chromatin remodeling at centromere (GO:0031055)4.64525011
11meiotic chromosome segregation (GO:0045132)4.57400835
12DNA replication initiation (GO:0006270)4.57232475
13DNA strand elongation involved in DNA replication (GO:0006271)4.50047686
14mitotic sister chromatid segregation (GO:0000070)4.44375304
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.43202349
16establishment of chromosome localization (GO:0051303)4.42661222
17DNA strand elongation (GO:0022616)4.32308082
18DNA replication-independent nucleosome assembly (GO:0006336)4.31220937
19DNA replication-independent nucleosome organization (GO:0034724)4.31220937
20telomere maintenance via semi-conservative replication (GO:0032201)4.27849453
21regulation of spindle organization (GO:0090224)4.24985642
22establishment of integrated proviral latency (GO:0075713)4.23835909
23kinetochore assembly (GO:0051382)4.20139723
24telomere maintenance via recombination (GO:0000722)4.16499502
25histone exchange (GO:0043486)4.09969695
26DNA ligation (GO:0006266)4.08687792
27mitotic nuclear envelope disassembly (GO:0007077)4.03737890
28positive regulation of chromosome segregation (GO:0051984)4.03356266
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.02897103
30spindle checkpoint (GO:0031577)4.00748822
31sister chromatid segregation (GO:0000819)4.00248103
32mitotic recombination (GO:0006312)4.00241006
33protein K6-linked ubiquitination (GO:0085020)3.99356887
34protein localization to chromosome (GO:0034502)3.98012460
35deoxyribonucleotide biosynthetic process (GO:0009263)3.94494156
36nuclear pore complex assembly (GO:0051292)3.91625935
37nuclear pore organization (GO:0006999)3.90519723
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.85002557
39regulation of chromosome segregation (GO:0051983)3.84047495
40regulation of DNA endoreduplication (GO:0032875)3.82991597
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.79208803
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.78935176
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.78935176
44negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.77445782
45negative regulation of chromosome segregation (GO:0051985)3.76474397
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.75977505
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.74155815
48negative regulation of sister chromatid segregation (GO:0033046)3.74155815
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.74155815
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.74155815
51spindle assembly checkpoint (GO:0071173)3.73888950
52regulation of mitotic metaphase/anaphase transition (GO:0030071)3.73418501
53membrane disassembly (GO:0030397)3.73209720
54nuclear envelope disassembly (GO:0051081)3.73209720
55regulation of mitotic spindle organization (GO:0060236)3.70141896
56mitotic spindle checkpoint (GO:0071174)3.69612257
57mitotic spindle assembly checkpoint (GO:0007094)3.67156300
58DNA unwinding involved in DNA replication (GO:0006268)3.64906197
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.64634339
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.64634339
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.64634339
62DNA replication-dependent nucleosome organization (GO:0034723)3.59935640
63DNA replication-dependent nucleosome assembly (GO:0006335)3.59935640
64positive regulation of histone H3-K4 methylation (GO:0051571)3.59718607
65* chromosome segregation (GO:0007059)3.58324867
66telomere maintenance via telomere lengthening (GO:0010833)3.57778015
67regulation of sister chromatid segregation (GO:0033045)3.56129534
68regulation of mitotic sister chromatid separation (GO:0010965)3.56129534
69regulation of mitotic sister chromatid segregation (GO:0033047)3.56129534
70mitotic sister chromatid cohesion (GO:0007064)3.52236539
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45157258
72regulation of centrosome cycle (GO:0046605)3.43642655
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.43082972
74synapsis (GO:0007129)3.43076711
75DNA topological change (GO:0006265)3.42885511
76chromatin assembly or disassembly (GO:0006333)3.42784591
77DNA catabolic process, exonucleolytic (GO:0000738)3.36858657
78piRNA metabolic process (GO:0034587)3.35766404
79purine nucleobase biosynthetic process (GO:0009113)3.35161949
80proteasome assembly (GO:0043248)3.35045849
81nucleobase biosynthetic process (GO:0046112)3.34945019
82base-excision repair (GO:0006284)3.30821380
83pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.30704081
84mitotic G2/M transition checkpoint (GO:0044818)3.30654172
852-deoxyribonucleotide biosynthetic process (GO:0009265)3.30283570
86deoxyribose phosphate biosynthetic process (GO:0046385)3.30283570
87double-strand break repair via nonhomologous end joining (GO:0006303)3.29770452
88non-recombinational repair (GO:0000726)3.29770452
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.28658712
90regulation of sister chromatid cohesion (GO:0007063)3.28155641
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27837618
92histone-serine phosphorylation (GO:0035404)3.27599013
93establishment of viral latency (GO:0019043)3.26723683
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26551680
95DNA synthesis involved in DNA repair (GO:0000731)3.26428629
96G1/S transition of mitotic cell cycle (GO:0000082)3.24200413
97cell cycle G1/S phase transition (GO:0044843)3.24200413
98DNA double-strand break processing (GO:0000729)3.23908450
99microtubule depolymerization (GO:0007019)3.23787674
100postreplication repair (GO:0006301)3.21167341
101maturation of 5.8S rRNA (GO:0000460)3.20712051
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20039765
103regulation of centriole replication (GO:0046599)3.19337170
104ATP-dependent chromatin remodeling (GO:0043044)3.18261292
105mismatch repair (GO:0006298)3.17084539
106regulation of spindle checkpoint (GO:0090231)3.15909352
107ribosomal small subunit assembly (GO:0000028)3.11425535
108chromosome condensation (GO:0030261)3.10674283
109pore complex assembly (GO:0046931)3.10392485
110negative regulation of mitosis (GO:0045839)3.04388763
111telomere maintenance (GO:0000723)3.02366825
112ribosome assembly (GO:0042255)3.00906324
113* mitotic cell cycle (GO:0000278)3.00671902
114telomere organization (GO:0032200)3.00221673
115meiotic cell cycle (GO:0051321)2.99842815
116monoubiquitinated protein deubiquitination (GO:0035520)2.97833783
117ribosome biogenesis (GO:0042254)2.96187314
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.95824272
119nuclear envelope organization (GO:0006998)2.95266011
120inner cell mass cell proliferation (GO:0001833)2.94866231
121translesion synthesis (GO:0019985)2.93813725
122DNA packaging (GO:0006323)2.91154145
123chromosome organization (GO:0051276)2.89636412
124replication fork processing (GO:0031297)2.88775769
125transcription-coupled nucleotide-excision repair (GO:0006283)2.88062730
126regulation of double-strand break repair (GO:2000779)2.87067210
127resolution of meiotic recombination intermediates (GO:0000712)2.86153905
128sister chromatid cohesion (GO:0007062)2.86144767
129IMP biosynthetic process (GO:0006188)2.86057204
130negative regulation of nuclear division (GO:0051784)2.85392780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.88413433
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.56405307
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.19997778
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.45450871
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.07831003
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07796291
7AR_21909140_ChIP-Seq_LNCAP_Human2.94917441
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60452219
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.48492052
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47395067
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.46786237
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.45821460
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42757165
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39732965
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36379236
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36170539
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.29681847
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29472617
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25012255
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18699403
21VDR_23849224_ChIP-Seq_CD4+_Human2.11875782
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09451121
23E2F7_22180533_ChIP-Seq_HELA_Human10.4425845
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99269261
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91576397
26* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91246566
27XRN2_22483619_ChIP-Seq_HELA_Human1.90918530
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90828131
29FOXP3_21729870_ChIP-Seq_TREG_Human1.89417432
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.84559057
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82651389
32* GABP_19822575_ChIP-Seq_HepG2_Human1.77065628
33DCP1A_22483619_ChIP-Seq_HELA_Human1.71734049
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69576171
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.66649728
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65876754
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63531071
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.62823089
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62422911
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58934711
41TTF2_22483619_ChIP-Seq_HELA_Human1.58887919
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57908432
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57088632
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51652279
45ELK1_19687146_ChIP-ChIP_HELA_Human1.51376549
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51354517
47CIITA_25753668_ChIP-Seq_RAJI_Human1.51009397
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45988514
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42115523
50KDM5A_27292631_Chip-Seq_BREAST_Human1.40415213
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34467068
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33619883
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30830575
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.30308782
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26383625
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25508196
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25147046
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25122660
59MYC_22102868_ChIP-Seq_BL_Human1.25114100
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21429399
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18263426
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.18262465
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16953068
64* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16661104
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12383605
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11122600
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09610330
68MYC_18940864_ChIP-ChIP_HL60_Human1.08475625
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05702333
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05194479
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03766684
72* YY1_21170310_ChIP-Seq_MESCs_Mouse1.02698790
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00086332
74SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97208880
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95879888
76* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94743703
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94500936
78TFEB_21752829_ChIP-Seq_HELA_Human0.94154771
79SPI1_23547873_ChIP-Seq_NB4_Human0.89609799
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88610388
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88369474
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88330774
83NANOG_16153702_ChIP-ChIP_HESCs_Human0.87364786
84KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87122763
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86958951
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86227597
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86163592
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.84355415
89IRF1_19129219_ChIP-ChIP_H3396_Human0.82340231
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80126847
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78838349
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.78740970
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78261047
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77923599
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72655177
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.69826126
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68275229
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.67975762
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67885508
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.67735170
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.67007628
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66749802
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.66538772
104* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.66296438
105EWS_26573619_Chip-Seq_HEK293_Human0.66147617
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65573263
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.64730681
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.64251668
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.64107867
110MYB_26560356_Chip-Seq_TH1_Human0.62685498
111TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.62355746
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.59505989
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.58987189
114CHD1_26751641_Chip-Seq_LNCaP_Human0.58129346
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.57801738
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.57203386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.46479478
2MP0010094_abnormal_chromosome_stability5.22618765
3MP0003111_abnormal_nucleus_morphology4.79158443
4MP0003077_abnormal_cell_cycle4.15236632
5MP0008057_abnormal_DNA_replication4.04081979
6MP0004957_abnormal_blastocyst_morpholog3.79643304
7MP0008058_abnormal_DNA_repair3.65006934
8MP0008877_abnormal_DNA_methylation3.35347823
9MP0008007_abnormal_cellular_replicative3.12528349
10MP0003718_maternal_effect2.59877530
11MP0008932_abnormal_embryonic_tissue2.53015961
12MP0003806_abnormal_nucleotide_metabolis2.39072848
13MP0002396_abnormal_hematopoietic_system2.23644717
14MP0000350_abnormal_cell_proliferation2.10026291
15MP0003123_paternal_imprinting2.07799923
16MP0001730_embryonic_growth_arrest2.03654362
17MP0003786_premature_aging2.01618895
18MP0002210_abnormal_sex_determination1.90923236
19MP0010307_abnormal_tumor_latency1.84275993
20MP0001929_abnormal_gametogenesis1.75838804
21MP0000490_abnormal_crypts_of1.66312541
22MP0001672_abnormal_embryogenesis/_devel1.62674672
23MP0005380_embryogenesis_phenotype1.62674672
24MP0004808_abnormal_hematopoietic_stem1.60569975
25MP0001119_abnormal_female_reproductive1.59742822
26MP0003121_genomic_imprinting1.58426667
27MP0001697_abnormal_embryo_size1.54272896
28MP0000653_abnormal_sex_gland1.53952881
29MP0001145_abnormal_male_reproductive1.49407245
30MP0005397_hematopoietic_system_phenotyp1.43472157
31MP0001545_abnormal_hematopoietic_system1.43472157
32MP0002019_abnormal_tumor_incidence1.41084144
33MP0000313_abnormal_cell_death1.40558185
34MP0002085_abnormal_embryonic_tissue1.39880474
35MP0002102_abnormal_ear_morphology1.38458190
36MP0003984_embryonic_growth_retardation1.38103531
37MP0002080_prenatal_lethality1.33439932
38MP0002088_abnormal_embryonic_growth/wei1.33036527
39MP0010352_gastrointestinal_tract_polyps1.30485190
40MP0006292_abnormal_olfactory_placode1.30370366
41MP0003763_abnormal_thymus_physiology1.28810764
42MP0003315_abnormal_perineum_morphology1.28674471
43MP0010030_abnormal_orbit_morphology1.24691793
44MP0002084_abnormal_developmental_patter1.24604321
45MP0003950_abnormal_plasma_membrane1.21173023
46MP0002086_abnormal_extraembryonic_tissu1.15997177
47MP0003699_abnormal_female_reproductive1.15387023
48MP0003186_abnormal_redox_activity1.13044606
49MP0000358_abnormal_cell_content/1.11422915
50MP0009333_abnormal_splenocyte_physiolog1.09530158
51MP0006036_abnormal_mitochondrial_physio1.07443068
52MP0002398_abnormal_bone_marrow1.06985284
53MP0002938_white_spotting1.06666199
54MP0003937_abnormal_limbs/digits/tail_de1.05882861
55MP0006072_abnormal_retinal_apoptosis1.04521907
56MP0003787_abnormal_imprinting1.03863528
57MP0000703_abnormal_thymus_morphology1.01517397
58MP0009697_abnormal_copulation0.98946246
59MP0003567_abnormal_fetal_cardiomyocyte0.98898310
60MP0004197_abnormal_fetal_growth/weight/0.98695754
61MP0006035_abnormal_mitochondrial_morpho0.97634060
62MP0005389_reproductive_system_phenotype0.97408904
63MP0000566_synostosis0.96456969
64MP0000372_irregular_coat_pigmentation0.96133470
65MP0005451_abnormal_body_composition0.94519582
66MP0002160_abnormal_reproductive_system0.90671124
67MP0000689_abnormal_spleen_morphology0.90389143
68MP0002722_abnormal_immune_system0.90292919
69MP0003698_abnormal_male_reproductive0.90039649
70MP0002161_abnormal_fertility/fecundity0.87489766
71MP0009278_abnormal_bone_marrow0.85278581
72MP0008995_early_reproductive_senescence0.84709423
73MP0005395_other_phenotype0.83333216
74MP0005076_abnormal_cell_differentiation0.83294489
75MP0000015_abnormal_ear_pigmentation0.82811776
76MP0009053_abnormal_anal_canal0.82752546
77MP0001915_intracranial_hemorrhage0.79580043
78MP0005621_abnormal_cell_physiology0.79535048
79MP0003890_abnormal_embryonic-extraembry0.78706700
80MP0005501_abnormal_skin_physiology0.77968920
81MP0001919_abnormal_reproductive_system0.77334290
82MP0002697_abnormal_eye_size0.76761877
83MP0003943_abnormal_hepatobiliary_system0.76704964
84MP0002429_abnormal_blood_cell0.75297590
85MP0005384_cellular_phenotype0.74842401
86MP0003878_abnormal_ear_physiology0.74572767
87MP0005377_hearing/vestibular/ear_phenot0.74572767
88MP0003136_yellow_coat_color0.73435621
89MP0001764_abnormal_homeostasis0.72882854
90MP0001293_anophthalmia0.71803434
91MP0002095_abnormal_skin_pigmentation0.71759213
92MP0008260_abnormal_autophagy0.69538509
93MP0002163_abnormal_gland_morphology0.69320624
94MP0009379_abnormal_foot_pigmentation0.68158793
95MP0001346_abnormal_lacrimal_gland0.67996222
96MP0005408_hypopigmentation0.66082888
97MP0003119_abnormal_digestive_system0.65621674
98MP0000716_abnormal_immune_system0.64342257
99MP0005075_abnormal_melanosome_morpholog0.63943774
100MP0003656_abnormal_erythrocyte_physiolo0.63569851
101MP0004264_abnormal_extraembryonic_tissu0.63144968
102MP0009672_abnormal_birth_weight0.62465724
103MP0000858_altered_metastatic_potential0.60330383
104MP0005174_abnormal_tail_pigmentation0.60122599
105MP0009703_decreased_birth_body0.59385883
106MP0002075_abnormal_coat/hair_pigmentati0.59183279
107MP0003941_abnormal_skin_development0.59119320
108MP0000465_gastrointestinal_hemorrhage0.58428220
109MP0002877_abnormal_melanocyte_morpholog0.58393949
110MP0002111_abnormal_tail_morphology0.57204838
111MP0002653_abnormal_ependyma_morphology0.56900724
112MP0000432_abnormal_head_morphology0.56377986
113MP0006054_spinal_hemorrhage0.56004617
114MP0005171_absent_coat_pigmentation0.55835805
115MP0008789_abnormal_olfactory_epithelium0.55702474
116MP0000428_abnormal_craniofacial_morphol0.55337503
117MP0001186_pigmentation_phenotype0.54949067
118MP0005266_abnormal_metabolism0.54712540
119MP0001853_heart_inflammation0.54314818
120MP0003936_abnormal_reproductive_system0.53923453
121MP0005023_abnormal_wound_healing0.53207122
122MP0002132_abnormal_respiratory_system0.53101052
123MP0002233_abnormal_nose_morphology0.50928004
124MP0003861_abnormal_nervous_system0.50901110
125MP0001881_abnormal_mammary_gland0.50880603
126MP0001286_abnormal_eye_development0.50876697
127MP0001800_abnormal_humoral_immune0.50671819
128MP0000569_abnormal_digit_pigmentation0.50663914
129MP0005499_abnormal_olfactory_system0.50498583
130MP0005394_taste/olfaction_phenotype0.50498583
131MP0004147_increased_porphyrin_level0.50487062
132MP0001324_abnormal_eye_pigmentation0.49651708

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.77839948
2Chromsome breakage (HP:0040012)5.50670620
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.36925331
4Abnormality of chromosome stability (HP:0003220)4.23089758
5Breast hypoplasia (HP:0003187)4.02808437
6Meckel diverticulum (HP:0002245)3.96922890
7Abnormality of the preputium (HP:0100587)3.89975040
8Patellar aplasia (HP:0006443)3.83699962
9Abnormality of the ileum (HP:0001549)3.82650145
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.78316644
11Aplasia/Hypoplasia of the patella (HP:0006498)3.57741792
12Impulsivity (HP:0100710)3.42655694
13Duodenal stenosis (HP:0100867)3.37091753
14Small intestinal stenosis (HP:0012848)3.37091753
15Myelodysplasia (HP:0002863)3.23592460
16Ectopic kidney (HP:0000086)3.15155205
17Degeneration of anterior horn cells (HP:0002398)2.96883776
18Abnormality of the anterior horn cell (HP:0006802)2.96883776
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90306244
20Facial hemangioma (HP:0000329)2.88230959
21Sloping forehead (HP:0000340)2.87167277
22Acute necrotizing encephalopathy (HP:0006965)2.86031953
23Microvesicular hepatic steatosis (HP:0001414)2.83576972
24Clubbing of toes (HP:0100760)2.80595598
25Carpal bone hypoplasia (HP:0001498)2.79639510
26Abnormality of the carotid arteries (HP:0005344)2.75158146
27Abnormal mitochondria in muscle tissue (HP:0008316)2.71909618
28Selective tooth agenesis (HP:0001592)2.68600025
29Bone marrow hypocellularity (HP:0005528)2.68550225
30Abnormality of the duodenum (HP:0002246)2.67997018
31Absent radius (HP:0003974)2.66239625
32Acute encephalopathy (HP:0006846)2.63812832
33Abnormal lung lobation (HP:0002101)2.62229056
34Reticulocytopenia (HP:0001896)2.57633326
35Nephroblastoma (Wilms tumor) (HP:0002667)2.57456473
36Medulloblastoma (HP:0002885)2.55736577
37Abnormality of cells of the erythroid lineage (HP:0012130)2.54449949
38Cerebral edema (HP:0002181)2.53691000
39Absent thumb (HP:0009777)2.50184896
40Volvulus (HP:0002580)2.47982180
41Absent forearm bone (HP:0003953)2.47927889
42Aplasia involving forearm bones (HP:0009822)2.47927889
43Abnormal number of erythroid precursors (HP:0012131)2.46697096
44Oral leukoplakia (HP:0002745)2.46187173
45Abnormality of the labia minora (HP:0012880)2.45826127
46Colon cancer (HP:0003003)2.45673798
47Aplastic anemia (HP:0001915)2.43902307
48Abnormality of cochlea (HP:0000375)2.43270147
49Supernumerary spleens (HP:0009799)2.43254739
50Short thumb (HP:0009778)2.43028617
51Increased nuchal translucency (HP:0010880)2.39119489
52Embryonal renal neoplasm (HP:0011794)2.37316638
53Abnormality of DNA repair (HP:0003254)2.35607829
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.35540647
55Abnormal spermatogenesis (HP:0008669)2.34937664
5611 pairs of ribs (HP:0000878)2.34680724
57Macrocytic anemia (HP:0001972)2.34035843
58Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33123161
59Rhabdomyosarcoma (HP:0002859)2.27199753
60Increased CSF lactate (HP:0002490)2.26264316
61Duplicated collecting system (HP:0000081)2.25838827
62Capillary hemangiomas (HP:0005306)2.24753517
63Premature ovarian failure (HP:0008209)2.23192072
64Triphalangeal thumb (HP:0001199)2.21839058
65Slender long bone (HP:0003100)2.19618519
66Pancytopenia (HP:0001876)2.18658096
67Mitochondrial inheritance (HP:0001427)2.18258054
68Cafe-au-lait spot (HP:0000957)2.17846956
69Male infertility (HP:0003251)2.17032593
70Rough bone trabeculation (HP:0100670)2.14694112
71Microretrognathia (HP:0000308)2.11005142
72Horseshoe kidney (HP:0000085)2.10850801
73Abnormality of the renal collecting system (HP:0004742)2.09528805
74Acute myeloid leukemia (HP:0004808)2.08797103
75Prominent nose (HP:0000448)2.08576599
76Progressive macrocephaly (HP:0004481)2.06749459
77Tracheoesophageal fistula (HP:0002575)2.03499153
78Short middle phalanx of the 5th finger (HP:0004220)2.03230417
79Multiple enchondromatosis (HP:0005701)2.02665984
80Secondary amenorrhea (HP:0000869)2.02610837
81Abnormality of methionine metabolism (HP:0010901)2.02147609
82Agnosia (HP:0010524)2.00387188
83Pallor (HP:0000980)1.98381533
84Atresia of the external auditory canal (HP:0000413)1.97898288
85Abnormal number of incisors (HP:0011064)1.96739801
86Ependymoma (HP:0002888)1.95992353
87Hepatocellular necrosis (HP:0001404)1.95710777
88Hepatic necrosis (HP:0002605)1.95262939
89Abnormality of chromosome segregation (HP:0002916)1.95071242
90Type 2 muscle fiber atrophy (HP:0003554)1.93462567
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93074477
92Type I transferrin isoform profile (HP:0003642)1.91776294
93Pulmonary fibrosis (HP:0002206)1.91647273
94Abnormality of the fingertips (HP:0001211)1.91265358
95Neoplasm of the colon (HP:0100273)1.90004484
96Premature graying of hair (HP:0002216)1.88908325
97Duplication of thumb phalanx (HP:0009942)1.88520140
98Increased serum lactate (HP:0002151)1.87452197
99Entropion (HP:0000621)1.87294867
100Morphological abnormality of the inner ear (HP:0011390)1.86998748
101Overlapping toe (HP:0001845)1.86766865
102Muscle fiber atrophy (HP:0100295)1.86675839
103Aplasia/Hypoplasia of the earlobes (HP:0009906)1.86230900
104Neoplasm of the pancreas (HP:0002894)1.85163330
105Abnormality of pyrimidine metabolism (HP:0004353)1.85068857
106High pitched voice (HP:0001620)1.82864107
107Oligodactyly (HP:0012165)1.82488297
108Proximal placement of thumb (HP:0009623)1.82060959
109Papillary thyroid carcinoma (HP:0002895)1.81582501
110Breast aplasia (HP:0100783)1.81573344
111Spinal muscular atrophy (HP:0007269)1.80939701
112Abnormality of the fetal cardiovascular system (HP:0010948)1.80928171
113Abnormal umbilical cord blood vessels (HP:0011403)1.80928171
114Single umbilical artery (HP:0001195)1.80928171
115Deviation of the thumb (HP:0009603)1.80549863
116Squamous cell carcinoma (HP:0002860)1.79951861
117Irregular epiphyses (HP:0010582)1.76543602
118Microglossia (HP:0000171)1.75470084
119Arteriovenous malformation (HP:0100026)1.75388818
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74841514
121Absent epiphyses (HP:0010577)1.74841514
122Facial cleft (HP:0002006)1.74151607
123Aplasia/Hypoplasia of the breasts (HP:0010311)1.74042105
124Small hand (HP:0200055)1.72863495
125Flat capital femoral epiphysis (HP:0003370)1.71915131
126Azoospermia (HP:0000027)1.71181840
127Abnormality of the prostate (HP:0008775)1.70963073
128Microtia (HP:0008551)1.69860318
129Increased hepatocellular lipid droplets (HP:0006565)1.69129718
130Cleft eyelid (HP:0000625)1.68955506
131Lymphoma (HP:0002665)1.68771079
132Long clavicles (HP:0000890)1.67110820
133Cortical dysplasia (HP:0002539)1.67009357
134Hypoplastic pelvis (HP:0008839)1.66709875
135Choanal atresia (HP:0000453)1.66642131
136Hemivertebrae (HP:0002937)1.66226640
137Combined immunodeficiency (HP:0005387)1.65804393
138Abnormality of the umbilical cord (HP:0010881)1.65730828
139Cellular immunodeficiency (HP:0005374)1.65330165
140Prostate neoplasm (HP:0100787)1.64464160
141Abnormality of reticulocytes (HP:0004312)1.64201233
142Lactic acidosis (HP:0003128)1.63316979
143Reduced antithrombin III activity (HP:0001976)1.60379966
144Ureteral duplication (HP:0000073)1.58574956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.64978283
2MAP3K94.39845621
3BUB14.22496042
4VRK24.01595189
5WEE14.00077515
6PLK43.64593525
7TAF13.53166693
8TTK3.49527805
9NEK23.36351315
10BRSK23.09526053
11EIF2AK12.77048041
12ACVR1B2.62936891
13PBK2.60632828
14PLK12.48656458
15SRPK12.38433966
16CHEK22.13586138
17BRSK12.02935360
18* AURKB1.81888291
19PNCK1.76427762
20STK101.73220314
21ATR1.73142484
22PLK31.71529118
23ZAK1.69524107
24VRK11.61968664
25STK38L1.56416147
26MKNK11.55139671
27CDK81.54195007
28NEK11.52272804
29CDK71.47610731
30EEF2K1.43029950
31CDK41.42638734
32CCNB11.41277617
33STK31.39850664
34TLK11.36512990
35LATS11.34862818
36EIF2AK31.33464342
37MKNK21.33430674
38DYRK31.32271175
39MAP3K81.29220840
40TSSK61.29160271
41BRAF1.28736860
42MELK1.28299589
43CHEK11.27583492
44CDK121.27119809
45NME21.25093396
46SMG11.20799331
47AURKA1.19945259
48STK41.18422661
49RPS6KA41.13462935
50BCKDK1.10167713
51RPS6KB21.01361460
52ATM1.00371925
53STK160.99298280
54MAP3K60.98291882
55PASK0.96860840
56MST40.89180051
57TESK20.88478786
58BRD40.86937410
59PIM10.85439528
60ARAF0.84570220
61CDK20.82999180
62TRIM280.82955293
63EIF2AK20.80868298
64LATS20.76971912
65TGFBR10.74442154
66NME10.73715792
67NEK90.72022880
68CDK10.71053584
69MAP4K10.70552374
70TAOK30.69135332
71CDK90.69094406
72PDK20.67648137
73NUAK10.66036344
74STK240.61093363
75DAPK10.59751568
76CDK60.59618945
77KDR0.59548968
78CSNK1G30.57272696
79BMPR1B0.54715454
80MUSK0.54606146
81CSNK1G10.53848089
82IRAK30.53535245
83BMPR20.47496391
84MOS0.46857784
85LIMK10.46246217
86CSNK2A10.45181830
87JAK30.44706999
88CDK11A0.44546948
89MAPKAPK50.43273663
90CDK30.42683225
91TEC0.42153585
92TXK0.41595546
93MAPKAPK30.40422692
94MST1R0.40237411
95CLK10.39335977
96DYRK20.39206416
97PAK10.39069979
98CDK180.38625315
99CDK140.38576302
100RPS6KA50.38426815
101PRKCI0.37982003
102RAF10.37980460
103CDK150.37571050
104IRAK40.36929745
105INSRR0.36270848
106MAP3K100.34750369
107CSNK1A1L0.33443650
108PLK20.33141529
109CHUK0.33122332
110CSNK2A20.32704749
111PDK30.32237595
112PDK40.32237595
113CSNK1E0.30093351
114BTK0.29857711
115ERBB40.29270160
116TESK10.28474662
117MARK30.27823635
118CSNK1G20.27750743
119KIT0.27317727
120AKT10.26348470
121ZAP700.26157046
122SCYL20.25735295
123EPHA20.24996237
124FLT30.24970643
125NLK0.24930379
126MAP3K50.24008664
127PRKDC0.23417919
128MAPK140.23355660
129ABL20.23289213
130TAOK10.23261034
131AKT20.22394144
132MAPK110.19981663
133WNK30.19945852
134CDK190.19321778
135PAK40.15975256
136ALK0.14411814

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.90745423
2Mismatch repair_Homo sapiens_hsa034304.12476004
3Cell cycle_Homo sapiens_hsa041103.68461584
4Homologous recombination_Homo sapiens_hsa034403.54385156
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48719801
6Base excision repair_Homo sapiens_hsa034103.33292357
7Fanconi anemia pathway_Homo sapiens_hsa034603.03844203
8RNA transport_Homo sapiens_hsa030132.99761002
9Nucleotide excision repair_Homo sapiens_hsa034202.90471966
10RNA polymerase_Homo sapiens_hsa030202.87498499
11Spliceosome_Homo sapiens_hsa030402.76441050
12Basal transcription factors_Homo sapiens_hsa030222.65703175
13Non-homologous end-joining_Homo sapiens_hsa034502.49571141
14Pyrimidine metabolism_Homo sapiens_hsa002402.29134355
15RNA degradation_Homo sapiens_hsa030182.27059978
16p53 signaling pathway_Homo sapiens_hsa041152.13805981
17Vitamin B6 metabolism_Homo sapiens_hsa007502.13170058
18One carbon pool by folate_Homo sapiens_hsa006702.02219982
19Proteasome_Homo sapiens_hsa030501.89144016
20mRNA surveillance pathway_Homo sapiens_hsa030151.80369187
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77936435
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51159957
23Ribosome_Homo sapiens_hsa030101.49306285
24Purine metabolism_Homo sapiens_hsa002301.38902695
25Oocyte meiosis_Homo sapiens_hsa041141.37235723
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30766080
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29467191
28Oxidative phosphorylation_Homo sapiens_hsa001901.27304308
29Parkinsons disease_Homo sapiens_hsa050121.26078845
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20733667
31Pyruvate metabolism_Homo sapiens_hsa006201.19930773
32Systemic lupus erythematosus_Homo sapiens_hsa053221.16494532
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14368156
34Huntingtons disease_Homo sapiens_hsa050161.13370875
35Herpes simplex infection_Homo sapiens_hsa051681.12695357
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11021751
37Epstein-Barr virus infection_Homo sapiens_hsa051691.10472661
38Propanoate metabolism_Homo sapiens_hsa006401.02388628
39Fatty acid elongation_Homo sapiens_hsa000621.01450474
40Viral carcinogenesis_Homo sapiens_hsa052031.01032768
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00735549
42HTLV-I infection_Homo sapiens_hsa051660.90699431
43MicroRNAs in cancer_Homo sapiens_hsa052060.89352203
44Carbon metabolism_Homo sapiens_hsa012000.88279144
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85254909
46Folate biosynthesis_Homo sapiens_hsa007900.85170191
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80601196
48Steroid biosynthesis_Homo sapiens_hsa001000.77961929
49Small cell lung cancer_Homo sapiens_hsa052220.75533551
50Antigen processing and presentation_Homo sapiens_hsa046120.73453644
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72634677
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71815331
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67060281
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66213001
55Alzheimers disease_Homo sapiens_hsa050100.64772328
56Primary immunodeficiency_Homo sapiens_hsa053400.62152471
57TGF-beta signaling pathway_Homo sapiens_hsa043500.60285769
58Pentose phosphate pathway_Homo sapiens_hsa000300.59012089
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.57043286
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.56387260
61Measles_Homo sapiens_hsa051620.55491653
62Selenocompound metabolism_Homo sapiens_hsa004500.55413083
63Hepatitis B_Homo sapiens_hsa051610.54875801
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53217024
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52477712
66Pancreatic cancer_Homo sapiens_hsa052120.52217821
67Apoptosis_Homo sapiens_hsa042100.51501635
68Colorectal cancer_Homo sapiens_hsa052100.51294786
69Metabolic pathways_Homo sapiens_hsa011000.51125415
70Thyroid cancer_Homo sapiens_hsa052160.47327737
71Hematopoietic cell lineage_Homo sapiens_hsa046400.47005527
72Notch signaling pathway_Homo sapiens_hsa043300.46899212
73Regulation of autophagy_Homo sapiens_hsa041400.46283994
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44386829
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.43869457
76Influenza A_Homo sapiens_hsa051640.43244234
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39972954
78Fatty acid metabolism_Homo sapiens_hsa012120.39820110
79Chronic myeloid leukemia_Homo sapiens_hsa052200.39411091
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.39403053
81Alcoholism_Homo sapiens_hsa050340.39295150
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39126389
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38434612
84FoxO signaling pathway_Homo sapiens_hsa040680.37735454
85Legionellosis_Homo sapiens_hsa051340.36277558
86Hippo signaling pathway_Homo sapiens_hsa043900.35566479
87Protein export_Homo sapiens_hsa030600.35368154
88Shigellosis_Homo sapiens_hsa051310.35175748
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34254407
90Linoleic acid metabolism_Homo sapiens_hsa005910.33804025
91Butanoate metabolism_Homo sapiens_hsa006500.30788648
92N-Glycan biosynthesis_Homo sapiens_hsa005100.30676565
93Biosynthesis of amino acids_Homo sapiens_hsa012300.29630671
94Arachidonic acid metabolism_Homo sapiens_hsa005900.29224625
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28496695
96Prostate cancer_Homo sapiens_hsa052150.28319830
97Circadian rhythm_Homo sapiens_hsa047100.27600682
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27347079
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27126629
100Hedgehog signaling pathway_Homo sapiens_hsa043400.27084991
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.27029658
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26838830
103Pathways in cancer_Homo sapiens_hsa052000.26562377
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.26268874
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26158533
106Ovarian steroidogenesis_Homo sapiens_hsa049130.25757834
107Sulfur relay system_Homo sapiens_hsa041220.24891592
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24061171
109Fatty acid degradation_Homo sapiens_hsa000710.24035818
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23564095
111Basal cell carcinoma_Homo sapiens_hsa052170.23073889
112Adherens junction_Homo sapiens_hsa045200.22471048
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22459701
114Lysine degradation_Homo sapiens_hsa003100.19813130
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19369922
116Bladder cancer_Homo sapiens_hsa052190.18410796
117Glutathione metabolism_Homo sapiens_hsa004800.17088186
118Peroxisome_Homo sapiens_hsa041460.16962096
119Wnt signaling pathway_Homo sapiens_hsa043100.16854407
120Viral myocarditis_Homo sapiens_hsa054160.16047475
121Non-small cell lung cancer_Homo sapiens_hsa052230.15566440
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.15354790
123Galactose metabolism_Homo sapiens_hsa000520.15177753
124Vitamin digestion and absorption_Homo sapiens_hsa049770.14710971
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13333935
126Acute myeloid leukemia_Homo sapiens_hsa052210.11678019
127Fructose and mannose metabolism_Homo sapiens_hsa000510.11493933
128mTOR signaling pathway_Homo sapiens_hsa041500.11475449
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11307971
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10719211
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10185778
132Sulfur metabolism_Homo sapiens_hsa009200.10175893
133Other glycan degradation_Homo sapiens_hsa005110.09216612
134Tryptophan metabolism_Homo sapiens_hsa003800.08658578
135Caffeine metabolism_Homo sapiens_hsa002320.06328458
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.04306623
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.04202254
138Melanoma_Homo sapiens_hsa052180.03579280

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