DSP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.25887812
2keratinization (GO:0031424)7.84032096
3* bundle of His cell to Purkinje myocyte communication (GO:0086069)7.75534743
4establishment of skin barrier (GO:0061436)7.70476692
5hair cycle (GO:0042633)7.53245486
6molting cycle (GO:0042303)7.53245486
7regulation of water loss via skin (GO:0033561)7.49116464
8sarcomere organization (GO:0045214)6.09396577
9cardiac myofibril assembly (GO:0055003)5.64482316
10regulation of cardioblast differentiation (GO:0051890)5.38003886
11multicellular organismal water homeostasis (GO:0050891)5.22806357
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.96769507
13* ventricular cardiac muscle cell action potential (GO:0086005)4.95034974
14* keratinocyte differentiation (GO:0030216)4.82739810
15myofibril assembly (GO:0030239)4.81288119
16atrioventricular valve morphogenesis (GO:0003181)4.63526134
17polarized epithelial cell differentiation (GO:0030859)4.58100979
18keratinocyte proliferation (GO:0043616)4.49706632
19negative regulation of potassium ion transmembrane transport (GO:1901380)4.35788133
20cardiac muscle contraction (GO:0060048)4.35414739
21water homeostasis (GO:0030104)4.34949365
22plasma membrane repair (GO:0001778)4.33909228
23actin-myosin filament sliding (GO:0033275)4.29336893
24muscle filament sliding (GO:0030049)4.29336893
25cardiac muscle cell development (GO:0055013)4.15695689
26* intermediate filament organization (GO:0045109)4.10266076
27regulation of keratinocyte proliferation (GO:0010837)4.08058973
28cardiac cell development (GO:0055006)4.05886246
29* cell communication involved in cardiac conduction (GO:0086065)4.05074216
30actomyosin structure organization (GO:0031032)3.99415042
31* epidermis development (GO:0008544)3.96503915
32epithelial cell-cell adhesion (GO:0090136)3.95378890
33* cardiac muscle tissue morphogenesis (GO:0055008)3.90160812
34actin-mediated cell contraction (GO:0070252)3.89903319
35* peptide cross-linking (GO:0018149)3.89830202
36skin morphogenesis (GO:0043589)3.87024113
37positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.85382109
38* epidermal cell differentiation (GO:0009913)3.81747693
39surfactant homeostasis (GO:0043129)3.80954685
40regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.80630717
41* ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.79068735
42regulation of skeletal muscle contraction (GO:0014819)3.76784441
43establishment of tissue polarity (GO:0007164)3.74661539
44establishment of planar polarity (GO:0001736)3.74661539
45cell-substrate junction assembly (GO:0007044)3.69100127
46virion attachment to host cell (GO:0019062)3.68843486
47adhesion of symbiont to host cell (GO:0044650)3.68843486
48cardiac muscle hypertrophy (GO:0003300)3.65251187
49ectoderm development (GO:0007398)3.60609311
50* muscle tissue morphogenesis (GO:0060415)3.55379321
51striated muscle hypertrophy (GO:0014897)3.53095233
52cardiac right ventricle morphogenesis (GO:0003215)3.48887339
53regulation of actin filament-based movement (GO:1903115)3.44393256
54regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.42919770
55adult heart development (GO:0007512)3.42129037
56chemical homeostasis within a tissue (GO:0048875)3.41094231
57carnitine shuttle (GO:0006853)3.38240262
58heart trabecula formation (GO:0060347)3.36985395
59regulation of keratinocyte differentiation (GO:0045616)3.36496983
60negative regulation of cell fate specification (GO:0009996)3.32884247
61positive regulation of epidermal cell differentiation (GO:0045606)3.32328211
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.28286414
63regulation of transforming growth factor beta2 production (GO:0032909)3.28039848
64regulation of cholesterol homeostasis (GO:2000188)3.22683039
65actin filament-based movement (GO:0030048)3.20927172
66regulation of sarcomere organization (GO:0060297)3.17506822
67regulation of the force of heart contraction (GO:0002026)3.16807569
68striated muscle contraction (GO:0006941)3.15782393
69epithelial cell differentiation involved in prostate gland development (GO:0060742)3.14344820
70* regulation of heart rate by cardiac conduction (GO:0086091)3.09266194
71cell adhesion mediated by integrin (GO:0033627)3.07282100
72* cardiac conduction (GO:0061337)3.04170186
73negative regulation of keratinocyte proliferation (GO:0010839)3.03866787
74positive regulation of epidermis development (GO:0045684)3.03845961
75* cardiac muscle cell action potential involved in contraction (GO:0086002)3.02471491
76muscle hypertrophy (GO:0014896)3.02343093
77tricarboxylic acid cycle (GO:0006099)3.01971259
78regulation of relaxation of muscle (GO:1901077)3.00501683
79* cardiac muscle cell action potential (GO:0086001)2.97646098
80COPI coating of Golgi vesicle (GO:0048205)2.94748615
81Golgi transport vesicle coating (GO:0048200)2.94748615
82adhesion of symbiont to host (GO:0044406)2.94725295
83fatty acid transmembrane transport (GO:1902001)2.92177142
84COPII vesicle coating (GO:0048208)2.87979366
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.86808965
86regulation of transforming growth factor beta1 production (GO:0032908)2.85649581
87outflow tract septum morphogenesis (GO:0003148)2.85615515
88relaxation of cardiac muscle (GO:0055119)2.78466323
89regulation of striated muscle contraction (GO:0006942)2.78315363
90cell-cell junction assembly (GO:0007043)2.78280185
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76391282
92lateral sprouting from an epithelium (GO:0060601)2.72761599
93cytoskeletal anchoring at plasma membrane (GO:0007016)2.72536879
94heart valve morphogenesis (GO:0003179)2.71881098
95cardiac muscle cell proliferation (GO:0060038)2.71513943
96linoleic acid metabolic process (GO:0043651)2.71283946
97genitalia morphogenesis (GO:0035112)2.66657823
98planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66539883
99gap junction assembly (GO:0016264)2.66476773
100positive regulation of keratinocyte differentiation (GO:0045618)2.64073758
101regulation of epidermis development (GO:0045682)2.63624526
102carnitine transmembrane transport (GO:1902603)2.63568683
103* epithelium development (GO:0060429)2.62834637
104negative regulation of striated muscle cell apoptotic process (GO:0010664)2.62322015
105regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.62129386
106sphingoid metabolic process (GO:0046519)2.62117593
107* regulation of heart rate (GO:0002027)2.61300602
108trabecula formation (GO:0060343)2.59276988
109cardiac muscle hypertrophy in response to stress (GO:0014898)2.58890995
110muscle hypertrophy in response to stress (GO:0003299)2.58890995
111cardiac muscle adaptation (GO:0014887)2.58890995
112cell junction assembly (GO:0034329)2.58273461
113branching involved in mammary gland duct morphogenesis (GO:0060444)2.57876017
114* intermediate filament cytoskeleton organization (GO:0045104)2.56639034
115dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.54554862
116regulation of transforming growth factor beta production (GO:0071634)2.53533802
117* intermediate filament-based process (GO:0045103)2.52837427
118phospholipid efflux (GO:0033700)2.52025749
119negative regulation of hormone biosynthetic process (GO:0032353)2.51918622
120negative regulation of cell fate commitment (GO:0010454)2.51915050
121tight junction assembly (GO:0070830)2.48022404
122positive regulation of hormone metabolic process (GO:0032352)2.47325868
123establishment of apical/basal cell polarity (GO:0035089)2.46646272
124regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46393875
125sphingosine metabolic process (GO:0006670)2.44901226
126striated muscle cell development (GO:0055002)2.44357979
127keratinocyte development (GO:0003334)2.44009983
128regulation of epidermal cell differentiation (GO:0045604)2.43406659
129intestinal epithelial cell development (GO:0060576)2.41822296
130skin development (GO:0043588)2.41589491
131glandular epithelial cell differentiation (GO:0002067)2.41526981
132carnitine transport (GO:0015879)2.41398970
133amino-acid betaine transport (GO:0015838)2.41398970
134* cell junction organization (GO:0034330)2.40543424
135negative regulation of hormone metabolic process (GO:0032351)2.40383858
136regulation of cardioblast proliferation (GO:0003264)2.38950136
137regulation of hair follicle development (GO:0051797)2.36829682
138regulation of steroid hormone biosynthetic process (GO:0090030)2.36498698
139hair follicle morphogenesis (GO:0031069)2.32287918
140epithelial cell proliferation (GO:0050673)2.31977543
141negative regulation of chondrocyte differentiation (GO:0032331)2.30917785
142columnar/cuboidal epithelial cell development (GO:0002066)2.27503202
143hair cell differentiation (GO:0035315)2.27252643
144positive regulation of hormone biosynthetic process (GO:0046886)2.27186385
145regulation of glucocorticoid metabolic process (GO:0031943)2.26671999
146regulation of protein localization to cell surface (GO:2000008)2.25841479
147long-chain fatty acid biosynthetic process (GO:0042759)2.25759431
148molting cycle process (GO:0022404)2.23554560
149hair cycle process (GO:0022405)2.23554560
150apical protein localization (GO:0045176)2.22738924
151basement membrane organization (GO:0071711)2.22571045
152peptidyl-glutamic acid carboxylation (GO:0017187)2.21925684
153protein carboxylation (GO:0018214)2.21925684
154very-low-density lipoprotein particle assembly (GO:0034379)2.21301374
155morphogenesis of embryonic epithelium (GO:0016331)2.21169934
156Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.21137570
157epithelial cell fate commitment (GO:0072148)2.20334562
158regulation of phospholipase A2 activity (GO:0032429)2.20245973
159intestinal cholesterol absorption (GO:0030299)2.19943472
160auditory receptor cell differentiation (GO:0042491)2.19244909
161mesodermal cell differentiation (GO:0048333)2.18614859
162* desmosome organization (GO:0002934)10.3772237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.80750049
2ZNF263_19887448_ChIP-Seq_K562_Human2.98105871
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.88014446
4* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.64842802
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.40766569
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.38769645
7* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.38363701
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37936135
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.37797478
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.18405604
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.18119891
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.07881868
13TP63_17297297_ChIP-ChIP_HaCaT_Human12.3795220
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.98338274
15TBX20_22080862_ChIP-Seq_HEART_Mouse1.92432258
16TBX20_22328084_ChIP-Seq_HEART_Mouse1.92432258
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90335637
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89387849
19* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.86015279
20* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.86015279
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71205611
22* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56244881
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56151859
24* RUNX1_27514584_Chip-Seq_MCF-7_Human1.53586999
25* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53502960
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51838113
27AR_21909140_ChIP-Seq_LNCAP_Human1.50417795
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50190288
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49653126
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43558557
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43153048
32* RACK7_27058665_Chip-Seq_MCF-7_Human1.42178820
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.42022840
34* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40487829
35CLOCK_20551151_ChIP-Seq_293T_Human1.39974607
36ATF3_27146783_Chip-Seq_COLON_Human1.37723504
37* SOX2_20726797_ChIP-Seq_SW620_Human1.37567290
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37310009
39CJUN_26792858_Chip-Seq_BT549_Human1.35834383
40* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32947491
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.32127392
42* TP63_22573176_ChIP-Seq_HFKS_Human1.31049675
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30878997
44GATA4_25053715_ChIP-Seq_YYC3_Human1.28997727
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28556989
46GATA6_25053715_ChIP-Seq_YYC3_Human1.28138951
47* TP63_23658742_ChIP-Seq_EP156T_Human1.27398760
48AHR_22903824_ChIP-Seq_MCF-7_Human1.27099921
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.24799101
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24772087
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.23463487
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23319856
53* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20883474
54KLF5_25053715_ChIP-Seq_YYC3_Human1.19909386
55GATA3_24758297_ChIP-Seq_MCF-7_Human1.19190876
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14886411
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12990795
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12008309
59GATA1_22025678_ChIP-Seq_K562_Human1.11353399
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09116836
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.08164385
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06734760
63* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03278658
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03018004
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02787153
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02737739
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02626929
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01519482
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00890094
70GATA2_21666600_ChIP-Seq_HMVEC_Human0.99191188
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98987655
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98378661
73BCAT_22108803_ChIP-Seq_LS180_Human0.98234560
74* ISL1_27105846_Chip-Seq_CPCs_Mouse0.98219265
75FOXA1_25552417_ChIP-Seq_VCAP_Human0.97590663
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96163751
77ARNT_22903824_ChIP-Seq_MCF-7_Human0.93488514
78* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93269552
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92117228
80CTCF_27219007_Chip-Seq_Bcells_Human0.92075739
81EGR1_19032775_ChIP-ChIP_M12_Human0.91942141
82LXR_22292898_ChIP-Seq_THP-1_Human0.90403386
83RXR_22108803_ChIP-Seq_LS180_Human0.89459427
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89439293
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87484616
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86226402
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.86178448
88TP53_16413492_ChIP-PET_HCT116_Human0.85955887
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84934582
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84934582
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84449223
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.84291491
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84203167
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83007618
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82459500
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.82229864
97FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82143764
98TP53_18474530_ChIP-ChIP_U2OS_Human0.81103808
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79925418
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78865794
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.78784710
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78778633
103* FOXA2_19822575_ChIP-Seq_HepG2_Human0.76452282
104CHD1_26751641_Chip-Seq_LNCaP_Human0.76237139
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76130541
106* HNF4A_19822575_ChIP-Seq_HepG2_Human0.75682687
107P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.75002982
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74055513
109FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73649970
110AR_21572438_ChIP-Seq_LNCaP_Human0.72816789
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72733446
112GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71944726
113BRD4_25478319_ChIP-Seq_HGPS_Human0.71488135
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71049905
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.70941410
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70456800
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70315052
118CEBPB_22108803_ChIP-Seq_LS180_Human0.70236411
119* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.69469841
120* KDM2B_26808549_Chip-Seq_K562_Human0.68899793
121* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68859587
122* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67601008
123GATA2_19941826_ChIP-Seq_K562_Human0.67385255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.50830766
2MP0005275_abnormal_skin_tensile4.53821647
3MP0010234_abnormal_vibrissa_follicle4.42049396
4MP0000579_abnormal_nail_morphology4.26911218
5MP0003941_abnormal_skin_development3.54802153
6MP0002837_dystrophic_cardiac_calcinosis3.48728935
7MP0005501_abnormal_skin_physiology3.27679228
8MP0004084_abnormal_cardiac_muscle3.20454719
9MP0002254_reproductive_system_inflammat3.09183784
10MP0003705_abnormal_hypodermis_morpholog3.02707323
11MP0000383_abnormal_hair_follicle3.01881535
12MP0002098_abnormal_vibrissa_morphology3.00893643
13MP0010678_abnormal_skin_adnexa2.88251180
14MP0002060_abnormal_skin_morphology2.65117160
15MP0004215_abnormal_myocardial_fiber2.48416626
16MP0009780_abnormal_chondrocyte_physiolo2.44928730
17* MP0001216_abnormal_epidermal_layer2.43674240
18MP0000751_myopathy2.36856800
19MP0000647_abnormal_sebaceous_gland2.34941794
20MP0003453_abnormal_keratinocyte_physiol2.25589106
21MP0005330_cardiomyopathy2.19148662
22MP0004381_abnormal_hair_follicle2.16575708
23MP0000377_abnormal_hair_follicle2.15753112
24MP0010771_integument_phenotype2.06709288
25MP0000467_abnormal_esophagus_morphology2.05799220
26MP0004036_abnormal_muscle_relaxation2.04558412
27MP0002234_abnormal_pharynx_morphology1.99934162
28MP0003646_muscle_fatigue1.97596134
29MP0000427_abnormal_hair_cycle1.93043622
30MP0002972_abnormal_cardiac_muscle1.80919174
31MP0000762_abnormal_tongue_morphology1.79952309
32MP0004947_skin_inflammation1.67362370
33MP0000749_muscle_degeneration1.62791350
34MP0004087_abnormal_muscle_fiber1.60524821
35MP0005451_abnormal_body_composition1.59087774
36* MP0003566_abnormal_cell_adhesion1.58535244
37MP0000566_synostosis1.58111499
38MP0010630_abnormal_cardiac_muscle1.56437736
39MP0008775_abnormal_heart_ventricle1.56349705
40MP0004185_abnormal_adipocyte_glucose1.51044740
41MP0006138_congestive_heart_failure1.48816574
42MP0005385_cardiovascular_system_phenoty1.41038648
43MP0001544_abnormal_cardiovascular_syste1.41038648
44MP0000750_abnormal_muscle_regeneration1.39173100
45MP0003828_pulmonary_edema1.39000038
46MP0003137_abnormal_impulse_conducting1.35639065
47MP0005620_abnormal_muscle_contractility1.34764293
48MP0004782_abnormal_surfactant_physiolog1.34585473
49MP0001346_abnormal_lacrimal_gland1.29896897
50MP0009931_abnormal_skin_appearance1.23134400
51MP0004272_abnormal_basement_membrane1.22619717
52MP0005257_abnormal_intraocular_pressure1.21277283
53MP0004484_altered_response_of1.21069264
54MP0003950_abnormal_plasma_membrane1.16503156
55MP0001191_abnormal_skin_condition1.08170664
56MP0001243_abnormal_dermal_layer1.06061141
57MP0000462_abnormal_digestive_system1.04831597
58MP0000537_abnormal_urethra_morphology1.03792791
59MP0004085_abnormal_heartbeat1.01816171
60MP0002106_abnormal_muscle_physiology1.00370100
61MP0004130_abnormal_muscle_cell1.00366313
62MP0000367_abnormal_coat/_hair0.99978509
63MP0001849_ear_inflammation0.99912336
64MP0005666_abnormal_adipose_tissue0.99179544
65MP0000003_abnormal_adipose_tissue0.95477235
66MP0009384_cardiac_valve_regurgitation0.94539870
67MP0004264_abnormal_extraembryonic_tissu0.92893239
68MP0009053_abnormal_anal_canal0.92430663
69MP0003567_abnormal_fetal_cardiomyocyte0.88381858
70MP0005023_abnormal_wound_healing0.84690773
71MP0002269_muscular_atrophy0.84398966
72MP0005377_hearing/vestibular/ear_phenot0.82755097
73MP0003878_abnormal_ear_physiology0.82755097
74MP0005360_urolithiasis0.82700068
75MP0010352_gastrointestinal_tract_polyps0.80937006
76MP0002877_abnormal_melanocyte_morpholog0.79811397
77MP0005369_muscle_phenotype0.79512665
78MP0010368_abnormal_lymphatic_system0.78346265
79MP0001188_hyperpigmentation0.78266721
80MP0000013_abnormal_adipose_tissue0.76653223
81MP0002009_preneoplasia0.75889133
82MP0003221_abnormal_cardiomyocyte_apopto0.74842286
83MP0002127_abnormal_cardiovascular_syste0.73701097
84MP0002909_abnormal_adrenal_gland0.73593557
85MP0004019_abnormal_vitamin_homeostasis0.73586682
86MP0000516_abnormal_urinary_system0.71877761
87MP0005367_renal/urinary_system_phenotyp0.71877761
88MP0001784_abnormal_fluid_regulation0.71409617
89MP0003315_abnormal_perineum_morphology0.71284419
90MP0004885_abnormal_endolymph0.70658921
91MP0005187_abnormal_penis_morphology0.70483889
92MP0005375_adipose_tissue_phenotype0.70426356
93MP0000759_abnormal_skeletal_muscle0.70359900
94MP0002896_abnormal_bone_mineralization0.70299264
95MP0010030_abnormal_orbit_morphology0.69910279
96MP0004510_myositis0.69298401
97MP0002697_abnormal_eye_size0.68704063
98MP0005408_hypopigmentation0.68634686
99MP0005165_increased_susceptibility_to0.65779446
100MP0001299_abnormal_eye_distance/0.63618599
101MP0003191_abnormal_cellular_cholesterol0.63388328
102MP0005085_abnormal_gallbladder_physiolo0.62637255
103MP0002177_abnormal_outer_ear0.62494504
104MP0009379_abnormal_foot_pigmentation0.61698093
105MP0005365_abnormal_bile_salt0.61563659
106MP0002282_abnormal_trachea_morphology0.59844037
107MP0000678_abnormal_parathyroid_gland0.59094786
108MP0003123_paternal_imprinting0.58899810
109MP0000538_abnormal_urinary_bladder0.58820943
110MP0001666_abnormal_nutrient_absorption0.58400903
111MP0001851_eye_inflammation0.58098676
112MP0002089_abnormal_postnatal_growth/wei0.57897902
113MP0002111_abnormal_tail_morphology0.57681940
114MP0003868_abnormal_feces_composition0.57645151
115MP0001340_abnormal_eyelid_morphology0.56853051
116MP0000747_muscle_weakness0.56359006
117MP0000266_abnormal_heart_morphology0.56190619
118MP0006054_spinal_hemorrhage0.55616804
119MP0010329_abnormal_lipoprotein_level0.53681976
120MP0001661_extended_life_span0.51653820
121MP0000432_abnormal_head_morphology0.50302387
122MP0003937_abnormal_limbs/digits/tail_de0.49793284
123MP0005076_abnormal_cell_differentiation0.49650311
124MP0002233_abnormal_nose_morphology0.47196566
125MP0003122_maternal_imprinting0.46157148
126MP0000627_abnormal_mammary_gland0.45754222
127MP0008438_abnormal_cutaneous_collagen0.45701037
128MP0005248_abnormal_Harderian_gland0.45151870
129MP0003045_fibrosis0.44585716
130MP0004145_abnormal_muscle_electrophysio0.44110522
131MP0005623_abnormal_meninges_morphology0.43939169
132MP0003300_gastrointestinal_ulcer0.42178670
133MP0005409_darkened_coat_color0.41429397
134MP0003755_abnormal_palate_morphology0.40928235
135MP0002086_abnormal_extraembryonic_tissu0.40657784
136MP0003115_abnormal_respiratory_system0.40392245
137MP0003283_abnormal_digestive_organ0.40298058
138MP0002095_abnormal_skin_pigmentation0.39480266
139MP0009672_abnormal_birth_weight0.39334760
140MP0004197_abnormal_fetal_growth/weight/0.39121962

Predicted human phenotypes

RankGene SetZ-score
1* Right ventricular cardiomyopathy (HP:0011663)7.29277704
2Sudden death (HP:0001699)6.60615818
3* Ventricular tachycardia (HP:0004756)5.99166595
4Hypotrichosis (HP:0001006)5.92915092
5Onycholysis (HP:0001806)5.20392493
6Fragile nails (HP:0001808)4.97187730
7Pili torti (HP:0003777)4.96743846
8Abnormality of nail color (HP:0100643)4.96538356
9Hyporeflexia of lower limbs (HP:0002600)4.88929506
10* Woolly hair (HP:0002224)4.84254018
11* Plantar hyperkeratosis (HP:0007556)4.79380789
12Milia (HP:0001056)4.76950791
13Conjunctival hamartoma (HP:0100780)4.24719900
14Increased IgE level (HP:0003212)4.23675230
15Syncope (HP:0001279)4.15894350
16Abnormality of the axillary hair (HP:0100134)4.13833317
17Abnormality of secondary sexual hair (HP:0009888)4.13833317
18Atrial fibrillation (HP:0005110)3.97663920
19* Palmoplantar hyperkeratosis (HP:0000972)3.96218811
20* Palmoplantar keratoderma (HP:0000982)3.88809605
21Muscle fiber splitting (HP:0003555)3.84415459
22Thick nail (HP:0001805)3.82919007
23Increased connective tissue (HP:0009025)3.75836811
24Calf muscle hypertrophy (HP:0008981)3.73555629
25Primary atrial arrhythmia (HP:0001692)3.69894371
26Lipoatrophy (HP:0100578)3.68650456
27* Palmar hyperkeratosis (HP:0010765)3.68170042
28Supraventricular tachycardia (HP:0004755)3.54561464
29Absent eyelashes (HP:0000561)3.51147787
30Supraventricular arrhythmia (HP:0005115)3.49480890
31Abnormality of the calf musculature (HP:0001430)3.42104756
32Exercise-induced muscle cramps (HP:0003710)3.41523622
33Lip pit (HP:0100267)3.36092540
34Exercise-induced myalgia (HP:0003738)3.32357057
35Atrophic scars (HP:0001075)3.30237680
36Palpitations (HP:0001962)3.28722582
37Distal lower limb muscle weakness (HP:0009053)3.23619176
38Muscle hypertrophy of the lower extremities (HP:0008968)3.23085001
39Dilated cardiomyopathy (HP:0001644)3.18962204
40Subaortic stenosis (HP:0001682)3.16897189
41Abnormality of the left ventricular outflow tract (HP:0011103)3.16897189
42Alopecia of scalp (HP:0002293)3.12064937
43Oral leukoplakia (HP:0002745)3.04943748
44Congenital ichthyosiform erythroderma (HP:0007431)3.04096877
45* Ventricular arrhythmia (HP:0004308)3.03243043
46* Nail dystrophy (HP:0008404)2.99877042
47* Abnormal blistering of the skin (HP:0008066)2.98862829
48Hamartoma of the eye (HP:0010568)2.95589504
49Abnormal hair laboratory examination (HP:0003328)2.95002746
50Bundle branch block (HP:0011710)2.83260492
51Erythema (HP:0010783)2.82994196
52Prolonged QT interval (HP:0001657)2.69666818
53Myoglobinuria (HP:0002913)2.65163726
54Ridged nail (HP:0001807)2.64223047
55Parakeratosis (HP:0001036)2.63890947
56* Sparse eyelashes (HP:0000653)2.60842180
57Abnormal atrioventricular conduction (HP:0005150)2.58859779
58Erythroderma (HP:0001019)2.58578810
59Aplasia cutis congenita (HP:0001057)2.54673871
60Abnormality of the labia majora (HP:0012881)2.53923661
61Curly hair (HP:0002212)2.51845952
62Atrioventricular block (HP:0001678)2.49349214
63EMG: myopathic abnormalities (HP:0003458)2.48674722
64Heart block (HP:0012722)2.46621697
65Septate vagina (HP:0001153)2.44403211
66Abnormality of the dental root (HP:0006486)2.44109927
67Taurodontia (HP:0000679)2.44109927
68Abnormality of permanent molar morphology (HP:0011071)2.44109927
69Blepharitis (HP:0000498)2.42804444
70Selective tooth agenesis (HP:0001592)2.42229013
71Absent hair (HP:0002298)2.39614894
72Difficulty running (HP:0009046)2.38425201
73Abnormality of molar (HP:0011077)2.37075203
74Abnormality of molar morphology (HP:0011070)2.37075203
75Sparse scalp hair (HP:0002209)2.36652580
76Skin pits (HP:0100276)2.35772120
77Acanthosis nigricans (HP:0000956)2.27897934
78Abnormality of the salivary glands (HP:0010286)2.24778298
79Flat acetabular roof (HP:0003180)2.23734393
80Fragile skin (HP:0001030)2.22335448
81Abnormality of the dental pulp (HP:0006479)2.17180227
82Oligodontia (HP:0000677)2.16814605
83Follicular hyperkeratosis (HP:0007502)2.16491234
84Mildly elevated creatine phosphokinase (HP:0008180)2.15904398
85Vascular calcification (HP:0004934)2.15426377
86Asymmetric septal hypertrophy (HP:0001670)2.13999144
87Areflexia of lower limbs (HP:0002522)2.12773905
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10111126
89Difficulty climbing stairs (HP:0003551)2.09310111
90Cardiovascular calcification (HP:0011915)2.07861594
91Congenital malformation of the right heart (HP:0011723)2.06359703
92Double outlet right ventricle (HP:0001719)2.06359703
93Deep venous thrombosis (HP:0002625)2.05940071
94Fatigable weakness (HP:0003473)2.05181479
95Abnormality of the neuromuscular junction (HP:0003398)2.05181479
96Ectropion (HP:0000656)2.04943155
97Abnormality of the nasal septum (HP:0000419)2.04458971
98Congenital, generalized hypertrichosis (HP:0004540)2.03360970
99Ankyloglossia (HP:0010296)2.01887708
100Nasolacrimal duct obstruction (HP:0000579)2.01467240
101Abnormality of the lacrimal duct (HP:0011481)1.99526789
102Neck muscle weakness (HP:0000467)1.98713686
103* Ventricular fibrillation (HP:0001663)1.97718188
104Dry hair (HP:0011359)1.96748659
105Rhabdomyolysis (HP:0003201)1.94702958
106* Sudden cardiac death (HP:0001645)1.91205020
107Scapular winging (HP:0003691)1.90574851
108Hypoplasia of dental enamel (HP:0006297)1.87535905
109Corneal erosion (HP:0200020)1.87132472
110Distal lower limb amyotrophy (HP:0008944)1.86323099
111Type 1 muscle fiber predominance (HP:0003803)1.86264476
112Hypoplastic labia majora (HP:0000059)1.83351797
113Hypoglycemic coma (HP:0001325)1.80202460
114Carious teeth (HP:0000670)1.78697608
115Preauricular pit (HP:0004467)1.78467888
116Periauricular skin pits (HP:0100277)1.78467888
117Laryngomalacia (HP:0001601)1.77832639
118Labial hypoplasia (HP:0000066)1.75945395
119Rectal prolapse (HP:0002035)1.75574808
120* Advanced eruption of teeth (HP:0006288)1.75278268
121Abnormality of the nasolacrimal system (HP:0000614)1.75254356
122Abnormal EKG (HP:0003115)1.74587070
123Pterygium (HP:0001059)1.73329347
124Hypohidrosis (HP:0000966)1.69959743
125Myotonia (HP:0002486)1.68603875
126Asymmetry of the thorax (HP:0001555)1.67101406
127Hypodontia (HP:0000668)1.65604079
128Pruritus (HP:0000989)1.65107132
129Melanocytic nevus (HP:0000995)1.64440411
130Aplasia involving bones of the upper limbs (HP:0009823)1.63965062
131Aplasia of the phalanges of the hand (HP:0009802)1.63965062
132Aplasia involving bones of the extremities (HP:0009825)1.63965062
133Popliteal pterygium (HP:0009756)1.63039442
134Broad metatarsal (HP:0001783)1.63016041
135Malnutrition (HP:0004395)1.62687800
136* Anonychia (HP:0001798)1.62309610
137Limb-girdle muscle atrophy (HP:0003797)1.62074565
138Abnormality of placental membranes (HP:0011409)1.61239830
139Amniotic constriction ring (HP:0009775)1.61239830
140Dehydration (HP:0001944)1.58537463
141Hyperhidrosis (HP:0000975)1.58452218
142Neonatal short-limb short stature (HP:0008921)1.56918011
143Abnormality of carpal bone ossification (HP:0006257)1.56196506
144Hypoplastic female external genitalia (HP:0012815)1.55791020
145Coarse hair (HP:0002208)1.55188448
146Brittle hair (HP:0002299)1.54329726
147Intrahepatic cholestasis (HP:0001406)1.52530568
148Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.51783992
149Premature rupture of membranes (HP:0001788)1.51414523
150Mitral stenosis (HP:0001718)1.50472363
151Depressed nasal tip (HP:0000437)1.49739891
152Autoamputation (HP:0001218)1.49296794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.11838915
2LMTK23.29144076
3MAPKAPK32.89646069
4MST1R2.85192166
5LATS12.79235713
6OBSCN2.77249244
7MAP3K32.75586236
8FER2.64542930
9DMPK2.60070923
10CDK122.50176521
11TRIB32.44930059
12PKN22.44135284
13MYLK2.31807395
14STK242.26981501
15EPHB22.20859582
16EPHA22.03911278
17MST41.98298070
18PHKG11.81209080
19PHKG21.81209080
20PIK3CA1.78686968
21PDK31.75334744
22PDK41.75334744
23TRPM71.73228101
24RPS6KB21.68920083
25RIPK11.66381802
26PTK61.57935869
27ERN11.53499763
28ICK1.50873001
29MAP3K21.48096616
30MAP3K61.47522760
31STK391.44652202
32STK38L1.41320963
33TIE11.40724169
34AKT31.38923810
35MET1.27466092
36EPHB11.22385185
37PRKD11.20164248
38MAP3K71.19660866
39FGFR41.18165653
40MAP3K91.17840417
41PAK31.15660545
42PDK21.09699693
43FGFR21.08204984
44BCKDK1.06852527
45PDGFRA1.03894331
46EPHA31.03728489
47NEK11.00427391
48WNK10.98283655
49FRK0.98136298
50EEF2K0.96406010
51LRRK20.96040954
52CDC42BPA0.95839235
53ROCK10.93063140
54MAP3K120.92703247
55SMG10.91063729
56SIK10.89563966
57FGFR10.86809879
58ILK0.83853680
59PBK0.81697840
60RET0.81571301
61TAOK10.77904381
62PAK40.77842194
63FGFR30.77410419
64BCR0.76948753
65TGFBR20.76189079
66MAP3K10.75402182
67INSRR0.75227593
68PTK20.74018163
69GRK70.73050641
70NEK60.72574530
71CAMK2D0.72558704
72CAMK1G0.71521854
73MAP3K50.70685181
74SCYL20.70548938
75MAP2K20.68303794
76STK100.67265152
77SGK2230.65119949
78SGK4940.65119949
79LATS20.64755223
80RPS6KB10.64507731
81MAP2K30.64430546
82STK30.64021984
83NTRK10.62896494
84MAPKAPK20.62841989
85WNK40.62257304
86PRKAA20.61212280
87CAMK1D0.60990522
88BRD40.60747183
89ZAK0.58936807
90PIK3CG0.57312424
91ERBB20.56007426
92SGK30.55990069
93DYRK1B0.51902733
94STK40.51829102
95FLT30.51563776
96RPS6KA10.51205722
97MUSK0.49025713
98MTOR0.48286990
99RPS6KL10.47267254
100RPS6KC10.47267254
101MAP2K60.47121599
102MAP3K110.46776194
103PRKCI0.46177586
104CDK60.45358369
105MAP2K10.45208652
106PRKCE0.45205817
107TGFBR10.43573916
108NLK0.42508886
109MAP3K100.42094771
110MAPKAPK50.41397996
111TESK10.41006799
112BRSK20.40339510
113ROCK20.39914969
114RPS6KA20.39433832
115STK380.39072933
116PRKG20.38172144
117CHUK0.37859045
118PRKAA10.37619897
119PDGFRB0.37231789
120MAPK150.36834886
121RPS6KA60.36736923
122PRKD20.36130281
123PIM20.35742400
124CSNK1E0.35699281
125CAMK40.35086523
126NME10.34627560
127GSK3A0.33441693
128DDR20.32698732
129MAPK120.32606075
130CDK70.32605097
131ERBB30.30497010
132BMX0.30496286
133JAK10.29999695
134MELK0.29424702
135PKN10.28698819
136TYK20.28680602
137MAPK110.28175305
138SGK20.27788925
139SGK10.26914380

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.48761650
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.07491480
3Dilated cardiomyopathy_Homo sapiens_hsa054143.02550888
4* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.74910940
5Fatty acid degradation_Homo sapiens_hsa000712.70483116
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.68759993
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61194777
8Cardiac muscle contraction_Homo sapiens_hsa042602.55565197
9Propanoate metabolism_Homo sapiens_hsa006402.03730540
10Fatty acid elongation_Homo sapiens_hsa000621.92922892
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.91099662
12ECM-receptor interaction_Homo sapiens_hsa045121.85185897
13Adherens junction_Homo sapiens_hsa045201.84934099
14Fatty acid metabolism_Homo sapiens_hsa012121.77727744
15Fat digestion and absorption_Homo sapiens_hsa049751.71110356
16Tight junction_Homo sapiens_hsa045301.65618366
17Phenylalanine metabolism_Homo sapiens_hsa003601.65177465
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64611776
19Complement and coagulation cascades_Homo sapiens_hsa046101.62464959
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57283223
21Linoleic acid metabolism_Homo sapiens_hsa005911.52356289
22Vitamin digestion and absorption_Homo sapiens_hsa049771.43841644
23Circadian rhythm_Homo sapiens_hsa047101.40801551
24Basal cell carcinoma_Homo sapiens_hsa052171.39118229
25PPAR signaling pathway_Homo sapiens_hsa033201.38174462
26Carbon metabolism_Homo sapiens_hsa012001.37822221
27Insulin resistance_Homo sapiens_hsa049311.27556812
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27330973
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.24731297
30Viral myocarditis_Homo sapiens_hsa054161.24488230
31Ether lipid metabolism_Homo sapiens_hsa005651.20093283
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19997882
33Focal adhesion_Homo sapiens_hsa045101.18429277
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16042682
35Caffeine metabolism_Homo sapiens_hsa002321.12475760
36Tryptophan metabolism_Homo sapiens_hsa003801.11058741
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11049775
38Ovarian steroidogenesis_Homo sapiens_hsa049131.10481220
39Proteoglycans in cancer_Homo sapiens_hsa052051.09986015
40Amoebiasis_Homo sapiens_hsa051461.08620937
41Steroid biosynthesis_Homo sapiens_hsa001001.07267678
42Starch and sucrose metabolism_Homo sapiens_hsa005001.07058262
43beta-Alanine metabolism_Homo sapiens_hsa004101.06858376
44Hippo signaling pathway_Homo sapiens_hsa043901.05803343
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01275893
46Butanoate metabolism_Homo sapiens_hsa006500.97212115
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96489761
48Histidine metabolism_Homo sapiens_hsa003400.96176562
49Arachidonic acid metabolism_Homo sapiens_hsa005900.94730110
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.93368100
51Lysine degradation_Homo sapiens_hsa003100.93085209
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92396948
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.91443546
54Alzheimers disease_Homo sapiens_hsa050100.89119555
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86749428
56Oxidative phosphorylation_Homo sapiens_hsa001900.85907493
57Tyrosine metabolism_Homo sapiens_hsa003500.85737521
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85686921
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85238483
60Pyruvate metabolism_Homo sapiens_hsa006200.84915513
61Inositol phosphate metabolism_Homo sapiens_hsa005620.84353193
62Small cell lung cancer_Homo sapiens_hsa052220.83962855
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82038852
64Arginine biosynthesis_Homo sapiens_hsa002200.81160678
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.80174086
66Protein digestion and absorption_Homo sapiens_hsa049740.79342850
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79336461
68Thyroid hormone synthesis_Homo sapiens_hsa049180.78409972
69Sulfur metabolism_Homo sapiens_hsa009200.78238389
70Parkinsons disease_Homo sapiens_hsa050120.77913489
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76508242
72Bladder cancer_Homo sapiens_hsa052190.74854802
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74737432
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.74389643
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72403264
76Sphingolipid metabolism_Homo sapiens_hsa006000.71260700
77Arginine and proline metabolism_Homo sapiens_hsa003300.71160309
78Toxoplasmosis_Homo sapiens_hsa051450.70387760
79Chemical carcinogenesis_Homo sapiens_hsa052040.70346515
80Glucagon signaling pathway_Homo sapiens_hsa049220.70330458
81Choline metabolism in cancer_Homo sapiens_hsa052310.69342654
82Pancreatic secretion_Homo sapiens_hsa049720.68619186
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68325755
84Mineral absorption_Homo sapiens_hsa049780.68204983
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.67699566
86Melanogenesis_Homo sapiens_hsa049160.65935956
87ABC transporters_Homo sapiens_hsa020100.65738052
88mTOR signaling pathway_Homo sapiens_hsa041500.65584393
89Insulin signaling pathway_Homo sapiens_hsa049100.65194413
90VEGF signaling pathway_Homo sapiens_hsa043700.64658430
91Fructose and mannose metabolism_Homo sapiens_hsa000510.64605220
92Retinol metabolism_Homo sapiens_hsa008300.64603976
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62816548
94Hedgehog signaling pathway_Homo sapiens_hsa043400.62702238
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61807216
96Thyroid cancer_Homo sapiens_hsa052160.61806768
97N-Glycan biosynthesis_Homo sapiens_hsa005100.61643047
98Prostate cancer_Homo sapiens_hsa052150.61495708
99Dorso-ventral axis formation_Homo sapiens_hsa043200.61486344
100Vibrio cholerae infection_Homo sapiens_hsa051100.60894585
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59258838
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59196954
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59091250
104Fatty acid biosynthesis_Homo sapiens_hsa000610.57845188
105Vitamin B6 metabolism_Homo sapiens_hsa007500.57770427
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55399268
107AMPK signaling pathway_Homo sapiens_hsa041520.54017287
108Renin-angiotensin system_Homo sapiens_hsa046140.53923944
109Bile secretion_Homo sapiens_hsa049760.52763776
110Renal cell carcinoma_Homo sapiens_hsa052110.52601359
111Other glycan degradation_Homo sapiens_hsa005110.52530387
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52243493
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.52017433
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51549312
115Notch signaling pathway_Homo sapiens_hsa043300.49890453
116Endometrial cancer_Homo sapiens_hsa052130.49810965
117GnRH signaling pathway_Homo sapiens_hsa049120.48821023
118Gastric acid secretion_Homo sapiens_hsa049710.47908406
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47166700
120MicroRNAs in cancer_Homo sapiens_hsa052060.46353591
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44859387
122Renin secretion_Homo sapiens_hsa049240.44003858
123HIF-1 signaling pathway_Homo sapiens_hsa040660.43468048
124Axon guidance_Homo sapiens_hsa043600.42962406
125TGF-beta signaling pathway_Homo sapiens_hsa043500.40799110
126Galactose metabolism_Homo sapiens_hsa000520.39572700
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38753260
128Type II diabetes mellitus_Homo sapiens_hsa049300.36696439
129Pathways in cancer_Homo sapiens_hsa052000.36139308
130Biosynthesis of amino acids_Homo sapiens_hsa012300.34133787
131Wnt signaling pathway_Homo sapiens_hsa043100.33584964
132Platelet activation_Homo sapiens_hsa046110.32717388
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32676830
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32591902

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