DSPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein-chromophore linkage (GO:0018298)9.03853914
2gamma-aminobutyric acid transport (GO:0015812)7.06765275
3sperm capacitation (GO:0048240)6.77641502
4multicellular organism reproduction (GO:0032504)6.24415947
5cilium or flagellum-dependent cell motility (GO:0001539)6.08885507
6detection of light stimulus involved in sensory perception (GO:0050962)5.90629506
7detection of light stimulus involved in visual perception (GO:0050908)5.90629506
8protein K11-linked deubiquitination (GO:0035871)5.81776639
9establishment of protein localization to Golgi (GO:0072600)5.30054341
10sperm motility (GO:0030317)5.16959460
11positive regulation of inositol phosphate biosynthetic process (GO:0060732)5.13385986
12tachykinin receptor signaling pathway (GO:0007217)4.76750448
13dendritic spine morphogenesis (GO:0060997)4.61561742
14protein targeting to Golgi (GO:0000042)4.43418801
15protein K48-linked deubiquitination (GO:0071108)4.34786474
16rhodopsin mediated signaling pathway (GO:0016056)4.34452919
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.32578330
18membrane depolarization during action potential (GO:0086010)4.30772318
19vocalization behavior (GO:0071625)4.23288505
20postsynaptic membrane organization (GO:0001941)4.22917143
21reproduction (GO:0000003)4.18124071
22response to pheromone (GO:0019236)4.16407175
23protein K63-linked deubiquitination (GO:0070536)4.09484495
24neuron cell-cell adhesion (GO:0007158)4.07766962
25regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06787406
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.04856883
27retrograde transport, vesicle recycling within Golgi (GO:0000301)4.03119096
28regulation of inositol phosphate biosynthetic process (GO:0010919)3.99011464
29calcium ion import (GO:0070509)3.94580492
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.92971611
31positive regulation of hair follicle development (GO:0051798)3.74857094
32positive regulation of hair cycle (GO:0042635)3.74857094
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71292724
34Peyers patch development (GO:0048541)3.70802131
35mucosal-associated lymphoid tissue development (GO:0048537)3.70802131
36inner ear receptor cell development (GO:0060119)3.69522831
37righting reflex (GO:0060013)3.65501969
38locomotory exploration behavior (GO:0035641)3.64615859
39regulation of interleukin-5 production (GO:0032674)3.57476282
40neuronal ion channel clustering (GO:0045161)3.54619295
41post-embryonic morphogenesis (GO:0009886)3.54604976
42cell proliferation in forebrain (GO:0021846)3.52585358
43activated T cell proliferation (GO:0050798)3.51935649
44positive regulation of cAMP-mediated signaling (GO:0043950)3.51516987
45phosphatidylinositol acyl-chain remodeling (GO:0036149)3.49851227
46thyroid hormone metabolic process (GO:0042403)3.49839387
47seminiferous tubule development (GO:0072520)3.47430304
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.45926160
49import into cell (GO:0098657)3.45450206
50proline transport (GO:0015824)3.44674910
51phosphatidylserine acyl-chain remodeling (GO:0036150)3.41895459
52serotonin receptor signaling pathway (GO:0007210)3.39147386
53regulation of glutamate receptor signaling pathway (GO:1900449)3.37642692
54axonal fasciculation (GO:0007413)3.32693981
55protein localization to Golgi apparatus (GO:0034067)3.30840732
56central nervous system projection neuron axonogenesis (GO:0021952)3.28979964
57cilium movement (GO:0003341)3.28842919
58sulfation (GO:0051923)3.28724571
59tryptophan catabolic process (GO:0006569)3.25920921
60indole-containing compound catabolic process (GO:0042436)3.25920921
61indolalkylamine catabolic process (GO:0046218)3.25920921
62positive regulation of osteoblast proliferation (GO:0033690)3.25343234
63single fertilization (GO:0007338)3.24873290
64epithelial cilium movement (GO:0003351)3.22979075
65regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.22285502
66histone H3-K36 demethylation (GO:0070544)3.14689955
67cell morphogenesis involved in neuron differentiation (GO:0048667)3.14273854
68negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.13660268
69positive regulation of uterine smooth muscle contraction (GO:0070474)3.13022984
70regulation of female gonad development (GO:2000194)3.12547581
71cerebral cortex neuron differentiation (GO:0021895)3.12299277
72positive regulation of synapse assembly (GO:0051965)3.09832343
73short-term memory (GO:0007614)3.08754999
74nerve growth factor signaling pathway (GO:0038180)3.08142641
75reflex (GO:0060004)3.07950302
76negative regulation of T cell mediated immunity (GO:0002710)3.07243243
77regulation of establishment of cell polarity (GO:2000114)3.05173462
78regulation of appetite (GO:0032098)3.03435185
79lymphangiogenesis (GO:0001946)3.02953726
80cellular ketone body metabolic process (GO:0046950)3.02873912
81motile cilium assembly (GO:0044458)3.02318289
82detection of mechanical stimulus involved in sensory perception (GO:0050974)3.02223235
83neuron recognition (GO:0008038)3.01115546
84mating behavior (GO:0007617)2.99864950
85head development (GO:0060322)2.97258428
86nephron tubule morphogenesis (GO:0072078)2.96804323
87nephron epithelium morphogenesis (GO:0072088)2.96804323
88photoreceptor cell maintenance (GO:0045494)2.94582509
89positive regulation of vasculogenesis (GO:2001214)2.93961674
90positive regulation of male gonad development (GO:2000020)2.92199274
91negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.90862586
92regulation of G0 to G1 transition (GO:0070316)2.90683952
93layer formation in cerebral cortex (GO:0021819)2.90627184
94axonemal dynein complex assembly (GO:0070286)2.90615972
95maintenance of gastrointestinal epithelium (GO:0030277)2.89035666
96prepulse inhibition (GO:0060134)2.88649102
97phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.87633259
98synaptic vesicle maturation (GO:0016188)2.85985126
99cerebral cortex radially oriented cell migration (GO:0021799)2.85541451
100adenosine metabolic process (GO:0046085)2.79597229
101negative regulation of calcium ion transport into cytosol (GO:0010523)2.78647620
102striated muscle atrophy (GO:0014891)2.77950207
103negative regulation by host of viral transcription (GO:0043922)2.77357059
104regulation of gonadotropin secretion (GO:0032276)2.75443367
105exploration behavior (GO:0035640)2.74543175
106transmission of nerve impulse (GO:0019226)2.73536686
107chemosensory behavior (GO:0007635)2.73477920
108glycerophospholipid catabolic process (GO:0046475)2.72842539
109neurotransmitter catabolic process (GO:0042135)2.72829935
110neuronal action potential (GO:0019228)2.72776873
111phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71129692
112detection of light stimulus (GO:0009583)2.70234353
113negative regulation of interleukin-8 production (GO:0032717)2.69902665
114calcium-mediated signaling using intracellular calcium source (GO:0035584)2.69469865
115primary amino compound metabolic process (GO:1901160)2.68456811
116regulation of integrin-mediated signaling pathway (GO:2001044)2.68285232
117regulation of synapse assembly (GO:0051963)2.67279233
118G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66832326
119sensory perception of smell (GO:0007608)2.66009938
120regulation of cAMP-dependent protein kinase activity (GO:2000479)2.65796850
121regulation of establishment or maintenance of cell polarity (GO:0032878)2.64293191
122phasic smooth muscle contraction (GO:0014821)2.63990009
123acrosome assembly (GO:0001675)2.63008284
124ketone body metabolic process (GO:1902224)2.61928717
125positive regulation of dendritic spine morphogenesis (GO:0061003)2.61476428
126G-protein coupled receptor internalization (GO:0002031)2.61036434
127DNA double-strand break processing (GO:0000729)2.60973479
128neuronal action potential propagation (GO:0019227)2.60477584
129sperm-egg recognition (GO:0035036)2.59909837
130negative regulation of cardiac muscle hypertrophy (GO:0010614)2.59529836
131negative regulation of neurotransmitter transport (GO:0051589)2.59370151
132positive regulation of CREB transcription factor activity (GO:0032793)2.57657204
133glutamate receptor signaling pathway (GO:0007215)2.57534077
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.56449633
135hematopoietic stem cell proliferation (GO:0071425)2.55928476
136skeletal muscle adaptation (GO:0043501)2.54836420
137regulation of neuronal synaptic plasticity (GO:0048168)2.54702960
138behavioral response to nicotine (GO:0035095)2.54680477
139limb bud formation (GO:0060174)2.53999947
140regulation of hair follicle development (GO:0051797)2.53804913
141glucocorticoid biosynthetic process (GO:0006704)2.53473233
142angiogenesis involved in wound healing (GO:0060055)2.53415644
143positive regulation of neurotransmitter secretion (GO:0001956)2.53098866
144regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52684544
145regulation of cAMP-mediated signaling (GO:0043949)2.52171558
146regulation of uterine smooth muscle contraction (GO:0070472)2.50532354
147axoneme assembly (GO:0035082)2.50081977
148negative regulation of protein localization to cell surface (GO:2000009)2.49821320
149flavonoid metabolic process (GO:0009812)2.49761918
150plasma membrane repair (GO:0001778)2.48962074
151mast cell degranulation (GO:0043303)2.48889348
152mast cell activation involved in immune response (GO:0002279)2.48889348
153G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48113108
154regulation of voltage-gated calcium channel activity (GO:1901385)2.47797380
155interkinetic nuclear migration (GO:0022027)2.47076469
156cornea development in camera-type eye (GO:0061303)2.45049985
157lateral ventricle development (GO:0021670)2.44243838
158auditory behavior (GO:0031223)2.41928699
159glutamate secretion (GO:0014047)2.40806995
160neuromuscular process controlling posture (GO:0050884)2.40782551
161dendritic spine organization (GO:0097061)2.40599084
162negative regulation of organelle assembly (GO:1902116)2.40469511
163ionotropic glutamate receptor signaling pathway (GO:0035235)2.39705414
164behavioral response to ethanol (GO:0048149)2.39668885
165cranial nerve morphogenesis (GO:0021602)2.39614324
166regulation of postsynaptic membrane potential (GO:0060078)2.37297941
167neurotransmitter secretion (GO:0007269)2.36028532
168positive regulation of vascular permeability (GO:0043117)2.35991486
169glycoprotein biosynthetic process (GO:0009101)2.35948428
170synaptic vesicle exocytosis (GO:0016079)2.35859823
171dendrite morphogenesis (GO:0048813)2.33576571
172positive regulation of fibroblast migration (GO:0010763)2.33517372
173startle response (GO:0001964)2.31908630
174regulation of long-term neuronal synaptic plasticity (GO:0048169)2.31904150
175positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.31618248
176auditory receptor cell differentiation (GO:0042491)2.31258338
177ovulation cycle (GO:0042698)2.30250603
178cerebellar Purkinje cell differentiation (GO:0021702)2.30140229
179negative regulation of muscle hypertrophy (GO:0014741)2.28262718
180central nervous system neuron axonogenesis (GO:0021955)2.27792702
181protein localization to synapse (GO:0035418)2.25488918
182neurotransmitter transport (GO:0006836)2.25142062
183left/right axis specification (GO:0070986)2.24671971
184glycine transport (GO:0015816)2.24474926
185positive regulation of membrane potential (GO:0045838)2.24365357
186cell migration in hindbrain (GO:0021535)2.24305144
187positive regulation of dendritic spine development (GO:0060999)2.23665654
188inner ear receptor stereocilium organization (GO:0060122)2.22731437
189regulation of vesicle fusion (GO:0031338)2.22428419
190regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.20971680
191gamma-aminobutyric acid signaling pathway (GO:0007214)2.20759451
192DNA integration (GO:0015074)2.20074955
193hydrogen peroxide biosynthetic process (GO:0050665)2.18488600
194L-amino acid import (GO:0043092)2.18246474
195response to auditory stimulus (GO:0010996)2.16921651
196phospholipid scrambling (GO:0017121)2.16130835
197regulation of synapse organization (GO:0050807)2.15410361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.12009137
2GBX2_23144817_ChIP-Seq_PC3_Human3.03435840
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.92599614
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64610037
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57297559
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51925626
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.45111029
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36113257
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35686196
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28953021
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28953021
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28215943
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27822213
14DROSHA_22980978_ChIP-Seq_HELA_Human2.19084828
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15086732
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13460945
17ER_23166858_ChIP-Seq_MCF-7_Human2.11103827
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.05298993
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03919460
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.01983473
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95995017
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95211670
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.93441582
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93260140
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92834208
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92558361
27VDR_22108803_ChIP-Seq_LS180_Human1.86383958
28AR_21572438_ChIP-Seq_LNCaP_Human1.80269052
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.73919920
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.73182385
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70369119
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66996855
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61532450
34* AR_25329375_ChIP-Seq_VCAP_Human1.59083247
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58406980
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.56301311
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53550724
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53485909
39BCAT_22108803_ChIP-Seq_LS180_Human1.52036252
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51416456
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50159560
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46772304
43CBP_20019798_ChIP-Seq_JUKART_Human1.46609919
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46609919
45SMAD4_21799915_ChIP-Seq_A2780_Human1.46254820
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45674539
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44739842
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.43225602
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43132318
50TP53_18474530_ChIP-ChIP_U2OS_Human1.40986112
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40612112
52TAF15_26573619_Chip-Seq_HEK293_Human1.40516847
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39315068
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38944147
55TCF4_23295773_ChIP-Seq_U87_Human1.38793351
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38267549
57P300_19829295_ChIP-Seq_ESCs_Human1.37584562
58* RUNX2_22187159_ChIP-Seq_PCA_Human1.37263499
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36640522
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36170157
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34241044
62EWS_26573619_Chip-Seq_HEK293_Human1.32919424
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.32129736
64REST_21632747_ChIP-Seq_MESCs_Mouse1.30927325
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30645180
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30036660
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28465151
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28168346
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.27502119
70FUS_26573619_Chip-Seq_HEK293_Human1.27001591
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26075900
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25445181
73GATA1_22025678_ChIP-Seq_K562_Human1.25421576
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24899754
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24207076
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23579526
77KDM2B_26808549_Chip-Seq_REH_Human1.23076880
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21661455
79* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21224450
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21196470
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20925097
82ETV1_20927104_ChIP-Seq_GIST48_Human1.20708305
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.20558124
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20309793
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20309793
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.18383792
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17949310
88RNF2_27304074_Chip-Seq_NSC_Mouse1.17125707
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.17103846
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.15957392
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13860371
92AHR_22903824_ChIP-Seq_MCF-7_Human1.13409182
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11441260
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10697217
95TBL1_22424771_ChIP-Seq_293T_Human1.09515042
96SMAD4_21741376_ChIP-Seq_HESCs_Human1.09425310
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09245641
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.09218520
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.08811651
100RBPJ_21746931_ChIP-Seq_IB4_Human1.08614388
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.08547916
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.08501995
103OCT1_27270436_Chip-Seq_PROSTATE_Human1.08059225
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.07899153
105CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07216821
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06950740
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.06488595
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.06345854
109RXR_22108803_ChIP-Seq_LS180_Human1.06260354
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.05927805
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05559744
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05202269
113NFYB_21822215_ChIP-Seq_K562_Human1.04943861
114AR_20517297_ChIP-Seq_VCAP_Human1.04735279
115TCF4_22108803_ChIP-Seq_LS180_Human1.04691513
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.04590783
117PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03595349
118P53_22387025_ChIP-Seq_ESCs_Mouse1.03492349
119LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03285188
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02568220
121PHF8_20622853_ChIP-Seq_HELA_Human1.02042020
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.01866428
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01760992
124ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01272448
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01048111
126* AR_19668381_ChIP-Seq_PC3_Human1.00464329
127IGF1R_20145208_ChIP-Seq_DFB_Human1.00388488
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99190377
129* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99176485
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.98988564
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98896891
132* CJUN_26792858_Chip-Seq_BT549_Human0.98814147
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98700525
134HNFA_21074721_ChIP-Seq_CACO-2_Human0.98345289
135NMYC_18555785_Chip-Seq_ESCs_Mouse0.98198415
136P300_18555785_Chip-Seq_ESCs_Mouse0.97419451
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97416670
138ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97067491
139TP53_16413492_ChIP-PET_HCT116_Human0.96915485
140* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96555075
141* FOXA1_25329375_ChIP-Seq_VCAP_Human0.96555075
142CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96205544
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.96204376
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95394976
145STAT3_23295773_ChIP-Seq_U87_Human0.95209939
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94727295
147ZNF274_21170338_ChIP-Seq_K562_Hela0.94062331
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93610590
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93166525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex7.21942556
2MP0005503_abnormal_tendon_morphology4.29715612
3MP0004859_abnormal_synaptic_plasticity3.97621150
4MP0003646_muscle_fatigue3.30591382
5MP0003183_abnormal_peptide_metabolism3.25946780
6MP0003880_abnormal_central_pattern3.24745051
7MP0004043_abnormal_pH_regulation3.12919898
8MP0001486_abnormal_startle_reflex3.04246981
9MP0003878_abnormal_ear_physiology3.01060492
10MP0005377_hearing/vestibular/ear_phenot3.01060492
11MP0003136_yellow_coat_color2.89985784
12MP0001501_abnormal_sleep_pattern2.84786166
13MP0005623_abnormal_meninges_morphology2.76212677
14MP0009046_muscle_twitch2.60929751
15MP0005451_abnormal_body_composition2.59777483
16MP0003635_abnormal_synaptic_transmissio2.50870850
17MP0008057_abnormal_DNA_replication2.36748168
18MP0005410_abnormal_fertilization2.32312026
19MP0009745_abnormal_behavioral_response2.30721173
20MP0005257_abnormal_intraocular_pressure2.30051171
21MP0002138_abnormal_hepatobiliary_system2.26438941
22MP0002254_reproductive_system_inflammat2.24824978
23MP0000372_irregular_coat_pigmentation2.24039198
24MP0004742_abnormal_vestibular_system2.22129513
25MP0002277_abnormal_respiratory_mucosa2.19505359
26MP0003705_abnormal_hypodermis_morpholog2.19265712
27MP0001188_hyperpigmentation2.17088918
28MP0000383_abnormal_hair_follicle2.12155616
29MP0005310_abnormal_salivary_gland2.01036348
30MP0004270_analgesia2.00871859
31MP0010678_abnormal_skin_adnexa1.95695561
32MP0002572_abnormal_emotion/affect_behav1.95326263
33MP0008004_abnormal_stomach_pH1.90425936
34MP0002102_abnormal_ear_morphology1.89397375
35MP0000579_abnormal_nail_morphology1.89087298
36MP0006276_abnormal_autonomic_nervous1.88612408
37MP0008875_abnormal_xenobiotic_pharmacok1.87344035
38MP0001984_abnormal_olfaction1.84513618
39MP0002272_abnormal_nervous_system1.81305637
40MP0005670_abnormal_white_adipose1.80909262
41MP0002064_seizures1.76060916
42MP0001502_abnormal_circadian_rhythm1.75278020
43MP0002063_abnormal_learning/memory/cond1.73617131
44MP0006072_abnormal_retinal_apoptosis1.73444452
45MP0004142_abnormal_muscle_tone1.73319381
46MP0004272_abnormal_basement_membrane1.66309006
47MP0003866_abnormal_defecation1.65206812
48MP0005253_abnormal_eye_physiology1.61256618
49MP0000427_abnormal_hair_cycle1.60961211
50MP0001764_abnormal_homeostasis1.58924534
51MP0000778_abnormal_nervous_system1.55287459
52MP0004381_abnormal_hair_follicle1.53431390
53MP0002837_dystrophic_cardiac_calcinosis1.52680671
54MP0002067_abnormal_sensory_capabilities1.52105627
55MP0003690_abnormal_glial_cell1.50203782
56MP0009250_abnormal_appendicular_skeleto1.49125621
57MP0005645_abnormal_hypothalamus_physiol1.48397371
58MP0001542_abnormal_bone_strength1.44342805
59MP0003879_abnormal_hair_cell1.44184891
60MP0004185_abnormal_adipocyte_glucose1.41813902
61MP0002557_abnormal_social/conspecific_i1.41316044
62MP0002184_abnormal_innervation1.40593072
63MP0001485_abnormal_pinna_reflex1.39078953
64MP0002653_abnormal_ependyma_morphology1.37174450
65MP0004147_increased_porphyrin_level1.32842611
66MP0002139_abnormal_hepatobiliary_system1.30970706
67MP0005275_abnormal_skin_tensile1.29332004
68MP0005379_endocrine/exocrine_gland_phen1.28765391
69MP0010234_abnormal_vibrissa_follicle1.26250797
70MP0002822_catalepsy1.25563992
71MP0002736_abnormal_nociception_after1.25535343
72MP0002734_abnormal_mechanical_nocicepti1.21868208
73MP0002233_abnormal_nose_morphology1.21741607
74MP0010329_abnormal_lipoprotein_level1.21283688
75MP0001873_stomach_inflammation1.21269328
76MP0003937_abnormal_limbs/digits/tail_de1.21020742
77MP0002249_abnormal_larynx_morphology1.20722679
78MP0005508_abnormal_skeleton_morphology1.19360952
79MP0004019_abnormal_vitamin_homeostasis1.19121282
80MP0001968_abnormal_touch/_nociception1.18940315
81MP0005464_abnormal_platelet_physiology1.17582740
82MP0001970_abnormal_pain_threshold1.16925572
83MP0003698_abnormal_male_reproductive1.16475112
84MP0008995_early_reproductive_senescence1.15344395
85MP0005647_abnormal_sex_gland1.15001937
86MP0005646_abnormal_pituitary_gland1.14618580
87MP0000955_abnormal_spinal_cord1.13402650
88MP0003011_delayed_dark_adaptation1.11633409
89MP0003806_abnormal_nucleotide_metabolis1.10655504
90MP0004885_abnormal_endolymph1.10338787
91MP0003315_abnormal_perineum_morphology1.10154662
92MP0002108_abnormal_muscle_morphology1.08649795
93MP0001919_abnormal_reproductive_system1.08331999
94MP0005167_abnormal_blood-brain_barrier1.07289157
95MP0005389_reproductive_system_phenotype1.06468852
96MP0008438_abnormal_cutaneous_collagen1.05373734
97MP0001963_abnormal_hearing_physiology1.05180351
98MP0000230_abnormal_systemic_arterial1.04293049
99MP0005187_abnormal_penis_morphology1.04207454
100MP0005671_abnormal_response_to1.02941423
101MP0000371_diluted_coat_color1.02898179
102MP0000647_abnormal_sebaceous_gland1.02655649
103MP0003191_abnormal_cellular_cholesterol1.02560388
104MP0000465_gastrointestinal_hemorrhage1.02013221
105MP0003091_abnormal_cell_migration1.01760252
106MP0003938_abnormal_ear_development1.00905303
107MP0003195_calcinosis1.00694780
108MP0000026_abnormal_inner_ear0.99109929
109MP0001177_atelectasis0.98002416
110MP0002882_abnormal_neuron_morphology0.97343278
111MP0003638_abnormal_response/metabolism_0.96844581
112MP0000569_abnormal_digit_pigmentation0.96617931
113MP0003950_abnormal_plasma_membrane0.95534692
114MP0003045_fibrosis0.93005224
115MP0001929_abnormal_gametogenesis0.90264463
116MP0008569_lethality_at_weaning0.90037971
117MP0008872_abnormal_physiological_respon0.89734241
118MP0008961_abnormal_basal_metabolism0.89282375
119MP0004924_abnormal_behavior0.88389653
120MP0005386_behavior/neurological_phenoty0.88389653
121MP0003137_abnormal_impulse_conducting0.87984947
122MP0002752_abnormal_somatic_nervous0.87942804
123MP0002066_abnormal_motor_capabilities/c0.84324147
124MP0001765_abnormal_ion_homeostasis0.83865462
125MP0003633_abnormal_nervous_system0.83197887
126MP0001348_abnormal_lacrimal_gland0.83028923
127MP0005423_abnormal_somatic_nervous0.82577630
128MP0000462_abnormal_digestive_system0.82128791
129MP0005448_abnormal_energy_balance0.81513942
130MP0000639_abnormal_adrenal_gland0.80862854
131MP0001299_abnormal_eye_distance/0.80193594
132MP0000631_abnormal_neuroendocrine_gland0.80111923
133MP0001663_abnormal_digestive_system0.80034123
134MP0001346_abnormal_lacrimal_gland0.79719056
135MP0005595_abnormal_vascular_smooth0.79435631
136MP0000920_abnormal_myelination0.78320527
137MP0002229_neurodegeneration0.78004333
138MP0000762_abnormal_tongue_morphology0.76519349
139MP0004858_abnormal_nervous_system0.76461101
140MP0000163_abnormal_cartilage_morphology0.75930987
141MP0001270_distended_abdomen0.75459848
142MP0003279_aneurysm0.74821967
143MP0002733_abnormal_thermal_nociception0.74263594
144MP0001986_abnormal_taste_sensitivity0.74123195
145MP0002896_abnormal_bone_mineralization0.73885427
146MP0010386_abnormal_urinary_bladder0.72341060
147MP0000534_abnormal_ureter_morphology0.71359519
148MP0001340_abnormal_eyelid_morphology0.70876461
149MP0004085_abnormal_heartbeat0.70137920
150MP0000613_abnormal_salivary_gland0.69298575
151MP0001664_abnormal_digestion0.68668640
152MP0002751_abnormal_autonomic_nervous0.68398432
153MP0000467_abnormal_esophagus_morphology0.66497900
154MP0003724_increased_susceptibility_to0.66414093
155MP0002089_abnormal_postnatal_growth/wei0.66065591
156MP0005551_abnormal_eye_electrophysiolog0.65401246
157MP0005408_hypopigmentation0.65042822
158MP0002735_abnormal_chemical_nociception0.64723244
159MP0005390_skeleton_phenotype0.64357707
160MP0002970_abnormal_white_adipose0.64280225
161MP0000566_synostosis0.64235009
162MP0005195_abnormal_posterior_eye0.63982494
163MP0002998_abnormal_bone_remodeling0.63242375
164MP0004130_abnormal_muscle_cell0.61381496
165MP0003252_abnormal_bile_duct0.59746824

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)8.27820170
2Duplicated collecting system (HP:0000081)7.67574321
3Chromsome breakage (HP:0040012)6.95776541
4Abnormality of the renal collecting system (HP:0004742)6.63810399
5Attenuation of retinal blood vessels (HP:0007843)5.37294943
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.41072628
7Gaze-evoked nystagmus (HP:0000640)4.39531566
8Reticulocytopenia (HP:0001896)4.16218599
9Decreased circulating renin level (HP:0003351)4.13343844
10Absent rod-and cone-mediated responses on ERG (HP:0007688)4.13208665
11Bony spicule pigmentary retinopathy (HP:0007737)4.13047101
12Tubular atrophy (HP:0000092)4.02881417
13Abnormality of pyrimidine metabolism (HP:0004353)3.99127967
14Abnormality of alanine metabolism (HP:0010916)3.97770957
15Hyperalaninemia (HP:0003348)3.97770957
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.97770957
17Abnormal rod and cone electroretinograms (HP:0008323)3.84736159
18Abnormal drinking behavior (HP:0030082)3.81710342
19Polydipsia (HP:0001959)3.81710342
20Duplication of thumb phalanx (HP:0009942)3.77661454
21Congenital sensorineural hearing impairment (HP:0008527)3.75236386
22Abnormality of DNA repair (HP:0003254)3.57435111
23Amelogenesis imperfecta (HP:0000705)3.53134082
24Abnormality of the renal cortex (HP:0011035)3.51575412
25Ureteral duplication (HP:0000073)3.46349395
26Focal motor seizures (HP:0011153)3.46160612
27Upper limb muscle weakness (HP:0003484)3.34625316
28Concave nail (HP:0001598)3.34262946
29Chronic hepatic failure (HP:0100626)3.13489075
30Hyperactive renin-angiotensin system (HP:0000841)3.08574598
31Acanthocytosis (HP:0001927)3.06884067
32Pancreatic cysts (HP:0001737)3.05653102
33Hydroxyprolinuria (HP:0003080)3.01736179
34Abnormality of proline metabolism (HP:0010907)3.01736179
35Febrile seizures (HP:0002373)3.01470610
36Enlarged penis (HP:0000040)2.95435456
37Broad-based gait (HP:0002136)2.80419042
38Focal seizures (HP:0007359)2.76608079
39Tubulointerstitial fibrosis (HP:0005576)2.73471279
40Distal lower limb amyotrophy (HP:0008944)2.73362117
41Abnormal respiratory motile cilium physiology (HP:0012261)2.72572794
42Lower limb amyotrophy (HP:0007210)2.70821431
43Abnormality of the renal medulla (HP:0100957)2.69417455
44Abnormality of midbrain morphology (HP:0002418)2.68021327
45Molar tooth sign on MRI (HP:0002419)2.68021327
46Polyuria (HP:0000103)2.67677526
47Abnormality of chloride homeostasis (HP:0011422)2.67672069
48Abnormality of renin-angiotensin system (HP:0000847)2.67071088
49Arthropathy (HP:0003040)2.66199121
50Hypophosphatemic rickets (HP:0004912)2.65919653
51Nephronophthisis (HP:0000090)2.65792026
52Osteomalacia (HP:0002749)2.59934806
53True hermaphroditism (HP:0010459)2.58509084
54Generalized tonic-clonic seizures (HP:0002069)2.58309348
55Hypokalemic alkalosis (HP:0001949)2.53836626
56Ectopic kidney (HP:0000086)2.53654746
57Turricephaly (HP:0000262)2.51917818
58Hyperaldosteronism (HP:0000859)2.47846273
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.46937114
60Constricted visual fields (HP:0001133)2.46512240
61Progressive cerebellar ataxia (HP:0002073)2.45700953
62Meckel diverticulum (HP:0002245)2.45094513
63Aplasia of the musculature (HP:0100854)2.45058924
64Gonadotropin excess (HP:0000837)2.42813294
65Pancreatic fibrosis (HP:0100732)2.42772152
66Optic neuritis (HP:0100653)2.41210460
67Retrobulbar optic neuritis (HP:0100654)2.41210460
68Aplasia cutis congenita (HP:0001057)2.39742359
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.39432390
70Absent/shortened dynein arms (HP:0200106)2.39432390
71Cystic liver disease (HP:0006706)2.38682838
72Tubulointerstitial abnormality (HP:0001969)2.38604311
73Atonic seizures (HP:0010819)2.37153559
74Absent forearm bone (HP:0003953)2.36278970
75Aplasia involving forearm bones (HP:0009822)2.36278970
76Enlarged epiphyses (HP:0010580)2.34489078
77Hyperlipoproteinemia (HP:0010980)2.32098915
78Distal lower limb muscle weakness (HP:0009053)2.31945265
79Prolonged bleeding time (HP:0003010)2.31843787
80Metaphyseal dysplasia (HP:0100255)2.29255836
81Renovascular hypertension (HP:0100817)2.28538489
82Poikilocytosis (HP:0004447)2.27221288
83Abnormality of the ileum (HP:0001549)2.27206339
84Absence seizures (HP:0002121)2.26869790
85Myokymia (HP:0002411)2.26518827
86Keratoconus (HP:0000563)2.26220359
87Increased corneal curvature (HP:0100692)2.26220359
88Conical tooth (HP:0000698)2.26058646
89Hyperthyroidism (HP:0000836)2.24766990
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24477432
91Abnormal urine output (HP:0012590)2.23884621
92Absent thumb (HP:0009777)2.21220004
93Septo-optic dysplasia (HP:0100842)2.20199554
94Protruding tongue (HP:0010808)2.20072899
95Dyschromatopsia (HP:0007641)2.18483731
96Abnormal ciliary motility (HP:0012262)2.18368423
97Chronic bronchitis (HP:0004469)2.17989701
98Absent speech (HP:0001344)2.17056628
99Absent radius (HP:0003974)2.16790850
100Genetic anticipation (HP:0003743)2.14288201
101Broad metatarsal (HP:0001783)2.13406745
102Abolished electroretinogram (ERG) (HP:0000550)2.11215501
103Xerostomia (HP:0000217)2.09843094
104Facial shape deformation (HP:0011334)2.09645413
105Potter facies (HP:0002009)2.09645413
106Stage 5 chronic kidney disease (HP:0003774)2.09479239
107Atrophic scars (HP:0001075)2.07485048
108Onion bulb formation (HP:0003383)2.07099905
109Abnormality of renal excretion (HP:0011036)2.06794640
110Abnormality of potassium homeostasis (HP:0011042)2.04286358
111Orchitis (HP:0100796)2.03394471
112Abnormality of the parietal bone (HP:0002696)2.00843135
113Pulmonary artery stenosis (HP:0004415)1.99835027
114Clumsiness (HP:0002312)1.99546030
115Abnormality of the sella turcica (HP:0002679)1.97238147
116Hyperventilation (HP:0002883)1.95879527
117Abnormality of the preputium (HP:0100587)1.95424532
118Fair hair (HP:0002286)1.94374934
119Abnormality of salivation (HP:0100755)1.93043776
120Abnormality of incisor morphology (HP:0011063)1.91766305
121Bulbous nose (HP:0000414)1.91485429
122Abnormality of cochlea (HP:0000375)1.90227254
123Renal salt wasting (HP:0000127)1.89967499
124Tracheomalacia (HP:0002779)1.89471101
125Bronchomalacia (HP:0002780)1.89040105
126Portal hypertension (HP:0001409)1.88224449
127Exotropia (HP:0000577)1.87216985
128Supernumerary bones of the axial skeleton (HP:0009144)1.86438492
129Hemiparesis (HP:0001269)1.85233300
130Tibial bowing (HP:0002982)1.85083135
131Excessive salivation (HP:0003781)1.84644117
132Drooling (HP:0002307)1.84644117
133Glomerulonephritis (HP:0000099)1.83998809
134Abnormal respiratory motile cilium morphology (HP:0005938)1.83711810
135Abnormal respiratory epithelium morphology (HP:0012253)1.83711810
136Hypoplastic ischia (HP:0003175)1.82989438
137Small hand (HP:0200055)1.81389936
138Flat occiput (HP:0005469)1.81158354
139Acute hepatic failure (HP:0006554)1.79687685
140Hypoplastic nipples (HP:0002557)1.78810960
141Xanthomatosis (HP:0000991)1.78326445
142Absent eyebrow (HP:0002223)1.78189759
143Tubulointerstitial nephritis (HP:0001970)1.78126288
144Decreased central vision (HP:0007663)1.77881737
145Congenital hepatic fibrosis (HP:0002612)1.77534730
146Widely patent fontanelles and sutures (HP:0004492)1.77018807
147Congenital stationary night blindness (HP:0007642)1.76287074
148Blue irides (HP:0000635)1.72968047
149Status epilepticus (HP:0002133)1.72713399
150Atelectasis (HP:0100750)1.70090867
151Horseshoe kidney (HP:0000085)1.68844304
152Abnormality of the carotid arteries (HP:0005344)1.67750592
153Clubbing of toes (HP:0100760)1.66831912
154Decreased motor nerve conduction velocity (HP:0003431)1.66003094
155Humeroradial synostosis (HP:0003041)1.64073228
156Synostosis involving the elbow (HP:0003938)1.64073228
157Morphological abnormality of the middle ear (HP:0008609)1.62557297
158Inappropriate behavior (HP:0000719)1.62133421
159Dialeptic seizures (HP:0011146)1.61988336
160Abnormality of reticulocytes (HP:0004312)1.58924092
161Poor eye contact (HP:0000817)1.56594904
162Patellar dislocation (HP:0002999)1.53494406
163Cubitus valgus (HP:0002967)1.53407109
164Short thumb (HP:0009778)1.52478684
165Rhinitis (HP:0012384)1.50609541
166Soft skin (HP:0000977)1.50379382
167Generalized hypopigmentation of hair (HP:0011358)1.50133635
168Ulnar claw (HP:0001178)1.48468685
169Protrusio acetabuli (HP:0003179)1.48197766
170Cardiovascular calcification (HP:0011915)1.47319446
171Hyperkalemia (HP:0002153)1.46223424
172Abnormal social behavior (HP:0012433)1.45780746
173Impaired social interactions (HP:0000735)1.45780746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.76140453
2LATS14.04354934
3CAMK1D3.90082760
4NTRK33.36016953
5CAMK1G3.13811445
6SIK23.09266248
7CAMKK22.73429419
8STK162.58747854
9NTRK22.48690314
10CDK122.41475962
11MAP3K92.36060570
12TXK2.34070351
13WNK42.33257725
14STK392.30168061
15MUSK2.29481545
16NEK62.25295454
17EPHB22.25062978
18CASK2.21665897
19SIK12.21450176
20PLK42.12186888
21TNIK2.09810310
22GRK11.95167643
23INSRR1.94090992
24PAK61.86832290
25NLK1.80284864
26EIF2AK21.78836920
27MARK31.75294192
28MARK11.74207809
29NEK21.65664741
30RIPK11.63149655
31WNK11.61464818
32WNK31.57430685
33PDK31.56668172
34PDK41.56668172
35DDR21.55725117
36BLK1.53931218
37PTK2B1.51790593
38DMPK1.41900527
39ACVR1B1.39529646
40DAPK21.34780765
41PIK3CG1.31551895
42MKNK21.29460839
43FGFR21.29356317
44PNCK1.26041776
45ZAK1.23364096
46TLK11.22128662
47CAMKK11.15312172
48PKN11.14751860
49MET1.13944943
50FES1.10737336
51FGR1.10247979
52NUAK11.08871080
53IRAK21.04646053
54EPHA41.04372354
55BMPR1B1.03557615
56MAP3K61.03007192
57KSR10.98462475
58ADRBK20.94857094
59CDC42BPA0.93191527
60PRKCQ0.90838189
61MAPK130.89745946
62PDK20.89517188
63STK380.87203904
64PRKG20.87012014
65MAP2K70.86988585
66NTRK10.85969474
67MAP3K130.85505451
68ITK0.84144636
69OXSR10.83856303
70CDK50.83663566
71PDK10.82628189
72CAMK2A0.81642891
73PHKG20.79949901
74PHKG10.79949901
75UHMK10.78331997
76PRKCG0.78205465
77TAOK30.77932275
78NEK10.77353002
79LMTK20.76609210
80PINK10.75271761
81PIK3CA0.73362146
82LATS20.72302570
83JAK30.72074800
84KIT0.71537156
85MAPK150.71296529
86BTK0.70892528
87CAMK40.69920627
88SGK10.68874910
89CAMK10.67975652
90PDPK10.67842097
91MINK10.67746260
92ERBB20.66940335
93MKNK10.66720312
94SIK30.65764429
95PAK30.62766133
96HIPK20.62614779
97MAP3K40.61137654
98DYRK1A0.61002180
99PDGFRA0.59998319
100SGK20.59906282
101TYRO30.59605395
102TGFBR20.59327921
103KSR20.58793010
104MST1R0.58693803
105TIE10.57284033
106NME10.56301672
107MAP3K20.56061997
108STK110.55854088
109FYN0.55596740
110JAK10.55546931
111INSR0.54967552
112CSNK1A1L0.54641255
113MAP3K70.52775446
114BRD40.52086100
115MAP2K60.51649388
116MAPK100.50824057
117PRKCH0.50511895
118MARK20.50311126
119PRKAA10.49803440
120ERBB30.49764527
121PRKCE0.49667590
122TGFBR10.49502959
123FGFR30.48738474
124MAP2K40.47270107
125ROCK10.46311219
126EPHA30.46043600
127MAPK120.45980172
128EPHB10.45907492
129FGFR10.45529783
130ADRBK10.45430973
131PTK20.45372703
132TEC0.43956853
133FGFR40.43619825
134ROCK20.42649451
135IRAK10.41022083
136BMX0.40600069
137RIPK40.39504651
138IKBKB0.35905176
139HCK0.35320605
140MELK0.34537444
141PRKD30.33738092
142TRPM70.33665635
143SRC0.32709601
144FER0.32146224
145PLK20.30916338
146PRKCB0.30527918
147LCK0.29329714
148LYN0.29159635
149YES10.29070512
150AKT30.28639759
151PASK0.27684447
152PRKG10.27114126
153SGK2230.26954538
154SGK4940.26954538
155MAPKAPK30.26928378
156MAP2K10.25162913
157RPS6KA60.22299698
158CSF1R0.21093852
159PRKCZ0.20702587
160PDGFRB0.19920768
161PRKCA0.19367158

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.45288538
2Nicotine addiction_Homo sapiens_hsa050332.40079450
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93934174
4Morphine addiction_Homo sapiens_hsa050321.90529447
5Taste transduction_Homo sapiens_hsa047421.87168058
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82469150
7Selenocompound metabolism_Homo sapiens_hsa004501.82149984
8Salivary secretion_Homo sapiens_hsa049701.76104979
9beta-Alanine metabolism_Homo sapiens_hsa004101.69292084
10Glutamatergic synapse_Homo sapiens_hsa047241.69043524
11ECM-receptor interaction_Homo sapiens_hsa045121.64932174
12GABAergic synapse_Homo sapiens_hsa047271.62255828
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.62000759
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61136717
15Olfactory transduction_Homo sapiens_hsa047401.58152359
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.53929745
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52015090
18Type II diabetes mellitus_Homo sapiens_hsa049301.50397466
19Serotonergic synapse_Homo sapiens_hsa047261.48197481
20Axon guidance_Homo sapiens_hsa043601.47223982
21Synaptic vesicle cycle_Homo sapiens_hsa047211.45474089
22Calcium signaling pathway_Homo sapiens_hsa040201.44122253
23Amphetamine addiction_Homo sapiens_hsa050311.43658128
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43323200
25Phototransduction_Homo sapiens_hsa047441.42787072
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42176844
27Circadian entrainment_Homo sapiens_hsa047131.42021706
28Glycerolipid metabolism_Homo sapiens_hsa005611.41275948
29Fatty acid biosynthesis_Homo sapiens_hsa000611.39379956
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38367431
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38347745
32Gastric acid secretion_Homo sapiens_hsa049711.37998471
33Platelet activation_Homo sapiens_hsa046111.37719888
34Cocaine addiction_Homo sapiens_hsa050301.33350039
35Caffeine metabolism_Homo sapiens_hsa002321.32630400
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.32406968
37Dopaminergic synapse_Homo sapiens_hsa047281.31830288
38Renin secretion_Homo sapiens_hsa049241.25854257
39Cholinergic synapse_Homo sapiens_hsa047251.21917670
40Insulin secretion_Homo sapiens_hsa049111.16895576
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.13347846
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11201101
43Tryptophan metabolism_Homo sapiens_hsa003801.09437901
44cAMP signaling pathway_Homo sapiens_hsa040241.04650462
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03986177
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.03042537
47Butanoate metabolism_Homo sapiens_hsa006501.02943903
48Histidine metabolism_Homo sapiens_hsa003401.02141870
49Ether lipid metabolism_Homo sapiens_hsa005650.98326648
50Oxytocin signaling pathway_Homo sapiens_hsa049210.97708560
51Long-term potentiation_Homo sapiens_hsa047200.96719142
52Dorso-ventral axis formation_Homo sapiens_hsa043200.96509175
53Linoleic acid metabolism_Homo sapiens_hsa005910.96253925
54Malaria_Homo sapiens_hsa051440.96036785
55Protein digestion and absorption_Homo sapiens_hsa049740.95363905
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94520065
57Long-term depression_Homo sapiens_hsa047300.94331347
58Pancreatic secretion_Homo sapiens_hsa049720.93795449
59ErbB signaling pathway_Homo sapiens_hsa040120.92680366
60Fat digestion and absorption_Homo sapiens_hsa049750.92218746
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91319716
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89893176
63Melanogenesis_Homo sapiens_hsa049160.88914232
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86894250
65Nitrogen metabolism_Homo sapiens_hsa009100.86752605
66Dilated cardiomyopathy_Homo sapiens_hsa054140.86344562
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.85305059
68ABC transporters_Homo sapiens_hsa020100.84731701
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83483583
70Estrogen signaling pathway_Homo sapiens_hsa049150.81172789
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79732212
72Phenylalanine metabolism_Homo sapiens_hsa003600.79683080
73Chemical carcinogenesis_Homo sapiens_hsa052040.78573233
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78445825
75GnRH signaling pathway_Homo sapiens_hsa049120.78354246
76Ovarian steroidogenesis_Homo sapiens_hsa049130.77060412
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76419648
78Gap junction_Homo sapiens_hsa045400.73097883
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.69494510
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69214937
81Focal adhesion_Homo sapiens_hsa045100.66520437
82Ras signaling pathway_Homo sapiens_hsa040140.65943353
83Glioma_Homo sapiens_hsa052140.65167974
84Complement and coagulation cascades_Homo sapiens_hsa046100.64973838
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64597272
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.64552049
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62791157
88Thyroid hormone synthesis_Homo sapiens_hsa049180.61759614
89Lysine degradation_Homo sapiens_hsa003100.61429057
90Peroxisome_Homo sapiens_hsa041460.58999408
91Inositol phosphate metabolism_Homo sapiens_hsa005620.58500330
92Amoebiasis_Homo sapiens_hsa051460.57672345
93Prion diseases_Homo sapiens_hsa050200.57006100
94Wnt signaling pathway_Homo sapiens_hsa043100.56584173
95Collecting duct acid secretion_Homo sapiens_hsa049660.55111821
96Fatty acid elongation_Homo sapiens_hsa000620.54286558
97One carbon pool by folate_Homo sapiens_hsa006700.53961606
98PPAR signaling pathway_Homo sapiens_hsa033200.53888556
99Arachidonic acid metabolism_Homo sapiens_hsa005900.52863070
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.52506410
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52491929
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51893295
103Rap1 signaling pathway_Homo sapiens_hsa040150.51305313
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50639000
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50588162
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50578749
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.50023944
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48907831
109Proteoglycans in cancer_Homo sapiens_hsa052050.48760716
110Sulfur relay system_Homo sapiens_hsa041220.47871162
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47603965
112MicroRNAs in cancer_Homo sapiens_hsa052060.47517908
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.46148242
114Bile secretion_Homo sapiens_hsa049760.45223218
115Choline metabolism in cancer_Homo sapiens_hsa052310.45111781
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44907940
117Staphylococcus aureus infection_Homo sapiens_hsa051500.43461019
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43322951
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43320407
120Retinol metabolism_Homo sapiens_hsa008300.42705388
121MAPK signaling pathway_Homo sapiens_hsa040100.42182033
122Oocyte meiosis_Homo sapiens_hsa041140.41331726
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40338219
124Hematopoietic cell lineage_Homo sapiens_hsa046400.39832258
125Tyrosine metabolism_Homo sapiens_hsa003500.39625521
126Fanconi anemia pathway_Homo sapiens_hsa034600.39088924
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38588133
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38218150
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.35230052
130Cardiac muscle contraction_Homo sapiens_hsa042600.34241691
131Starch and sucrose metabolism_Homo sapiens_hsa005000.32115477
132Chemokine signaling pathway_Homo sapiens_hsa040620.31460764
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31102521
134Mineral absorption_Homo sapiens_hsa049780.31010108
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31004917
136African trypanosomiasis_Homo sapiens_hsa051430.30902765
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29941107

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