DSTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.68911084
2Golgi transport vesicle coating (GO:0048200)5.43679006
3COPI coating of Golgi vesicle (GO:0048205)5.43679006
4hemidesmosome assembly (GO:0031581)5.27603319
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.12885563
6sequestering of metal ion (GO:0051238)4.04622793
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.00567447
8epithelial cell-cell adhesion (GO:0090136)4.00265882
9regulation of cardioblast differentiation (GO:0051890)3.84169772
10wound healing, spreading of epidermal cells (GO:0035313)3.69465749
11membrane budding (GO:0006900)3.67954953
12protein retention in ER lumen (GO:0006621)3.62008354
13cell adhesion mediated by integrin (GO:0033627)3.61770332
14tight junction assembly (GO:0070830)3.59041804
15regulation of integrin-mediated signaling pathway (GO:2001044)3.54423477
16peptide catabolic process (GO:0043171)3.48065318
17type B pancreatic cell proliferation (GO:0044342)3.40544689
18endocardial cushion development (GO:0003197)3.37268770
19protein maturation by protein folding (GO:0022417)3.37209687
20regulation of water loss via skin (GO:0033561)3.30271892
21wound healing, spreading of cells (GO:0044319)3.28035135
22adhesion of symbiont to host cell (GO:0044650)3.26726980
23virion attachment to host cell (GO:0019062)3.26726980
24intestinal epithelial cell development (GO:0060576)3.26526076
25chondrocyte proliferation (GO:0035988)3.22413017
26cellular response to vitamin D (GO:0071305)3.16557001
27atrioventricular valve morphogenesis (GO:0003181)3.14577200
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.11648207
29skin morphogenesis (GO:0043589)3.08052934
30mesodermal cell differentiation (GO:0048333)3.04125664
31negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.01474726
32UDP-N-acetylglucosamine metabolic process (GO:0006047)3.01306939
33cardiac right ventricle morphogenesis (GO:0003215)3.00092610
34negative regulation of keratinocyte proliferation (GO:0010839)2.97932273
35positive regulation of endothelial cell apoptotic process (GO:2000353)2.96383009
36hydrogen peroxide catabolic process (GO:0042744)2.96065237
37cellular response to vitamin (GO:0071295)2.95766378
38keratinocyte differentiation (GO:0030216)2.92144128
39regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.91037430
40nucleotide-sugar biosynthetic process (GO:0009226)2.83937009
41establishment of skin barrier (GO:0061436)2.79178646
42endodermal cell differentiation (GO:0035987)2.77923783
43regulation of interleukin-8 secretion (GO:2000482)2.76524014
44COPII vesicle coating (GO:0048208)2.75430477
45regulation of transforming growth factor beta2 production (GO:0032909)2.75117752
46negative regulation of cell fate specification (GO:0009996)2.74097304
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73748269
48cellular response to interferon-alpha (GO:0035457)2.72992804
49extracellular fibril organization (GO:0043206)2.72910177
50surfactant homeostasis (GO:0043129)2.69622048
51calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.67850337
52keratinocyte proliferation (GO:0043616)2.66461041
53leukocyte migration involved in inflammatory response (GO:0002523)2.66240447
54peptide cross-linking (GO:0018149)2.64462499
55adhesion of symbiont to host (GO:0044406)2.64458124
56branching involved in prostate gland morphogenesis (GO:0060442)2.64173793
57collagen fibril organization (GO:0030199)2.64162594
58multicellular organismal water homeostasis (GO:0050891)2.64147883
59dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63997720
60sarcomere organization (GO:0045214)2.63506235
61lung secretory cell differentiation (GO:0061140)2.61836981
62negative regulation of striated muscle cell apoptotic process (GO:0010664)2.59120602
63hypotonic response (GO:0006971)2.56269125
64cyclooxygenase pathway (GO:0019371)2.55544984
65cellular copper ion homeostasis (GO:0006878)2.55150662
66positive regulation of pseudopodium assembly (GO:0031274)2.54616944
67regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.53990142
68cell-cell junction assembly (GO:0007043)2.53171029
69neutrophil activation involved in immune response (GO:0002283)2.52902672
70response to redox state (GO:0051775)2.51885471
71* positive regulation of actin filament depolymerization (GO:0030836)2.48953891
72regulation of transforming growth factor beta1 production (GO:0032908)2.48634204
73primary alcohol catabolic process (GO:0034310)2.47478853
74hippo signaling (GO:0035329)2.45789143
75actin-mediated cell contraction (GO:0070252)2.44932815
76hydrogen peroxide metabolic process (GO:0042743)2.44720241
77hepatocyte apoptotic process (GO:0097284)2.43784294
78muscle cell migration (GO:0014812)2.42882473
79regulation of metalloenzyme activity (GO:0048552)2.41028026
80signal peptide processing (GO:0006465)2.40346060
81* actin filament depolymerization (GO:0030042)2.39820517
82negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.39783992
83antibacterial humoral response (GO:0019731)2.39555660
84endothelial cell morphogenesis (GO:0001886)2.39125947
85positive regulation of protein autophosphorylation (GO:0031954)2.38993757
86negative regulation of chondrocyte differentiation (GO:0032331)2.38053331
87daunorubicin metabolic process (GO:0044597)2.36536914
88polyketide metabolic process (GO:0030638)2.36536914
89doxorubicin metabolic process (GO:0044598)2.36536914
90sequestering of actin monomers (GO:0042989)2.36173356
91negative regulation of cell fate commitment (GO:0010454)2.34722346
92ventricular cardiac muscle cell development (GO:0055015)2.34341234
93regulation of chemokine secretion (GO:0090196)2.32897627
94paraxial mesoderm development (GO:0048339)2.32665386
95ectoderm development (GO:0007398)2.31856921
96proteasome assembly (GO:0043248)2.31456867
97positive regulation of glycoprotein metabolic process (GO:1903020)2.31151112
98chemical homeostasis within a tissue (GO:0048875)2.30825461
99interferon-gamma secretion (GO:0072643)2.30534509
100positive regulation of p38MAPK cascade (GO:1900745)2.30067919
101sphingoid metabolic process (GO:0046519)2.29680772
102sequestering of extracellular ligand from receptor (GO:0035581)2.29598448
103regulation of secondary heart field cardioblast proliferation (GO:0003266)2.27914775
104regulation of cardioblast proliferation (GO:0003264)2.27914775
105tonic smooth muscle contraction (GO:0014820)2.27026215
106epidermal cell differentiation (GO:0009913)2.26298667
107prostanoid metabolic process (GO:0006692)2.25834511
108prostaglandin metabolic process (GO:0006693)2.25834511
109muscle filament sliding (GO:0030049)2.25676208
110actin-myosin filament sliding (GO:0033275)2.25676208
111glutamate secretion (GO:0014047)2.25288937
112regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.24807331
113cell-substrate junction assembly (GO:0007044)2.24668454
114activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.24356203
115prostanoid biosynthetic process (GO:0046457)2.24025484
116prostaglandin biosynthetic process (GO:0001516)2.24025484
117regulation of cell fate specification (GO:0042659)2.23176656
118protein localization to cell surface (GO:0034394)2.22952059
119positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.22515127
120intestinal absorption (GO:0050892)2.22424648
121cullin deneddylation (GO:0010388)2.22172125
122retina vasculature morphogenesis in camera-type eye (GO:0061299)2.21939324
123regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.21451820
124peptidyl-cysteine modification (GO:0018198)2.19217714
125vesicle coating (GO:0006901)2.18857283
126regulation of type B pancreatic cell apoptotic process (GO:2000674)2.18488441
127substrate adhesion-dependent cell spreading (GO:0034446)2.17118977
128positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.15694220
129gap junction assembly (GO:0016264)2.15634501
130aminoglycoside antibiotic metabolic process (GO:0030647)2.14997834
131protein heterotrimerization (GO:0070208)2.14255560
132extracellular negative regulation of signal transduction (GO:1900116)2.12168700
133extracellular regulation of signal transduction (GO:1900115)2.12168700
134lipid particle organization (GO:0034389)2.11854045
135apical protein localization (GO:0045176)2.09646915
136vascular smooth muscle contraction (GO:0014829)2.08534517
137kidney mesenchyme development (GO:0072074)2.08334681
138regulation of cell communication by electrical coupling (GO:0010649)2.08232296
139endocrine hormone secretion (GO:0060986)2.07999853
140smooth muscle tissue development (GO:0048745)2.06494383
141peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.05525221
142mesenchymal-epithelial cell signaling (GO:0060638)2.05475581
143peptidyl-proline hydroxylation (GO:0019511)2.02625398
144establishment of planar polarity (GO:0001736)2.02500888
145establishment of tissue polarity (GO:0007164)2.02500888
146L-serine transport (GO:0015825)2.01203252
147protein hydroxylation (GO:0018126)2.01136117
148metanephric mesenchyme development (GO:0072075)2.00965078
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.00590176
150keratan sulfate catabolic process (GO:0042340)2.00302642
151protein deneddylation (GO:0000338)1.99750040
152negative regulation of stem cell proliferation (GO:2000647)1.99150135
153extracellular matrix assembly (GO:0085029)1.99089091
154regulation of glomerular filtration (GO:0003093)1.98382815
155positive regulation of protein targeting to membrane (GO:0090314)1.96361628
156fibril organization (GO:0097435)1.94433103
157synaptic vesicle docking involved in exocytosis (GO:0016081)1.93540779
158substrate-dependent cell migration (GO:0006929)1.92961287
159mitochondrial electron transport, NADH to ubiquinone (GO:0006120)1.91714815
160regulation of protein localization to cell surface (GO:2000008)1.91102572
161cell communication involved in cardiac conduction (GO:0086065)1.89665591
162glomerular epithelial cell development (GO:0072310)1.85309929
163negative regulation of protein localization to cell surface (GO:2000009)1.85224353
164mitochondrial ATP synthesis coupled proton transport (GO:0042776)1.85214650
165membrane assembly (GO:0071709)1.84065054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.84045402
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.20900074
3* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.69431540
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.32781655
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21277950
6SOX2_20726797_ChIP-Seq_SW620_Human2.83682408
7CLOCK_20551151_ChIP-Seq_293T_Human2.75979229
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71669519
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.62537511
10* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.48815956
11* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.48815956
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.36765582
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.35729943
14CJUN_26792858_Chip-Seq_BT549_Human2.23575684
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22597674
16* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.16844034
17* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.09236736
18* SALL4_18804426_ChIP-ChIP_XEN_Mouse2.05182965
19TP63_17297297_ChIP-ChIP_HaCaT_Human10.0477118
20GATA4_25053715_ChIP-Seq_YYC3_Human1.99167616
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87459908
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.86245361
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80931161
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78885414
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78885414
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.75752314
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.74520458
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73914116
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.73196100
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.70950564
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.70324822
32* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63583286
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60783632
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60676314
35ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.60614792
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60537137
37* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57723272
38* ESR1_20079471_ChIP-ChIP_T-47D_Human1.53782287
39* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.53392809
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.51928065
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51429559
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51424310
43* GATA3_24758297_ChIP-Seq_MCF-7_Human1.50356645
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46368885
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44549528
46GATA6_25053715_ChIP-Seq_YYC3_Human1.43997731
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41346069
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.41301622
49AR_21909140_ChIP-Seq_LNCAP_Human1.40292739
50* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.39293983
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38625683
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35237763
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34990265
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33989907
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32993481
56BRD4_25478319_ChIP-Seq_HGPS_Human1.32729295
57AHR_22903824_ChIP-Seq_MCF-7_Human1.32256747
58* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32092033
59GBX2_23144817_ChIP-Seq_PC3_Human1.31583412
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31377830
61* ATF3_27146783_Chip-Seq_COLON_Human1.30664141
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30333085
63* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30043622
64TP53_18474530_ChIP-ChIP_U2OS_Human1.28541608
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26902917
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26402052
67EOMES_21245162_ChIP-Seq_HESCs_Human1.25848640
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25677365
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25645966
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25162708
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25056110
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25056110
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25056110
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24619208
75ELK1_19687146_ChIP-ChIP_HELA_Human1.23780801
76* KLF5_25053715_ChIP-Seq_YYC3_Human1.21074647
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19057155
78TP63_23658742_ChIP-Seq_EP156T_Human1.17406546
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15017814
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.14316894
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.11526579
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09080800
83SMAD4_21799915_ChIP-Seq_A2780_Human1.08788918
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08574465
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07868487
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07589042
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07535997
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07227439
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06973994
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.06332401
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05432448
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.05113835
93* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04453397
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.04185420
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.03756700
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02665737
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02375184
98* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00424222
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00321956
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00320209
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99806520
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99354202
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98989638
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98492692
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98424065
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98141359
107ZNF263_19887448_ChIP-Seq_K562_Human0.97011691
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93931863
109P300_19829295_ChIP-Seq_ESCs_Human0.92285052
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91533152
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91021425
112* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89999132
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.89570758
114FUS_26573619_Chip-Seq_HEK293_Human0.89148761
115RUNX1_27514584_Chip-Seq_MCF-7_Human0.88767944
116MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88439544
117RACK7_27058665_Chip-Seq_MCF-7_Human0.87782252
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86876203
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86482128
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86048395
121TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84203791
122TAF15_26573619_Chip-Seq_HEK293_Human0.84132820
123TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84127202
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83238902
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83134037
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82887960
127GABP_17652178_ChIP-ChIP_JURKAT_Human0.82679211
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.81648342
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81427823
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81235737
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80785095
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80443698
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79938762
134ELF5_23300383_ChIP-Seq_T47D_Human0.79685133
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78960066
136CHD1_26751641_Chip-Seq_LNCaP_Human0.78039194
137NELFA_20434984_ChIP-Seq_ESCs_Mouse0.77297378
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.77190183
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.75810815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.91748707
2MP0005275_abnormal_skin_tensile3.71852277
3MP0008438_abnormal_cutaneous_collagen3.42591637
4MP0003941_abnormal_skin_development3.29013119
5MP0006054_spinal_hemorrhage3.00653379
6MP0003566_abnormal_cell_adhesion2.87221175
7MP0004272_abnormal_basement_membrane2.75417846
8MP0010352_gastrointestinal_tract_polyps2.71093009
9MP0003705_abnormal_hypodermis_morpholog2.69649927
10MP0000537_abnormal_urethra_morphology2.68827707
11MP0002796_impaired_skin_barrier2.44179624
12MP0002877_abnormal_melanocyte_morpholog2.38068323
13MP0001958_emphysema2.10823025
14MP0008004_abnormal_stomach_pH2.08756288
15MP0001346_abnormal_lacrimal_gland2.07773348
16MP0009384_cardiac_valve_regurgitation2.01131449
17MP0002060_abnormal_skin_morphology1.98021908
18MP0000516_abnormal_urinary_system1.96675097
19MP0005367_renal/urinary_system_phenotyp1.96675097
20MP0010368_abnormal_lymphatic_system1.94923333
21MP0005503_abnormal_tendon_morphology1.90724597
22MP0004264_abnormal_extraembryonic_tissu1.85302505
23MP0004782_abnormal_surfactant_physiolog1.85013592
24MP0005257_abnormal_intraocular_pressure1.79567397
25MP0003950_abnormal_plasma_membrane1.79459843
26MP0010386_abnormal_urinary_bladder1.76716941
27MP0005023_abnormal_wound_healing1.76031066
28MP0002254_reproductive_system_inflammat1.72487079
29MP0005501_abnormal_skin_physiology1.65856912
30MP0009053_abnormal_anal_canal1.65281349
31MP0002295_abnormal_pulmonary_circulatio1.60392571
32MP0000751_myopathy1.55014859
33MP0002098_abnormal_vibrissa_morphology1.53893280
34MP0010678_abnormal_skin_adnexa1.49323355
35MP0003453_abnormal_keratinocyte_physiol1.49318343
36MP0001542_abnormal_bone_strength1.48713150
37MP0010030_abnormal_orbit_morphology1.46296372
38MP0000462_abnormal_digestive_system1.44600514
39MP0005408_hypopigmentation1.44386203
40MP0000762_abnormal_tongue_morphology1.42405083
41MP0001216_abnormal_epidermal_layer1.40351522
42MP0005623_abnormal_meninges_morphology1.38651884
43MP0004084_abnormal_cardiac_muscle1.37355194
44MP0003279_aneurysm1.36308157
45MP0000538_abnormal_urinary_bladder1.29134696
46MP0003091_abnormal_cell_migration1.26950874
47MP0004270_analgesia1.24761300
48MP0000467_abnormal_esophagus_morphology1.23593912
49MP0004215_abnormal_myocardial_fiber1.22425878
50MP0003186_abnormal_redox_activity1.16417882
51MP0002009_preneoplasia1.13790062
52MP0002896_abnormal_bone_mineralization1.12987794
53MP0002282_abnormal_trachea_morphology1.12063083
54MP0010771_integument_phenotype1.11616792
55MP0005164_abnormal_response_to1.10468499
56MP0000566_synostosis1.09019951
57MP0000579_abnormal_nail_morphology1.08411243
58MP0003385_abnormal_body_wall1.06917393
59MP0002972_abnormal_cardiac_muscle1.06629089
60MP0003806_abnormal_nucleotide_metabolis1.03188580
61MP0000627_abnormal_mammary_gland1.02644016
62MP0005248_abnormal_Harderian_gland1.01917777
63MP0005330_cardiomyopathy1.00472269
64MP0005165_increased_susceptibility_to1.00442406
65MP0002909_abnormal_adrenal_gland1.00299792
66MP0000013_abnormal_adipose_tissue0.97331120
67MP0005076_abnormal_cell_differentiation0.96466654
68MP0000383_abnormal_hair_follicle0.96187701
69MP0000749_muscle_degeneration0.96149302
70MP0005508_abnormal_skeleton_morphology0.96020960
71MP0000377_abnormal_hair_follicle0.90354454
72MP0001881_abnormal_mammary_gland0.87862928
73MP0009780_abnormal_chondrocyte_physiolo0.87515810
74MP0001849_ear_inflammation0.87344055
75MP0001243_abnormal_dermal_layer0.87110589
76MP0002108_abnormal_muscle_morphology0.86814468
77MP0002837_dystrophic_cardiac_calcinosis0.86813957
78MP0002133_abnormal_respiratory_system0.86438310
79MP0005388_respiratory_system_phenotype0.86438310
80MP0001666_abnormal_nutrient_absorption0.85877001
81MP0000534_abnormal_ureter_morphology0.85321213
82MP0008775_abnormal_heart_ventricle0.84977589
83MP0004859_abnormal_synaptic_plasticity0.84470363
84MP0001533_abnormal_skeleton_physiology0.84378239
85MP0002090_abnormal_vision0.84218602
86MP0005620_abnormal_muscle_contractility0.83572335
87MP0001984_abnormal_olfaction0.83568664
88MP0000163_abnormal_cartilage_morphology0.83403388
89MP0003123_paternal_imprinting0.83208835
90MP0009379_abnormal_foot_pigmentation0.82546421
91MP0009250_abnormal_appendicular_skeleto0.81698542
92MP0000647_abnormal_sebaceous_gland0.81491209
93MP0000858_altered_metastatic_potential0.81290744
94MP0004085_abnormal_heartbeat0.78427086
95MP0000767_abnormal_smooth_muscle0.78072403
96MP0003937_abnormal_limbs/digits/tail_de0.78025635
97MP0001177_atelectasis0.77736133
98MP0005197_abnormal_uvea_morphology0.77510279
99MP0000613_abnormal_salivary_gland0.77495019
100MP0003942_abnormal_urinary_system0.77238123
101MP0005187_abnormal_penis_morphology0.76688608
102MP0002233_abnormal_nose_morphology0.76011328
103MP0000427_abnormal_hair_cycle0.75585211
104MP0004883_abnormal_blood_vessel0.75433878
105MP0003315_abnormal_perineum_morphology0.75178075
106MP0003880_abnormal_central_pattern0.75115625
107MP0003755_abnormal_palate_morphology0.74878145
108MP0005595_abnormal_vascular_smooth0.74309471
109MP0005084_abnormal_gallbladder_morpholo0.74024893
110MP0003183_abnormal_peptide_metabolism0.73498985
111MP0006138_congestive_heart_failure0.73067262
112MP0004947_skin_inflammation0.72722031
113MP0005390_skeleton_phenotype0.72477981
114MP0001529_abnormal_vocalization0.72199571
115* MP0001879_abnormal_lymphatic_vessel0.72087011
116MP0002734_abnormal_mechanical_nocicepti0.72048498
117MP0003119_abnormal_digestive_system0.71512223
118MP0000003_abnormal_adipose_tissue0.71173499
119MP0001664_abnormal_digestion0.70822342
120MP0001299_abnormal_eye_distance/0.70335657
121MP0002177_abnormal_outer_ear0.70155039
122MP0001191_abnormal_skin_condition0.69987070
123MP0002277_abnormal_respiratory_mucosa0.69772839
124MP0001756_abnormal_urination0.69297495
125MP0002163_abnormal_gland_morphology0.68839743
126MP0003283_abnormal_digestive_organ0.67721462
127MP0000470_abnormal_stomach_morphology0.67160085
128MP0002168_other_aberrant_phenotype0.65660613
129MP0004484_altered_response_of0.65409712
130MP0003137_abnormal_impulse_conducting0.63836160
131MP0004036_abnormal_muscle_relaxation0.62839712
132MP0002234_abnormal_pharynx_morphology0.61710124
133MP0002160_abnormal_reproductive_system0.60612625

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.20957109
2Atrophic scars (HP:0001075)4.40475224
3Aortic aneurysm (HP:0004942)4.04261772
4Premature rupture of membranes (HP:0001788)3.71250549
5Onycholysis (HP:0001806)3.51990382
6Aortic dissection (HP:0002647)3.47432774
7Fragile nails (HP:0001808)3.15785224
8Milia (HP:0001056)2.99785971
9Ileus (HP:0002595)2.84486251
10Abnormality of dentin (HP:0010299)2.84255105
11Cervical subluxation (HP:0003308)2.83221002
12Protrusio acetabuli (HP:0003179)2.77947388
13Curly hair (HP:0002212)2.76685293
14Plantar hyperkeratosis (HP:0007556)2.74430184
15Woolly hair (HP:0002224)2.62857243
16Distal lower limb muscle weakness (HP:0009053)2.59712927
17Wormian bones (HP:0002645)2.53190226
18Micronodular cirrhosis (HP:0001413)2.50017920
19Congenital ichthyosiform erythroderma (HP:0007431)2.49277079
20Osteolytic defects of the hand bones (HP:0009699)2.45684920
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.45684920
22Vertebral hypoplasia (HP:0008417)2.44899880
23Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.44899880
24Ventricular tachycardia (HP:0004756)2.43300346
25Fragile skin (HP:0001030)2.40181731
26Peritonitis (HP:0002586)2.38499747
27Short nail (HP:0001799)2.34630213
28Abnormality of the distal phalanges of the toes (HP:0010182)2.32362151
29Gastrointestinal dysmotility (HP:0002579)2.31525101
30Conjunctival hamartoma (HP:0100780)2.31184216
31Neonatal short-limb short stature (HP:0008921)2.30459057
32Hydroureter (HP:0000072)2.29537625
33Spinal rigidity (HP:0003306)2.29225080
34Short hallux (HP:0010109)2.23915215
35Pterygium (HP:0001059)2.21017159
36Ankle contracture (HP:0006466)2.20861544
37Hyperactive renin-angiotensin system (HP:0000841)2.20852804
38Abnormal foot bone ossification (HP:0010675)2.15286130
39Subacute progressive viral hepatitis (HP:0006572)2.14819676
40Cupped ribs (HP:0000887)2.14480185
41Pili torti (HP:0003777)2.14115801
42Dilatation of the ascending aorta (HP:0005111)2.12996115
43Bladder diverticulum (HP:0000015)2.12941163
44Cerebral aneurysm (HP:0004944)2.10198008
45Mitral stenosis (HP:0001718)2.10003498
46Aplasia/Hypoplasia of the hallux (HP:0008362)2.09947034
47Vascular tortuosity (HP:0004948)2.08654123
48Scapular winging (HP:0003691)2.07981750
49Malnutrition (HP:0004395)2.07838446
50Broad metatarsal (HP:0001783)2.07324328
51Palpitations (HP:0001962)2.06251771
52Abnormality of the 2nd finger (HP:0004100)2.03849068
53Abnormal hemoglobin (HP:0011902)2.02921679
54Interstitial pulmonary disease (HP:0006530)2.02907531
55Mildly elevated creatine phosphokinase (HP:0008180)2.00722501
56Flat acetabular roof (HP:0003180)2.00325232
57Fused cervical vertebrae (HP:0002949)1.99547357
58Hypoplasia of dental enamel (HP:0006297)1.99100851
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98309136
60Soft skin (HP:0000977)1.92683400
61Hand muscle atrophy (HP:0009130)1.92417610
62Delayed gross motor development (HP:0002194)1.92298646
63Nail dystrophy (HP:0008404)1.91755178
64Abnormal pancreas size (HP:0012094)1.91236474
65Natal tooth (HP:0000695)1.90660318
66Hydroxyprolinuria (HP:0003080)1.89811845
67Abnormality of proline metabolism (HP:0010907)1.89811845
68Hoarse voice (HP:0001609)1.89301327
69Abnormality of the distal phalanx of the thumb (HP:0009617)1.88249111
70Hyperparathyroidism (HP:0000843)1.87927707
71Glucose intolerance (HP:0000833)1.87517153
72Epiphyseal dysplasia (HP:0002656)1.86686730
73Cardiovascular calcification (HP:0011915)1.86076915
74Trismus (HP:0000211)1.85105270
75Increased connective tissue (HP:0009025)1.84926845
76Tetraparesis (HP:0002273)1.84415733
77Hyporeflexia of lower limbs (HP:0002600)1.82793000
78Microglossia (HP:0000171)1.82383274
79Abnormality of the calcaneus (HP:0008364)1.82330094
80Asymmetry of the thorax (HP:0001555)1.81649565
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81096751
82Patent foramen ovale (HP:0001655)1.80757176
83Rhinitis (HP:0012384)1.80545662
84Xerostomia (HP:0000217)1.79133406
85Abnormality of chloride homeostasis (HP:0011422)1.78186890
86Shallow orbits (HP:0000586)1.78141149
87Follicular hyperkeratosis (HP:0007502)1.78081362
88Palmoplantar hyperkeratosis (HP:0000972)1.77217169
89Tarsal synostosis (HP:0008368)1.77045533
90Distal upper limb amyotrophy (HP:0007149)1.76714469
91Upper limb amyotrophy (HP:0009129)1.76714469
92Tibial bowing (HP:0002982)1.75398557
93Limb-girdle muscle atrophy (HP:0003797)1.73741443
94Platyspondyly (HP:0000926)1.73162493
95Type 1 muscle fiber predominance (HP:0003803)1.72534737
96Bundle branch block (HP:0011710)1.72335713
97Short humerus (HP:0005792)1.72170782
98Abnormal vertebral ossification (HP:0100569)1.72142451
99Abdominal distention (HP:0003270)1.71499778
100Stenosis of the external auditory canal (HP:0000402)1.71355064
101Vertebral compression fractures (HP:0002953)1.70737300
102Congenital glaucoma (HP:0001087)1.70466600
103Thin bony cortex (HP:0002753)1.70106741
104Coronal craniosynostosis (HP:0004440)1.68446197
105Abnormal cartilage morphology (HP:0002763)1.68022977
106Hypoplastic labia majora (HP:0000059)1.67993629
107Palmar hyperkeratosis (HP:0010765)1.66214248
108Bilateral sensorineural hearing impairment (HP:0008619)1.65973365
109Arterial tortuosity (HP:0005116)1.65661760
110Spinal cord compression (HP:0002176)1.65612841
111Anhidrosis (HP:0000970)1.65503648
112Femoral bowing (HP:0002980)1.65452044
113Abnormal biliary tract morphology (HP:0012440)1.65269860
114Abnormality of the gastric mucosa (HP:0004295)1.64752976
115Parakeratosis (HP:0001036)1.64506765
116Abnormality of the proximal phalanges of the hand (HP:0009834)1.64157614
117Vascular calcification (HP:0004934)1.63966107
118Bowel diverticulosis (HP:0005222)1.60737900
119Bradycardia (HP:0001662)1.57570899
120Abnormal delivery (HP:0001787)1.56824214
121Infantile muscular hypotonia (HP:0008947)1.55470938
122Adrenal hypoplasia (HP:0000835)1.54639573
123Abnormality of molar (HP:0011077)1.52668569
124Abnormality of molar morphology (HP:0011070)1.52668569
125Sparse eyelashes (HP:0000653)1.51602320
126Acute necrotizing encephalopathy (HP:0006965)1.50737631
127Hypoglycemic coma (HP:0001325)1.50455880
128Hyperextensible skin (HP:0000974)1.49612300
129Reduced subcutaneous adipose tissue (HP:0003758)1.48378861
130Aortic regurgitation (HP:0001659)1.47517039
131Wrist flexion contracture (HP:0001239)1.46865719
132Increased serum pyruvate (HP:0003542)1.44836974
133Abnormality of the calf musculature (HP:0001430)1.44812559
134Abnormal respiratory motile cilium physiology (HP:0012261)1.44651914
135Sensory axonal neuropathy (HP:0003390)1.44122271
136Chronic bronchitis (HP:0004469)1.44078125
137Buphthalmos (HP:0000557)1.42838828
138Alopecia of scalp (HP:0002293)1.42138838
139Long toe (HP:0010511)1.42043780
140Absent frontal sinuses (HP:0002688)1.41869114
141Popliteal pterygium (HP:0009756)1.41839042
142Hypokinesia (HP:0002375)1.41816033
143Abnormality of glycolysis (HP:0004366)1.41198195
144Blue sclerae (HP:0000592)1.40385677
145Hypoplastic left heart (HP:0004383)1.40178701
146Progressive macrocephaly (HP:0004481)1.39726103
147Bell-shaped thorax (HP:0001591)1.38691929
148Autoamputation (HP:0001218)1.38566992
149Nuclear cataract (HP:0100018)1.38451502
150Upper limb muscle weakness (HP:0003484)1.37961627
151Limb-girdle muscle weakness (HP:0003325)1.37395305
152Redundant skin (HP:0001582)1.36997285
153Torticollis (HP:0000473)1.36483814
154Metaphyseal dysplasia (HP:0100255)1.34727516
155Abnormality of carpal bone ossification (HP:0006257)1.34707062
156Aortic valve stenosis (HP:0001650)1.34684694
157Elbow flexion contracture (HP:0002987)1.34650525
158Osteopenia (HP:0000938)1.34267657
159Sudden death (HP:0001699)1.33117707
160Abnormal mitochondria in muscle tissue (HP:0008316)1.32332569
161Knee flexion contracture (HP:0006380)1.31206515
162Abnormality of the umbilical cord (HP:0010881)1.31109762
163Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.30514919
164Abnormality of the acetabulum (HP:0003170)1.30370927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.07814010
2MYLK3.91526798
3MST43.70308337
4FRK3.41239671
5ERBB32.92649226
6TRIM282.48314867
7MAP3K32.34618556
8MST1R2.32313190
9BCR2.31213750
10TRPM72.22284886
11FER2.18155302
12MET2.13916088
13EPHB22.10718491
14MAP3K22.09362496
15STK38L2.08987320
16PBK1.97551014
17PIK3CA1.93387639
18ZAK1.89158112
19LMTK21.87157462
20TTN1.86388519
21TESK21.73559307
22LATS11.63773780
23DDR21.61592203
24MAPKAPK31.59816374
25PAK31.48447426
26PIK3CG1.47640814
27AKT31.46890965
28STK241.43095502
29PTK21.41912600
30RPS6KB21.37877089
31PTK61.32454937
32PIM21.30128750
33NUAK11.29239690
34MAP2K21.28625217
35MINK11.28151178
36STK391.21312302
37PAK41.16411942
38MARK11.13984572
39LRRK21.12708149
40ILK1.12154555
41MAP2K11.12152729
42PRKG21.10569211
43CASK1.07698822
44OBSCN0.99235576
45SIK30.96277676
46STK30.95596246
47SCYL20.95501835
48BRSK20.95442822
49DMPK0.94578460
50PAK20.94322669
51WNK40.93751008
52MAP3K120.89502009
53NEK90.89125888
54ROCK10.88722032
55PNCK0.88357314
56NEK10.84648314
57TSSK60.84627238
58DAPK30.84387613
59EIF2AK30.84189437
60BMPR1B0.83518396
61PHKG10.83411824
62PHKG20.83411824
63EPHA40.82131352
64STK380.79634430
65EPHB10.78697684
66CAMK2B0.78255321
67STK160.78067847
68MAP3K140.77892392
69ERBB40.77727330
70PDGFRA0.77513301
71PDK20.77044439
72WNK30.75283395
73STK100.74365913
74LATS20.74230260
75BRSK10.73947120
76PRKCI0.73302390
77CDC42BPA0.73144523
78RIPK10.71604214
79* LIMK10.69351419
80PAK10.66868880
81ERN10.65771842
82MAP3K110.65329344
83DAPK10.65281984
84MAP2K70.64561460
85EPHA30.63984402
86CAMK2A0.62271951
87TIE10.61869961
88PLK20.61404606
89MAPKAPK20.60175840
90CSNK1A1L0.58530994
91CSNK1G30.58351664
92FGFR10.57778341
93CSNK1G10.57703597
94CSNK1G20.57616611
95ABL20.55221586
96NME10.54824138
97PTK2B0.53830073
98PLK30.53603066
99CDK180.52721077
100CDK140.52079499
101MAP3K90.51977982
102RPS6KA40.51874405
103GRK10.51859028
104GRK50.51838374
105PRKCE0.51309038
106TTK0.50963715
107MAP3K80.50881543
108TGFBR10.50503186
109MAPK150.49573719
110PRKD30.49467793
111AURKB0.49118916
112TGFBR20.48809066
113PAK60.48770462
114PRKCG0.48248903
115NME20.45977802
116BMPR20.45464736
117VRK20.44587955
118FLT30.43503373
119KSR10.42932683
120CAMK2D0.42889277
121EIF2AK10.41613100
122BMX0.41529581
123MUSK0.40787051
124WEE10.40667958
125CDK60.38636392
126ROCK20.38096694
127ERBB20.34343911
128PASK0.33851716
129GSK3A0.33765932
130ACVR1B0.33542528
131KSR20.32170529
132RPS6KA20.32149359
133PKN20.30907787
134EGFR0.30884888
135CHUK0.30262460
136EIF2AK20.29141690
137ARAF0.28477039
138NTRK10.27522628
139CAMK2G0.26396123

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.70496752
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.92536966
3Tight junction_Homo sapiens_hsa045302.45730346
4Vibrio cholerae infection_Homo sapiens_hsa051102.32614823
5Adherens junction_Homo sapiens_hsa045202.31323690
6ECM-receptor interaction_Homo sapiens_hsa045122.27973360
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27485496
8Protein export_Homo sapiens_hsa030602.27076583
9Glutathione metabolism_Homo sapiens_hsa004802.26850029
10Mineral absorption_Homo sapiens_hsa049782.15559241
11Proteasome_Homo sapiens_hsa030502.07202024
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.03406970
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.87295599
14Hippo signaling pathway_Homo sapiens_hsa043901.83045149
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.80057803
16Focal adhesion_Homo sapiens_hsa045101.78025597
17Fatty acid elongation_Homo sapiens_hsa000621.74217002
18Arachidonic acid metabolism_Homo sapiens_hsa005901.69093957
19Bladder cancer_Homo sapiens_hsa052191.64288508
20TGF-beta signaling pathway_Homo sapiens_hsa043501.63173371
21Amoebiasis_Homo sapiens_hsa051461.61699319
22Vitamin B6 metabolism_Homo sapiens_hsa007501.57599979
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54881738
24Folate biosynthesis_Homo sapiens_hsa007901.54594921
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54444902
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.54162102
27Phagosome_Homo sapiens_hsa041451.51376591
28Legionellosis_Homo sapiens_hsa051341.47835499
29Proteoglycans in cancer_Homo sapiens_hsa052051.44135439
30Oxidative phosphorylation_Homo sapiens_hsa001901.38659527
31Sphingolipid metabolism_Homo sapiens_hsa006001.35687950
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32717361
33Protein digestion and absorption_Homo sapiens_hsa049741.32626882
34Pyruvate metabolism_Homo sapiens_hsa006201.31594746
35Synaptic vesicle cycle_Homo sapiens_hsa047211.30988736
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30293473
37Salmonella infection_Homo sapiens_hsa051321.23905458
38Renin-angiotensin system_Homo sapiens_hsa046141.20155784
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19187046
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18757471
41Galactose metabolism_Homo sapiens_hsa000521.17625417
42p53 signaling pathway_Homo sapiens_hsa041151.17290119
43beta-Alanine metabolism_Homo sapiens_hsa004101.13851330
44Shigellosis_Homo sapiens_hsa051311.11105265
45Pertussis_Homo sapiens_hsa051331.10250086
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09651250
47Small cell lung cancer_Homo sapiens_hsa052221.08236038
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07851057
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07743942
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06614225
51Dilated cardiomyopathy_Homo sapiens_hsa054141.05432329
52Propanoate metabolism_Homo sapiens_hsa006401.03717972
53Parkinsons disease_Homo sapiens_hsa050121.02393498
54Rheumatoid arthritis_Homo sapiens_hsa053231.01316885
55Viral myocarditis_Homo sapiens_hsa054161.00687193
56Histidine metabolism_Homo sapiens_hsa003400.99694054
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99580216
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95844754
59Starch and sucrose metabolism_Homo sapiens_hsa005000.93844386
60Fat digestion and absorption_Homo sapiens_hsa049750.92846632
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92146782
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.91212795
63Thyroid cancer_Homo sapiens_hsa052160.89240666
64Circadian rhythm_Homo sapiens_hsa047100.88877311
65Chemical carcinogenesis_Homo sapiens_hsa052040.88032959
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85937050
67Alzheimers disease_Homo sapiens_hsa050100.85298498
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84766561
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83902184
70Phenylalanine metabolism_Homo sapiens_hsa003600.83432036
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83424279
72TNF signaling pathway_Homo sapiens_hsa046680.82793354
73Arginine and proline metabolism_Homo sapiens_hsa003300.82208278
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82015908
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81554567
76Carbon metabolism_Homo sapiens_hsa012000.81128801
77Malaria_Homo sapiens_hsa051440.80594519
78Insulin secretion_Homo sapiens_hsa049110.80003551
79Thyroid hormone synthesis_Homo sapiens_hsa049180.78413089
80Toxoplasmosis_Homo sapiens_hsa051450.78076552
81Leishmaniasis_Homo sapiens_hsa051400.77073481
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76572831
83MicroRNAs in cancer_Homo sapiens_hsa052060.74856736
84Apoptosis_Homo sapiens_hsa042100.74776174
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73744989
86Cocaine addiction_Homo sapiens_hsa050300.73547658
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72368207
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72271853
89Axon guidance_Homo sapiens_hsa043600.72117296
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71656876
91Amphetamine addiction_Homo sapiens_hsa050310.71218833
92N-Glycan biosynthesis_Homo sapiens_hsa005100.70670759
93Huntingtons disease_Homo sapiens_hsa050160.70083183
94Lysosome_Homo sapiens_hsa041420.68928324
95Melanoma_Homo sapiens_hsa052180.68884284
96GABAergic synapse_Homo sapiens_hsa047270.67671832
97Dopaminergic synapse_Homo sapiens_hsa047280.67667715
98Fatty acid degradation_Homo sapiens_hsa000710.67134788
99Linoleic acid metabolism_Homo sapiens_hsa005910.66181717
100Steroid biosynthesis_Homo sapiens_hsa001000.65063308
101Cardiac muscle contraction_Homo sapiens_hsa042600.64209046
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63693973
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62371582
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62370859
105Fructose and mannose metabolism_Homo sapiens_hsa000510.60693417
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60240961
107Oocyte meiosis_Homo sapiens_hsa041140.60200414
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60004808
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59988333
110Basal cell carcinoma_Homo sapiens_hsa052170.59910577
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59510671
112Melanogenesis_Homo sapiens_hsa049160.59311985
113Biosynthesis of amino acids_Homo sapiens_hsa012300.59119950
114Gap junction_Homo sapiens_hsa045400.57796601
115Pancreatic secretion_Homo sapiens_hsa049720.56616078
116Hepatitis C_Homo sapiens_hsa051600.56564068
117Pentose phosphate pathway_Homo sapiens_hsa000300.56563525
118Fatty acid metabolism_Homo sapiens_hsa012120.56523141
119Collecting duct acid secretion_Homo sapiens_hsa049660.56375108
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56116607
121Nicotine addiction_Homo sapiens_hsa050330.55802275
122Renin secretion_Homo sapiens_hsa049240.55499352
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54438205
124Salivary secretion_Homo sapiens_hsa049700.54355913
125Prostate cancer_Homo sapiens_hsa052150.53529620
126Metabolic pathways_Homo sapiens_hsa011000.52500038
127Circadian entrainment_Homo sapiens_hsa047130.51832991
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.51711377
129Gastric acid secretion_Homo sapiens_hsa049710.49992339
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.49967206
131Glutamatergic synapse_Homo sapiens_hsa047240.49520060
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.48932894
133Ether lipid metabolism_Homo sapiens_hsa005650.48586823
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.48218525
135Hedgehog signaling pathway_Homo sapiens_hsa043400.47861073
136Endometrial cancer_Homo sapiens_hsa052130.46716095
137Pathways in cancer_Homo sapiens_hsa052000.46252297
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45821075
139Graft-versus-host disease_Homo sapiens_hsa053320.44682410
140Butanoate metabolism_Homo sapiens_hsa006500.44553361
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44076139
142Sulfur relay system_Homo sapiens_hsa041220.43875980
143Peroxisome_Homo sapiens_hsa041460.43835873
144Wnt signaling pathway_Homo sapiens_hsa043100.43802549
145Vitamin digestion and absorption_Homo sapiens_hsa049770.43257906
146HIF-1 signaling pathway_Homo sapiens_hsa040660.39395656
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35202324
148Influenza A_Homo sapiens_hsa051640.34762661
149Other glycan degradation_Homo sapiens_hsa005110.34634074
150Tyrosine metabolism_Homo sapiens_hsa003500.33181710
151Autoimmune thyroid disease_Homo sapiens_hsa053200.32902396

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