DSTNP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.15763567
2negative regulation of cell killing (GO:0031342)5.31649675
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.31649675
4regulation of B cell receptor signaling pathway (GO:0050855)4.92436609
5regulation of gamma-delta T cell differentiation (GO:0045586)4.68076523
6negative T cell selection (GO:0043383)4.52534531
7regulation of gamma-delta T cell activation (GO:0046643)4.46653618
8negative thymic T cell selection (GO:0045060)4.35608673
9protein K11-linked deubiquitination (GO:0035871)4.23346648
10positive T cell selection (GO:0043368)4.22678028
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.20668324
12regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.14907807
13positive regulation of granulocyte differentiation (GO:0030854)3.99450569
14negative regulation of T cell mediated immunity (GO:0002710)3.91562370
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.87019745
16modulation by symbiont of host immune response (GO:0052553)3.87019745
17positive regulation by symbiont of host defense response (GO:0052509)3.87019745
18modulation by symbiont of host defense response (GO:0052031)3.87019745
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.87019745
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.87019745
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86578645
22activated T cell proliferation (GO:0050798)3.82347574
23phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.76556355
24CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.75119253
25T-helper cell differentiation (GO:0042093)3.75119253
26microglial cell activation (GO:0001774)3.72541083
27histone H3-K36 demethylation (GO:0070544)3.66588243
28tolerance induction (GO:0002507)3.59169867
29interferon-gamma production (GO:0032609)3.55377090
30leukocyte aggregation (GO:0070486)3.54915095
31positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.51685061
32mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.51685061
33positive thymic T cell selection (GO:0045059)3.49436965
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.41534148
35negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.41142382
36response to interleukin-15 (GO:0070672)3.39529426
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32704891
38alpha-beta T cell activation (GO:0046631)3.28795371
39negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.28784631
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28543126
41cellular response to interleukin-15 (GO:0071350)3.26773300
42alpha-beta T cell differentiation (GO:0046632)3.26618707
43detection of molecule of bacterial origin (GO:0032490)3.25064996
44alpha-beta T cell differentiation involved in immune response (GO:0002293)3.20906883
45alpha-beta T cell activation involved in immune response (GO:0002287)3.20906883
46T cell differentiation involved in immune response (GO:0002292)3.20906883
47natural killer cell activation involved in immune response (GO:0002323)3.20401430
48myeloid leukocyte mediated immunity (GO:0002444)3.20299559
49B cell receptor signaling pathway (GO:0050853)3.18692857
50neutrophil mediated immunity (GO:0002446)3.17347706
51T cell selection (GO:0045058)3.15427573
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05900062
53response to host immune response (GO:0052572)3.05900062
54regulation of germinal center formation (GO:0002634)3.04331475
55CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.04107555
56negative regulation of B cell proliferation (GO:0030889)3.03356364
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03301177
58negative regulation of monooxygenase activity (GO:0032769)3.02244821
59regulation of regulatory T cell differentiation (GO:0045589)2.98296438
60T cell migration (GO:0072678)2.96065522
61B cell proliferation (GO:0042100)2.93802718
62protein targeting to vacuole (GO:0006623)2.92399425
63protein targeting to lysosome (GO:0006622)2.92399425
64establishment of protein localization to vacuole (GO:0072666)2.92399425
65negative regulation of adaptive immune response (GO:0002820)2.92238082
66antigen processing and presentation of endogenous antigen (GO:0019883)2.91284708
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90117203
68histone H3-K4 trimethylation (GO:0080182)2.89627955
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89430246
70response to host (GO:0075136)2.89430246
71response to host defenses (GO:0052200)2.89430246
72establishment of protein localization to Golgi (GO:0072600)2.86252059
73neural tube formation (GO:0001841)2.85923682
74macrophage activation involved in immune response (GO:0002281)2.83984525
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83158641
76negative regulation of T-helper cell differentiation (GO:0045623)2.83158641
77protein targeting to Golgi (GO:0000042)2.82194982
78hepatocyte apoptotic process (GO:0097284)2.81234670
79regulation of MHC class I biosynthetic process (GO:0045343)2.75401804
80histone mRNA catabolic process (GO:0071044)2.74579227
81retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73255119
82negative regulation of nitric-oxide synthase activity (GO:0051001)2.72233361
83CD4-positive, alpha-beta T cell activation (GO:0035710)2.71860257
84regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.71725913
85negative regulation of B cell mediated immunity (GO:0002713)2.70406756
86negative regulation of immunoglobulin mediated immune response (GO:0002890)2.70406756
87negative regulation of mast cell activation (GO:0033004)2.69559007
88regulation of interferon-beta biosynthetic process (GO:0045357)2.69059531
89regulation of alpha-beta T cell proliferation (GO:0046640)2.68766324
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.68686015
91regulation of natural killer cell mediated immunity (GO:0002715)2.68686015
92positive regulation of natural killer cell mediated immunity (GO:0002717)2.67539538
93negative regulation of interleukin-12 production (GO:0032695)2.67030745
94T cell activation involved in immune response (GO:0002286)2.66923295
95T cell receptor signaling pathway (GO:0050852)2.66442504
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64285373
97necrotic cell death (GO:0070265)2.63376545
98T cell proliferation (GO:0042098)2.61437107
99macrophage activation (GO:0042116)2.60314375
100negative regulation of protein autophosphorylation (GO:0031953)2.60201154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.43929536
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.03365399
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.39175782
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.02013762
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.00687221
6RUNX_20019798_ChIP-Seq_JUKART_Human2.88333559
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53973040
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50016219
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49391149
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46341297
11IGF1R_20145208_ChIP-Seq_DFB_Human2.39317843
12MYB_26560356_Chip-Seq_TH2_Human2.28659697
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21868278
14SCL_19346495_ChIP-Seq_HPC-7_Human2.21737752
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15196125
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11926463
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00232608
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.99451235
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93647657
20GATA3_27048872_Chip-Seq_THYMUS_Human1.88829656
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.82145438
22MYB_26560356_Chip-Seq_TH1_Human1.82026659
23GATA3_26560356_Chip-Seq_TH2_Human1.81803281
24VDR_24787735_ChIP-Seq_THP-1_Human1.68617626
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.65434270
26ER_23166858_ChIP-Seq_MCF-7_Human1.63235214
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62930676
28AR_21572438_ChIP-Seq_LNCaP_Human1.60351517
29ZNF274_21170338_ChIP-Seq_K562_Hela1.58681846
30SPI1_23547873_ChIP-Seq_NB4_Human1.55977884
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51163743
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50954389
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48656730
34TAF15_26573619_Chip-Seq_HEK293_Human1.47359240
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45748988
36SPI1_23127762_ChIP-Seq_K562_Human1.44428156
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43770723
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41660250
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40319720
40GBX2_23144817_ChIP-Seq_PC3_Human1.38631933
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38187680
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.38033496
43CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37248352
44PRDM14_20953172_ChIP-Seq_ESCs_Human1.36945603
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36018087
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33665394
47FUS_26573619_Chip-Seq_HEK293_Human1.32406103
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32218317
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.31216539
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28836147
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28651920
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24214303
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.22839538
54FLI1_21867929_ChIP-Seq_TH2_Mouse1.21896691
55GATA1_22025678_ChIP-Seq_K562_Human1.21355902
56STAT3_23295773_ChIP-Seq_U87_Human1.19831126
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19250451
58SMRT_27268052_Chip-Seq_Bcells_Human1.17452520
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.15891206
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15561193
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14127261
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12189612
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11853049
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10746121
65P300_19829295_ChIP-Seq_ESCs_Human1.10090922
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08665451
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06536279
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06497744
69KDM2B_26808549_Chip-Seq_REH_Human1.06471350
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05676650
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.05008541
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04206812
73TCF4_23295773_ChIP-Seq_U87_Human1.04096621
74SMAD4_21799915_ChIP-Seq_A2780_Human1.04035417
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03282785
76CBP_20019798_ChIP-Seq_JUKART_Human1.02883444
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02883444
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01553798
79PU_27001747_Chip-Seq_BMDM_Mouse1.01001494
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99310632
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99254997
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98425692
83CIITA_25753668_ChIP-Seq_RAJI_Human0.98263111
84GATA2_21666600_ChIP-Seq_HMVEC_Human0.98028213
85UTX_26944678_Chip-Seq_JUKART_Human0.97610437
86CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96407888
87BCAT_22108803_ChIP-Seq_LS180_Human0.95519289
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95361738
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93347426
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92874132
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90938043
92CMYC_18555785_Chip-Seq_ESCs_Mouse0.90468602
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90083116
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89974117
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88289994
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87068121
97KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86732094
98P53_22387025_ChIP-Seq_ESCs_Mouse0.85585166
99GATA3_26560356_Chip-Seq_TH1_Human0.85387978
100MAF_26560356_Chip-Seq_TH1_Human0.84547881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.30781397
2MP0003724_increased_susceptibility_to3.60608844
3MP0000372_irregular_coat_pigmentation3.39633107
4MP0003787_abnormal_imprinting3.29565523
5MP0005075_abnormal_melanosome_morpholog3.28960624
6MP0002822_catalepsy3.05584931
7MP0004381_abnormal_hair_follicle3.03130099
8MP0003763_abnormal_thymus_physiology2.95694077
9MP0001835_abnormal_antigen_presentation2.46978691
10MP0008260_abnormal_autophagy2.40277173
11MP0008877_abnormal_DNA_methylation2.39911965
12MP0005671_abnormal_response_to2.38854168
13MP0002638_abnormal_pupillary_reflex2.25838329
14MP0001800_abnormal_humoral_immune2.22359584
15MP0005174_abnormal_tail_pigmentation2.13834074
16MP0002723_abnormal_immune_serum1.99984514
17MP0005000_abnormal_immune_tolerance1.94096824
18MP0000015_abnormal_ear_pigmentation1.92322795
19MP0002420_abnormal_adaptive_immunity1.91055252
20MP0009785_altered_susceptibility_to1.90797896
21MP0001819_abnormal_immune_cell1.90769334
22MP0008057_abnormal_DNA_replication1.88119299
23MP0000465_gastrointestinal_hemorrhage1.82126452
24MP0003436_decreased_susceptibility_to1.81881346
25MP0000371_diluted_coat_color1.80792758
26MP0005025_abnormal_response_to1.79931430
27MP0000703_abnormal_thymus_morphology1.78535281
28MP0002419_abnormal_innate_immunity1.78198214
29MP0005310_abnormal_salivary_gland1.75519959
30MP0003172_abnormal_lysosome_physiology1.74945987
31MP0002398_abnormal_bone_marrow1.74912127
32MP0002452_abnormal_antigen_presenting1.72879814
33MP0000689_abnormal_spleen_morphology1.63601106
34MP0004883_abnormal_blood_vessel1.61423047
35MP0000716_abnormal_immune_system1.61108088
36MP0000685_abnormal_immune_system1.60794197
37MP0002166_altered_tumor_susceptibility1.60174826
38MP0003303_peritoneal_inflammation1.55411608
39MP0003656_abnormal_erythrocyte_physiolo1.52815280
40MP0002722_abnormal_immune_system1.47859600
41MP0002405_respiratory_system_inflammati1.42522366
42MP0003866_abnormal_defecation1.40253250
43MP0006054_spinal_hemorrhage1.40000280
44MP0002332_abnormal_exercise_endurance1.39322105
45MP0004134_abnormal_chest_morphology1.36872769
46MP0002396_abnormal_hematopoietic_system1.36462850
47MP0002102_abnormal_ear_morphology1.34423868
48MP0001790_abnormal_immune_system1.28884507
49MP0005387_immune_system_phenotype1.28884507
50MP0005408_hypopigmentation1.28693281
51MP0003221_abnormal_cardiomyocyte_apopto1.24261550
52MP0004130_abnormal_muscle_cell1.23186604
53MP0003646_muscle_fatigue1.22181594
54MP0002429_abnormal_blood_cell1.21240546
55MP0001845_abnormal_inflammatory_respons1.19152677
56MP0003828_pulmonary_edema1.11667568
57MP0000427_abnormal_hair_cycle1.09156980
58MP0003191_abnormal_cellular_cholesterol1.08609981
59MP0004142_abnormal_muscle_tone1.07703920
60MP0005171_absent_coat_pigmentation1.07634022
61MP0004484_altered_response_of1.02822396
62MP0002095_abnormal_skin_pigmentation1.01664458
63MP0005464_abnormal_platelet_physiology1.01362292
64MP0002277_abnormal_respiratory_mucosa0.99918922
65MP0001851_eye_inflammation0.97930780
66MP0002075_abnormal_coat/hair_pigmentati0.96751619
67MP0002006_tumorigenesis0.94488364
68MP0004043_abnormal_pH_regulation0.94422515
69MP0002009_preneoplasia0.92664492
70MP0003195_calcinosis0.91928353
71MP0004947_skin_inflammation0.88453032
72MP0003950_abnormal_plasma_membrane0.88349538
73MP0009764_decreased_sensitivity_to0.87961381
74MP0005266_abnormal_metabolism0.87949082
75MP0002148_abnormal_hypersensitivity_rea0.85971753
76MP0003300_gastrointestinal_ulcer0.85063313
77MP0003183_abnormal_peptide_metabolism0.84730847
78MP0001533_abnormal_skeleton_physiology0.84158711
79MP0006082_CNS_inflammation0.84154198
80MP0003121_genomic_imprinting0.78803299
81MP0001186_pigmentation_phenotype0.78766836
82MP0002909_abnormal_adrenal_gland0.72570002
83MP0002933_joint_inflammation0.72388138
84MP0005376_homeostasis/metabolism_phenot0.71403725
85MP0005551_abnormal_eye_electrophysiolog0.70074951
86MP0008961_abnormal_basal_metabolism0.69412044
87MP0009333_abnormal_splenocyte_physiolog0.68384338
88MP0003279_aneurysm0.67885443
89MP0001905_abnormal_dopamine_level0.67321648
90MP0002693_abnormal_pancreas_physiology0.66179353
91MP0009115_abnormal_fat_cell0.65337579
92MP0009765_abnormal_xenobiotic_induced0.64687771
93MP0009763_increased_sensitivity_to0.64571622
94MP0009780_abnormal_chondrocyte_physiolo0.64473051
95MP0004808_abnormal_hematopoietic_stem0.62705829
96MP0002132_abnormal_respiratory_system0.62037628
97MP0005164_abnormal_response_to0.59475144
98MP0002998_abnormal_bone_remodeling0.59044092
99MP0001915_intracranial_hemorrhage0.58688012
100MP0002735_abnormal_chemical_nociception0.58033739

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.53799362
2Abnormality of T cell number (HP:0011839)5.01927220
3Recurrent bacterial skin infections (HP:0005406)4.17412325
4Recurrent abscess formation (HP:0002722)4.07142456
5Severe combined immunodeficiency (HP:0004430)3.87097246
6Stomatitis (HP:0010280)3.73612780
7Thyroiditis (HP:0100646)3.67428024
8Eczematoid dermatitis (HP:0000976)3.65486256
9Spontaneous hematomas (HP:0007420)3.51705863
10Recurrent fungal infections (HP:0002841)3.46925089
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.46115619
12IgG deficiency (HP:0004315)3.41440516
13Abnormality of eosinophils (HP:0001879)3.36317510
14Retrobulbar optic neuritis (HP:0100654)3.26851733
15Optic neuritis (HP:0100653)3.26851733
16Ketoacidosis (HP:0001993)3.20400102
17Eosinophilia (HP:0001880)3.13332422
18Leukocytosis (HP:0001974)3.12629718
19Abnormality of T cells (HP:0002843)3.09341592
20Abnormal hair whorl (HP:0010721)3.07503995
21Combined immunodeficiency (HP:0005387)3.05462803
22Abnormal delayed hypersensitivity skin test (HP:0002963)2.91730267
23Myositis (HP:0100614)2.91132303
24Abnormality of the pancreatic islet cells (HP:0006476)2.90073256
25Abnormality of endocrine pancreas physiology (HP:0012093)2.90073256
26Visual hallucinations (HP:0002367)2.89340932
27Bilateral sensorineural hearing impairment (HP:0008619)2.88979070
28Orchitis (HP:0100796)2.80396733
29Recurrent cutaneous fungal infections (HP:0011370)2.73991003
30Chronic mucocutaneous candidiasis (HP:0002728)2.73991003
31Granulocytopenia (HP:0001913)2.67718241
32Panhypogammaglobulinemia (HP:0003139)2.67520261
33Recurrent skin infections (HP:0001581)2.67416201
34Macroorchidism (HP:0000053)2.67342000
35Acute hepatic failure (HP:0006554)2.64907978
36Agitation (HP:0000713)2.61050810
37Encephalitis (HP:0002383)2.58856160
38Gingivitis (HP:0000230)2.58778157
39Pustule (HP:0200039)2.49212642
40Congenital stationary night blindness (HP:0007642)2.44097938
41Hemiplegia (HP:0002301)2.43017475
42Truncal obesity (HP:0001956)2.39581052
43Stomach cancer (HP:0012126)2.38009508
44Gastrointestinal infarctions (HP:0005244)2.32757696
45Recurrent viral infections (HP:0004429)2.31666670
46Keratoconjunctivitis sicca (HP:0001097)2.30217828
47Hematochezia (HP:0002573)2.29081575
48Elevated erythrocyte sedimentation rate (HP:0003565)2.26076506
49Resting tremor (HP:0002322)2.25571094
50Ocular albinism (HP:0001107)2.24454768
51Gaze-evoked nystagmus (HP:0000640)2.24373214
52Long foot (HP:0001833)2.23354393
53Gingival bleeding (HP:0000225)2.22605055
54Hypoplasia of the thymus (HP:0000778)2.21501331
55Keratoconjunctivitis (HP:0001096)2.21226246
56Genetic anticipation (HP:0003743)2.11469554
57Papillary thyroid carcinoma (HP:0002895)2.10771965
58Progressive cerebellar ataxia (HP:0002073)2.03777455
59Mediastinal lymphadenopathy (HP:0100721)2.01961941
60Medial flaring of the eyebrow (HP:0010747)2.00238061
61Iris hypopigmentation (HP:0007730)2.00009866
62Autoimmune hemolytic anemia (HP:0001890)1.99299433
63Aplasia/Hypoplasia of the macula (HP:0008059)1.97310462
64Poor coordination (HP:0002370)1.97217926
65Congenital primary aphakia (HP:0007707)1.93400246
66Glucose intolerance (HP:0000833)1.93111313
67Abnormality of macrophages (HP:0004311)1.92868671
68Renal cortical cysts (HP:0000803)1.92366671
69Meningitis (HP:0001287)1.91515651
70Porencephaly (HP:0002132)1.91270042
71Neoplasm of the heart (HP:0100544)1.90582937
72Postural instability (HP:0002172)1.88449368
73Lymphopenia (HP:0001888)1.87978215
74Abnormality of B cell number (HP:0010975)1.87869989
75Hemoptysis (HP:0002105)1.87558687
76Absent speech (HP:0001344)1.86786211
77Increased IgM level (HP:0003496)1.86447500
78Neurodegeneration (HP:0002180)1.86381683
79Recurrent gram-negative bacterial infections (HP:0005420)1.86334459
80Gait imbalance (HP:0002141)1.83592968
81Generalized hypopigmentation (HP:0007513)1.83574867
82Ketosis (HP:0001946)1.82327907
83Methylmalonic acidemia (HP:0002912)1.82325430
84Spinal muscular atrophy (HP:0007269)1.80379637
85Subacute progressive viral hepatitis (HP:0006572)1.80035654
86Amyotrophic lateral sclerosis (HP:0007354)1.79100929
87Abnormal rod and cone electroretinograms (HP:0008323)1.77381297
88Prolonged bleeding time (HP:0003010)1.77379851
89IgA deficiency (HP:0002720)1.77324864
90Sepsis (HP:0100806)1.75820955
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75465694
92Volvulus (HP:0002580)1.75227826
93Conjunctival telangiectasia (HP:0000524)1.74580441
94Chest pain (HP:0100749)1.73874631
95Abnormality of the columella (HP:0009929)1.73382699
96Aplasia/Hypoplasia affecting the retina (HP:0008061)1.73000701
97Nephrogenic diabetes insipidus (HP:0009806)1.72543086
98Vasculitis (HP:0002633)1.71974390
99Broad ribs (HP:0000885)1.71607407
100Abnormality of T cell physiology (HP:0011840)1.70681490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.93216737
2TXK3.73738803
3MAP4K23.50229349
4FRK2.99227766
5IKBKE2.86994751
6GRK62.85256057
7PINK12.50290414
8FES2.42043326
9FGR2.18887661
10MAP4K11.97278783
11CAMKK21.93290468
12BLK1.82578115
13MARK31.82570160
14TYK21.75387338
15CSK1.67844024
16INSRR1.61801093
17NLK1.57518089
18SYK1.53709101
19MAP3K141.48677313
20SIK31.48388986
21JAK11.46891471
22JAK31.44374554
23TEC1.44283661
24SIK21.40572113
25MAPK131.38556838
26FGFR31.37175235
27ITK1.31545241
28HCK1.30024529
29NUAK11.28801055
30LCK1.26769104
31PASK1.26463609
32LYN1.25867444
33BTK1.23734259
34IRAK41.23524865
35ZAP701.23227556
36RIPK41.21161521
37PTK2B1.20928108
38PRKD21.07463644
39EPHA31.04625414
40TRPM71.01941023
41WNK11.01008739
42STK101.00161927
43PAK30.99056772
44ERBB30.97487854
45PLK20.96660280
46SGK20.94890683
47GRK70.91379559
48NEK60.91113802
49STK110.90666052
50MAP3K100.89001723
51GRK50.85438406
52ADRBK20.84582655
53CAMK40.82496656
54BMPR1B0.81920008
55PIM10.81564362
56TGFBR20.81534783
57MAP3K40.81251765
58EGFR0.76285057
59KIT0.76116092
60IKBKB0.74713898
61CDK60.74360575
62RPS6KA40.73722976
63TAOK10.73432445
64STK40.73048307
65PRKCQ0.71939984
66MARK20.70354486
67STK380.70086651
68FGFR20.68799338
69EPHB10.67389399
70YES10.66703988
71EIF2AK10.66094775
72CCNB10.64770232
73HIPK20.64510303
74IRAK10.61426375
75MATK0.60514621
76MELK0.60161436
77DAPK20.59857908
78CSF1R0.59728309
79PIK3CG0.59209759
80BMPR20.58576315
81DYRK1A0.57234435
82CDK40.56771520
83ERBB20.55349802
84CLK10.53512162
85DYRK1B0.52937439
86CAMKK10.52804733
87MAP3K70.52644125
88MAPKAPK30.51767815
89MAP2K30.50389000
90MAP3K50.50348318
91FYN0.48176085
92PRKCZ0.47546698
93JAK20.46327375
94CSNK1D0.45564546
95PRKAA20.45554796
96SGK30.45401743
97TBK10.43780611
98CHUK0.43054736
99FGFR40.42119574
100KSR10.38775940

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.08474101
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.49331599
3T cell receptor signaling pathway_Homo sapiens_hsa046602.25817634
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.17651417
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.13938738
6Measles_Homo sapiens_hsa051622.06320826
7Osteoclast differentiation_Homo sapiens_hsa043801.93057007
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92465147
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90536285
10B cell receptor signaling pathway_Homo sapiens_hsa046621.73301954
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60870858
12Jak-STAT signaling pathway_Homo sapiens_hsa046301.55671251
13Hematopoietic cell lineage_Homo sapiens_hsa046401.53577533
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49881011
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48259325
16Leishmaniasis_Homo sapiens_hsa051401.48042725
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43615621
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41696685
19Non-small cell lung cancer_Homo sapiens_hsa052231.41260333
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39328441
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38137864
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.34226609
23Chemokine signaling pathway_Homo sapiens_hsa040621.32580291
24Tuberculosis_Homo sapiens_hsa051521.29625059
25Hepatitis B_Homo sapiens_hsa051611.26870908
26FoxO signaling pathway_Homo sapiens_hsa040681.23852527
27Herpes simplex infection_Homo sapiens_hsa051681.23598292
28Shigellosis_Homo sapiens_hsa051311.21155093
29Phototransduction_Homo sapiens_hsa047441.18305289
30TNF signaling pathway_Homo sapiens_hsa046681.15508186
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15202343
32Morphine addiction_Homo sapiens_hsa050321.14336610
33Platelet activation_Homo sapiens_hsa046111.09386489
34Type II diabetes mellitus_Homo sapiens_hsa049301.08025027
35Legionellosis_Homo sapiens_hsa051341.07195351
36Dorso-ventral axis formation_Homo sapiens_hsa043201.04935497
37Hepatitis C_Homo sapiens_hsa051601.02793286
38mTOR signaling pathway_Homo sapiens_hsa041501.02280046
39Acute myeloid leukemia_Homo sapiens_hsa052210.99727034
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97846219
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97823227
42Malaria_Homo sapiens_hsa051440.96602751
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.96218432
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.95686100
45Regulation of autophagy_Homo sapiens_hsa041400.95105716
46Sphingolipid signaling pathway_Homo sapiens_hsa040710.93025431
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92546932
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92465634
49Ras signaling pathway_Homo sapiens_hsa040140.92336066
50Pancreatic cancer_Homo sapiens_hsa052120.84988183
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84562712
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84068144
53Influenza A_Homo sapiens_hsa051640.83215923
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80658509
55Endometrial cancer_Homo sapiens_hsa052130.80657810
56Prostate cancer_Homo sapiens_hsa052150.78618551
57Prolactin signaling pathway_Homo sapiens_hsa049170.78550716
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78296009
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77469868
60Inositol phosphate metabolism_Homo sapiens_hsa005620.76704000
61Ether lipid metabolism_Homo sapiens_hsa005650.74139819
62Apoptosis_Homo sapiens_hsa042100.73694618
63Toxoplasmosis_Homo sapiens_hsa051450.73636781
64Viral carcinogenesis_Homo sapiens_hsa052030.68497594
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.67932982
66Non-homologous end-joining_Homo sapiens_hsa034500.67644478
67Selenocompound metabolism_Homo sapiens_hsa004500.65792099
68MAPK signaling pathway_Homo sapiens_hsa040100.63218925
69Insulin resistance_Homo sapiens_hsa049310.61982494
70Colorectal cancer_Homo sapiens_hsa052100.61082651
71Choline metabolism in cancer_Homo sapiens_hsa052310.61043839
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60797644
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60423045
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59839638
75Long-term depression_Homo sapiens_hsa047300.59447278
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58805191
77Endocytosis_Homo sapiens_hsa041440.58761421
78Sphingolipid metabolism_Homo sapiens_hsa006000.58001116
79Cholinergic synapse_Homo sapiens_hsa047250.57752049
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56442690
81Rap1 signaling pathway_Homo sapiens_hsa040150.56207313
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.55809862
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.55754276
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54826065
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53573242
86Renal cell carcinoma_Homo sapiens_hsa052110.53148155
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52288428
88Viral myocarditis_Homo sapiens_hsa054160.51799594
89Epstein-Barr virus infection_Homo sapiens_hsa051690.51738114
90Staphylococcus aureus infection_Homo sapiens_hsa051500.50874200
91Glioma_Homo sapiens_hsa052140.50544577
92Renin secretion_Homo sapiens_hsa049240.49675800
93Phagosome_Homo sapiens_hsa041450.49635639
94Type I diabetes mellitus_Homo sapiens_hsa049400.49256929
95Graft-versus-host disease_Homo sapiens_hsa053320.48984652
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47455047
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46664662
98Nicotine addiction_Homo sapiens_hsa050330.46603323
99Chronic myeloid leukemia_Homo sapiens_hsa052200.46070420
100Melanoma_Homo sapiens_hsa052180.44660146

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