ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.58442827
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.79888976
3	protein complex biogenesis (GO:0070271)	4.14276782
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.97655179
5	ATP synthesis coupled proton transport (GO:0015986)	3.97655179
6	protein neddylation (GO:0045116)	3.95124553
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.94681099
8	DNA deamination (GO:0045006)	3.93369072
9	mitochondrial respiratory chain complex assembly (GO:0033108)	3.88763607
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.86375769
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.86375769
12	NADH dehydrogenase complex assembly (GO:0010257)	3.86375769
13	protein-cofactor linkage (GO:0018065)	3.69953300
14	platelet dense granule organization (GO:0060155)	3.66637964
15	regulation of cilium movement (GO:0003352)	3.48226663
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.45488909
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.44075586
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.39241047
19	nonmotile primary cilium assembly (GO:0035058)	3.33479945
20	neuronal action potential (GO:0019228)	3.33394443
21	respiratory chain complex IV assembly (GO:0008535)	3.27031107
22	behavioral response to ethanol (GO:0048149)	3.23270565
23	epithelial cilium movement (GO:0003351)	3.22459910
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.21914371
25	L-fucose catabolic process (GO:0042355)	3.20451442
26	fucose catabolic process (GO:0019317)	3.20451442
27	L-fucose metabolic process (GO:0042354)	3.20451442
28	regulation of hexokinase activity (GO:1903299)	3.19199787
29	regulation of glucokinase activity (GO:0033131)	3.19199787
30	cellular ketone body metabolic process (GO:0046950)	3.17707495
31	ubiquinone biosynthetic process (GO:0006744)	3.15682147
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.10089757
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.10089757
34	cytochrome complex assembly (GO:0017004)	3.08384619
35	kynurenine metabolic process (GO:0070189)	3.06933972
36	electron transport chain (GO:0022900)	3.06586412
37	somite rostral/caudal axis specification (GO:0032525)	3.01724754
38	kidney morphogenesis (GO:0060993)	3.01473944
39	respiratory electron transport chain (GO:0022904)	3.00104880
40	regulation of action potential (GO:0098900)	2.96818737
41	indole-containing compound catabolic process (GO:0042436)	2.96263626
42	indolalkylamine catabolic process (GO:0046218)	2.96263626
43	tryptophan catabolic process (GO:0006569)	2.96263626
44	ubiquinone metabolic process (GO:0006743)	2.92984413
45	intracellular protein transmembrane import (GO:0044743)	2.90398457
46	indolalkylamine metabolic process (GO:0006586)	2.89967847
47	piRNA metabolic process (GO:0034587)	2.89718923
48	detection of light stimulus involved in sensory perception (GO:0050962)	2.89526092
49	detection of light stimulus involved in visual perception (GO:0050908)	2.89526092
50	ketone body metabolic process (GO:1902224)	2.86858926
51	hydrogen ion transmembrane transport (GO:1902600)	2.84474441
52	protein localization to cilium (GO:0061512)	2.82074500
53	positive regulation of action potential (GO:0045760)	2.81967196
54	response to pheromone (GO:0019236)	2.81230232
55	regulation of meiosis I (GO:0060631)	2.80525310
56	negative regulation of telomere maintenance (GO:0032205)	2.75437353
57	preassembly of GPI anchor in ER membrane (GO:0016254)	2.74323780
58	proton transport (GO:0015992)	2.72531240
59	protein polyglutamylation (GO:0018095)	2.72161268
60	amine catabolic process (GO:0009310)	2.71447741
61	cellular biogenic amine catabolic process (GO:0042402)	2.71447741
62	synaptic transmission, cholinergic (GO:0007271)	2.71279984
63	sequestering of actin monomers (GO:0042989)	2.71072255
64	gamma-aminobutyric acid transport (GO:0015812)	2.68854242
65	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.68320594
66	dopamine transport (GO:0015872)	2.68216400
67	hydrogen transport (GO:0006818)	2.67528394
68	positive regulation of gastrulation (GO:2000543)	2.67406049
69	cilium morphogenesis (GO:0060271)	2.67336697
70	regulation of microtubule-based movement (GO:0060632)	2.64650152
71	proteasome assembly (GO:0043248)	2.62299283
72	protein K6-linked ubiquitination (GO:0085020)	2.61123464
73	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.60627805
74	retinal cone cell development (GO:0046549)	2.57369486
75	replication fork processing (GO:0031297)	2.56322527
76	axoneme assembly (GO:0035082)	2.54903955
77	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.54123307
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.54048759
79	positive regulation of meiosis (GO:0045836)	2.52841286
80	sulfation (GO:0051923)	2.51293818
81	nephron epithelium morphogenesis (GO:0072088)	2.50744336
82	nephron tubule morphogenesis (GO:0072078)	2.50744336
83	cilium organization (GO:0044782)	2.50676145
84	tryptophan metabolic process (GO:0006568)	2.50466391
85	reflex (GO:0060004)	2.49722239
86	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.47619958
87	cilium movement (GO:0003341)	2.47202343
88	recombinational repair (GO:0000725)	2.46578021
89	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.44414000
90	positive regulation of fatty acid transport (GO:2000193)	2.44154811
91	cilium assembly (GO:0042384)	2.43908388
92	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.43535331
93	neural tube formation (GO:0001841)	2.43427890
94	mannosylation (GO:0097502)	2.42539863
95	double-strand break repair via homologous recombination (GO:0000724)	2.42539542
96	negative regulation of mast cell activation (GO:0033004)	2.41097290
97	tRNA processing (GO:0008033)	2.40813751
98	quinone biosynthetic process (GO:1901663)	2.38726781
99	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.38417008
100	synapsis (GO:0007129)	2.37677099

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.03824295
2	VDR_22108803_ChIP-Seq_LS180_Human	3.38508975
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.22598073
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.83832119
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50878437
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.49047149
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.45726149
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.45719898
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.43471981
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.25522923
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.24534978
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19794215
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18199217
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16821071
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11600750
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11262401
17	EWS_26573619_Chip-Seq_HEK293_Human	2.10505315
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.08176465
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.08141605
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.07419671
21	P300_19829295_ChIP-Seq_ESCs_Human	2.02622316
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.87214251
23	FUS_26573619_Chip-Seq_HEK293_Human	1.87017639
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83174547
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.74659404
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74290629
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74085787
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.69263415
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66456248
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.65909118
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.65192854
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63510153
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57823419
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.56767326
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.56215965
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55456722
37	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52193256
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46351199
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.45383134
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.41172473
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.39258742
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36593302
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36160269
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.35506081
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35506081
46	AR_25329375_ChIP-Seq_VCAP_Human	1.34991726
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34543423
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32551874
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32208216
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32208216
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29129085
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29129085
53	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28430262
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27734020
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26888974
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26870777
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26265037
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26265037
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23902342
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22656474
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22590488
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22238593
63	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.22205265
64	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20471024
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20416433
66	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19213304
67	STAT3_23295773_ChIP-Seq_U87_Human	1.18736544
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17459372
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17169096
70	AR_20517297_ChIP-Seq_VCAP_Human	1.16133624
71	HTT_18923047_ChIP-ChIP_STHdh_Human	1.15794971
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15736730
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.14981451
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14320247
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12676626
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12534869
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12494630
78	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.12107749
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11008692
80	TCF4_23295773_ChIP-Seq_U87_Human	1.10774309
81	NCOR_22424771_ChIP-Seq_293T_Human	1.09866842
82	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08260439
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07457093
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07152300
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05176440
86	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.05104157
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03404065
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03270622
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02626857
90	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02551247
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01249192
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99798506
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98568305
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97766966
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97443367
96	JUN_21703547_ChIP-Seq_K562_Human	0.96532796
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96368204
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96137989
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95733595
100	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94328583

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.02887525
2	MP0002837_dystrophic_cardiac_calcinosis	3.01628789
3	MP0002102_abnormal_ear_morphology	2.86965302
4	MP0003195_calcinosis	2.64530441
5	MP0005084_abnormal_gallbladder_morpholo	2.62640586
6	MP0003136_yellow_coat_color	2.61983456
7	MP0000569_abnormal_digit_pigmentation	2.58887532
8	MP0003787_abnormal_imprinting	2.39344863
9	MP0005551_abnormal_eye_electrophysiolog	2.24713134
10	MP0001968_abnormal_touch/_nociception	2.06741670
11	MP0004133_heterotaxia	2.03034204
12	MP0004147_increased_porphyrin_level	2.02829674
13	MP0004142_abnormal_muscle_tone	1.91968654
14	MP0004885_abnormal_endolymph	1.89537790
15	MP0006072_abnormal_retinal_apoptosis	1.89423894
16	MP0003283_abnormal_digestive_organ	1.88892803
17	MP0002653_abnormal_ependyma_morphology	1.88759511
18	MP0005645_abnormal_hypothalamus_physiol	1.85643555
19	MP0000372_irregular_coat_pigmentation	1.83800932
20	MP0009745_abnormal_behavioral_response	1.80614035
21	MP0002638_abnormal_pupillary_reflex	1.79759947
22	MP0006292_abnormal_olfactory_placode	1.78555887
23	MP0001529_abnormal_vocalization	1.77483991
24	MP0003011_delayed_dark_adaptation	1.76130360
25	MP0009046_muscle_twitch	1.73699402
26	MP0002736_abnormal_nociception_after	1.73025926
27	MP0008872_abnormal_physiological_respon	1.70494828
28	MP0008875_abnormal_xenobiotic_pharmacok	1.70156670
29	MP0002938_white_spotting	1.68055348
30	MP0002733_abnormal_thermal_nociception	1.62238459
31	MP0005174_abnormal_tail_pigmentation	1.62225735
32	MP0001485_abnormal_pinna_reflex	1.58974977
33	MP0009379_abnormal_foot_pigmentation	1.53573296
34	MP0002272_abnormal_nervous_system	1.53086615
35	MP0002277_abnormal_respiratory_mucosa	1.52285601
36	MP0003880_abnormal_central_pattern	1.51529975
37	MP0003122_maternal_imprinting	1.51200481
38	MP0005646_abnormal_pituitary_gland	1.48228209
39	MP0003646_muscle_fatigue	1.47784701
40	MP0006276_abnormal_autonomic_nervous	1.47254519
41	MP0002876_abnormal_thyroid_physiology	1.44981511
42	MP0005253_abnormal_eye_physiology	1.43767571
43	MP0002163_abnormal_gland_morphology	1.42178953
44	MP0002735_abnormal_chemical_nociception	1.42074201
45	MP0004742_abnormal_vestibular_system	1.42057277
46	MP0002928_abnormal_bile_duct	1.40085137
47	MP0001970_abnormal_pain_threshold	1.39131778
48	MP0001905_abnormal_dopamine_level	1.38273155
49	MP0002064_seizures	1.34151102
50	MP0003890_abnormal_embryonic-extraembry	1.33020948
51	MP0003121_genomic_imprinting	1.32262750
52	MP0002572_abnormal_emotion/affect_behav	1.29316289
53	MP0001188_hyperpigmentation	1.29096581
54	MP0000427_abnormal_hair_cycle	1.28101973
55	MP0000631_abnormal_neuroendocrine_gland	1.26402591
56	MP0001486_abnormal_startle_reflex	1.26227552
57	MP0001986_abnormal_taste_sensitivity	1.25783501
58	MP0001984_abnormal_olfaction	1.24418382
59	MP0004043_abnormal_pH_regulation	1.22021165
60	MP0004145_abnormal_muscle_electrophysio	1.21502781
61	MP0005379_endocrine/exocrine_gland_phen	1.20389836
62	MP0003806_abnormal_nucleotide_metabolis	1.19024875
63	MP0002095_abnormal_skin_pigmentation	1.15833590
64	MP0002557_abnormal_social/conspecific_i	1.14474097
65	MP0002067_abnormal_sensory_capabilities	1.12367134
66	MP0002909_abnormal_adrenal_gland	1.08641366
67	MP0005167_abnormal_blood-brain_barrier	1.04921220
68	MP0002734_abnormal_mechanical_nocicepti	1.03983672
69	MP0005195_abnormal_posterior_eye	0.99712962
70	MP0002693_abnormal_pancreas_physiology	0.97837478
71	MP0008058_abnormal_DNA_repair	0.96968474
72	MP0005332_abnormal_amino_acid	0.95999638
73	MP0000026_abnormal_inner_ear	0.94501466
74	MP0000647_abnormal_sebaceous_gland	0.91733883
75	MP0001873_stomach_inflammation	0.91599340
76	MP0005410_abnormal_fertilization	0.91000141
77	MP0003119_abnormal_digestive_system	0.90918374
78	MP0004924_abnormal_behavior	0.90295646
79	MP0005386_behavior/neurological_phenoty	0.90295646
80	MP0003718_maternal_effect	0.90225950
81	MP0003635_abnormal_synaptic_transmissio	0.89429437
82	MP0000778_abnormal_nervous_system	0.88698018
83	MP0001501_abnormal_sleep_pattern	0.88480165
84	MP0010386_abnormal_urinary_bladder	0.88267483
85	MP0004215_abnormal_myocardial_fiber	0.88067160
86	MP0002751_abnormal_autonomic_nervous	0.87642860
87	MP0002160_abnormal_reproductive_system	0.86775342
88	MP0002063_abnormal_learning/memory/cond	0.86151486
89	MP0008995_early_reproductive_senescence	0.85847565
90	MP0005389_reproductive_system_phenotype	0.84942922
91	MP0000230_abnormal_systemic_arterial	0.82636567
92	MP0002229_neurodegeneration	0.80924443
93	MP0002752_abnormal_somatic_nervous	0.80057783
94	MP0003698_abnormal_male_reproductive	0.78903665
95	MP0009764_decreased_sensitivity_to	0.78779168
96	MP0002210_abnormal_sex_determination	0.78730491
97	MP0003186_abnormal_redox_activity	0.78002293
98	MP0001293_anophthalmia	0.78002045
99	MP0000383_abnormal_hair_follicle	0.77967777
100	MP0001324_abnormal_eye_pigmentation	0.77958357

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.39598711
2	Abnormality of midbrain morphology (HP:0002418)	4.39598711
3	Pancreatic cysts (HP:0001737)	4.30933662
4	True hermaphroditism (HP:0010459)	4.15304263
5	Pancreatic fibrosis (HP:0100732)	4.12952261
6	Nephronophthisis (HP:0000090)	3.70916643
7	Congenital stationary night blindness (HP:0007642)	3.31983006
8	Increased hepatocellular lipid droplets (HP:0006565)	3.18252493
9	Acute necrotizing encephalopathy (HP:0006965)	3.18084943
10	Medial flaring of the eyebrow (HP:0010747)	3.14457143
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.12894744
12	Abnormality of alanine metabolism (HP:0010916)	3.12894744
13	Hyperalaninemia (HP:0003348)	3.12894744
14	Congenital, generalized hypertrichosis (HP:0004540)	3.04288355
15	Abnormality of the renal medulla (HP:0100957)	2.97343025
16	Lipid accumulation in hepatocytes (HP:0006561)	2.95399760
17	Mitochondrial inheritance (HP:0001427)	2.91336622
18	Type II lissencephaly (HP:0007260)	2.84888814
19	Acute encephalopathy (HP:0006846)	2.84277963
20	Progressive macrocephaly (HP:0004481)	2.83150243
21	Hypothermia (HP:0002045)	2.79438829
22	Large for gestational age (HP:0001520)	2.78022255
23	Abnormality of the renal cortex (HP:0011035)	2.77357992
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.73282349
25	Renal Fanconi syndrome (HP:0001994)	2.71032435
26	Increased CSF lactate (HP:0002490)	2.68784757
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.67534073
28	3-Methylglutaconic aciduria (HP:0003535)	2.67145095
29	Gait imbalance (HP:0002141)	2.59942440
30	Cystic liver disease (HP:0006706)	2.58449839
31	Sclerocornea (HP:0000647)	2.52553399
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.51362572
33	Absent/shortened dynein arms (HP:0200106)	2.51362572
34	Pendular nystagmus (HP:0012043)	2.51302343
35	Congenital primary aphakia (HP:0007707)	2.50660793
36	Chronic hepatic failure (HP:0100626)	2.48961716
37	Renal cortical cysts (HP:0000803)	2.48017002
38	Exertional dyspnea (HP:0002875)	2.46086304
39	Male pseudohermaphroditism (HP:0000037)	2.37674350
40	Abolished electroretinogram (ERG) (HP:0000550)	2.37321367
41	Furrowed tongue (HP:0000221)	2.36689377
42	Decreased central vision (HP:0007663)	2.33088520
43	Methylmalonic acidemia (HP:0002912)	2.31645566
44	Nephrogenic diabetes insipidus (HP:0009806)	2.30882051
45	Methylmalonic aciduria (HP:0012120)	2.28066000
46	Tubular atrophy (HP:0000092)	2.26456526
47	Attenuation of retinal blood vessels (HP:0007843)	2.26193647
48	Abnormality of the labia minora (HP:0012880)	2.22018863
49	Abnormal drinking behavior (HP:0030082)	2.21557707
50	Polydipsia (HP:0001959)	2.21557707
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21030113
52	Hypomagnesemia (HP:0002917)	2.20612342
53	Anencephaly (HP:0002323)	2.19168615
54	Bile duct proliferation (HP:0001408)	2.16440284
55	Abnormal biliary tract physiology (HP:0012439)	2.16440284
56	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15612613
57	Abnormal respiratory epithelium morphology (HP:0012253)	2.15612613
58	Optic disc pallor (HP:0000543)	2.14910904
59	Hyperventilation (HP:0002883)	2.14248766
60	Abnormality of renal resorption (HP:0011038)	2.11423594
61	Keratoconus (HP:0000563)	2.09405486
62	Increased corneal curvature (HP:0100692)	2.09405486
63	Colon cancer (HP:0003003)	2.08066140
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.05611767
65	Abnormality of the pons (HP:0007361)	2.04763097
66	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.04661969
67	Abnormal ciliary motility (HP:0012262)	2.04604171
68	Increased serum lactate (HP:0002151)	2.04231544
69	Genital tract atresia (HP:0001827)	2.03463584
70	Congenital hepatic fibrosis (HP:0002612)	2.01811457
71	Inability to walk (HP:0002540)	2.00362199
72	Hemiparesis (HP:0001269)	2.00224954
73	Vaginal atresia (HP:0000148)	1.96943445
74	Hepatocellular necrosis (HP:0001404)	1.96900144
75	Abnormality of urine glucose concentration (HP:0011016)	1.96792773
76	Glycosuria (HP:0003076)	1.96792773
77	Hepatic necrosis (HP:0002605)	1.95104663
78	Progressive inability to walk (HP:0002505)	1.94812738
79	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.93767972
80	Limb dystonia (HP:0002451)	1.92928326
81	Postaxial foot polydactyly (HP:0001830)	1.92520685
82	Tachypnea (HP:0002789)	1.91942606
83	Polyuria (HP:0000103)	1.91286002
84	Lissencephaly (HP:0001339)	1.91001710
85	Increased intramyocellular lipid droplets (HP:0012240)	1.89521150
86	Concave nail (HP:0001598)	1.89125171
87	Short tibia (HP:0005736)	1.87753881
88	Postaxial hand polydactyly (HP:0001162)	1.83322148
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.80597200
90	Hypoplasia of the pons (HP:0012110)	1.80428153
91	Constricted visual fields (HP:0001133)	1.78558872
92	Cerebellar dysplasia (HP:0007033)	1.78045672
93	Bony spicule pigmentary retinopathy (HP:0007737)	1.76424897
94	Lethargy (HP:0001254)	1.73930998
95	Progressive cerebellar ataxia (HP:0002073)	1.73563938
96	Lactic acidosis (HP:0003128)	1.72860207
97	Cerebral edema (HP:0002181)	1.72302458
98	Ketoacidosis (HP:0001993)	1.71501208
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.69833019
100	Thyroid-stimulating hormone excess (HP:0002925)	1.69187175

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.66178622
2	ADRBK2	3.42807274
3	ZAK	3.25614289
4	BMPR1B	3.05788808
5	PNCK	3.03071624
6	TAOK3	2.67883921
7	NUAK1	2.33267016
8	WNK3	2.32031169
9	GRK1	2.31060228
10	MAP4K2	2.28079507
11	TLK1	2.25793155
12	ACVR1B	2.24056457
13	MST4	2.12955981
14	TNIK	2.11233621
15	INSRR	1.98956752
16	TRIM28	1.96752578
17	PINK1	1.84754036
18	VRK1	1.83436183
19	WNK4	1.81253543
20	CASK	1.78208734
21	MAPK15	1.78177868
22	VRK2	1.74134426
23	MAPK13	1.63558949
24	MAP3K4	1.58418983
25	TXK	1.50300411
26	TSSK6	1.47443392
27	TAF1	1.37191056
28	DYRK2	1.31355678
29	DAPK2	1.30358204
30	NTRK3	1.28800105
31	WEE1	1.25685428
32	PAK3	1.11984686
33	PLK3	1.07032089
34	TGFBR1	1.04383180
35	PRKCG	1.01656707
36	STK16	1.00481339
37	ADRBK1	0.99216313
38	MKNK2	0.97344566
39	NME1	0.94885360
40	MAP3K12	0.94684594
41	OXSR1	0.94123049
42	BCR	0.91779887
43	MARK1	0.88555318
44	NTRK2	0.87559778
45	PASK	0.85959124
46	EIF2AK3	0.82997313
47	CSNK1G3	0.80211089
48	CSNK1G2	0.78808249
49	CSNK1G1	0.76096049
50	PRKCE	0.75920050
51	PLK2	0.74009972
52	GRK7	0.73302431
53	SIK2	0.73041097
54	MAP2K7	0.72334636
55	IKBKB	0.72311717
56	PHKG2	0.71688093
57	PHKG1	0.71688093
58	BCKDK	0.67471268
59	CDK19	0.66343672
60	PTK2B	0.66030842
61	MUSK	0.63901810
62	TIE1	0.63512985
63	CAMKK2	0.63277064
64	PLK4	0.61978825
65	STK39	0.57592256
66	FGFR2	0.56882101
67	CAMK2A	0.54272570
68	PRKCQ	0.53465203
69	MAPKAPK5	0.50440963
70	NEK1	0.50071323
71	TEC	0.49592090
72	NEK2	0.49361453
73	RPS6KA5	0.49207730
74	IRAK1	0.48662967
75	STK3	0.48487674
76	STK38L	0.47630024
77	DYRK3	0.46348857
78	CSNK1A1L	0.45280369
79	EPHB2	0.45232220
80	MKNK1	0.44889107
81	TNK2	0.43787612
82	CSNK1A1	0.40770428
83	PRKACA	0.39058730
84	PDK2	0.38943197
85	EIF2AK1	0.38728497
86	PLK1	0.38575479
87	CDK3	0.37146833
88	PKN1	0.36992754
89	CHUK	0.36496406
90	MAP2K6	0.36124565
91	CAMK2D	0.33048172
92	EIF2AK2	0.31522952
93	PRKCZ	0.30047581
94	PRKCA	0.29076308
95	MINK1	0.28406614
96	EPHA4	0.28353130
97	PRKG1	0.27539160
98	CHEK2	0.26992525
99	CAMK1	0.26726620
100	GRK5	0.26292987

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.63308733
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.79685069
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.78967376
4	Parkinsons disease_Homo sapiens_hsa05012	2.78745436
5	Protein export_Homo sapiens_hsa03060	2.43244819
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.35968834
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.34343546
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.27686586
9	Phototransduction_Homo sapiens_hsa04744	2.25120196
10	Butanoate metabolism_Homo sapiens_hsa00650	2.23436513
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.14245324
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.10238856
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07802811
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00328877
15	RNA polymerase_Homo sapiens_hsa03020	1.95973472
16	Homologous recombination_Homo sapiens_hsa03440	1.92040290
17	Basal transcription factors_Homo sapiens_hsa03022	1.87971369
18	Nicotine addiction_Homo sapiens_hsa05033	1.83478351
19	Alzheimers disease_Homo sapiens_hsa05010	1.81974025
20	Huntingtons disease_Homo sapiens_hsa05016	1.79737050
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77237175
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73471998
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.68220085
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.67327143
25	Ribosome_Homo sapiens_hsa03010	1.67032721
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60079631
27	Proteasome_Homo sapiens_hsa03050	1.49153431
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.46388349
29	One carbon pool by folate_Homo sapiens_hsa00670	1.45581396
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.44653680
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.38980047
32	Caffeine metabolism_Homo sapiens_hsa00232	1.32347850
33	Taste transduction_Homo sapiens_hsa04742	1.31030422
34	Regulation of autophagy_Homo sapiens_hsa04140	1.30869757
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.30223223
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.27547405
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.20336376
38	Peroxisome_Homo sapiens_hsa04146	1.12429790
39	Olfactory transduction_Homo sapiens_hsa04740	1.12070180
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.07032504
41	RNA degradation_Homo sapiens_hsa03018	1.05166883
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03443556
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01974738
44	Propanoate metabolism_Homo sapiens_hsa00640	1.01329251
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00602833
46	Insulin secretion_Homo sapiens_hsa04911	0.98050531
47	Asthma_Homo sapiens_hsa05310	0.97869744
48	Folate biosynthesis_Homo sapiens_hsa00790	0.97495129
49	Morphine addiction_Homo sapiens_hsa05032	0.89592435
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88618763
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87483732
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85986364
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85717931
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.80730440
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79573442
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78613181
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78360882
58	Purine metabolism_Homo sapiens_hsa00230	0.78163072
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77959915
60	GABAergic synapse_Homo sapiens_hsa04727	0.74712464
61	Serotonergic synapse_Homo sapiens_hsa04726	0.72825651
62	Metabolic pathways_Homo sapiens_hsa01100	0.68854999
63	Sulfur relay system_Homo sapiens_hsa04122	0.68250200
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67526599
65	ABC transporters_Homo sapiens_hsa02010	0.66935459
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.65789992
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63025699
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.61626870
69	Retinol metabolism_Homo sapiens_hsa00830	0.60360539
70	Mineral absorption_Homo sapiens_hsa04978	0.58053804
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58028467
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57965153
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.56928487
74	Circadian entrainment_Homo sapiens_hsa04713	0.55310694
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55309407
76	Fatty acid elongation_Homo sapiens_hsa00062	0.55181374
77	Cocaine addiction_Homo sapiens_hsa05030	0.52146854
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52086370
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.51050843
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50988120
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50941156
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50227817
83	Sulfur metabolism_Homo sapiens_hsa00920	0.49270284
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46122346
85	Glutathione metabolism_Homo sapiens_hsa00480	0.41629073
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41518907
87	Allograft rejection_Homo sapiens_hsa05330	0.40088402
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.38802162
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.37298595
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35432754
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34987747
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34667654
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.34618026
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.33116199
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.33067745
96	Amphetamine addiction_Homo sapiens_hsa05031	0.31516757
97	RNA transport_Homo sapiens_hsa03013	0.31392343
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.29225074
99	Salivary secretion_Homo sapiens_hsa04970	0.27236076
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27146607

DSTNP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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