DSTYK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound biosynthetic process (GO:0046189)4.56183026
2behavioral response to nicotine (GO:0035095)4.19743545
3melanocyte differentiation (GO:0030318)4.14946183
4L-amino acid import (GO:0043092)4.03998954
5pigment cell differentiation (GO:0050931)4.03302855
6melanosome organization (GO:0032438)4.01255225
7regulation of neurotransmitter uptake (GO:0051580)3.89963613
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.84437729
9pigment granule organization (GO:0048753)3.73704035
10locomotory exploration behavior (GO:0035641)3.71366080
11developmental pigmentation (GO:0048066)3.64771927
12synaptic vesicle maturation (GO:0016188)3.64102886
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60630838
14postsynaptic membrane organization (GO:0001941)3.58258400
15central nervous system myelination (GO:0022010)3.55037368
16axon ensheathment in central nervous system (GO:0032291)3.55037368
17dopamine transport (GO:0015872)3.50841603
18regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.44008344
19regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.44008344
20negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41612307
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40918224
22tyrosine metabolic process (GO:0006570)3.36516943
23behavioral response to ethanol (GO:0048149)3.29824263
24dopamine biosynthetic process (GO:0042416)3.24796440
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.20171361
26glutamate secretion (GO:0014047)3.19744724
27ketone body metabolic process (GO:1902224)3.12984021
28neuronal action potential propagation (GO:0019227)3.11083070
29amino acid import (GO:0043090)3.10160273
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09374352
31vocalization behavior (GO:0071625)3.09211371
32regulation of synaptic vesicle exocytosis (GO:2000300)3.08406935
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06707773
34synaptic vesicle exocytosis (GO:0016079)3.04790115
35neuroepithelial cell differentiation (GO:0060563)3.03938296
36protein localization to synapse (GO:0035418)3.02520164
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.95784018
38gamma-aminobutyric acid signaling pathway (GO:0007214)2.94993525
39atrial cardiac muscle cell action potential (GO:0086014)2.94925050
40glutamate receptor signaling pathway (GO:0007215)2.92588821
41inositol phosphate catabolic process (GO:0071545)2.91811480
42cellular potassium ion homeostasis (GO:0030007)2.87637426
43synaptic transmission, glutamatergic (GO:0035249)2.87457709
44cornea development in camera-type eye (GO:0061303)2.86566030
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85428606
46neuron cell-cell adhesion (GO:0007158)2.84021904
47regulation of glutamate receptor signaling pathway (GO:1900449)2.82220850
48positive regulation of neurotransmitter transport (GO:0051590)2.80498594
49neuron-neuron synaptic transmission (GO:0007270)2.80440818
50mating behavior (GO:0007617)2.79872795
51glycine transport (GO:0015816)2.77656223
52response to pheromone (GO:0019236)2.76053535
53adult walking behavior (GO:0007628)2.75763977
54melanin biosynthetic process (GO:0042438)2.75586229
55startle response (GO:0001964)2.74708484
56long-chain fatty acid biosynthetic process (GO:0042759)2.72349176
57layer formation in cerebral cortex (GO:0021819)2.71888040
58behavioral response to cocaine (GO:0048148)2.71332970
59nerve growth factor signaling pathway (GO:0038180)2.70393614
60transmission of nerve impulse (GO:0019226)2.69823298
61regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69382243
62platelet dense granule organization (GO:0060155)2.68399490
63regulation of synapse structural plasticity (GO:0051823)2.68221432
64long-term memory (GO:0007616)2.67945627
65peptidyl-tyrosine autophosphorylation (GO:0038083)2.66992935
66regulation of neuronal synaptic plasticity (GO:0048168)2.66832670
67regulation of synaptic vesicle transport (GO:1902803)2.66801128
68import into cell (GO:0098657)2.66648877
69myelination (GO:0042552)2.65575615
70membrane depolarization during action potential (GO:0086010)2.65259093
71endosome to melanosome transport (GO:0035646)2.64961037
72endosome to pigment granule transport (GO:0043485)2.64961037
73regulation of synaptic transmission, dopaminergic (GO:0032225)2.64181128
74melanosome localization (GO:0032400)2.63900039
75mechanosensory behavior (GO:0007638)2.62758821
76regulation of dopamine secretion (GO:0014059)2.62561332
77dendrite morphogenesis (GO:0048813)2.62354434
78ensheathment of neurons (GO:0007272)2.61807404
79axon ensheathment (GO:0008366)2.61807404
80gamma-aminobutyric acid transport (GO:0015812)2.60203525
81regulation of voltage-gated calcium channel activity (GO:1901385)2.60062994
82regulation of neurotransmitter transport (GO:0051588)2.59884151
83pigmentation (GO:0043473)2.58768104
84sodium ion export (GO:0071436)2.58579372
85presynaptic membrane assembly (GO:0097105)2.58345619
86protein K11-linked deubiquitination (GO:0035871)2.58294105
87alanine transport (GO:0032328)2.58088040
88long-term synaptic potentiation (GO:0060291)2.57229491
89neuron recognition (GO:0008038)2.57179293
90positive regulation of neurotransmitter secretion (GO:0001956)2.56209453
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56102323
92regulation of postsynaptic membrane potential (GO:0060078)2.55957983
93neuronal ion channel clustering (GO:0045161)2.55739750
94synaptic vesicle docking involved in exocytosis (GO:0016081)2.55488881
95response to amphetamine (GO:0001975)2.55328633
96exploration behavior (GO:0035640)2.54923303
97regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.54090249
98melanosome transport (GO:0032402)2.54044561
99dendritic spine morphogenesis (GO:0060997)2.53352281
100presynaptic membrane organization (GO:0097090)2.51601406
101regulation of long-term neuronal synaptic plasticity (GO:0048169)2.51494211
102catecholamine transport (GO:0051937)2.51443403
103piRNA metabolic process (GO:0034587)2.50871381
104auditory behavior (GO:0031223)2.50730985
105regulation of nuclear cell cycle DNA replication (GO:0033262)2.48799180
106synaptic transmission, cholinergic (GO:0007271)2.48733756
107neuron remodeling (GO:0016322)2.48470957
108pigment granule localization (GO:0051875)2.48411180
109establishment of melanosome localization (GO:0032401)2.48266085
110negative regulation of neurotransmitter secretion (GO:0046929)2.48179371
111neurotransmitter secretion (GO:0007269)2.47373742
112negative regulation of neurotransmitter transport (GO:0051589)2.47276674
113response to auditory stimulus (GO:0010996)2.46433378
114suckling behavior (GO:0001967)2.45636687
115cyclic nucleotide catabolic process (GO:0009214)2.45051812
116regulation of ARF protein signal transduction (GO:0032012)2.44985798
117synaptic vesicle endocytosis (GO:0048488)2.44731216
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44552577
119inositol phosphate dephosphorylation (GO:0046855)2.43485929
120phosphorylated carbohydrate dephosphorylation (GO:0046838)2.43485929
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42706262
122regulation of dendritic spine morphogenesis (GO:0061001)2.41173142
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40016609
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.39981193
125neuromuscular process controlling balance (GO:0050885)2.39113248
126auditory receptor cell stereocilium organization (GO:0060088)2.38332682
127secondary metabolite biosynthetic process (GO:0044550)2.37733756
128potassium ion import (GO:0010107)2.37094335
129pigment granule transport (GO:0051904)2.36891561
130melanin metabolic process (GO:0006582)2.36679716
131axonal fasciculation (GO:0007413)2.36257422
132potassium ion homeostasis (GO:0055075)2.35959702
133cerebellar Purkinje cell differentiation (GO:0021702)2.35695880
134eye photoreceptor cell differentiation (GO:0001754)2.34298755
135photoreceptor cell differentiation (GO:0046530)2.34298755
136detection of mechanical stimulus involved in sensory perception (GO:0050974)2.33979955
137regulation of integrin-mediated signaling pathway (GO:2001044)2.33777671
138preassembly of GPI anchor in ER membrane (GO:0016254)2.33737445
139cerebellar granule cell differentiation (GO:0021707)2.33736547
140neurotransmitter-gated ion channel clustering (GO:0072578)2.33717551
141establishment of pigment granule localization (GO:0051905)2.32110106
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.31073799
143membrane hyperpolarization (GO:0060081)2.30864346
144anterograde axon cargo transport (GO:0008089)2.30710974
145neurotransmitter transport (GO:0006836)2.30394913
146regulation of synaptic plasticity (GO:0048167)2.30142717
147negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.30106063
148protein localization to cilium (GO:0061512)2.30034732
149calcium ion-dependent exocytosis (GO:0017156)2.29886549
150regulation of collateral sprouting (GO:0048670)2.28903099
151pigment biosynthetic process (GO:0046148)2.27914936
152neural tube formation (GO:0001841)2.27887794
153neuronal action potential (GO:0019228)2.27838380
154neurotransmitter uptake (GO:0001504)2.27467582
155cilium morphogenesis (GO:0060271)2.27373354
156neuromuscular synaptic transmission (GO:0007274)2.27311283
157rhodopsin mediated signaling pathway (GO:0016056)2.27169876
158synapse assembly (GO:0007416)2.26475595
159positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.25840080
160positive regulation of membrane potential (GO:0045838)2.24908444
161membrane depolarization (GO:0051899)2.23943780
162proline transport (GO:0015824)2.23922696
163myelin maintenance (GO:0043217)2.23888512
164regulation of neurotransmitter secretion (GO:0046928)2.21988950
165regulation of dendritic spine development (GO:0060998)2.20898959
166innervation (GO:0060384)2.17822004
167regulation of clathrin-mediated endocytosis (GO:2000369)2.17789368
168positive regulation of synaptic transmission, GABAergic (GO:0032230)2.17645326
169cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.17619201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.84519292
2EZH2_22144423_ChIP-Seq_EOC_Human2.73658094
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45243282
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43137021
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35119049
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.29897257
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25335083
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25335083
9VDR_22108803_ChIP-Seq_LS180_Human2.22949388
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12856688
11AR_21572438_ChIP-Seq_LNCaP_Human2.11398049
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10731230
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10280348
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01574746
15FUS_26573619_Chip-Seq_HEK293_Human2.01034151
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00404183
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98808658
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.94549495
19DROSHA_22980978_ChIP-Seq_HELA_Human1.87600946
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.87064529
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.84154792
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.83956857
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.81889396
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79753177
25EWS_26573619_Chip-Seq_HEK293_Human1.78905405
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78016162
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76183228
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70361456
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66643241
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.66125956
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63855137
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59022382
33TAF15_26573619_Chip-Seq_HEK293_Human1.57984711
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53055184
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52305232
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52030831
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51804461
38SMAD4_21799915_ChIP-Seq_A2780_Human1.51140143
39* RARB_27405468_Chip-Seq_BRAIN_Mouse1.50238421
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49384660
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48968570
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.48813825
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47214847
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44076874
45* EZH2_27294783_Chip-Seq_NPCs_Mouse1.42500809
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42376835
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42366481
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41230743
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40039043
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40013864
51TP53_16413492_ChIP-PET_HCT116_Human1.38339660
52* NANOG_18555785_Chip-Seq_ESCs_Mouse1.37846672
53FLI1_21867929_ChIP-Seq_TH2_Mouse1.37798705
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36563944
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35491691
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34737074
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34566058
58REST_21632747_ChIP-Seq_MESCs_Mouse1.33180105
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33153596
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33153596
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32495952
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32382137
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31780497
64CBP_20019798_ChIP-Seq_JUKART_Human1.29334756
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29334756
66JUN_21703547_ChIP-Seq_K562_Human1.28347576
67IGF1R_20145208_ChIP-Seq_DFB_Human1.27754902
68ZNF274_21170338_ChIP-Seq_K562_Hela1.27480765
69* NFE2_27457419_Chip-Seq_LIVER_Mouse1.26615011
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.26537158
71* P53_22387025_ChIP-Seq_ESCs_Mouse1.26424041
72P300_19829295_ChIP-Seq_ESCs_Human1.26301267
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26079463
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.25824189
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25771620
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.25696547
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.25140725
78* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23814141
79STAT3_23295773_ChIP-Seq_U87_Human1.23794161
80* CRX_20693478_ChIP-Seq_RETINA_Mouse1.23729531
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23519939
82AHR_22903824_ChIP-Seq_MCF-7_Human1.22495955
83GATA1_22025678_ChIP-Seq_K562_Human1.22396240
84TCF4_22108803_ChIP-Seq_LS180_Human1.21595086
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21423917
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21423917
87* E2F1_18555785_Chip-Seq_ESCs_Mouse1.18182028
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17838737
89* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17358507
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.16890349
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16670280
92TP53_18474530_ChIP-ChIP_U2OS_Human1.16448957
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16152501
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16124733
95* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.15930872
96BCAT_22108803_ChIP-Seq_LS180_Human1.15919592
97AR_25329375_ChIP-Seq_VCAP_Human1.15756814
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15419273
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.15049088
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.12732479
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.11838096
102TCF4_23295773_ChIP-Seq_U87_Human1.10758642
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10374194
104SMAD3_21741376_ChIP-Seq_ESCs_Human1.09883358
105* CMYC_18555785_Chip-Seq_ESCs_Mouse1.09470504
106* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09324209
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08317378
108RXR_22108803_ChIP-Seq_LS180_Human1.08066702
109* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07673096
110KDM2B_26808549_Chip-Seq_REH_Human1.07138950
111* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06448413
112* ER_23166858_ChIP-Seq_MCF-7_Human1.06243927
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05539666
114SOX9_26525672_Chip-Seq_HEART_Mouse1.05033278
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.05009960
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03321534
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02767729
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00936084
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.00714290
120AR_19668381_ChIP-Seq_PC3_Human0.99721183
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98412504
122RUNX2_22187159_ChIP-Seq_PCA_Human0.98055991
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97313741
124BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96890407
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96537445
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96370725
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95997915
128* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95168301
129* RING1B_27294783_Chip-Seq_ESCs_Mouse0.95156756
130RING1B_27294783_Chip-Seq_NPCs_Mouse0.93213402
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92527511
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92425938
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.91545784
134* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91184233
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.90629138
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.89795658
137RNF2_27304074_Chip-Seq_NSC_Mouse0.89740912
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89128126
139* KDM2B_26808549_Chip-Seq_K562_Human0.88071442
140* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87663165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.69283887
2MP0005171_absent_coat_pigmentation3.64504353
3MP0005174_abnormal_tail_pigmentation3.35507857
4MP0003880_abnormal_central_pattern3.26222621
5MP0005075_abnormal_melanosome_morpholog3.25562926
6MP0003635_abnormal_synaptic_transmissio2.97327273
7MP0002095_abnormal_skin_pigmentation2.91122373
8MP0009046_muscle_twitch2.78879186
9MP0004270_analgesia2.67520578
10MP0009745_abnormal_behavioral_response2.65493939
11MP0002064_seizures2.64104910
12MP0002102_abnormal_ear_morphology2.49468957
13MP0001486_abnormal_startle_reflex2.48287879
14MP0003950_abnormal_plasma_membrane2.35952262
15MP0000920_abnormal_myelination2.35897228
16MP0002272_abnormal_nervous_system2.33668930
17MP0002063_abnormal_learning/memory/cond2.18775536
18MP0000371_diluted_coat_color2.15108270
19MP0005409_darkened_coat_color2.13119625
20MP0004885_abnormal_endolymph2.07410330
21MP0003690_abnormal_glial_cell2.07100620
22MP0000372_irregular_coat_pigmentation1.94453868
23MP0001968_abnormal_touch/_nociception1.91717291
24MP0002938_white_spotting1.89456737
25MP0002572_abnormal_emotion/affect_behav1.81473006
26MP0002837_dystrophic_cardiac_calcinosis1.78509935
27MP0002734_abnormal_mechanical_nocicepti1.76525043
28MP0008569_lethality_at_weaning1.71076646
29MP0002822_catalepsy1.69590318
30MP0003787_abnormal_imprinting1.68297023
31MP0001188_hyperpigmentation1.66868863
32MP0000569_abnormal_digit_pigmentation1.65551797
33MP0005646_abnormal_pituitary_gland1.64985470
34MP0003329_amyloid_beta_deposits1.64242160
35MP0005257_abnormal_intraocular_pressure1.63630003
36MP0004742_abnormal_vestibular_system1.63093978
37MP0002067_abnormal_sensory_capabilities1.62739021
38MP0002736_abnormal_nociception_after1.61978720
39MP0003646_muscle_fatigue1.59009890
40MP0002075_abnormal_coat/hair_pigmentati1.55403781
41MP0000778_abnormal_nervous_system1.54440375
42MP0005551_abnormal_eye_electrophysiolog1.53612302
43MP0002090_abnormal_vision1.51804144
44MP0003136_yellow_coat_color1.51485659
45MP0001501_abnormal_sleep_pattern1.48100301
46MP0005377_hearing/vestibular/ear_phenot1.45933676
47MP0003878_abnormal_ear_physiology1.45933676
48MP0005623_abnormal_meninges_morphology1.45116954
49MP0009780_abnormal_chondrocyte_physiolo1.42169587
50MP0003634_abnormal_glial_cell1.41291797
51MP0005423_abnormal_somatic_nervous1.40651609
52MP0001299_abnormal_eye_distance/1.36601416
53MP0004147_increased_porphyrin_level1.36579905
54MP0001440_abnormal_grooming_behavior1.35809479
55MP0004924_abnormal_behavior1.32459849
56MP0005386_behavior/neurological_phenoty1.32459849
57MP0003633_abnormal_nervous_system1.31619498
58MP0005248_abnormal_Harderian_gland1.30349806
59MP0001502_abnormal_circadian_rhythm1.28761179
60MP0005253_abnormal_eye_physiology1.28371912
61MP0001970_abnormal_pain_threshold1.27072073
62MP0002882_abnormal_neuron_morphology1.26744373
63MP0001177_atelectasis1.26241431
64MP0003631_nervous_system_phenotype1.24523501
65MP0005645_abnormal_hypothalamus_physiol1.24209661
66MP0003632_abnormal_nervous_system1.24136092
67MP0001186_pigmentation_phenotype1.24009182
68MP0000955_abnormal_spinal_cord1.23445145
69MP0009278_abnormal_bone_marrow1.22252415
70MP0002557_abnormal_social/conspecific_i1.19440972
71MP0002229_neurodegeneration1.18516112
72MP0002184_abnormal_innervation1.15684517
73MP0005408_hypopigmentation1.15504005
74MP0004145_abnormal_muscle_electrophysio1.14594942
75MP0000751_myopathy1.12467385
76MP0006276_abnormal_autonomic_nervous1.09017608
77MP0000015_abnormal_ear_pigmentation1.07121213
78MP0002735_abnormal_chemical_nociception1.06748427
79MP0004142_abnormal_muscle_tone1.05165631
80MP0004811_abnormal_neuron_physiology1.05141774
81MP0002066_abnormal_motor_capabilities/c1.04765999
82MP0002733_abnormal_thermal_nociception1.04339377
83MP0004043_abnormal_pH_regulation1.02278257
84MP0000427_abnormal_hair_cycle1.01083682
85MP0001905_abnormal_dopamine_level0.99652165
86MP0006292_abnormal_olfactory_placode0.98946838
87MP0004858_abnormal_nervous_system0.97681759
88MP0003091_abnormal_cell_migration0.96310941
89MP0004381_abnormal_hair_follicle0.96281608
90MP0008877_abnormal_DNA_methylation0.94916325
91MP0001984_abnormal_olfaction0.92670306
92MP0006072_abnormal_retinal_apoptosis0.90841270
93MP0000647_abnormal_sebaceous_gland0.85291414
94MP0000604_amyloidosis0.85255930
95MP0010386_abnormal_urinary_bladder0.85218119
96MP0001963_abnormal_hearing_physiology0.83690849
97MP0005187_abnormal_penis_morphology0.83439416
98MP0000631_abnormal_neuroendocrine_gland0.83191423
99MP0001346_abnormal_lacrimal_gland0.81472311
100MP0002752_abnormal_somatic_nervous0.81306394
101MP0002877_abnormal_melanocyte_morpholog0.80187880
102MP0002909_abnormal_adrenal_gland0.80026104
103MP0004085_abnormal_heartbeat0.78788973
104MP0003045_fibrosis0.78717257
105MP0000747_muscle_weakness0.77754970
106MP0008438_abnormal_cutaneous_collagen0.77495900
107MP0002152_abnormal_brain_morphology0.77322830
108MP0004272_abnormal_basement_membrane0.77002520
109MP0002177_abnormal_outer_ear0.75317504
110MP0000534_abnormal_ureter_morphology0.72813341
111MP0001324_abnormal_eye_pigmentation0.72716741
112MP0008874_decreased_physiological_sensi0.70419532
113MP0001485_abnormal_pinna_reflex0.69932575
114MP0001529_abnormal_vocalization0.69469818
115MP0004134_abnormal_chest_morphology0.68613791
116MP0003075_altered_response_to0.68168129
117MP0001293_anophthalmia0.67914475
118MP0004510_myositis0.67026960
119MP0002108_abnormal_muscle_morphology0.66531116
120MP0003172_abnormal_lysosome_physiology0.66214160
121MP0004484_altered_response_of0.65797929
122MP0002638_abnormal_pupillary_reflex0.64925517
123MP0005195_abnormal_posterior_eye0.64844805
124MP0002133_abnormal_respiratory_system0.64807674
125MP0005388_respiratory_system_phenotype0.64807674
126MP0010678_abnormal_skin_adnexa0.63958738
127MP0005197_abnormal_uvea_morphology0.63816379
128MP0004036_abnormal_muscle_relaxation0.63046375
129MP0008961_abnormal_basal_metabolism0.61353230
130MP0002928_abnormal_bile_duct0.60683051
131MP0001919_abnormal_reproductive_system0.59347459
132MP0008872_abnormal_physiological_respon0.55528733
133MP0005391_vision/eye_phenotype0.53780905
134MP0000026_abnormal_inner_ear0.51670480

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)5.14856978
2Hypoplasia of the fovea (HP:0007750)5.14856978
3Aplasia/Hypoplasia of the macula (HP:0008059)4.92927089
4Focal motor seizures (HP:0011153)4.63103059
5Aplasia/Hypoplasia affecting the retina (HP:0008061)4.52087459
6Myokymia (HP:0002411)4.04373838
7Epileptic encephalopathy (HP:0200134)4.00503542
8Focal seizures (HP:0007359)3.86462516
9Febrile seizures (HP:0002373)3.84103803
10Generalized hypopigmentation (HP:0007513)3.82925519
11Albinism (HP:0001022)3.80288095
12Action tremor (HP:0002345)3.64001689
13Blue irides (HP:0000635)3.62114166
14Pancreatic cysts (HP:0001737)3.57118666
15Atonic seizures (HP:0010819)3.55528103
16Neurofibrillary tangles (HP:0002185)3.54983812
17Decreased central vision (HP:0007663)3.39790369
18Congenital stationary night blindness (HP:0007642)3.36476664
19Pancreatic fibrosis (HP:0100732)3.29888303
20Supranuclear gaze palsy (HP:0000605)3.20009185
21True hermaphroditism (HP:0010459)3.16639439
22Hypopigmentation of the fundus (HP:0007894)3.15570011
23Abnormality of midbrain morphology (HP:0002418)3.07877990
24Molar tooth sign on MRI (HP:0002419)3.07877990
25Type II lissencephaly (HP:0007260)3.05932167
26Aplasia involving bones of the upper limbs (HP:0009823)3.03698544
27Aplasia of the phalanges of the hand (HP:0009802)3.03698544
28Aplasia involving bones of the extremities (HP:0009825)3.03698544
29Hyperventilation (HP:0002883)2.94646906
30Congenital sensorineural hearing impairment (HP:0008527)2.86789433
31Onion bulb formation (HP:0003383)2.83211014
32Progressive cerebellar ataxia (HP:0002073)2.79524134
33Cerebral inclusion bodies (HP:0100314)2.79217822
34Medial flaring of the eyebrow (HP:0010747)2.78894666
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73889104
36Dysmetria (HP:0001310)2.72938425
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.69788029
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.69788029
39Hypoplasia of the iris (HP:0007676)2.68933755
40Ankle clonus (HP:0011448)2.67548581
41Generalized hypopigmentation of hair (HP:0011358)2.66697412
42Intention tremor (HP:0002080)2.66131134
43Limb dystonia (HP:0002451)2.65058937
44Gait imbalance (HP:0002141)2.60255707
45Postural instability (HP:0002172)2.58842157
46Heterochromia iridis (HP:0001100)2.57611596
47Generalized tonic-clonic seizures (HP:0002069)2.56661128
48Keratoconus (HP:0000563)2.56240717
49Increased corneal curvature (HP:0100692)2.56240717
50Absence seizures (HP:0002121)2.55150791
51Nephronophthisis (HP:0000090)2.52218826
52Dialeptic seizures (HP:0011146)2.48526328
53Abnormal drinking behavior (HP:0030082)2.41353807
54Polydipsia (HP:0001959)2.41353807
55Scanning speech (HP:0002168)2.41291958
56Gaze-evoked nystagmus (HP:0000640)2.39948836
57Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.39212526
58Nephrogenic diabetes insipidus (HP:0009806)2.36262284
59Termporal pattern (HP:0011008)2.35548600
60Insidious onset (HP:0003587)2.35548600
61Abnormality of the corticospinal tract (HP:0002492)2.33940517
62Spastic gait (HP:0002064)2.32206555
63Visual hallucinations (HP:0002367)2.28509191
64Congenital primary aphakia (HP:0007707)2.28163362
65Lower limb amyotrophy (HP:0007210)2.24297819
66Cerebellar dysplasia (HP:0007033)2.23452401
67Cystic liver disease (HP:0006706)2.23428627
68Abnormality of the renal medulla (HP:0100957)2.21431228
69Dysdiadochokinesis (HP:0002075)2.19692599
70Prolonged QT interval (HP:0001657)2.18865469
71Peripheral hypomyelination (HP:0007182)2.18515357
72Increased variability in muscle fiber diameter (HP:0003557)2.18039434
73Urinary bladder sphincter dysfunction (HP:0002839)2.17912639
74Absent speech (HP:0001344)2.16206793
75Lower limb muscle weakness (HP:0007340)2.15706239
76White forelock (HP:0002211)2.14773088
77Nonprogressive disorder (HP:0003680)2.13911629
78Broad-based gait (HP:0002136)2.12642555
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10923810
80Arterial tortuosity (HP:0005116)2.08800110
81Ocular albinism (HP:0001107)2.08609901
82Sensory axonal neuropathy (HP:0003390)2.08250806
83Tubular atrophy (HP:0000092)2.07160733
84Abnormal auditory evoked potentials (HP:0006958)2.05711532
85Clumsiness (HP:0002312)2.03952928
86Hemiparesis (HP:0001269)2.03665620
87Depression (HP:0000716)2.03577712
88Truncal ataxia (HP:0002078)2.03224089
89Poor eye contact (HP:0000817)2.03096325
90Abnormality of the renal cortex (HP:0011035)2.01632389
91Widely spaced teeth (HP:0000687)1.99414557
92Chronic hepatic failure (HP:0100626)1.98524665
93Anxiety (HP:0000739)1.98009372
94Vascular tortuosity (HP:0004948)1.97492347
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.96480981
96Astigmatism (HP:0000483)1.95702414
97Bradycardia (HP:0001662)1.95585841
98Abnormality of the periventricular white matter (HP:0002518)1.94244831
99Submucous cleft hard palate (HP:0000176)1.93702772
100Hamartoma of the eye (HP:0010568)1.93626323
101Scapular winging (HP:0003691)1.92979358
102Central scotoma (HP:0000603)1.92600509
103Axonal loss (HP:0003447)1.89436384
104Increased cerebral lipofuscin (HP:0011813)1.87358377
105Iris hypopigmentation (HP:0007730)1.86987652
106Abnormality of the astrocytes (HP:0100707)1.86692621
107Astrocytoma (HP:0009592)1.86692621
108Torticollis (HP:0000473)1.85792108
109Patchy hypopigmentation of hair (HP:0011365)1.85600186
110Drooling (HP:0002307)1.85345348
111Excessive salivation (HP:0003781)1.85345348
112Hyporeflexia of lower limbs (HP:0002600)1.84350167
113Broad metatarsal (HP:0001783)1.83875459
114Diplopia (HP:0000651)1.83753474
115Abnormality of binocular vision (HP:0011514)1.83753474
116Abnormal social behavior (HP:0012433)1.82688600
117Impaired social interactions (HP:0000735)1.82688600
118Premature graying of hair (HP:0002216)1.81797318
119Generalized myoclonic seizures (HP:0002123)1.81688644
120Freckling (HP:0001480)1.80500583
121Global brain atrophy (HP:0002283)1.80171400
122Severe Myopia (HP:0011003)1.79420778
123Hypoventilation (HP:0002791)1.79372457
124Glioma (HP:0009733)1.78380721
125Insomnia (HP:0100785)1.78078326
126Retinal dysplasia (HP:0007973)1.77379416
127Abnormality of skeletal muscle fiber size (HP:0012084)1.76458919
128Protruding tongue (HP:0010808)1.75743455
129Congenital hepatic fibrosis (HP:0002612)1.75534017
130Megalencephaly (HP:0001355)1.74070976
131Postaxial hand polydactyly (HP:0001162)1.73698619
132Cutaneous melanoma (HP:0012056)1.73586154
133Genital tract atresia (HP:0001827)1.72979263
134Atrial fibrillation (HP:0005110)1.72812805
135Progressive inability to walk (HP:0002505)1.72176383
136Furrowed tongue (HP:0000221)1.71433300
137Large for gestational age (HP:0001520)1.71381064
138Bowel incontinence (HP:0002607)1.71327077
139Volvulus (HP:0002580)1.71153904
140Alacrima (HP:0000522)1.71105860
141Vaginal atresia (HP:0000148)1.71066181
142Abnormal rod and cone electroretinograms (HP:0008323)1.70683201
143Neuroendocrine neoplasm (HP:0100634)1.70582222
144Poor coordination (HP:0002370)1.68994659
145Distal lower limb amyotrophy (HP:0008944)1.67830257
146Gowers sign (HP:0003391)1.67719468
147Ependymoma (HP:0002888)1.67657423
148Increased neuronal autofluorescent lipopigment (HP:0002074)1.67232527
149Difficulty running (HP:0009046)1.66691999
150Neuronal loss in central nervous system (HP:0002529)1.66438182
151Fibular hypoplasia (HP:0003038)1.66309162
152Slow saccadic eye movements (HP:0000514)1.65689063
153Spinal rigidity (HP:0003306)1.65202726
154Polyuria (HP:0000103)1.64563382
155Genetic anticipation (HP:0003743)1.64410578
156Abnormality of macular pigmentation (HP:0008002)1.63817348
157Macroorchidism (HP:0000053)1.63798130
158Upper limb amyotrophy (HP:0009129)1.63500085
159Distal upper limb amyotrophy (HP:0007149)1.63500085
160Abnormal eating behavior (HP:0100738)1.62923370
161Abnormality of the fovea (HP:0000493)1.62170469
162Inability to walk (HP:0002540)1.62085151
163Aplasia/Hypoplasia of the fibula (HP:0006492)1.61681219
164Oligodactyly (hands) (HP:0001180)1.61459365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA42.97558124
2MAP3K42.83691675
3NTRK32.64163431
4MAP2K72.43863057
5PRPF4B2.29313372
6CASK2.26748768
7WEE12.12860591
8STK392.09200131
9PDK21.95690344
10OXSR11.95150519
11SGK2231.91339981
12SGK4941.91339981
13ADRBK21.90725582
14MAP4K21.85429553
15WNK31.84640906
16NTRK11.76560323
17TNIK1.76208737
18AKT31.69008847
19PKN11.68244568
20MARK31.68233610
21NUAK11.64970146
22MAP2K41.62445553
23MAP3K91.62373630
24DAPK21.58763067
25PAK61.54249911
26NTRK21.51501856
27CAMK1G1.47735436
28FES1.45707464
29WNK11.44509488
30RIPK41.41905785
31INSRR1.33029669
32BMPR21.32768357
33SGK21.23705588
34CAMKK11.22290604
35MUSK1.20588499
36RET1.18689347
37CDK51.17444504
38MINK11.15923953
39NEK61.14348252
40MAPKAPK51.13977395
41PRKD31.12188329
42CSNK1G11.11934871
43ADRBK11.09813615
44DDR21.07364794
45TYRO31.05016490
46CDK31.04946902
47MAP3K21.04131387
48MARK11.02743743
49CAMKK21.02641378
50MAP3K131.02307371
51KSR21.02182821
52PRKCE0.99633637
53SGK30.99337314
54PHKG10.99183490
55PHKG20.99183490
56EPHB10.98373418
57MST1R0.98251847
58MARK20.98085762
59PRKCG0.98021877
60DYRK1A0.97286813
61STK380.97218615
62TRPM70.94966027
63FGFR20.94534593
64PIK3CA0.93650494
65ACVR1B0.92671979
66ZAK0.92214582
67PRKCH0.91594882
68DMPK0.88981737
69CAMK2B0.86845504
70CAMK2A0.86688097
71PLK30.86358519
72CAMK1D0.85757844
73SGK10.84628863
74TXK0.84560886
75CSNK1G20.83531316
76CAMK2D0.83489030
77FER0.83274351
78PAK30.81583486
79CSNK1A1L0.80599536
80BMPR1B0.79867756
81STK30.79660666
82LATS10.79407654
83TAOK30.78753056
84PNCK0.76807022
85ROCK20.76586687
86MET0.76290527
87FRK0.75184537
88ERBB20.74219927
89PLK20.72551916
90GRK50.71478253
91CDK190.71163054
92BCKDK0.70841536
93GRK10.70388511
94FGR0.70323513
95DYRK20.68690253
96WNK40.68066657
97STK110.67710685
98GSK3A0.66987247
99TRIM280.66306684
100PDPK10.66131207
101CAMK10.65077765
102MAPK130.63117057
103PINK10.62897407
104CAMK2G0.61352067
105PDGFRB0.61237721
106FYN0.60904041
107ERBB30.59250291
108TNK20.59196638
109UHMK10.58525459
110RIPK10.58410669
111GRK70.55309815
112MAPKAPK30.52929001
113BCR0.52678566
114PRKD10.52640820
115CSNK1D0.51575048
116PTK2B0.51369751
117MAP3K70.49785726
118BMX0.49332449
119HIPK20.48979286
120PDK10.48936630
121STK38L0.46919444
122CSNK1G30.46035899
123SIK20.45438582
124ICK0.45133347
125MAPK70.45061642
126CSNK1A10.44279200
127MOS0.44108669
128PTK60.43961991
129CAMK40.43633498
130TIE10.43094591
131IRAK10.42602725
132FGFR10.41742560
133MKNK20.38587424
134EPHA30.36991392
135TGFBR10.36525342
136MAPK120.36158180
137PRKACA0.35921336
138ATM0.33046034
139EIF2AK20.31803547
140EIF2AK30.29957696
141PRKCA0.29003656
142MAP2K10.28862087

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.44515640
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28677431
3GABAergic synapse_Homo sapiens_hsa047272.14965782
4Olfactory transduction_Homo sapiens_hsa047402.12758796
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10461828
6Glutamatergic synapse_Homo sapiens_hsa047242.09488573
7Circadian entrainment_Homo sapiens_hsa047132.05124393
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00078464
9Morphine addiction_Homo sapiens_hsa050321.99610925
10Synaptic vesicle cycle_Homo sapiens_hsa047211.95797554
11Salivary secretion_Homo sapiens_hsa049701.78407715
12Long-term potentiation_Homo sapiens_hsa047201.59781125
13Cholinergic synapse_Homo sapiens_hsa047251.59518068
14Gastric acid secretion_Homo sapiens_hsa049711.55917310
15Renin secretion_Homo sapiens_hsa049241.54874792
16Long-term depression_Homo sapiens_hsa047301.54547816
17Protein export_Homo sapiens_hsa030601.53242334
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52923137
19Dopaminergic synapse_Homo sapiens_hsa047281.50110749
20Axon guidance_Homo sapiens_hsa043601.45838872
21Propanoate metabolism_Homo sapiens_hsa006401.45367550
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44910804
23Amphetamine addiction_Homo sapiens_hsa050311.43271533
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41005925
25Serotonergic synapse_Homo sapiens_hsa047261.40298086
26Insulin secretion_Homo sapiens_hsa049111.37710527
27Cocaine addiction_Homo sapiens_hsa050301.35756059
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.33174908
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32815265
30Oxytocin signaling pathway_Homo sapiens_hsa049211.32004434
31GnRH signaling pathway_Homo sapiens_hsa049121.31880678
32Basal transcription factors_Homo sapiens_hsa030221.29847055
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28479319
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27641992
35Calcium signaling pathway_Homo sapiens_hsa040201.27488718
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25834843
37Linoleic acid metabolism_Homo sapiens_hsa005911.25553843
38Taste transduction_Homo sapiens_hsa047421.24074341
39Type II diabetes mellitus_Homo sapiens_hsa049301.22388834
40cAMP signaling pathway_Homo sapiens_hsa040241.21644950
41Phototransduction_Homo sapiens_hsa047441.21082364
42Gap junction_Homo sapiens_hsa045401.17102799
43Oxidative phosphorylation_Homo sapiens_hsa001901.15193575
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14908898
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13521325
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12962323
47ABC transporters_Homo sapiens_hsa020101.12132918
48Homologous recombination_Homo sapiens_hsa034401.10565198
49Butanoate metabolism_Homo sapiens_hsa006501.07730441
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.07272659
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.06496928
52Dilated cardiomyopathy_Homo sapiens_hsa054141.03493244
53ErbB signaling pathway_Homo sapiens_hsa040121.02833707
54Sphingolipid metabolism_Homo sapiens_hsa006001.02760275
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01373330
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00379264
57Melanogenesis_Homo sapiens_hsa049160.99921126
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.99454766
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99318002
60Fanconi anemia pathway_Homo sapiens_hsa034600.96505627
61Collecting duct acid secretion_Homo sapiens_hsa049660.93525080
62Estrogen signaling pathway_Homo sapiens_hsa049150.92848052
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91422206
64Parkinsons disease_Homo sapiens_hsa050120.90783841
65Dorso-ventral axis formation_Homo sapiens_hsa043200.90404621
66Glioma_Homo sapiens_hsa052140.87446791
67Choline metabolism in cancer_Homo sapiens_hsa052310.86855236
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85732816
69Hippo signaling pathway_Homo sapiens_hsa043900.85180455
70One carbon pool by folate_Homo sapiens_hsa006700.84210665
71Regulation of autophagy_Homo sapiens_hsa041400.82547468
72Pancreatic secretion_Homo sapiens_hsa049720.82447597
73Ras signaling pathway_Homo sapiens_hsa040140.82302020
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81956162
75Renal cell carcinoma_Homo sapiens_hsa052110.78899719
76Inositol phosphate metabolism_Homo sapiens_hsa005620.78292011
77Ovarian steroidogenesis_Homo sapiens_hsa049130.77863260
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76254023
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76066976
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75751673
81MAPK signaling pathway_Homo sapiens_hsa040100.74914767
82Cardiac muscle contraction_Homo sapiens_hsa042600.71910379
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71705552
84Hedgehog signaling pathway_Homo sapiens_hsa043400.71498667
85Rap1 signaling pathway_Homo sapiens_hsa040150.70898505
86Ether lipid metabolism_Homo sapiens_hsa005650.70521387
87ECM-receptor interaction_Homo sapiens_hsa045120.69581661
88Alzheimers disease_Homo sapiens_hsa050100.68500753
89beta-Alanine metabolism_Homo sapiens_hsa004100.67856603
90Rheumatoid arthritis_Homo sapiens_hsa053230.67119590
91Vibrio cholerae infection_Homo sapiens_hsa051100.67054769
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66402380
93RNA polymerase_Homo sapiens_hsa030200.65603869
94Nitrogen metabolism_Homo sapiens_hsa009100.65253297
95Tyrosine metabolism_Homo sapiens_hsa003500.64684179
96Thyroid hormone synthesis_Homo sapiens_hsa049180.63550698
97Focal adhesion_Homo sapiens_hsa045100.63216701
98Tryptophan metabolism_Homo sapiens_hsa003800.62893632
99RNA degradation_Homo sapiens_hsa030180.61188151
100Endocytosis_Homo sapiens_hsa041440.61010891
101Platelet activation_Homo sapiens_hsa046110.60999059
102Chemokine signaling pathway_Homo sapiens_hsa040620.60202409
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58598496
104Amoebiasis_Homo sapiens_hsa051460.58336317
105Tight junction_Homo sapiens_hsa045300.58264488
106Melanoma_Homo sapiens_hsa052180.57231307
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.56451771
108Lysosome_Homo sapiens_hsa041420.56167724
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.56059230
110Wnt signaling pathway_Homo sapiens_hsa043100.55914756
111Selenocompound metabolism_Homo sapiens_hsa004500.55126833
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52929804
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52788213
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52542927
115African trypanosomiasis_Homo sapiens_hsa051430.50992751
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50920660
117Oocyte meiosis_Homo sapiens_hsa041140.50508401
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49807899
119Basal cell carcinoma_Homo sapiens_hsa052170.48698360
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47683371
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46931403
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46823418
123Proteoglycans in cancer_Homo sapiens_hsa052050.46469452
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45878508
125Phagosome_Homo sapiens_hsa041450.45279068
126mTOR signaling pathway_Homo sapiens_hsa041500.44771292
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44220084
128Pancreatic cancer_Homo sapiens_hsa052120.43964957
129TGF-beta signaling pathway_Homo sapiens_hsa043500.43924986
130Peroxisome_Homo sapiens_hsa041460.41849442
131Endometrial cancer_Homo sapiens_hsa052130.40789432
132Circadian rhythm_Homo sapiens_hsa047100.40648596
133Salmonella infection_Homo sapiens_hsa051320.40034657
134Fatty acid elongation_Homo sapiens_hsa000620.39779315
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39452253
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.38429678
137Huntingtons disease_Homo sapiens_hsa050160.38372667
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37743362
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37205936
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37198414
141Purine metabolism_Homo sapiens_hsa002300.35551467
142Lysine degradation_Homo sapiens_hsa003100.34929307

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