DTD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.20207329
2ATP synthesis coupled proton transport (GO:0015986)5.88852097
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.88852097
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.42105067
5pyrimidine nucleobase catabolic process (GO:0006208)5.20094039
6sequestering of actin monomers (GO:0042989)4.98151040
7neuron cell-cell adhesion (GO:0007158)4.96224782
8chaperone-mediated protein transport (GO:0072321)4.78054439
9respiratory electron transport chain (GO:0022904)4.71146977
10electron transport chain (GO:0022900)4.63613460
11protein complex biogenesis (GO:0070271)4.35297440
12dopamine transport (GO:0015872)4.24038763
13vocalization behavior (GO:0071625)4.13143330
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.11752284
15NADH dehydrogenase complex assembly (GO:0010257)4.11752284
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11752284
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.09619371
18nucleobase catabolic process (GO:0046113)4.09226699
19presynaptic membrane assembly (GO:0097105)4.02469071
20mitochondrial respiratory chain complex assembly (GO:0033108)4.01340285
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.00906817
22synaptic vesicle exocytosis (GO:0016079)3.86763217
23inner mitochondrial membrane organization (GO:0007007)3.86554891
24positive regulation of mitochondrial fission (GO:0090141)3.84256433
25postsynaptic membrane organization (GO:0001941)3.75912736
26protein localization to synapse (GO:0035418)3.73505685
27presynaptic membrane organization (GO:0097090)3.64692784
28DNA damage response, detection of DNA damage (GO:0042769)3.64552801
29proteasome assembly (GO:0043248)3.61153988
30ATP hydrolysis coupled proton transport (GO:0015991)3.57027868
31energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.57027868
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54765288
33establishment of mitochondrion localization (GO:0051654)3.53843851
34regulation of glutamate receptor signaling pathway (GO:1900449)3.50553559
35ATP biosynthetic process (GO:0006754)3.41440746
36protein neddylation (GO:0045116)3.37169485
37startle response (GO:0001964)3.35680803
38regulation of mitochondrial translation (GO:0070129)3.34953128
39hydrogen ion transmembrane transport (GO:1902600)3.34757004
40respiratory chain complex IV assembly (GO:0008535)3.34031843
41establishment of integrated proviral latency (GO:0075713)3.33765329
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32671424
43positive regulation of synapse assembly (GO:0051965)3.30934278
44oxidative phosphorylation (GO:0006119)3.30524669
45catecholamine transport (GO:0051937)3.28093094
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.25656167
47cullin deneddylation (GO:0010388)3.23536830
48transferrin transport (GO:0033572)3.20861702
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.20673732
50regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19740530
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19684119
52neuron-neuron synaptic transmission (GO:0007270)3.18395871
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18162655
54neurotransmitter uptake (GO:0001504)3.17756306
55neuronal action potential propagation (GO:0019227)3.17702355
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.16611033
57regulation of protein kinase A signaling (GO:0010738)3.16558926
58protein localization to cilium (GO:0061512)3.15580714
59neurotransmitter-gated ion channel clustering (GO:0072578)3.13955905
60regulation of dopamine metabolic process (GO:0042053)3.12804025
61regulation of catecholamine metabolic process (GO:0042069)3.12804025
62cytochrome complex assembly (GO:0017004)3.12088026
63regulation of glutamate secretion (GO:0014048)3.11837510
64protein-cofactor linkage (GO:0018065)3.07685193
65synaptic transmission, glutamatergic (GO:0035249)3.05151062
66regulation of synaptic vesicle exocytosis (GO:2000300)3.04613577
67glutamate receptor signaling pathway (GO:0007215)3.02389920
68proton transport (GO:0015992)2.99807071
69behavioral response to nicotine (GO:0035095)2.98960955
70positive regulation of protein homodimerization activity (GO:0090073)2.98677526
71protein deneddylation (GO:0000338)2.97876766
72ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95130276
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92286980
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92286980
75hydrogen transport (GO:0006818)2.92076113
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91277392
77establishment of viral latency (GO:0019043)2.91267481
78aerobic respiration (GO:0009060)2.90908198
79protein targeting to mitochondrion (GO:0006626)2.90438279
80ferric iron transport (GO:0015682)2.89164542
81trivalent inorganic cation transport (GO:0072512)2.89164542
82neurotransmitter secretion (GO:0007269)2.88347483
83glutamate secretion (GO:0014047)2.87689386
84establishment of protein localization to mitochondrion (GO:0072655)2.87312015
85peptidyl-arginine omega-N-methylation (GO:0035247)2.87184330
86nonmotile primary cilium assembly (GO:0035058)2.84960221
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84469820
88de novo posttranslational protein folding (GO:0051084)2.83926902
89de novo protein folding (GO:0006458)2.83781433
90negative regulation of telomere maintenance (GO:0032205)2.83513151
91transmission of nerve impulse (GO:0019226)2.81571095
92iron-sulfur cluster assembly (GO:0016226)2.81438110
93metallo-sulfur cluster assembly (GO:0031163)2.81438110
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79836335
95response to histamine (GO:0034776)2.79396983
96regulation of synaptic vesicle transport (GO:1902803)2.78198659
97positive regulation of membrane potential (GO:0045838)2.76906467
98water-soluble vitamin biosynthetic process (GO:0042364)2.75897340
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75707269
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74610109
101striatum development (GO:0021756)2.74245023
102positive regulation of synaptic transmission, GABAergic (GO:0032230)2.72138414
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.71852223
104termination of RNA polymerase III transcription (GO:0006386)2.71852223
105regulation of cilium movement (GO:0003352)2.71635934
106opioid receptor signaling pathway (GO:0038003)2.71220281
107long-term synaptic potentiation (GO:0060291)2.70734999
108peptidyl-arginine N-methylation (GO:0035246)2.70500722
109peptidyl-arginine methylation (GO:0018216)2.70500722
110GTP biosynthetic process (GO:0006183)2.70410138
111regulation of oxidative phosphorylation (GO:0002082)2.70209113
112positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68927576
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68790334
114negative regulation of neurotransmitter transport (GO:0051589)2.67624460
115histone arginine methylation (GO:0034969)2.66306650
116neurofilament cytoskeleton organization (GO:0060052)2.66289632
117regulation of cellular amino acid metabolic process (GO:0006521)2.65831190
118protein localization to mitochondrion (GO:0070585)2.65528680
119regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.64848996
120regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.64848996
121mannosylation (GO:0097502)2.64603730
122protein polyglutamylation (GO:0018095)2.63727410
123pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63235514
124neurotransmitter transport (GO:0006836)2.63015931
125positive regulation of neurotransmitter transport (GO:0051590)2.61904595
126spliceosomal snRNP assembly (GO:0000387)2.61086957
127regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60159756
128dendrite development (GO:0016358)2.60061628
129regulation of respiratory system process (GO:0044065)2.59147299
130intraciliary transport (GO:0042073)2.58819236
131cholesterol biosynthetic process (GO:0006695)2.57790346
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57619708
133nucleoside triphosphate biosynthetic process (GO:0009142)2.57263108
134ubiquinone metabolic process (GO:0006743)2.57194486
135DNA double-strand break processing (GO:0000729)2.55551741
136platelet dense granule organization (GO:0060155)2.55018368
137regulation of mitochondrial fission (GO:0090140)2.54298706
138retinal ganglion cell axon guidance (GO:0031290)2.53786459
139regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53441847
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53393591
1417-methylguanosine mRNA capping (GO:0006370)2.52094031
142guanosine-containing compound biosynthetic process (GO:1901070)2.51356825
143organelle disassembly (GO:1903008)2.50771162
144ribonucleoprotein complex disassembly (GO:0032988)2.50367618
145DNA integration (GO:0015074)2.50243277
146substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.47822159
147substrate-independent telencephalic tangential migration (GO:0021826)2.47822159
148histone H2A acetylation (GO:0043968)2.47660955
149sterol biosynthetic process (GO:0016126)2.46788981
150axonal fasciculation (GO:0007413)2.44597512
1517-methylguanosine RNA capping (GO:0009452)2.44513002
152RNA capping (GO:0036260)2.44513002
153establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43656377
154mitochondrion transport along microtubule (GO:0047497)2.43656377
155anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42327729
156negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.41844643
157negative regulation of ligase activity (GO:0051352)2.41844643
158anterograde synaptic vesicle transport (GO:0048490)2.41724720
159gamma-aminobutyric acid transport (GO:0015812)2.41370629
160DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.39140077
161regulation of helicase activity (GO:0051095)2.37515733
162ubiquinone biosynthetic process (GO:0006744)2.36740653
163neuron recognition (GO:0008038)2.35849151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.31077127
2GBX2_23144817_ChIP-Seq_PC3_Human3.78819617
3TAF15_26573619_Chip-Seq_HEK293_Human3.24502221
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85826585
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73732253
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62256778
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54780419
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.49395028
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43004458
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.41842593
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39031909
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38570814
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36754176
14ELK1_19687146_ChIP-ChIP_HELA_Human2.25818327
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24314240
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19820730
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14323887
18REST_21632747_ChIP-Seq_MESCs_Mouse2.10867055
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10657833
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07200732
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04602362
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.97477372
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96458130
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96136533
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95812483
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92804946
27* GABP_19822575_ChIP-Seq_HepG2_Human1.91804967
28FUS_26573619_Chip-Seq_HEK293_Human1.89635379
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88751088
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.82298524
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.82269865
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82153945
33XRN2_22483619_ChIP-Seq_HELA_Human1.80050310
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78087361
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73956006
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69709549
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69012216
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67783681
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67325498
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64916377
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61889502
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61739055
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61136007
44* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59956609
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59611094
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58021513
47P300_19829295_ChIP-Seq_ESCs_Human1.57822135
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.56011532
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.51719358
50IGF1R_20145208_ChIP-Seq_DFB_Human1.51504629
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50558848
52* SRF_21415370_ChIP-Seq_HL-1_Mouse1.50025191
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.46355962
54VDR_22108803_ChIP-Seq_LS180_Human1.45798285
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44789641
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44205081
57IRF1_19129219_ChIP-ChIP_H3396_Human1.43619512
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42338577
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42166952
60RNF2_27304074_Chip-Seq_NSC_Mouse1.42126250
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40652565
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40652565
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40033743
64* MYC_18555785_ChIP-Seq_MESCs_Mouse1.40018658
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39740066
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39049417
67ZNF274_21170338_ChIP-Seq_K562_Hela1.38804932
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38178957
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38104406
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37099653
71EWS_26573619_Chip-Seq_HEK293_Human1.35907611
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35823562
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.34558301
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34078576
75VDR_23849224_ChIP-Seq_CD4+_Human1.33504927
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32583838
77ER_23166858_ChIP-Seq_MCF-7_Human1.30425525
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.29043249
79SMAD4_21799915_ChIP-Seq_A2780_Human1.27904250
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27502000
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25621781
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25435029
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23510485
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21779840
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.21301472
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21180176
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19949289
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.18862362
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18789530
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17185810
91* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16715747
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16303351
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14298377
94JUN_21703547_ChIP-Seq_K562_Human1.14267739
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.14191301
96AR_21572438_ChIP-Seq_LNCaP_Human1.13855356
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13483951
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13331936
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13239373
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12717088
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12181347
102FOXP3_21729870_ChIP-Seq_TREG_Human1.08550270
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07907241
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.07810422
105TP53_22573176_ChIP-Seq_HFKS_Human1.07605436
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07520993
107* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05822798
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05340776
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05086509
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.04836948
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04195746
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03780281
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03594834
114NANOG_16153702_ChIP-ChIP_HESCs_Human1.01912496
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01100619
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.00149631
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00011329
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98221962
119DCP1A_22483619_ChIP-Seq_HELA_Human0.96861255
120AR_25329375_ChIP-Seq_VCAP_Human0.96487025
121TTF2_22483619_ChIP-Seq_HELA_Human0.95929403
122MYC_18940864_ChIP-ChIP_HL60_Human0.93915547
123KDM5A_27292631_Chip-Seq_BREAST_Human0.93056013
124REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92272118
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92064798
126SOX9_26525672_Chip-Seq_HEART_Mouse0.92020950
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90952760
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90663823
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88393378
130* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88233947
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87852147
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87251063
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.86372480
134PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86043303
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85041953
136* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83753343
137NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78194549
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74747109
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74462109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.31677683
2MP0001529_abnormal_vocalization3.45173118
3MP0004859_abnormal_synaptic_plasticity3.40117381
4MP0001968_abnormal_touch/_nociception3.19455795
5MP0003635_abnormal_synaptic_transmissio3.12340087
6MP0009745_abnormal_behavioral_response3.02058355
7MP0002736_abnormal_nociception_after3.01449246
8MP0006276_abnormal_autonomic_nervous2.85823906
9MP0002064_seizures2.77141709
10MP0009046_muscle_twitch2.73184671
11MP0002272_abnormal_nervous_system2.66335071
12MP0001905_abnormal_dopamine_level2.66140603
13MP0002572_abnormal_emotion/affect_behav2.55937631
14MP0002063_abnormal_learning/memory/cond2.53591885
15MP0004270_analgesia2.44071263
16MP0003122_maternal_imprinting2.34215485
17MP0001501_abnormal_sleep_pattern2.33106167
18MP0002735_abnormal_chemical_nociception2.27273579
19MP0004142_abnormal_muscle_tone2.26173758
20MP0002734_abnormal_mechanical_nocicepti2.26063798
21MP0001188_hyperpigmentation2.24423061
22MP0002102_abnormal_ear_morphology2.24237468
23MP0005646_abnormal_pituitary_gland2.23744950
24MP0005423_abnormal_somatic_nervous2.22679944
25MP0009379_abnormal_foot_pigmentation2.17489242
26MP0001440_abnormal_grooming_behavior2.04999310
27MP0005645_abnormal_hypothalamus_physiol2.04098926
28MP0006292_abnormal_olfactory_placode2.02124353
29MP0001486_abnormal_startle_reflex2.01353908
30MP0002822_catalepsy1.99494170
31MP0008058_abnormal_DNA_repair1.98920307
32MP0002067_abnormal_sensory_capabilities1.97683948
33MP0002733_abnormal_thermal_nociception1.87855848
34MP0001984_abnormal_olfaction1.86922557
35MP0001970_abnormal_pain_threshold1.84574341
36MP0004924_abnormal_behavior1.82136017
37MP0005386_behavior/neurological_phenoty1.82136017
38MP0005409_darkened_coat_color1.74176501
39MP0002653_abnormal_ependyma_morphology1.72323488
40MP0002557_abnormal_social/conspecific_i1.71013769
41MP0004133_heterotaxia1.64982620
42MP0002184_abnormal_innervation1.64232646
43MP0001986_abnormal_taste_sensitivity1.56068681
44MP0003787_abnormal_imprinting1.55268185
45MP0008877_abnormal_DNA_methylation1.54372961
46MP0002234_abnormal_pharynx_morphology1.51492852
47MP0005084_abnormal_gallbladder_morpholo1.49536124
48MP0002876_abnormal_thyroid_physiology1.41455116
49MP0000049_abnormal_middle_ear1.38477856
50MP0005253_abnormal_eye_physiology1.37321121
51MP0003693_abnormal_embryo_hatching1.36163122
52MP0003011_delayed_dark_adaptation1.33815547
53MP0003890_abnormal_embryonic-extraembry1.31748113
54MP0004147_increased_porphyrin_level1.31298532
55MP0003718_maternal_effect1.30995120
56MP0008569_lethality_at_weaning1.29326921
57MP0003879_abnormal_hair_cell1.28605281
58MP0000778_abnormal_nervous_system1.28419410
59MP0002837_dystrophic_cardiac_calcinosis1.27006591
60MP0008872_abnormal_physiological_respon1.26218733
61MP0001293_anophthalmia1.25715038
62MP0001502_abnormal_circadian_rhythm1.23349890
63MP0006035_abnormal_mitochondrial_morpho1.22772915
64MP0000647_abnormal_sebaceous_gland1.22519393
65MP0006036_abnormal_mitochondrial_physio1.21269910
66MP0005187_abnormal_penis_morphology1.20495182
67MP0008932_abnormal_embryonic_tissue1.19807889
68MP0002066_abnormal_motor_capabilities/c1.19694554
69MP0000631_abnormal_neuroendocrine_gland1.18461690
70MP0008995_early_reproductive_senescence1.13856128
71MP0004811_abnormal_neuron_physiology1.13599914
72MP0003121_genomic_imprinting1.11458423
73MP0002882_abnormal_neuron_morphology1.07403221
74MP0000566_synostosis1.07306650
75MP0005394_taste/olfaction_phenotype1.04950068
76MP0005499_abnormal_olfactory_system1.04950068
77MP0000955_abnormal_spinal_cord1.04633141
78MP0003861_abnormal_nervous_system1.01904800
79MP0001299_abnormal_eye_distance/1.01050473
80MP0003315_abnormal_perineum_morphology1.00124000
81MP0002233_abnormal_nose_morphology1.00050358
82MP0001963_abnormal_hearing_physiology0.99938770
83MP0003123_paternal_imprinting0.98807567
84MP0004885_abnormal_endolymph0.98471356
85MP0003937_abnormal_limbs/digits/tail_de0.96764158
86MP0005551_abnormal_eye_electrophysiolog0.96565404
87MP0006072_abnormal_retinal_apoptosis0.95767799
88MP0005379_endocrine/exocrine_gland_phen0.95478099
89MP0005171_absent_coat_pigmentation0.94530221
90MP0004742_abnormal_vestibular_system0.93372692
91MP0003786_premature_aging0.92858883
92MP0002229_neurodegeneration0.92586441
93MP0001286_abnormal_eye_development0.92009216
94MP0002909_abnormal_adrenal_gland0.90732199
95MP0002638_abnormal_pupillary_reflex0.90395664
96MP0003186_abnormal_redox_activity0.89288350
97MP0003119_abnormal_digestive_system0.89060843
98MP0000358_abnormal_cell_content/0.87937631
99MP0010386_abnormal_urinary_bladder0.87750444
100MP0001664_abnormal_digestion0.85764416
101MP0003567_abnormal_fetal_cardiomyocyte0.85533327
102MP0003938_abnormal_ear_development0.85102177
103MP0003329_amyloid_beta_deposits0.84695880
104MP0005391_vision/eye_phenotype0.84465247
105MP0002751_abnormal_autonomic_nervous0.84164321
106MP0000751_myopathy0.82673155
107MP0004145_abnormal_muscle_electrophysio0.81893795
108MP0003755_abnormal_palate_morphology0.81160968
109MP0000015_abnormal_ear_pigmentation0.80673772
110MP0005195_abnormal_posterior_eye0.80137544
111MP0010094_abnormal_chromosome_stability0.79267323
112MP0002752_abnormal_somatic_nervous0.78510813
113MP0002152_abnormal_brain_morphology0.77476764
114MP0003633_abnormal_nervous_system0.76835040
115MP0005075_abnormal_melanosome_morpholog0.76078684
116MP0008789_abnormal_olfactory_epithelium0.76050947
117MP0009697_abnormal_copulation0.75410620
118MP0002210_abnormal_sex_determination0.75287805
119MP0002069_abnormal_eating/drinking_beha0.72573070
120MP0002163_abnormal_gland_morphology0.70278393
121MP0003631_nervous_system_phenotype0.69977001
122MP0000026_abnormal_inner_ear0.68336266
123MP0000372_irregular_coat_pigmentation0.68089754
124MP0004085_abnormal_heartbeat0.67311817
125MP0005535_abnormal_body_temperature0.66029705
126MP0004215_abnormal_myocardial_fiber0.65426403
127MP0009780_abnormal_chondrocyte_physiolo0.58940948
128MP0005410_abnormal_fertilization0.57415353
129MP0003136_yellow_coat_color0.57281985
130MP0008874_decreased_physiological_sensi0.56056534
131MP0002160_abnormal_reproductive_system0.55019853
132MP0003646_muscle_fatigue0.51866155
133MP0000013_abnormal_adipose_tissue0.51337182
134MP0001485_abnormal_pinna_reflex0.50790504
135MP0002938_white_spotting0.50526785
136MP0003956_abnormal_body_size0.48811138

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.66222665
2Abnormal mitochondria in muscle tissue (HP:0008316)5.25637988
3Focal motor seizures (HP:0011153)5.21192039
4Mitochondrial inheritance (HP:0001427)5.19720461
5Hepatocellular necrosis (HP:0001404)4.87870161
6Progressive macrocephaly (HP:0004481)4.76250221
7Increased CSF lactate (HP:0002490)4.51063874
8Acute encephalopathy (HP:0006846)4.34684653
9Myokymia (HP:0002411)3.95781528
10Hepatic necrosis (HP:0002605)3.69775404
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.69418198
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.69418198
13Increased hepatocellular lipid droplets (HP:0006565)3.58128199
14Abnormal hair whorl (HP:0010721)3.49263528
15Atonic seizures (HP:0010819)3.45408694
16Pheochromocytoma (HP:0002666)3.36109743
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35411272
18Neuroendocrine neoplasm (HP:0100634)3.32359475
19Hypothermia (HP:0002045)3.32316389
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.31380283
21Abnormality of the labia minora (HP:0012880)3.25730222
22Epileptic encephalopathy (HP:0200134)3.24110286
23Visual hallucinations (HP:0002367)3.20652348
24Lactic acidosis (HP:0003128)3.19363498
25Leukodystrophy (HP:0002415)3.18996323
26Medial flaring of the eyebrow (HP:0010747)3.15159811
27Optic disc pallor (HP:0000543)3.13479633
28Gait imbalance (HP:0002141)3.10714825
29Hyperventilation (HP:0002883)3.10007361
303-Methylglutaconic aciduria (HP:0003535)3.08624393
31Increased serum lactate (HP:0002151)3.05477373
32Focal seizures (HP:0007359)3.05046552
33Renal Fanconi syndrome (HP:0001994)3.04017065
34Limb dystonia (HP:0002451)3.03551632
35Lissencephaly (HP:0001339)3.03433255
36Febrile seizures (HP:0002373)2.97113558
37Exercise intolerance (HP:0003546)2.96051906
38Lipid accumulation in hepatocytes (HP:0006561)2.93865079
39Congenital primary aphakia (HP:0007707)2.90791843
40Cortical dysplasia (HP:0002539)2.87802007
41Increased intramyocellular lipid droplets (HP:0012240)2.85606892
42Respiratory failure (HP:0002878)2.80176564
43Nephrogenic diabetes insipidus (HP:0009806)2.78067081
44Poor suck (HP:0002033)2.76619771
45Abnormality of glycolysis (HP:0004366)2.69479911
46Increased serum pyruvate (HP:0003542)2.69479911
47Cerebral edema (HP:0002181)2.68872511
48Progressive inability to walk (HP:0002505)2.65599268
49Absence seizures (HP:0002121)2.64124054
50Hyperglycinemia (HP:0002154)2.60563619
51Anxiety (HP:0000739)2.58258589
52Broad-based gait (HP:0002136)2.51350280
53Dialeptic seizures (HP:0011146)2.50552010
54Degeneration of anterior horn cells (HP:0002398)2.47944043
55Abnormality of the anterior horn cell (HP:0006802)2.47944043
56Abnormality of cells of the erythroid lineage (HP:0012130)2.46206607
57Abnormal number of erythroid precursors (HP:0012131)2.45961569
58Emotional lability (HP:0000712)2.44915039
59Colon cancer (HP:0003003)2.39112440
60Progressive cerebellar ataxia (HP:0002073)2.33114269
61Pancreatic cysts (HP:0001737)2.32085513
62Esotropia (HP:0000565)2.30776768
63Polyphagia (HP:0002591)2.30553599
64Methylmalonic acidemia (HP:0002912)2.26088175
65Type II lissencephaly (HP:0007260)2.24608029
66Pachygyria (HP:0001302)2.24421311
67Aplasia/Hypoplasia of the brainstem (HP:0007362)2.22667633
68Hypoplasia of the brainstem (HP:0002365)2.22667633
69Cerebral hypomyelination (HP:0006808)2.20122503
70CNS hypomyelination (HP:0003429)2.19860479
71Vaginal atresia (HP:0000148)2.16638308
72Genital tract atresia (HP:0001827)2.16223959
73Gaze-evoked nystagmus (HP:0000640)2.15898558
74Increased muscle lipid content (HP:0009058)2.13618452
75Progressive external ophthalmoplegia (HP:0000590)2.12871594
76Respiratory difficulties (HP:0002880)2.12193972
77Generalized tonic-clonic seizures (HP:0002069)2.12065163
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.11846503
79Inability to walk (HP:0002540)2.11410554
80Microvesicular hepatic steatosis (HP:0001414)2.10709404
81X-linked dominant inheritance (HP:0001423)2.09991899
82Exertional dyspnea (HP:0002875)2.09453251
83Retinal dysplasia (HP:0007973)2.08098265
84Poor coordination (HP:0002370)2.06038654
85CNS demyelination (HP:0007305)2.04873094
86Sclerocornea (HP:0000647)2.03842327
87Abnormality of the heme biosynthetic pathway (HP:0010472)2.02799579
88Abnormality of renal resorption (HP:0011038)2.00555237
89Shoulder girdle muscle weakness (HP:0003547)1.99833808
90Pancreatic fibrosis (HP:0100732)1.99171621
91Truncal ataxia (HP:0002078)1.98210814
92Protruding tongue (HP:0010808)1.97030992
93Delusions (HP:0000746)1.96070126
94Neoplasm of the peripheral nervous system (HP:0100007)1.92540769
95Hypoplastic pelvis (HP:0008839)1.90629909
96Specific learning disability (HP:0001328)1.90093853
97Split foot (HP:0001839)1.89723459
98Abnormal eating behavior (HP:0100738)1.89376777
99Methylmalonic aciduria (HP:0012120)1.89238614
100Abnormality of the hip-girdle musculature (HP:0001445)1.88370232
101Abnormality of the musculature of the pelvis (HP:0001469)1.88370232
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88019692
103Abnormal protein N-linked glycosylation (HP:0012347)1.88019692
104Abnormal protein glycosylation (HP:0012346)1.88019692
105Abnormal glycosylation (HP:0012345)1.88019692
106Failure to thrive in infancy (HP:0001531)1.87086287
107Severe visual impairment (HP:0001141)1.86554881
108Intestinal atresia (HP:0011100)1.85010372
109Type I transferrin isoform profile (HP:0003642)1.83883641
110Peripheral hypomyelination (HP:0007182)1.82838985
111Abnormality of alanine metabolism (HP:0010916)1.82626156
112Hyperalaninemia (HP:0003348)1.82626156
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82626156
114Muscular hypotonia of the trunk (HP:0008936)1.82264010
115Aplasia/hypoplasia of the uterus (HP:0008684)1.82005316
116Broad foot (HP:0001769)1.81153258
117Nephronophthisis (HP:0000090)1.80001079
118Amyotrophic lateral sclerosis (HP:0007354)1.79197858
119Decreased testicular size (HP:0008734)1.78675952
120Unsteady gait (HP:0002317)1.78373283
121Oligomenorrhea (HP:0000876)1.78368542
122Upper limb muscle weakness (HP:0003484)1.77229436
123Amblyopia (HP:0000646)1.77046951
124True hermaphroditism (HP:0010459)1.76738571
125Polymicrogyria (HP:0002126)1.76714271
126Ragged-red muscle fibers (HP:0003200)1.76100555
127Occipital encephalocele (HP:0002085)1.74412413
128Psychosis (HP:0000709)1.74213819
129Postnatal microcephaly (HP:0005484)1.73309636
130Pendular nystagmus (HP:0012043)1.73116260
131Hypsarrhythmia (HP:0002521)1.72878245
132Aplastic anemia (HP:0001915)1.72737060
133Postaxial hand polydactyly (HP:0001162)1.72652863
134Abnormality of midbrain morphology (HP:0002418)1.72113379
135Molar tooth sign on MRI (HP:0002419)1.72113379
136Drooling (HP:0002307)1.71866575
137Excessive salivation (HP:0003781)1.71866575
138Preaxial hand polydactyly (HP:0001177)1.71602016
139Optic nerve hypoplasia (HP:0000609)1.70061949
140Medulloblastoma (HP:0002885)1.70058084
141Epileptiform EEG discharges (HP:0011182)1.69997835
142Synostosis involving the elbow (HP:0003938)1.69078995
143Humeroradial synostosis (HP:0003041)1.69078995
144Abnormal pupillary function (HP:0007686)1.67487186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.06508209
2CASK4.54476494
3MAP4K23.26308968
4NTRK33.18867145
5TRIM282.94371945
6MAP2K72.81920658
7VRK22.78444864
8CDK192.58765915
9NME12.55833825
10STK162.48818037
11TNIK2.35955350
12TSSK62.33221218
13MAP3K42.14287756
14SRPK12.01723278
15TESK11.96562435
16BCKDK1.91110494
17PNCK1.88881195
18SIK31.83750751
19DAPK11.80595670
20CSNK1A1L1.75717958
21VRK11.72381186
22MUSK1.70548778
23MARK11.69014300
24ZAK1.66688821
25MINK11.62991464
26ERBB31.62240000
27EPHA41.57545994
28GRK51.57523379
29DYRK31.55375143
30MAPK131.54552508
31ADRBK21.47972223
32MYLK1.45625550
33GRK71.44820501
34NEK11.43601789
35OXSR11.43013235
36CCNB11.42929333
37ARAF1.38956778
38PLK21.36666672
39MAPKAPK51.35045432
40MAP2K41.33977190
41MAP3K91.22185459
42NUAK11.19541822
43RPS6KA41.15106946
44BUB11.07586208
45CAMK2B1.04642481
46UHMK11.04603243
47PIM21.03193884
48PAK31.02565855
49PRKCG0.99484488
50AKT30.97950380
51RIPK40.97404448
52FES0.97028401
53BCR0.95772489
54EPHB20.95362523
55TNK20.95237041
56CAMK2A0.95025614
57CSNK1G30.94255459
58PRPF4B0.92671118
59NTRK20.91185435
60BMPR1B0.87571773
61BMPR20.87409453
62WNK30.84999639
63CSNK1G20.83082500
64CDC70.82969843
65EIF2AK30.82771528
66EIF2AK10.81521749
67CDK50.80430446
68CDK80.76167252
69TLK10.75715996
70PAK60.74887079
71DAPK20.74482144
72BRAF0.74088629
73RPS6KA50.73901024
74PLK10.73403210
75AURKA0.72815298
76ADRBK10.69918122
77PKN10.68959768
78DYRK1B0.68890232
79CAMK10.68141162
80PBK0.66958208
81PLK30.66188281
82CDK180.65824160
83MAP2K60.64563168
84CAMKK20.63243210
85MKNK20.61050725
86FLT30.60011175
87CAMK2D0.58995213
88STK390.58874215
89CDK140.58751922
90MKNK10.57900995
91SGK2230.56739235
92SGK4940.56739235
93CDK150.55026044
94MST40.54869346
95BRSK10.52920687
96EPHA30.52055497
97NEK60.50592434
98CDK11A0.50432305
99SYK0.49893473
100PAK40.49738654
101CAMK2G0.49245246
102GRK10.49241116
103ATR0.49087016
104LMTK20.48107662
105CSNK1G10.47810886
106SGK20.47074531
107TXK0.45879631
108AURKB0.45712568
109CSNK1A10.45487306
110CHEK20.44545013
111PRKCE0.43847640
112CDK30.43558503
113PRKACA0.43079411
114YES10.42970383
115INSRR0.42139720
116PASK0.41732957
117CSNK1E0.41582941
118LIMK10.41477720
119PLK40.41416949
120WEE10.41321715
121DYRK1A0.41149588
122GRK60.40264820
123TESK20.40241554
124CSNK2A10.39720224
125CSNK2A20.39126507
126NME20.37474438
127ROCK20.36926255
128DAPK30.36069829
129MAPK40.35816718
130PRKCI0.35188921
131ERBB40.34382322
132MAPK150.34262468
133RPS6KB10.34216517
134PDK40.33406009
135PDK30.33406009
136MAP3K110.31998760
137PHKG20.31552032
138PHKG10.31552032
139PINK10.30461474
140DYRK20.29978470

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.06758291
2Parkinsons disease_Homo sapiens_hsa050124.36036761
3Nicotine addiction_Homo sapiens_hsa050333.48853724
4Alzheimers disease_Homo sapiens_hsa050103.28712408
5Huntingtons disease_Homo sapiens_hsa050163.03582053
6Synaptic vesicle cycle_Homo sapiens_hsa047212.96800588
7Collecting duct acid secretion_Homo sapiens_hsa049662.93008702
8Proteasome_Homo sapiens_hsa030502.72177195
9Ribosome_Homo sapiens_hsa030102.45013885
10Steroid biosynthesis_Homo sapiens_hsa001002.23704407
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.21153848
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19711884
13Cardiac muscle contraction_Homo sapiens_hsa042602.12115917
14RNA polymerase_Homo sapiens_hsa030202.09494836
15Protein export_Homo sapiens_hsa030602.08856909
16Olfactory transduction_Homo sapiens_hsa047401.94205251
17Amphetamine addiction_Homo sapiens_hsa050311.92681600
18Vibrio cholerae infection_Homo sapiens_hsa051101.90268458
19GABAergic synapse_Homo sapiens_hsa047271.87988002
20Circadian entrainment_Homo sapiens_hsa047131.78279340
21Morphine addiction_Homo sapiens_hsa050321.74841574
22Serotonergic synapse_Homo sapiens_hsa047261.65415045
23Taste transduction_Homo sapiens_hsa047421.64443656
24Long-term potentiation_Homo sapiens_hsa047201.61025675
25Glutamatergic synapse_Homo sapiens_hsa047241.55758981
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55078798
27Dopaminergic synapse_Homo sapiens_hsa047281.52090991
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49132919
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45396497
30Fanconi anemia pathway_Homo sapiens_hsa034601.43423516
31Butanoate metabolism_Homo sapiens_hsa006501.33736126
32Propanoate metabolism_Homo sapiens_hsa006401.33222295
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31513276
34Cocaine addiction_Homo sapiens_hsa050301.27153763
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26506794
36Phototransduction_Homo sapiens_hsa047441.21467389
37Long-term depression_Homo sapiens_hsa047301.20063808
38Salivary secretion_Homo sapiens_hsa049701.19437563
39Biosynthesis of amino acids_Homo sapiens_hsa012301.18779945
40Calcium signaling pathway_Homo sapiens_hsa040201.17601485
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09173682
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07740173
43Renin secretion_Homo sapiens_hsa049241.04423707
44Insulin secretion_Homo sapiens_hsa049111.03886393
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02960477
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01660595
47Cholinergic synapse_Homo sapiens_hsa047251.00261731
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98621879
49Pyrimidine metabolism_Homo sapiens_hsa002400.98443956
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93754954
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93721973
52Peroxisome_Homo sapiens_hsa041460.93009619
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92619617
54Purine metabolism_Homo sapiens_hsa002300.91328503
55Carbon metabolism_Homo sapiens_hsa012000.90339204
56Selenocompound metabolism_Homo sapiens_hsa004500.90096091
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89742875
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89211079
59Rheumatoid arthritis_Homo sapiens_hsa053230.86833126
60One carbon pool by folate_Homo sapiens_hsa006700.83174737
61Gastric acid secretion_Homo sapiens_hsa049710.81884985
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81402649
63Spliceosome_Homo sapiens_hsa030400.79567544
64Pyruvate metabolism_Homo sapiens_hsa006200.78669639
65Folate biosynthesis_Homo sapiens_hsa007900.78483359
66Fatty acid elongation_Homo sapiens_hsa000620.76657524
67Oxytocin signaling pathway_Homo sapiens_hsa049210.76224633
68Glutathione metabolism_Homo sapiens_hsa004800.76002227
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75573736
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74093969
71Gap junction_Homo sapiens_hsa045400.72680504
72RNA degradation_Homo sapiens_hsa030180.70309152
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68206328
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66268869
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63709439
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63616929
77Alcoholism_Homo sapiens_hsa050340.63609288
78Sulfur relay system_Homo sapiens_hsa041220.62265013
79mRNA surveillance pathway_Homo sapiens_hsa030150.61827638
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60973978
81Vitamin B6 metabolism_Homo sapiens_hsa007500.58455867
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57790727
83Type I diabetes mellitus_Homo sapiens_hsa049400.57334054
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57022616
85Basal transcription factors_Homo sapiens_hsa030220.56546233
86Oocyte meiosis_Homo sapiens_hsa041140.56004122
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54916656
88Mismatch repair_Homo sapiens_hsa034300.54492876
89Metabolic pathways_Homo sapiens_hsa011000.53729001
90Nucleotide excision repair_Homo sapiens_hsa034200.53014456
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52494720
92DNA replication_Homo sapiens_hsa030300.50706380
93Cell cycle_Homo sapiens_hsa041100.50092297
94Hippo signaling pathway_Homo sapiens_hsa043900.49340074
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47331999
96Sulfur metabolism_Homo sapiens_hsa009200.46774320
97Fatty acid metabolism_Homo sapiens_hsa012120.45722904
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.44803446
99Hedgehog signaling pathway_Homo sapiens_hsa043400.44091690
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43728577
101Phagosome_Homo sapiens_hsa041450.43383252
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41895716
103Arginine and proline metabolism_Homo sapiens_hsa003300.41779221
104N-Glycan biosynthesis_Homo sapiens_hsa005100.41590199
105GnRH signaling pathway_Homo sapiens_hsa049120.41201824
106beta-Alanine metabolism_Homo sapiens_hsa004100.40119963
107cAMP signaling pathway_Homo sapiens_hsa040240.39356403
108Basal cell carcinoma_Homo sapiens_hsa052170.38948092
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35944263
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33908988
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.33854336
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32293696
113African trypanosomiasis_Homo sapiens_hsa051430.31500626
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30929146
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29216992
116Homologous recombination_Homo sapiens_hsa034400.27615569
117p53 signaling pathway_Homo sapiens_hsa041150.27532144
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.27124611
119Circadian rhythm_Homo sapiens_hsa047100.26689857
120RNA transport_Homo sapiens_hsa030130.26170391
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24905042
122Axon guidance_Homo sapiens_hsa043600.24764925
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24588334
124Pancreatic secretion_Homo sapiens_hsa049720.23878677
125Melanogenesis_Homo sapiens_hsa049160.23659305
126Non-homologous end-joining_Homo sapiens_hsa034500.22527368
127Estrogen signaling pathway_Homo sapiens_hsa049150.18302809
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15384925
129Base excision repair_Homo sapiens_hsa034100.15128459
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15048859
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13647784
132Thyroid hormone synthesis_Homo sapiens_hsa049180.13262224
133Regulation of autophagy_Homo sapiens_hsa041400.12707010
134Ether lipid metabolism_Homo sapiens_hsa005650.11759605
135Glucagon signaling pathway_Homo sapiens_hsa049220.10355004
136Tyrosine metabolism_Homo sapiens_hsa003500.09691166
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09248150

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