DTD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.79051725
2DNA deamination (GO:0045006)5.43839011
3ribosomal small subunit assembly (GO:0000028)4.80364916
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.47059082
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.47059082
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.38588184
7DNA double-strand break processing (GO:0000729)4.30267961
8protein-cofactor linkage (GO:0018065)4.14396923
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05793436
10telomere maintenance via semi-conservative replication (GO:0032201)4.03082695
11oxidative phosphorylation (GO:0006119)3.94931813
12DNA strand elongation involved in DNA replication (GO:0006271)3.92598091
13regulation of mitochondrial translation (GO:0070129)3.89235477
14protein complex biogenesis (GO:0070271)3.89052471
15NADH dehydrogenase complex assembly (GO:0010257)3.86373425
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86373425
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.86373425
18behavioral response to nicotine (GO:0035095)3.84822078
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.84465099
20respiratory chain complex IV assembly (GO:0008535)3.82764322
21L-fucose catabolic process (GO:0042355)3.81565460
22fucose catabolic process (GO:0019317)3.81565460
23L-fucose metabolic process (GO:0042354)3.81565460
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78667314
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76506013
26ATP synthesis coupled proton transport (GO:0015986)3.76506013
27cullin deneddylation (GO:0010388)3.74566416
28water-soluble vitamin biosynthetic process (GO:0042364)3.73240394
29purine nucleobase biosynthetic process (GO:0009113)3.73014597
30DNA strand elongation (GO:0022616)3.72355911
31protein deneddylation (GO:0000338)3.72111261
32mitochondrial respiratory chain complex assembly (GO:0033108)3.70985339
33regulation of cellular amino acid metabolic process (GO:0006521)3.68469577
34telomere maintenance via recombination (GO:0000722)3.65478339
35nucleobase biosynthetic process (GO:0046112)3.63469100
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63227997
37pseudouridine synthesis (GO:0001522)3.62069601
38response to pheromone (GO:0019236)3.59220437
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.57287486
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.57287486
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.57263759
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.57263759
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.57263759
44cysteine metabolic process (GO:0006534)3.56926643
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56167380
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55798995
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.54769215
48mitochondrial RNA metabolic process (GO:0000959)3.53510428
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50199602
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47483108
51negative regulation of ligase activity (GO:0051352)3.47483108
52iron-sulfur cluster assembly (GO:0016226)3.47263769
53metallo-sulfur cluster assembly (GO:0031163)3.47263769
54signal transduction involved in DNA damage checkpoint (GO:0072422)3.45857551
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45857551
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45039434
57formation of translation preinitiation complex (GO:0001731)3.44838407
58DNA replication initiation (GO:0006270)3.44576181
59cotranslational protein targeting to membrane (GO:0006613)3.44512704
607-methylguanosine mRNA capping (GO:0006370)3.43553213
61maturation of SSU-rRNA (GO:0030490)3.41304971
62folic acid-containing compound biosynthetic process (GO:0009396)3.40448955
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.40301821
64peptidyl-histidine modification (GO:0018202)3.38869112
65L-methionine salvage (GO:0071267)3.38867437
66L-methionine biosynthetic process (GO:0071265)3.38867437
67amino acid salvage (GO:0043102)3.38867437
68termination of RNA polymerase III transcription (GO:0006386)3.38154652
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.38154652
70RNA capping (GO:0036260)3.37835894
717-methylguanosine RNA capping (GO:0009452)3.37835894
72protein targeting to ER (GO:0045047)3.36706061
73translation (GO:0006412)3.35561280
74respiratory electron transport chain (GO:0022904)3.34255882
75CENP-A containing nucleosome assembly (GO:0034080)3.33739698
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33029182
77platelet dense granule organization (GO:0060155)3.32187456
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.31212265
79protein localization to endoplasmic reticulum (GO:0070972)3.31077574
80translational termination (GO:0006415)3.31031758
81viral transcription (GO:0019083)3.29713089
82maturation of 5.8S rRNA (GO:0000460)3.29595877
83sulfur amino acid catabolic process (GO:0000098)3.28355827
84ribosomal large subunit biogenesis (GO:0042273)3.28317902
85electron transport chain (GO:0022900)3.26560842
86ribosomal small subunit biogenesis (GO:0042274)3.26560640
87deoxyribose phosphate biosynthetic process (GO:0046385)3.26000884
882-deoxyribonucleotide biosynthetic process (GO:0009265)3.26000884
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24776484
90cytochrome complex assembly (GO:0017004)3.24682832
91transcription-coupled nucleotide-excision repair (GO:0006283)3.24536232
92negative regulation of DNA-dependent DNA replication (GO:2000104)3.23172538
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22748581
94deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.19579996
95chromatin remodeling at centromere (GO:0031055)3.19486812
96L-serine metabolic process (GO:0006563)3.18699842
97mitotic recombination (GO:0006312)3.18330269
98establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15321357
99replication fork processing (GO:0031297)3.14932867
100cellular component biogenesis (GO:0044085)3.14450477
101adenosine metabolic process (GO:0046085)3.12980858
102tRNA processing (GO:0008033)3.11368477
103DNA catabolic process, exonucleolytic (GO:0000738)3.10840814
104pteridine-containing compound biosynthetic process (GO:0042559)3.10174596
105ribonucleoprotein complex biogenesis (GO:0022613)3.10029390
106translational elongation (GO:0006414)3.08460472
107tRNA modification (GO:0006400)3.08176189
108telomere maintenance via telomere lengthening (GO:0010833)3.07703810
109deoxyribonucleotide biosynthetic process (GO:0009263)3.06900431
110guanosine-containing compound biosynthetic process (GO:1901070)3.06182647
111signal peptide processing (GO:0006465)3.05694043
112nucleotide-excision repair, DNA gap filling (GO:0006297)3.04674165
113rRNA modification (GO:0000154)3.04335413
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02239024
115GDP-mannose metabolic process (GO:0019673)3.01989317
116protein targeting to mitochondrion (GO:0006626)3.01383259
117ribosome biogenesis (GO:0042254)3.00667456
118establishment of protein localization to mitochondrion (GO:0072655)3.00607713
119resolution of meiotic recombination intermediates (GO:0000712)2.97604452
120IMP biosynthetic process (GO:0006188)2.96665566
121rRNA processing (GO:0006364)2.94643342
122positive regulation of ligase activity (GO:0051351)2.94105741
123spliceosomal snRNP assembly (GO:0000387)2.93744754
124GTP biosynthetic process (GO:0006183)2.93195876
125serine family amino acid catabolic process (GO:0009071)2.88974495
126tryptophan catabolic process (GO:0006569)2.88680323
127indole-containing compound catabolic process (GO:0042436)2.88680323
128indolalkylamine catabolic process (GO:0046218)2.88680323
129epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88618524
130sulfur amino acid biosynthetic process (GO:0000097)2.87659087
131recombinational repair (GO:0000725)2.87650906
132ubiquinone metabolic process (GO:0006743)2.86648238
133preassembly of GPI anchor in ER membrane (GO:0016254)2.84685755
134double-strand break repair via homologous recombination (GO:0000724)2.84171423
135branched-chain amino acid catabolic process (GO:0009083)2.81748454
136protein K11-linked deubiquitination (GO:0035871)2.78850842
137ubiquinone biosynthetic process (GO:0006744)2.77266160
138kynurenine metabolic process (GO:0070189)2.76361145
139neural tube formation (GO:0001841)2.71627572
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71286027
141protein prenylation (GO:0018342)2.69877495
142prenylation (GO:0097354)2.69877495
143methionine biosynthetic process (GO:0009086)2.67445434
144mannosylation (GO:0097502)2.66478555
145isoprenoid biosynthetic process (GO:0008299)2.66287166
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64143567
147negative regulation of telomere maintenance (GO:0032205)2.64135714
148cilium morphogenesis (GO:0060271)2.63951612
149reciprocal meiotic recombination (GO:0007131)2.61783414
150reciprocal DNA recombination (GO:0035825)2.61783414
151dopamine transport (GO:0015872)2.61636665
152tRNA metabolic process (GO:0006399)2.60947622
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58552560
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.58552560
155regulation of sarcomere organization (GO:0060297)2.55411231
156histone exchange (GO:0043486)2.55115168
157regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53834251
158regulation of mitotic spindle checkpoint (GO:1903504)2.53834251
159homocysteine metabolic process (GO:0050667)2.52652868
160DNA replication-dependent nucleosome organization (GO:0034723)2.50021210
161DNA replication-dependent nucleosome assembly (GO:0006335)2.50021210
162epithelial cilium movement (GO:0003351)2.49797145
163serine family amino acid biosynthetic process (GO:0009070)2.48172264
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47921822
165nonmotile primary cilium assembly (GO:0035058)2.47500889
166positive regulation of oligodendrocyte differentiation (GO:0048714)2.46858990
167attachment of spindle microtubules to kinetochore (GO:0008608)2.45176918
168tryptophan metabolic process (GO:0006568)2.44469503
169histone mRNA metabolic process (GO:0008334)2.44464712
170serine family amino acid metabolic process (GO:0009069)2.43753638
171indolalkylamine metabolic process (GO:0006586)2.43214662
172detection of light stimulus involved in sensory perception (GO:0050962)2.42655496
173detection of light stimulus involved in visual perception (GO:0050908)2.42655496
174GMP metabolic process (GO:0046037)2.38400037
175regulation of DNA endoreduplication (GO:0032875)2.36882344
176tRNA methylation (GO:0030488)2.35887019
177regulation of glucokinase activity (GO:0033131)2.35107361
178regulation of hexokinase activity (GO:1903299)2.35107361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12633153
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.63217776
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.05461791
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.96118938
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.94248232
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.79079472
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.76837754
8ZNF274_21170338_ChIP-Seq_K562_Hela3.68880625
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54910613
10VDR_22108803_ChIP-Seq_LS180_Human3.38947111
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.28020557
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.17601886
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.14530808
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11307709
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05024735
16IGF1R_20145208_ChIP-Seq_DFB_Human3.02742389
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92833761
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82271632
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.81047017
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71138648
21VDR_23849224_ChIP-Seq_CD4+_Human2.71034235
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.63191438
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.62650888
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54181209
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52909933
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.47868116
27GBX2_23144817_ChIP-Seq_PC3_Human2.46200442
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.44957891
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43943219
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.43758750
31FUS_26573619_Chip-Seq_HEK293_Human2.42325325
32FOXP3_21729870_ChIP-Seq_TREG_Human2.38181049
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35245666
34EWS_26573619_Chip-Seq_HEK293_Human2.32174179
35DCP1A_22483619_ChIP-Seq_HELA_Human2.32169229
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28177246
37XRN2_22483619_ChIP-Seq_HELA_Human2.25754727
38MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25376591
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23904085
40THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22782212
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14087772
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13515455
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11331344
44PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04852396
45TAF15_26573619_Chip-Seq_HEK293_Human2.04372470
46GABP_19822575_ChIP-Seq_HepG2_Human2.01037916
47ELK1_19687146_ChIP-ChIP_HELA_Human1.98037308
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97623408
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93348241
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89682187
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88864869
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.87219154
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87067208
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87065226
55P300_19829295_ChIP-Seq_ESCs_Human1.86617008
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78132416
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78105567
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78025796
59ER_23166858_ChIP-Seq_MCF-7_Human1.75506724
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73608836
61TTF2_22483619_ChIP-Seq_HELA_Human1.73304169
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71635965
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66610031
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65883984
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65443439
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60202810
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55605629
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54378485
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52230037
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51470751
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50195412
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46536483
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46434299
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45560639
75TP53_22573176_ChIP-Seq_HFKS_Human1.44675244
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44405346
77CBP_20019798_ChIP-Seq_JUKART_Human1.44387578
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44387578
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43585140
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43406983
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33764976
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33212936
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32939887
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.32228032
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31988029
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.31764101
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31437496
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29345271
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28612879
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27692678
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25578691
92SOX2_19829295_ChIP-Seq_ESCs_Human1.22166581
93NANOG_19829295_ChIP-Seq_ESCs_Human1.22166581
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22106597
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22031262
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21235216
97STAT3_23295773_ChIP-Seq_U87_Human1.21203253
98TCF4_22108803_ChIP-Seq_LS180_Human1.20973063
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20827360
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20511372
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20208149
102BCAT_22108803_ChIP-Seq_LS180_Human1.19814990
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.19579125
104SMAD4_21799915_ChIP-Seq_A2780_Human1.18796857
105CDX2_22108803_ChIP-Seq_LS180_Human1.18068062
106MYC_18940864_ChIP-ChIP_HL60_Human1.18050808
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17847585
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17490776
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17395343
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.17395343
111AR_20517297_ChIP-Seq_VCAP_Human1.16089570
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14373063
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13309593
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11920118
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11801234
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11714643
117KDM5A_27292631_Chip-Seq_BREAST_Human1.10711025
118CIITA_25753668_ChIP-Seq_RAJI_Human1.10556670
119AR_21909140_ChIP-Seq_LNCAP_Human1.10369801
120ELK1_22589737_ChIP-Seq_MCF10A_Human1.09904809
121AR_25329375_ChIP-Seq_VCAP_Human1.09590092
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09338140
123E2F1_21310950_ChIP-Seq_MCF-7_Human1.09190386
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07941122
125IRF1_19129219_ChIP-ChIP_H3396_Human1.07796974
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07364962
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07055146
128NCOR_22424771_ChIP-Seq_293T_Human1.07032376
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.05183211
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.04837649
131TFEB_21752829_ChIP-Seq_HELA_Human1.04490426
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04480511
133RUNX2_22187159_ChIP-Seq_PCA_Human1.04252451
134TCF4_23295773_ChIP-Seq_U87_Human1.03700362
135AR_21572438_ChIP-Seq_LNCaP_Human1.03424764
136SMAD3_21741376_ChIP-Seq_EPCs_Human1.02255188
137SPI1_23547873_ChIP-Seq_NB4_Human1.02073460
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.00448462
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99711430
140SOX17_20123909_ChIP-Seq_XEN_Mouse0.99020148
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98803174
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98466274
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98172555
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98024508
145P53_22387025_ChIP-Seq_ESCs_Mouse0.97613998
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96425990
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96035594
148KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95957463
149HOXB7_26014856_ChIP-Seq_BT474_Human0.95673592
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95655605
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92305188
152HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91472009
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88975159
154POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88311116
155HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86590085
156FOXM1_23109430_ChIP-Seq_U2OS_Human0.85932960
157ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85092339
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84627107
159RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83389871
160CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83195422
161KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79294676
162TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78296772
163PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77161197
164FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76477545
165NOTCH1_21737748_ChIP-Seq_TLL_Human0.75466666
166RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73716146
167LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72670487
168MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.72163704
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71430836
170GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71039078
171SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68591718
172SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67870252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.93381679
2MP0003693_abnormal_embryo_hatching4.23631985
3MP0003186_abnormal_redox_activity3.22498768
4MP0008058_abnormal_DNA_repair3.13709506
5MP0009697_abnormal_copulation3.01653048
6MP0004957_abnormal_blastocyst_morpholog3.00820256
7MP0010094_abnormal_chromosome_stability2.89343177
8MP0008057_abnormal_DNA_replication2.61360624
9MP0000569_abnormal_digit_pigmentation2.59061388
10MP0006292_abnormal_olfactory_placode2.57895651
11MP0003077_abnormal_cell_cycle2.55428104
12MP0005551_abnormal_eye_electrophysiolog2.48270348
13MP0002102_abnormal_ear_morphology2.44364567
14MP0001764_abnormal_homeostasis2.43132053
15MP0003111_abnormal_nucleus_morphology2.43126366
16MP0006072_abnormal_retinal_apoptosis2.33890203
17MP0005646_abnormal_pituitary_gland2.29068033
18MP0006036_abnormal_mitochondrial_physio2.28024309
19MP0009379_abnormal_foot_pigmentation2.18240083
20MP0000372_irregular_coat_pigmentation2.16901427
21MP0002396_abnormal_hematopoietic_system2.14855881
22MP0004885_abnormal_endolymph2.08514797
23MP0003718_maternal_effect2.06815065
24MP0005075_abnormal_melanosome_morpholog2.06705363
25MP0001986_abnormal_taste_sensitivity2.00534040
26MP0008007_abnormal_cellular_replicative1.99382790
27MP0002234_abnormal_pharynx_morphology1.97648077
28MP0002638_abnormal_pupillary_reflex1.96954296
29MP0008932_abnormal_embryonic_tissue1.94317583
30MP0005253_abnormal_eye_physiology1.91095114
31MP0002736_abnormal_nociception_after1.88020929
32MP0008872_abnormal_physiological_respon1.86998310
33MP0003786_premature_aging1.85877569
34MP0003195_calcinosis1.79699506
35MP0001529_abnormal_vocalization1.76194036
36MP0002139_abnormal_hepatobiliary_system1.75327784
37MP0003136_yellow_coat_color1.75221631
38MP0008875_abnormal_xenobiotic_pharmacok1.71296332
39MP0002132_abnormal_respiratory_system1.70991017
40MP0001968_abnormal_touch/_nociception1.69070447
41MP0002160_abnormal_reproductive_system1.66234666
42MP0000490_abnormal_crypts_of1.59186729
43MP0005389_reproductive_system_phenotype1.47481690
44MP0006035_abnormal_mitochondrial_morpho1.45243294
45MP0004147_increased_porphyrin_level1.45000634
46MP0003252_abnormal_bile_duct1.44810903
47MP0008877_abnormal_DNA_methylation1.42248774
48MP0000631_abnormal_neuroendocrine_gland1.40506945
49MP0005408_hypopigmentation1.40282455
50MP0000427_abnormal_hair_cycle1.39023053
51MP0005365_abnormal_bile_salt1.36494770
52MP0003656_abnormal_erythrocyte_physiolo1.36392816
53MP0002837_dystrophic_cardiac_calcinosis1.35001832
54MP0003890_abnormal_embryonic-extraembry1.31726721
55MP0008789_abnormal_olfactory_epithelium1.31381492
56MP0005670_abnormal_white_adipose1.30503007
57MP0002653_abnormal_ependyma_morphology1.30024371
58MP0005360_urolithiasis1.28579125
59MP0000647_abnormal_sebaceous_gland1.27179049
60MP0003123_paternal_imprinting1.26140146
61MP0000313_abnormal_cell_death1.23560403
62MP0009785_altered_susceptibility_to1.20648502
63MP0005645_abnormal_hypothalamus_physiol1.19661172
64MP0001919_abnormal_reproductive_system1.17532311
65MP0003283_abnormal_digestive_organ1.17079240
66MP0001188_hyperpigmentation1.16015185
67MP0003937_abnormal_limbs/digits/tail_de1.13874887
68MP0003315_abnormal_perineum_morphology1.13043754
69MP0009333_abnormal_splenocyte_physiolog1.12101375
70MP0001835_abnormal_antigen_presentation1.09122293
71MP0005084_abnormal_gallbladder_morpholo1.08874623
72MP0003011_delayed_dark_adaptation1.07599092
73MP0008995_early_reproductive_senescence1.06503503
74MP0002148_abnormal_hypersensitivity_rea1.05945948
75MP0005332_abnormal_amino_acid1.05765525
76MP0000566_synostosis1.05536010
77MP0001485_abnormal_pinna_reflex1.05291945
78MP0006054_spinal_hemorrhage1.05230741
79MP0004782_abnormal_surfactant_physiolog1.04728669
80MP0005379_endocrine/exocrine_gland_phen1.04609645
81MP0002210_abnormal_sex_determination1.04491827
82MP0009046_muscle_twitch1.04320623
83MP0001545_abnormal_hematopoietic_system1.03977174
84MP0005397_hematopoietic_system_phenotyp1.03977174
85MP0005195_abnormal_posterior_eye1.03660196
86MP0000013_abnormal_adipose_tissue1.03460643
87MP0004133_heterotaxia1.03280599
88MP0004043_abnormal_pH_regulation1.02786406
89MP0004142_abnormal_muscle_tone1.01077932
90MP0002163_abnormal_gland_morphology1.00986209
91MP0005391_vision/eye_phenotype1.00280624
92MP0006276_abnormal_autonomic_nervous1.00191520
93MP0001853_heart_inflammation0.99804339
94MP0001324_abnormal_eye_pigmentation0.99638177
95MP0005636_abnormal_mineral_homeostasis0.97394779
96MP0001486_abnormal_startle_reflex0.96322611
97MP0002751_abnormal_autonomic_nervous0.95549716
98MP0003763_abnormal_thymus_physiology0.95129617
99MP0001145_abnormal_male_reproductive0.95054506
100MP0005266_abnormal_metabolism0.93969893
101MP0002019_abnormal_tumor_incidence0.93901962
102MP0000689_abnormal_spleen_morphology0.93752878
103MP0000538_abnormal_urinary_bladder0.92660846
104MP0003950_abnormal_plasma_membrane0.92064889
105MP0004381_abnormal_hair_follicle0.91784187
106MP0005085_abnormal_gallbladder_physiolo0.91322993
107MP0005409_darkened_coat_color0.91132852
108MP0005671_abnormal_response_to0.90592897
109MP0002184_abnormal_innervation0.88150607
110MP0002938_white_spotting0.87856175
111MP0002876_abnormal_thyroid_physiology0.87555660
112MP0010329_abnormal_lipoprotein_level0.87031269
113MP0001905_abnormal_dopamine_level0.86550533
114MP0001119_abnormal_female_reproductive0.86505616
115MP0002722_abnormal_immune_system0.86501178
116MP0009745_abnormal_behavioral_response0.86098959
117MP0000653_abnormal_sex_gland0.86065897
118MP0001730_embryonic_growth_arrest0.85493508
119MP0000383_abnormal_hair_follicle0.84611451
120MP0002928_abnormal_bile_duct0.84551604
121MP0002282_abnormal_trachea_morphology0.84314568
122MP0002095_abnormal_skin_pigmentation0.84254655
123MP0003567_abnormal_fetal_cardiomyocyte0.84061033
124MP0000358_abnormal_cell_content/0.83527930
125MP0005376_homeostasis/metabolism_phenot0.83469604
126MP0000026_abnormal_inner_ear0.82400978
127MP0003724_increased_susceptibility_to0.82267039
128MP0001984_abnormal_olfaction0.81305254
129MP0003698_abnormal_male_reproductive0.80948621
130MP0008775_abnormal_heart_ventricle0.80595479
131MP0008260_abnormal_autophagy0.80537741
132MP0002272_abnormal_nervous_system0.79865391
133MP0005025_abnormal_response_to0.79024091
134MP0000371_diluted_coat_color0.78846287
135MP0002009_preneoplasia0.78325899
136MP0000049_abnormal_middle_ear0.78044217
137MP0002398_abnormal_bone_marrow0.77777976
138MP0001542_abnormal_bone_strength0.77325330
139MP0005584_abnormal_enzyme/coenzyme_acti0.77176465
140MP0002429_abnormal_blood_cell0.77095248
141MP0001286_abnormal_eye_development0.76939283
142MP0009643_abnormal_urine_homeostasis0.76236653
143MP0001929_abnormal_gametogenesis0.75307984
144MP0004808_abnormal_hematopoietic_stem0.75251173
145MP0001270_distended_abdomen0.74277095
146MP0004215_abnormal_myocardial_fiber0.73729714
147MP0005410_abnormal_fertilization0.73206955
148MP0005058_abnormal_lysosome_morphology0.73199348
149MP0009384_cardiac_valve_regurgitation0.71593030
150MP0003866_abnormal_defecation0.70911072
151MP0003936_abnormal_reproductive_system0.70803340
152MP0001944_abnormal_pancreas_morphology0.70435208
153MP0001293_anophthalmia0.69501625
154MP0005174_abnormal_tail_pigmentation0.67990737
155MP0005319_abnormal_enzyme/_coenzyme0.66406753
156MP0002420_abnormal_adaptive_immunity0.66197443
157MP0005451_abnormal_body_composition0.64933135
158MP0001819_abnormal_immune_cell0.64499117
159MP0005171_absent_coat_pigmentation0.64215696

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.68828996
2Mitochondrial inheritance (HP:0001427)4.56207964
3Hepatic necrosis (HP:0002605)4.42245116
43-Methylglutaconic aciduria (HP:0003535)4.37747365
5Abnormal mitochondria in muscle tissue (HP:0008316)4.33563245
6Hepatocellular necrosis (HP:0001404)4.30218765
7Decreased activity of mitochondrial respiratory chain (HP:0008972)4.25000786
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.25000786
9Increased CSF lactate (HP:0002490)4.23518313
10Acute encephalopathy (HP:0006846)4.22997346
11True hermaphroditism (HP:0010459)4.07544727
12Pancreatic cysts (HP:0001737)4.01521715
13Increased serum lactate (HP:0002151)3.81706667
14Abnormality of midbrain morphology (HP:0002418)3.76189197
15Molar tooth sign on MRI (HP:0002419)3.76189197
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.72950262
17Progressive macrocephaly (HP:0004481)3.69053466
18Increased hepatocellular lipid droplets (HP:0006565)3.64368180
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.60172883
20Lipid accumulation in hepatocytes (HP:0006561)3.59953477
21Type I transferrin isoform profile (HP:0003642)3.48817873
22Lactic acidosis (HP:0003128)3.39336733
23Reticulocytopenia (HP:0001896)3.34004853
24Renal Fanconi syndrome (HP:0001994)3.30351355
25Cerebral edema (HP:0002181)3.12828836
26Increased intramyocellular lipid droplets (HP:0012240)3.10128140
27Abnormality of the renal cortex (HP:0011035)3.04853009
28Birth length less than 3rd percentile (HP:0003561)3.03981749
29Abnormality of cells of the erythroid lineage (HP:0012130)3.01139270
30Abnormal number of erythroid precursors (HP:0012131)2.99231789
31Aplastic anemia (HP:0001915)2.96661824
32Exercise intolerance (HP:0003546)2.95923429
33Type II lissencephaly (HP:0007260)2.93499124
34Congenital stationary night blindness (HP:0007642)2.90191171
35Nephronophthisis (HP:0000090)2.90067959
36Increased muscle lipid content (HP:0009058)2.88903754
37Respiratory failure (HP:0002878)2.85042306
38Abnormality of glycolysis (HP:0004366)2.80319486
39Increased serum pyruvate (HP:0003542)2.80319486
40Exertional dyspnea (HP:0002875)2.79238765
41Constricted visual fields (HP:0001133)2.78340119
42Cerebral hypomyelination (HP:0006808)2.78121530
43Attenuation of retinal blood vessels (HP:0007843)2.75740968
44Abnormal protein glycosylation (HP:0012346)2.73282101
45Abnormal glycosylation (HP:0012345)2.73282101
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.73282101
47Abnormal protein N-linked glycosylation (HP:0012347)2.73282101
48Abnormality of serum amino acid levels (HP:0003112)2.73026628
49Microvesicular hepatic steatosis (HP:0001414)2.70104697
50Medial flaring of the eyebrow (HP:0010747)2.68423022
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66879657
52Reduced antithrombin III activity (HP:0001976)2.65480679
53Generalized aminoaciduria (HP:0002909)2.62328501
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.61883374
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60795832
56Chronic hepatic failure (HP:0100626)2.59965947
57Hyperglycinemia (HP:0002154)2.52454847
58Methylmalonic acidemia (HP:0002912)2.47667769
59Nausea (HP:0002018)2.46892605
60Pendular nystagmus (HP:0012043)2.44788769
61Type 2 muscle fiber atrophy (HP:0003554)2.44670937
62Abnormality of the renal medulla (HP:0100957)2.42416585
63Abnormal rod and cone electroretinograms (HP:0008323)2.41017750
64Respiratory difficulties (HP:0002880)2.39695531
65Dicarboxylic aciduria (HP:0003215)2.38456435
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38456435
67Sclerocornea (HP:0000647)2.37567054
68CNS demyelination (HP:0007305)2.35060826
69Leukodystrophy (HP:0002415)2.32190399
70Abnormality of the preputium (HP:0100587)2.31225971
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.30994165
72Pancytopenia (HP:0001876)2.30728839
73Macrocytic anemia (HP:0001972)2.27427537
74Lethargy (HP:0001254)2.26819265
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26347908
76Abnormality of alanine metabolism (HP:0010916)2.26347908
77Hyperalaninemia (HP:0003348)2.26347908
78Thrombocytosis (HP:0001894)2.25652252
79Abnormality of the labia minora (HP:0012880)2.24821774
80Optic disc pallor (HP:0000543)2.23365407
81Increased corneal curvature (HP:0100692)2.22998241
82Keratoconus (HP:0000563)2.22998241
83Glycosuria (HP:0003076)2.22962705
84Abnormality of urine glucose concentration (HP:0011016)2.22962705
85Abnormality of fatty-acid metabolism (HP:0004359)2.22400377
86Cystic liver disease (HP:0006706)2.22309180
87Abnormality of the pons (HP:0007361)2.22200382
88Oral leukoplakia (HP:0002745)2.19269389
89Hypoglycemic coma (HP:0001325)2.18377740
90IgM deficiency (HP:0002850)2.17310094
91Hypoproteinemia (HP:0003075)2.17078343
92Muscle fiber atrophy (HP:0100295)2.17043984
93Hypoplasia of the pons (HP:0012110)2.15024633
94Congenital primary aphakia (HP:0007707)2.13082495
95Lissencephaly (HP:0001339)2.12833750
96Abolished electroretinogram (ERG) (HP:0000550)2.12263233
97Cerebellar dysplasia (HP:0007033)2.12238923
98Nephrogenic diabetes insipidus (HP:0009806)2.10404476
99Gait imbalance (HP:0002141)2.09944246
100Hyperglycinuria (HP:0003108)2.09799075
101Abnormality of renal resorption (HP:0011038)2.09382779
102Chromsome breakage (HP:0040012)2.08694132
103Abnormality of pyrimidine metabolism (HP:0004353)2.08165319
104Tubular atrophy (HP:0000092)2.07406379
105Bile duct proliferation (HP:0001408)2.06904338
106Abnormal biliary tract physiology (HP:0012439)2.06904338
107Abnormality of placental membranes (HP:0011409)2.05920620
108Amniotic constriction ring (HP:0009775)2.05920620
109Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04049463
110Abnormality of glycine metabolism (HP:0010895)2.02942858
111Abnormality of serine family amino acid metabolism (HP:0010894)2.02942858
112Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.02798214
113Anencephaly (HP:0002323)2.01279745
114Colon cancer (HP:0003003)2.01181087
115Petechiae (HP:0000967)2.00937832
116Pallor (HP:0000980)1.99811690
117Proximal tubulopathy (HP:0000114)1.99049570
118Renal cortical cysts (HP:0000803)1.98310210
119Microretrognathia (HP:0000308)1.97970074
120CNS hypomyelination (HP:0003429)1.97945066
121Meckel diverticulum (HP:0002245)1.97613860
122Abnormality of homocysteine metabolism (HP:0010919)1.96849768
123Homocystinuria (HP:0002156)1.96849768
124Bone marrow hypocellularity (HP:0005528)1.95141544
125Postaxial foot polydactyly (HP:0001830)1.94865361
126Congenital, generalized hypertrichosis (HP:0004540)1.94556323
127Supernumerary spleens (HP:0009799)1.94272743
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.91870923
129Absent/shortened dynein arms (HP:0200106)1.91870923
130Furrowed tongue (HP:0000221)1.91078376
131Male pseudohermaphroditism (HP:0000037)1.90861346
132Abnormality of the ileum (HP:0001549)1.90037737
133Abnormality of chromosome stability (HP:0003220)1.89925591
134Pancreatic fibrosis (HP:0100732)1.89650108
135Emotional lability (HP:0000712)1.88841610
136Abnormality of DNA repair (HP:0003254)1.86738276
137Chorioretinal atrophy (HP:0000533)1.86107272
138Abnormality of methionine metabolism (HP:0010901)1.85913986
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85326847
140Opisthotonus (HP:0002179)1.85159008
141Volvulus (HP:0002580)1.85094004
142Abnormal respiratory motile cilium morphology (HP:0005938)1.84773930
143Abnormal respiratory epithelium morphology (HP:0012253)1.84773930
144Abnormality of the carotid arteries (HP:0005344)1.82255889
145Hypothermia (HP:0002045)1.82248305
146Vacuolated lymphocytes (HP:0001922)1.82086629
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81788028
148Unsteady gait (HP:0002317)1.80967856
149Breast hypoplasia (HP:0003187)1.80671152
150Dandy-Walker malformation (HP:0001305)1.80150481
151Sloping forehead (HP:0000340)1.79662607
152Dyskinesia (HP:0100660)1.79090916
153Methylmalonic aciduria (HP:0012120)1.78867731
154Rough bone trabeculation (HP:0100670)1.78155860
155Congenital sensorineural hearing impairment (HP:0008527)1.77971145
156Megaloblastic anemia (HP:0001889)1.77480951
157Decreased central vision (HP:0007663)1.76858776
158Genital tract atresia (HP:0001827)1.76776504
159Oligohydramnios (HP:0001562)1.76569139
160Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76410340
161Vaginal atresia (HP:0000148)1.75254084
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.74722674
163Progressive neurologic deterioration (HP:0002344)1.74536311
164Agnosia (HP:0010524)1.74307624
165Hypobetalipoproteinemia (HP:0003563)1.73697784
166Chronic sinusitis (HP:0011109)1.73622089
167Hypomagnesemia (HP:0002917)1.71712512
168Abnormality of sulfur amino acid metabolism (HP:0004339)1.71562315
169Intestinal atresia (HP:0011100)1.71480268
170Myelodysplasia (HP:0002863)1.70945116
171Preaxial hand polydactyly (HP:0001177)1.70084015
172Aplasia/hypoplasia of the uterus (HP:0008684)1.69416436
173Tachypnea (HP:0002789)1.69229181
174Astigmatism (HP:0000483)1.68600550
175Aplasia/Hypoplasia of the uvula (HP:0010293)1.68328484
176Concave nail (HP:0001598)1.68139324
177Hyperphosphaturia (HP:0003109)1.66782941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.56178782
2BUB13.90587478
3EIF2AK13.57373040
4EIF2AK33.30386902
5NUAK13.26413332
6WEE13.15951361
7FRK3.14222133
8BCKDK2.96031031
9WNK32.87783412
10NME22.81365496
11MAP4K22.51205582
12SRPK12.44035795
13BMPR1B2.37478508
14PBK2.34125579
15INSRR2.27407759
16VRK22.25216908
17NME12.18470676
18VRK12.06491072
19ZAK1.99706533
20TLK11.93160588
21IRAK31.89658597
22WNK41.85773148
23ACVR1B1.74872105
24STK391.63742482
25TSSK61.62799314
26PIM21.59556947
27MUSK1.58995541
28PLK41.56791910
29MAPK131.48561668
30EPHA21.47712860
31TESK21.41591284
32MAP3K41.39723275
33PASK1.38355628
34CCNB11.38248502
35CDC71.35104292
36TAF11.34990351
37CDK81.32416082
38PNCK1.30583388
39BRSK21.25825491
40DYRK31.25697360
41EIF2AK21.17112417
42PINK11.16605494
43PLK11.16524758
44PLK21.15047890
45KDR1.14969819
46MKNK11.14357646
47MAPKAPK51.12743332
48CAMKK21.12479805
49BRAF1.09649364
50TTK1.08568539
51TRIM281.08190286
52ADRBK21.07870174
53CDK71.06497762
54ARAF1.01999457
55SIK31.01118188
56MAP3K121.00820255
57TEC1.00465681
58PRKCE0.99758513
59TAOK30.96897879
60CSNK1G10.96178191
61CSNK1G20.94331883
62ERBB30.94154449
63CDK190.90961419
64AKT30.89796707
65CDK30.88112541
66MYLK0.87862758
67NEK10.87563075
68CSNK1G30.87062311
69FLT30.86589627
70IRAK10.86532439
71AURKA0.86185460
72ATR0.85147629
73OXSR10.84810859
74MKNK20.84627716
75IRAK40.83545412
76AURKB0.83543909
77BRSK10.81264877
78CSNK2A10.79551109
79LIMK10.78919435
80MAP2K60.78803657
81TNK20.78284849
82PAK30.76712119
83MST40.76698863
84TGFBR10.76447436
85IKBKE0.76246602
86KIT0.75922858
87STK40.75886966
88RPS6KA50.75764144
89STK30.73694623
90ADRBK10.72582959
91DYRK20.72326063
92ABL20.71426796
93BCR0.69757735
94TXK0.69632228
95PLK30.69522994
96PIK3CA0.69509564
97MAP4K10.68197898
98PRKCG0.65432499
99NEK90.64891658
100MAPK150.64072575
101STK240.63820433
102CLK10.63507223
103CSNK1A1L0.62795282
104RPS6KB20.62709022
105NTRK20.62461298
106BTK0.62305970
107YES10.61769031
108CDK90.61604158
109TNIK0.59720964
110IKBKB0.59104523
111PIM10.58516324
112CSNK2A20.57863903
113CHEK20.57791079
114DAPK10.57498334
115BMPR20.56264630
116NEK60.56243488
117MAP3K110.55319093
118NEK20.53879457
119RPS6KA40.53608392
120MAPKAPK30.53194538
121LATS10.52144291
122LYN0.50634518
123ATM0.49907500
124CSNK1A10.47980531
125TESK10.46940373
126PIK3CG0.43605039
127IGF1R0.40137644
128RPS6KA60.38237126
129RPS6KL10.37961875
130RPS6KC10.37961875
131CASK0.37953956
132PRPF4B0.37702697
133STK38L0.36588888
134GRK10.36005155
135CAMK2G0.34672618
136PAK10.34439197
137RPS6KB10.32674979
138PRKCQ0.32586263
139CSNK1D0.31926064
140EPHB20.31132860
141PRKCI0.30568840
142PHKG10.30281807
143PHKG20.30281807
144MAP2K70.29945915
145EPHA30.29541375
146MET0.29032159
147PAK40.28770088

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.98486354
2Ribosome_Homo sapiens_hsa030103.63696422
3DNA replication_Homo sapiens_hsa030303.55599019
4Mismatch repair_Homo sapiens_hsa034303.24479870
5Protein export_Homo sapiens_hsa030602.98740873
6RNA polymerase_Homo sapiens_hsa030202.91841016
7Oxidative phosphorylation_Homo sapiens_hsa001902.83973412
8Parkinsons disease_Homo sapiens_hsa050122.57251916
9Nucleotide excision repair_Homo sapiens_hsa034202.39929101
10Homologous recombination_Homo sapiens_hsa034402.35026356
11Pyrimidine metabolism_Homo sapiens_hsa002402.30635416
12Base excision repair_Homo sapiens_hsa034102.23462322
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18315813
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11874665
15Folate biosynthesis_Homo sapiens_hsa007902.02056669
16One carbon pool by folate_Homo sapiens_hsa006701.93918334
17Huntingtons disease_Homo sapiens_hsa050161.92664065
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92446475
19Spliceosome_Homo sapiens_hsa030401.91912763
20Nitrogen metabolism_Homo sapiens_hsa009101.80747903
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69798719
22Alzheimers disease_Homo sapiens_hsa050101.68830375
23Non-homologous end-joining_Homo sapiens_hsa034501.63018243
24Sulfur metabolism_Homo sapiens_hsa009201.61679814
25Basal transcription factors_Homo sapiens_hsa030221.61292971
26Phototransduction_Homo sapiens_hsa047441.60801904
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58798992
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57884907
29Caffeine metabolism_Homo sapiens_hsa002321.55890226
30Fatty acid elongation_Homo sapiens_hsa000621.50752100
31RNA transport_Homo sapiens_hsa030131.49042373
32RNA degradation_Homo sapiens_hsa030181.44497427
33Fanconi anemia pathway_Homo sapiens_hsa034601.43567298
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41018758
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36183689
36Purine metabolism_Homo sapiens_hsa002301.31872777
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29129520
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26539204
39Ether lipid metabolism_Homo sapiens_hsa005651.20469659
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20148281
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.18957257
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17177611
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13533617
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12882667
45Sulfur relay system_Homo sapiens_hsa041221.12680881
46Fatty acid biosynthesis_Homo sapiens_hsa000611.12540014
47Cell cycle_Homo sapiens_hsa041101.11561813
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10578965
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05609084
50Glutathione metabolism_Homo sapiens_hsa004801.01506508
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99851273
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.95866551
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94734292
54Pentose phosphate pathway_Homo sapiens_hsa000300.94536028
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94012751
56Nicotine addiction_Homo sapiens_hsa050330.93741391
57Vitamin B6 metabolism_Homo sapiens_hsa007500.92834530
58Metabolic pathways_Homo sapiens_hsa011000.91059727
59Selenocompound metabolism_Homo sapiens_hsa004500.90741401
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88429202
61Peroxisome_Homo sapiens_hsa041460.86861268
62Fructose and mannose metabolism_Homo sapiens_hsa000510.84627701
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81892473
64Pyruvate metabolism_Homo sapiens_hsa006200.81650931
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81169800
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80419693
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79363031
68Carbon metabolism_Homo sapiens_hsa012000.78405891
69Propanoate metabolism_Homo sapiens_hsa006400.77512083
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.77491157
71Galactose metabolism_Homo sapiens_hsa000520.77323618
72Steroid biosynthesis_Homo sapiens_hsa001000.73954077
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73337921
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72871421
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72720506
76Biosynthesis of amino acids_Homo sapiens_hsa012300.71774949
77Other glycan degradation_Homo sapiens_hsa005110.71676622
78Olfactory transduction_Homo sapiens_hsa047400.71294785
79Taste transduction_Homo sapiens_hsa047420.71165685
80Arachidonic acid metabolism_Homo sapiens_hsa005900.70878796
81Chemical carcinogenesis_Homo sapiens_hsa052040.69398582
82N-Glycan biosynthesis_Homo sapiens_hsa005100.64895627
83Fat digestion and absorption_Homo sapiens_hsa049750.63653476
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63442772
85Histidine metabolism_Homo sapiens_hsa003400.62626508
86Systemic lupus erythematosus_Homo sapiens_hsa053220.62468826
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62302679
88Fatty acid degradation_Homo sapiens_hsa000710.61003308
89Morphine addiction_Homo sapiens_hsa050320.59526519
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59381190
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.58361078
92GABAergic synapse_Homo sapiens_hsa047270.57223460
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56667637
94Regulation of autophagy_Homo sapiens_hsa041400.56097953
95p53 signaling pathway_Homo sapiens_hsa041150.54682405
96Retinol metabolism_Homo sapiens_hsa008300.54212108
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.50805620
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48780227
99Epstein-Barr virus infection_Homo sapiens_hsa051690.48177717
100beta-Alanine metabolism_Homo sapiens_hsa004100.46863097
101Glycerolipid metabolism_Homo sapiens_hsa005610.45545839
102Collecting duct acid secretion_Homo sapiens_hsa049660.45373171
103Serotonergic synapse_Homo sapiens_hsa047260.44695629
104Sphingolipid metabolism_Homo sapiens_hsa006000.43604175
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.43473530
106Tyrosine metabolism_Homo sapiens_hsa003500.42732352
107Arginine and proline metabolism_Homo sapiens_hsa003300.42051709
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41627127
109ABC transporters_Homo sapiens_hsa020100.39931611
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38829706
111Cardiac muscle contraction_Homo sapiens_hsa042600.38313644
112Antigen processing and presentation_Homo sapiens_hsa046120.38143006
113mRNA surveillance pathway_Homo sapiens_hsa030150.35377193
114Legionellosis_Homo sapiens_hsa051340.31243669
115Phenylalanine metabolism_Homo sapiens_hsa003600.28996588
116Butanoate metabolism_Homo sapiens_hsa006500.28749377
117Fatty acid metabolism_Homo sapiens_hsa012120.28326399
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28146017
119Linoleic acid metabolism_Homo sapiens_hsa005910.27717064
120Vitamin digestion and absorption_Homo sapiens_hsa049770.27616263
121Herpes simplex infection_Homo sapiens_hsa051680.27109587
122Tryptophan metabolism_Homo sapiens_hsa003800.26639670
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22946013
124Primary immunodeficiency_Homo sapiens_hsa053400.22670453
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22591795

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