DTHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a death domain. Death domain-containing proteins function in signaling pathways and formation of signaling complexes, as well as the apoptosis pathway. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)8.39911272
2regulation of cilium movement (GO:0003352)8.11092924
3axoneme assembly (GO:0035082)7.76828333
4ventricular system development (GO:0021591)7.71175669
5epithelial cilium movement (GO:0003351)6.66978926
6motile cilium assembly (GO:0044458)6.34441449
7primary alcohol catabolic process (GO:0034310)6.29661074
8progesterone metabolic process (GO:0042448)6.04906991
9GTP biosynthetic process (GO:0006183)5.93354229
10left/right axis specification (GO:0070986)5.88906782
11vitamin transmembrane transport (GO:0035461)5.65372279
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.64724036
13ethanol metabolic process (GO:0006067)5.27895292
14tolerance induction (GO:0002507)5.25600494
15UTP biosynthetic process (GO:0006228)5.23445552
16regulation of activation of Janus kinase activity (GO:0010533)5.19000558
17nucleoside diphosphate phosphorylation (GO:0006165)5.18985604
18response to xenobiotic stimulus (GO:0009410)5.10096214
19C21-steroid hormone biosynthetic process (GO:0006700)4.92589297
20UTP metabolic process (GO:0046051)4.80936856
21regulation of interleukin-5 production (GO:0032674)4.74088036
22negative regulation of B cell mediated immunity (GO:0002713)4.66299707
23negative regulation of immunoglobulin mediated immune response (GO:0002890)4.66299707
24regulation of microtubule-based movement (GO:0060632)4.61574159
25positive regulation of tolerance induction (GO:0002645)4.61242646
26positive regulation of protein kinase C signaling (GO:0090037)4.56586031
27microtubule bundle formation (GO:0001578)4.45508077
28pyrimidine-containing compound transmembrane transport (GO:0072531)4.43909818
29negative regulation of humoral immune response (GO:0002921)4.41809625
30microtubule severing (GO:0051013)4.33276554
31regulation of macrophage chemotaxis (GO:0010758)4.29645997
32regulation of memory T cell differentiation (GO:0043380)4.27152472
33centriole assembly (GO:0098534)4.19975035
34regulation of pigment cell differentiation (GO:0050932)4.12655598
35regulation of interleukin-13 production (GO:0032656)4.12377794
36negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.12183586
37embryonic retina morphogenesis in camera-type eye (GO:0060059)4.10900762
38intraciliary transport (GO:0042073)4.07343577
39regulation of germinal center formation (GO:0002634)4.06769644
40lateral ventricle development (GO:0021670)4.03776414
41lung epithelium development (GO:0060428)3.99452290
42energy homeostasis (GO:0097009)3.92029478
43negative regulation of inclusion body assembly (GO:0090084)3.91248860
44ethanol oxidation (GO:0006069)3.91014232
45negative regulation of T cell differentiation in thymus (GO:0033085)3.82872397
46retinal rod cell development (GO:0046548)3.82467868
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.80767481
48cilium organization (GO:0044782)3.79124037
49axon ensheathment in central nervous system (GO:0032291)3.75515107
50central nervous system myelination (GO:0022010)3.75515107
51C21-steroid hormone metabolic process (GO:0008207)3.75181748
52positive regulation of interleukin-12 production (GO:0032735)3.71503170
53signal complex assembly (GO:0007172)3.68591384
54regulation of tolerance induction (GO:0002643)3.67049986
55CTP biosynthetic process (GO:0006241)3.63258756
56CTP metabolic process (GO:0046036)3.63258756
57T-helper 1 type immune response (GO:0042088)3.62696185
58regulation of mononuclear cell migration (GO:0071675)3.59920526
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.58887145
60retinoic acid metabolic process (GO:0042573)3.54567571
61cytoplasmic microtubule organization (GO:0031122)3.53525825
62cilium assembly (GO:0042384)3.52503659
63cilium morphogenesis (GO:0060271)3.51545400
64sperm capacitation (GO:0048240)3.49733547
65establishment of apical/basal cell polarity (GO:0035089)3.49301889
66terpenoid biosynthetic process (GO:0016114)3.48358796
67NIK/NF-kappaB signaling (GO:0038061)3.44598832
68regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.43804737
69regulation of dendritic cell antigen processing and presentation (GO:0002604)3.40379162
70guanosine-containing compound biosynthetic process (GO:1901070)3.39391644
71pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.27332091
72ADP metabolic process (GO:0046031)3.22232141
73regulation of granulocyte chemotaxis (GO:0071622)3.13002636
74cellular component assembly involved in morphogenesis (GO:0010927)3.09961378
75hydrogen peroxide biosynthetic process (GO:0050665)3.08409690
76pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.07707661
77microtubule depolymerization (GO:0007019)3.06886156
78determination of left/right symmetry (GO:0007368)3.05352251
79regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.05283312
80O-glycan processing (GO:0016266)3.03886880
81positive thymic T cell selection (GO:0045059)3.00421466
82regulation of RIG-I signaling pathway (GO:0039535)2.97112046
83exogenous drug catabolic process (GO:0042738)2.96919089
84retinal cone cell development (GO:0046549)2.96124343
85microtubule-based movement (GO:0007018)2.93037993
86establishment or maintenance of monopolar cell polarity (GO:0061339)2.92678085
87establishment of monopolar cell polarity (GO:0061162)2.92678085
88determination of bilateral symmetry (GO:0009855)2.92348550
89positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.92197703
90microtubule polymerization or depolymerization (GO:0031109)2.91314211
91establishment of tissue polarity (GO:0007164)2.88948483
92establishment of planar polarity (GO:0001736)2.88948483
93nonribosomal peptide biosynthetic process (GO:0019184)2.88494050
94specification of symmetry (GO:0009799)2.85239549
95neutrophil activation involved in immune response (GO:0002283)2.83486687
96positive regulation of smoothened signaling pathway (GO:0045880)2.82213783
97negative regulation of adaptive immune response (GO:0002820)2.82045772
98response to muramyl dipeptide (GO:0032495)2.80411635
99nucleoside diphosphate metabolic process (GO:0009132)2.79216371
100diterpenoid biosynthetic process (GO:0016102)2.77243626
101low-density lipoprotein particle clearance (GO:0034383)2.76315341
102photoreceptor cell differentiation (GO:0046530)2.75922663
103eye photoreceptor cell differentiation (GO:0001754)2.75922663
104lateral sprouting from an epithelium (GO:0060601)2.75811428
105glomerular epithelial cell development (GO:0072310)2.73943372
106positive regulation of T-helper cell differentiation (GO:0045624)2.73743450
107positive regulation of striated muscle cell differentiation (GO:0051155)2.72961881
108positive regulation of developmental pigmentation (GO:0048087)2.72285428
109reactive oxygen species biosynthetic process (GO:1903409)2.71995170
110hypotonic response (GO:0006971)2.71511743
111nucleotide phosphorylation (GO:0046939)2.71110526
112regulation of T-helper 2 cell differentiation (GO:0045628)2.70727892
113granulocyte activation (GO:0036230)2.69534291
114iron ion import (GO:0097286)2.67163978
115cell projection assembly (GO:0030031)2.65635989
116microtubule-based process (GO:0007017)2.65251050
117primary alcohol metabolic process (GO:0034308)2.64582100
118pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.63349832
119myeloid dendritic cell activation (GO:0001773)2.62159831
120retinol metabolic process (GO:0042572)2.62029383
121myeloid dendritic cell differentiation (GO:0043011)2.61676015
122positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.61580999
123positive regulation of meiosis (GO:0045836)2.61252296
124neutrophil activation (GO:0042119)2.60153826
125establishment of nucleus localization (GO:0040023)2.57618500
126positive regulation of interleukin-17 production (GO:0032740)2.52248057
127phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.51879219
128photoreceptor cell maintenance (GO:0045494)2.50498686
129developmental induction (GO:0031128)2.46413979
130protein localization to cilium (GO:0061512)2.45974167
131purinergic nucleotide receptor signaling pathway (GO:0035590)2.44958323
132negative regulation of lymphocyte mediated immunity (GO:0002707)2.42925646
133regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.42833697
134regulation of interleukin-6 biosynthetic process (GO:0045408)2.42259203
135apical protein localization (GO:0045176)2.40713091
136negative regulation of skeletal muscle tissue development (GO:0048642)2.40604677
137regulation of neutrophil chemotaxis (GO:0090022)2.40195655
138regulation of neutrophil migration (GO:1902622)2.40195655
139positive regulation of humoral immune response (GO:0002922)2.39162817
140positive regulation of neutrophil migration (GO:1902624)2.39054330
141positive regulation of neutrophil chemotaxis (GO:0090023)2.39054330
142activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.39046622
143glutathione derivative metabolic process (GO:1901685)2.38981566
144glutathione derivative biosynthetic process (GO:1901687)2.38981566
145organelle assembly (GO:0070925)2.38825451
146multicellular organismal water homeostasis (GO:0050891)2.37775894
147phosphatidylcholine biosynthetic process (GO:0006656)2.37188817
148negative regulation of T-helper cell differentiation (GO:0045623)2.36968604
149negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.36968604
150cell-cell signaling involved in cell fate commitment (GO:0045168)2.36532011
151drug catabolic process (GO:0042737)2.36500989
152sperm motility (GO:0030317)2.36292997
153intra-S DNA damage checkpoint (GO:0031573)2.35156252
154one-carbon compound transport (GO:0019755)2.35115888
155regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.35032730
156positive regulation of meiotic cell cycle (GO:0051446)2.34329260
157regulation of hypersensitivity (GO:0002883)2.34019910
158positive regulation of defense response to virus by host (GO:0002230)2.33655317
159antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.33018319
160smoothened signaling pathway (GO:0007224)2.32592201
161glomerular visceral epithelial cell development (GO:0072015)2.31919380
162heart looping (GO:0001947)2.30447618
163regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.29948164
164regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.29678219
165positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.29594165
166regulation of microtubule depolymerization (GO:0031114)2.28730292
167gas transport (GO:0015669)2.28301371
168regulation of mesenchymal cell apoptotic process (GO:2001053)2.27605826
169regulation of interleukin-4 production (GO:0032673)2.27315287
170cellular response to nicotine (GO:0071316)2.27287347
171negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.25178520
172protein O-linked glycosylation (GO:0006493)2.22794236
173regulation of inclusion body assembly (GO:0090083)2.21755754
174cilium movement (GO:0003341)10.9840557
175axonemal dynein complex assembly (GO:0070286)10.6913180
176cilium or flagellum-dependent cell motility (GO:0001539)10.3911660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.29666125
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20762056
3AR_21572438_ChIP-Seq_LNCaP_Human2.77280195
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63063316
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54466786
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.46744572
7IGF1R_20145208_ChIP-Seq_DFB_Human2.45653093
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.38595925
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.34636853
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13467317
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12247186
12PCGF2_27294783_Chip-Seq_NPCs_Mouse1.93744498
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90885068
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85724865
15EZH2_27294783_Chip-Seq_ESCs_Mouse1.79910604
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.79806193
17FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.69279001
18VDR_22108803_ChIP-Seq_LS180_Human1.66425706
19SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66311494
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.62192030
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.61404111
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60705999
23EZH2_27294783_Chip-Seq_NPCs_Mouse1.60142572
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.59266936
25* TP63_23658742_ChIP-Seq_EP156T_Human1.58938643
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.57580847
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57479823
28AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57455479
29CTNNB1_20460455_ChIP-Seq_HCT116_Human1.54150702
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52427037
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.52228444
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52120853
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.52031311
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.51254391
35RUNX_20019798_ChIP-Seq_JUKART_Human1.51213432
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.50860907
37TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49690830
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49067414
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48534867
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48072862
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47063588
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46054399
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45534788
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43489841
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43049604
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43049604
47DROSHA_22980978_ChIP-Seq_HELA_Human1.42466269
48ER_23166858_ChIP-Seq_MCF-7_Human1.41366569
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40950254
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40312527
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.39868986
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39564797
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.37865688
54SMAD4_21799915_ChIP-Seq_A2780_Human1.37436903
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37233608
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37125774
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36993417
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36305237
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36207047
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36167012
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36046043
62GATA1_19941826_ChIP-Seq_K562_Human1.35890868
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.34152293
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.33307143
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.32872921
66STAT1_20625510_ChIP-Seq_HELA_Human1.32794923
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30388833
68SMC4_20622854_ChIP-Seq_HELA_Human1.29715254
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.29256791
70KLF5_25053715_ChIP-Seq_YYC3_Human1.28989323
71TP53_16413492_ChIP-PET_HCT116_Human1.28453589
72LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26316974
73P300_19829295_ChIP-Seq_ESCs_Human1.25822856
74ETV1_20927104_ChIP-Seq_GIST48_Human1.25294825
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25266993
76VDR_24787735_ChIP-Seq_THP-1_Human1.25019842
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24693018
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.24646636
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24526083
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22787267
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20340664
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19974151
83LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18819137
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18611172
85RNF2_27304074_Chip-Seq_NSC_Mouse1.17898172
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17734470
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.17209968
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.16921954
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16876150
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16663159
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15830969
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15543166
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.15414425
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.14760580
95SMRT_27268052_Chip-Seq_Bcells_Human1.14144268
96P53_22387025_ChIP-Seq_ESCs_Mouse1.13246307
97SOX2_20726797_ChIP-Seq_SW620_Human1.12801990
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12712015
99TP53_18474530_ChIP-ChIP_U2OS_Human1.12174991
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11330831
101SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10336405
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10256985
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.09964872
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09792732
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.09714791
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09270592
107AHR_22903824_ChIP-Seq_MCF-7_Human1.09209601
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08708394
109HNFA_21074721_ChIP-Seq_CACO-2_Human1.08650164
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08458151
111GATA2_19941826_ChIP-Seq_K562_Human1.06848689
112TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06822123
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06564077
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06387667
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06210381
116CDX2_20551321_ChIP-Seq_CACO-2_Human1.05828527
117CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05827244
118PHF8_20622853_ChIP-Seq_HELA_Human1.05361468
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04866819
120* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04624831
121* TP63_22573176_ChIP-Seq_HFKS_Human1.04175604
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03579953
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.03246798
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01677342
125GATA4_25053715_ChIP-Seq_YYC3_Human1.01497408
126WDR5_24793694_ChIP-Seq_LNCAP_Human1.01362179
127IRF8_27001747_Chip-Seq_BMDM_Mouse1.00853431
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00725420
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00318211
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.00146879
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98525689
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.98272845
133TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98097509
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.98008732
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.97706037
136RBPJ_21746931_ChIP-Seq_IB4_Human0.97442564
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97384580
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97248149
139GATA3_27048872_Chip-Seq_THYMUS_Human0.96768206
140CEBPB_22108803_ChIP-Seq_LS180_Human0.96669139
141NFYA_21822215_ChIP-Seq_K562_Human0.96419501
142TBL1_22424771_ChIP-Seq_293T_Human0.96391579
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96378044
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96254780
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96088900
146P300_18555785_Chip-Seq_ESCs_Mouse0.95541907
147STAT3_23295773_ChIP-Seq_U87_Human0.95217076
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.94805723
149ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94703614
150CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94568936
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94544139
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.94395707
153TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94325787
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.94115747
155CJUN_26792858_Chip-Seq_BT549_Human0.93568395
156BCAT_22108803_ChIP-Seq_LS180_Human0.91884169
157NFYB_21822215_ChIP-Seq_K562_Human0.90060091
158TCF4_22108803_ChIP-Seq_LS180_Human0.89409349
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.89144573
160* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88947977
161GATA6_21074721_ChIP-Seq_CACO-2_Human0.87908972
162CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87675566
163RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86938545
164FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86730247
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85971080
166GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85801174
167GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83458365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.78141969
2MP0008875_abnormal_xenobiotic_pharmacok6.25414370
3MP0002132_abnormal_respiratory_system5.65020536
4MP0008004_abnormal_stomach_pH4.53365991
5MP0001984_abnormal_olfaction3.62804522
6MP0003950_abnormal_plasma_membrane3.53089451
7MP0002928_abnormal_bile_duct3.41879027
8MP0005623_abnormal_meninges_morphology3.39109386
9MP0004043_abnormal_pH_regulation3.36958991
10MP0004381_abnormal_hair_follicle3.19962037
11MP0010234_abnormal_vibrissa_follicle3.00278393
12MP0000383_abnormal_hair_follicle2.69681000
13MP0003303_peritoneal_inflammation2.66537813
14MP0004133_heterotaxia2.61727012
15MP0001348_abnormal_lacrimal_gland2.60447547
16MP0009785_altered_susceptibility_to2.42795252
17MP0001853_heart_inflammation2.40896138
18MP0005647_abnormal_sex_gland2.37478443
19MP0010678_abnormal_skin_adnexa2.17820001
20MP0003656_abnormal_erythrocyte_physiolo2.17409758
21MP0001502_abnormal_circadian_rhythm2.04036930
22MP0005377_hearing/vestibular/ear_phenot1.95514863
23MP0003878_abnormal_ear_physiology1.95514863
24MP0005387_immune_system_phenotype1.93699311
25MP0001790_abnormal_immune_system1.93699311
26MP0008789_abnormal_olfactory_epithelium1.89103846
27MP0001835_abnormal_antigen_presentation1.84277426
28MP0000685_abnormal_immune_system1.83639885
29MP0001765_abnormal_ion_homeostasis1.79989427
30MP0000569_abnormal_digit_pigmentation1.79015101
31MP0003724_increased_susceptibility_to1.77262842
32MP0004510_myositis1.75779732
33MP0003191_abnormal_cellular_cholesterol1.70279333
34MP0000613_abnormal_salivary_gland1.65813629
35MP0006082_CNS_inflammation1.64596562
36MP0001346_abnormal_lacrimal_gland1.64221382
37MP0005083_abnormal_biliary_tract1.59389554
38MP0000470_abnormal_stomach_morphology1.59228406
39MP0001873_stomach_inflammation1.58141821
40MP0004019_abnormal_vitamin_homeostasis1.55137488
41MP0002653_abnormal_ependyma_morphology1.53932470
42MP0001986_abnormal_taste_sensitivity1.52957768
43MP0002160_abnormal_reproductive_system1.52378608
44MP0002148_abnormal_hypersensitivity_rea1.51914858
45MP0002102_abnormal_ear_morphology1.51903941
46MP0003763_abnormal_thymus_physiology1.50725583
47MP0005174_abnormal_tail_pigmentation1.48304572
48MP0003436_decreased_susceptibility_to1.46019467
49MP0000465_gastrointestinal_hemorrhage1.43912660
50MP0000566_synostosis1.41192432
51MP0002138_abnormal_hepatobiliary_system1.39179319
52MP0005000_abnormal_immune_tolerance1.38376020
53MP0004883_abnormal_blood_vessel1.34571919
54MP0008057_abnormal_DNA_replication1.33868656
55MP0002638_abnormal_pupillary_reflex1.32465807
56MP0005310_abnormal_salivary_gland1.31215596
57MP0005164_abnormal_response_to1.27474432
58MP0004270_analgesia1.26162055
59MP0006292_abnormal_olfactory_placode1.24532575
60MP0003880_abnormal_central_pattern1.24522150
61MP0002909_abnormal_adrenal_gland1.22910235
62MP0005671_abnormal_response_to1.21813057
63MP0005379_endocrine/exocrine_gland_phen1.19081001
64MP0003866_abnormal_defecation1.16321720
65MP0005025_abnormal_response_to1.16096733
66MP0001851_eye_inflammation1.12072081
67MP0000920_abnormal_myelination1.10338321
68MP0003091_abnormal_cell_migration1.05080495
69MP0003252_abnormal_bile_duct1.02685731
70MP0002452_abnormal_antigen_presenting1.02265935
71MP0003690_abnormal_glial_cell1.00524489
72MP0009046_muscle_twitch0.99443204
73MP0005165_increased_susceptibility_to0.99075628
74MP0002723_abnormal_immune_serum0.98885532
75MP0005636_abnormal_mineral_homeostasis0.98456080
76MP0000678_abnormal_parathyroid_gland0.97858476
77MP0001800_abnormal_humoral_immune0.97517916
78MP0005395_other_phenotype0.96847197
79MP0005394_taste/olfaction_phenotype0.95729213
80MP0005499_abnormal_olfactory_system0.95729213
81MP0002282_abnormal_trachea_morphology0.95370371
82MP0009780_abnormal_chondrocyte_physiolo0.92984662
83MP0005248_abnormal_Harderian_gland0.92605358
84MP0003937_abnormal_limbs/digits/tail_de0.91295308
85MP0000049_abnormal_middle_ear0.91196670
86MP0009840_abnormal_foam_cell0.88809581
87MP0005381_digestive/alimentary_phenotyp0.88384271
88MP0002136_abnormal_kidney_physiology0.87510425
89MP0005075_abnormal_melanosome_morpholog0.87079007
90MP0002133_abnormal_respiratory_system0.86719742
91MP0005388_respiratory_system_phenotype0.86719742
92MP0003183_abnormal_peptide_metabolism0.86655831
93MP0003634_abnormal_glial_cell0.86563251
94MP0001663_abnormal_digestive_system0.85346852
95MP0002876_abnormal_thyroid_physiology0.84708585
96MP0000778_abnormal_nervous_system0.83567387
97MP0009765_abnormal_xenobiotic_induced0.83526367
98MP0009763_increased_sensitivity_to0.82133826
99MP0000858_altered_metastatic_potential0.81251816
100MP0003943_abnormal_hepatobiliary_system0.79863972
101MP0002254_reproductive_system_inflammat0.79833965
102MP0002405_respiratory_system_inflammati0.79813863
103MP0009643_abnormal_urine_homeostasis0.79728544
104MP0002419_abnormal_innate_immunity0.79626958
105MP0003453_abnormal_keratinocyte_physiol0.79608228
106MP0002295_abnormal_pulmonary_circulatio0.77259290
107MP0003938_abnormal_ear_development0.76775280
108MP0000538_abnormal_urinary_bladder0.76704938
109MP0009745_abnormal_behavioral_response0.76394041
110MP0002277_abnormal_respiratory_mucosa0.76153794
111MP0004264_abnormal_extraembryonic_tissu0.75400276
112MP0000015_abnormal_ear_pigmentation0.75024757
113MP0000428_abnormal_craniofacial_morphol0.74658172
114MP0002064_seizures0.74567692
115MP0009764_decreased_sensitivity_to0.74255248
116MP0003045_fibrosis0.74122126
117MP0005389_reproductive_system_phenotype0.73749157
118MP0010155_abnormal_intestine_physiology0.72871564
119MP0002249_abnormal_larynx_morphology0.72014020
120MP0002163_abnormal_gland_morphology0.71890101
121MP0004859_abnormal_synaptic_plasticity0.71353663
122MP0005076_abnormal_cell_differentiation0.71235978
123MP0001819_abnormal_immune_cell0.69677654
124MP0004947_skin_inflammation0.67858662
125MP0000377_abnormal_hair_follicle0.67794329
126MP0002938_white_spotting0.66781696
127MP0001501_abnormal_sleep_pattern0.66684351
128MP0002420_abnormal_adaptive_immunity0.65975509
129MP0002168_other_aberrant_phenotype0.65593326
130MP0008775_abnormal_heart_ventricle0.65504024
131MP0002332_abnormal_exercise_endurance0.64554234
132MP0004742_abnormal_vestibular_system0.64458710
133MP0001533_abnormal_skeleton_physiology0.64433788
134MP0005409_darkened_coat_color0.64136591
135MP0003942_abnormal_urinary_system0.63101112
136MP0001845_abnormal_inflammatory_respons0.62218856
137MP0005220_abnormal_exocrine_pancreas0.61732912
138MP0000681_abnormal_thyroid_gland0.61544982
139MP0001485_abnormal_pinna_reflex0.61353805
140MP0005408_hypopigmentation0.60000173
141MP0008874_decreased_physiological_sensi0.59254348
142MP0001727_abnormal_embryo_implantation0.59220226
143MP0003075_altered_response_to0.58761251
144MP0000767_abnormal_smooth_muscle0.58361996
145MP0001968_abnormal_touch/_nociception0.57171793
146MP0005464_abnormal_platelet_physiology0.56816408
147MP0008961_abnormal_basal_metabolism0.56109724
148MP0002734_abnormal_mechanical_nocicepti0.54306924
149MP0000249_abnormal_blood_vessel0.53938702
150MP0003828_pulmonary_edema0.52961098
151MP0001664_abnormal_digestion0.52799233
152MP0002098_abnormal_vibrissa_morphology0.52781100
153MP0002233_abnormal_nose_morphology0.52107376
154MP0008873_increased_physiological_sensi0.51650110
155MP0002735_abnormal_chemical_nociception0.50830381
156MP0002135_abnormal_kidney_morphology0.50310972
157MP0005253_abnormal_eye_physiology0.50168241

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.65339736
2Rhinitis (HP:0012384)8.14078923
3Abnormal respiratory epithelium morphology (HP:0012253)7.50144410
4Abnormal respiratory motile cilium morphology (HP:0005938)7.50144410
5Nasal polyposis (HP:0100582)7.30360668
6Absent/shortened dynein arms (HP:0200106)6.28024663
7Dynein arm defect of respiratory motile cilia (HP:0012255)6.28024663
8Abnormality of the nasal mucosa (HP:0000433)5.98543186
9Bronchiectasis (HP:0002110)5.46665872
10Chronic bronchitis (HP:0004469)4.91069877
11Male infertility (HP:0003251)4.29651755
12Back pain (HP:0003418)4.12214876
13True hermaphroditism (HP:0010459)4.07490637
14Chronic sinusitis (HP:0011109)4.03360005
15Occipital encephalocele (HP:0002085)4.02727770
16Abnormal umbilical cord blood vessels (HP:0011403)3.88915880
17Single umbilical artery (HP:0001195)3.88915880
18Abnormality of the fetal cardiovascular system (HP:0010948)3.88915880
19Pancreatic fibrosis (HP:0100732)3.64467985
20Bronchitis (HP:0012387)3.43359531
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.27730821
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.27730821
23Infertility (HP:0000789)3.10376337
24Chronic hepatic failure (HP:0100626)2.87834330
25Recurrent sinusitis (HP:0011108)2.80334344
26Bile duct proliferation (HP:0001408)2.80267461
27Abnormal biliary tract physiology (HP:0012439)2.80267461
28Hyperactive renin-angiotensin system (HP:0000841)2.75067407
29Male pseudohermaphroditism (HP:0000037)2.71443195
30Abnormality of midbrain morphology (HP:0002418)2.71116093
31Molar tooth sign on MRI (HP:0002419)2.71116093
32Supernumerary spleens (HP:0009799)2.70120001
33Neoplasm of head and neck (HP:0012288)2.65686090
34Esophageal neoplasm (HP:0100751)2.65686090
35Nephronophthisis (HP:0000090)2.64462067
36Asplenia (HP:0001746)2.62784742
37Atelectasis (HP:0100750)2.61056038
38Abnormality of dentin (HP:0010299)2.48079745
39Termporal pattern (HP:0011008)2.47451965
40Insidious onset (HP:0003587)2.47451965
41Abnormality of the corticospinal tract (HP:0002492)2.47264052
42Recurrent bronchitis (HP:0002837)2.44885967
43Postaxial foot polydactyly (HP:0001830)2.36318841
44Gastrointestinal infarctions (HP:0005244)2.34863888
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.34843709
46Sex reversal (HP:0012245)2.30787171
47Abnormal sex determination (HP:0012244)2.30787171
48Tubulointerstitial nephritis (HP:0001970)2.28668164
49Anencephaly (HP:0002323)2.19609178
50Pancreatic cysts (HP:0001737)2.18839127
51Gait imbalance (HP:0002141)2.18543102
52Abnormality of the renal medulla (HP:0100957)2.15981927
53Abnormality of the umbilical cord (HP:0010881)2.15012047
54Congenital primary aphakia (HP:0007707)2.14433129
55Cystic liver disease (HP:0006706)2.14068728
56Medial flaring of the eyebrow (HP:0010747)2.13743816
57Median cleft lip (HP:0000161)2.13218115
58Petechiae (HP:0000967)2.08554997
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07880359
60Fibular hypoplasia (HP:0003038)2.06092247
61Congenital hepatic fibrosis (HP:0002612)2.00565321
62Abnormal ciliary motility (HP:0012262)10.9611447
63Abnormal respiratory motile cilium physiology (HP:0012261)10.6984982
64Hydroxyprolinuria (HP:0003080)1.99320640
65Abnormality of proline metabolism (HP:0010907)1.99320640
66Recurrent otitis media (HP:0000403)1.96861317
67Concave nail (HP:0001598)1.96355158
68Nephrogenic diabetes insipidus (HP:0009806)1.95459432
69Adrenal hypoplasia (HP:0000835)1.95229379
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.95117954
71Myokymia (HP:0002411)1.95089936
72Chronic obstructive pulmonary disease (HP:0006510)1.94269064
73Obstructive lung disease (HP:0006536)1.94269064
74Bell-shaped thorax (HP:0001591)1.91447782
75Absent frontal sinuses (HP:0002688)1.90724783
76Natal tooth (HP:0000695)1.90359181
77Abnormality of molar (HP:0011077)1.86480901
78Abnormality of molar morphology (HP:0011070)1.86480901
79J-shaped sella turcica (HP:0002680)1.84556442
80Abnormality of permanent molar morphology (HP:0011071)1.83210823
81Abnormality of the dental root (HP:0006486)1.83210823
82Taurodontia (HP:0000679)1.83210823
83Disinhibition (HP:0000734)1.78897088
84Furrowed tongue (HP:0000221)1.76945940
85Retrobulbar optic neuritis (HP:0100654)1.76668182
86Optic neuritis (HP:0100653)1.76668182
87Abnormality of the fingertips (HP:0001211)1.74250140
88Decreased circulating renin level (HP:0003351)1.74130157
89Tubular atrophy (HP:0000092)1.73975556
90Long nose (HP:0003189)1.70761381
91Broad distal phalanx of finger (HP:0009836)1.70090685
92Genetic anticipation (HP:0003743)1.70069714
93Hypotelorism (HP:0000601)1.68781821
94Breech presentation (HP:0001623)1.68685392
95Genital tract atresia (HP:0001827)1.67803671
96Joint hemorrhage (HP:0005261)1.66736864
97Oculomotor apraxia (HP:0000657)1.65379762
98Abnormality of the dental pulp (HP:0006479)1.65262103
99Hypochromic anemia (HP:0001931)1.65232514
100Hyperkalemia (HP:0002153)1.62648036
101Nephropathy (HP:0000112)1.62106740
102Pulmonary artery stenosis (HP:0004415)1.61960008
103Neonatal short-limb short stature (HP:0008921)1.61921140
104Renal salt wasting (HP:0000127)1.60475469
105Oral leukoplakia (HP:0002745)1.59624249
106Increased IgE level (HP:0003212)1.57886395
107Poor coordination (HP:0002370)1.57384098
108Hemiplegia (HP:0002301)1.54798471
109Autoimmune hemolytic anemia (HP:0001890)1.54632941
110Vaginal atresia (HP:0000148)1.52804180
111Recurrent gram-negative bacterial infections (HP:0005420)1.51782712
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50343711
113Chronic otitis media (HP:0000389)1.50313212
114Asymmetry of the thorax (HP:0001555)1.48039942
115Cone-rod dystrophy (HP:0000548)1.47660593
116Postaxial hand polydactyly (HP:0001162)1.43687871
117Right ventricular cardiomyopathy (HP:0011663)1.43123075
118Preaxial hand polydactyly (HP:0001177)1.43027586
119Hip dysplasia (HP:0001385)1.42970679
120Sclerocornea (HP:0000647)1.41484255
121Glucose intolerance (HP:0000833)1.36286529
122Tubulointerstitial abnormality (HP:0001969)1.35533355
123Hyperaldosteronism (HP:0000859)1.34882417
124Abnormality of chloride homeostasis (HP:0011422)1.32867964
125Abnormal rod and cone electroretinograms (HP:0008323)1.31053702
126Hypokalemic alkalosis (HP:0001949)1.26775819
127Abnormality of renin-angiotensin system (HP:0000847)1.21182342
128Abnormality of the frontal sinuses (HP:0002687)1.19920303
129Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.18390459
130Short thorax (HP:0010306)1.17270849
131Decreased central vision (HP:0007663)1.09851923
132Stage 5 chronic kidney disease (HP:0003774)1.09616253
133Hyponatremia (HP:0002902)1.08424056
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.06412127
135Abnormality of the renal cortex (HP:0011035)1.06308764
136Tubulointerstitial fibrosis (HP:0005576)1.00908512
137Bifid scrotum (HP:0000048)1.00639727
138Hand muscle atrophy (HP:0009130)0.99659028
139Abnormal drinking behavior (HP:0030082)0.99658486
140Polydipsia (HP:0001959)0.99658486
141Lip pit (HP:0100267)0.95166076
142Abnormality of the distal phalanges of the toes (HP:0010182)0.93863060
143Recurrent pneumonia (HP:0006532)0.93773478
144Elevated erythrocyte sedimentation rate (HP:0003565)0.93746049
145Obstructive sleep apnea (HP:0002870)0.93621392
146Short nail (HP:0001799)0.91550925
147Portal hypertension (HP:0001409)0.91015386
148Fetal akinesia sequence (HP:0001989)0.90971245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.27648669
2MAP3K143.53306333
3EPHA23.50976658
4BMPR23.18323364
5MST43.08010229
6GRK13.06843835
7PNCK2.69491942
8EPHB12.65307777
9MAP3K22.23088472
10IKBKB2.10029341
11IKBKE1.94024030
12IRAK11.92501478
13RIPK41.91446202
14MAP3K101.90692726
15CASK1.82026494
16CDC42BPA1.71197869
17CHUK1.69961939
18MAP3K31.69900192
19RPS6KA21.67095951
20FRK1.66291139
21STK241.62821118
22TBK11.50149233
23MAP3K71.44022619
24IRAK31.40059003
25BCR1.37941765
26NME11.37624896
27MUSK1.37201651
28PIM21.35832800
29SMG11.32641123
30MARK21.32267392
31ERBB31.30549251
32EPHA31.29079037
33LRRK21.26414552
34HIPK21.24866058
35PAK21.24770829
36GSK3A1.22789148
37CLK11.21217056
38PKN11.15201002
39PTK2B1.15053910
40MAP2K71.13410885
41SIK31.13288375
42PTK61.07630413
43RPS6KA61.07223189
44TRPM71.04536175
45ITK1.03194031
46STK31.02821000
47RPS6KA51.01954255
48RPS6KL10.99990049
49RPS6KC10.99990049
50PRKCE0.98340897
51CAMKK10.97422588
52ERBB20.96703218
53TYK20.94906617
54TEC0.92607377
55NTRK20.90838886
56TTK0.90623280
57GRK60.89799030
58ZAP700.88201881
59FER0.85711685
60CSK0.83628270
61BLK0.83140829
62STK380.81547526
63FGFR20.80661604
64PAK60.78384147
65EEF2K0.78297411
66SIK10.75863563
67BMX0.75078731
68CAMKK20.73245048
69ROCK20.71953036
70RPS6KA10.71326474
71FES0.70248377
72ICK0.69931697
73BTK0.69011193
74TAOK10.68123069
75FGFR30.67932167
76TNK20.67572051
77MAPKAPK30.67308627
78JAK10.67261306
79TLK10.65371298
80NEK60.65258795
81MST1R0.63763581
82PINK10.63054235
83DMPK0.62997906
84MAP2K40.62930011
85RPS6KB10.61891596
86EPHA40.61458759
87ROCK10.61127202
88EIF2AK20.60903776
89STK390.60776469
90YES10.60335493
91TRIB30.60203222
92NTRK30.59879939
93TNIK0.58920781
94STK110.58108605
95PRKCQ0.57373108
96CAMK2D0.56506787
97PRKG20.54417036
98BRSK20.53546497
99PRKACG0.53389942
100PRKG10.53069804
101DYRK1B0.51680485
102VRK10.51606956
103PRKCI0.51414396
104MAP4K10.49534678
105SGK10.49256463
106CAMK2A0.48986179
107CAMK1G0.46801972
108SIK20.46508688
109CAMK2G0.45214935
110PDPK10.45044197
111SGK20.44429332
112MAP2K20.44368300
113PRKCD0.43957180
114PDK10.43949731
115CDK60.43593639
116TSSK60.43414650
117FYN0.42185790
118PAK30.41720105
119PRKAA20.40925184
120PIM10.40490812
121PRKCG0.40283704
122IRAK40.40163200
123NEK90.40147794
124NLK0.39878451
125ABL20.39373336
126OXSR10.39006130
127STK100.38816275
128CDK50.38457790
129UHMK10.37669442
130RET0.37513656
131TXK0.36993426
132FGFR40.36377204
133HCK0.35917000
134PRKACA0.35463859
135CAMK2B0.35035413
136DYRK20.34767012
137ABL10.34391967
138LYN0.34391400
139PRKCH0.33085442
140LCK0.32095584
141ADRBK10.31330477
142CDK120.31099098
143MAP2K60.29679235
144SGK30.28625593
145JAK30.28168712
146JAK20.27625442
147EGFR0.26140880
148RIPK10.25951982
149MAP3K130.25553254
150MAP3K120.25357919
151MAP3K40.24360414
152ACVR1B0.23669051
153MELK0.23603683
154DYRK1A0.23486256
155IRAK20.22999850
156SGK4940.22994876
157SGK2230.22994876
158CDK30.21863727
159RPS6KB20.21286730
160MAP2K30.21203268

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.63589948
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.99911896
3Chemical carcinogenesis_Homo sapiens_hsa052043.78489374
4Tyrosine metabolism_Homo sapiens_hsa003502.77987858
5Histidine metabolism_Homo sapiens_hsa003402.46786191
6Ovarian steroidogenesis_Homo sapiens_hsa049132.33690360
7beta-Alanine metabolism_Homo sapiens_hsa004102.30606329
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13170290
9Pertussis_Homo sapiens_hsa051332.09373094
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91373892
11Caffeine metabolism_Homo sapiens_hsa002321.90900236
12Allograft rejection_Homo sapiens_hsa053301.89335843
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85406015
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81466499
15ABC transporters_Homo sapiens_hsa020101.80855270
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78657036
17Linoleic acid metabolism_Homo sapiens_hsa005911.77800719
18Glutathione metabolism_Homo sapiens_hsa004801.66788773
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.66570592
20Prolactin signaling pathway_Homo sapiens_hsa049171.64067350
21Rheumatoid arthritis_Homo sapiens_hsa053231.63119117
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45040366
23Retinol metabolism_Homo sapiens_hsa008301.43404290
24Leishmaniasis_Homo sapiens_hsa051401.43106783
25Osteoclast differentiation_Homo sapiens_hsa043801.40069819
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36159014
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34979445
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34677068
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.34390242
30Staphylococcus aureus infection_Homo sapiens_hsa051501.33067703
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.30215339
32T cell receptor signaling pathway_Homo sapiens_hsa046601.29465627
33Butanoate metabolism_Homo sapiens_hsa006501.28290416
34Circadian rhythm_Homo sapiens_hsa047101.27688073
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26775276
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24988280
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23287644
38Arginine and proline metabolism_Homo sapiens_hsa003301.22815579
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21237360
40Graft-versus-host disease_Homo sapiens_hsa053321.20889963
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.16379438
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15763835
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.13038333
44TNF signaling pathway_Homo sapiens_hsa046681.12785796
45Tight junction_Homo sapiens_hsa045301.10877254
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10163332
47Tryptophan metabolism_Homo sapiens_hsa003801.09684087
48Hepatitis C_Homo sapiens_hsa051601.03984376
49Malaria_Homo sapiens_hsa051441.03672788
50Choline metabolism in cancer_Homo sapiens_hsa052311.02362552
51Toxoplasmosis_Homo sapiens_hsa051451.01802602
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00497407
53Autoimmune thyroid disease_Homo sapiens_hsa053200.98117587
54Type I diabetes mellitus_Homo sapiens_hsa049400.97382999
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96977610
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.96719662
57GnRH signaling pathway_Homo sapiens_hsa049120.96401407
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93060475
59B cell receptor signaling pathway_Homo sapiens_hsa046620.92355495
60Glutamatergic synapse_Homo sapiens_hsa047240.92233060
61Notch signaling pathway_Homo sapiens_hsa043300.91740957
62Arachidonic acid metabolism_Homo sapiens_hsa005900.90156633
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88661991
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.87910659
65Axon guidance_Homo sapiens_hsa043600.87553961
66Measles_Homo sapiens_hsa051620.87370147
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85847606
68Huntingtons disease_Homo sapiens_hsa050160.84502282
69Viral myocarditis_Homo sapiens_hsa054160.84431757
70Circadian entrainment_Homo sapiens_hsa047130.83705931
71Phototransduction_Homo sapiens_hsa047440.83512478
72Chemokine signaling pathway_Homo sapiens_hsa040620.83025620
73Vitamin B6 metabolism_Homo sapiens_hsa007500.81771404
74Legionellosis_Homo sapiens_hsa051340.81267652
75Complement and coagulation cascades_Homo sapiens_hsa046100.80833221
76Starch and sucrose metabolism_Homo sapiens_hsa005000.80463157
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79783744
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78968695
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78753279
80GABAergic synapse_Homo sapiens_hsa047270.78534580
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.76592297
82African trypanosomiasis_Homo sapiens_hsa051430.73990232
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73309683
84Renin secretion_Homo sapiens_hsa049240.73261034
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72575722
86Primary immunodeficiency_Homo sapiens_hsa053400.71685793
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70269730
88Adherens junction_Homo sapiens_hsa045200.70078557
89Fatty acid degradation_Homo sapiens_hsa000710.68486111
90ErbB signaling pathway_Homo sapiens_hsa040120.68012015
91Hematopoietic cell lineage_Homo sapiens_hsa046400.67782135
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66422858
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65597057
94Cholinergic synapse_Homo sapiens_hsa047250.64018187
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62292007
96Peroxisome_Homo sapiens_hsa041460.62008848
97Serotonergic synapse_Homo sapiens_hsa047260.61642165
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61627180
99Apoptosis_Homo sapiens_hsa042100.61571158
100Influenza A_Homo sapiens_hsa051640.60865698
101Salivary secretion_Homo sapiens_hsa049700.60367415
102Calcium signaling pathway_Homo sapiens_hsa040200.60160665
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.60033324
104Asthma_Homo sapiens_hsa053100.59663736
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59210265
106Dilated cardiomyopathy_Homo sapiens_hsa054140.58789709
107Taste transduction_Homo sapiens_hsa047420.57454448
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57281240
109Morphine addiction_Homo sapiens_hsa050320.57190076
110Fatty acid elongation_Homo sapiens_hsa000620.57124466
111cAMP signaling pathway_Homo sapiens_hsa040240.54970713
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.54740034
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.54666423
114Ether lipid metabolism_Homo sapiens_hsa005650.54515808
115Type II diabetes mellitus_Homo sapiens_hsa049300.54363731
116Phenylalanine metabolism_Homo sapiens_hsa003600.52912892
117Dorso-ventral axis formation_Homo sapiens_hsa043200.52325298
118Antigen processing and presentation_Homo sapiens_hsa046120.51910153
119Prion diseases_Homo sapiens_hsa050200.50497276
120Gastric acid secretion_Homo sapiens_hsa049710.50247189
121Collecting duct acid secretion_Homo sapiens_hsa049660.50165978
122Tuberculosis_Homo sapiens_hsa051520.50061380
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49919250
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.49873817
125Long-term depression_Homo sapiens_hsa047300.48092864
126Sphingolipid metabolism_Homo sapiens_hsa006000.47222812
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.47181243
128Olfactory transduction_Homo sapiens_hsa047400.46964800
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46104577
130Oxytocin signaling pathway_Homo sapiens_hsa049210.44719232
131Ras signaling pathway_Homo sapiens_hsa040140.44176113
132Amoebiasis_Homo sapiens_hsa051460.43475644
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43284196
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42547192
135Insulin secretion_Homo sapiens_hsa049110.42351550
136Pancreatic cancer_Homo sapiens_hsa052120.38005489
137Insulin resistance_Homo sapiens_hsa049310.34357070
138Phagosome_Homo sapiens_hsa041450.33170515
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31864400
140Prostate cancer_Homo sapiens_hsa052150.31681968
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27815878
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.26640046
143Non-small cell lung cancer_Homo sapiens_hsa052230.26306899
144Endocytosis_Homo sapiens_hsa041440.23997338
145PPAR signaling pathway_Homo sapiens_hsa033200.22445443
146Endometrial cancer_Homo sapiens_hsa052130.20952058
147Acute myeloid leukemia_Homo sapiens_hsa052210.20769897

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