DTNB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.19610357
2synaptic vesicle exocytosis (GO:0016079)6.14565311
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.28606645
4glutamate secretion (GO:0014047)5.28177546
5regulation of synaptic vesicle exocytosis (GO:2000300)5.19685094
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.02244050
7establishment of mitochondrion localization (GO:0051654)4.77080267
8positive regulation of amino acid transport (GO:0051957)4.52905300
9neurotransmitter secretion (GO:0007269)4.48432494
10regulation of synaptic vesicle transport (GO:1902803)4.36489153
11regulation of glutamate secretion (GO:0014048)4.29863958
12neuron cell-cell adhesion (GO:0007158)4.10430169
13postsynaptic membrane organization (GO:0001941)4.10289315
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.10250857
15aggressive behavior (GO:0002118)4.08969481
16gamma-aminobutyric acid transport (GO:0015812)4.08969129
17neurotransmitter-gated ion channel clustering (GO:0072578)4.04991173
18positive regulation of membrane potential (GO:0045838)3.97643311
19behavioral fear response (GO:0001662)3.86216080
20behavioral defense response (GO:0002209)3.86216080
21regulation of transmission of nerve impulse (GO:0051969)3.79129796
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.76345638
23regulation of vesicle fusion (GO:0031338)3.73878518
24protein kinase C signaling (GO:0070528)3.72912673
25female mating behavior (GO:0060180)3.70967987
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.70596964
27presynaptic membrane assembly (GO:0097105)3.69096168
28glutamate receptor signaling pathway (GO:0007215)3.67472800
29microtubule nucleation (GO:0007020)3.64364200
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.63832172
31positive regulation of vesicle fusion (GO:0031340)3.63722230
32G-protein coupled receptor internalization (GO:0002031)3.61052067
33vocalization behavior (GO:0071625)3.56746943
34exploration behavior (GO:0035640)3.56383963
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55529370
36synaptic vesicle endocytosis (GO:0048488)3.53727635
37fear response (GO:0042596)3.49989199
38regulation of female receptivity (GO:0045924)3.48361142
39transmission of nerve impulse (GO:0019226)3.46874988
40L-serine metabolic process (GO:0006563)3.46374528
41positive regulation of synapse maturation (GO:0090129)3.43446152
42establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.41271421
43mitochondrion transport along microtubule (GO:0047497)3.41271421
44righting reflex (GO:0060013)3.40557623
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.39328395
46synaptic transmission, glutamatergic (GO:0035249)3.38542401
47regulation of glutamate receptor signaling pathway (GO:1900449)3.38495689
48cell migration in hindbrain (GO:0021535)3.35900997
49urinary tract smooth muscle contraction (GO:0014848)3.30638380
50regulation of neurotransmitter levels (GO:0001505)3.30253401
51phosphatidylglycerol biosynthetic process (GO:0006655)3.26833076
52pyrimidine nucleobase catabolic process (GO:0006208)3.26675268
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.26443720
54ATP hydrolysis coupled proton transport (GO:0015991)3.26443720
55presynaptic membrane organization (GO:0097090)3.25065304
56neurotransmitter transport (GO:0006836)3.24369845
57behavioral response to nicotine (GO:0035095)3.23894193
58regulation of NFAT protein import into nucleus (GO:0051532)3.23119359
59positive regulation of neurotransmitter transport (GO:0051590)3.22742786
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22641339
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22641339
62positive regulation of neurotransmitter secretion (GO:0001956)3.22510789
63regulation of neuronal synaptic plasticity (GO:0048168)3.20300716
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.19798696
65protein localization to synapse (GO:0035418)3.19715143
66locomotory exploration behavior (GO:0035641)3.19639565
67startle response (GO:0001964)3.19541801
68regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19241045
69cilium or flagellum-dependent cell motility (GO:0001539)3.17146152
70synaptic vesicle transport (GO:0048489)3.14919687
71establishment of synaptic vesicle localization (GO:0097480)3.14919687
72dendritic spine organization (GO:0097061)3.12504041
73sodium-independent organic anion transport (GO:0043252)3.10478855
74regulation of neurotransmitter secretion (GO:0046928)3.09601093
75central nervous system projection neuron axonogenesis (GO:0021952)3.08387293
76cilium movement (GO:0003341)3.07217090
77neuron-neuron synaptic transmission (GO:0007270)3.06113973
78microtubule depolymerization (GO:0007019)3.05043032
79female gonad development (GO:0008585)2.99210814
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98819183
81neuronal action potential propagation (GO:0019227)2.98724076
82limb bud formation (GO:0060174)2.97561454
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95984016
84protein localization to cilium (GO:0061512)2.94619404
85regulation of voltage-gated calcium channel activity (GO:1901385)2.94511132
86dendritic spine morphogenesis (GO:0060997)2.94052606
87epithelial cilium movement (GO:0003351)2.93259888
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.92545755
89neuron recognition (GO:0008038)2.92053040
90synapse assembly (GO:0007416)2.90608519
91maternal behavior (GO:0042711)2.89073616
92positive regulation of organic acid transport (GO:0032892)2.88031798
93keratinocyte development (GO:0003334)2.87998464
94sulfur amino acid catabolic process (GO:0000098)2.86434403
95cochlea development (GO:0090102)2.86364192
96regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85170900
97histone H4-K12 acetylation (GO:0043983)2.83961532
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.83776861
99regulation of amino acid transport (GO:0051955)2.82542517
100primary amino compound metabolic process (GO:1901160)2.81916322
101regulation of synapse maturation (GO:0090128)2.81769235
102regulation of timing of cell differentiation (GO:0048505)2.80710211
103regulation of synapse structural plasticity (GO:0051823)2.80328225
104amino acid import (GO:0043090)2.80177720
105positive regulation of meiosis (GO:0045836)2.79898927
106regulation of dendritic spine morphogenesis (GO:0061001)2.78706079
107positive regulation of mitochondrial fission (GO:0090141)2.78602425
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78037617
109axonal fasciculation (GO:0007413)2.77933216
110negative regulation of granulocyte differentiation (GO:0030853)2.77126236
111regulation of synaptic plasticity (GO:0048167)2.76734008
112white fat cell differentiation (GO:0050872)2.76392447
113intraspecies interaction between organisms (GO:0051703)2.76272093
114social behavior (GO:0035176)2.76272093
115retina layer formation (GO:0010842)2.76180307
116preassembly of GPI anchor in ER membrane (GO:0016254)2.76153239
117DNA methylation involved in gamete generation (GO:0043046)2.75148295
118neuronal action potential (GO:0019228)2.74643367
119L-amino acid import (GO:0043092)2.74043784
120cerebellar Purkinje cell differentiation (GO:0021702)2.73396596
121regulation of postsynaptic membrane potential (GO:0060078)2.72707164
122adult walking behavior (GO:0007628)2.72337004
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72085301
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.70454486
125DNA strand renaturation (GO:0000733)2.70409932
126positive regulation of meiotic cell cycle (GO:0051446)2.69736603
127neurofilament cytoskeleton organization (GO:0060052)2.69460335
128innervation (GO:0060384)2.69328500
129central nervous system neuron axonogenesis (GO:0021955)2.68660346
130negative regulation of microtubule polymerization (GO:0031115)2.68076554
131transferrin transport (GO:0033572)2.67639640
132neuromuscular synaptic transmission (GO:0007274)2.67017380
133inner ear receptor cell development (GO:0060119)2.66472211
134cerebellar granule cell differentiation (GO:0021707)2.66161269
135auditory behavior (GO:0031223)2.66071188
136regulation of protein targeting to membrane (GO:0090313)2.66063756
137homocysteine metabolic process (GO:0050667)2.65842007
138regulation of neurotransmitter transport (GO:0051588)2.65840304
139neuromuscular process controlling balance (GO:0050885)2.65548109
140positive regulation of synapse assembly (GO:0051965)2.65113651
141behavioral response to cocaine (GO:0048148)2.64223658
142mesenchymal cell differentiation involved in renal system development (GO:2001012)2.64080149
143mesenchymal cell differentiation involved in kidney development (GO:0072161)2.64080149
144regulation of synaptic transmission, glutamatergic (GO:0051966)2.63093681
145motile cilium assembly (GO:0044458)2.62351690
146long-term memory (GO:0007616)2.62048598
147regulation of development, heterochronic (GO:0040034)2.60965368
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60846990
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.60846990
150regulation of translation, ncRNA-mediated (GO:0045974)2.60846990
151long-chain fatty acid biosynthetic process (GO:0042759)2.59543540
152centriole assembly (GO:0098534)2.59446656
153calcium ion import (GO:0070509)2.58883193
154cranial nerve morphogenesis (GO:0021602)2.58590242
155hyperosmotic salinity response (GO:0042538)2.58309099
156reflex (GO:0060004)2.57215172
157inner ear receptor stereocilium organization (GO:0060122)2.54353687
158acrosome reaction (GO:0007340)2.54054992
159cAMP-mediated signaling (GO:0019933)2.53633600
160regulation of synapse assembly (GO:0051963)2.52912155
161histone H3-K4 trimethylation (GO:0080182)2.51851415
162short-term memory (GO:0007614)2.51164991
163termination of G-protein coupled receptor signaling pathway (GO:0038032)2.50747044
164serotonin receptor signaling pathway (GO:0007210)2.50594266
165developmental pigmentation (GO:0048066)2.50018765
166cilium assembly (GO:0042384)2.49135970
167neuronal ion channel clustering (GO:0045161)2.48588170
168cranial nerve structural organization (GO:0021604)2.47965129
169cerebral cortex radially oriented cell migration (GO:0021799)2.47444181
170negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.46600190
171parental behavior (GO:0060746)2.44344225
172axonemal dynein complex assembly (GO:0070286)2.43129293
173forebrain neuron differentiation (GO:0021879)2.42907331
174positive regulation of CREB transcription factor activity (GO:0032793)2.41345680
175glucocorticoid biosynthetic process (GO:0006704)2.41260585
176regulation of respiratory gaseous exchange (GO:0043576)2.40940194
177opioid receptor signaling pathway (GO:0038003)2.40890206
178positive regulation of dendritic spine development (GO:0060999)2.40455984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.79899476
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.46638360
3EZH2_22144423_ChIP-Seq_EOC_Human5.06106474
4GBX2_23144817_ChIP-Seq_PC3_Human4.26054838
5* REST_18959480_ChIP-ChIP_MESCs_Mouse3.12143123
6* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62501260
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52285402
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46752401
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.45884798
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.43427182
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.38050192
12TAF15_26573619_Chip-Seq_HEK293_Human2.30669927
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.29723162
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27323526
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23619527
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19313495
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19281669
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.18530906
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16603265
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.16179886
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11759997
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.11703495
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08192398
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.07049722
25SUZ12_27294783_Chip-Seq_NPCs_Mouse2.01582964
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01147593
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99991216
28RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.99084017
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97046770
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95044778
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.93418375
32SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.89374635
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88466260
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.88137509
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86781731
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86704581
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.81167954
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79612834
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79196966
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79196966
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.78909474
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.78667987
43* P300_19829295_ChIP-Seq_ESCs_Human1.78582652
44RNF2_27304074_Chip-Seq_NSC_Mouse1.76855737
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.75030719
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.74959796
47DROSHA_22980978_ChIP-Seq_HELA_Human1.72298495
48VDR_22108803_ChIP-Seq_LS180_Human1.71284502
49REST_21632747_ChIP-Seq_MESCs_Mouse1.70344084
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69270694
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68715770
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68254210
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67703810
54IGF1R_20145208_ChIP-Seq_DFB_Human1.67698748
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67539428
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.67284756
57CIITA_25753668_ChIP-Seq_RAJI_Human1.66884101
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64392294
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.63815409
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.63406510
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.63032101
62P53_22387025_ChIP-Seq_ESCs_Mouse1.61819144
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58455700
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.58117178
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56858046
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56509223
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56509223
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.56103830
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54894363
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54650176
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.54251454
72AR_21572438_ChIP-Seq_LNCaP_Human1.52681416
73P68_20966046_ChIP-Seq_HELA_Human1.52142165
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51816362
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51197689
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.50996582
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.50566108
78P300_18555785_Chip-Seq_ESCs_Mouse1.50482108
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.50430182
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49650725
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48283983
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48067571
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47927046
84FUS_26573619_Chip-Seq_HEK293_Human1.45428604
85SMC4_20622854_ChIP-Seq_HELA_Human1.45148906
86RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43540999
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.41686710
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.41045683
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.38930952
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.38892040
91CTCF_27219007_Chip-Seq_Bcells_Human1.38615135
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.37473886
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.35341273
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34703428
95ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33562692
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33264604
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32793216
98IRF1_19129219_ChIP-ChIP_H3396_Human1.32316619
99KLF4_18555785_Chip-Seq_ESCs_Mouse1.32035451
100OCT4_19829295_ChIP-Seq_ESCs_Human1.31605720
101* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30915466
102KDM5A_27292631_Chip-Seq_BREAST_Human1.30268921
103PU1_27457419_Chip-Seq_LIVER_Mouse1.30213744
104ZFX_18555785_Chip-Seq_ESCs_Mouse1.30173706
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29236694
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28675918
107* TCF4_23295773_ChIP-Seq_U87_Human1.28400432
108* STAT3_23295773_ChIP-Seq_U87_Human1.27594575
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27231979
110GABP_19822575_ChIP-Seq_HepG2_Human1.26290711
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25910547
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25494983
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24333346
114RUNX2_22187159_ChIP-Seq_PCA_Human1.23842428
115ER_23166858_ChIP-Seq_MCF-7_Human1.23782682
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23549934
117CTCF_18555785_Chip-Seq_ESCs_Mouse1.22558086
118SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21238644
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19686380
120EWS_26573619_Chip-Seq_HEK293_Human1.19469762
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19400701
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19194088
123CREB1_26743006_Chip-Seq_LNCaP_Human1.17057014
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.16920865
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.16235206
126LXR_22292898_ChIP-Seq_THP-1_Human1.14968070
127* KDM2B_26808549_Chip-Seq_REH_Human1.14607014
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13188816
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12745170
130IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11786551
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.11631643
132* KDM2B_26808549_Chip-Seq_K562_Human1.11308397
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10860058
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10635532
135HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10608835
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09705252
137HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08413656
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08124805
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07993666
140* AR_25329375_ChIP-Seq_VCAP_Human1.07361323
141TP63_19390658_ChIP-ChIP_HaCaT_Human1.07177774
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04639855
143TP53_18474530_ChIP-ChIP_U2OS_Human1.04018507
144E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02911003
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02219687
146SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01235906
147* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00609413
148* TET1_21451524_ChIP-Seq_MESCs_Mouse1.00567298
149PHF8_20622854_ChIP-Seq_HELA_Human1.00545762
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97140387
151JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96099679
152E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95810745
153ZNF274_21170338_ChIP-Seq_K562_Hela0.95251674
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93223141
155CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92911546
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91871465
157KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91305275
158SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87648923
159ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86944847
160SA1_27219007_Chip-Seq_Bcells_Human0.85294851
161OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84627938
162SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84582194
163TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84533362
164* AR_19668381_ChIP-Seq_PC3_Human0.84346841
165OCT4_20526341_ChIP-Seq_ESCs_Human0.83676604
166BCOR_27268052_Chip-Seq_Bcells_Human0.82657608
167CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82546167
168* TP63_22573176_ChIP-Seq_HFKS_Human0.82222493
169E2F1_20622854_ChIP-Seq_HELA_Human0.82204713
170* MITF_21258399_ChIP-Seq_MELANOMA_Human0.81233399
171BCL6_27268052_Chip-Seq_Bcells_Human0.80112323
172SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79436577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.67509875
2MP0005645_abnormal_hypothalamus_physiol3.49205736
3MP0001188_hyperpigmentation3.28489347
4MP0006292_abnormal_olfactory_placode3.14664225
5MP0003136_yellow_coat_color3.00357777
6MP0005409_darkened_coat_color2.86613721
7MP0005423_abnormal_somatic_nervous2.82477689
8MP0004859_abnormal_synaptic_plasticity2.72832528
9MP0000566_synostosis2.70953262
10MP0001986_abnormal_taste_sensitivity2.48174469
11MP0002102_abnormal_ear_morphology2.36635147
12MP0000569_abnormal_digit_pigmentation2.27947320
13MP0001486_abnormal_startle_reflex2.24302062
14MP0004381_abnormal_hair_follicle2.23703182
15MP0002735_abnormal_chemical_nociception2.08650676
16MP0009745_abnormal_behavioral_response2.07693044
17MP0009379_abnormal_foot_pigmentation2.07351830
18MP0003635_abnormal_synaptic_transmissio2.04679629
19MP0002572_abnormal_emotion/affect_behav1.88198942
20MP0003183_abnormal_peptide_metabolism1.88183999
21MP0001968_abnormal_touch/_nociception1.84478791
22MP0000015_abnormal_ear_pigmentation1.79608196
23MP0002277_abnormal_respiratory_mucosa1.76627290
24MP0005174_abnormal_tail_pigmentation1.75868811
25MP0005646_abnormal_pituitary_gland1.71964121
26MP0002063_abnormal_learning/memory/cond1.68799324
27MP0004811_abnormal_neuron_physiology1.68593713
28MP0004270_analgesia1.65103780
29MP0003787_abnormal_imprinting1.64228669
30MP0000778_abnormal_nervous_system1.63321911
31MP0002822_catalepsy1.61557059
32MP0008569_lethality_at_weaning1.59998769
33MP0004742_abnormal_vestibular_system1.59596464
34MP0002272_abnormal_nervous_system1.58655726
35MP0008995_early_reproductive_senescence1.55273249
36MP0005171_absent_coat_pigmentation1.54536010
37MP0005551_abnormal_eye_electrophysiolog1.54319104
38MP0002734_abnormal_mechanical_nocicepti1.54090868
39MP0002653_abnormal_ependyma_morphology1.53929428
40MP0009046_muscle_twitch1.53854035
41MP0002064_seizures1.52171399
42MP0006276_abnormal_autonomic_nervous1.51488563
43MP0008877_abnormal_DNA_methylation1.49043827
44MP0002557_abnormal_social/conspecific_i1.48912356
45MP0002876_abnormal_thyroid_physiology1.43345617
46MP0002067_abnormal_sensory_capabilities1.43083295
47MP0001984_abnormal_olfaction1.42795295
48MP0000631_abnormal_neuroendocrine_gland1.41595875
49MP0002184_abnormal_innervation1.38659734
50MP0005670_abnormal_white_adipose1.37805696
51MP0001440_abnormal_grooming_behavior1.32441941
52MP0006072_abnormal_retinal_apoptosis1.31930381
53MP0001346_abnormal_lacrimal_gland1.31625948
54MP0002736_abnormal_nociception_after1.31568222
55MP0005499_abnormal_olfactory_system1.27376437
56MP0005394_taste/olfaction_phenotype1.27376437
57MP0002638_abnormal_pupillary_reflex1.26365203
58MP0003633_abnormal_nervous_system1.26082004
59MP0003329_amyloid_beta_deposits1.25985939
60MP0004924_abnormal_behavior1.25267145
61MP0005386_behavior/neurological_phenoty1.25267145
62MP0000026_abnormal_inner_ear1.24459375
63MP0001501_abnormal_sleep_pattern1.23785723
64MP0010386_abnormal_urinary_bladder1.23768892
65MP0002229_neurodegeneration1.21269534
66MP0000383_abnormal_hair_follicle1.20978706
67MP0005410_abnormal_fertilization1.16621700
68MP0001529_abnormal_vocalization1.16486988
69MP0003123_paternal_imprinting1.15366177
70MP0003941_abnormal_skin_development1.15286051
71MP0004142_abnormal_muscle_tone1.13569322
72MP0003631_nervous_system_phenotype1.12986907
73MP0001963_abnormal_hearing_physiology1.11848176
74MP0004133_heterotaxia1.11345191
75MP0002751_abnormal_autonomic_nervous1.10913087
76MP0001970_abnormal_pain_threshold1.10576596
77MP0002752_abnormal_somatic_nervous1.10187901
78MP0005451_abnormal_body_composition1.09433634
79MP0003938_abnormal_ear_development1.09363290
80MP0000678_abnormal_parathyroid_gland1.08319480
81MP0002938_white_spotting1.07370473
82MP0003698_abnormal_male_reproductive1.05453001
83MP0008058_abnormal_DNA_repair1.02721276
84MP0005253_abnormal_eye_physiology1.02339251
85MP0001502_abnormal_circadian_rhythm1.01978023
86MP0008057_abnormal_DNA_replication1.01859262
87MP0003121_genomic_imprinting1.01019184
88MP0002249_abnormal_larynx_morphology1.00168467
89MP0002069_abnormal_eating/drinking_beha0.99941177
90MP0008789_abnormal_olfactory_epithelium0.99900989
91MP0005379_endocrine/exocrine_gland_phen0.98341473
92MP0002733_abnormal_thermal_nociception0.98340312
93MP0000955_abnormal_spinal_cord0.97709490
94MP0002882_abnormal_neuron_morphology0.97100841
95MP0005220_abnormal_exocrine_pancreas0.96189175
96MP0000604_amyloidosis0.95174284
97MP0001905_abnormal_dopamine_level0.92365821
98MP0001177_atelectasis0.92091634
99MP0000920_abnormal_myelination0.91855540
100MP0005075_abnormal_melanosome_morpholog0.90219969
101MP0000579_abnormal_nail_morphology0.90051494
102MP0008260_abnormal_autophagy0.85024215
103MP0002177_abnormal_outer_ear0.83914267
104MP0003861_abnormal_nervous_system0.83500683
105MP0000049_abnormal_middle_ear0.81288440
106MP0005310_abnormal_salivary_gland0.81141031
107MP0003879_abnormal_hair_cell0.80066489
108MP0006035_abnormal_mitochondrial_morpho0.79509095
109MP0000681_abnormal_thyroid_gland0.79404708
110MP0004885_abnormal_endolymph0.78682495
111MP0004185_abnormal_adipocyte_glucose0.77293402
112MP0003111_abnormal_nucleus_morphology0.77205844
113MP0002095_abnormal_skin_pigmentation0.75944222
114MP0003937_abnormal_limbs/digits/tail_de0.75750576
115MP0003122_maternal_imprinting0.74683252
116MP0001485_abnormal_pinna_reflex0.73792557
117MP0002210_abnormal_sex_determination0.73626372
118MP0003878_abnormal_ear_physiology0.73493169
119MP0005377_hearing/vestibular/ear_phenot0.73493169
120MP0002066_abnormal_motor_capabilities/c0.72473035
121MP0002233_abnormal_nose_morphology0.72429431
122MP0002152_abnormal_brain_morphology0.71590567
123MP0008874_decreased_physiological_sensi0.71264708
124MP0001929_abnormal_gametogenesis0.69303951
125MP0003890_abnormal_embryonic-extraembry0.69062667
126MP0003868_abnormal_feces_composition0.68288421
127MP0009278_abnormal_bone_marrow0.65106109
128MP0008872_abnormal_physiological_respon0.63363803
129MP0003632_abnormal_nervous_system0.63273097
130MP0003690_abnormal_glial_cell0.60548529
131MP0004043_abnormal_pH_regulation0.60179292
132MP0002163_abnormal_gland_morphology0.59076000
133* MP0002873_normal_phenotype0.55360137
134* MP0002169_no_abnormal_phenotype0.54947594
135MP0004233_abnormal_muscle_weight0.53815096
136MP0010769_abnormal_survival0.53533165

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.67735558
2Febrile seizures (HP:0002373)4.36647233
3Abnormality of alanine metabolism (HP:0010916)4.15667101
4Hyperalaninemia (HP:0003348)4.15667101
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.15667101
6Abnormality of the renal collecting system (HP:0004742)4.12748796
7Focal motor seizures (HP:0011153)4.03641707
8Chromsome breakage (HP:0040012)4.03358844
9Duplicated collecting system (HP:0000081)3.89761350
10Action tremor (HP:0002345)3.78502779
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.48485545
12Absent/shortened dynein arms (HP:0200106)3.48485545
13Urinary bladder sphincter dysfunction (HP:0002839)3.29282971
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.24026804
15Abnormal ciliary motility (HP:0012262)3.20504372
16Spastic gait (HP:0002064)3.16622052
17Congenital stationary night blindness (HP:0007642)3.12977665
18Septo-optic dysplasia (HP:0100842)3.12752748
19Decreased central vision (HP:0007663)2.99410087
20Cerebral hypomyelination (HP:0006808)2.98859187
21Abnormal respiratory motile cilium physiology (HP:0012261)2.93686530
22Nephronophthisis (HP:0000090)2.92114458
23Visual hallucinations (HP:0002367)2.90300522
24Ankle clonus (HP:0011448)2.87873918
25Upper limb muscle weakness (HP:0003484)2.87391945
26Urinary urgency (HP:0000012)2.83029128
27Abnormality of the renal medulla (HP:0100957)2.82083503
28Tubulointerstitial nephritis (HP:0001970)2.78948006
29Truncal ataxia (HP:0002078)2.73794347
30Osteomalacia (HP:0002749)2.73500248
31Abnormal respiratory epithelium morphology (HP:0012253)2.70122186
32Abnormal respiratory motile cilium morphology (HP:0005938)2.70122186
33Broad-based gait (HP:0002136)2.69592608
34Mutism (HP:0002300)2.69075237
35Impaired vibration sensation in the lower limbs (HP:0002166)2.67308091
36Optic nerve hypoplasia (HP:0000609)2.64161454
37Genetic anticipation (HP:0003743)2.63031458
38Poor eye contact (HP:0000817)2.62214877
39Polyphagia (HP:0002591)2.59444875
40Abnormality of the labia minora (HP:0012880)2.56231763
41Supranuclear gaze palsy (HP:0000605)2.56036804
42Carpal bone hypoplasia (HP:0001498)2.55728363
43Chronic hepatic failure (HP:0100626)2.48249614
44Myokymia (HP:0002411)2.46933125
45True hermaphroditism (HP:0010459)2.41951609
46Fair hair (HP:0002286)2.35038878
47Absence seizures (HP:0002121)2.34940289
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.34733098
49Attenuation of retinal blood vessels (HP:0007843)2.34248750
50Progressive cerebellar ataxia (HP:0002073)2.33766538
51Pancreatic fibrosis (HP:0100732)2.30984720
52Abnormality of the corticospinal tract (HP:0002492)2.29503956
53Focal seizures (HP:0007359)2.28794278
54Male pseudohermaphroditism (HP:0000037)2.28099252
55Dialeptic seizures (HP:0011146)2.27498086
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26562309
57Protruding tongue (HP:0010808)2.25699165
58Duplication of thumb phalanx (HP:0009942)2.25365020
59Prostate neoplasm (HP:0100787)2.24265545
60Abnormality of DNA repair (HP:0003254)2.24031964
61Sleep apnea (HP:0010535)2.23470809
62Limb dystonia (HP:0002451)2.21799825
63Abnormal eating behavior (HP:0100738)2.21488484
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19652182
65Congenital hepatic fibrosis (HP:0002612)2.16927431
66Impaired social interactions (HP:0000735)2.16749923
67Abnormal social behavior (HP:0012433)2.16749923
68Abnormal hair whorl (HP:0010721)2.16692613
69Absent speech (HP:0001344)2.15225939
70Absent eyebrow (HP:0002223)2.14906286
71Dysmetria (HP:0001310)2.10699527
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.10287641
73Reticulocytopenia (HP:0001896)2.10178624
74Epileptiform EEG discharges (HP:0011182)2.09434877
75Concave nail (HP:0001598)2.06260533
76Generalized hypopigmentation of hair (HP:0011358)2.06004206
77Abnormality of binocular vision (HP:0011514)2.04958823
78Diplopia (HP:0000651)2.04958823
79Lissencephaly (HP:0001339)2.04905918
80Lip pit (HP:0100267)2.04869056
81Gait imbalance (HP:0002141)2.04720988
82Morphological abnormality of the pyramidal tract (HP:0002062)2.04510420
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03574389
84Pancreatic cysts (HP:0001737)2.03299822
85Deep palmar crease (HP:0006191)2.03118168
86Epileptic encephalopathy (HP:0200134)2.03012234
87Thoracic kyphosis (HP:0002942)2.03009473
88Meckel diverticulum (HP:0002245)2.02738862
89Abnormality of the axillary hair (HP:0100134)2.02420495
90Abnormality of secondary sexual hair (HP:0009888)2.02420495
91Medulloblastoma (HP:0002885)2.02420188
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02355130
93Degeneration of the lateral corticospinal tracts (HP:0002314)2.02355130
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01601724
95Delusions (HP:0000746)2.01388688
96Abnormality of incisor morphology (HP:0011063)2.01145600
97Depression (HP:0000716)2.00074982
98Abnormality of cochlea (HP:0000375)1.99661499
99Hyperkalemia (HP:0002153)1.98919762
100Abnormality of the lower motor neuron (HP:0002366)1.98842372
101Abnormality of the preputium (HP:0100587)1.97681554
102EEG with generalized epileptiform discharges (HP:0011198)1.97085865
103Abnormality of the septum pellucidum (HP:0007375)1.96417830
104Spastic tetraplegia (HP:0002510)1.95970606
105Medial flaring of the eyebrow (HP:0010747)1.95825231
106Hypsarrhythmia (HP:0002521)1.93890226
107Abnormality of the ileum (HP:0001549)1.93562528
108Molar tooth sign on MRI (HP:0002419)1.91993449
109Abnormality of midbrain morphology (HP:0002418)1.91993449
110Median cleft lip (HP:0000161)1.91820724
111Annular pancreas (HP:0001734)1.91463991
112Intention tremor (HP:0002080)1.91339777
113Stereotypic behavior (HP:0000733)1.91296247
114Atelectasis (HP:0100750)1.91228365
115Hyperphosphatemia (HP:0002905)1.91046215
116Dyskinesia (HP:0100660)1.90476448
117Nephrogenic diabetes insipidus (HP:0009806)1.90150567
118Clubbing of toes (HP:0100760)1.89039968
119Hyperventilation (HP:0002883)1.88803111
120Neuronal loss in central nervous system (HP:0002529)1.88202716
121Clonus (HP:0002169)1.87963285
122Agnosia (HP:0010524)1.87548701
123Apathy (HP:0000741)1.87518515
124Obstructive sleep apnea (HP:0002870)1.87425337
125Absent septum pellucidum (HP:0001331)1.86463243
126CNS hypomyelination (HP:0003429)1.86264098
127Hypoplastic nipples (HP:0002557)1.85978501
128Renal agenesis (HP:0000104)1.84999360
129Cupped ear (HP:0000378)1.84666739
130Hypothermia (HP:0002045)1.83827819
131Morphological abnormality of the middle ear (HP:0008609)1.83612306
132Aplasia cutis congenita (HP:0001057)1.82021929
133Abnormality of the renal cortex (HP:0011035)1.81583791
134Nephroblastoma (Wilms tumor) (HP:0002667)1.80329063
135Aplasia of the musculature (HP:0100854)1.80180467
136Diminished motivation (HP:0000745)1.79856031
137Acute lymphatic leukemia (HP:0006721)1.79413822
138Reduced antithrombin III activity (HP:0001976)1.79263331
139Abnormality of the lacrimal duct (HP:0011481)1.79198115
140Drooling (HP:0002307)1.78847024
141Postaxial foot polydactyly (HP:0001830)1.78667387
142Preaxial hand polydactyly (HP:0001177)1.78605990
143Optic nerve coloboma (HP:0000588)1.78318544
144Atonic seizures (HP:0010819)1.78097044
145Morphological abnormality of the inner ear (HP:0011390)1.77642557
146Abnormality of hair growth rate (HP:0011363)1.77428535
147Slow-growing hair (HP:0002217)1.77428535
148Gaze-evoked nystagmus (HP:0000640)1.76617024
149Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.75244975
150Impaired vibratory sensation (HP:0002495)1.74357488
151Paraplegia (HP:0010550)1.74252505
152Severe visual impairment (HP:0001141)1.73221779
153Constricted visual fields (HP:0001133)1.72410996
154Retinal dysplasia (HP:0007973)1.71701096
155Abnormality of the nasolacrimal system (HP:0000614)1.71113676
156Fetal akinesia sequence (HP:0001989)1.71032178
157Facial cleft (HP:0002006)1.70748502
158Congenital sensorineural hearing impairment (HP:0008527)1.70444739
159Rhinitis (HP:0012384)1.70313967
160Cutaneous finger syndactyly (HP:0010554)1.70117651
161Tented upper lip vermilion (HP:0010804)1.69375293
162Peripheral hypomyelination (HP:0007182)1.68894408
163Ependymoma (HP:0002888)1.68730377
164Short chin (HP:0000331)1.68692704
165Hypomagnesemia (HP:0002917)1.68681234
166Oligomenorrhea (HP:0000876)1.68064367
167Nasolacrimal duct obstruction (HP:0000579)1.67340050
168Parakeratosis (HP:0001036)1.67013495
169Conical tooth (HP:0000698)1.66496914
170Aplasia/Hypoplasia of the fovea (HP:0008060)1.66421490
171Hypoplasia of the fovea (HP:0007750)1.66421490
172Hypoplasia of the corpus callosum (HP:0002079)1.65767227
173Blue irides (HP:0000635)1.64769210
174Triphalangeal thumb (HP:0001199)1.64766731
175Unsteady gait (HP:0002317)1.64618981
176Type I transferrin isoform profile (HP:0003642)1.63325922
177Status epilepticus (HP:0002133)1.62989687
178Thyroid-stimulating hormone excess (HP:0002925)1.62956634
179Absent rod-and cone-mediated responses on ERG (HP:0007688)1.62720674
180Embryonal renal neoplasm (HP:0011794)1.62145472
181Tubulointerstitial abnormality (HP:0001969)1.62033286
182Excessive salivation (HP:0003781)1.61796384
183Generalized tonic-clonic seizures (HP:0002069)1.61525354
184Progressive microcephaly (HP:0000253)1.60750946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.03103866
2TNIK3.81045379
3EPHA43.78785285
4MAP3K103.59587869
5NTRK33.58584158
6CDK193.12058955
7STK163.06973971
8TESK22.46649124
9PRKD32.40253543
10MAP2K72.20795761
11BRD42.16993344
12MAP3K111.98066169
13CAMKK11.96195027
14MKNK21.96110892
15INSRR1.95938125
16PRPF4B1.95544536
17MARK11.93646166
18RIPK11.91008304
19DAPK11.90886755
20ZAK1.88066266
21EIF2AK21.86920760
22BRAF1.82008158
23NEK61.75946263
24MAPK131.72887781
25NTRK21.72099546
26SIK21.65295837
27AKT31.61585576
28CDK31.54878020
29GRK11.53648698
30IRAK31.53385943
31MAP3K91.52467478
32BCKDK1.47846522
33IRAK21.45776757
34CSNK1G31.45396797
35SRPK11.43103324
36CSNK1G21.39990028
37CSNK1A1L1.35038047
38ARAF1.34680426
39CDC42BPA1.34312850
40ADRBK21.30106790
41MAP3K41.24967611
42SGK31.24196032
43WNK31.24063501
44FES1.23788722
45TXK1.23727678
46NUAK11.21142549
47TLK11.19787899
48PRKD21.18073994
49TAOK21.12741177
50PKN11.11586557
51LATS11.11236970
52YES11.09809710
53PRKCI1.06066180
54CSNK1G11.04647460
55MAP3K121.01004481
56TYRO31.00755994
57IRAK40.99177789
58PNCK0.96240705
59TNK20.95452165
60TRIM280.95259140
61STK390.95170817
62BMPR20.94550050
63CAMK2B0.94296779
64DAPK20.94118940
65IRAK10.91951883
66BMPR1B0.91295079
67PRKCH0.89118668
68CAMK2A0.85932201
69CAMK40.85503008
70MARK20.84814851
71TAOK10.83533150
72CDK180.82372439
73CDK150.82225029
74MAPK150.81811513
75PINK10.81679134
76MKNK10.81045594
77RIPK40.80534738
78PIM20.79546661
79CDK140.79247168
80CDK11A0.78856715
81SIK30.78573461
82PRKCG0.76189133
83PRKCE0.73584957
84DAPK30.71329460
85STK380.70501868
86OXSR10.69851742
87CAMK10.69355833
88CLK10.69287450
89VRK10.67641455
90EPHA30.67501240
91PRKCZ0.67305383
92SGK10.65106518
93AURKA0.64232266
94WNK10.63907642
95CAMK1G0.63621565
96DYRK1A0.63296643
97WNK40.62968979
98CAMK1D0.62328462
99ATR0.61650500
100UHMK10.60937886
101TRIB30.60791215
102PLK40.59835372
103BCR0.59822435
104MAP3K30.59546307
105SGK20.58385341
106MAP3K140.57905302
107CDK90.56348021
108GRK70.56168124
109CDK50.55158033
110DYRK20.52267986
111NLK0.52240522
112MAP2K40.51665235
113TESK10.51269304
114PRKG10.50068801
115MAP3K50.48893027
116PAK30.48783684
117CCNB10.48694692
118MAPK70.46619311
119RPS6KA20.46300783
120PDK10.45834287
121CDC70.44961041
122CAMK2D0.44384873
123EPHA20.41423819
124HIPK20.41209466
125DYRK1B0.39894771
126SGK4940.39852663
127SGK2230.39852663
128MUSK0.39616151
129* PRKACA0.38717632
130PRKCQ0.38424192
131PLK20.37760519
132PKN20.35601326
133TAOK30.35032832
134RPS6KA30.34061390
135CHEK20.33557404
136GRK50.33503922
137PRKCB0.33366219
138DYRK30.33205694
139CAMK2G0.33171994
140GSK3B0.31970355
141MAP4K10.31369720
142STK110.31197740
143MINK10.30699593
144* PRKCA0.30283928
145MAPK80.30109739
146PAK60.29905610
147CAMKK20.29783538
148FGR0.28754086
149CSNK1E0.28589681
150CSNK1A10.28532229
151STK38L0.27414913
152PIK3CG0.26771487

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08242650
2Phototransduction_Homo sapiens_hsa047443.03269571
3Taste transduction_Homo sapiens_hsa047422.45175088
4Morphine addiction_Homo sapiens_hsa050322.40735092
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.40173609
6Glutamatergic synapse_Homo sapiens_hsa047242.39356622
7Fanconi anemia pathway_Homo sapiens_hsa034602.29915382
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27469240
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19043671
10Vibrio cholerae infection_Homo sapiens_hsa051102.17104679
11Serotonergic synapse_Homo sapiens_hsa047262.02695197
12Olfactory transduction_Homo sapiens_hsa047401.96959285
13Circadian entrainment_Homo sapiens_hsa047131.91654631
14Amphetamine addiction_Homo sapiens_hsa050311.91612823
15GABAergic synapse_Homo sapiens_hsa047271.73121485
16Calcium signaling pathway_Homo sapiens_hsa040201.65612530
17Axon guidance_Homo sapiens_hsa043601.65002817
18Insulin secretion_Homo sapiens_hsa049111.55818857
19Salivary secretion_Homo sapiens_hsa049701.55474005
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54808066
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50265395
22Long-term potentiation_Homo sapiens_hsa047201.49204408
23Pancreatic secretion_Homo sapiens_hsa049721.44642165
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41352306
25Cocaine addiction_Homo sapiens_hsa050301.40642177
26Synaptic vesicle cycle_Homo sapiens_hsa047211.40230404
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36003473
28Dopaminergic synapse_Homo sapiens_hsa047281.31519700
29Cholinergic synapse_Homo sapiens_hsa047251.29103859
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.28685784
31Base excision repair_Homo sapiens_hsa034101.25445620
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23738398
33Linoleic acid metabolism_Homo sapiens_hsa005911.22776030
34Ether lipid metabolism_Homo sapiens_hsa005651.22450527
35Long-term depression_Homo sapiens_hsa047301.20826880
36Renin secretion_Homo sapiens_hsa049241.20006278
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17536934
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16306611
39Collecting duct acid secretion_Homo sapiens_hsa049661.15847973
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15549648
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14407254
42Sphingolipid metabolism_Homo sapiens_hsa006001.14069575
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06679257
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04665642
45Vitamin B6 metabolism_Homo sapiens_hsa007501.01300698
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01075826
47Oxytocin signaling pathway_Homo sapiens_hsa049210.97561426
48Homologous recombination_Homo sapiens_hsa034400.93548466
49Oocyte meiosis_Homo sapiens_hsa041140.93083494
50Wnt signaling pathway_Homo sapiens_hsa043100.91225232
51cAMP signaling pathway_Homo sapiens_hsa040240.90464876
52Autoimmune thyroid disease_Homo sapiens_hsa053200.90390152
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.89735395
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89178586
55Systemic lupus erythematosus_Homo sapiens_hsa053220.88338486
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.87990585
57Arachidonic acid metabolism_Homo sapiens_hsa005900.87128586
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86810351
59Graft-versus-host disease_Homo sapiens_hsa053320.86257954
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.85996945
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85171488
62Gastric acid secretion_Homo sapiens_hsa049710.81611147
63Non-homologous end-joining_Homo sapiens_hsa034500.80233590
64Sulfur relay system_Homo sapiens_hsa041220.79002935
65ABC transporters_Homo sapiens_hsa020100.78349349
66Choline metabolism in cancer_Homo sapiens_hsa052310.78339570
67Inositol phosphate metabolism_Homo sapiens_hsa005620.77420485
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76418724
69Ovarian steroidogenesis_Homo sapiens_hsa049130.72761671
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.72540309
71Melanogenesis_Homo sapiens_hsa049160.72179067
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.69561968
73Ribosome_Homo sapiens_hsa030100.69245004
74Basal transcription factors_Homo sapiens_hsa030220.69060025
75ErbB signaling pathway_Homo sapiens_hsa040120.68846367
76Type I diabetes mellitus_Homo sapiens_hsa049400.67843956
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66677746
78Basal cell carcinoma_Homo sapiens_hsa052170.66398760
79Ras signaling pathway_Homo sapiens_hsa040140.66013376
80Arginine biosynthesis_Homo sapiens_hsa002200.65651115
81Vitamin digestion and absorption_Homo sapiens_hsa049770.65471711
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.64610245
83Asthma_Homo sapiens_hsa053100.64072775
84GnRH signaling pathway_Homo sapiens_hsa049120.63881473
85Selenocompound metabolism_Homo sapiens_hsa004500.63822886
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63064196
87Type II diabetes mellitus_Homo sapiens_hsa049300.62659567
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.62336225
89Purine metabolism_Homo sapiens_hsa002300.61774308
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61714775
91Glioma_Homo sapiens_hsa052140.61271491
92Protein digestion and absorption_Homo sapiens_hsa049740.60249643
93Circadian rhythm_Homo sapiens_hsa047100.58416096
94Peroxisome_Homo sapiens_hsa041460.57454984
95Galactose metabolism_Homo sapiens_hsa000520.57083202
96Alcoholism_Homo sapiens_hsa050340.56850225
97Biosynthesis of amino acids_Homo sapiens_hsa012300.55679872
98Estrogen signaling pathway_Homo sapiens_hsa049150.55182519
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55101737
100African trypanosomiasis_Homo sapiens_hsa051430.54233113
101Gap junction_Homo sapiens_hsa045400.52875286
102RNA polymerase_Homo sapiens_hsa030200.50772814
103MAPK signaling pathway_Homo sapiens_hsa040100.50726843
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49260336
105Hedgehog signaling pathway_Homo sapiens_hsa043400.48735255
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48721689
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47935037
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45928753
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45012288
110Glycerolipid metabolism_Homo sapiens_hsa005610.44660064
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.44571443
112Hematopoietic cell lineage_Homo sapiens_hsa046400.43886738
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42837400
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42226062
115Rheumatoid arthritis_Homo sapiens_hsa053230.40570342
116Primary immunodeficiency_Homo sapiens_hsa053400.40206672
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39741297
118Oxidative phosphorylation_Homo sapiens_hsa001900.38728869
119Rap1 signaling pathway_Homo sapiens_hsa040150.37780328
120Arginine and proline metabolism_Homo sapiens_hsa003300.37367465
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36922338
122Allograft rejection_Homo sapiens_hsa053300.36780765
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36528747
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36315875
125Alzheimers disease_Homo sapiens_hsa050100.35110260
126T cell receptor signaling pathway_Homo sapiens_hsa046600.33823371
127Lysine degradation_Homo sapiens_hsa003100.33618531
128Parkinsons disease_Homo sapiens_hsa050120.33588173
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33111939
130Regulation of autophagy_Homo sapiens_hsa041400.32370585
131mRNA surveillance pathway_Homo sapiens_hsa030150.32024491
132Butanoate metabolism_Homo sapiens_hsa006500.30569947
133beta-Alanine metabolism_Homo sapiens_hsa004100.29797551
134Huntingtons disease_Homo sapiens_hsa050160.29071086
135mTOR signaling pathway_Homo sapiens_hsa041500.29048417
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28155626
137AMPK signaling pathway_Homo sapiens_hsa041520.26844289
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24312453
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.23553677

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