DTNBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05514404
2negative regulation of cell killing (GO:0031342)5.05514404
3ribosomal small subunit assembly (GO:0000028)4.63873181
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.62445035
5fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.84257235
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70070535
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70070535
8oxaloacetate metabolic process (GO:0006107)3.53913858
9antigen processing and presentation via MHC class Ib (GO:0002475)3.51944938
10tricarboxylic acid cycle (GO:0006099)3.51153854
112-oxoglutarate metabolic process (GO:0006103)3.51091094
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.50995291
13DNA deamination (GO:0045006)3.48750502
14negative regulation of phagocytosis (GO:0050765)3.38864542
15NADH metabolic process (GO:0006734)3.28936582
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26505373
17positive thymic T cell selection (GO:0045059)3.21018091
18fatty acid beta-oxidation (GO:0006635)3.20873173
19positive regulation of B cell differentiation (GO:0045579)3.18374857
20B cell mediated immunity (GO:0019724)3.15113364
21cellular response to zinc ion (GO:0071294)3.12255283
22oxidative phosphorylation (GO:0006119)3.08016847
23antigen processing and presentation of endogenous antigen (GO:0019883)3.05036556
24endosome to pigment granule transport (GO:0043485)3.04226550
25endosome to melanosome transport (GO:0035646)3.04226550
26tricarboxylic acid metabolic process (GO:0072350)3.03974491
27fatty acid transmembrane transport (GO:1902001)3.02467055
28positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97684067
29pentose-phosphate shunt (GO:0006098)2.97637392
30carnitine shuttle (GO:0006853)2.95933044
31negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.95503288
32regulation of sequestering of triglyceride (GO:0010889)2.93732548
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93120720
34valine metabolic process (GO:0006573)2.91097327
35negative regulation of B cell apoptotic process (GO:0002903)2.90636298
36carnitine metabolic process (GO:0009437)2.86418528
37definitive hemopoiesis (GO:0060216)2.86314999
38response to interferon-beta (GO:0035456)2.86221349
39negative regulation of T cell mediated immunity (GO:0002710)2.85950906
40lysine metabolic process (GO:0006553)2.85692192
41lysine catabolic process (GO:0006554)2.85692192
42viral transcription (GO:0019083)2.85414650
43regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84185635
44killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.84097374
45disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.84097374
46mitochondrial calcium ion transport (GO:0006851)2.82482420
47negative regulation of interleukin-12 production (GO:0032695)2.80579696
48carnitine transmembrane transport (GO:1902603)2.80347525
49positive regulation of lamellipodium assembly (GO:0010592)2.79017258
50carnitine transport (GO:0015879)2.78981433
51amino-acid betaine transport (GO:0015838)2.78981433
52fatty acid catabolic process (GO:0009062)2.76832488
53regulation of interferon-beta biosynthetic process (GO:0045357)2.75052333
54fatty acid oxidation (GO:0019395)2.74359374
55production of molecular mediator involved in inflammatory response (GO:0002532)2.73933269
56translational termination (GO:0006415)2.73219817
57cellular response to interleukin-15 (GO:0071350)2.72956752
58positive regulation of gamma-delta T cell activation (GO:0046645)2.71512326
59positive regulation of defense response to virus by host (GO:0002230)2.71135840
60neutrophil activation involved in immune response (GO:0002283)2.71057494
61piRNA metabolic process (GO:0034587)2.70318725
62negative regulation of lymphocyte mediated immunity (GO:0002707)2.69903355
63positive regulation of antigen processing and presentation (GO:0002579)2.69399623
64response to protozoan (GO:0001562)2.69121609
65purine-containing compound salvage (GO:0043101)2.69111127
66lipid oxidation (GO:0034440)2.68669296
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68415777
68immunoglobulin mediated immune response (GO:0016064)2.68191102
69toxin transport (GO:1901998)2.67909525
70regulation of fatty acid oxidation (GO:0046320)2.67743621
71cellular response to interferon-beta (GO:0035458)2.67295091
72mast cell activation (GO:0045576)2.63963239
73negative regulation of innate immune response (GO:0045824)2.63160903
74regulation of gamma-delta T cell activation (GO:0046643)2.62332519
75pinocytosis (GO:0006907)2.61945683
76response to interferon-alpha (GO:0035455)2.61825295
77quaternary ammonium group transport (GO:0015697)2.61699718
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61166028
79NADPH regeneration (GO:0006740)2.60555204
80type I interferon signaling pathway (GO:0060337)2.60344651
81cellular response to type I interferon (GO:0071357)2.60344651
82response to type I interferon (GO:0034340)2.59680082
83detection of bacterium (GO:0016045)2.59351902
84positive regulation of actin cytoskeleton reorganization (GO:2000251)2.59189176
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.59128437
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58892706
87regulation of B cell receptor signaling pathway (GO:0050855)2.58457181
88B cell receptor signaling pathway (GO:0050853)2.57308881
89respiratory electron transport chain (GO:0022904)2.56866528
90positive T cell selection (GO:0043368)2.56752167
91response to thyroid hormone (GO:0097066)2.55231596
92regulation of cholesterol storage (GO:0010885)2.54770833
93respiratory burst (GO:0045730)2.54582790
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.54454420
95alpha-linolenic acid metabolic process (GO:0036109)2.54435146
96protein complex biogenesis (GO:0070271)2.53241999
97interferon-gamma-mediated signaling pathway (GO:0060333)2.51823443
98regulation of T cell mediated cytotoxicity (GO:0001914)2.50872400
99translational elongation (GO:0006414)2.50553082
100ADP metabolic process (GO:0046031)2.50180611
101regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.49556349
102pseudouridine synthesis (GO:0001522)2.48959930
103amino-acid betaine metabolic process (GO:0006577)2.48266951
104GDP-mannose metabolic process (GO:0019673)2.47598245
105macrophage activation involved in immune response (GO:0002281)2.47129658
106myeloid cell activation involved in immune response (GO:0002275)2.47016582
107deoxyribose phosphate biosynthetic process (GO:0046385)2.46807693
1082-deoxyribonucleotide biosynthetic process (GO:0009265)2.46807693
109negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.46638202
110ribosomal small subunit biogenesis (GO:0042274)2.46254100
111regulation of antigen processing and presentation (GO:0002577)2.46011847
112negative regulation of myeloid cell apoptotic process (GO:0033033)2.45660001
113positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.45243310
114electron transport chain (GO:0022900)2.44807713
115response to peptidoglycan (GO:0032494)2.44188489
116positive regulation of interferon-alpha production (GO:0032727)2.44111066
117negative regulation of leukocyte mediated immunity (GO:0002704)2.42836665
118mature B cell differentiation involved in immune response (GO:0002313)2.42682315
119angiogenesis involved in wound healing (GO:0060055)2.42644254
120DNA methylation involved in gamete generation (GO:0043046)2.42275417
121tumor necrosis factor-mediated signaling pathway (GO:0033209)2.41915481
122actin nucleation (GO:0045010)2.41303426
123deoxyribose phosphate catabolic process (GO:0046386)2.40945882
124regulation of relaxation of muscle (GO:1901077)2.39367672
125detection of other organism (GO:0098543)2.39335221
126barbed-end actin filament capping (GO:0051016)2.39332575
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.39311138
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.39311138
129NADH dehydrogenase complex assembly (GO:0010257)2.39311138
130defense response to protozoan (GO:0042832)2.38920020
131response to interleukin-15 (GO:0070672)2.38034301
132mitochondrial respiratory chain complex assembly (GO:0033108)2.37811416
133chaperone mediated protein folding requiring cofactor (GO:0051085)2.36698185
134T cell apoptotic process (GO:0070231)2.35349719
135monocarboxylic acid catabolic process (GO:0072329)2.34864979
136necroptotic process (GO:0070266)2.34857050
137sarcomere organization (GO:0045214)2.34349439
138mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.34222064
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.33056480
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.33056480
141modulation by symbiont of host immune response (GO:0052553)2.33056480
142positive regulation by symbiont of host defense response (GO:0052509)2.33056480
143modulation by symbiont of host defense response (GO:0052031)2.33056480
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.33056480
145* platelet dense granule organization (GO:0060155)2.32276519
146aerobic respiration (GO:0009060)2.32148546
147regulation of respiratory burst (GO:0060263)2.32011399
148deoxyribonucleotide catabolic process (GO:0009264)2.30891140
149regulation of B cell apoptotic process (GO:0002902)2.30868887
150regulation of mast cell degranulation (GO:0043304)2.30840410
151succinate metabolic process (GO:0006105)2.30698424
152regulation of gamma-delta T cell differentiation (GO:0045586)2.30647395
153regulation of coenzyme metabolic process (GO:0051196)2.30497229
154regulation of cofactor metabolic process (GO:0051193)2.30497229
155glucose 6-phosphate metabolic process (GO:0051156)2.30373675
156nucleotide salvage (GO:0043173)2.29876903
157positive regulation of T cell mediated cytotoxicity (GO:0001916)2.29851881
158positive regulation of lamellipodium organization (GO:1902745)2.29371777
159metallo-sulfur cluster assembly (GO:0031163)2.29325085
160iron-sulfur cluster assembly (GO:0016226)2.29325085
161megakaryocyte development (GO:0035855)2.29136820
162cellular response to thyroid hormone stimulus (GO:0097067)2.28881751
163regulation of acyl-CoA biosynthetic process (GO:0050812)2.28741528
164regulation of interferon-alpha production (GO:0032647)2.28456535
165negative regulation of interleukin-17 production (GO:0032700)2.28074743
166positive regulation of T cell differentiation in thymus (GO:0033089)2.28014290
167negative regulation of erythrocyte differentiation (GO:0045647)2.27825094
168negative regulation of type I interferon production (GO:0032480)2.27703832
169cytochrome complex assembly (GO:0017004)2.27556219
170purine nucleotide salvage (GO:0032261)2.27370067
171negative regulation of DNA-templated transcription, elongation (GO:0032785)2.27227418
172respiratory chain complex IV assembly (GO:0008535)2.26618119
173pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.26360718
174positive regulation of protein homooligomerization (GO:0032464)2.25389643
175interferon-gamma production (GO:0032609)2.24753528
176base-excision repair, AP site formation (GO:0006285)2.24745891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.49783668
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47711781
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47134394
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40573984
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.29410529
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89715128
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.86137920
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72004197
9SCL_19346495_ChIP-Seq_HPC-7_Human2.67968705
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64419212
11* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59505690
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54963647
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50909145
14VDR_21846776_ChIP-Seq_THP-1_Human2.50770296
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34276759
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.14197922
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12810432
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12526035
19E2F7_22180533_ChIP-Seq_HELA_Human2.12334031
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.09708747
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09173982
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07481897
23PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03682992
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02639485
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93869302
26MYC_22102868_ChIP-Seq_BL_Human1.91540663
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89669733
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88898772
29* VDR_24763502_ChIP-Seq_THP-1_Human1.87869560
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87335019
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85501528
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.85193685
33SPI1_23547873_ChIP-Seq_NB4_Human1.85132370
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.83746920
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.83718129
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80540108
37VDR_23849224_ChIP-Seq_CD4+_Human1.77990670
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76948645
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74771667
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71808215
41* GABP_19822575_ChIP-Seq_HepG2_Human1.66988519
42BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.65624361
43CIITA_25753668_ChIP-Seq_RAJI_Human1.65609950
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65058924
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.64504272
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63064629
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62086462
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61822346
49MAF_26560356_Chip-Seq_TH1_Human1.61812010
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61767420
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61595462
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.60662106
53FOXP3_21729870_ChIP-Seq_TREG_Human1.60532292
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.60452381
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58940482
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54648934
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53158140
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52938794
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.51729191
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50652506
61* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50569500
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.49731035
63XRN2_22483619_ChIP-Seq_HELA_Human1.49693798
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.48725813
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48528437
66TCF7_22412390_ChIP-Seq_EML_Mouse1.47984485
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44784571
68DCP1A_22483619_ChIP-Seq_HELA_Human1.44454857
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43518492
70SPI1_23127762_ChIP-Seq_K562_Human1.42677525
71UTX_26944678_Chip-Seq_JUKART_Human1.41535035
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40869354
73LXR_22292898_ChIP-Seq_THP-1_Human1.38787369
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38024856
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37009442
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36146127
77LXR_22158963_ChIP-Seq_LIVER_Mouse1.36081283
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35833280
79* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35709774
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35288010
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.33020290
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31811979
83MYB_26560356_Chip-Seq_TH2_Human1.30304118
84P68_20966046_ChIP-Seq_HELA_Human1.30226929
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30062070
86MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28016297
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.27662007
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26401946
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26294737
90* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25414383
91* BCL6_27268052_Chip-Seq_Bcells_Human1.25213121
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23197076
93ZNF263_19887448_ChIP-Seq_K562_Human1.22504030
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22482507
95MYB_26560356_Chip-Seq_TH1_Human1.21166916
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.20222998
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20215596
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20131838
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19016632
100STAT1_20625510_ChIP-Seq_HELA_Human1.17952757
101* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17480108
102KDM5A_27292631_Chip-Seq_BREAST_Human1.17083185
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.16433601
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16293433
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16203228
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15814469
107* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15422956
108* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14221322
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.11415960
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10848542
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10368641
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09878902
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.09684593
114TTF2_22483619_ChIP-Seq_HELA_Human1.09250318
115MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09022582
116EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08061570
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07978041
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07441854
119KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06059071
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05065851
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04337576
122* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03949767
123* SPI1_20517297_ChIP-Seq_HL60_Human1.03674329
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03407812
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01881750
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00440762
127TFEB_21752829_ChIP-Seq_HELA_Human1.00161652
128MAF_26560356_Chip-Seq_TH2_Human0.98072947
129ETS1_20019798_ChIP-Seq_JURKAT_Human0.96891458
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96395241
131PU_27001747_Chip-Seq_BMDM_Mouse0.96087219
132* BCOR_27268052_Chip-Seq_Bcells_Human0.95063539
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.94314400
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94004930
135* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93948754
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93674445
137ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93244122
138CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91970604
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.91614835
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91111810
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91093516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000015_abnormal_ear_pigmentation3.21603115
2MP0003646_muscle_fatigue3.18572788
3MP0003191_abnormal_cellular_cholesterol2.75322194
4MP0002837_dystrophic_cardiac_calcinosis2.66732389
5MP0001835_abnormal_antigen_presentation2.57357419
6MP0003436_decreased_susceptibility_to2.42259369
7MP0000751_myopathy2.36022534
8MP0002396_abnormal_hematopoietic_system2.28706949
9MP0003806_abnormal_nucleotide_metabolis2.25036442
10MP0009785_altered_susceptibility_to2.22933033
11MP0004510_myositis2.18839274
12MP0009840_abnormal_foam_cell2.15654267
13MP0005058_abnormal_lysosome_morphology2.14827237
14MP0003724_increased_susceptibility_to2.09958752
15MP0003303_peritoneal_inflammation2.09046164
16MP0003763_abnormal_thymus_physiology2.07891962
17MP0005075_abnormal_melanosome_morpholog2.05557128
18MP0004130_abnormal_muscle_cell2.04035647
19MP0003183_abnormal_peptide_metabolism2.01682087
20MP0000343_altered_response_to1.99562792
21MP0000372_irregular_coat_pigmentation1.99228905
22MP0002132_abnormal_respiratory_system1.95487736
23MP0009333_abnormal_splenocyte_physiolog1.93238291
24* MP0005464_abnormal_platelet_physiology1.91057215
25MP0004084_abnormal_cardiac_muscle1.90907207
26MP0006036_abnormal_mitochondrial_physio1.89710219
27MP0002139_abnormal_hepatobiliary_system1.89410069
28MP0001853_heart_inflammation1.89070801
29MP0005397_hematopoietic_system_phenotyp1.84565591
30MP0001545_abnormal_hematopoietic_system1.84565591
31MP0002419_abnormal_innate_immunity1.84249577
32* MP0005025_abnormal_response_to1.81061735
33MP0005360_urolithiasis1.77777946
34MP0000685_abnormal_immune_system1.75665164
35MP0003787_abnormal_imprinting1.75270169
36MP0002148_abnormal_hypersensitivity_rea1.73872072
37MP0005330_cardiomyopathy1.66963040
38MP0005000_abnormal_immune_tolerance1.66534701
39MP0008260_abnormal_autophagy1.66219456
40MP0003693_abnormal_embryo_hatching1.61652813
41MP0000703_abnormal_thymus_morphology1.60553745
42MP0008877_abnormal_DNA_methylation1.58817708
43MP0004808_abnormal_hematopoietic_stem1.53342827
44MP0003075_altered_response_to1.51748187
45MP0003221_abnormal_cardiomyocyte_apopto1.49315656
46MP0010329_abnormal_lipoprotein_level1.48166679
47MP0002452_abnormal_antigen_presenting1.47942554
48MP0008469_abnormal_protein_level1.46553047
49MP0004147_increased_porphyrin_level1.44972118
50MP0009278_abnormal_bone_marrow1.44927567
51MP0005319_abnormal_enzyme/_coenzyme1.44074408
52MP0002723_abnormal_immune_serum1.41622432
53MP0000749_muscle_degeneration1.41403395
54MP0006035_abnormal_mitochondrial_morpho1.40801166
55MP0005365_abnormal_bile_salt1.39432717
56MP0008058_abnormal_DNA_repair1.38936494
57MP0005085_abnormal_gallbladder_physiolo1.38343737
58MP0005451_abnormal_body_composition1.37891213
59MP0004036_abnormal_muscle_relaxation1.36347813
60MP0001800_abnormal_humoral_immune1.35516066
61MP0003828_pulmonary_edema1.35094577
62* MP0002420_abnormal_adaptive_immunity1.34830739
63MP0005174_abnormal_tail_pigmentation1.34466549
64MP0006082_CNS_inflammation1.34270714
65* MP0001819_abnormal_immune_cell1.34137124
66MP0002166_altered_tumor_susceptibility1.33340613
67MP0005584_abnormal_enzyme/coenzyme_acti1.33119591
68MP0003186_abnormal_redox_activity1.31745458
69MP0002095_abnormal_skin_pigmentation1.31699897
70MP0004087_abnormal_muscle_fiber1.30996503
71MP0004233_abnormal_muscle_weight1.27845206
72MP0000689_abnormal_spleen_morphology1.24418698
73MP0005385_cardiovascular_system_phenoty1.24036563
74MP0001544_abnormal_cardiovascular_syste1.24036563
75* MP0002398_abnormal_bone_marrow1.23986357
76MP0003172_abnormal_lysosome_physiology1.23849313
77MP0001845_abnormal_inflammatory_respons1.22531997
78MP0005166_decreased_susceptibility_to1.21680460
79MP0001790_abnormal_immune_system1.21375070
80MP0005387_immune_system_phenotype1.21375070
81MP0008875_abnormal_xenobiotic_pharmacok1.19435762
82MP0004215_abnormal_myocardial_fiber1.19141649
83MP0000750_abnormal_muscle_regeneration1.18827504
84MP0001533_abnormal_skeleton_physiology1.17619335
85MP0003866_abnormal_defecation1.17144985
86MP0003656_abnormal_erythrocyte_physiolo1.17096796
87MP0000716_abnormal_immune_system1.15448767
88MP0004484_altered_response_of1.15408981
89MP0008438_abnormal_cutaneous_collagen1.12155634
90MP0000465_gastrointestinal_hemorrhage1.11939847
91MP0010630_abnormal_cardiac_muscle1.11563842
92MP0002405_respiratory_system_inflammati1.11230785
93MP0005332_abnormal_amino_acid1.11048176
94MP0000609_abnormal_liver_physiology1.10833373
95MP0005083_abnormal_biliary_tract1.10655260
96* MP0002429_abnormal_blood_cell1.08860089
97MP0002722_abnormal_immune_system1.08402772
98MP0003195_calcinosis1.08131728
99MP0009764_decreased_sensitivity_to1.07692998
100MP0005377_hearing/vestibular/ear_phenot1.04330153
101MP0003878_abnormal_ear_physiology1.04330153
102MP0003279_aneurysm1.03960272
103MP0003252_abnormal_bile_duct1.02692852
104MP0002106_abnormal_muscle_physiology1.02309209
105MP0010155_abnormal_intestine_physiology1.01865043
106MP0001905_abnormal_dopamine_level1.00639939
107MP0010094_abnormal_chromosome_stability1.00450156
108MP0001919_abnormal_reproductive_system1.00228764
109MP0005310_abnormal_salivary_gland0.99591182
110MP0003300_gastrointestinal_ulcer0.99478873
111MP0001764_abnormal_homeostasis0.99385294
112MP0002877_abnormal_melanocyte_morpholog0.99180921
113MP0003705_abnormal_hypodermis_morpholog0.98962945
114MP0005167_abnormal_blood-brain_barrier0.98903576
115MP0002006_tumorigenesis0.98034125
116MP0001188_hyperpigmentation0.98012835
117MP0003879_abnormal_hair_cell0.97874862
118MP0002972_abnormal_cardiac_muscle0.97593196
119MP0002332_abnormal_exercise_endurance0.96808102
120MP0000858_altered_metastatic_potential0.96752292
121MP0000598_abnormal_liver_morphology0.94833323
122MP0008775_abnormal_heart_ventricle0.94637108
123MP0005084_abnormal_gallbladder_morpholo0.93702614
124MP0005535_abnormal_body_temperature0.93521153
125MP0000249_abnormal_blood_vessel0.91913682
126MP0005671_abnormal_response_to0.91622462
127MP0005670_abnormal_white_adipose0.91532114
128MP0002118_abnormal_lipid_homeostasis0.91217729
129MP0002971_abnormal_brown_adipose0.90580412
130MP0003566_abnormal_cell_adhesion0.89610662
131MP0003786_premature_aging0.89338341
132MP0009115_abnormal_fat_cell0.88505162
133MP0001958_emphysema0.88194865
134MP0002277_abnormal_respiratory_mucosa0.87255334
135MP0009046_muscle_twitch0.83325445
136MP0004947_skin_inflammation0.81851845
137MP0004742_abnormal_vestibular_system0.81000564
138MP0005645_abnormal_hypothalamus_physiol0.79180989
139MP0005389_reproductive_system_phenotype0.77656063
140MP0001727_abnormal_embryo_implantation0.77202253
141MP0002019_abnormal_tumor_incidence0.77141161
142MP0002163_abnormal_gland_morphology0.74802559
143MP0000313_abnormal_cell_death0.74618636
144MP0000681_abnormal_thyroid_gland0.74402049
145MP0001501_abnormal_sleep_pattern0.74227224
146MP0001502_abnormal_circadian_rhythm0.74056848
147MP0004381_abnormal_hair_follicle0.73042451
148MP0002272_abnormal_nervous_system0.72095817
149MP0000358_abnormal_cell_content/0.71889185
150MP0008874_decreased_physiological_sensi0.70698061
151MP0002210_abnormal_sex_determination0.69979437
152MP0009379_abnormal_foot_pigmentation0.66812804
153MP0003111_abnormal_nucleus_morphology0.66293828

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)3.92596519
2Panhypogammaglobulinemia (HP:0003139)3.77435771
3Asymmetric septal hypertrophy (HP:0001670)3.56271626
4Recurrent abscess formation (HP:0002722)3.38408121
5Abnormality of fatty-acid metabolism (HP:0004359)3.35424586
6Myoglobinuria (HP:0002913)3.32721903
7Combined immunodeficiency (HP:0005387)3.31703455
8Thrombocytosis (HP:0001894)3.30392915
9Agammaglobulinemia (HP:0004432)3.27804050
10Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23047584
11Recurrent bacterial skin infections (HP:0005406)3.11237888
12Myositis (HP:0100614)3.10247843
13Abnormality of liposaccharide metabolism (HP:0010968)3.04391504
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.04391504
15Abnormality of glycolipid metabolism (HP:0010969)3.04391504
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.99051193
17Renal Fanconi syndrome (HP:0001994)2.98887206
18Acute necrotizing encephalopathy (HP:0006965)2.95381189
19Recurrent gram-negative bacterial infections (HP:0005420)2.93314866
20Methylmalonic aciduria (HP:0012120)2.92312689
21Meningitis (HP:0001287)2.91674152
22Obstructive lung disease (HP:0006536)2.90089624
23Chronic obstructive pulmonary disease (HP:0006510)2.90089624
24Recurrent fungal infections (HP:0002841)2.86815690
25Hepatic necrosis (HP:0002605)2.84927230
26B lymphocytopenia (HP:0010976)2.84216119
27Increased muscle lipid content (HP:0009058)2.84208253
28Hypoplasia of the thymus (HP:0000778)2.82756032
29Increased hepatocellular lipid droplets (HP:0006565)2.80453699
30Eczematoid dermatitis (HP:0000976)2.79172651
31Aplasia/Hypoplasia of the thymus (HP:0010515)2.78313728
32Rhabdomyolysis (HP:0003201)2.76925832
33Nausea (HP:0002018)2.76352330
34Abnormality of the nasal mucosa (HP:0000433)2.76057457
35Abnormality of B cell number (HP:0010975)2.72282529
36Elevated erythrocyte sedimentation rate (HP:0003565)2.71352613
37Increased cerebral lipofuscin (HP:0011813)2.70031771
38Nasal polyposis (HP:0100582)2.66487185
39Stomatitis (HP:0010280)2.66185892
40Vacuolated lymphocytes (HP:0001922)2.62433315
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61999378
42Exertional dyspnea (HP:0002875)2.60482320
43Lipid accumulation in hepatocytes (HP:0006561)2.57492801
44Axonal loss (HP:0003447)2.56325038
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.56113215
46Exercise-induced muscle cramps (HP:0003710)2.55619107
47Sudden death (HP:0001699)2.54459615
48Granulocytopenia (HP:0001913)2.54222715
49Ragged-red muscle fibers (HP:0003200)2.52106918
50Hepatocellular necrosis (HP:0001404)2.50650726
51Methylmalonic acidemia (HP:0002912)2.48306940
52Progressive macrocephaly (HP:0004481)2.47300781
53Retrobulbar optic neuritis (HP:0100654)2.43772783
54Optic neuritis (HP:0100653)2.43772783
55Generalized aminoaciduria (HP:0002909)2.43483472
56Respiratory difficulties (HP:0002880)2.42887283
57Hyperammonemia (HP:0001987)2.42300750
58Ventricular tachycardia (HP:0004756)2.41771302
59Prolonged bleeding time (HP:0003010)2.38148458
60IgG deficiency (HP:0004315)2.37587505
61Increased intramyocellular lipid droplets (HP:0012240)2.37274819
62Abnormality of macrophages (HP:0004311)2.37027516
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.36892695
64Recurrent cutaneous fungal infections (HP:0011370)2.36577988
65Chronic mucocutaneous candidiasis (HP:0002728)2.36577988
66Tetany (HP:0001281)2.36330221
67Palpitations (HP:0001962)2.35281038
68Recurrent skin infections (HP:0001581)2.34548872
69Increased serum ferritin (HP:0003281)2.34524878
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.33428711
71Orchitis (HP:0100796)2.33088673
72Hypertensive crisis (HP:0100735)2.31919973
73Lipoatrophy (HP:0100578)2.31411649
74Thyroiditis (HP:0100646)2.30939255
75Petechiae (HP:0000967)2.30003194
76Hypokinesia (HP:0002375)2.29774548
77Abnormality of the left ventricular outflow tract (HP:0011103)2.29746981
78Subaortic stenosis (HP:0001682)2.29746981
79Abnormality of magnesium homeostasis (HP:0004921)2.27035061
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25377391
81Dicarboxylic aciduria (HP:0003215)2.25377391
82Hypomagnesemia (HP:0002917)2.24876186
83Autoimmune thrombocytopenia (HP:0001973)2.24266719
84Neoplasm of head and neck (HP:0012288)2.22695140
85Esophageal neoplasm (HP:0100751)2.22695140
86Abnormality of T cells (HP:0002843)2.21976692
87* Abnormal platelet function (HP:0011869)2.21163915
88* Impaired platelet aggregation (HP:0003540)2.21163915
89Encephalitis (HP:0002383)2.20712403
90Ketosis (HP:0001946)2.19594981
91Recurrent viral infections (HP:0004429)2.13758611
92Systemic lupus erythematosus (HP:0002725)2.13460446
93Exercise intolerance (HP:0003546)2.13104153
94Conjunctival hamartoma (HP:0100780)2.12471979
95Loss of speech (HP:0002371)2.10725145
96Lactic acidosis (HP:0003128)2.10422079
97Abnormality of eosinophils (HP:0001879)2.09252275
98Hyperthyroidism (HP:0000836)2.09048392
99Arterial thrombosis (HP:0004420)2.08991437
100T lymphocytopenia (HP:0005403)2.07484899
101Exercise-induced myalgia (HP:0003738)2.07145978
102Epistaxis (HP:0000421)2.06202128
103IgM deficiency (HP:0002850)2.05496305
104Atrioventricular block (HP:0001678)2.04797354
105Bundle branch block (HP:0011710)2.04632273
106Cellulitis (HP:0100658)2.03853023
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03725924
108Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03725924
109Increased serum lactate (HP:0002151)2.03340274
110Chronic otitis media (HP:0000389)2.02373208
111Abnormality of alanine metabolism (HP:0010916)2.01701243
112Hyperalaninemia (HP:0003348)2.01701243
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01701243
114Atrial fibrillation (HP:0005110)2.01545106
115Abnormality of iron homeostasis (HP:0011031)2.01361357
116Ketoacidosis (HP:0001993)2.00548509
117Multiple enchondromatosis (HP:0005701)1.97863891
118Eosinophilia (HP:0001880)1.97843755
119Supraventricular tachycardia (HP:0004755)1.96918532
120Vasculitis (HP:0002633)1.95591668
121Microretrognathia (HP:0000308)1.94959354
122Mediastinal lymphadenopathy (HP:0100721)1.94855224
123Increased connective tissue (HP:0009025)1.94562738
124Primary atrial arrhythmia (HP:0001692)1.94107312
125Supraventricular arrhythmia (HP:0005115)1.93538775
126Joint hemorrhage (HP:0005261)1.93312164
127Gastrointestinal stroma tumor (HP:0100723)1.93204026
128Leukocytosis (HP:0001974)1.93015872
129Xanthomatosis (HP:0000991)1.92535175
130Progressive muscle weakness (HP:0003323)1.92445368
131Degeneration of anterior horn cells (HP:0002398)1.91232085
132Abnormality of the anterior horn cell (HP:0006802)1.91232085
133Neurodegeneration (HP:0002180)1.90819555
134Dysostosis multiplex (HP:0000943)1.90055240
135Aplastic anemia (HP:0001915)1.89521764
136Skin rash (HP:0000988)1.89395372
137Muscle fiber splitting (HP:0003555)1.88818654
138Increased CSF lactate (HP:0002490)1.87401037
139Abnormality of the thymus (HP:0000777)1.86793452
140Limb-girdle muscle atrophy (HP:0003797)1.86478640
141Vertebral compression fractures (HP:0002953)1.86212469
142Acute hepatic failure (HP:0006554)1.86209616
143Abnormality of T cell number (HP:0011839)1.85505771
144Abnormal number of erythroid precursors (HP:0012131)1.85241255
145Purpura (HP:0000979)1.84988716
146Abnormal gallbladder physiology (HP:0012438)1.84881802
147Cholecystitis (HP:0001082)1.84881802
148Hypertriglyceridemia (HP:0002155)1.84562468
149Menorrhagia (HP:0000132)1.84142451
150Mitochondrial inheritance (HP:0001427)1.83783622
151Acute encephalopathy (HP:0006846)1.83342944
152Urinary glycosaminoglycan excretion (HP:0003541)1.81860609
153Mucopolysacchariduria (HP:0008155)1.81860609
154Sepsis (HP:0100806)1.80878289
155Abnormal mitochondria in muscle tissue (HP:0008316)1.80868822
156Bone cyst (HP:0012062)1.80835267
157Abnormality of DNA repair (HP:0003254)1.80120316
158Abnormality of T cell physiology (HP:0011840)1.79995119
159Increased IgM level (HP:0003496)1.77956105
160Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77954903
161Interstitial pulmonary disease (HP:0006530)1.77629506
162Progressive microcephaly (HP:0000253)1.77560159
163Hypercholesterolemia (HP:0003124)1.77284211
164Lymphopenia (HP:0001888)1.77073161
165Cerebral hypomyelination (HP:0006808)1.76934252
166Hyperglycinuria (HP:0003108)1.76513611
167Urticaria (HP:0001025)1.76317794
168Abnormality of cells of the erythroid lineage (HP:0012130)1.76277653
169Abnormality of glutamine family amino acid metabolism (HP:0010902)1.75824061
170Cerebral edema (HP:0002181)1.75585443
171Thoracic kyphosis (HP:0002942)1.75349613
172Anorexia (HP:0002039)1.75230284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.67699132
2TRIB33.45798914
3TESK23.45770381
4NME22.99406337
5MAP4K12.59899534
6TXK2.57199048
7TTN2.56553453
8MAP3K122.54633544
9VRK22.50798308
10KIT2.42093238
11ERN12.35378755
12RIPK42.32159367
13BCKDK2.29200955
14PIM22.28575487
15TBK12.24989172
16MYLK2.01502107
17MAP2K31.83992189
18MAP3K111.63447219
19BLK1.62060938
20FLT31.61068277
21PDK41.57913852
22PDK31.57913852
23SIK31.57701238
24MARK31.56690141
25TGFBR21.54588421
26BTK1.52077049
27TNK21.50973536
28DAPK11.50588831
29MUSK1.49156776
30SIK21.47991768
31TESK11.45846590
32IRAK31.42548494
33CSF1R1.39173876
34ZAP701.35921301
35SCYL21.35402200
36STK161.35244963
37LMTK21.32838784
38EEF2K1.32560608
39SYK1.32382048
40ILK1.28560699
41KDR1.28024766
42PRKG21.27788577
43NUAK11.22778006
44PINK11.20156679
45LRRK21.17862936
46TEC1.17854115
47TGFBR11.15489692
48TLK11.14478551
49NEK11.10138691
50CAMKK21.07698007
51PAK41.07155797
52TIE11.06792373
53TYK21.06767906
54GRK51.04147215
55PRKCQ1.02871502
56RAF11.01631330
57DAPK31.00398159
58CDK190.99590054
59ABL20.98902317
60IRAK40.98425794
61CAMKK10.95846827
62IKBKE0.94480743
63NEK90.93143730
64RIPK10.92902999
65BUB10.89898786
66BRAF0.89606540
67MAP3K130.87691719
68AURKA0.85452910
69CSK0.83945408
70EIF2AK10.83520463
71JAK30.83368493
72PIM10.82070175
73IKBKB0.80320281
74RPS6KA60.78626540
75MAP3K100.78267696
76ALK0.77270415
77MAP3K30.76968039
78CDK90.76568626
79FES0.75737695
80FGR0.74158425
81TAOK20.71740059
82TAOK30.71568490
83GRK60.71044314
84MAPK40.69585735
85MAP3K140.69474497
86MAP2K20.68249477
87WEE10.68018417
88PTK2B0.67481459
89HCK0.67420736
90ARAF0.66567444
91NTRK30.65935996
92PDK20.64876505
93JAK20.64223087
94PDPK10.63017672
95CSNK1G30.62823494
96MAP4K20.62758563
97SMG10.62657643
98LYN0.61531097
99JAK10.59597020
100MAP3K50.58549080
101MATK0.57663196
102RPS6KC10.57596646
103RPS6KL10.57596646
104NEK20.57066238
105MAPKAPK30.56669203
106DMPK0.56640671
107BRSK10.56371260
108MARK20.56267223
109PDK10.53931734
110VRK10.51461001
111PAK10.50778467
112RPS6KA40.50503269
113KSR20.50004665
114PTK60.49754481
115GRK70.49318481
116LIMK10.49050980
117PRPF4B0.46786519
118TAOK10.46156995
119MAP3K10.45937158
120MAPK110.45267924
121MAP3K70.45117930
122FGFR40.44379107
123STK40.44281540
124TRPM70.43518080
125PRKCI0.42021866
126PIK3CG0.41798418
127MAP3K60.41768887
128LCK0.41175149
129MST1R0.41160489
130BMX0.41156400
131STK240.39084394
132CAMK10.39044740
133DAPK20.38677926
134CSNK1G20.38447884
135PRKCD0.38438639
136NME10.38043822
137STK100.37378907
138HIPK20.36221561
139RPS6KA50.35914149
140MAPK120.35042669
141CSNK2A20.32737491
142ATR0.31413339
143CDK40.30842318
144MAP3K80.30330963
145AKT20.29883780
146MAPK30.29466895
147MST40.26534322

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.80461840
2Primary immunodeficiency_Homo sapiens_hsa053403.31511373
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.20206277
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12419651
5Allograft rejection_Homo sapiens_hsa053302.48253596
6Fatty acid degradation_Homo sapiens_hsa000712.37784230
7Propanoate metabolism_Homo sapiens_hsa006402.31489339
8Autoimmune thyroid disease_Homo sapiens_hsa053202.29237160
9Graft-versus-host disease_Homo sapiens_hsa053322.22954409
10Carbon metabolism_Homo sapiens_hsa012002.20987924
11Ribosome_Homo sapiens_hsa030102.14940519
12Type I diabetes mellitus_Homo sapiens_hsa049402.03480211
13DNA replication_Homo sapiens_hsa030302.00019364
14Parkinsons disease_Homo sapiens_hsa050121.98473695
15Leishmaniasis_Homo sapiens_hsa051401.88408216
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.79876031
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79388127
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79321629
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75020294
20Oxidative phosphorylation_Homo sapiens_hsa001901.63338153
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.60264101
22Sulfur relay system_Homo sapiens_hsa041221.58787063
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55789244
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54926053
25Staphylococcus aureus infection_Homo sapiens_hsa051501.53679930
26Caffeine metabolism_Homo sapiens_hsa002321.52629485
27Pentose phosphate pathway_Homo sapiens_hsa000301.51951495
28PPAR signaling pathway_Homo sapiens_hsa033201.49962727
29Legionellosis_Homo sapiens_hsa051341.48700978
30Biosynthesis of amino acids_Homo sapiens_hsa012301.46651196
31Fatty acid metabolism_Homo sapiens_hsa012121.43541504
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41136887
33Pyruvate metabolism_Homo sapiens_hsa006201.39767772
34Rheumatoid arthritis_Homo sapiens_hsa053231.37610352
35Peroxisome_Homo sapiens_hsa041461.35247726
36Arginine biosynthesis_Homo sapiens_hsa002201.32939099
37B cell receptor signaling pathway_Homo sapiens_hsa046621.31955613
38Osteoclast differentiation_Homo sapiens_hsa043801.31609469
39Alzheimers disease_Homo sapiens_hsa050101.31450729
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31333117
41Homologous recombination_Homo sapiens_hsa034401.31168901
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31047090
43RNA polymerase_Homo sapiens_hsa030201.28907022
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28404480
45Collecting duct acid secretion_Homo sapiens_hsa049661.23333977
46Regulation of autophagy_Homo sapiens_hsa041401.22847177
47Cardiac muscle contraction_Homo sapiens_hsa042601.22824465
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.20309682
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17613721
50Starch and sucrose metabolism_Homo sapiens_hsa005001.16431217
51Galactose metabolism_Homo sapiens_hsa000521.12534229
52Lysosome_Homo sapiens_hsa041421.06953064
53Epstein-Barr virus infection_Homo sapiens_hsa051691.05231798
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04523047
55Tuberculosis_Homo sapiens_hsa051521.02985166
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01961431
57Nucleotide excision repair_Homo sapiens_hsa034201.00979273
58Base excision repair_Homo sapiens_hsa034100.99942220
59Tryptophan metabolism_Homo sapiens_hsa003800.98165970
60Synaptic vesicle cycle_Homo sapiens_hsa047210.98104324
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96387750
62Pertussis_Homo sapiens_hsa051330.95020892
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.92901867
64Huntingtons disease_Homo sapiens_hsa050160.92881082
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88809340
66Complement and coagulation cascades_Homo sapiens_hsa046100.88016430
67Acute myeloid leukemia_Homo sapiens_hsa052210.87713057
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87367002
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84563106
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84194854
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84074108
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.83432447
73beta-Alanine metabolism_Homo sapiens_hsa004100.81398553
74Asthma_Homo sapiens_hsa053100.81185057
75Spliceosome_Homo sapiens_hsa030400.80515435
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79850783
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.79766101
78Other glycan degradation_Homo sapiens_hsa005110.79486084
79Fructose and mannose metabolism_Homo sapiens_hsa000510.79148443
80RNA degradation_Homo sapiens_hsa030180.78334984
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78171085
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77130407
83Platelet activation_Homo sapiens_hsa046110.76484174
84Protein export_Homo sapiens_hsa030600.74129796
85Shigellosis_Homo sapiens_hsa051310.73588409
86HIF-1 signaling pathway_Homo sapiens_hsa040660.73115364
87Chemokine signaling pathway_Homo sapiens_hsa040620.72894171
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69542935
89Malaria_Homo sapiens_hsa051440.69404902
90Salmonella infection_Homo sapiens_hsa051320.69320329
91African trypanosomiasis_Homo sapiens_hsa051430.69222919
92Non-homologous end-joining_Homo sapiens_hsa034500.68990427
93Fatty acid elongation_Homo sapiens_hsa000620.68792379
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67851539
95T cell receptor signaling pathway_Homo sapiens_hsa046600.67678519
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67433539
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65749105
98Apoptosis_Homo sapiens_hsa042100.64574248
99One carbon pool by folate_Homo sapiens_hsa006700.64005946
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.63780204
101Pyrimidine metabolism_Homo sapiens_hsa002400.63626353
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63343102
103Insulin resistance_Homo sapiens_hsa049310.62550551
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61317219
105Toxoplasmosis_Homo sapiens_hsa051450.61170935
106Proteasome_Homo sapiens_hsa030500.61042140
107Insulin signaling pathway_Homo sapiens_hsa049100.60648483
108Folate biosynthesis_Homo sapiens_hsa007900.60380998
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60283110
110Vibrio cholerae infection_Homo sapiens_hsa051100.59985719
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.56819948
112Measles_Homo sapiens_hsa051620.56384633
113Purine metabolism_Homo sapiens_hsa002300.56286420
114Antigen processing and presentation_Homo sapiens_hsa046120.55994885
115Fanconi anemia pathway_Homo sapiens_hsa034600.55470570
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55183620
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54845778
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54716401
119Phagosome_Homo sapiens_hsa041450.52708138
120Hepatitis C_Homo sapiens_hsa051600.52626201
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.51875506
122Viral myocarditis_Homo sapiens_hsa054160.51159054
123VEGF signaling pathway_Homo sapiens_hsa043700.48897393
124Oocyte meiosis_Homo sapiens_hsa041140.47990581
125Butanoate metabolism_Homo sapiens_hsa006500.47822936
126Sulfur metabolism_Homo sapiens_hsa009200.47112557
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46651746
128Mismatch repair_Homo sapiens_hsa034300.45840615
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.45512620
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44025005
131Glucagon signaling pathway_Homo sapiens_hsa049220.43873331
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43758267
133Hematopoietic cell lineage_Homo sapiens_hsa046400.43278518
134Dilated cardiomyopathy_Homo sapiens_hsa054140.41146474
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.41139038
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40375631
137RNA transport_Homo sapiens_hsa030130.39255028
138TNF signaling pathway_Homo sapiens_hsa046680.39036553
139Hepatitis B_Homo sapiens_hsa051610.37700123
140Long-term potentiation_Homo sapiens_hsa047200.35336963
141Herpes simplex infection_Homo sapiens_hsa051680.34355597
142Influenza A_Homo sapiens_hsa051640.33693383
143Endocytosis_Homo sapiens_hsa041440.33338010

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