DTWD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.61479471
2ribosomal small subunit assembly (GO:0000028)4.33610828
3telomere maintenance via semi-conservative replication (GO:0032201)4.04813705
4DNA replication initiation (GO:0006270)3.98360683
5rRNA modification (GO:0000154)3.90221432
6piRNA metabolic process (GO:0034587)3.89539078
7regulation of nuclear cell cycle DNA replication (GO:0033262)3.84278367
8pseudouridine synthesis (GO:0001522)3.76226028
9cellular ketone body metabolic process (GO:0046950)3.75398592
10kynurenine metabolic process (GO:0070189)3.74914981
11rRNA methylation (GO:0031167)3.74720810
12kinetochore assembly (GO:0051382)3.72157815
13DNA strand elongation involved in DNA replication (GO:0006271)3.67629673
14ubiquinone biosynthetic process (GO:0006744)3.65083785
15kinetochore organization (GO:0051383)3.64848472
16DNA deamination (GO:0045006)3.64732340
17regulation of hippo signaling (GO:0035330)3.60847176
18DNA strand elongation (GO:0022616)3.60416168
19telomere maintenance via recombination (GO:0000722)3.57183124
20DNA replication checkpoint (GO:0000076)3.57049807
21response to pheromone (GO:0019236)3.53534633
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.52215971
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.49295255
24replication fork processing (GO:0031297)3.48202358
25telomere maintenance via telomere lengthening (GO:0010833)3.47449370
26CENP-A containing nucleosome assembly (GO:0034080)3.45533330
27ribosome biogenesis (GO:0042254)3.45171905
28ketone body metabolic process (GO:1902224)3.40999837
29ubiquinone metabolic process (GO:0006743)3.39099250
30proteasome assembly (GO:0043248)3.37125431
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.36485276
32termination of RNA polymerase III transcription (GO:0006386)3.36485276
33tryptophan catabolic process (GO:0006569)3.35794140
34indole-containing compound catabolic process (GO:0042436)3.35794140
35indolalkylamine catabolic process (GO:0046218)3.35794140
36positive regulation of prostaglandin secretion (GO:0032308)3.34205317
37water-soluble vitamin biosynthetic process (GO:0042364)3.30647182
38chromatin remodeling at centromere (GO:0031055)3.30579319
39mitotic recombination (GO:0006312)3.30573086
40viral mRNA export from host cell nucleus (GO:0046784)3.26420395
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.26048063
42tryptophan metabolic process (GO:0006568)3.25832702
43maturation of SSU-rRNA (GO:0030490)3.25742640
44regulation of helicase activity (GO:0051095)3.24978857
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.22815022
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22815022
47ribonucleoprotein complex biogenesis (GO:0022613)3.22664027
48IMP biosynthetic process (GO:0006188)3.21308885
49preassembly of GPI anchor in ER membrane (GO:0016254)3.20938405
50tRNA methylation (GO:0030488)3.15819585
51detection of light stimulus involved in visual perception (GO:0050908)3.15808529
52detection of light stimulus involved in sensory perception (GO:0050962)3.15808529
53mitotic cell cycle arrest (GO:0071850)3.15069356
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14740670
55nucleobase biosynthetic process (GO:0046112)3.14274285
56meiotic chromosome segregation (GO:0045132)3.11490549
57purine nucleobase biosynthetic process (GO:0009113)3.11147409
58indolalkylamine metabolic process (GO:0006586)3.09474428
59regulation of mesoderm development (GO:2000380)3.08755902
60cullin deneddylation (GO:0010388)3.07165209
61sulfation (GO:0051923)3.06345295
62protein-cofactor linkage (GO:0018065)3.05511421
63magnesium ion transport (GO:0015693)3.03576140
64gamma-aminobutyric acid transport (GO:0015812)3.03537894
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.01235694
66termination of RNA polymerase I transcription (GO:0006363)3.00829930
67ribosomal small subunit biogenesis (GO:0042274)3.00820221
68fatty acid transmembrane transport (GO:1902001)3.00674875
69transcription elongation from RNA polymerase I promoter (GO:0006362)2.98640308
70IMP metabolic process (GO:0046040)2.98467425
71DNA methylation involved in gamete generation (GO:0043046)2.97315152
72protein deneddylation (GO:0000338)2.96842699
73ribosomal large subunit biogenesis (GO:0042273)2.95895699
74rRNA processing (GO:0006364)2.95204056
75respiratory chain complex IV assembly (GO:0008535)2.95134494
76regulation of gene silencing by miRNA (GO:0060964)2.93653661
77regulation of gene silencing by RNA (GO:0060966)2.93653661
78regulation of posttranscriptional gene silencing (GO:0060147)2.93653661
79DNA synthesis involved in DNA repair (GO:0000731)2.93322966
80transcription-coupled nucleotide-excision repair (GO:0006283)2.92657731
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92019601
82mismatch repair (GO:0006298)2.91373716
83reciprocal DNA recombination (GO:0035825)2.90406568
84reciprocal meiotic recombination (GO:0007131)2.90406568
85rRNA metabolic process (GO:0016072)2.89604333
86transcription from RNA polymerase I promoter (GO:0006360)2.89555631
87DNA replication-independent nucleosome assembly (GO:0006336)2.89532544
88DNA replication-independent nucleosome organization (GO:0034724)2.89532544
89mitotic metaphase plate congression (GO:0007080)2.89236619
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89098695
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89098695
92protein K6-linked ubiquitination (GO:0085020)2.86131336
93intra-S DNA damage checkpoint (GO:0031573)2.85963097
94RNA-dependent DNA replication (GO:0006278)2.85461888
95S-adenosylmethionine metabolic process (GO:0046500)2.83671836
96rRNA catabolic process (GO:0016075)2.83165815
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83087335
98telomere maintenance (GO:0000723)2.82562686
99lysine catabolic process (GO:0006554)2.82412631
100lysine metabolic process (GO:0006553)2.82412631
101maturation of 5.8S rRNA (GO:0000460)2.81911443
102kidney morphogenesis (GO:0060993)2.80885797
103telomere organization (GO:0032200)2.80800894
104telomere maintenance via telomerase (GO:0007004)2.80736515
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80704145
106negative regulation of DNA-dependent DNA replication (GO:2000104)2.78935753
107positive regulation of fatty acid transport (GO:2000193)2.78399298
108quinone biosynthetic process (GO:1901663)2.78308916
109branched-chain amino acid catabolic process (GO:0009083)2.77884298
110positive regulation of DNA-dependent DNA replication (GO:2000105)2.76989101
111regulation of memory T cell differentiation (GO:0043380)2.75560856
112regulation of mitotic spindle checkpoint (GO:1903504)2.75181223
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75181223
114synapsis (GO:0007129)2.74891462
115RNA methylation (GO:0001510)2.74770030
116platelet dense granule organization (GO:0060155)2.74703331
117somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74409645
118isotype switching (GO:0045190)2.74409645
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74409645
120peptidyl-threonine dephosphorylation (GO:0035970)2.73799019
121L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72196960
122multicellular organism reproduction (GO:0032504)2.72067985
123aspartate family amino acid catabolic process (GO:0009068)2.70948431
124transcription initiation from RNA polymerase I promoter (GO:0006361)2.69860024
125regulation of hexokinase activity (GO:1903299)2.69699632
126regulation of glucokinase activity (GO:0033131)2.69699632
127methionine biosynthetic process (GO:0009086)2.69456248
128deoxyribonucleotide biosynthetic process (GO:0009263)2.69027196
129mitochondrial RNA metabolic process (GO:0000959)2.68485287
130negative regulation of telomere maintenance (GO:0032205)2.68253141
131cellular component biogenesis (GO:0044085)2.65934226
132DNA-dependent DNA replication (GO:0006261)2.65343622
133protein K11-linked deubiquitination (GO:0035871)2.64875956
134attachment of spindle microtubules to kinetochore (GO:0008608)2.64754146
135amino acid salvage (GO:0043102)2.63664385
136L-methionine salvage (GO:0071267)2.63664385
137L-methionine biosynthetic process (GO:0071265)2.63664385
138DNA double-strand break processing (GO:0000729)2.63348108
139deoxyribose phosphate biosynthetic process (GO:0046385)2.63270547
1402-deoxyribonucleotide biosynthetic process (GO:0009265)2.63270547
141formation of translation preinitiation complex (GO:0001731)2.62393452
142negative regulation of reactive oxygen species metabolic process (GO:2000378)2.62024382
143neural tube formation (GO:0001841)2.61036986
144energy homeostasis (GO:0097009)2.60884768
145recombinational repair (GO:0000725)2.60831877
146spliceosomal snRNP assembly (GO:0000387)2.60756671
1477-methylguanosine mRNA capping (GO:0006370)2.60342387
148reflex (GO:0060004)2.60306513
149histone exchange (GO:0043486)2.60154331
150DNA ligation (GO:0006266)2.59957582
151double-strand break repair via homologous recombination (GO:0000724)2.59733984
152positive regulation of icosanoid secretion (GO:0032305)2.59429366
153rhodopsin mediated signaling pathway (GO:0016056)2.59136395
154regulation of action potential (GO:0098900)2.59045015
155RNA capping (GO:0036260)2.58778496
1567-methylguanosine RNA capping (GO:0009452)2.58778496
157regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57738599
158adenosine metabolic process (GO:0046085)2.57348151
159DNA replication (GO:0006260)2.56876815
160daunorubicin metabolic process (GO:0044597)2.56795925
161polyketide metabolic process (GO:0030638)2.56795925
162doxorubicin metabolic process (GO:0044598)2.56795925
163negative regulation by host of viral transcription (GO:0043922)2.56405568
164interkinetic nuclear migration (GO:0022027)2.55018360
165regulation of prostaglandin secretion (GO:0032306)2.54735320
166regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54346121
167ncRNA processing (GO:0034470)2.54336316
168dopamine transport (GO:0015872)2.54172910
169tRNA processing (GO:0008033)2.54053146
170regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.53863490
171fucose catabolic process (GO:0019317)2.52592431
172L-fucose metabolic process (GO:0042354)2.52592431
173L-fucose catabolic process (GO:0042355)2.52592431
174tRNA modification (GO:0006400)2.52211165
175DNA catabolic process, exonucleolytic (GO:0000738)2.48992119
176nuclear pore organization (GO:0006999)2.47282105
177cytochrome complex assembly (GO:0017004)2.46813983
178epithelial cilium movement (GO:0003351)2.46443804
179gene silencing by RNA (GO:0031047)2.46150875
180somatic diversification of immunoglobulins (GO:0016445)2.45388884
181male meiosis (GO:0007140)2.44258189
182cAMP catabolic process (GO:0006198)2.44070146
183somite rostral/caudal axis specification (GO:0032525)2.43995715
184nephron epithelium morphogenesis (GO:0072088)2.43222067
185nephron tubule morphogenesis (GO:0072078)2.43222067
186methionine metabolic process (GO:0006555)2.42720561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.89503686
2ZNF274_21170338_ChIP-Seq_K562_Hela3.89825924
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.76133119
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65424676
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57711464
6VDR_22108803_ChIP-Seq_LS180_Human3.49189915
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.13550027
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.08332994
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00640160
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.99562711
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97858114
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.67212752
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66108987
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59142818
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57259319
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49567449
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47742268
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45052952
19GBX2_23144817_ChIP-Seq_PC3_Human2.44076713
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38109433
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.38008678
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37210898
23VDR_23849224_ChIP-Seq_CD4+_Human2.36678586
24* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33818718
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32920122
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31566098
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31301187
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29209398
29FUS_26573619_Chip-Seq_HEK293_Human2.25596477
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23251144
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18449892
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16032463
33TAF15_26573619_Chip-Seq_HEK293_Human2.15806065
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.14560310
35FOXP3_21729870_ChIP-Seq_TREG_Human2.12852772
36NOTCH1_21737748_ChIP-Seq_TLL_Human2.11943448
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10955428
38FOXM1_23109430_ChIP-Seq_U2OS_Human2.07526698
39ELK1_19687146_ChIP-ChIP_HELA_Human2.05667694
40ER_23166858_ChIP-Seq_MCF-7_Human2.04829240
41* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02593699
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.98680859
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95756613
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95382701
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93199066
46* P300_19829295_ChIP-Seq_ESCs_Human1.92870305
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87559743
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.85232821
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83454236
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81427245
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78961537
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.74794373
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74594731
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73015197
55EZH2_22144423_ChIP-Seq_EOC_Human1.72021498
56* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71342337
57IRF1_19129219_ChIP-ChIP_H3396_Human1.70260458
58DCP1A_22483619_ChIP-Seq_HELA_Human1.69923842
59XRN2_22483619_ChIP-Seq_HELA_Human1.69300574
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66125121
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65692405
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64407600
63BCAT_22108803_ChIP-Seq_LS180_Human1.64294339
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63522715
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62523849
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.61896426
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61065497
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60963465
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60884594
70* STAT3_23295773_ChIP-Seq_U87_Human1.60029420
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60027444
72CBP_20019798_ChIP-Seq_JUKART_Human1.57832102
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57832102
74TTF2_22483619_ChIP-Seq_HELA_Human1.57690750
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55203661
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54781723
77TCF4_23295773_ChIP-Seq_U87_Human1.53980292
78TP53_22573176_ChIP-Seq_HFKS_Human1.50955966
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49475458
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49458034
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49450800
82AR_21909140_ChIP-Seq_LNCAP_Human1.49214222
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47014706
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46558290
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45506255
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44562942
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.44144267
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44057986
89SOX2_19829295_ChIP-Seq_ESCs_Human1.42763274
90NANOG_19829295_ChIP-Seq_ESCs_Human1.42763274
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42400681
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.41454372
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40987533
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.40987533
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40369524
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39678026
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37087748
98GABP_19822575_ChIP-Seq_HepG2_Human1.36673967
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35476781
100* SMAD4_21799915_ChIP-Seq_A2780_Human1.35070924
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33378410
102CIITA_25753668_ChIP-Seq_RAJI_Human1.31389983
103AR_25329375_ChIP-Seq_VCAP_Human1.31154248
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29557231
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29388573
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29360002
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.29130310
108TCF4_22108803_ChIP-Seq_LS180_Human1.28145668
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27186699
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26326304
111MYC_18940864_ChIP-ChIP_HL60_Human1.26042807
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25831833
113FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25772133
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25237881
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25237881
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25237881
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.22950418
118AR_20517297_ChIP-Seq_VCAP_Human1.22895923
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22706339
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21994503
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21618186
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21255978
123* RUNX2_22187159_ChIP-Seq_PCA_Human1.20838324
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.20441073
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19848047
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19848047
127HOXB7_26014856_ChIP-Seq_BT474_Human1.19148759
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17990976
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17987388
130* SMAD3_21741376_ChIP-Seq_EPCs_Human1.17967595
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.17885837
132EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17107116
133PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16397622
134PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16300530
135* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15682986
136CDX2_22108803_ChIP-Seq_LS180_Human1.14070831
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13230378
138* GATA3_21878914_ChIP-Seq_MCF-7_Human1.12845919
139SCL_19346495_ChIP-Seq_HPC-7_Human1.11593645
140AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11281809
141IGF1R_20145208_ChIP-Seq_DFB_Human1.11118409
142* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10611121
143* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09175200
144EGR1_19374776_ChIP-ChIP_THP-1_Human1.08800024
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07336829
146NCOR_22424771_ChIP-Seq_293T_Human1.06830522
147SPI1_23547873_ChIP-Seq_NB4_Human1.04083322
148HTT_18923047_ChIP-ChIP_STHdh_Human1.02509070
149POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02032882
150IRF8_22096565_ChIP-ChIP_GC-B_Human1.01625912
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00635198
152STAT3_18555785_Chip-Seq_ESCs_Mouse1.00456937
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00022448
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.99644557
155STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98585617
156* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98569245
157RNF2_27304074_Chip-Seq_NSC_Mouse0.98503450
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98411718
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98238743
160P53_22387025_ChIP-Seq_ESCs_Mouse0.97794897
161FOXH1_21741376_ChIP-Seq_EPCs_Human0.97672009
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96660559
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.96540226
164NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94818723
165IRF8_21731497_ChIP-ChIP_J774_Mouse0.92094063
166KDM5A_27292631_Chip-Seq_BREAST_Human0.90284332
167TFEB_21752829_ChIP-Seq_HELA_Human0.85496875
168KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85227093
169E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84680632
170* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84663489
171SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80601840
172* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80085334
173EWS_26573619_Chip-Seq_HEK293_Human0.78836844
174CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78166745
175TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77551447
176NFE2_27457419_Chip-Seq_LIVER_Mouse0.76089863
177CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76067858
178* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75958259
179MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.71963934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.79018094
2MP0000569_abnormal_digit_pigmentation3.76502429
3MP0003195_calcinosis3.69198089
4MP0003646_muscle_fatigue3.63631103
5MP0008058_abnormal_DNA_repair3.54104893
6MP0008057_abnormal_DNA_replication3.52484190
7MP0006292_abnormal_olfactory_placode3.37773013
8MP0003111_abnormal_nucleus_morphology3.12674416
9MP0003693_abnormal_embryo_hatching3.03563014
10MP0004145_abnormal_muscle_electrophysio2.69677709
11MP0008007_abnormal_cellular_replicative2.67776112
12MP0002837_dystrophic_cardiac_calcinosis2.62968343
13MP0002102_abnormal_ear_morphology2.56009974
14MP0003077_abnormal_cell_cycle2.48230552
15MP0003136_yellow_coat_color2.46961004
16MP0003786_premature_aging2.45857013
17MP0004957_abnormal_blastocyst_morpholog2.43610590
18MP0002396_abnormal_hematopoietic_system2.39218237
19MP0005551_abnormal_eye_electrophysiolog2.36940699
20MP0001188_hyperpigmentation2.31480837
21MP0002132_abnormal_respiratory_system2.31051934
22MP0005075_abnormal_melanosome_morpholog2.24637075
23MP0008789_abnormal_olfactory_epithelium2.13539855
24MP0006072_abnormal_retinal_apoptosis2.04694514
25MP0004043_abnormal_pH_regulation2.02859115
26MP0004885_abnormal_endolymph2.01657642
27MP0003941_abnormal_skin_development1.98206636
28MP0005084_abnormal_gallbladder_morpholo1.96675549
29MP0008872_abnormal_physiological_respon1.95925746
30MP0005645_abnormal_hypothalamus_physiol1.90022013
31MP0008877_abnormal_DNA_methylation1.88746390
32MP0000015_abnormal_ear_pigmentation1.84771891
33MP0004215_abnormal_myocardial_fiber1.76605239
34MP0009697_abnormal_copulation1.76433968
35MP0002138_abnormal_hepatobiliary_system1.75935032
36MP0000490_abnormal_crypts_of1.74079251
37MP0008875_abnormal_xenobiotic_pharmacok1.73744575
38MP0004782_abnormal_surfactant_physiolog1.71459286
39MP0000427_abnormal_hair_cycle1.71434604
40MP0003763_abnormal_thymus_physiology1.70781994
41MP0002009_preneoplasia1.70221127
42MP0001986_abnormal_taste_sensitivity1.66487491
43MP0000383_abnormal_hair_follicle1.66432332
44MP0005253_abnormal_eye_physiology1.65402655
45MP0000566_synostosis1.65259422
46MP0005499_abnormal_olfactory_system1.63997978
47MP0005394_taste/olfaction_phenotype1.63997978
48MP0002876_abnormal_thyroid_physiology1.58607489
49MP0005646_abnormal_pituitary_gland1.52619894
50MP0002095_abnormal_skin_pigmentation1.51924820
51MP0008775_abnormal_heart_ventricle1.50849247
52MP0009046_muscle_twitch1.49755553
53MP0001968_abnormal_touch/_nociception1.49637906
54MP0001835_abnormal_antigen_presentation1.49173230
55MP0009785_altered_susceptibility_to1.48843402
56MP0005187_abnormal_penis_morphology1.46515252
57MP0008932_abnormal_embryonic_tissue1.43721346
58MP0001545_abnormal_hematopoietic_system1.41304414
59MP0005397_hematopoietic_system_phenotyp1.41304414
60MP0002277_abnormal_respiratory_mucosa1.39242184
61MP0004142_abnormal_muscle_tone1.39145495
62MP0001485_abnormal_pinna_reflex1.37664024
63MP0004084_abnormal_cardiac_muscle1.37371937
64MP0005171_absent_coat_pigmentation1.35257792
65MP0003718_maternal_effect1.33599920
66MP0005671_abnormal_response_to1.32909058
67MP0005085_abnormal_gallbladder_physiolo1.30328902
68MP0009333_abnormal_splenocyte_physiolog1.29241064
69MP0003252_abnormal_bile_duct1.29236016
70MP0004808_abnormal_hematopoietic_stem1.27757400
71MP0002736_abnormal_nociception_after1.27572851
72MP0008995_early_reproductive_senescence1.27541466
73MP0005409_darkened_coat_color1.27380869
74MP0008260_abnormal_autophagy1.27327086
75MP0000350_abnormal_cell_proliferation1.27238075
76MP0002210_abnormal_sex_determination1.26147296
77MP0000372_irregular_coat_pigmentation1.25957661
78MP0001119_abnormal_female_reproductive1.24139304
79MP0010307_abnormal_tumor_latency1.24121379
80MP0002160_abnormal_reproductive_system1.23894766
81MP0002398_abnormal_bone_marrow1.22434960
82MP0005332_abnormal_amino_acid1.21409468
83MP0003186_abnormal_redox_activity1.21182774
84MP0003943_abnormal_hepatobiliary_system1.19375268
85MP0005174_abnormal_tail_pigmentation1.19325078
86MP0002148_abnormal_hypersensitivity_rea1.18619650
87MP0000631_abnormal_neuroendocrine_gland1.17403429
88MP0009745_abnormal_behavioral_response1.16602200
89MP0001984_abnormal_olfaction1.16390880
90MP0001186_pigmentation_phenotype1.15382955
91MP0004130_abnormal_muscle_cell1.15368879
92MP0010678_abnormal_skin_adnexa1.15011001
93MP0000313_abnormal_cell_death1.14151988
94MP0004381_abnormal_hair_follicle1.14057858
95MP0005083_abnormal_biliary_tract1.12161753
96MP0005389_reproductive_system_phenotype1.08697112
97MP0004133_heterotaxia1.08643076
98MP0002928_abnormal_bile_duct1.08077742
99MP0000689_abnormal_spleen_morphology1.08001724
100MP0000230_abnormal_systemic_arterial1.06307154
101MP0002234_abnormal_pharynx_morphology1.05506887
102MP0001501_abnormal_sleep_pattern1.05494426
103MP0005410_abnormal_fertilization1.04473828
104MP0002019_abnormal_tumor_incidence1.03863203
105MP0002163_abnormal_gland_morphology1.02814453
106MP0002722_abnormal_immune_system1.02663825
107MP0005167_abnormal_blood-brain_barrier1.02619216
108MP0003890_abnormal_embryonic-extraembry1.02320927
109MP0005365_abnormal_bile_salt1.01997406
110MP0002075_abnormal_coat/hair_pigmentati1.01627555
111MP0001919_abnormal_reproductive_system1.00360277
112MP0004147_increased_porphyrin_level0.98575002
113MP0000703_abnormal_thymus_morphology0.96879302
114MP0001145_abnormal_male_reproductive0.96460321
115MP0004742_abnormal_vestibular_system0.96036138
116MP0002420_abnormal_adaptive_immunity0.95525233
117MP0003950_abnormal_plasma_membrane0.95404690
118MP0000653_abnormal_sex_gland0.95377825
119MP0004036_abnormal_muscle_relaxation0.95337964
120MP0005379_endocrine/exocrine_gland_phen0.93573305
121MP0004484_altered_response_of0.93078153
122MP0006036_abnormal_mitochondrial_physio0.92632096
123MP0010030_abnormal_orbit_morphology0.92485110
124MP0002429_abnormal_blood_cell0.91988136
125MP0000858_altered_metastatic_potential0.91909120
126MP0001819_abnormal_immune_cell0.91621384
127MP0002272_abnormal_nervous_system0.91579803
128MP0009379_abnormal_foot_pigmentation0.89871569
129MP0000716_abnormal_immune_system0.89801048
130MP0000465_gastrointestinal_hemorrhage0.89775617
131MP0000681_abnormal_thyroid_gland0.89130853
132MP0000678_abnormal_parathyroid_gland0.88745793
133MP0005620_abnormal_muscle_contractility0.88580719
134MP0000013_abnormal_adipose_tissue0.86954173
135MP0002653_abnormal_ependyma_morphology0.86734826
136MP0001929_abnormal_gametogenesis0.86145030
137MP0006035_abnormal_mitochondrial_morpho0.86055220
138MP0001800_abnormal_humoral_immune0.86028574
139MP0003137_abnormal_impulse_conducting0.84895726
140MP0002938_white_spotting0.84313035
141MP0002452_abnormal_antigen_presenting0.83600770
142MP0002723_abnormal_immune_serum0.82985242
143MP0003937_abnormal_limbs/digits/tail_de0.81500413
144MP0003806_abnormal_nucleotide_metabolis0.80989532
145MP0002254_reproductive_system_inflammat0.80397942
146MP0000516_abnormal_urinary_system0.79770640
147MP0005367_renal/urinary_system_phenotyp0.79770640
148MP0003119_abnormal_digestive_system0.79706638
149MP0005025_abnormal_response_to0.79226150
150MP0002638_abnormal_pupillary_reflex0.78683766
151MP0001764_abnormal_homeostasis0.78583267
152MP0002067_abnormal_sensory_capabilities0.77738205
153MP0002405_respiratory_system_inflammati0.77556331
154MP0005386_behavior/neurological_phenoty0.77504624
155MP0004924_abnormal_behavior0.77504624
156MP0003787_abnormal_imprinting0.77096656
157MP0003121_genomic_imprinting0.77051868
158MP0003698_abnormal_male_reproductive0.76713891
159MP0006276_abnormal_autonomic_nervous0.76319258
160MP0000049_abnormal_middle_ear0.76205364
161MP0005266_abnormal_metabolism0.76144172
162MP0005195_abnormal_posterior_eye0.75767095
163MP0000647_abnormal_sebaceous_gland0.75401399
164MP0000749_muscle_degeneration0.74088061
165MP0005000_abnormal_immune_tolerance0.74005982
166MP0001324_abnormal_eye_pigmentation0.73638588
167MP0001661_extended_life_span0.72696497
168MP0005647_abnormal_sex_gland0.72618037
169MP0009765_abnormal_xenobiotic_induced0.72482084
170MP0001293_anophthalmia0.70260889
171MP0001672_abnormal_embryogenesis/_devel0.70091092
172MP0005380_embryogenesis_phenotype0.70091092
173MP0002229_neurodegeneration0.69033923
174MP0003183_abnormal_peptide_metabolism0.68605850
175MP0000371_diluted_coat_color0.68200264
176MP0010329_abnormal_lipoprotein_level0.67645722

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.94714624
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.89741436
3Molar tooth sign on MRI (HP:0002419)3.74234254
4Abnormality of midbrain morphology (HP:0002418)3.74234254
5Abnormality of the renal cortex (HP:0011035)3.59808400
6Birth length less than 3rd percentile (HP:0003561)3.54418460
7Hyperventilation (HP:0002883)3.52526285
8Congenital stationary night blindness (HP:0007642)3.39128234
9Abnormality of the preputium (HP:0100587)3.37623641
10Type I transferrin isoform profile (HP:0003642)3.35930225
11Nephronophthisis (HP:0000090)3.33699043
12Type II lissencephaly (HP:0007260)3.30522943
13Meckel diverticulum (HP:0002245)3.30260572
14Attenuation of retinal blood vessels (HP:0007843)3.30084516
15Absent thumb (HP:0009777)3.28883516
16Aplastic anemia (HP:0001915)3.27976590
17Reticulocytopenia (HP:0001896)3.27924711
18Tubular atrophy (HP:0000092)3.19579280
19Abnormality of the ileum (HP:0001549)3.18386564
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.14677642
21Abnormality of the renal medulla (HP:0100957)3.12212551
22Abnormality of chromosome stability (HP:0003220)3.04948197
23Reduced antithrombin III activity (HP:0001976)3.03072104
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02863605
25Abnormality of alanine metabolism (HP:0010916)3.02863605
26Hyperalaninemia (HP:0003348)3.02863605
27Large for gestational age (HP:0001520)2.94717377
28Abolished electroretinogram (ERG) (HP:0000550)2.92412519
29Clubbing of toes (HP:0100760)2.89696391
30Fair hair (HP:0002286)2.85468758
31Microvesicular hepatic steatosis (HP:0001414)2.85155577
32Abnormal drinking behavior (HP:0030082)2.79133269
33Polydipsia (HP:0001959)2.79133269
34Gaze-evoked nystagmus (HP:0000640)2.75033282
35Myelodysplasia (HP:0002863)2.69362314
36Septo-optic dysplasia (HP:0100842)2.66845719
37Inability to walk (HP:0002540)2.65286538
38Abnormality of the renal collecting system (HP:0004742)2.64854569
39Medial flaring of the eyebrow (HP:0010747)2.63755826
40Prostate neoplasm (HP:0100787)2.61471509
41Breast hypoplasia (HP:0003187)2.60472138
42Type 2 muscle fiber atrophy (HP:0003554)2.55851458
43Duplicated collecting system (HP:0000081)2.52198887
44Bone marrow hypocellularity (HP:0005528)2.50791685
45Stomach cancer (HP:0012126)2.50526508
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.50217958
47Duodenal stenosis (HP:0100867)2.48934978
48Small intestinal stenosis (HP:0012848)2.48934978
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.48436391
50Abnormal lung lobation (HP:0002101)2.47079992
51Broad-based gait (HP:0002136)2.45022664
52Polyuria (HP:0000103)2.42563641
53Chronic hepatic failure (HP:0100626)2.41072311
54Clumsiness (HP:0002312)2.40609934
55Cerebellar dysplasia (HP:0007033)2.35741207
56Muscle hypertrophy of the lower extremities (HP:0008968)2.35370301
57Impulsivity (HP:0100710)2.33148799
58Progressive inability to walk (HP:0002505)2.32823675
59Abnormality of the pons (HP:0007361)2.32386553
60Sparse eyelashes (HP:0000653)2.30393683
61Abnormal number of erythroid precursors (HP:0012131)2.29223006
62Hyperglycinuria (HP:0003108)2.27417787
63Patellar aplasia (HP:0006443)2.26971229
64Calf muscle hypertrophy (HP:0008981)2.26885318
65Lissencephaly (HP:0001339)2.26503902
66Concave nail (HP:0001598)2.25063235
67Abnormality of cells of the erythroid lineage (HP:0012130)2.24103181
68Pendular nystagmus (HP:0012043)2.23843679
69Congenital, generalized hypertrichosis (HP:0004540)2.23141631
7011 pairs of ribs (HP:0000878)2.22052764
71Triphalangeal thumb (HP:0001199)2.21290488
72Cystic liver disease (HP:0006706)2.20038937
73Asplenia (HP:0001746)2.19432230
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19070225
75Abnormal protein N-linked glycosylation (HP:0012347)2.19070225
76Abnormal protein glycosylation (HP:0012346)2.19070225
77Abnormal glycosylation (HP:0012345)2.19070225
78Degeneration of anterior horn cells (HP:0002398)2.17638718
79Abnormality of the anterior horn cell (HP:0006802)2.17638718
80Tinnitus (HP:0000360)2.16900534
81Ectopic kidney (HP:0000086)2.14216049
82Abnormality of the prostate (HP:0008775)2.13997582
83Hypomagnesemia (HP:0002917)2.13013160
84Aplasia/Hypoplasia of the patella (HP:0006498)2.13002838
85Muscle fiber atrophy (HP:0100295)2.12616285
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.12181232
87Sclerocornea (HP:0000647)2.11994679
883-Methylglutaconic aciduria (HP:0003535)2.11269586
89Furrowed tongue (HP:0000221)2.10578156
90Abnormality of the duodenum (HP:0002246)2.10264355
91Hypoplasia of the pons (HP:0012110)2.10133104
92Aplasia/Hypoplasia of the sternum (HP:0006714)2.09610701
93Abnormal biliary tract physiology (HP:0012439)2.09549274
94Bile duct proliferation (HP:0001408)2.09549274
95Protruding tongue (HP:0010808)2.07538224
96Generalized hypopigmentation of hair (HP:0011358)2.06782542
97Short tibia (HP:0005736)2.06305521
98Congenital hepatic fibrosis (HP:0002612)2.06116968
99Sloping forehead (HP:0000340)2.06092278
100Supernumerary spleens (HP:0009799)2.05232426
101Optic nerve hypoplasia (HP:0000609)2.04836966
102Premature graying of hair (HP:0002216)2.04570118
103Lipid accumulation in hepatocytes (HP:0006561)2.04086707
104Dry hair (HP:0011359)2.03709004
105Pancytopenia (HP:0001876)2.03432166
106Absent radius (HP:0003974)2.01817588
107Amaurosis fugax (HP:0100576)2.01161168
108True hermaphroditism (HP:0010459)2.00173138
109Hypergonadotropic hypogonadism (HP:0000815)2.00052095
110Abnormality of the carotid arteries (HP:0005344)1.98483189
111Nemaline bodies (HP:0003798)1.96276502
112Chorioretinal atrophy (HP:0000533)1.95558821
113IgM deficiency (HP:0002850)1.95504038
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95090420
115Abnormality of DNA repair (HP:0003254)1.94887550
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94483812
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.94022796
118Hypokalemic alkalosis (HP:0001949)1.93254264
119Muscle fiber inclusion bodies (HP:0100299)1.92650017
120Partial agenesis of the corpus callosum (HP:0001338)1.92467362
121Oral leukoplakia (HP:0002745)1.92373537
122Intestinal atresia (HP:0011100)1.90905139
123Abnormality of the labia minora (HP:0012880)1.89321913
124Abnormality of serine family amino acid metabolism (HP:0010894)1.87573350
125Abnormality of glycine metabolism (HP:0010895)1.87573350
126Pancreatic cysts (HP:0001737)1.87521057
127Aplasia involving forearm bones (HP:0009822)1.86638911
128Absent forearm bone (HP:0003953)1.86638911
129Abnormality of the columella (HP:0009929)1.86604925
130Abnormal urine output (HP:0012590)1.83542483
131Patchy hypopigmentation of hair (HP:0011365)1.82676129
132Abnormality of male internal genitalia (HP:0000022)1.82625419
133Abnormal rod and cone electroretinograms (HP:0008323)1.82594473
134Retinal dysplasia (HP:0007973)1.82138592
135Alveolar cell carcinoma (HP:0006519)1.81954810
136Absent septum pellucidum (HP:0001331)1.80429832
137Colon cancer (HP:0003003)1.80340285
138Severe muscular hypotonia (HP:0006829)1.79921086
139Renal cortical cysts (HP:0000803)1.79866136
140Congenital primary aphakia (HP:0007707)1.79847720
141Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.79211114
142Prolonged neonatal jaundice (HP:0006579)1.79075752
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79049516
144Gait imbalance (HP:0002141)1.77852760
145Abnormality of the septum pellucidum (HP:0007375)1.77360743
146Tracheoesophageal fistula (HP:0002575)1.77062827
147Metabolic alkalosis (HP:0200114)1.75839648
148Thrombocytosis (HP:0001894)1.75783307
149Absent/shortened dynein arms (HP:0200106)1.75567025
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.75567025
151Abnormality of incisor morphology (HP:0011063)1.74771510
152Tubulointerstitial abnormality (HP:0001969)1.74763213
153Anencephaly (HP:0002323)1.74670883
154Neuroendocrine neoplasm (HP:0100634)1.74451198
155Sparse scalp hair (HP:0002209)1.74395781
156Abnormal hair whorl (HP:0010721)1.74182493
157Pancreatic fibrosis (HP:0100732)1.73971336
158Lymphoma (HP:0002665)1.73006278
159Methylmalonic acidemia (HP:0002912)1.72560420
160Duplication of thumb phalanx (HP:0009942)1.72058324
161Pheochromocytoma (HP:0002666)1.71256402
162Nephroblastoma (Wilms tumor) (HP:0002667)1.71088857
163Medulloblastoma (HP:0002885)1.70816723
164Hypothermia (HP:0002045)1.70812302
165Cleft eyelid (HP:0000625)1.69026914
166Postaxial foot polydactyly (HP:0001830)1.68974899
167Methylmalonic aciduria (HP:0012120)1.68682932
168Petechiae (HP:0000967)1.68648314
169Aplasia/Hypoplasia of the fovea (HP:0008060)1.68633871
170Hypoplasia of the fovea (HP:0007750)1.68633871
171Aplasia/hypoplasia of the uterus (HP:0008684)1.67408537
172Bilateral sensorineural hearing impairment (HP:0008619)1.67141247
173Tongue fasciculations (HP:0001308)1.66239337
174Neoplasm of the adrenal gland (HP:0100631)1.65507279
175Ketoacidosis (HP:0001993)1.65034677
176Ketosis (HP:0001946)1.64499606
177Tubulointerstitial fibrosis (HP:0005576)1.63789933
178Bilateral microphthalmos (HP:0007633)1.63765858
179Decreased circulating renin level (HP:0003351)1.63521889
180Exercise-induced muscle cramps (HP:0003710)1.63379438
181Bony spicule pigmentary retinopathy (HP:0007737)1.62977658
182Hypochromic anemia (HP:0001931)1.62730729
183Agnosia (HP:0010524)1.62520681
184Leukopenia (HP:0001882)1.62412110
185Female pseudohermaphroditism (HP:0010458)1.61962591
186Genital tract atresia (HP:0001827)1.61874450
187Lip pit (HP:0100267)1.61804901
188Rough bone trabeculation (HP:0100670)1.61647570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.29957693
2ACVR1B3.13454895
3BUB12.79111165
4MAP4K22.67780442
5ZAK2.66574702
6OBSCN2.49330174
7WNK32.42753191
8NUAK12.41551642
9WEE12.33281228
10EIF2AK12.33043862
11TAOK32.31114777
12SRPK12.29610099
13CDC72.26587221
14MKNK12.23927390
15CAMKK22.23073254
16MKNK22.20044940
17CASK2.16920587
18VRK12.15935514
19WNK42.10941419
20STK162.02598772
21MAP3K141.89062649
22EIF2AK31.88375058
23TXK1.86196482
24IRAK41.82967624
25AKT31.80884854
26OXSR11.80692668
27MAP3K41.77951247
28EIF2AK21.76249045
29STK391.74480094
30PHKG21.73867883
31PHKG11.73867883
32STK38L1.69996534
33YES11.67925159
34TSSK61.62810760
35STK241.60945964
36SIK31.59585759
37BRSK21.58743443
38TEC1.58612573
39PLK41.57864413
40BCKDK1.52589413
41TAF11.52055704
42CAMK1D1.51281580
43IRAK31.49024770
44RPS6KA41.48179052
45TLK11.48178360
46PIM11.47816662
47BMPR1B1.44588823
48INSRR1.44467210
49DYRK31.42986696
50ADRBK21.42797842
51PLK31.41596487
52CDK81.40649099
53BMPR21.38750280
54NME21.33077891
55PLK11.31617521
56PNCK1.29970622
57ATR1.29666179
58CCNB11.27134541
59SGK21.22363401
60PINK11.18833394
61CDK31.18352797
62STK41.18190824
63IKBKB1.17255296
64TAOK21.13470667
65IKBKE1.11040422
66ERBB31.09465469
67PIM21.08594627
68CDK71.04435475
69PRPF4B1.03169393
70CAMK1G1.02161525
71BTK0.99127879
72AURKB0.98547492
73RPS6KB20.98536143
74PIK3CA0.98021037
75CHEK20.95558318
76PIK3CG0.95317239
77PAK30.95016681
78MAPK130.94884875
79MAPKAPK30.94099070
80TTK0.91971002
81CLK10.88623279
82NEK10.87214091
83GRK10.84013534
84TRIM280.83726928
85CHUK0.82658163
86PASK0.82379986
87VRK20.81905583
88JAK30.81386457
89MAP2K30.80982970
90TNIK0.80241621
91MAPKAPK50.80164806
92NLK0.79147477
93CSNK1G10.79132400
94MST40.78795212
95MAP4K10.73980398
96ADRBK10.73358075
97MAP2K60.72575228
98RPS6KA50.71309290
99PRKAA20.70686377
100TGFBR10.69583463
101NEK20.67989909
102PRKCE0.67758608
103AURKA0.65314550
104PLK20.63976346
105ATM0.63118853
106NEK90.61251477
107MAP2K20.61225030
108CSNK1G30.59579837
109MAP2K10.59051781
110BLK0.58873468
111CSNK2A10.57788021
112MUSK0.57271504
113MAP3K120.57161205
114PDK20.56934360
115SGK4940.56213476
116SGK2230.56213476
117CSNK1G20.55285304
118CHEK10.54743819
119MAP3K30.50700517
120SGK30.50636262
121CSNK1A1L0.50345079
122TIE10.50311309
123TNK20.49967107
124PRKCI0.47994624
125PRKCG0.47959361
126FLT30.47754699
127KIT0.47586563
128BRD40.47238430
129RPS6KA60.46849172
130PRKAA10.46463724
131CAMK10.46347937
132NEK60.46249620
133BRSK10.45306549
134PRKCQ0.44487330
135LYN0.44212579
136STK30.43399062
137CSNK2A20.43310498
138RPS6KB10.42785246
139DYRK20.42513791
140CDK20.42143994
141CDK40.41426819
142DAPK20.40285693
143ZAP700.39787954
144SYK0.39050046
145CAMK2A0.38954008
146MAP2K70.38240281
147TRPM70.38220342
148RPS6KC10.38156651
149RPS6KL10.38156651
150STK110.37981976
151CSNK1A10.34649302
152ITK0.33040132
153CAMK40.32910246
154CSNK1D0.31582936
155CAMKK10.28178838
156IGF1R0.27191703

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.25966417
2Mismatch repair_Homo sapiens_hsa034303.77892245
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54870126
4Homologous recombination_Homo sapiens_hsa034403.35186610
5Base excision repair_Homo sapiens_hsa034103.20300305
6RNA polymerase_Homo sapiens_hsa030203.19049106
7Ribosome_Homo sapiens_hsa030102.87214135
8Fanconi anemia pathway_Homo sapiens_hsa034602.79738517
9Nitrogen metabolism_Homo sapiens_hsa009102.75491811
10Butanoate metabolism_Homo sapiens_hsa006502.75453952
11Basal transcription factors_Homo sapiens_hsa030222.59043811
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57133596
13Nucleotide excision repair_Homo sapiens_hsa034202.52394635
14Proteasome_Homo sapiens_hsa030502.47365660
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44560641
16Spliceosome_Homo sapiens_hsa030402.41769744
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41331847
18Phototransduction_Homo sapiens_hsa047442.38936253
19Non-homologous end-joining_Homo sapiens_hsa034502.38421322
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36221856
21Pyrimidine metabolism_Homo sapiens_hsa002402.33786984
22Propanoate metabolism_Homo sapiens_hsa006402.20699025
23Caffeine metabolism_Homo sapiens_hsa002322.15738706
24One carbon pool by folate_Homo sapiens_hsa006702.14732801
25RNA transport_Homo sapiens_hsa030132.12999917
26Tryptophan metabolism_Homo sapiens_hsa003802.06695110
27Cell cycle_Homo sapiens_hsa041102.05712216
28RNA degradation_Homo sapiens_hsa030181.87297669
29Ether lipid metabolism_Homo sapiens_hsa005651.81241667
30Peroxisome_Homo sapiens_hsa041461.76532258
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65316636
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56756987
33Purine metabolism_Homo sapiens_hsa002301.53682584
34p53 signaling pathway_Homo sapiens_hsa041151.48179630
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46559010
36Vitamin B6 metabolism_Homo sapiens_hsa007501.38992129
37Herpes simplex infection_Homo sapiens_hsa051681.35101605
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.28130158
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24830026
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22035416
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.21280170
42mRNA surveillance pathway_Homo sapiens_hsa030151.20165336
43Oxidative phosphorylation_Homo sapiens_hsa001901.19019124
44Primary immunodeficiency_Homo sapiens_hsa053401.15196674
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12841010
46Allograft rejection_Homo sapiens_hsa053301.11065873
47Measles_Homo sapiens_hsa051621.09802383
48Sulfur metabolism_Homo sapiens_hsa009201.09002086
49ABC transporters_Homo sapiens_hsa020101.08291578
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08232887
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03324572
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.02126116
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99024452
54Epstein-Barr virus infection_Homo sapiens_hsa051690.99005101
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98004912
56Cardiac muscle contraction_Homo sapiens_hsa042600.96031957
57Taste transduction_Homo sapiens_hsa047420.95398265
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95158060
59beta-Alanine metabolism_Homo sapiens_hsa004100.93351597
60Fatty acid degradation_Homo sapiens_hsa000710.91877837
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91479736
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90871292
63Graft-versus-host disease_Homo sapiens_hsa053320.90670634
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89826093
65Parkinsons disease_Homo sapiens_hsa050120.89742718
66Systemic lupus erythematosus_Homo sapiens_hsa053220.89690029
67Legionellosis_Homo sapiens_hsa051340.89689687
68Protein export_Homo sapiens_hsa030600.89160704
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.87423641
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86939311
71Ovarian steroidogenesis_Homo sapiens_hsa049130.86752688
72Olfactory transduction_Homo sapiens_hsa047400.86527252
73Folate biosynthesis_Homo sapiens_hsa007900.81114154
74Chemical carcinogenesis_Homo sapiens_hsa052040.80715206
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80579949
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79550232
77Arachidonic acid metabolism_Homo sapiens_hsa005900.79403052
78Nicotine addiction_Homo sapiens_hsa050330.79024981
79Autoimmune thyroid disease_Homo sapiens_hsa053200.78520095
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77322675
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76008679
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74437428
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72631435
84Antigen processing and presentation_Homo sapiens_hsa046120.72465952
85Retinol metabolism_Homo sapiens_hsa008300.72260660
86Influenza A_Homo sapiens_hsa051640.70639215
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70375960
88Regulation of autophagy_Homo sapiens_hsa041400.69772659
89Asthma_Homo sapiens_hsa053100.69251446
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.68834194
91Hematopoietic cell lineage_Homo sapiens_hsa046400.68440473
92Fatty acid metabolism_Homo sapiens_hsa012120.68367442
93Serotonergic synapse_Homo sapiens_hsa047260.63998603
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62942989
95Dorso-ventral axis formation_Homo sapiens_hsa043200.62185083
96Morphine addiction_Homo sapiens_hsa050320.61720746
97Sulfur relay system_Homo sapiens_hsa041220.59539997
98HTLV-I infection_Homo sapiens_hsa051660.58347999
99Leishmaniasis_Homo sapiens_hsa051400.57155384
100Arginine and proline metabolism_Homo sapiens_hsa003300.56232455
101Viral carcinogenesis_Homo sapiens_hsa052030.55501428
102Histidine metabolism_Homo sapiens_hsa003400.54406581
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.54377611
104Other glycan degradation_Homo sapiens_hsa005110.54265814
105Calcium signaling pathway_Homo sapiens_hsa040200.52391772
106Pyruvate metabolism_Homo sapiens_hsa006200.51822955
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.51442974
108Glutathione metabolism_Homo sapiens_hsa004800.51194475
109Fatty acid elongation_Homo sapiens_hsa000620.48566113
110Steroid biosynthesis_Homo sapiens_hsa001000.47257622
111Pentose phosphate pathway_Homo sapiens_hsa000300.47173705
112Apoptosis_Homo sapiens_hsa042100.46347532
113Fatty acid biosynthesis_Homo sapiens_hsa000610.45882693
114Fat digestion and absorption_Homo sapiens_hsa049750.45696023
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44303339
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43566688
117Glycerolipid metabolism_Homo sapiens_hsa005610.43524428
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42551717
119Thyroid cancer_Homo sapiens_hsa052160.42247326
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41813116
121N-Glycan biosynthesis_Homo sapiens_hsa005100.40520971
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40400292
123Alzheimers disease_Homo sapiens_hsa050100.40304281
124Long-term depression_Homo sapiens_hsa047300.39601201
125Circadian rhythm_Homo sapiens_hsa047100.39034137
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39021326
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38129140
128Type I diabetes mellitus_Homo sapiens_hsa049400.36200016
129Salivary secretion_Homo sapiens_hsa049700.35392617
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.35356093
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34922636
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34024124
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32993821
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32507637
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32040482
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30383311
137Hepatitis B_Homo sapiens_hsa051610.30011900
138Acute myeloid leukemia_Homo sapiens_hsa052210.29637288
139Shigellosis_Homo sapiens_hsa051310.28882276
140Huntingtons disease_Homo sapiens_hsa050160.28860062
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28540308
142Lysine degradation_Homo sapiens_hsa003100.28515693
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.28161468
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27987275
145Metabolic pathways_Homo sapiens_hsa011000.27400315
146Basal cell carcinoma_Homo sapiens_hsa052170.26307735
147TNF signaling pathway_Homo sapiens_hsa046680.24134831
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23846728
149Sphingolipid metabolism_Homo sapiens_hsa006000.23800249
150Rheumatoid arthritis_Homo sapiens_hsa053230.23721735
151Small cell lung cancer_Homo sapiens_hsa052220.22256068
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.21993290
153Selenocompound metabolism_Homo sapiens_hsa004500.20330171
154Linoleic acid metabolism_Homo sapiens_hsa005910.19361554
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.19204427
156Alcoholism_Homo sapiens_hsa050340.17571033
157Prostate cancer_Homo sapiens_hsa052150.17202536
158FoxO signaling pathway_Homo sapiens_hsa040680.17095594

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