DTX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.88624631
2regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.39574162
3piRNA metabolic process (GO:0034587)5.27330647
4mitotic chromosome condensation (GO:0007076)5.21447563
5regulation of female gonad development (GO:2000194)4.90302570
6regulation of histone H3-K27 methylation (GO:0061085)4.87926378
7metaphase plate congression (GO:0051310)4.86315968
8regulation of meiosis (GO:0040020)4.83451195
9regulation of meiosis I (GO:0060631)4.80179111
10response to peptidoglycan (GO:0032494)4.73260601
11female gamete generation (GO:0007292)4.62142059
12negative regulation of interleukin-12 production (GO:0032695)4.54114608
13negative regulation of meiosis (GO:0045835)4.47056267
14protein K6-linked ubiquitination (GO:0085020)4.44836617
15DNA damage response, signal transduction resulting in transcription (GO:0042772)4.44823103
16mitotic sister chromatid segregation (GO:0000070)4.42590090
17protein localization to kinetochore (GO:0034501)4.41351439
18protein localization to chromosome, centromeric region (GO:0071459)4.40403906
19DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.37767219
20regulation of RIG-I signaling pathway (GO:0039535)4.35067167
21negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.33935618
22meiotic cell cycle (GO:0051321)4.31444936
23establishment of chromosome localization (GO:0051303)4.23329506
24macrophage activation involved in immune response (GO:0002281)4.22961313
25immunoglobulin mediated immune response (GO:0016064)4.22662926
26histone H2A monoubiquitination (GO:0035518)4.20370611
27regulation of spindle organization (GO:0090224)4.14938184
28regulation of exit from mitosis (GO:0007096)4.09798065
29attachment of spindle microtubules to kinetochore (GO:0008608)4.06591358
30maturation of 5.8S rRNA (GO:0000460)4.03323814
31modulation by symbiont of host defense response (GO:0052031)4.02841950
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.02841950
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.02841950
34positive regulation by organism of defense response of other organism involved in symbiotic interact4.02841950
35modulation by symbiont of host immune response (GO:0052553)4.02841950
36positive regulation by symbiont of host defense response (GO:0052509)4.02841950
37regulation of sister chromatid cohesion (GO:0007063)4.02527253
38DNA damage induced protein phosphorylation (GO:0006975)3.99772452
39protein localization to chromosome (GO:0034502)3.96685748
40response to type I interferon (GO:0034340)3.91833630
41germinal center formation (GO:0002467)3.91131777
42cellular response to type I interferon (GO:0071357)3.91040736
43type I interferon signaling pathway (GO:0060337)3.91040736
44mitotic nuclear envelope disassembly (GO:0007077)3.90632150
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.88069281
46negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.87730713
47neutrophil activation involved in immune response (GO:0002283)3.86917440
48oocyte maturation (GO:0001556)3.84864842
49meiotic chromosome segregation (GO:0045132)3.80563473
50regulation of vitamin D biosynthetic process (GO:0060556)3.79027672
51male meiosis (GO:0007140)3.75878388
52monoubiquitinated protein deubiquitination (GO:0035520)3.75769078
53regulation of mitotic spindle organization (GO:0060236)3.74794545
54regulation of meiotic cell cycle (GO:0051445)3.74475761
55regulation of chromosome segregation (GO:0051983)3.74299386
56positive regulation of chromosome segregation (GO:0051984)3.73735216
57positive regulation of gamma-delta T cell activation (GO:0046645)3.72075132
58regulation of podosome assembly (GO:0071801)3.66486670
59sister chromatid segregation (GO:0000819)3.65570180
60histone H2A ubiquitination (GO:0033522)3.64905599
61membrane disassembly (GO:0030397)3.64388742
62nuclear envelope disassembly (GO:0051081)3.64388742
63negative regulation of cell killing (GO:0031342)3.63965454
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63965454
65spindle checkpoint (GO:0031577)3.63715835
66negative regulation of meiotic cell cycle (GO:0051447)3.58408048
67regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.56238903
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.56055898
69negative regulation of histone methylation (GO:0031061)3.55011334
70negative regulation of DNA-templated transcription, elongation (GO:0032785)3.52813980
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.52813980
72DNA replication checkpoint (GO:0000076)3.51449679
73defense response to protozoan (GO:0042832)3.49205962
74T-helper 1 type immune response (GO:0042088)3.48508518
75chromosome segregation (GO:0007059)3.46974055
76DNA methylation involved in gamete generation (GO:0043046)3.46968984
77response to protozoan (GO:0001562)3.46945775
78negative regulation of chromosome segregation (GO:0051985)3.45980752
79positive regulation of Cdc42 GTPase activity (GO:0043089)3.45401501
80regulation of interferon-beta biosynthetic process (GO:0045357)3.44624863
81mitotic spindle checkpoint (GO:0071174)3.43970299
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41782623
83CENP-A containing nucleosome assembly (GO:0034080)3.40228386
84DNA replication-independent nucleosome assembly (GO:0006336)3.40138582
85DNA replication-independent nucleosome organization (GO:0034724)3.40138582
86gene silencing by RNA (GO:0031047)3.36902066
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36357459
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36357459
89negative regulation of sister chromatid segregation (GO:0033046)3.36357459
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.36357459
91detection of other organism (GO:0098543)3.35131197
92chromatin remodeling at centromere (GO:0031055)3.35114319
93myeloid dendritic cell differentiation (GO:0043011)3.35037109
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.33333436
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.33333436
96positive regulation of mitotic sister chromatid separation (GO:1901970)3.33333436
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.33258692
98regulation of retinoic acid receptor signaling pathway (GO:0048385)3.32395819
99detection of bacterium (GO:0016045)3.32149639
100interferon-gamma-mediated signaling pathway (GO:0060333)3.30846192
101mitotic spindle assembly checkpoint (GO:0007094)3.29310848
102regulation of DNA methylation (GO:0044030)3.29059026
103regulation of T-helper 1 cell differentiation (GO:0045625)3.28467306
104regulation of cytokine secretion involved in immune response (GO:0002739)3.28211317
105response to muramyl dipeptide (GO:0032495)3.27358474
106negative regulation of cytokine production involved in immune response (GO:0002719)3.27159770
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26865521
108positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.25782725
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24238938
110regulation of interferon-alpha production (GO:0032647)3.23849589
111chromatin assembly or disassembly (GO:0006333)3.23151188
112regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21419658
113spindle assembly checkpoint (GO:0071173)3.21240563
114positive regulation of DNA-dependent DNA replication (GO:2000105)3.19646758
115antigen processing and presentation of endogenous antigen (GO:0019883)3.18557257
116kinetochore assembly (GO:0051382)3.17663462
117regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15893289
118regulation of vitamin metabolic process (GO:0030656)3.14814386
119regulation of sister chromatid segregation (GO:0033045)3.12427404
120regulation of mitotic sister chromatid separation (GO:0010965)3.12427404
121regulation of mitotic sister chromatid segregation (GO:0033047)3.12427404
122folic acid-containing compound biosynthetic process (GO:0009396)3.10724431
123positive regulation of megakaryocyte differentiation (GO:0045654)3.09823521
124negative regulation of hormone metabolic process (GO:0032351)3.09243828
125negative regulation of hormone biosynthetic process (GO:0032353)3.09243828
126positive regulation of chemokine biosynthetic process (GO:0045080)3.09101709
127B cell mediated immunity (GO:0019724)3.08656404
128regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07992755
129granulocyte activation (GO:0036230)3.05760213
130histone exchange (GO:0043486)3.04425048
131nuclear envelope organization (GO:0006998)3.03831042
132regulation of chemokine biosynthetic process (GO:0045073)3.02112259
133inner cell mass cell proliferation (GO:0001833)3.00222891
134positive regulation of antigen processing and presentation (GO:0002579)2.99087999
135regulation of gamma-delta T cell activation (GO:0046643)2.98314309
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.97721314
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97709638
138mitotic sister chromatid cohesion (GO:0007064)2.97171719
139synaptonemal complex assembly (GO:0007130)2.96963199
140negative regulation of nuclear division (GO:0051784)2.95594291
141meiotic cell cycle process (GO:1903046)2.95320869
142regulation of antigen processing and presentation (GO:0002577)2.95042593
143interferon-gamma secretion (GO:0072643)2.92653275
144myeloid dendritic cell activation (GO:0001773)2.92030230
145kinetochore organization (GO:0051383)2.91463690
146meiotic nuclear division (GO:0007126)2.91081627
147positive regulation of interferon-alpha production (GO:0032727)2.90890869
148regulation of telomere maintenance via telomerase (GO:0032210)2.89796893
149NIK/NF-kappaB signaling (GO:0038061)2.89774378
150regulation of transforming growth factor beta2 production (GO:0032909)2.89353516
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88750952
152positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88466468
153negative regulation of myeloid cell apoptotic process (GO:0033033)2.88224176
154type B pancreatic cell development (GO:0003323)2.86612316
155sister chromatid cohesion (GO:0007062)2.86462107
156DNA methylation (GO:0006306)2.86337675
157DNA alkylation (GO:0006305)2.86337675
158DNA replication initiation (GO:0006270)2.85891828
159positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84917947
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84453554
161detection of external biotic stimulus (GO:0098581)2.84191169
162positive regulation of NF-kappaB import into nucleus (GO:0042346)2.83675748
163regulation of T-helper 2 cell differentiation (GO:0045628)2.80241495
164positive regulation of type 2 immune response (GO:0002830)2.79574104
165leukocyte aggregation (GO:0070486)2.78278567
166myeloid cell activation involved in immune response (GO:0002275)2.78156966
167mature B cell differentiation involved in immune response (GO:0002313)2.75571352
168neutrophil activation (GO:0042119)2.75413032
169regulation of mast cell degranulation (GO:0043304)2.70957941
170tolerance induction (GO:0002507)2.70273499
171glycosphingolipid catabolic process (GO:0046479)2.70243204
172negative regulation of innate immune response (GO:0045824)2.69663208
173positive regulation of heat generation (GO:0031652)2.68385403
174modulation by symbiont of host cellular process (GO:0044068)2.67273614
175cellular response to interferon-gamma (GO:0071346)2.66133844
176negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.65334687
177dendritic cell differentiation (GO:0097028)2.64564136
178detection of molecule of bacterial origin (GO:0032490)2.64384145
179negative regulation of interleukin-6 production (GO:0032715)2.63620601
180positive regulation of interferon-beta production (GO:0032728)2.62497049
181negative regulation of erythrocyte differentiation (GO:0045647)2.61020922
182hydrogen peroxide biosynthetic process (GO:0050665)2.60730433
183positive regulation of transcription factor import into nucleus (GO:0042993)2.60655127
184respiratory burst (GO:0045730)2.59687854
185regulation of chronic inflammatory response (GO:0002676)2.58539538
186regulation of interleukin-12 production (GO:0032655)2.58391052
187positive regulation of defense response to virus by host (GO:0002230)2.57939656
188response to interferon-gamma (GO:0034341)2.56373325
189regulation of type 2 immune response (GO:0002828)2.55809176
190cellular response to virus (GO:0098586)2.54904498
191branching involved in labyrinthine layer morphogenesis (GO:0060670)2.54891641
192regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.53898707
193response to host immune response (GO:0052572)2.53773517
194response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53773517
195regulation of interferon-beta production (GO:0032648)2.51418953
196macrophage activation (GO:0042116)2.51298545
197regulation of interleukin-8 biosynthetic process (GO:0045414)2.50687679
198cellular response to lipopolysaccharide (GO:0071222)2.50536077
199negative regulation of production of molecular mediator of immune response (GO:0002701)2.49737760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36890808
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.84885021
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.66123064
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.94922446
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25598266
6AR_21909140_ChIP-Seq_LNCAP_Human3.19475919
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.00802608
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.93091799
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.82496966
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.74067455
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65956160
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.57921940
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41282817
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.37038869
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.35781044
16MYC_22102868_ChIP-Seq_BL_Human2.34235696
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.32753300
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31006949
19VDR_24763502_ChIP-Seq_THP-1_Human2.26535247
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23127812
21LXR_22292898_ChIP-Seq_THP-1_Human2.22394853
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.18570714
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.11768616
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04416736
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99326853
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.96687414
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96610702
28* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96255353
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95802385
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92445178
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.91548197
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.87771194
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86941067
34MAF_26560356_Chip-Seq_TH1_Human1.86832421
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85025757
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83124668
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81400463
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77163712
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77051583
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76744036
41RACK7_27058665_Chip-Seq_MCF-7_Human1.76555537
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75714514
43* SPI1_23127762_ChIP-Seq_K562_Human1.75338399
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71568249
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.71456180
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69171146
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.68198348
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.64373383
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64116729
50KDM2B_26808549_Chip-Seq_DND41_Human1.63929927
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.63604478
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63301159
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.62157696
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.55818558
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53576681
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53144945
57BCL6_27268052_Chip-Seq_Bcells_Human1.51262151
58SCL_19346495_ChIP-Seq_HPC-7_Human1.50270060
59BCOR_27268052_Chip-Seq_Bcells_Human1.50114709
60GABP_19822575_ChIP-Seq_HepG2_Human1.49482098
61MAF_26560356_Chip-Seq_TH2_Human1.48163892
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47331886
63KDM5A_27292631_Chip-Seq_BREAST_Human1.46858120
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46625148
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46034378
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45478235
67CIITA_25753668_ChIP-Seq_RAJI_Human1.44739478
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44661732
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41161638
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40492037
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37648396
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35889529
73P68_20966046_ChIP-Seq_HELA_Human1.35027229
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33674418
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32516263
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30116204
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.30013866
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29040573
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.28989147
80XRN2_22483619_ChIP-Seq_HELA_Human1.28402455
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.27752164
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27383978
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27004585
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26987616
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26307313
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.25588980
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21645457
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21560128
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.21422713
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20852013
91DCP1A_22483619_ChIP-Seq_HELA_Human1.20453723
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20001237
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19951924
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19782214
95VDR_21846776_ChIP-Seq_THP-1_Human1.19051430
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18838544
97SMC4_20622854_ChIP-Seq_HELA_Human1.18427587
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17539578
99NCOR1_26117541_ChIP-Seq_K562_Human1.17415253
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16682856
101MYC_18940864_ChIP-ChIP_HL60_Human1.16556521
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16478974
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16053896
104MYB_26560356_Chip-Seq_TH1_Human1.15831770
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15724886
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15552160
107VDR_23849224_ChIP-Seq_CD4+_Human1.15140179
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14825939
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14016500
110* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13445437
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12895941
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12124065
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12017784
114TCF7_22412390_ChIP-Seq_EML_Mouse1.12003419
115E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11181070
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10853189
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09933347
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09295842
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09287600
120ESR1_21235772_ChIP-Seq_MCF-7_Human1.09177196
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08254683
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.07944545
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07870799
124* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07826764
125VDR_24787735_ChIP-Seq_THP-1_Human1.07664082
126* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07556086
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06482182
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06045772
129RUNX_20019798_ChIP-Seq_JUKART_Human1.05586840
130ATF3_27146783_Chip-Seq_COLON_Human1.05254206
131KDM2B_26808549_Chip-Seq_K562_Human1.03945464
132CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03568109
133STAT1_20625510_ChIP-Seq_HELA_Human1.03476518
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03432340
135GATA1_19941826_ChIP-Seq_K562_Human1.02140847
136GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02097773
137PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01291838
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00445164
139MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00298377
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.99731659
141PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99360987
142FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99157887
143PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99100055
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.98890688
145CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98482543
146NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98153915
147* KAP1_27257070_Chip-Seq_ESCs_Mouse0.96488067
148EST1_17652178_ChIP-ChIP_JURKAT_Human0.96363507
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95424350
150FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94255391
151UTX_26944678_Chip-Seq_JUKART_Human0.93634008
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93405177
153POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92529180
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92464105
155CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89175829
156FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88110909
157TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87843248
158HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87171660
159EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86399121
160TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85343716
161* IRF8_21731497_ChIP-ChIP_J774_Mouse0.85153513
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84905298
163* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84738087
164FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84383007
165TTF2_22483619_ChIP-Seq_HELA_Human0.83638186
166TFEB_21752829_ChIP-Seq_HELA_Human0.81653964
167FOXP3_21729870_ChIP-Seq_TREG_Human0.81102980
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80592804
169SPI1_23547873_ChIP-Seq_NB4_Human0.79752404
170* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79331032
171MYB_26560356_Chip-Seq_TH2_Human0.77453770
172KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77246482
173HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77061783
174KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77048660
175* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75669017
176TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73839982
177DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73627055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.51625299
2MP0003693_abnormal_embryo_hatching4.31649872
3MP0003303_peritoneal_inflammation4.28199280
4MP0003646_muscle_fatigue4.05578033
5MP0003436_decreased_susceptibility_to3.73031003
6MP0003718_maternal_effect3.59192122
7MP0003111_abnormal_nucleus_morphology3.54833338
8MP0010094_abnormal_chromosome_stability3.46622525
9MP0002102_abnormal_ear_morphology3.32120032
10MP0003077_abnormal_cell_cycle3.25501157
11MP0002653_abnormal_ependyma_morphology3.11093965
12MP0005058_abnormal_lysosome_morphology3.06302970
13MP0003724_increased_susceptibility_to3.03628079
14MP0002148_abnormal_hypersensitivity_rea2.98316197
15MP0008877_abnormal_DNA_methylation2.87231188
16MP0009785_altered_susceptibility_to2.80631108
17MP0004957_abnormal_blastocyst_morpholog2.79202487
18MP0001790_abnormal_immune_system2.69140518
19MP0005387_immune_system_phenotype2.69140518
20MP0006082_CNS_inflammation2.67875786
21MP0001835_abnormal_antigen_presentation2.61090230
22MP0005025_abnormal_response_to2.53392568
23MP0002419_abnormal_innate_immunity2.53304434
24MP0005000_abnormal_immune_tolerance2.42641928
25MP0005671_abnormal_response_to2.32872109
26MP0003191_abnormal_cellular_cholesterol2.15516821
27MP0004947_skin_inflammation2.14062708
28MP0003123_paternal_imprinting2.14003255
29MP0002723_abnormal_immune_serum2.11823375
30MP0003300_gastrointestinal_ulcer2.11439272
31MP0003806_abnormal_nucleotide_metabolis2.11187828
32MP0001119_abnormal_female_reproductive2.08758978
33MP0010155_abnormal_intestine_physiology2.02825650
34MP0002139_abnormal_hepatobiliary_system1.97934089
35MP0001533_abnormal_skeleton_physiology1.95456785
36MP0004185_abnormal_adipocyte_glucose1.92422925
37MP0009764_decreased_sensitivity_to1.90604817
38MP0002254_reproductive_system_inflammat1.87661687
39MP0008007_abnormal_cellular_replicative1.87531398
40MP0001819_abnormal_immune_cell1.87380158
41MP0002420_abnormal_adaptive_immunity1.86627086
42MP0003172_abnormal_lysosome_physiology1.85586608
43MP0003699_abnormal_female_reproductive1.80199485
44MP0001929_abnormal_gametogenesis1.75742863
45MP0003075_altered_response_to1.75547527
46MP0002210_abnormal_sex_determination1.74348292
47MP0000350_abnormal_cell_proliferation1.69101241
48MP0001845_abnormal_inflammatory_respons1.67380587
49MP0001730_embryonic_growth_arrest1.67282229
50MP0000653_abnormal_sex_gland1.66912952
51MP0008932_abnormal_embryonic_tissue1.65783295
52MP0005395_other_phenotype1.63380834
53MP0008469_abnormal_protein_level1.52553809
54MP0008057_abnormal_DNA_replication1.51903660
55MP0005464_abnormal_platelet_physiology1.49788947
56MP0010307_abnormal_tumor_latency1.49651702
57MP0001697_abnormal_embryo_size1.47829587
58MP0008058_abnormal_DNA_repair1.47242859
59MP0000343_altered_response_to1.46183980
60MP0001853_heart_inflammation1.45868427
61MP0002085_abnormal_embryonic_tissue1.43611310
62MP0005380_embryogenesis_phenotype1.40052729
63MP0001672_abnormal_embryogenesis/_devel1.40052729
64MP0001915_intracranial_hemorrhage1.37526462
65MP0005670_abnormal_white_adipose1.36885778
66MP0002998_abnormal_bone_remodeling1.36784329
67MP0000490_abnormal_crypts_of1.35645577
68MP0002249_abnormal_larynx_morphology1.35262926
69MP0005310_abnormal_salivary_gland1.35230130
70MP0003763_abnormal_thymus_physiology1.34423472
71MP0004510_myositis1.32079225
72MP0002019_abnormal_tumor_incidence1.31746617
73MP0008004_abnormal_stomach_pH1.29266072
74MP0008260_abnormal_autophagy1.29214621
75MP0009333_abnormal_splenocyte_physiolog1.28458618
76MP0002877_abnormal_melanocyte_morpholog1.28365072
77MP0001145_abnormal_male_reproductive1.28238036
78MP0005076_abnormal_cell_differentiation1.27650992
79MP0002138_abnormal_hepatobiliary_system1.26733127
80MP0001873_stomach_inflammation1.25401943
81MP0002084_abnormal_developmental_patter1.23983947
82MP0005408_hypopigmentation1.19885713
83MP0001849_ear_inflammation1.18575221
84MP0005166_decreased_susceptibility_to1.17467581
85MP0003984_embryonic_growth_retardation1.17461757
86MP0002088_abnormal_embryonic_growth/wei1.14612484
87MP0002796_impaired_skin_barrier1.14356628
88MP0000604_amyloidosis1.13830629
89MP0010352_gastrointestinal_tract_polyps1.12181201
90MP0004264_abnormal_extraembryonic_tissu1.10295147
91MP0002396_abnormal_hematopoietic_system1.09536948
92MP0003183_abnormal_peptide_metabolism1.08474970
93MP0003937_abnormal_limbs/digits/tail_de1.06633955
94MP0001545_abnormal_hematopoietic_system1.06352556
95MP0005397_hematopoietic_system_phenotyp1.06352556
96MP0000579_abnormal_nail_morphology1.05964433
97MP0003453_abnormal_keratinocyte_physiol1.04289011
98MP0006292_abnormal_olfactory_placode1.04042686
99MP0002332_abnormal_exercise_endurance1.03965705
100MP0002161_abnormal_fertility/fecundity1.01542854
101MP0002080_prenatal_lethality1.00986355
102MP0003121_genomic_imprinting0.99821748
103MP0002086_abnormal_extraembryonic_tissu0.99409498
104MP0003786_premature_aging0.97038888
105MP0003705_abnormal_hypodermis_morpholog0.95894846
106MP0001663_abnormal_digestive_system0.94276223
107MP0005621_abnormal_cell_physiology0.94119620
108MP0005167_abnormal_blood-brain_barrier0.93639165
109MP0003221_abnormal_cardiomyocyte_apopto0.93557615
110MP0000733_abnormal_muscle_development0.93527548
111MP0003656_abnormal_erythrocyte_physiolo0.93521720
112MP0004808_abnormal_hematopoietic_stem0.93067635
113MP0009278_abnormal_bone_marrow0.91274902
114MP0002277_abnormal_respiratory_mucosa0.90507412
115MP0004858_abnormal_nervous_system0.89817817
116MP0005023_abnormal_wound_healing0.89782287
117MP0005164_abnormal_response_to0.89397942
118MP0001216_abnormal_epidermal_layer0.88666884
119MP0002398_abnormal_bone_marrow0.87684156
120MP0005390_skeleton_phenotype0.87363776
121MP0010030_abnormal_orbit_morphology0.87199478
122MP0000313_abnormal_cell_death0.87019776
123MP0009840_abnormal_foam_cell0.86947778
124MP0005666_abnormal_adipose_tissue0.86353596
125MP0003866_abnormal_defecation0.84769537
126MP0000465_gastrointestinal_hemorrhage0.83746873
127MP0003828_pulmonary_edema0.82411795
128MP0000569_abnormal_digit_pigmentation0.81174702
129MP0005257_abnormal_intraocular_pressure0.81076955
130MP0003566_abnormal_cell_adhesion0.79476583
131MP0009763_increased_sensitivity_to0.76467217
132MP0000703_abnormal_thymus_morphology0.76215864
133MP0000689_abnormal_spleen_morphology0.75920051
134MP0002132_abnormal_respiratory_system0.75352987
135MP0000685_abnormal_immune_system0.75240817
136MP0010234_abnormal_vibrissa_follicle0.75206104
137MP0001800_abnormal_humoral_immune0.74715799
138MP0000678_abnormal_parathyroid_gland0.72782687
139MP0000462_abnormal_digestive_system0.72123359
140MP0000858_altered_metastatic_potential0.71340145
141MP0002722_abnormal_immune_system0.71188623
142MP0006054_spinal_hemorrhage0.70020263
143MP0005384_cellular_phenotype0.69279951
144MP0002933_joint_inflammation0.68149358
145MP0009765_abnormal_xenobiotic_induced0.67857778
146MP0005501_abnormal_skin_physiology0.67783594
147MP0001851_eye_inflammation0.67507334
148MP0004883_abnormal_blood_vessel0.66399633
149MP0003315_abnormal_perineum_morphology0.66121434
150MP0003448_altered_tumor_morphology0.65946457
151MP0002405_respiratory_system_inflammati0.65068956
152MP0005319_abnormal_enzyme/_coenzyme0.64428856
153MP0003698_abnormal_male_reproductive0.64070978
154MP0002452_abnormal_antigen_presenting0.63403320
155MP0005165_increased_susceptibility_to0.61412439
156MP0002177_abnormal_outer_ear0.61370521
157MP0003795_abnormal_bone_structure0.61146556
158MP0002429_abnormal_blood_cell0.60712068
159MP0003091_abnormal_cell_migration0.60611781
160MP0010368_abnormal_lymphatic_system0.60368556
161MP0005381_digestive/alimentary_phenotyp0.59388416
162MP0005508_abnormal_skeleton_morphology0.59379536
163MP0000609_abnormal_liver_physiology0.59323534
164MP0000716_abnormal_immune_system0.58965351
165MP0000249_abnormal_blood_vessel0.58486555
166MP0000767_abnormal_smooth_muscle0.58058597
167MP0003755_abnormal_palate_morphology0.56202371

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)5.68159539
2Abnormality of liposaccharide metabolism (HP:0010968)5.12466870
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.12466870
4Abnormality of glycolipid metabolism (HP:0010969)5.12466870
5Abnormality of macrophages (HP:0004311)4.78499193
6Eczematoid dermatitis (HP:0000976)4.73178040
7Recurrent bacterial skin infections (HP:0005406)4.67360185
8Chromsome breakage (HP:0040012)4.59342486
9Recurrent abscess formation (HP:0002722)4.45684908
10Birth length less than 3rd percentile (HP:0003561)4.43207927
11Breast hypoplasia (HP:0003187)4.38431922
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.38316497
13Myositis (HP:0100614)4.30763227
14Orchitis (HP:0100796)4.25124190
15Increased cerebral lipofuscin (HP:0011813)4.19444592
16Loss of speech (HP:0002371)4.18221631
17Patellar aplasia (HP:0006443)3.79276909
18Abnormality of the fingertips (HP:0001211)3.71920558
19Systemic lupus erythematosus (HP:0002725)3.67701999
20Vacuolated lymphocytes (HP:0001922)3.67212004
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.67091646
22Mediastinal lymphadenopathy (HP:0100721)3.61296845
23Stomatitis (HP:0010280)3.59592018
24Dysostosis multiplex (HP:0000943)3.57911245
25Aplasia/Hypoplasia of the patella (HP:0006498)3.54568447
26Elevated erythrocyte sedimentation rate (HP:0003565)3.50976156
27Malnutrition (HP:0004395)3.23939029
28Nasal polyposis (HP:0100582)3.23024426
29Increased IgE level (HP:0003212)3.21416614
30Abnormality of the nasal mucosa (HP:0000433)3.20963530
31Adrenal hypoplasia (HP:0000835)3.19950331
32Facial hemangioma (HP:0000329)3.18866224
33Secondary amenorrhea (HP:0000869)3.16337700
34Premature ovarian failure (HP:0008209)3.13071840
35Recurrent gram-negative bacterial infections (HP:0005420)3.11603074
36Shawl scrotum (HP:0000049)3.07549753
37Abnormality of chromosome stability (HP:0003220)3.07032969
38Increased serum ferritin (HP:0003281)3.05848599
39Aplasia/Hypoplasia of the uvula (HP:0010293)3.01384767
40Autoimmune thrombocytopenia (HP:0001973)2.91054137
41Ectopic kidney (HP:0000086)2.90725788
42Meckel diverticulum (HP:0002245)2.87931571
43Flat capital femoral epiphysis (HP:0003370)2.84946576
44Pulmonary fibrosis (HP:0002206)2.83549431
45Axonal loss (HP:0003447)2.79665258
46Abnormality of the preputium (HP:0100587)2.79361724
47Obstructive lung disease (HP:0006536)2.79106429
48Chronic obstructive pulmonary disease (HP:0006510)2.79106429
49Abnormality of polysaccharide metabolism (HP:0011012)2.72727750
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72727750
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72727750
52Capillary hemangiomas (HP:0005306)2.71484507
53Abnormality of the ileum (HP:0001549)2.70952734
54Recurrent fungal infections (HP:0002841)2.70662651
55Pustule (HP:0200039)2.69526347
56Vasculitis (HP:0002633)2.68298329
57Hypergonadotropic hypogonadism (HP:0000815)2.67568367
58Breast aplasia (HP:0100783)2.67496014
59Recurrent skin infections (HP:0001581)2.66572540
60Carpal bone hypoplasia (HP:0001498)2.66474650
61Nuclear cataract (HP:0100018)2.66132743
62Interstitial pulmonary disease (HP:0006530)2.65406692
63Abnormality of the labia minora (HP:0012880)2.63228347
64Aplasia/Hypoplasia of the breasts (HP:0010311)2.62312111
65Disinhibition (HP:0000734)2.62222117
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.60362727
67Small intestinal stenosis (HP:0012848)2.56862776
68Duodenal stenosis (HP:0100867)2.56862776
69Gingivitis (HP:0000230)2.56817959
70Papillary thyroid carcinoma (HP:0002895)2.56628122
71Oral leukoplakia (HP:0002745)2.56121036
72Keratoconjunctivitis sicca (HP:0001097)2.55865527
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.55720462
74Acute myeloid leukemia (HP:0004808)2.55293318
75Myelodysplasia (HP:0002863)2.54504690
76Petechiae (HP:0000967)2.53457999
77Mucopolysacchariduria (HP:0008155)2.51963950
78Urinary glycosaminoglycan excretion (HP:0003541)2.51963950
79Meningitis (HP:0001287)2.51829196
80Increased IgM level (HP:0003496)2.48868386
81Urticaria (HP:0001025)2.48808980
82Amyloidosis (HP:0011034)2.43778264
83Absent radius (HP:0003974)2.41403855
84Purpura (HP:0000979)2.39618843
85Rib fusion (HP:0000902)2.39082000
86Sparse lateral eyebrow (HP:0005338)2.37856560
87Recurrent viral infections (HP:0004429)2.35360557
88Pulmonary infiltrates (HP:0002113)2.33195483
89Clubbing of toes (HP:0100760)2.32118046
90Cellulitis (HP:0100658)2.31715641
91Overlapping toe (HP:0001845)2.30048277
92Abnormality of iron homeostasis (HP:0011031)2.28470579
93Lip pit (HP:0100267)2.28283905
94Abnormality of lateral ventricle (HP:0030047)2.27772452
95Keratoconjunctivitis (HP:0001096)2.27560746
96Prostate neoplasm (HP:0100787)2.27063160
97Absent forearm bone (HP:0003953)2.26516151
98Aplasia involving forearm bones (HP:0009822)2.26516151
99Hemoptysis (HP:0002105)2.26253934
100Colitis (HP:0002583)2.26041606
101Neurofibrillary tangles (HP:0002185)2.25613001
102Gastrointestinal infarctions (HP:0005244)2.24437438
103Cafe-au-lait spot (HP:0000957)2.22833386
104Short thumb (HP:0009778)2.20968981
105Gangrene (HP:0100758)2.20895740
106Glomerulonephritis (HP:0000099)2.19795286
107Prolonged neonatal jaundice (HP:0006579)2.19751802
108Rhabdomyosarcoma (HP:0002859)2.19073889
109Premature loss of primary teeth (HP:0006323)2.18843645
110Spondylolisthesis (HP:0003302)2.18695343
111Gastrointestinal inflammation (HP:0004386)2.18445166
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.17569849
113Neuronal loss in central nervous system (HP:0002529)2.17511802
114Oligodactyly (HP:0012165)2.17301270
115Gastrointestinal stroma tumor (HP:0100723)2.16049695
116Abnormality of the carotid arteries (HP:0005344)2.15560736
117Sandal gap (HP:0001852)2.15242730
118Hypergammaglobulinemia (HP:0010702)2.15223516
119Abnormality of the intervertebral disk (HP:0005108)2.14999304
120Inflammation of the large intestine (HP:0002037)2.14279277
121Recurrent sinusitis (HP:0011108)2.12114771
122Parakeratosis (HP:0001036)2.10668029
123Hepatosplenomegaly (HP:0001433)2.09560116
124Aplastic anemia (HP:0001915)2.09132153
125Infertility (HP:0000789)2.08937412
126Abnormality of chromosome segregation (HP:0002916)2.06156453
127Apathy (HP:0000741)2.03588688
128Encephalitis (HP:0002383)2.03363788
129Sloping forehead (HP:0000340)2.03358119
130Anorexia (HP:0002039)2.00081593
131Diminished motivation (HP:0000745)1.99952160
132Progressive neurologic deterioration (HP:0002344)1.99600651
133Ankle contracture (HP:0006466)1.99015178
134Hemorrhage of the eye (HP:0011885)1.95599146
135Abnormality of the duodenum (HP:0002246)1.94856203
136Medulloblastoma (HP:0002885)1.94322290
137Supernumerary spleens (HP:0009799)1.92541655
138Polygenic inheritance (HP:0010982)1.91917330
139Impulsivity (HP:0100710)1.91903393
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.91432761
141Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90560231
142Mutism (HP:0002300)1.90241612
143Restrictive lung disease (HP:0002091)1.89931206
144Metaphyseal irregularity (HP:0003025)1.89549639
145Chronic otitis media (HP:0000389)1.85817571
146Slender long bone (HP:0003100)1.85755292
147Thick nail (HP:0001805)1.85276947
148Bone marrow hypocellularity (HP:0005528)1.85147882
149Wrist flexion contracture (HP:0001239)1.84657726
150Spontaneous hematomas (HP:0007420)1.84615417
151Abnormal spermatogenesis (HP:0008669)1.84095932
152Slow saccadic eye movements (HP:0000514)1.83994037
153Arterial thrombosis (HP:0004420)1.83935992
154Thin bony cortex (HP:0002753)1.83857409
155Neoplasm of striated muscle (HP:0009728)1.82243612
156Hypertensive crisis (HP:0100735)1.81861432
157Episodic fever (HP:0001954)1.81854377
158Prominent nose (HP:0000448)1.81137699
159Polyneuropathy (HP:0001271)1.80718115
160Neoplasm of the oral cavity (HP:0100649)1.80188927
161Recurrent cutaneous fungal infections (HP:0011370)1.79350126
162Chronic mucocutaneous candidiasis (HP:0002728)1.79350126
163High pitched voice (HP:0001620)1.79299374
164Squamous cell carcinoma (HP:0002860)1.79277219
165Abnormal delayed hypersensitivity skin test (HP:0002963)1.78665293
166Absent/shortened dynein arms (HP:0200106)1.78092255
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.78092255
168Chronic bronchitis (HP:0004469)1.78039081
169Abnormality of transition element cation homeostasis (HP:0011030)1.78017930
170Abnormality of DNA repair (HP:0003254)1.77622243
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77465806
172Acne (HP:0001061)1.76781475
173Muscle fiber atrophy (HP:0100295)1.76450851
174Primary amenorrhea (HP:0000786)1.75356203
175Combined immunodeficiency (HP:0005387)1.75044572
176Long eyelashes (HP:0000527)1.73092107
177Blepharitis (HP:0000498)1.72949005
178Arterial tortuosity (HP:0005116)1.72669200
179Anomalous pulmonary venous return (HP:0010772)1.72021418
180Optic neuritis (HP:0100653)1.71062579
181Retrobulbar optic neuritis (HP:0100654)1.71062579
182Oligodactyly (hands) (HP:0001180)1.70206090
183Cystic hygroma (HP:0000476)1.68831271
184Pendular nystagmus (HP:0012043)1.67652155
185Type 2 muscle fiber atrophy (HP:0003554)1.66867009
186Absent hand (HP:0004050)1.65324883
187Azoospermia (HP:0000027)1.64772452
188Entropion (HP:0000621)1.63894141
189Cortical dysplasia (HP:0002539)1.63692292
190Duplicated collecting system (HP:0000081)1.63472017
191Hypoplastic iliac wings (HP:0002866)1.63031802
192Tracheoesophageal fistula (HP:0002575)1.62633604
193Aseptic necrosis (HP:0010885)1.58825592
194Abnormality of the epiphysis of the femoral head (HP:0010574)1.58681919
195Rough bone trabeculation (HP:0100670)1.58380090
196Absent thumb (HP:0009777)1.58285796
197Short 4th metacarpal (HP:0010044)1.56645889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.85652799
2ERN13.65282529
3EEF2K3.51751681
4PLK43.36098933
5MOS3.35568589
6NME23.33968543
7LATS13.31850488
8KSR23.27643360
9LATS23.18058922
10TTK2.98323579
11STK38L2.82028138
12MAP3K62.79003280
13TAOK32.77953485
14CDC72.63091904
15NEK22.60310697
16RIPK42.43622571
17TBK12.37751526
18TAOK12.37395296
19EPHA22.36987688
20MAP3K142.36482718
21BLK2.35240506
22BRAF2.34211239
23MAP3K132.33956600
24IRAK42.26767636
25MAP3K112.25884466
26RAF12.24864236
27MAPKAPK32.19392840
28BMPR22.15028673
29MAP3K32.14871545
30ERBB42.09739242
31TAOK22.09180013
32MUSK2.02411992
33MAP3K91.99415016
34STK101.93255974
35CSK1.90544373
36MATK1.90325204
37SMG11.87168077
38CDK91.86829688
39BUB11.86016813
40STK31.84196899
41PRPF4B1.75831720
42ARAF1.75412972
43RIPK11.74436712
44CDK81.74308221
45CDK121.73590517
46MAP2K31.71168779
47SIK11.70642102
48MST1R1.68355943
49IKBKE1.65469268
50EPHB11.59481323
51GRK71.56854478
52CDC42BPA1.56346293
53MELK1.54624902
54KSR11.51770905
55FGR1.43684517
56SIK31.43134536
57PLK11.41512904
58DYRK21.37191297
59ZAP701.37100133
60CHEK21.36160545
61DDR21.32611220
62PIM21.31029627
63NLK1.25131057
64TNK21.21183211
65ICK1.18313034
66MAP3K81.18143541
67ACVR1B1.18107701
68TGFBR21.12893600
69PAK61.09797724
70TXK1.06107802
71RPS6KA41.04297618
72JAK31.02601955
73CDK71.00858359
74AURKB1.00358948
75CDK40.98727538
76PRKD20.96343329
77RPS6KB20.95582332
78TYK20.89902696
79CSF1R0.88105244
80TESK10.86552961
81IRAK10.86539649
82BTK0.85100785
83PRKD30.82987094
84DYRK30.80466160
85LYN0.79455182
86IRAK20.79022111
87GRK60.74681140
88TRIB30.74492633
89PTK60.74307462
90WEE10.73298831
91SYK0.72147591
92SIK20.71575383
93HCK0.70888356
94EIF2AK10.69740353
95AURKA0.69404747
96BMX0.68338570
97EPHA30.66948630
98PRKAA20.63909450
99CHEK10.62857373
100ABL20.62072011
101MAPK110.61621425
102JAK10.61554494
103CHUK0.60127419
104LCK0.59504486
105ATR0.58853206
106MAP2K60.58192669
107MARK20.58109251
108PIM10.57933872
109STK380.55943319
110PDPK10.55823271
111MAP4K10.53103564
112PRKAA10.53066764
113BRSK20.52385982
114BRSK10.52048704
115MAP3K50.51789221
116TRPM70.51074447
117RPS6KC10.50615541
118RPS6KL10.50615541
119FGFR40.49689653
120MAPKAPK20.49184596
121KIT0.48950173
122PAK10.47651045
123ATM0.47465883
124MAPK150.47011868
125STK40.45558540
126MAPK70.44799377
127MAP3K100.44610446
128HIPK20.44437126
129STK240.43401435
130PDK10.41881357
131RPS6KA20.40076112
132NEK90.39890468
133FES0.39533355
134RPS6KA60.39397739
135CDK20.37936327
136RET0.37834439
137MTOR0.37801902
138PLK30.35981436
139ADRBK20.35630795
140LRRK20.33419928
141CSNK1G10.33197865
142TESK20.33176250
143DMPK0.32705888
144PRKG20.31462465
145CAMK1D0.29273518
146PAK40.28925432
147MAP2K20.28764435
148MAPKAPK50.28550860
149JAK20.28240130
150CDK10.27539667
151MAP2K10.25719073
152SRPK10.25292495
153MAP3K10.23947660
154PRKCI0.23726959
155IKBKB0.22487191
156TYRO30.21588942
157ABL10.19682366
158PKN20.18694673
159MAPK130.18378186
160MAPK10.18036226
161RPS6KA10.17533198
162CDK30.17527950
163MARK30.17104712
164VRK10.15375173

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.87552850
2RNA degradation_Homo sapiens_hsa030182.80538414
3Basal transcription factors_Homo sapiens_hsa030222.69691633
4DNA replication_Homo sapiens_hsa030302.64804243
5Vitamin B6 metabolism_Homo sapiens_hsa007502.46142544
6Staphylococcus aureus infection_Homo sapiens_hsa051502.45918475
7Base excision repair_Homo sapiens_hsa034102.41592822
8Allograft rejection_Homo sapiens_hsa053302.36058018
9RNA polymerase_Homo sapiens_hsa030202.22872372
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21666153
11RNA transport_Homo sapiens_hsa030132.15037177
12Lysosome_Homo sapiens_hsa041422.14165910
13p53 signaling pathway_Homo sapiens_hsa041152.11160360
14Graft-versus-host disease_Homo sapiens_hsa053322.10081304
15Fanconi anemia pathway_Homo sapiens_hsa034602.09213985
16Homologous recombination_Homo sapiens_hsa034402.08509913
17Ovarian steroidogenesis_Homo sapiens_hsa049132.07902725
18Tuberculosis_Homo sapiens_hsa051522.02395580
19Malaria_Homo sapiens_hsa051442.00370218
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.00221827
21Rheumatoid arthritis_Homo sapiens_hsa053231.96252064
22Mismatch repair_Homo sapiens_hsa034301.89707678
23Autoimmune thyroid disease_Homo sapiens_hsa053201.87518400
24Asthma_Homo sapiens_hsa053101.87473126
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86610670
26Pancreatic cancer_Homo sapiens_hsa052121.81096581
27Circadian rhythm_Homo sapiens_hsa047101.79512161
28Legionellosis_Homo sapiens_hsa051341.75069403
29Oocyte meiosis_Homo sapiens_hsa041141.70630446
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.69387836
31Pertussis_Homo sapiens_hsa051331.68988912
32Nucleotide excision repair_Homo sapiens_hsa034201.64351246
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59304789
34Hepatitis C_Homo sapiens_hsa051601.52957513
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.52020484
36Salmonella infection_Homo sapiens_hsa051321.51668888
37Non-homologous end-joining_Homo sapiens_hsa034501.51089808
38mRNA surveillance pathway_Homo sapiens_hsa030151.50796285
39TGF-beta signaling pathway_Homo sapiens_hsa043501.49505020
40African trypanosomiasis_Homo sapiens_hsa051431.46247059
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46165807
42MicroRNAs in cancer_Homo sapiens_hsa052061.45162302
43Linoleic acid metabolism_Homo sapiens_hsa005911.43349356
44Herpes simplex infection_Homo sapiens_hsa051681.43246664
45Type I diabetes mellitus_Homo sapiens_hsa049401.38791698
46Hematopoietic cell lineage_Homo sapiens_hsa046401.36484145
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30719777
48Colorectal cancer_Homo sapiens_hsa052101.28015867
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25873604
50Prolactin signaling pathway_Homo sapiens_hsa049171.24245885
51Small cell lung cancer_Homo sapiens_hsa052221.21913277
52Pyrimidine metabolism_Homo sapiens_hsa002401.21227774
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19465829
54Chronic myeloid leukemia_Homo sapiens_hsa052201.19256244
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16566331
56Spliceosome_Homo sapiens_hsa030401.15574400
57Chemokine signaling pathway_Homo sapiens_hsa040621.14504088
58Phagosome_Homo sapiens_hsa041451.11175867
59Epstein-Barr virus infection_Homo sapiens_hsa051691.07543745
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07456977
61Adherens junction_Homo sapiens_hsa045201.06497375
62Hepatitis B_Homo sapiens_hsa051611.06264537
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04408855
64HTLV-I infection_Homo sapiens_hsa051661.03995731
65NF-kappa B signaling pathway_Homo sapiens_hsa040641.03528364
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01160412
67VEGF signaling pathway_Homo sapiens_hsa043700.99011747
68One carbon pool by folate_Homo sapiens_hsa006700.98309650
69Ether lipid metabolism_Homo sapiens_hsa005650.95022710
70T cell receptor signaling pathway_Homo sapiens_hsa046600.94456184
71Hippo signaling pathway_Homo sapiens_hsa043900.92638005
72Thyroid cancer_Homo sapiens_hsa052160.92403704
73Folate biosynthesis_Homo sapiens_hsa007900.90498189
74Fructose and mannose metabolism_Homo sapiens_hsa000510.90441521
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89825258
76Shigellosis_Homo sapiens_hsa051310.88797010
77Amoebiasis_Homo sapiens_hsa051460.88689391
78Acute myeloid leukemia_Homo sapiens_hsa052210.88666466
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88211152
80Apoptosis_Homo sapiens_hsa042100.88035479
81FoxO signaling pathway_Homo sapiens_hsa040680.87700116
82Influenza A_Homo sapiens_hsa051640.86755477
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85502573
84Renal cell carcinoma_Homo sapiens_hsa052110.85396529
85Dorso-ventral axis formation_Homo sapiens_hsa043200.85197662
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.84873498
87mTOR signaling pathway_Homo sapiens_hsa041500.83995370
88Choline metabolism in cancer_Homo sapiens_hsa052310.83400692
89Sphingolipid metabolism_Homo sapiens_hsa006000.83398142
90Bladder cancer_Homo sapiens_hsa052190.81698607
91Viral carcinogenesis_Homo sapiens_hsa052030.80196194
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.79834284
93Endometrial cancer_Homo sapiens_hsa052130.79413024
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.77447105
95Measles_Homo sapiens_hsa051620.77240799
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77000638
97Galactose metabolism_Homo sapiens_hsa000520.76233457
98Prostate cancer_Homo sapiens_hsa052150.74027535
99TNF signaling pathway_Homo sapiens_hsa046680.72239572
100Non-small cell lung cancer_Homo sapiens_hsa052230.71407466
101Prion diseases_Homo sapiens_hsa050200.69797444
102Toxoplasmosis_Homo sapiens_hsa051450.69638688
103B cell receptor signaling pathway_Homo sapiens_hsa046620.68917160
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.65343002
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62892189
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.61868519
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.61673369
108Leishmaniasis_Homo sapiens_hsa051400.60500439
109Purine metabolism_Homo sapiens_hsa002300.60381057
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.59428681
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59370895
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59241455
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58842352
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58539891
115GnRH signaling pathway_Homo sapiens_hsa049120.56611867
116Endocytosis_Homo sapiens_hsa041440.53915875
117Other glycan degradation_Homo sapiens_hsa005110.53104610
118Pathways in cancer_Homo sapiens_hsa052000.52482748
119Insulin resistance_Homo sapiens_hsa049310.49046640
120Primary immunodeficiency_Homo sapiens_hsa053400.46867298
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.46411019
122Antigen processing and presentation_Homo sapiens_hsa046120.45768649
123Osteoclast differentiation_Homo sapiens_hsa043800.45530077
124Basal cell carcinoma_Homo sapiens_hsa052170.45474524
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45222295
126* Notch signaling pathway_Homo sapiens_hsa043300.44451907
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43798543
128Melanoma_Homo sapiens_hsa052180.42827481
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42774144
130Hedgehog signaling pathway_Homo sapiens_hsa043400.41866199
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39763806
132Collecting duct acid secretion_Homo sapiens_hsa049660.38917764
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.38771346
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38770473
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38751278
136Pentose phosphate pathway_Homo sapiens_hsa000300.37850890
137Arachidonic acid metabolism_Homo sapiens_hsa005900.37777105
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37475977
139Viral myocarditis_Homo sapiens_hsa054160.36600262
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36457650
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36376575
142Inositol phosphate metabolism_Homo sapiens_hsa005620.35815258
143MAPK signaling pathway_Homo sapiens_hsa040100.35711331
144HIF-1 signaling pathway_Homo sapiens_hsa040660.35664104
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35562957
146Ras signaling pathway_Homo sapiens_hsa040140.34472445
147Complement and coagulation cascades_Homo sapiens_hsa046100.34438217
148Glutathione metabolism_Homo sapiens_hsa004800.33769849
149Vibrio cholerae infection_Homo sapiens_hsa051100.33222388
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.30535541
151Mineral absorption_Homo sapiens_hsa049780.29870023
152Platelet activation_Homo sapiens_hsa046110.25627512
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23600523
154Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21275414
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.20115854
156Sulfur relay system_Homo sapiens_hsa041220.19938888

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »