DTX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.07851892
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67629587
3locomotory exploration behavior (GO:0035641)5.55248342
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45244841
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.99350537
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.78964968
7synaptic vesicle exocytosis (GO:0016079)4.55988479
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.52960681
9regulation of synapse structural plasticity (GO:0051823)4.51728748
10vocalization behavior (GO:0071625)4.33092039
11regulation of synaptic vesicle exocytosis (GO:2000300)4.32559584
12layer formation in cerebral cortex (GO:0021819)4.27420430
13establishment of mitochondrion localization (GO:0051654)4.26123770
14glutamate secretion (GO:0014047)4.25037629
15regulation of glutamate receptor signaling pathway (GO:1900449)4.24967629
16sodium ion export (GO:0071436)4.24963403
17regulation of neuronal synaptic plasticity (GO:0048168)4.09815618
18axon ensheathment in central nervous system (GO:0032291)4.05473353
19central nervous system myelination (GO:0022010)4.05473353
20cerebellar granule cell differentiation (GO:0021707)4.05216006
21neurotransmitter secretion (GO:0007269)3.94357971
22exploration behavior (GO:0035640)3.90737875
23regulation of synaptic vesicle transport (GO:1902803)3.88027453
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.86274139
25mitochondrion transport along microtubule (GO:0047497)3.81942527
26establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.81942527
27cellular potassium ion homeostasis (GO:0030007)3.79402122
28dendritic spine morphogenesis (GO:0060997)3.76908039
29protein localization to synapse (GO:0035418)3.76279257
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75723341
31positive regulation of synapse maturation (GO:0090129)3.73241664
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.72244048
33pyrimidine nucleobase catabolic process (GO:0006208)3.70819431
34cell communication by electrical coupling (GO:0010644)3.65960844
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.65856930
36activation of protein kinase A activity (GO:0034199)3.65247362
37neuronal action potential propagation (GO:0019227)3.56037918
38neuromuscular process controlling balance (GO:0050885)3.55240000
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55147622
40presynaptic membrane organization (GO:0097090)3.54241208
41gamma-aminobutyric acid transport (GO:0015812)3.47891078
42presynaptic membrane assembly (GO:0097105)3.45842479
43synaptic transmission, glutamatergic (GO:0035249)3.43074960
44cerebellar Purkinje cell differentiation (GO:0021702)3.39958876
45long-term memory (GO:0007616)3.34207472
46auditory behavior (GO:0031223)3.27452355
47L-amino acid import (GO:0043092)3.25335115
48neuronal ion channel clustering (GO:0045161)3.24117539
49proline transport (GO:0015824)3.23162198
50glycine transport (GO:0015816)3.22715434
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21126248
52positive regulation of membrane potential (GO:0045838)3.20770512
53transmission of nerve impulse (GO:0019226)3.19072128
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18407011
55neurotransmitter-gated ion channel clustering (GO:0072578)3.18033675
56regulation of voltage-gated calcium channel activity (GO:1901385)3.17501427
57establishment of nucleus localization (GO:0040023)3.15296750
58regulation of ARF protein signal transduction (GO:0032012)3.13888460
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13871837
60negative regulation of catenin import into nucleus (GO:0035414)3.13238866
61membrane depolarization during action potential (GO:0086010)3.11207587
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10559526
63positive regulation of dendritic spine development (GO:0060999)3.09781981
64amino acid import (GO:0043090)3.09360429
65axon extension (GO:0048675)3.06243015
66regulation of synaptic plasticity (GO:0048167)3.06053310
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05828161
68response to pheromone (GO:0019236)3.05645052
69prepulse inhibition (GO:0060134)3.05271926
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04865879
71cell migration in hindbrain (GO:0021535)3.03952439
72potassium ion import (GO:0010107)3.03861012
73neuron-neuron synaptic transmission (GO:0007270)3.03718890
74glutamate receptor signaling pathway (GO:0007215)3.03172227
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02843436
76response to auditory stimulus (GO:0010996)3.02293747
77mechanosensory behavior (GO:0007638)3.01988411
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99542685
79regulation of postsynaptic membrane potential (GO:0060078)2.96460437
80synaptic vesicle endocytosis (GO:0048488)2.96259018
81neurotransmitter transport (GO:0006836)2.96044347
82potassium ion homeostasis (GO:0055075)2.95089974
83dendrite morphogenesis (GO:0048813)2.95023211
84positive regulation of neurotransmitter transport (GO:0051590)2.94345663
85neuromuscular process controlling posture (GO:0050884)2.93899645
86positive regulation of synapse assembly (GO:0051965)2.93453403
87axonal fasciculation (GO:0007413)2.93387629
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93287473
89peptidyl-tyrosine autophosphorylation (GO:0038083)2.91918342
90positive regulation of neurotransmitter secretion (GO:0001956)2.91026913
91regulation of neurotransmitter secretion (GO:0046928)2.90517873
92nucleobase catabolic process (GO:0046113)2.87556461
93neuron cell-cell adhesion (GO:0007158)2.85931467
94innervation (GO:0060384)2.85427910
95cerebellar Purkinje cell layer development (GO:0021680)2.85255597
96regulation of dendritic spine morphogenesis (GO:0061001)2.84307770
97dendritic spine organization (GO:0097061)2.84108208
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.83847392
99dopamine receptor signaling pathway (GO:0007212)2.81654780
100cell differentiation in hindbrain (GO:0021533)2.81266933
101synapse assembly (GO:0007416)2.81014448
102negative regulation of axonogenesis (GO:0050771)2.80829199
103regulation of vesicle fusion (GO:0031338)2.80275626
104neuron recognition (GO:0008038)2.79009047
105regulation of neurotransmitter levels (GO:0001505)2.77855592
106cellular sodium ion homeostasis (GO:0006883)2.76715867
107negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73392760
108membrane depolarization (GO:0051899)2.73233263
109regulation of neurotransmitter transport (GO:0051588)2.72711114
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71796069
111neuromuscular synaptic transmission (GO:0007274)2.71436247
112neuromuscular process (GO:0050905)2.70477011
113neuron projection extension (GO:1990138)2.70360926
114positive regulation of dendritic spine morphogenesis (GO:0061003)2.70026764
115membrane repolarization (GO:0086009)2.69693720
116synapse organization (GO:0050808)2.64610266
117long-term synaptic potentiation (GO:0060291)2.63437072
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.63272378
119regulation of ARF GTPase activity (GO:0032312)2.61771876
120regulation of synapse maturation (GO:0090128)2.61194979
121membrane hyperpolarization (GO:0060081)2.60757508
122postsynaptic membrane organization (GO:0001941)2.57926434
123vesicle transport along microtubule (GO:0047496)2.57841976
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.57423039
125regulation of clathrin-mediated endocytosis (GO:2000369)2.57415405
126regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.57258553
127negative regulation of microtubule polymerization (GO:0031115)2.56783807
128positive regulation of synaptic transmission (GO:0050806)2.56652369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08818558
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36844452
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.10026532
4* RARB_27405468_Chip-Seq_BRAIN_Mouse2.96363164
5DROSHA_22980978_ChIP-Seq_HELA_Human2.83833374
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.80909784
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70896794
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70896794
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69902063
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68741251
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66876815
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62276532
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.59283077
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43086879
15REST_21632747_ChIP-Seq_MESCs_Mouse2.38873644
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37744089
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36362679
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36110360
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34616568
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.33825825
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.32749663
22ZFP281_18757296_ChIP-ChIP_E14_Mouse2.32494699
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24898636
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.23766872
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19066282
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.15107996
27KDM2B_26808549_Chip-Seq_K562_Human2.05670436
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.01377384
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.99694478
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.98617929
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96844255
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89659428
33EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.82662580
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80068304
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79523924
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75238804
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67433955
38LXR_22292898_ChIP-Seq_THP-1_Human1.65876161
39KDM2B_26808549_Chip-Seq_DND41_Human1.65518446
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.62219297
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60285544
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59625567
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.58702569
44* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57733411
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56100688
46GBX2_23144817_ChIP-Seq_PC3_Human1.50649302
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50306733
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44157462
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42705265
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.41557352
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37800496
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35229957
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35114517
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.33651966
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30958788
56CTCF_27219007_Chip-Seq_Bcells_Human1.26946308
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22550638
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21000231
59SMC4_20622854_ChIP-Seq_HELA_Human1.19086603
60RNF2_27304074_Chip-Seq_NSC_Mouse1.18411237
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.16726175
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16390177
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.16026569
64* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15943244
65* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15135909
66AR_19668381_ChIP-Seq_PC3_Human1.13079585
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12482832
68TCF7_22412390_ChIP-Seq_EML_Mouse1.10681610
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09971132
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09256051
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08776610
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.08384751
73CREB1_26743006_Chip-Seq_LNCaP_Human1.08220203
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08030241
75* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07831250
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06906790
77AR_21572438_ChIP-Seq_LNCaP_Human1.04523274
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01971278
79ZNF274_21170338_ChIP-Seq_K562_Hela1.01717566
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99974117
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96064082
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95854478
83TRIM28_21343339_ChIP-Seq_HEK293_Human0.95240390
84MYC_22102868_ChIP-Seq_BL_Human0.95220696
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93835178
86SOX3_22085726_ChIP-Seq_NPCs_Mouse0.93782795
87P68_20966046_ChIP-Seq_HELA_Human0.92614779
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91878946
89SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90681925
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90627534
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90264259
92KLF4_19829295_ChIP-Seq_ESCs_Human0.89647426
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.89633118
94MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89406363
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87170397
96OCT4_19829295_ChIP-Seq_ESCs_Human0.86922394
97NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86284627
98TP53_23651856_ChIP-Seq_MEFs_Mouse0.86281019
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85664408
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.85483277
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85426809
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84821421
103* ISL1_27105846_Chip-Seq_CPCs_Mouse0.84564418
104MYC_27129775_Chip-Seq_CORNEA_Mouse0.84394602
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83375759
106SA1_27219007_Chip-Seq_ERYTHROID_Human0.79244464
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.78709497
108SA1_27219007_Chip-Seq_Bcells_Human0.78678054
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.78586046
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.77974718
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77907912
112POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77147034
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76555055
114SMAD4_21741376_ChIP-Seq_ESCs_Human0.75909671
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.75889802
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75600352
117* RACK7_27058665_Chip-Seq_MCF-7_Human0.75052902
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74129530
119DPY_21335234_ChIP-Seq_ESCs_Mouse0.73720322
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.73642635
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73282174
122TP63_22573176_ChIP-Seq_HFKS_Human0.73034239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.40582863
2MP0003635_abnormal_synaptic_transmissio3.72397491
3MP0003880_abnormal_central_pattern3.07063073
4MP0004270_analgesia2.94078312
5MP0005423_abnormal_somatic_nervous2.94025803
6MP0002063_abnormal_learning/memory/cond2.85902848
7MP0002822_catalepsy2.79454531
8MP0009745_abnormal_behavioral_response2.71279386
9MP0002064_seizures2.57893577
10MP0009046_muscle_twitch2.52835969
11MP0002909_abnormal_adrenal_gland2.42751528
12MP0008569_lethality_at_weaning2.23268856
13MP0002572_abnormal_emotion/affect_behav2.23187825
14MP0003283_abnormal_digestive_organ2.21201942
15MP0004858_abnormal_nervous_system2.13482568
16MP0009780_abnormal_chondrocyte_physiolo2.09563817
17MP0002272_abnormal_nervous_system2.06095676
18MP0003123_paternal_imprinting2.04357199
19MP0008961_abnormal_basal_metabolism2.02013831
20MP0003122_maternal_imprinting1.96506429
21MP0001968_abnormal_touch/_nociception1.93694500
22MP0002734_abnormal_mechanical_nocicepti1.93230882
23MP0001486_abnormal_startle_reflex1.92144496
24MP0004811_abnormal_neuron_physiology1.83090883
25MP0002653_abnormal_ependyma_morphology1.73119820
26MP0004885_abnormal_endolymph1.72888086
27MP0000751_myopathy1.70273828
28MP0002184_abnormal_innervation1.70115741
29MP0000955_abnormal_spinal_cord1.66255531
30MP0001501_abnormal_sleep_pattern1.66040993
31MP0002733_abnormal_thermal_nociception1.64367829
32MP0000566_synostosis1.62555464
33MP0000778_abnormal_nervous_system1.59617664
34MP0001970_abnormal_pain_threshold1.55390221
35MP0002557_abnormal_social/conspecific_i1.54889237
36MP0003787_abnormal_imprinting1.53405663
37MP0001502_abnormal_circadian_rhythm1.52994873
38MP0002067_abnormal_sensory_capabilities1.48588741
39MP0000569_abnormal_digit_pigmentation1.47932237
40MP0000013_abnormal_adipose_tissue1.47187811
41MP0002882_abnormal_neuron_morphology1.38843695
42MP0005646_abnormal_pituitary_gland1.37878400
43MP0002234_abnormal_pharynx_morphology1.37752047
44MP0003879_abnormal_hair_cell1.37381816
45MP0004145_abnormal_muscle_electrophysio1.35309537
46MP0001440_abnormal_grooming_behavior1.34889370
47MP0009379_abnormal_foot_pigmentation1.32396790
48MP0002249_abnormal_larynx_morphology1.31721609
49MP0003329_amyloid_beta_deposits1.29234154
50MP0005645_abnormal_hypothalamus_physiol1.29196573
51MP0004233_abnormal_muscle_weight1.27809420
52MP0001984_abnormal_olfaction1.25930328
53MP0002736_abnormal_nociception_after1.25127813
54MP0004924_abnormal_behavior1.24888349
55MP0005386_behavior/neurological_phenoty1.24888349
56MP0002735_abnormal_chemical_nociception1.24781386
57MP0004133_heterotaxia1.22901735
58MP0002066_abnormal_motor_capabilities/c1.20795063
59MP0001188_hyperpigmentation1.18563615
60MP0001529_abnormal_vocalization1.16953593
61MP0002152_abnormal_brain_morphology1.14123964
62MP0003633_abnormal_nervous_system1.14026819
63MP0003172_abnormal_lysosome_physiology1.13055436
64MP0006292_abnormal_olfactory_placode1.12441964
65MP0001905_abnormal_dopamine_level1.09218787
66MP0003938_abnormal_ear_development1.07163146
67MP0006072_abnormal_retinal_apoptosis1.05807965
68MP0003690_abnormal_glial_cell1.05186597
69MP0002089_abnormal_postnatal_growth/wei1.04684416
70MP0001963_abnormal_hearing_physiology1.03434067
71MP0004742_abnormal_vestibular_system1.02778196
72MP0000049_abnormal_middle_ear1.02687785
73MP0000534_abnormal_ureter_morphology1.02539654
74MP0008789_abnormal_olfactory_epithelium1.02421900
75MP0000026_abnormal_inner_ear1.02088488
76MP0005499_abnormal_olfactory_system0.99317332
77MP0005394_taste/olfaction_phenotype0.99317332
78MP0005623_abnormal_meninges_morphology0.98517444
79MP0000920_abnormal_myelination0.97842542
80MP0001485_abnormal_pinna_reflex0.96470812
81MP0001177_atelectasis0.95141595
82MP0003137_abnormal_impulse_conducting0.93637121
83MP0000631_abnormal_neuroendocrine_gland0.93087881
84MP0003942_abnormal_urinary_system0.92827043
85MP0004085_abnormal_heartbeat0.91789212
86MP0000003_abnormal_adipose_tissue0.91786848
87MP0002069_abnormal_eating/drinking_beha0.89145293
88MP0001346_abnormal_lacrimal_gland0.87295923
89MP0003075_altered_response_to0.84650002
90MP0001299_abnormal_eye_distance/0.84324440
91MP0004215_abnormal_myocardial_fiber0.84143699
92MP0003136_yellow_coat_color0.82652101
93MP0003119_abnormal_digestive_system0.81461623
94MP0003631_nervous_system_phenotype0.81414681
95MP0005409_darkened_coat_color0.81066708
96MP0005377_hearing/vestibular/ear_phenot0.80414727
97MP0003878_abnormal_ear_physiology0.80414727
98MP0003632_abnormal_nervous_system0.79340845
99MP0004142_abnormal_muscle_tone0.78829617
100MP0002837_dystrophic_cardiac_calcinosis0.78173648
101MP0010030_abnormal_orbit_morphology0.78114196
102MP0003634_abnormal_glial_cell0.77251114
103MP0003183_abnormal_peptide_metabolism0.77034893
104MP0005551_abnormal_eye_electrophysiolog0.76900832
105MP0003861_abnormal_nervous_system0.76528963
106MP0002116_abnormal_craniofacial_bone0.74578035
107MP0000579_abnormal_nail_morphology0.73662950
108MP0001348_abnormal_lacrimal_gland0.72553692
109MP0010386_abnormal_urinary_bladder0.71755696
110MP0004043_abnormal_pH_regulation0.71624176
111MP0000537_abnormal_urethra_morphology0.71350136
112MP0002229_neurodegeneration0.71105025
113MP0002752_abnormal_somatic_nervous0.70406145
114MP0005167_abnormal_blood-brain_barrier0.69733528
115MP0008874_decreased_physiological_sensi0.69291590
116MP0004084_abnormal_cardiac_muscle0.68945681
117MP0002638_abnormal_pupillary_reflex0.68279377
118MP0003121_genomic_imprinting0.67961370
119MP0002081_perinatal_lethality0.67429810
120MP0005187_abnormal_penis_morphology0.66363908
121MP0004510_myositis0.65429346
122MP0004130_abnormal_muscle_cell0.65055201
123MP0008872_abnormal_physiological_respon0.65020033
124MP0010769_abnormal_survival0.64331010
125MP0005253_abnormal_eye_physiology0.62601960
126MP0000678_abnormal_parathyroid_gland0.61494906
127MP0001270_distended_abdomen0.60854520
128MP0010768_mortality/aging0.60258871
129MP0006276_abnormal_autonomic_nervous0.59919853
130MP0001943_abnormal_respiration0.59516735
131MP0010770_preweaning_lethality0.59397464

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.11617196
2Focal motor seizures (HP:0011153)4.53114478
3Visual hallucinations (HP:0002367)4.21449356
4Focal seizures (HP:0007359)4.08700357
5Hyperacusis (HP:0010780)3.55538869
6Insomnia (HP:0100785)3.39594108
7Sleep apnea (HP:0010535)3.32234012
8Epileptic encephalopathy (HP:0200134)3.31560996
9Neurofibrillary tangles (HP:0002185)3.25582859
10Depression (HP:0000716)3.20743091
11Ankle clonus (HP:0011448)3.19526489
12Supranuclear gaze palsy (HP:0000605)3.11235151
13Action tremor (HP:0002345)3.04836633
14Abnormality of the lower motor neuron (HP:0002366)2.99460239
15Pointed chin (HP:0000307)2.98954634
16Annular pancreas (HP:0001734)2.91861431
17Neoplasm of the heart (HP:0100544)2.86171373
18Progressive cerebellar ataxia (HP:0002073)2.83495391
19Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.77292236
20Turricephaly (HP:0000262)2.74762555
21Poor eye contact (HP:0000817)2.72975788
22Febrile seizures (HP:0002373)2.72478948
23Elfin facies (HP:0004428)2.69030220
24Hemiplegia (HP:0002301)2.65767475
25Polyphagia (HP:0002591)2.63057785
26Atonic seizures (HP:0010819)2.59736254
27Hemiparesis (HP:0001269)2.58520115
28Abnormal social behavior (HP:0012433)2.54537109
29Impaired social interactions (HP:0000735)2.54537109
30Renal duplication (HP:0000075)2.51093610
31Truncal ataxia (HP:0002078)2.47111422
32Ventricular fibrillation (HP:0001663)2.46156111
33Cerebral inclusion bodies (HP:0100314)2.44860332
34Torticollis (HP:0000473)2.44822783
35Abnormality of the aortic arch (HP:0012303)2.43995027
36Postural instability (HP:0002172)2.43094075
37Genetic anticipation (HP:0003743)2.41637021
38Abnormality of the corticospinal tract (HP:0002492)2.40909746
39Fetal akinesia sequence (HP:0001989)2.39847820
40Anxiety (HP:0000739)2.39339134
41Absence seizures (HP:0002121)2.37953469
42Impaired smooth pursuit (HP:0007772)2.35760376
43Broad-based gait (HP:0002136)2.35228217
44Hypoventilation (HP:0002791)2.34821507
45Dysdiadochokinesis (HP:0002075)2.34335391
46Impaired vibration sensation in the lower limbs (HP:0002166)2.32585440
47Generalized tonic-clonic seizures (HP:0002069)2.31606384
48Overriding aorta (HP:0002623)2.29778347
49Bronchomalacia (HP:0002780)2.28956531
50Spinal canal stenosis (HP:0003416)2.26428283
51Hypercortisolism (HP:0001578)2.26249063
52Focal dystonia (HP:0004373)2.26209535
53Dysmetric saccades (HP:0000641)2.26049259
54Macroorchidism (HP:0000053)2.25135781
55Papilledema (HP:0001085)2.23322720
56Stereotypic behavior (HP:0000733)2.22411481
57Peripheral hypomyelination (HP:0007182)2.22207563
58Megalencephaly (HP:0001355)2.20503872
59Abnormal eating behavior (HP:0100738)2.17881889
60Epileptiform EEG discharges (HP:0011182)2.15438842
61Gaze-evoked nystagmus (HP:0000640)2.14291172
62Abnormality of binocular vision (HP:0011514)2.13772951
63Diplopia (HP:0000651)2.13772951
64Renovascular hypertension (HP:0100817)2.12083756
65Bundle branch block (HP:0011710)2.11794913
66Abnormality of ocular smooth pursuit (HP:0000617)2.11095014
67Akinesia (HP:0002304)2.10361967
68Dialeptic seizures (HP:0011146)2.09209247
69Flat cornea (HP:0007720)2.07830811
70Failure to thrive in infancy (HP:0001531)2.07362243
71Distal upper limb amyotrophy (HP:0007149)2.06891772
72Upper limb amyotrophy (HP:0009129)2.06891772
73Amblyopia (HP:0000646)2.06008310
74Urinary bladder sphincter dysfunction (HP:0002839)2.05614747
75Aplasia involving bones of the extremities (HP:0009825)2.05538267
76Aplasia involving bones of the upper limbs (HP:0009823)2.05538267
77Aplasia of the phalanges of the hand (HP:0009802)2.05538267
78Status epilepticus (HP:0002133)2.03636901
79Drooling (HP:0002307)2.03223145
80EEG with generalized epileptiform discharges (HP:0011198)2.01352963
81Urinary urgency (HP:0000012)1.98434955
82Hyperthyroidism (HP:0000836)1.97891555
83Craniofacial dystonia (HP:0012179)1.97414345
84Broad metatarsal (HP:0001783)1.97413986
85Bradykinesia (HP:0002067)1.96225125
86Abnormal EKG (HP:0003115)1.95352647
87Cerebral aneurysm (HP:0004944)1.94856882
88Hypsarrhythmia (HP:0002521)1.94821552
89Bowel diverticulosis (HP:0005222)1.94461533
90Dysmetria (HP:0001310)1.94320780
91Agitation (HP:0000713)1.93421463
92Excessive salivation (HP:0003781)1.91717467
93Mutism (HP:0002300)1.89434095
94Enlarged penis (HP:0000040)1.88692622
95Gait imbalance (HP:0002141)1.88246132
96Prolonged QT interval (HP:0001657)1.87641840
97Cerebral hypomyelination (HP:0006808)1.85977473
98Abnormal respiratory motile cilium morphology (HP:0005938)1.84232691
99Abnormal respiratory epithelium morphology (HP:0012253)1.84232691
100Ankyloglossia (HP:0010296)1.84142151
101Lower limb amyotrophy (HP:0007210)1.83712761
102Obsessive-compulsive behavior (HP:0000722)1.83519927
103Anomalous pulmonary venous return (HP:0010772)1.83244804
104Abnormal hair whorl (HP:0010721)1.82302969
105Generalized hypotonia (HP:0001290)1.81314630
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80968412
107Abnormality of the diencephalon (HP:0010662)1.80435741
108Spastic gait (HP:0002064)1.79478996
109Atelectasis (HP:0100750)1.75359921
110Poor suck (HP:0002033)1.75053091
111Narrow nasal bridge (HP:0000446)1.74848611
112Bladder diverticulum (HP:0000015)1.74781843
113Deep palmar crease (HP:0006191)1.73580604
114Hepatoblastoma (HP:0002884)1.73467770
115Resting tremor (HP:0002322)1.72872592
116Rapidly progressive (HP:0003678)1.72736061
117Lower limb asymmetry (HP:0100559)1.71912781
118Hypoplasia of the corpus callosum (HP:0002079)1.71357771
119Shallow orbits (HP:0000586)1.70775004
120Obstructive sleep apnea (HP:0002870)1.70301427
121Intention tremor (HP:0002080)1.69580475
122Hand muscle atrophy (HP:0009130)1.69562464
123Spastic tetraplegia (HP:0002510)1.67236319
124Limb dystonia (HP:0002451)1.67072795
125Truncus arteriosus (HP:0001660)1.66340906
126Vitreoretinal degeneration (HP:0000655)1.65776580
127Trigonocephaly (HP:0000243)1.65774352
128Clonus (HP:0002169)1.64120049
129Neuronal loss in central nervous system (HP:0002529)1.64077515
130Sacral dimple (HP:0000960)1.63724232
131Increased variability in muscle fiber diameter (HP:0003557)1.62690124
132Apathy (HP:0000741)1.62559812
133Lower limb muscle weakness (HP:0007340)1.62532713
134Septo-optic dysplasia (HP:0100842)1.61753265
135Central scotoma (HP:0000603)1.60078799
136Menstrual irregularities (HP:0000858)1.59831291
137Large eyes (HP:0001090)1.58922309
138Abnormality of oral frenula (HP:0000190)1.57471798
139Striae distensae (HP:0001065)1.57279579
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55837442
141Scanning speech (HP:0002168)1.55039160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.65265156
2MAP3K93.54005485
3EPHA43.43858354
4PRKD32.95958206
5DAPK22.38542441
6CASK2.33627702
7PAK62.29805622
8MARK12.24834209
9KSR22.18176338
10MINK12.17463720
11TRIB32.16557662
12CAMKK12.12998101
13NTRK22.09185710
14MAP3K41.95793545
15RIPK11.95496959
16SIK21.89691097
17KSR11.76297845
18NTRK11.65752656
19UHMK11.62483303
20TYRO31.61679898
21TNIK1.56737594
22STK381.55489991
23DAPK11.54604823
24DYRK21.52803088
25TAOK11.42855835
26ICK1.41693080
27CDK51.41193512
28PKN21.36956253
29PDGFRA1.30060278
30CDK191.29194324
31MARK21.23024884
32CAMK11.21093105
33PRKCH1.20545346
34PHKG11.19448021
35PHKG21.19448021
36DDR21.19366724
37CAMKK21.18969577
38EEF2K1.17913524
39MAP2K71.15373463
40MAP3K131.13164820
41PRPF4B1.12254265
42FGFR21.11658401
43MAP2K41.10697778
44LMTK21.10582596
45ALK1.07964677
46RET1.06573568
47SIK11.04845688
48CAMK1G1.04825161
49CDC42BPA1.01321484
50PKN10.98664563
51RIPK40.98360807
52MAP3K70.97595949
53MAP3K20.96937766
54FES0.91347477
55NEK10.88329074
56CAMK2B0.85565130
57CAMK40.83019711
58PINK10.82272551
59MAPK130.81277816
60GRK50.80209692
61PRKCG0.79510556
62CDK180.78009448
63CDK150.77934090
64PAK30.77325299
65MAPK120.76063241
66PRKD20.74267638
67BRAF0.73637906
68MAP3K120.73018298
69CDK11A0.71678174
70SGK30.70961288
71CAMK2G0.70699489
72CSNK1G20.70106723
73STK110.69951082
74RAF10.69781427
75DMPK0.69542587
76HIPK20.69364905
77SCYL20.68854844
78FGFR40.68253489
79PTK2B0.67845877
80SGK4940.67362488
81SGK2230.67362488
82SMG10.67209145
83CDK140.66890069
84RPS6KA20.66315097
85MAP3K10.65623515
86TNK20.64658353
87MAP3K100.62902383
88PNCK0.61064205
89ROCK20.60455897
90MAP3K110.59580861
91SGK10.55838975
92LIMK10.55265940
93WNK10.55154054
94ERBB20.54933987
95NEK60.53987702
96PTK20.53667989
97BMX0.51997990
98TTN0.51147619
99PDK10.50951626
100WNK30.50825583
101DYRK1A0.50777351
102TESK10.50368313
103SGK20.50072576
104DAPK30.49853847
105RPS6KA30.49736548
106CAMK1D0.49725963
107SIK30.48947371
108EPHB20.48486290
109ARAF0.48108916
110DYRK1B0.47996957
111PLK20.47629160
112MUSK0.47121753
113LATS20.47070038
114FYN0.46479038
115MAPK100.46067971
116PTK60.45976065
117MAPK150.45440889
118PDPK10.44594002
119MAPK80.42839657
120RPS6KC10.42395699
121RPS6KL10.42395699
122BRSK10.42168562
123PRKCZ0.40932960
124PRKAA10.40179715
125MTOR0.39586773
126CAMK2A0.39548717

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.73842612
2Olfactory transduction_Homo sapiens_hsa047402.51950934
3Circadian entrainment_Homo sapiens_hsa047132.45452925
4Nicotine addiction_Homo sapiens_hsa050332.42820052
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25263896
6GABAergic synapse_Homo sapiens_hsa047272.25195754
7Long-term potentiation_Homo sapiens_hsa047202.18609795
8Glutamatergic synapse_Homo sapiens_hsa047242.10249743
9Morphine addiction_Homo sapiens_hsa050322.06305337
10Amphetamine addiction_Homo sapiens_hsa050312.04581593
11Insulin secretion_Homo sapiens_hsa049111.98463516
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96826357
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90929219
14Dopaminergic synapse_Homo sapiens_hsa047281.88183515
15Gastric acid secretion_Homo sapiens_hsa049711.78257499
16Salivary secretion_Homo sapiens_hsa049701.77237227
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73259587
18Cholinergic synapse_Homo sapiens_hsa047251.72642876
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64221089
20Cocaine addiction_Homo sapiens_hsa050301.62540309
21Oxytocin signaling pathway_Homo sapiens_hsa049211.57770703
22Renin secretion_Homo sapiens_hsa049241.41079851
23GnRH signaling pathway_Homo sapiens_hsa049121.40820304
24Type II diabetes mellitus_Homo sapiens_hsa049301.37522758
25Calcium signaling pathway_Homo sapiens_hsa040201.34011577
26Gap junction_Homo sapiens_hsa045401.33449990
27Taste transduction_Homo sapiens_hsa047421.32026283
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30575189
29Long-term depression_Homo sapiens_hsa047301.29335294
30cAMP signaling pathway_Homo sapiens_hsa040241.28066725
31Estrogen signaling pathway_Homo sapiens_hsa049151.23127323
32Glioma_Homo sapiens_hsa052141.22207361
33* Notch signaling pathway_Homo sapiens_hsa043301.15493031
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14967055
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13572927
36Melanogenesis_Homo sapiens_hsa049161.13190623
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10653630
38Dilated cardiomyopathy_Homo sapiens_hsa054141.09658050
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08376235
40Serotonergic synapse_Homo sapiens_hsa047261.07302185
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06123703
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.02432084
43Axon guidance_Homo sapiens_hsa043601.01651355
44ErbB signaling pathway_Homo sapiens_hsa040121.00994792
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00798049
46mTOR signaling pathway_Homo sapiens_hsa041500.99989054
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.99162182
48VEGF signaling pathway_Homo sapiens_hsa043700.93407940
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93069376
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91860975
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91192265
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91083265
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.90607674
54Phototransduction_Homo sapiens_hsa047440.89428915
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85131120
56Dorso-ventral axis formation_Homo sapiens_hsa043200.83013873
57Endometrial cancer_Homo sapiens_hsa052130.82987370
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82248566
59Thyroid hormone synthesis_Homo sapiens_hsa049180.81517516
60Prion diseases_Homo sapiens_hsa050200.81111858
61Pancreatic secretion_Homo sapiens_hsa049720.81023211
62MAPK signaling pathway_Homo sapiens_hsa040100.79969868
63Oocyte meiosis_Homo sapiens_hsa041140.79795453
64Circadian rhythm_Homo sapiens_hsa047100.78769274
65Choline metabolism in cancer_Homo sapiens_hsa052310.78416204
66Non-small cell lung cancer_Homo sapiens_hsa052230.78126731
67Bile secretion_Homo sapiens_hsa049760.77754076
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75842994
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74956326
70Rap1 signaling pathway_Homo sapiens_hsa040150.74103522
71Cardiac muscle contraction_Homo sapiens_hsa042600.72034682
72Glucagon signaling pathway_Homo sapiens_hsa049220.71348349
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71305488
74Endocytosis_Homo sapiens_hsa041440.70271316
75Collecting duct acid secretion_Homo sapiens_hsa049660.69538275
76Nitrogen metabolism_Homo sapiens_hsa009100.68378597
77Wnt signaling pathway_Homo sapiens_hsa043100.67591951
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.67510440
79Insulin signaling pathway_Homo sapiens_hsa049100.66941757
80Vibrio cholerae infection_Homo sapiens_hsa051100.66061432
81Colorectal cancer_Homo sapiens_hsa052100.65669055
82Hedgehog signaling pathway_Homo sapiens_hsa043400.65443437
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65255531
84Chronic myeloid leukemia_Homo sapiens_hsa052200.62105889
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59851199
86Renal cell carcinoma_Homo sapiens_hsa052110.59086075
87Alcoholism_Homo sapiens_hsa050340.59071904
88AMPK signaling pathway_Homo sapiens_hsa041520.58536604
89Inositol phosphate metabolism_Homo sapiens_hsa005620.57856713
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57260519
91Proteoglycans in cancer_Homo sapiens_hsa052050.56118526
92Ras signaling pathway_Homo sapiens_hsa040140.55862723
93Tight junction_Homo sapiens_hsa045300.53722351
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53512094
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51857803
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51801288
97Chemokine signaling pathway_Homo sapiens_hsa040620.51368546
98Basal cell carcinoma_Homo sapiens_hsa052170.50458983
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.50278138
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50116029
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49725021
102Platelet activation_Homo sapiens_hsa046110.49490670
103Hippo signaling pathway_Homo sapiens_hsa043900.49254341
104Prolactin signaling pathway_Homo sapiens_hsa049170.48898356
105Focal adhesion_Homo sapiens_hsa045100.47727465
106Type I diabetes mellitus_Homo sapiens_hsa049400.45960419
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44390570
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44163848
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44060575
110Vitamin B6 metabolism_Homo sapiens_hsa007500.42308898
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41930313
112Arginine and proline metabolism_Homo sapiens_hsa003300.37521300
113Ovarian steroidogenesis_Homo sapiens_hsa049130.35999035
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.31430272

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