DTX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.79789195
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.65286366
3positive regulation by organism of defense response of other organism involved in symbiotic interact4.65286366
4modulation by symbiont of host immune response (GO:0052553)4.65286366
5positive regulation by symbiont of host defense response (GO:0052509)4.65286366
6modulation by symbiont of host defense response (GO:0052031)4.65286366
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.65286366
8neuronal stem cell maintenance (GO:0097150)4.57060631
9lateral sprouting from an epithelium (GO:0060601)4.52829597
10pattern specification involved in kidney development (GO:0061004)4.50528783
11presynaptic membrane organization (GO:0097090)4.42304130
12postsynaptic membrane organization (GO:0001941)4.34929017
13central nervous system myelination (GO:0022010)4.33985729
14axon ensheathment in central nervous system (GO:0032291)4.33985729
15macrophage activation involved in immune response (GO:0002281)4.33863347
16pyrimidine nucleobase catabolic process (GO:0006208)4.27436916
17axonal fasciculation (GO:0007413)4.06022085
18microglial cell activation (GO:0001774)4.03956866
19heart valve formation (GO:0003188)3.96990255
20nucleobase catabolic process (GO:0046113)3.84078777
21neuron recognition (GO:0008038)3.82210125
22layer formation in cerebral cortex (GO:0021819)3.81871074
23axonemal dynein complex assembly (GO:0070286)3.81761510
24negative regulation of cell killing (GO:0031342)3.74182937
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.74182937
26vocalization behavior (GO:0071625)3.68626552
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.62605204
28limb bud formation (GO:0060174)3.60146610
29central nervous system projection neuron axonogenesis (GO:0021952)3.60117152
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.58980946
31camera-type eye morphogenesis (GO:0048593)3.56010549
32apical protein localization (GO:0045176)3.53030809
33somite development (GO:0061053)3.50266379
34establishment of planar polarity (GO:0001736)3.35230998
35establishment of tissue polarity (GO:0007164)3.35230998
36neuron fate determination (GO:0048664)3.33123989
37negative regulation of oligodendrocyte differentiation (GO:0048715)3.31611470
38germ cell migration (GO:0008354)3.31590592
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.30637332
40cilium movement (GO:0003341)3.29959899
41negative regulation of astrocyte differentiation (GO:0048712)3.28864684
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28274083
43tongue development (GO:0043586)3.25658582
44regulation of NFAT protein import into nucleus (GO:0051532)3.22840620
45asymmetric protein localization (GO:0008105)3.21860887
46regulation of interferon-beta biosynthetic process (GO:0045357)3.20542127
47auditory behavior (GO:0031223)3.20187362
48cerebral cortex radially oriented cell migration (GO:0021799)3.19226219
49clathrin coat assembly (GO:0048268)3.17508910
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.17287193
51glomerulus development (GO:0032835)3.16508194
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15832220
53response to host immune response (GO:0052572)3.15832220
54radial glial cell differentiation (GO:0060019)3.14386551
55neuron projection extension involved in neuron projection guidance (GO:1902284)3.14030496
56axon extension involved in axon guidance (GO:0048846)3.14030496
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.09686371
58response to host (GO:0075136)3.09686371
59response to host defenses (GO:0052200)3.09686371
60neuron cell-cell adhesion (GO:0007158)3.08280536
61notochord development (GO:0030903)3.03771143
62positive regulation of mast cell activation involved in immune response (GO:0033008)3.01730473
63positive regulation of mast cell degranulation (GO:0043306)3.01730473
64macrophage activation (GO:0042116)2.99176502
65synaptic vesicle maturation (GO:0016188)2.98146794
66response to auditory stimulus (GO:0010996)2.97361401
67locomotory exploration behavior (GO:0035641)2.97310874
68cilium or flagellum-dependent cell motility (GO:0001539)2.96424888
69semaphorin-plexin signaling pathway (GO:0071526)2.96316463
70cochlea development (GO:0090102)2.94618539
71negative regulation of glial cell differentiation (GO:0045686)2.91508961
72retinal ganglion cell axon guidance (GO:0031290)2.91084015
73proline transport (GO:0015824)2.89889093
74establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.89411125
75ephrin receptor signaling pathway (GO:0048013)2.89229254
76lens fiber cell development (GO:0070307)2.88294561
77neutrophil mediated immunity (GO:0002446)2.83638084
78positive regulation of synapse assembly (GO:0051965)2.82236468
79positive regulation of mast cell activation (GO:0033005)2.82139309
80otic vesicle formation (GO:0030916)2.80807038
81cell-cell junction maintenance (GO:0045217)2.80313281
82neutrophil activation involved in immune response (GO:0002283)2.79218259
83regulation of leukocyte degranulation (GO:0043300)2.79051502
84epithelial cilium movement (GO:0003351)2.78822092
85positive regulation of leukocyte degranulation (GO:0043302)2.77944998
86dendrite morphogenesis (GO:0048813)2.77894946
87segment specification (GO:0007379)2.75625310
88response to peptidoglycan (GO:0032494)2.75417017
89cellular response to cholesterol (GO:0071397)2.72964413
90convergent extension (GO:0060026)2.72518872
91Notch signaling involved in heart development (GO:0061314)2.72455610
92I-kappaB phosphorylation (GO:0007252)2.71382793
93regulation of inclusion body assembly (GO:0090083)2.70981254
94cell proliferation involved in metanephros development (GO:0072203)2.68167453
95neutrophil chemotaxis (GO:0030593)2.68165691
96negative regulation of smoothened signaling pathway (GO:0045879)2.67226137
97mechanosensory behavior (GO:0007638)2.66256618
98respiratory burst (GO:0045730)2.66245923
99skeletal muscle organ development (GO:0060538)2.65679682
100membrane assembly (GO:0071709)2.64885308
101alanine transport (GO:0032328)2.64225439
102renal system development (GO:0072001)2.64169887
103axon extension (GO:0048675)2.64157031
104cGMP-mediated signaling (GO:0019934)2.63906097
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.63615774
106regulation of synapse structural plasticity (GO:0051823)2.63512681
107regulation of mast cell degranulation (GO:0043304)2.62860793
108Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.62790291
109cell adhesion mediated by integrin (GO:0033627)2.62550609
110non-canonical Wnt signaling pathway (GO:0035567)2.61139683
111neutrophil migration (GO:1990266)2.60676302
112post-anal tail morphogenesis (GO:0036342)2.60328693
113central nervous system neuron axonogenesis (GO:0021955)2.59839803
114regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58795684
115cell proliferation in forebrain (GO:0021846)2.58391014
116synaptic vesicle docking involved in exocytosis (GO:0016081)2.58285059
117killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.57102244
118disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.57102244
119apoptotic cell clearance (GO:0043277)2.57043754
120establishment of nucleus localization (GO:0040023)2.57035983
121regulation of astrocyte differentiation (GO:0048710)2.56646252
122negative regulation of inclusion body assembly (GO:0090084)2.55952275
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55917591
124macroautophagy (GO:0016236)2.54784844
125cerebellar granule cell differentiation (GO:0021707)2.54574962
126digestive tract morphogenesis (GO:0048546)2.54328661
127regulation of ARF protein signal transduction (GO:0032012)2.52985397
128regulation of regulated secretory pathway (GO:1903305)2.51845839
129forebrain neuron differentiation (GO:0021879)2.51759309
130positive regulation of cellular amide metabolic process (GO:0034250)2.51750627
131oligodendrocyte differentiation (GO:0048709)2.51056935
132establishment or maintenance of apical/basal cell polarity (GO:0035088)2.50753803
133establishment or maintenance of bipolar cell polarity (GO:0061245)2.50753803
134limb development (GO:0060173)2.49855694
135appendage development (GO:0048736)2.49855694
136positive regulation of vascular permeability (GO:0043117)2.48496560
137ethanol oxidation (GO:0006069)2.48024798
138regulation of establishment of planar polarity (GO:0090175)2.47671365
139myeloid cell activation involved in immune response (GO:0002275)2.47101293
140regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.46629771
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46358077
142G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.46178818
143ear development (GO:0043583)2.45948133
144establishment of mitochondrion localization (GO:0051654)2.45898540
145regulation of mast cell activation involved in immune response (GO:0033006)2.44880657
146receptor catabolic process (GO:0032801)2.44686329
147regulation of oligodendrocyte differentiation (GO:0048713)2.44681536
148positive regulation of chemokine biosynthetic process (GO:0045080)2.44509273
149lens morphogenesis in camera-type eye (GO:0002089)2.43765413
150hindbrain development (GO:0030902)2.43741162
151cell differentiation involved in kidney development (GO:0061005)2.42542882
152epithelial tube branching involved in lung morphogenesis (GO:0060441)2.41931032
153cranial nerve development (GO:0021545)2.41221542
154prepulse inhibition (GO:0060134)2.41002775
155positive regulation of axon extension (GO:0045773)2.37365312
156glucocorticoid receptor signaling pathway (GO:0042921)2.37075500
157cellular extravasation (GO:0045123)2.35945881
158cortical actin cytoskeleton organization (GO:0030866)2.35589993
159regulation of glutamate receptor signaling pathway (GO:1900449)2.35453713
160neuron projection extension (GO:1990138)2.34911638
161regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.34786829
162positive regulation of macrophage cytokine production (GO:0060907)2.34748946
163regulation of ARF GTPase activity (GO:0032312)2.34390965
164positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.33649893
165regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31925802
166negative regulation of granulocyte differentiation (GO:0030853)2.31834272
167response to muramyl dipeptide (GO:0032495)2.30656223
168positive regulation of heat generation (GO:0031652)2.29247870
169regulation of cholesterol storage (GO:0010885)2.26928723
170exploration behavior (GO:0035640)2.25291812
171positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25105356
172tolerance induction (GO:0002507)2.22569762
173leukocyte aggregation (GO:0070486)2.22273537
174granulocyte chemotaxis (GO:0071621)2.21214442
175chondroitin sulfate catabolic process (GO:0030207)2.21156878
176granulocyte activation (GO:0036230)2.17887391
177response to fungus (GO:0009620)2.17848097
178myeloid leukocyte mediated immunity (GO:0002444)2.17590982
179regulation of B cell receptor signaling pathway (GO:0050855)2.17335606
180glutamate secretion (GO:0014047)2.17158756
181positive regulation of filopodium assembly (GO:0051491)2.17129239
182low-density lipoprotein particle clearance (GO:0034383)2.15446381
183positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.15347082
184positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.15092741
185granulocyte migration (GO:0097530)2.14695719
186response to cholesterol (GO:0070723)2.14618104
187nerve growth factor signaling pathway (GO:0038180)2.14616994
188cell migration in hindbrain (GO:0021535)2.14091151
189dendritic spine morphogenesis (GO:0060997)2.13604909
190heparan sulfate proteoglycan metabolic process (GO:0030201)2.13062890
191negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.12829480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23683422
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.13274116
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.97707044
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.87887342
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.81131120
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53478864
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.44739395
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.40800171
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38249707
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.28310234
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.24774828
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.10776639
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10463398
14EZH2_22144423_ChIP-Seq_EOC_Human2.09765936
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07605834
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01303784
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.99122115
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91876784
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.87156694
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86839373
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82865788
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.78680653
23DROSHA_22980978_ChIP-Seq_HELA_Human1.75094668
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71007980
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69775593
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69281313
27TCF7_22412390_ChIP-Seq_EML_Mouse1.68157486
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64262305
29SPI1_23127762_ChIP-Seq_K562_Human1.63883458
30RING1B_27294783_Chip-Seq_ESCs_Mouse1.63873832
31REST_21632747_ChIP-Seq_MESCs_Mouse1.63381913
32KDM2B_26808549_Chip-Seq_K562_Human1.62917338
33KDM2B_26808549_Chip-Seq_DND41_Human1.60408720
34* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59788427
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58607130
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58387766
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57083941
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.56691168
39VDR_24787735_ChIP-Seq_THP-1_Human1.55150518
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.53388595
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52047226
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51347195
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49276936
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49054542
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.48971800
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45834527
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45597161
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43726638
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43013023
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41679120
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.41266640
52AR_21572438_ChIP-Seq_LNCaP_Human1.41148447
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40812895
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40198683
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38957050
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38609506
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37646110
58* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37606818
59* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37539383
60* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34997865
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33905782
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33845227
63* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33436314
64VDR_24763502_ChIP-Seq_THP-1_Human1.32498360
65LXR_22292898_ChIP-Seq_THP-1_Human1.31461179
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31040629
67* KDM2B_26808549_Chip-Seq_JURKAT_Human1.30695438
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30486070
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29961863
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29918504
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27982369
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27867660
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27670446
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.27623503
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26728725
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25405153
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25355545
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25355545
79* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23925606
80CLOCK_20551151_ChIP-Seq_293T_Human1.23197664
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.22762438
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.22619121
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22529238
84SCL_19346495_ChIP-Seq_HPC-7_Human1.22045554
85* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21960060
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21431427
87* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21354060
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20046717
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20046717
90* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19963170
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19742160
92VDR_21846776_ChIP-Seq_THP-1_Human1.19506930
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19422484
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19105927
95* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18605048
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.18375383
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17856338
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15987340
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13918058
100CTCF_27219007_Chip-Seq_Bcells_Human1.12566539
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11711846
102TP53_16413492_ChIP-PET_HCT116_Human1.10515436
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10314530
104* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10139036
105* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09945572
106JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09102881
107GBX2_23144817_ChIP-Seq_PC3_Human1.08380371
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.08208615
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.07981853
110AHR_22903824_ChIP-Seq_MCF-7_Human1.07094528
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.06135188
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.05762738
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05468273
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04835681
115MYC_22102868_ChIP-Seq_BL_Human1.04525893
116* RNF2_27304074_Chip-Seq_NSC_Mouse1.04248280
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03361464
118TP53_18474530_ChIP-ChIP_U2OS_Human1.02975477
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02660656
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01581766
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00978368
122AR_19668381_ChIP-Seq_PC3_Human1.00728651
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00504952
124RUNX_20019798_ChIP-Seq_JUKART_Human1.00257171
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99717732
126* RNF2_27304074_Chip-Seq_ESCs_Mouse0.99681620
127RXR_22108803_ChIP-Seq_LS180_Human0.99578327
128SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99473492
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99219406
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98862669
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.98547683
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98213512
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.97743489
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97338657
135PU_27001747_Chip-Seq_BMDM_Mouse0.96927447
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96615380
137PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96596934
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94096198
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93899931
140BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93704757
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.93232484
142NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93152268
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93013450
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92878098
145POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92542662
146ESR1_20079471_ChIP-ChIP_T-47D_Human0.91510115
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.91476420
148E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91192435
149RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88568859
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88343520
151ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88338828
152* EZH2_27294783_Chip-Seq_ESCs_Mouse0.88322299
153* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88102340
154ESR1_21235772_ChIP-Seq_MCF-7_Human0.87410798
155FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86673713
156GATA2_19941826_ChIP-Seq_K562_Human0.86582778
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86084676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.20540027
2MP0003303_peritoneal_inflammation4.94911543
3MP0003136_yellow_coat_color4.86915565
4MP0000569_abnormal_digit_pigmentation4.48658520
5MP0004859_abnormal_synaptic_plasticity3.63252274
6MP0003172_abnormal_lysosome_physiology3.48769040
7MP0004858_abnormal_nervous_system3.27271246
8MP0002653_abnormal_ependyma_morphology2.96251214
9MP0009379_abnormal_foot_pigmentation2.88546741
10MP0005058_abnormal_lysosome_morphology2.71490761
11MP0005076_abnormal_cell_differentiation2.71143343
12MP0003191_abnormal_cellular_cholesterol2.67183449
13MP0003880_abnormal_central_pattern2.61213075
14MP0003300_gastrointestinal_ulcer2.50416265
15MP0000604_amyloidosis2.43513367
16MP0003436_decreased_susceptibility_to2.40169516
17MP0003075_altered_response_to2.34769669
18MP0009278_abnormal_bone_marrow2.26187229
19MP0006082_CNS_inflammation2.21632818
20MP0002419_abnormal_innate_immunity2.20578174
21MP0003183_abnormal_peptide_metabolism2.19686428
22MP0009780_abnormal_chondrocyte_physiolo2.17641972
23MP0003938_abnormal_ear_development2.10882718
24MP0004510_myositis2.08966498
25MP0005248_abnormal_Harderian_gland2.06716316
26MP0003690_abnormal_glial_cell2.05418292
27MP0002249_abnormal_larynx_morphology2.03551116
28MP0000537_abnormal_urethra_morphology1.97258516
29MP0005167_abnormal_blood-brain_barrier1.91714694
30MP0005464_abnormal_platelet_physiology1.91064760
31MP0003705_abnormal_hypodermis_morpholog1.88669459
32MP0003329_amyloid_beta_deposits1.85309510
33MP0003122_maternal_imprinting1.85090428
34MP0005377_hearing/vestibular/ear_phenot1.85004664
35MP0003878_abnormal_ear_physiology1.85004664
36MP0010030_abnormal_orbit_morphology1.79484931
37MP0000026_abnormal_inner_ear1.78856266
38MP0001533_abnormal_skeleton_physiology1.75688360
39MP0001835_abnormal_antigen_presentation1.64974917
40MP0001984_abnormal_olfaction1.60525534
41MP0002734_abnormal_mechanical_nocicepti1.59517995
42MP0005423_abnormal_somatic_nervous1.57047197
43MP0003635_abnormal_synaptic_transmissio1.56125730
44MP0008961_abnormal_basal_metabolism1.55290397
45MP0002822_catalepsy1.54870597
46MP0005499_abnormal_olfactory_system1.54070726
47MP0005394_taste/olfaction_phenotype1.54070726
48MP0001346_abnormal_lacrimal_gland1.49417477
49MP0001485_abnormal_pinna_reflex1.49003365
50MP0001299_abnormal_eye_distance/1.47606705
51MP0002139_abnormal_hepatobiliary_system1.47118265
52MP0002998_abnormal_bone_remodeling1.46777387
53MP0001293_anophthalmia1.44955264
54MP0004130_abnormal_muscle_cell1.42289571
55MP0000631_abnormal_neuroendocrine_gland1.41795279
56MP0002233_abnormal_nose_morphology1.41422725
57MP0003634_abnormal_glial_cell1.39654253
58MP0005166_decreased_susceptibility_to1.39638549
59MP0004270_analgesia1.39476926
60MP0002063_abnormal_learning/memory/cond1.38580682
61MP0005000_abnormal_immune_tolerance1.36745880
62MP0002152_abnormal_brain_morphology1.36348602
63MP0002090_abnormal_vision1.35723727
64MP0003861_abnormal_nervous_system1.34809587
65MP0001958_emphysema1.34744547
66MP0002928_abnormal_bile_duct1.34737792
67MP0000778_abnormal_nervous_system1.32266669
68MP0002697_abnormal_eye_size1.29294745
69MP0002452_abnormal_antigen_presenting1.29057069
70MP0008438_abnormal_cutaneous_collagen1.28542871
71MP0009053_abnormal_anal_canal1.28300806
72MP0001486_abnormal_startle_reflex1.28247615
73MP0000343_altered_response_to1.27390381
74MP0008789_abnormal_olfactory_epithelium1.25310317
75MP0003283_abnormal_digestive_organ1.24112390
76MP0005025_abnormal_response_to1.24092970
77MP0002148_abnormal_hypersensitivity_rea1.23859099
78MP0002092_abnormal_eye_morphology1.23760517
79MP0000579_abnormal_nail_morphology1.23308004
80MP0003252_abnormal_bile_duct1.22797748
81MP0004811_abnormal_neuron_physiology1.22464185
82MP0000428_abnormal_craniofacial_morphol1.22450341
83MP0001286_abnormal_eye_development1.22146057
84MP0002882_abnormal_neuron_morphology1.22006712
85MP0004885_abnormal_endolymph1.21805138
86MP0003091_abnormal_cell_migration1.21558847
87MP0002735_abnormal_chemical_nociception1.19818628
88MP0000049_abnormal_middle_ear1.19236404
89MP0001502_abnormal_circadian_rhythm1.18117705
90MP0004742_abnormal_vestibular_system1.17208612
91MP0006292_abnormal_olfactory_placode1.14420686
92MP0000383_abnormal_hair_follicle1.13984962
93MP0004883_abnormal_blood_vessel1.13666518
94MP0005623_abnormal_meninges_morphology1.10651939
95MP0009840_abnormal_foam_cell1.10555872
96MP0004947_skin_inflammation1.09582626
97MP0001529_abnormal_vocalization1.08148962
98MP0003633_abnormal_nervous_system1.08000540
99MP0003119_abnormal_digestive_system1.07817240
100MP0009785_altered_susceptibility_to1.07433872
101MP0004133_heterotaxia1.06499743
102MP0002282_abnormal_trachea_morphology1.05078593
103MP0002064_seizures1.04859668
104MP0002184_abnormal_innervation1.04540085
105MP0001819_abnormal_immune_cell1.02939888
106MP0003448_altered_tumor_morphology1.02747179
107MP0003755_abnormal_palate_morphology1.02628394
108MP0001845_abnormal_inflammatory_respons1.02621360
109MP0001963_abnormal_hearing_physiology1.01647131
110MP0002420_abnormal_adaptive_immunity0.99170741
111MP0002067_abnormal_sensory_capabilities0.98959374
112MP0002723_abnormal_immune_serum0.98790416
113MP0000534_abnormal_ureter_morphology0.98758847
114MP0001851_eye_inflammation0.98244817
115MP0002752_abnormal_somatic_nervous0.97575570
116MP0003890_abnormal_embryonic-extraembry0.97415364
117MP0002938_white_spotting0.96059524
118MP0001970_abnormal_pain_threshold0.95873750
119MP0010678_abnormal_skin_adnexa0.95856428
120MP0010352_gastrointestinal_tract_polyps0.94778225
121MP0001440_abnormal_grooming_behavior0.94441924
122MP0010329_abnormal_lipoprotein_level0.94361271
123MP0002089_abnormal_postnatal_growth/wei0.94344422
124MP0003566_abnormal_cell_adhesion0.94062466
125MP0002111_abnormal_tail_morphology0.93972892
126MP0005257_abnormal_intraocular_pressure0.93139396
127MP0005187_abnormal_penis_morphology0.92621657
128MP0003942_abnormal_urinary_system0.92528041
129MP0003879_abnormal_hair_cell0.91568893
130MP0005409_darkened_coat_color0.90635432
131MP0010234_abnormal_vibrissa_follicle0.90173140
132MP0002116_abnormal_craniofacial_bone0.89650193
133MP0001915_intracranial_hemorrhage0.89369019
134MP0010307_abnormal_tumor_latency0.89121129
135MP0003045_fibrosis0.88963525
136MP0000762_abnormal_tongue_morphology0.87617771
137MP0002098_abnormal_vibrissa_morphology0.87537774
138MP0003453_abnormal_keratinocyte_physiol0.85409892
139MP0001177_atelectasis0.83839492
140MP0008569_lethality_at_weaning0.83457539
141MP0003221_abnormal_cardiomyocyte_apopto0.82286467
142MP0002272_abnormal_nervous_system0.82088236
143MP0002733_abnormal_thermal_nociception0.81501015
144MP0005195_abnormal_posterior_eye0.81074776
145MP0001968_abnormal_touch/_nociception0.80510925
146MP0001800_abnormal_humoral_immune0.80326359
147MP0005666_abnormal_adipose_tissue0.79599395
148MP0003937_abnormal_limbs/digits/tail_de0.78870766
149MP0003631_nervous_system_phenotype0.78536611
150MP0005391_vision/eye_phenotype0.78264137
151MP0002081_perinatal_lethality0.77980125
152MP0008004_abnormal_stomach_pH0.77861738
153MP0008469_abnormal_protein_level0.76709649
154MP0005164_abnormal_response_to0.75971861
155MP0009764_decreased_sensitivity_to0.75907614
156MP0002405_respiratory_system_inflammati0.75244782
157MP0009046_muscle_twitch0.74251815
158MP0005671_abnormal_response_to0.72845673
159MP0002909_abnormal_adrenal_gland0.72702829
160MP0000733_abnormal_muscle_development0.72484881
161MP0000249_abnormal_blood_vessel0.71637466
162MP0002572_abnormal_emotion/affect_behav0.70731782
163MP0009745_abnormal_behavioral_response0.70572780
164MP0005390_skeleton_phenotype0.70548113
165MP0005397_hematopoietic_system_phenotyp0.70433322
166MP0001545_abnormal_hematopoietic_system0.70433322
167MP0002896_abnormal_bone_mineralization0.69981867
168MP0000955_abnormal_spinal_cord0.68741580
169MP0001790_abnormal_immune_system0.67989556
170MP0005387_immune_system_phenotype0.67989556
171MP0000858_altered_metastatic_potential0.67881167
172MP0002736_abnormal_nociception_after0.66876216
173MP0005174_abnormal_tail_pigmentation0.66677641
174MP0001663_abnormal_digestive_system0.66470357
175MP0003724_increased_susceptibility_to0.66182652
176MP0000465_gastrointestinal_hemorrhage0.65241861
177MP0000371_diluted_coat_color0.63683405
178MP0003632_abnormal_nervous_system0.62740276
179MP0002557_abnormal_social/conspecific_i0.62607569

Predicted human phenotypes

RankGene SetZ-score
1Disinhibition (HP:0000734)4.51560194
2Increased cerebral lipofuscin (HP:0011813)4.19248501
3Recurrent abscess formation (HP:0002722)4.09691474
4Recurrent bacterial skin infections (HP:0005406)3.95549908
5Septo-optic dysplasia (HP:0100842)3.94358816
6Eczematoid dermatitis (HP:0000976)3.86077524
7Mutism (HP:0002300)3.83085353
8Recurrent gram-negative bacterial infections (HP:0005420)3.81864140
9Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.74426049
10Partial duplication of thumb phalanx (HP:0009944)3.71908776
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.71359362
12Abnormality of the diencephalon (HP:0010662)3.69112837
13Neonatal short-limb short stature (HP:0008921)3.67493951
14Systemic lupus erythematosus (HP:0002725)3.59179462
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.51724489
16Abnormal ciliary motility (HP:0012262)3.46467364
17Bronchomalacia (HP:0002780)3.44444311
18Abnormal respiratory motile cilium morphology (HP:0005938)3.42519835
19Abnormal respiratory epithelium morphology (HP:0012253)3.42519835
20Papilledema (HP:0001085)3.40218757
21Inappropriate behavior (HP:0000719)3.38008324
22Abnormal respiratory motile cilium physiology (HP:0012261)3.30818117
23Abnormality of liposaccharide metabolism (HP:0010968)3.19415939
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.19415939
25Abnormality of glycolipid metabolism (HP:0010969)3.19415939
26Esophageal atresia (HP:0002032)3.18838877
27Apathy (HP:0000741)3.17244202
28Cerebral aneurysm (HP:0004944)3.17198892
29Split foot (HP:0001839)3.09173590
30Focal motor seizures (HP:0011153)3.06148154
31Partial duplication of the phalanx of hand (HP:0009999)3.03177175
32Dynein arm defect of respiratory motile cilia (HP:0012255)3.01606339
33Absent/shortened dynein arms (HP:0200106)3.01606339
34Rhinitis (HP:0012384)3.01177589
35Diminished motivation (HP:0000745)2.99752966
36Abnormality of the 4th metacarpal (HP:0010012)2.94697311
37Supranuclear gaze palsy (HP:0000605)2.93965902
38Glomerulonephritis (HP:0000099)2.85717169
39Down-sloping shoulders (HP:0200021)2.82021410
40Absent septum pellucidum (HP:0001331)2.75216026
41Missing ribs (HP:0000921)2.69032280
42Hyperacusis (HP:0010780)2.67084364
43Anophthalmia (HP:0000528)2.61102808
44Arterial tortuosity (HP:0005116)2.59510039
45Supernumerary ribs (HP:0005815)2.58445135
46Midline defect of the nose (HP:0004122)2.58250899
47Hematochezia (HP:0002573)2.57392521
48Aplasia involving bones of the extremities (HP:0009825)2.57149566
49Aplasia involving bones of the upper limbs (HP:0009823)2.57149566
50Aplasia of the phalanges of the hand (HP:0009802)2.57149566
51Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.56369905
52Vertebral hypoplasia (HP:0008417)2.56369905
53Subacute progressive viral hepatitis (HP:0006572)2.54732300
54Tracheomalacia (HP:0002779)2.54692043
55Gingivitis (HP:0000230)2.54615689
56Chronic bronchitis (HP:0004469)2.52918582
57Cortical dysplasia (HP:0002539)2.49855983
58Complement deficiency (HP:0004431)2.48384153
59Hemivertebrae (HP:0002937)2.47379212
60Dysostosis multiplex (HP:0000943)2.47113747
61Striae distensae (HP:0001065)2.45502119
62Megalencephaly (HP:0001355)2.43064505
63High anterior hairline (HP:0009890)2.42669013
64Cerebral inclusion bodies (HP:0100314)2.42596874
65Neuronal loss in central nervous system (HP:0002529)2.42473498
66Trigonocephaly (HP:0000243)2.40451974
67Mucopolysacchariduria (HP:0008155)2.38600709
68Urinary glycosaminoglycan excretion (HP:0003541)2.38600709
69Abnormality of the septum pellucidum (HP:0007375)2.35036303
7011 pairs of ribs (HP:0000878)2.33485764
71Gastrointestinal atresia (HP:0002589)2.31979394
72Mediastinal lymphadenopathy (HP:0100721)2.31386774
73Cutaneous finger syndactyly (HP:0010554)2.29860554
74Neoplasm of the heart (HP:0100544)2.29597547
75Vitreoretinal degeneration (HP:0000655)2.29595794
76Hyperactive renin-angiotensin system (HP:0000841)2.28651167
77Vascular tortuosity (HP:0004948)2.27720589
78Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26073410
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26073410
80Abnormality of polysaccharide metabolism (HP:0011012)2.26073410
81Myokymia (HP:0002411)2.23169212
82Neurofibrillary tangles (HP:0002185)2.22666322
83Elfin facies (HP:0004428)2.21855588
84Mitral valve prolapse (HP:0001634)2.21050742
85Abnormality of macrophages (HP:0004311)2.21033622
86Vertebral clefting (HP:0008428)2.20028813
87Supernumerary bones of the axial skeleton (HP:0009144)2.19169883
88Axonal loss (HP:0003447)2.17933103
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16773478
90Broad face (HP:0000283)2.16767270
91Coronal craniosynostosis (HP:0004440)2.16708888
92Bronchiectasis (HP:0002110)2.15312244
93Abnormality of the distal phalanx of the thumb (HP:0009617)2.14806720
94Upper motor neuron abnormality (HP:0002127)2.14326784
95Maternal diabetes (HP:0009800)2.13515236
96Turricephaly (HP:0000262)2.13192245
97Bifid scrotum (HP:0000048)2.08404920
98Oligodactyly (hands) (HP:0001180)2.07871622
99Cutaneous syndactyly (HP:0012725)2.07487724
100Abnormality of complement system (HP:0005339)2.06915290
101Macroorchidism (HP:0000053)2.06797247
102Oligodactyly (HP:0012165)2.05070187
103Aortic aneurysm (HP:0004942)2.04841629
104Periodontitis (HP:0000704)2.04382800
105Absent frontal sinuses (HP:0002688)2.03432013
106Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.02931773
107Large earlobe (HP:0009748)2.02749506
108Renovascular hypertension (HP:0100817)2.02729268
109Optic nerve hypoplasia (HP:0000609)2.01611521
110Rib fusion (HP:0000902)1.99504514
111Short 4th metacarpal (HP:0010044)1.99349065
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99349065
113Shallow orbits (HP:0000586)1.99316148
114Thyroid-stimulating hormone excess (HP:0002925)1.98411028
115Obstructive lung disease (HP:0006536)1.98240342
116Chronic obstructive pulmonary disease (HP:0006510)1.98240342
117Hepatoblastoma (HP:0002884)1.97514026
118Abnormality of the ischium (HP:0003174)1.97260035
119Abnormality of the parietal bone (HP:0002696)1.96127126
120Amyotrophic lateral sclerosis (HP:0007354)1.95092058
121Nephritis (HP:0000123)1.95049603
122Drooling (HP:0002307)1.93746869
123Excessive salivation (HP:0003781)1.93746869
124Lymphangioma (HP:0100764)1.92791275
125Interstitial pulmonary disease (HP:0006530)1.91985595
126Thickened helices (HP:0000391)1.91865401
127Renal hypoplasia (HP:0000089)1.91291991
128Disproportionate tall stature (HP:0001519)1.90871070
129Increased density of long bones (HP:0006392)1.90851220
130Recurrent skin infections (HP:0001581)1.90763843
131Abnormality of the dental root (HP:0006486)1.90529662
132Taurodontia (HP:0000679)1.90529662
133Abnormality of permanent molar morphology (HP:0011071)1.90529662
134Mitral stenosis (HP:0001718)1.90189451
135Overriding aorta (HP:0002623)1.89135852
136Broad metatarsal (HP:0001783)1.87349919
137Urethral obstruction (HP:0000796)1.85998878
138Amyloidosis (HP:0011034)1.85793412
139Akinesia (HP:0002304)1.85133440
140Vertebral arch anomaly (HP:0008438)1.85122672
141Chin dimple (HP:0010751)1.84984923
142Myocardial infarction (HP:0001658)1.81167996
143Bilateral microphthalmos (HP:0007633)1.79920376
144Hand muscle atrophy (HP:0009130)1.78491804
145Pointed chin (HP:0000307)1.77908760
146Diplopia (HP:0000651)1.77279380
147Abnormality of binocular vision (HP:0011514)1.77279380
148Polyphagia (HP:0002591)1.76709923
149Flattened epiphyses (HP:0003071)1.76475048
150Abnormality of molar morphology (HP:0011070)1.75604961
151Abnormality of molar (HP:0011077)1.75604961
152Insomnia (HP:0100785)1.75134274
153Recurrent sinusitis (HP:0011108)1.75094279
154Retinal atrophy (HP:0001105)1.75041101
155Arnold-Chiari malformation (HP:0002308)1.74303705
156Nasal polyposis (HP:0100582)1.74285731
157Action tremor (HP:0002345)1.73645234
158Abnormality of the dental pulp (HP:0006479)1.72893209
159Autoimmune thrombocytopenia (HP:0001973)1.72160372
160Dilatation of the ascending aorta (HP:0005111)1.70817270
161Synostosis involving the elbow (HP:0003938)1.69791287
162Humeroradial synostosis (HP:0003041)1.69791287
163Abnormality of the motor neurons (HP:0002450)1.69743287
164Abnormal neuron morphology (HP:0012757)1.69743287
165Renal dysplasia (HP:0000110)1.69374902
166Abnormality of the incisor (HP:0000676)1.69291795
167Focal seizures (HP:0007359)1.68868255
168Abnormality of the lower motor neuron (HP:0002366)1.68738469
169Synostosis of carpal bones (HP:0005048)1.68579378
170Mixed hearing impairment (HP:0000410)1.68565343
171Abnormal number of incisors (HP:0011064)1.67920483
172Abnormality of incisor morphology (HP:0011063)1.67531356
173Hypoplasia of the ulna (HP:0003022)1.67504670
174Termporal pattern (HP:0011008)1.67309029
175Insidious onset (HP:0003587)1.67309029
176Atonic seizures (HP:0010819)1.67047752
177Cellulitis (HP:0100658)1.66911056
178Dementia (HP:0000726)1.66298011
179Thin ribs (HP:0000883)1.66133792
180Bone pain (HP:0002653)1.65245296
181Omphalocele (HP:0001539)1.65085132
182Personality changes (HP:0000751)1.64932648
183Shawl scrotum (HP:0000049)1.64917137
184Myositis (HP:0100614)1.64413219
185J-shaped sella turcica (HP:0002680)1.64110438
186Lower limb asymmetry (HP:0100559)1.63245267
187Enlarged penis (HP:0000040)1.62949808
188Vacuolated lymphocytes (HP:0001922)1.62445288
189Agnosia (HP:0010524)1.61480799
190Distal upper limb amyotrophy (HP:0007149)1.60509901
191Upper limb amyotrophy (HP:0009129)1.60509901
192Postural instability (HP:0002172)1.60473304
193Frequent falls (HP:0002359)1.60427323
194Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.60296939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.63087685
2PNCK4.02638577
3EPHA43.30648283
4CASK3.28539728
5TRIB32.83591268
6MAP3K92.77444871
7DAPK22.53896655
8TGFBR22.53778485
9RIPK42.31846891
10TNIK2.28068466
11PKN22.27843348
12EPHA32.07486307
13EPHA22.06195351
14STK38L2.02166581
15CAMK1D1.93889307
16CAMK1G1.92656796
17SIK21.86185858
18ERBB31.83785580
19CAMKK11.82395150
20EEF2K1.78078549
21RIPK11.75571747
22TSSK61.74891005
23NTRK21.69360925
24MINK11.68305742
25KSR11.66476914
26PTK61.61289974
27FGFR21.57835512
28MST1R1.48253393
29PAK61.45672401
30MAP3K101.44356949
31TBK11.40301155
32RPS6KA21.39753920
33CSF1R1.38190860
34MARK21.35216790
35DYRK1B1.29742951
36MATK1.24030429
37UHMK11.23256323
38BLK1.22632803
39KSR21.21623664
40BMX1.20847862
41ERN11.18961142
42MAP3K41.18002552
43JAK11.17138160
44DDR21.13544947
45CDK191.11772117
46SCYL21.10730923
47LMTK21.10527050
48SIK11.09537649
49BCR1.09209430
50NTRK11.08087911
51IRAK41.07027880
52TYRO31.06590049
53PHKG11.06493762
54PHKG21.06493762
55MAP3K141.05720938
56PAK41.05274737
57PLK21.03944293
58WEE11.03449167
59ALK0.99044562
60PDGFRA0.94924930
61MAP2K70.94848207
62TTN0.94512441
63FES0.94365767
64RET0.93143684
65EPHB20.92846544
66SGK2230.91966275
67SGK4940.91966275
68DAPK10.91304905
69SGK30.87048047
70ICK0.84964378
71LATS10.84782753
72LATS20.84378873
73KIT0.84033489
74TYK20.83248481
75ERBB20.82366094
76PRKCZ0.81595066
77NTRK30.81343731
78JAK20.80597328
79CDK60.80469165
80MET0.80153606
81HCK0.77800461
82STK240.77006931
83YES10.76808892
84WNK10.76464463
85FGR0.76340140
86CSNK1G20.76158030
87CDK50.71435891
88CHUK0.70484550
89PDGFRB0.69981820
90MAP2K40.69126936
91DMPK0.68189423
92FYN0.65800071
93STK110.65570875
94PRKD30.65179139
95PIK3CA0.63713787
96ROCK20.63502070
97PRKCG0.62218878
98MAP3K110.61134346
99CDK120.60883985
100TAOK30.60140064
101EGFR0.59817420
102MAPK120.59234457
103CAMKK20.58353909
104PRKCH0.57763379
105CLK10.57200782
106IRAK30.57087616
107DYRK1A0.56864985
108STK390.56239411
109GSK3A0.55658336
110CDK30.55527525
111NME10.54029157
112PAK20.53625930
113EPHB10.53542335
114FGFR30.53226655
115CSK0.52728634
116CDC42BPA0.51160200
117MTOR0.50866359
118CAMK40.50819159
119TESK10.49559323
120TAOK10.49449705
121MAP3K70.47875413
122PASK0.47393566
123CSNK1A1L0.47322736
124TGFBR10.45937637
125MAPK130.45642354
126SRC0.44932551
127SIK30.44677887
128CDK180.44486896
129SYK0.43797172
130MAP2K20.43192719
131SGK20.42554433
132CDK150.42122908
133FGFR40.41250953
134PDK10.41177535
135MAPK150.41149362
136OXSR10.39941455
137DYRK20.39557721
138CDK11A0.39487030
139ZAP700.39408867
140ROCK10.38819091
141SGK10.37480696
142IRAK10.37413505
143CAMK2B0.37346117
144PKN10.37217171
145MAP4K10.37204521
146CAMK10.35518925
147LRRK20.33681708
148CDK140.31728053
149WNK30.29748364

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.71311080
2Hedgehog signaling pathway_Homo sapiens_hsa043402.58957501
3Staphylococcus aureus infection_Homo sapiens_hsa051502.20165521
4Histidine metabolism_Homo sapiens_hsa003402.02084173
5Nicotine addiction_Homo sapiens_hsa050331.97137970
6Osteoclast differentiation_Homo sapiens_hsa043801.96774429
7Leishmaniasis_Homo sapiens_hsa051401.86760578
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84980788
9* Notch signaling pathway_Homo sapiens_hsa043301.80709222
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.72583757
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69798260
12Hippo signaling pathway_Homo sapiens_hsa043901.67139394
13Nitrogen metabolism_Homo sapiens_hsa009101.61797503
14Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.58698850
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56586190
16Lysosome_Homo sapiens_hsa041421.56335255
17PPAR signaling pathway_Homo sapiens_hsa033201.56005891
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54954002
19Retinol metabolism_Homo sapiens_hsa008301.53198381
20Bile secretion_Homo sapiens_hsa049761.52980436
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.50537257
22Tuberculosis_Homo sapiens_hsa051521.46872672
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44099942
24Melanogenesis_Homo sapiens_hsa049161.42838869
25Pertussis_Homo sapiens_hsa051331.41985215
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41957218
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39263107
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36944739
29Chronic myeloid leukemia_Homo sapiens_hsa052201.36738768
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36311734
31Chemical carcinogenesis_Homo sapiens_hsa052041.35598948
32B cell receptor signaling pathway_Homo sapiens_hsa046621.33693151
33Tight junction_Homo sapiens_hsa045301.32855824
34Glioma_Homo sapiens_hsa052141.32094890
35Pancreatic cancer_Homo sapiens_hsa052121.25820371
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24388293
37Type II diabetes mellitus_Homo sapiens_hsa049301.24168141
38Synaptic vesicle cycle_Homo sapiens_hsa047211.23307165
39Colorectal cancer_Homo sapiens_hsa052101.22638881
40Phagosome_Homo sapiens_hsa041451.20596544
41Glutamatergic synapse_Homo sapiens_hsa047241.20365838
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17992749
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17979487
44Endometrial cancer_Homo sapiens_hsa052131.17517629
45Phenylalanine metabolism_Homo sapiens_hsa003601.16852820
46Amphetamine addiction_Homo sapiens_hsa050311.16342268
47Thyroid hormone synthesis_Homo sapiens_hsa049181.16337223
48Toxoplasmosis_Homo sapiens_hsa051451.14223685
49Wnt signaling pathway_Homo sapiens_hsa043101.13014899
50Viral myocarditis_Homo sapiens_hsa054161.12869540
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.12439537
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11912903
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.11840989
54Estrogen signaling pathway_Homo sapiens_hsa049151.11734216
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11183011
56Protein digestion and absorption_Homo sapiens_hsa049741.09273755
57Prion diseases_Homo sapiens_hsa050201.09072184
58Legionellosis_Homo sapiens_hsa051341.08421953
59Salmonella infection_Homo sapiens_hsa051321.06894523
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06529627
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05673482
62TNF signaling pathway_Homo sapiens_hsa046681.04367644
63Amoebiasis_Homo sapiens_hsa051461.02372665
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02181706
65Axon guidance_Homo sapiens_hsa043601.01212309
66Fat digestion and absorption_Homo sapiens_hsa049751.01179412
67Chemokine signaling pathway_Homo sapiens_hsa040621.00140987
68Dorso-ventral axis formation_Homo sapiens_hsa043200.98384528
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96765494
70Glycerolipid metabolism_Homo sapiens_hsa005610.96566347
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96277752
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96058605
73mTOR signaling pathway_Homo sapiens_hsa041500.95470138
74beta-Alanine metabolism_Homo sapiens_hsa004100.93587193
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93503725
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91284292
77VEGF signaling pathway_Homo sapiens_hsa043700.89739293
78Renal cell carcinoma_Homo sapiens_hsa052110.88705062
79Non-small cell lung cancer_Homo sapiens_hsa052230.88452811
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87458719
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86568475
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84510313
83Caffeine metabolism_Homo sapiens_hsa002320.83528819
84Platelet activation_Homo sapiens_hsa046110.83165401
85Olfactory transduction_Homo sapiens_hsa047400.82681868
86Fatty acid degradation_Homo sapiens_hsa000710.82321758
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82098034
88ErbB signaling pathway_Homo sapiens_hsa040120.81304395
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.80865443
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80266309
91Fatty acid biosynthesis_Homo sapiens_hsa000610.80008635
92Choline metabolism in cancer_Homo sapiens_hsa052310.79569905
93Other glycan degradation_Homo sapiens_hsa005110.78494179
94Arginine biosynthesis_Homo sapiens_hsa002200.77383063
95Influenza A_Homo sapiens_hsa051640.77375012
96Morphine addiction_Homo sapiens_hsa050320.77159158
97GABAergic synapse_Homo sapiens_hsa047270.76879683
98Cholinergic synapse_Homo sapiens_hsa047250.76452831
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.76445254
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76326226
101Apoptosis_Homo sapiens_hsa042100.75830869
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.75708221
103Prolactin signaling pathway_Homo sapiens_hsa049170.75217070
104Hepatitis B_Homo sapiens_hsa051610.73008307
105Renin secretion_Homo sapiens_hsa049240.72951295
106Long-term potentiation_Homo sapiens_hsa047200.72827555
107Proteoglycans in cancer_Homo sapiens_hsa052050.72812290
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72649791
109Insulin secretion_Homo sapiens_hsa049110.72466608
110Tyrosine metabolism_Homo sapiens_hsa003500.71828151
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70800314
112Endocytosis_Homo sapiens_hsa041440.70469414
113Gastric acid secretion_Homo sapiens_hsa049710.70393049
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70360941
115GnRH signaling pathway_Homo sapiens_hsa049120.69949985
116Complement and coagulation cascades_Homo sapiens_hsa046100.69610811
117Mineral absorption_Homo sapiens_hsa049780.68245899
118Tryptophan metabolism_Homo sapiens_hsa003800.68030156
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67961427
120Focal adhesion_Homo sapiens_hsa045100.67909717
121Gap junction_Homo sapiens_hsa045400.67838601
122Insulin resistance_Homo sapiens_hsa049310.67668266
123Circadian entrainment_Homo sapiens_hsa047130.66184795
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.66004465
125Salivary secretion_Homo sapiens_hsa049700.65261683
126Taste transduction_Homo sapiens_hsa047420.64354518
127Steroid biosynthesis_Homo sapiens_hsa001000.64322588
128Insulin signaling pathway_Homo sapiens_hsa049100.64017462
129Asthma_Homo sapiens_hsa053100.63484637
130Rheumatoid arthritis_Homo sapiens_hsa053230.63274267
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.63214187
132Acute myeloid leukemia_Homo sapiens_hsa052210.62570743
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.62553244
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61742620
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60565895
136Shigellosis_Homo sapiens_hsa051310.60077329
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58863770
138Pathways in cancer_Homo sapiens_hsa052000.58784448
139Dopaminergic synapse_Homo sapiens_hsa047280.58749556
140Malaria_Homo sapiens_hsa051440.58680367
141Oxytocin signaling pathway_Homo sapiens_hsa049210.58599262
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57445058
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57167392
144Cocaine addiction_Homo sapiens_hsa050300.56481155
145Linoleic acid metabolism_Homo sapiens_hsa005910.56180031
146Rap1 signaling pathway_Homo sapiens_hsa040150.55942363
147Starch and sucrose metabolism_Homo sapiens_hsa005000.55609060
148MAPK signaling pathway_Homo sapiens_hsa040100.55488165
149Renin-angiotensin system_Homo sapiens_hsa046140.55145103
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55068015
151cAMP signaling pathway_Homo sapiens_hsa040240.54660138
152African trypanosomiasis_Homo sapiens_hsa051430.54377149
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54208817
154Adherens junction_Homo sapiens_hsa045200.53760161
155Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52857207
156T cell receptor signaling pathway_Homo sapiens_hsa046600.52587356
157ECM-receptor interaction_Homo sapiens_hsa045120.50715209
158Pancreatic secretion_Homo sapiens_hsa049720.45728227
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43742380
160Butanoate metabolism_Homo sapiens_hsa006500.42855613
161MicroRNAs in cancer_Homo sapiens_hsa052060.42740657
162alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41435553
163Ras signaling pathway_Homo sapiens_hsa040140.40665338

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