

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA strand elongation involved in DNA replication (GO:0006271) | 5.33599154 |
| 2 | telomere maintenance via semi-conservative replication (GO:0032201) | 5.14216668 |
| 3 | DNA strand elongation (GO:0022616) | 5.10900539 |
| 4 | DNA replication initiation (GO:0006270) | 4.99214213 |
| 5 | ribosomal small subunit assembly (GO:0000028) | 4.95958759 |
| 6 | DNA deamination (GO:0045006) | 4.72359902 |
| 7 | DNA replication checkpoint (GO:0000076) | 4.57719519 |
| 8 | telomere maintenance via recombination (GO:0000722) | 4.55085995 |
| 9 | nucleobase biosynthetic process (GO:0046112) | 4.41577967 |
| 10 | DNA unwinding involved in DNA replication (GO:0006268) | 4.35115988 |
| 11 | CENP-A containing nucleosome assembly (GO:0034080) | 4.34979365 |
| 12 | maturation of SSU-rRNA (GO:0030490) | 4.33315988 |
| 13 | chaperone-mediated protein transport (GO:0072321) | 4.31974972 |
| 14 | mitotic recombination (GO:0006312) | 4.29832574 |
| 15 | chromatin remodeling at centromere (GO:0031055) | 4.25968089 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.25076223 |
| 17 | purine nucleobase biosynthetic process (GO:0009113) | 4.17281963 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.17098343 |
| 19 | regulation of mitochondrial translation (GO:0070129) | 4.15655268 |
| 20 | telomere maintenance via telomere lengthening (GO:0010833) | 4.07729612 |
| 21 | viral transcription (GO:0019083) | 4.02494053 |
| 22 | ribosomal small subunit biogenesis (GO:0042274) | 3.99970531 |
| 23 | translational termination (GO:0006415) | 3.95886949 |
| 24 | mitotic metaphase plate congression (GO:0007080) | 3.93916079 |
| 25 | DNA replication-independent nucleosome organization (GO:0034724) | 3.92649926 |
| 26 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.92649926 |
| 27 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.92613890 |
| 28 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.91193307 |
| 29 | ribosomal large subunit biogenesis (GO:0042273) | 3.89405141 |
| 30 | formation of translation preinitiation complex (GO:0001731) | 3.88243697 |
| 31 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.85860654 |
| 32 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.85860654 |
| 33 | IMP biosynthetic process (GO:0006188) | 3.83929810 |
| 34 | kinetochore organization (GO:0051383) | 3.83161345 |
| 35 | sister chromatid segregation (GO:0000819) | 3.79789901 |
| 36 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.74048589 |
| 37 | DNA ligation (GO:0006266) | 3.70227096 |
| 38 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.69857365 |
| 39 | establishment of viral latency (GO:0019043) | 3.69703150 |
| 40 | protein localization to kinetochore (GO:0034501) | 3.68281426 |
| 41 | ATP synthesis coupled proton transport (GO:0015986) | 3.67512193 |
| 42 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.67512193 |
| 43 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.66096600 |
| 44 | spliceosomal snRNP assembly (GO:0000387) | 3.64469746 |
| 45 | ribosome biogenesis (GO:0042254) | 3.64445220 |
| 46 | translational elongation (GO:0006414) | 3.61730325 |
| 47 | kinetochore assembly (GO:0051382) | 3.60767829 |
| 48 | mitotic chromosome condensation (GO:0007076) | 3.55210490 |
| 49 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.52274706 |
| 50 | histone exchange (GO:0043486) | 3.51110032 |
| 51 | proteasome assembly (GO:0043248) | 3.50602943 |
| 52 | translational initiation (GO:0006413) | 3.50414383 |
| 53 | protein targeting to mitochondrion (GO:0006626) | 3.50408484 |
| 54 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.46166921 |
| 55 | rRNA processing (GO:0006364) | 3.44843546 |
| 56 | ribosome assembly (GO:0042255) | 3.44791379 |
| 57 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.42802827 |
| 58 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.42118694 |
| 59 | metaphase plate congression (GO:0051310) | 3.41278313 |
| 60 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.41025788 |
| 61 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.40380811 |
| 62 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.38898556 |
| 63 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.38898556 |
| 64 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.38898556 |
| 65 | cotranslational protein targeting to membrane (GO:0006613) | 3.37229943 |
| 66 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.36964442 |
| 67 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.36964442 |
| 68 | establishment of integrated proviral latency (GO:0075713) | 3.36457442 |
| 69 | viral mRNA export from host cell nucleus (GO:0046784) | 3.36016741 |
| 70 | IMP metabolic process (GO:0046040) | 3.35466842 |
| 71 | protein targeting to ER (GO:0045047) | 3.34972706 |
| 72 | mitotic nuclear envelope disassembly (GO:0007077) | 3.34237024 |
| 73 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.34078157 |
| 74 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.34078157 |
| 75 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.33949320 |
| 76 | rRNA metabolic process (GO:0016072) | 3.32609183 |
| 77 | spliceosomal complex assembly (GO:0000245) | 3.32330738 |
| 78 | pseudouridine synthesis (GO:0001522) | 3.30946581 |
| 79 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.30016464 |
| 80 | rRNA modification (GO:0000154) | 3.29091962 |
| 81 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.27530666 |
| 82 | protein complex biogenesis (GO:0070271) | 3.27263536 |
| 83 | positive regulation of ligase activity (GO:0051351) | 3.26032456 |
| 84 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.26021651 |
| 85 | protein localization to chromosome, centromeric region (GO:0071459) | 3.25012847 |
| 86 | establishment of protein localization to mitochondrion (GO:0072655) | 3.24121506 |
| 87 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.22246764 |
| 88 | NADH dehydrogenase complex assembly (GO:0010257) | 3.22246764 |
| 89 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.22246764 |
| 90 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.21528815 |
| 91 | termination of RNA polymerase III transcription (GO:0006386) | 3.20986642 |
| 92 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.20986642 |
| 93 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.19912567 |
| 94 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.19477582 |
| 95 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.18791632 |
| 96 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.17514629 |
| 97 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.16127993 |
| 98 | cell cycle G1/S phase transition (GO:0044843) | 3.16127993 |
| 99 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.15910212 |
| 100 | cullin deneddylation (GO:0010388) | 3.15748777 |
| 101 | protein localization to endoplasmic reticulum (GO:0070972) | 3.15481972 |
| 102 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.15100539 |
| 103 | cellular protein complex disassembly (GO:0043624) | 3.14901798 |
| 104 | telomere organization (GO:0032200) | 3.14079083 |
| 105 | telomere maintenance (GO:0000723) | 3.13845899 |
| 106 | protein localization to mitochondrion (GO:0070585) | 3.12746382 |
| 107 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.12742113 |
| 108 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.12404675 |
| 109 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.12404675 |
| 110 | spindle checkpoint (GO:0031577) | 3.12335564 |
| 111 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.12224360 |
| 112 | protein deneddylation (GO:0000338) | 3.10139191 |
| 113 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.09476359 |
| 114 | establishment of chromosome localization (GO:0051303) | 3.09056221 |
| 115 | viral life cycle (GO:0019058) | 3.08561500 |
| 116 | translation (GO:0006412) | 3.08453349 |
| 117 | regulation of spindle organization (GO:0090224) | 3.08086005 |
| 118 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.07993168 |
| 119 | base-excision repair (GO:0006284) | 3.07416995 |
| 120 | regulation of ligase activity (GO:0051340) | 3.06304894 |
| 121 | mitotic sister chromatid segregation (GO:0000070) | 3.05905088 |
| 122 | negative regulation of chromosome segregation (GO:0051985) | 3.05476906 |
| 123 | mismatch repair (GO:0006298) | 3.04899143 |
| 124 | L-serine metabolic process (GO:0006563) | 3.04637282 |
| 125 | DNA damage response, detection of DNA damage (GO:0042769) | 3.03597331 |
| 126 | protein maturation by protein folding (GO:0022417) | 3.02557282 |
| 127 | respiratory electron transport chain (GO:0022904) | 3.01774970 |
| 128 | membrane disassembly (GO:0030397) | 3.01524348 |
| 129 | nuclear envelope disassembly (GO:0051081) | 3.01524348 |
| 130 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.01473254 |
| 131 | negative regulation of ligase activity (GO:0051352) | 2.99230279 |
| 132 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.99230279 |
| 133 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.98656316 |
| 134 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.98656316 |
| 135 | DNA replication (GO:0006260) | 2.92943175 |
| 136 | protein K6-linked ubiquitination (GO:0085020) | 2.92894896 |
| 137 | cellular component biogenesis (GO:0044085) | 2.92350636 |
| 138 | RNA splicing, via transesterification reactions (GO:0000375) | 2.90414069 |
| 139 | protein complex disassembly (GO:0043241) | 2.90408163 |
| 140 | 7-methylguanosine mRNA capping (GO:0006370) | 2.90050931 |
| 141 | nuclear pore organization (GO:0006999) | 2.89417279 |
| 142 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.89118567 |
| 143 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.88279232 |
| 144 | mRNA splicing, via spliceosome (GO:0000398) | 2.88279232 |
| 145 | negative regulation of sister chromatid segregation (GO:0033046) | 2.88097343 |
| 146 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.88097343 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.03587533 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.50398916 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.82397334 |
| 4 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.66604527 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.65227690 |
| 6 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.43589034 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.22059367 |
| 8 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.12226249 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.06340300 |
| 10 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.05405931 |
| 11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.01697896 |
| 12 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.00380133 |
| 13 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.98076831 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.92481890 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.79693721 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.78353979 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.51032691 |
| 18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.41269965 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.39502257 |
| 20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.38303123 |
| 21 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.34613460 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.31849269 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.30172913 |
| 24 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.19743893 |
| 25 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.12791726 |
| 26 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.12110363 |
| 27 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.10715342 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.10090235 |
| 29 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.06984988 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.06259152 |
| 31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.05200287 |
| 32 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.00513950 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.91590774 |
| 34 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.88825193 |
| 35 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.88538132 |
| 36 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.84550169 |
| 37 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.83219459 |
| 38 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.82904123 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.81140782 |
| 40 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.76913744 |
| 41 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.75227068 |
| 42 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.74439046 |
| 43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.74155238 |
| 44 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.72790524 |
| 45 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.70851392 |
| 46 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.70068583 |
| 47 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.69085316 |
| 48 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.66256607 |
| 49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62972113 |
| 50 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.62456858 |
| 51 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.54259999 |
| 52 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.53774081 |
| 53 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.48317009 |
| 54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.42747749 |
| 55 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.39708428 |
| 56 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.39540827 |
| 57 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.35296611 |
| 58 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.35070148 |
| 59 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.32184960 |
| 60 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.31629315 |
| 61 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.30706950 |
| 62 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30624638 |
| 63 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27529278 |
| 64 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.23612526 |
| 65 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.23195752 |
| 66 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.22723124 |
| 67 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.18929694 |
| 68 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.16530491 |
| 69 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.15103751 |
| 70 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.14243215 |
| 71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.12492241 |
| 72 | MYC_22102868_ChIP-Seq_BL_Human | 1.12091141 |
| 73 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.12008288 |
| 74 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.11637822 |
| 75 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.08053506 |
| 76 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08032491 |
| 77 | * CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.03395422 |
| 78 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.02620524 |
| 79 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.01260060 |
| 80 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.00720957 |
| 81 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.00381482 |
| 82 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.97180995 |
| 83 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.96271937 |
| 84 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.94973532 |
| 85 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.94672886 |
| 86 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.94108201 |
| 87 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.91344549 |
| 88 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.88490146 |
| 89 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.88446683 |
| 90 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.86350856 |
| 91 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.85870182 |
| 92 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.85167787 |
| 93 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.85154775 |
| 94 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.84831180 |
| 95 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.83134682 |
| 96 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.81443068 |
| 97 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.80747370 |
| 98 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.79375176 |
| 99 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.78924019 |
| 100 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.78905502 |
| 101 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.78765163 |
| 102 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.77729792 |
| 103 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.77421446 |
| 104 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.76657841 |
| 105 | * TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.76496803 |
| 106 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.76116312 |
| 107 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.75876065 |
| 108 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.75686513 |
| 109 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.75625658 |
| 110 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.75006457 |
| 111 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.74332917 |
| 112 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.74323596 |
| 113 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.73319315 |
| 114 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.72880934 |
| 115 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.72848466 |
| 116 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.72701372 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.74048995 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.95283782 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.58170738 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.43374797 |
| 5 | MP0008057_abnormal_DNA_replication | 4.28506051 |
| 6 | MP0003077_abnormal_cell_cycle | 4.08106990 |
| 7 | MP0008058_abnormal_DNA_repair | 3.85046874 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.08388012 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.84161387 |
| 10 | MP0002396_abnormal_hematopoietic_system | 2.44296949 |
| 11 | MP0003123_paternal_imprinting | 2.43296989 |
| 12 | MP0003786_premature_aging | 2.28954936 |
| 13 | MP0001730_embryonic_growth_arrest | 2.11134876 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.08580504 |
| 15 | MP0006292_abnormal_olfactory_placode | 1.93010526 |
| 16 | MP0003806_abnormal_nucleotide_metabolis | 1.81580955 |
| 17 | MP0008877_abnormal_DNA_methylation | 1.77763101 |
| 18 | MP0003718_maternal_effect | 1.70592071 |
| 19 | MP0000490_abnormal_crypts_of | 1.69778163 |
| 20 | MP0009379_abnormal_foot_pigmentation | 1.64840981 |
| 21 | MP0002163_abnormal_gland_morphology | 1.64573759 |
| 22 | MP0010352_gastrointestinal_tract_polyps | 1.61054809 |
| 23 | MP0001697_abnormal_embryo_size | 1.57391649 |
| 24 | MP0001672_abnormal_embryogenesis/_devel | 1.56533423 |
| 25 | MP0005380_embryogenesis_phenotype | 1.56533423 |
| 26 | MP0003121_genomic_imprinting | 1.49905587 |
| 27 | MP0000313_abnormal_cell_death | 1.47860738 |
| 28 | MP0001529_abnormal_vocalization | 1.46488156 |
| 29 | MP0010030_abnormal_orbit_morphology | 1.45154025 |
| 30 | MP0002080_prenatal_lethality | 1.44496159 |
| 31 | MP0003315_abnormal_perineum_morphology | 1.42604361 |
| 32 | MP0002085_abnormal_embryonic_tissue | 1.37802530 |
| 33 | MP0003984_embryonic_growth_retardation | 1.37720941 |
| 34 | MP0002088_abnormal_embryonic_growth/wei | 1.33369814 |
| 35 | MP0002019_abnormal_tumor_incidence | 1.31486356 |
| 36 | MP0001293_anophthalmia | 1.29352576 |
| 37 | MP0003567_abnormal_fetal_cardiomyocyte | 1.29227030 |
| 38 | MP0002210_abnormal_sex_determination | 1.29039417 |
| 39 | MP0010307_abnormal_tumor_latency | 1.25498438 |
| 40 | MP0003186_abnormal_redox_activity | 1.24381305 |
| 41 | MP0004133_heterotaxia | 1.23753643 |
| 42 | MP0004808_abnormal_hematopoietic_stem | 1.23692238 |
| 43 | MP0002132_abnormal_respiratory_system | 1.23552618 |
| 44 | MP0005397_hematopoietic_system_phenotyp | 1.19955172 |
| 45 | MP0001545_abnormal_hematopoietic_system | 1.19955172 |
| 46 | MP0005075_abnormal_melanosome_morpholog | 1.19651968 |
| 47 | MP0002086_abnormal_extraembryonic_tissu | 1.18197777 |
| 48 | MP0004197_abnormal_fetal_growth/weight/ | 1.17092408 |
| 49 | MP0002160_abnormal_reproductive_system | 1.16536363 |
| 50 | MP0002084_abnormal_developmental_patter | 1.15792317 |
| 51 | MP0009333_abnormal_splenocyte_physiolog | 1.15026195 |
| 52 | MP0001145_abnormal_male_reproductive | 1.11460791 |
| 53 | MP0003763_abnormal_thymus_physiology | 1.11259204 |
| 54 | MP0005499_abnormal_olfactory_system | 1.10081127 |
| 55 | MP0005394_taste/olfaction_phenotype | 1.10081127 |
| 56 | MP0002938_white_spotting | 1.09413482 |
| 57 | MP0003136_yellow_coat_color | 1.09408872 |
| 58 | MP0005084_abnormal_gallbladder_morpholo | 1.08150996 |
| 59 | MP0002877_abnormal_melanocyte_morpholog | 1.06936391 |
| 60 | MP0004147_increased_porphyrin_level | 1.06636401 |
| 61 | MP0003890_abnormal_embryonic-extraembry | 1.06093215 |
| 62 | MP0003941_abnormal_skin_development | 1.04644864 |
| 63 | MP0005408_hypopigmentation | 1.04129548 |
| 64 | MP0005389_reproductive_system_phenotype | 1.01517402 |
| 65 | MP0000703_abnormal_thymus_morphology | 1.01086725 |
| 66 | MP0002234_abnormal_pharynx_morphology | 1.00251491 |
| 67 | MP0002095_abnormal_skin_pigmentation | 1.00157994 |
| 68 | MP0001764_abnormal_homeostasis | 0.95255274 |
| 69 | MP0000653_abnormal_sex_gland | 0.95130464 |
| 70 | MP0001929_abnormal_gametogenesis | 0.94646143 |
| 71 | MP0002398_abnormal_bone_marrow | 0.91693998 |
| 72 | MP0000015_abnormal_ear_pigmentation | 0.91417999 |
| 73 | MP0006036_abnormal_mitochondrial_physio | 0.90311350 |
| 74 | MP0003119_abnormal_digestive_system | 0.89798842 |
| 75 | MP0001119_abnormal_female_reproductive | 0.89453066 |
| 76 | MP0001727_abnormal_embryo_implantation | 0.88808749 |
| 77 | MP0002722_abnormal_immune_system | 0.88545099 |
| 78 | MP0006035_abnormal_mitochondrial_morpho | 0.87731344 |
| 79 | MP0005174_abnormal_tail_pigmentation | 0.85551387 |
| 80 | MP0001661_extended_life_span | 0.85143716 |
| 81 | MP0000689_abnormal_spleen_morphology | 0.85132058 |
| 82 | MP0006072_abnormal_retinal_apoptosis | 0.82840087 |
| 83 | MP0006054_spinal_hemorrhage | 0.82665696 |
| 84 | MP0002697_abnormal_eye_size | 0.81868245 |
| 85 | MP0005501_abnormal_skin_physiology | 0.80560744 |
| 86 | MP0002111_abnormal_tail_morphology | 0.79296881 |
| 87 | MP0000647_abnormal_sebaceous_gland | 0.78566165 |
| 88 | MP0000358_abnormal_cell_content/ | 0.78163088 |
| 89 | MP0001919_abnormal_reproductive_system | 0.77387631 |
| 90 | MP0001286_abnormal_eye_development | 0.75668412 |
| 91 | MP0008789_abnormal_olfactory_epithelium | 0.74018858 |
| 92 | MP0000566_synostosis | 0.73376574 |
| 93 | MP0000858_altered_metastatic_potential | 0.73148324 |
| 94 | MP0000049_abnormal_middle_ear | 0.73004463 |
| 95 | MP0002102_abnormal_ear_morphology | 0.72863309 |
| 96 | MP0003698_abnormal_male_reproductive | 0.72363162 |
| 97 | MP0001346_abnormal_lacrimal_gland | 0.72299947 |
| 98 | MP0002429_abnormal_blood_cell | 0.72224237 |
| 99 | MP0002233_abnormal_nose_morphology | 0.71571745 |
| 100 | MP0000537_abnormal_urethra_morphology | 0.71392286 |
| 101 | MP0003937_abnormal_limbs/digits/tail_de | 0.69951836 |
| 102 | MP0005384_cellular_phenotype | 0.69320719 |
| 103 | MP0001188_hyperpigmentation | 0.67590663 |
| 104 | MP0005171_absent_coat_pigmentation | 0.65676680 |
| 105 | MP0005379_endocrine/exocrine_gland_phen | 0.63954553 |
| 106 | MP0002075_abnormal_coat/hair_pigmentati | 0.63745142 |
| 107 | MP0002161_abnormal_fertility/fecundity | 0.63082312 |
| 108 | MP0009053_abnormal_anal_canal | 0.62741674 |
| 109 | MP0001186_pigmentation_phenotype | 0.60875754 |
| 110 | MP0003221_abnormal_cardiomyocyte_apopto | 0.60825338 |
| 111 | MP0009697_abnormal_copulation | 0.60355093 |
| 112 | MP0008995_early_reproductive_senescence | 0.60320621 |
| 113 | MP0002736_abnormal_nociception_after | 0.59678708 |
| 114 | MP0001881_abnormal_mammary_gland | 0.59487609 |
| 115 | MP0001853_heart_inflammation | 0.59403020 |
| 116 | MP0009672_abnormal_birth_weight | 0.58757127 |
| 117 | MP0000372_irregular_coat_pigmentation | 0.58450198 |
| 118 | MP0002751_abnormal_autonomic_nervous | 0.58109897 |
| 119 | MP0002653_abnormal_ependyma_morphology | 0.57191081 |
| 120 | MP0005266_abnormal_metabolism | 0.55399553 |
| 121 | MP0002177_abnormal_outer_ear | 0.54751669 |
| 122 | MP0000516_abnormal_urinary_system | 0.54416950 |
| 123 | MP0005367_renal/urinary_system_phenotyp | 0.54416950 |
| 124 | MP0005621_abnormal_cell_physiology | 0.54138014 |
| 125 | MP0003861_abnormal_nervous_system | 0.52930000 |
| 126 | MP0005083_abnormal_biliary_tract | 0.51996336 |
| 127 | MP0003385_abnormal_body_wall | 0.51911897 |
| 128 | MP0005395_other_phenotype | 0.51802875 |
| 129 | MP0003942_abnormal_urinary_system | 0.51672558 |
| 130 | MP0008260_abnormal_autophagy | 0.51259796 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.66908077 |
| 2 | Reticulocytopenia (HP:0001896) | 4.92908662 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 4.87311877 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.68270356 |
| 5 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.55053400 |
| 6 | Abnormal number of erythroid precursors (HP:0012131) | 4.46335731 |
| 7 | Acute encephalopathy (HP:0006846) | 4.37964917 |
| 8 | Breast hypoplasia (HP:0003187) | 4.28289428 |
| 9 | Mitochondrial inheritance (HP:0001427) | 4.19845936 |
| 10 | Chromsome breakage (HP:0040012) | 4.18121591 |
| 11 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.10917753 |
| 12 | Hepatocellular necrosis (HP:0001404) | 4.02545515 |
| 13 | Progressive macrocephaly (HP:0004481) | 3.77366982 |
| 14 | Patellar aplasia (HP:0006443) | 3.62384085 |
| 15 | Hepatic necrosis (HP:0002605) | 3.60010400 |
| 16 | Aplastic anemia (HP:0001915) | 3.44770814 |
| 17 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.40958764 |
| 18 | Meckel diverticulum (HP:0002245) | 3.38251448 |
| 19 | Oral leukoplakia (HP:0002745) | 3.37904697 |
| 20 | Cerebral edema (HP:0002181) | 3.32652703 |
| 21 | Colon cancer (HP:0003003) | 3.25338178 |
| 22 | Abnormality of the ileum (HP:0001549) | 3.25101770 |
| 23 | Abnormality of the preputium (HP:0100587) | 3.18521320 |
| 24 | Macrocytic anemia (HP:0001972) | 3.09826171 |
| 25 | Abnormality of chromosome stability (HP:0003220) | 3.07873935 |
| 26 | Pallor (HP:0000980) | 3.06376784 |
| 27 | Absent thumb (HP:0009777) | 3.01550611 |
| 28 | Lactic acidosis (HP:0003128) | 2.98871693 |
| 29 | Medulloblastoma (HP:0002885) | 2.95932469 |
| 30 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.95251419 |
| 31 | Carpal bone hypoplasia (HP:0001498) | 2.93922277 |
| 32 | Selective tooth agenesis (HP:0001592) | 2.88582888 |
| 33 | Duplicated collecting system (HP:0000081) | 2.87154553 |
| 34 | Cerebral hypomyelination (HP:0006808) | 2.84978204 |
| 35 | Rough bone trabeculation (HP:0100670) | 2.84087500 |
| 36 | Abnormality of the anterior horn cell (HP:0006802) | 2.83090066 |
| 37 | Degeneration of anterior horn cells (HP:0002398) | 2.83090066 |
| 38 | Lipid accumulation in hepatocytes (HP:0006561) | 2.82212159 |
| 39 | Absent radius (HP:0003974) | 2.75885392 |
| 40 | Increased serum pyruvate (HP:0003542) | 2.74822282 |
| 41 | Abnormality of the renal collecting system (HP:0004742) | 2.68267981 |
| 42 | Microretrognathia (HP:0000308) | 2.67687716 |
| 43 | Myelodysplasia (HP:0002863) | 2.67032836 |
| 44 | Abnormality of glycolysis (HP:0004366) | 2.64496893 |
| 45 | Respiratory failure (HP:0002878) | 2.62933169 |
| 46 | Exercise intolerance (HP:0003546) | 2.61540185 |
| 47 | Absent forearm bone (HP:0003953) | 2.60165136 |
| 48 | Aplasia involving forearm bones (HP:0009822) | 2.60165136 |
| 49 | Abnormal protein glycosylation (HP:0012346) | 2.59916104 |
| 50 | Abnormal glycosylation (HP:0012345) | 2.59916104 |
| 51 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.59916104 |
| 52 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.59916104 |
| 53 | Premature graying of hair (HP:0002216) | 2.59732406 |
| 54 | Small intestinal stenosis (HP:0012848) | 2.59585104 |
| 55 | Duodenal stenosis (HP:0100867) | 2.59585104 |
| 56 | Bone marrow hypocellularity (HP:0005528) | 2.58536329 |
| 57 | Impulsivity (HP:0100710) | 2.58338701 |
| 58 | 11 pairs of ribs (HP:0000878) | 2.51155282 |
| 59 | Increased intramyocellular lipid droplets (HP:0012240) | 2.47831816 |
| 60 | Renal Fanconi syndrome (HP:0001994) | 2.44840014 |
| 61 | Ectopic kidney (HP:0000086) | 2.44759594 |
| 62 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.42615305 |
| 63 | Horseshoe kidney (HP:0000085) | 2.42568726 |
| 64 | Type I transferrin isoform profile (HP:0003642) | 2.39773543 |
| 65 | Abnormal lung lobation (HP:0002101) | 2.38331921 |
| 66 | Abnormal number of incisors (HP:0011064) | 2.38196200 |
| 67 | Triphalangeal thumb (HP:0001199) | 2.37569377 |
| 68 | Reduced antithrombin III activity (HP:0001976) | 2.35664082 |
| 69 | Supernumerary spleens (HP:0009799) | 2.35276996 |
| 70 | Leukodystrophy (HP:0002415) | 2.33614723 |
| 71 | Ependymoma (HP:0002888) | 2.27973530 |
| 72 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.27189449 |
| 73 | Asplenia (HP:0001746) | 2.26505884 |
| 74 | Pancytopenia (HP:0001876) | 2.24920833 |
| 75 | Testicular atrophy (HP:0000029) | 2.24271881 |
| 76 | Agnosia (HP:0010524) | 2.22414302 |
| 77 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.22192083 |
| 78 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.22192083 |
| 79 | Sloping forehead (HP:0000340) | 2.19921317 |
| 80 | Atresia of the external auditory canal (HP:0000413) | 2.19723708 |
| 81 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.19108636 |
| 82 | Neoplasm of the pancreas (HP:0002894) | 2.18188259 |
| 83 | Hypoplastic pelvis (HP:0008839) | 2.17984576 |
| 84 | Tracheoesophageal fistula (HP:0002575) | 2.17538313 |
| 85 | Cellular immunodeficiency (HP:0005374) | 2.14558385 |
| 86 | Abnormality of the duodenum (HP:0002246) | 2.14061142 |
| 87 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.12864881 |
| 88 | Abnormality of alanine metabolism (HP:0010916) | 2.12864881 |
| 89 | Hyperalaninemia (HP:0003348) | 2.12864881 |
| 90 | Progressive muscle weakness (HP:0003323) | 2.10857107 |
| 91 | Abnormality of DNA repair (HP:0003254) | 2.09544894 |
| 92 | Abnormality of the labia minora (HP:0012880) | 2.08957592 |
| 93 | Increased serum lactate (HP:0002151) | 2.08908005 |
| 94 | Cleft eyelid (HP:0000625) | 2.08510726 |
| 95 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.07925682 |
| 96 | Clubbing of toes (HP:0100760) | 2.07706422 |
| 97 | Squamous cell carcinoma (HP:0002860) | 2.07617038 |
| 98 | Increased muscle lipid content (HP:0009058) | 2.07145782 |
| 99 | Broad distal phalanx of finger (HP:0009836) | 2.06475959 |
| 100 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.03718451 |
| 101 | Abnormal trabecular bone morphology (HP:0100671) | 2.03633963 |
| 102 | Microvesicular hepatic steatosis (HP:0001414) | 2.03282254 |
| 103 | Facial cleft (HP:0002006) | 2.02668138 |
| 104 | Abnormality of the carotid arteries (HP:0005344) | 2.01565781 |
| 105 | 3-Methylglutaconic aciduria (HP:0003535) | 1.98121204 |
| 106 | Lethargy (HP:0001254) | 1.96882116 |
| 107 | Respiratory difficulties (HP:0002880) | 1.95909732 |
| 108 | Optic disc pallor (HP:0000543) | 1.95064672 |
| 109 | Secondary amenorrhea (HP:0000869) | 1.93131389 |
| 110 | Short thumb (HP:0009778) | 1.92974679 |
| 111 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.92626883 |
| 112 | Hypoplasia of the radius (HP:0002984) | 1.92418687 |
| 113 | Trismus (HP:0000211) | 1.90957203 |
| 114 | Embryonal renal neoplasm (HP:0011794) | 1.90418479 |
| 115 | Slender long bone (HP:0003100) | 1.89940026 |
| 116 | Rhabdomyosarcoma (HP:0002859) | 1.88389525 |
| 117 | Opisthotonus (HP:0002179) | 1.88344504 |
| 118 | Progressive microcephaly (HP:0000253) | 1.87600417 |
| 119 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.86092446 |
| 120 | Thrombocytosis (HP:0001894) | 1.85969874 |
| 121 | Multiple enchondromatosis (HP:0005701) | 1.84882614 |
| 122 | Hyperglycinemia (HP:0002154) | 1.83026259 |
| 123 | CNS demyelination (HP:0007305) | 1.82095096 |
| 124 | Lymphoma (HP:0002665) | 1.81174228 |
| 125 | Exertional dyspnea (HP:0002875) | 1.80389832 |
| 126 | Hypoplasia of the pons (HP:0012110) | 1.80317044 |
| 127 | Abnormality of the umbilical cord (HP:0010881) | 1.79341344 |
| 128 | Premature ovarian failure (HP:0008209) | 1.79205616 |
| 129 | Muscle fiber atrophy (HP:0100295) | 1.78914461 |
| 130 | Optic nerve coloboma (HP:0000588) | 1.78862905 |
| 131 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.76376827 |
| 132 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.75780368 |
| 133 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.75570083 |
| 134 | Absent epiphyses (HP:0010577) | 1.75570083 |
| 135 | Abnormality of reticulocytes (HP:0004312) | 1.75006312 |
| 136 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.74239942 |
| 137 | Type 2 muscle fiber atrophy (HP:0003554) | 1.71283386 |
| 138 | Missing ribs (HP:0000921) | 1.70908375 |
| 139 | Sparse eyelashes (HP:0000653) | 1.70233064 |
| 140 | Duplication of thumb phalanx (HP:0009942) | 1.69941162 |
| 141 | Megaloblastic anemia (HP:0001889) | 1.69898173 |
| 142 | Acute lymphatic leukemia (HP:0006721) | 1.69349776 |
| 143 | Increased CSF lactate (HP:0002490) | 1.67218918 |
| 144 | Increased hepatocellular lipid droplets (HP:0006565) | 1.67179868 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.51023666 |
| 2 | VRK2 | 4.49588123 |
| 3 | WEE1 | 4.42594198 |
| 4 | CDC7 | 3.89806619 |
| 5 | STK16 | 3.37208840 |
| 6 | SRPK1 | 3.31855837 |
| 7 | EIF2AK1 | 3.09976337 |
| 8 | PLK4 | 2.57830899 |
| 9 | NME2 | 2.54771759 |
| 10 | VRK1 | 2.48383986 |
| 11 | NEK2 | 2.40451286 |
| 12 | ACVR1B | 2.23682941 |
| 13 | BRSK2 | 2.20989361 |
| 14 | MKNK1 | 2.19146711 |
| 15 | TSSK6 | 2.08712143 |
| 16 | TTK | 2.00307726 |
| 17 | PLK1 | 1.98852380 |
| 18 | NEK1 | 1.92919768 |
| 19 | EIF2AK3 | 1.86070839 |
| 20 | TLK1 | 1.85380917 |
| 21 | ATR | 1.78111775 |
| 22 | TESK2 | 1.77644300 |
| 23 | CDK7 | 1.76920281 |
| 24 | PASK | 1.72205737 |
| 25 | ZAK | 1.72116843 |
| 26 | RPS6KB2 | 1.70309821 |
| 27 | DYRK3 | 1.64788361 |
| 28 | AURKB | 1.63249794 |
| 29 | MKNK2 | 1.62659319 |
| 30 | CCNB1 | 1.57674205 |
| 31 | PLK3 | 1.57261501 |
| 32 | CHEK2 | 1.47400221 |
| 33 | BRSK1 | 1.43568415 |
| 34 | TRIM28 | 1.40032779 |
| 35 | EPHA2 | 1.35855215 |
| 36 | AURKA | 1.32678564 |
| 37 | ARAF | 1.24929335 |
| 38 | NUAK1 | 1.24026253 |
| 39 | PIM2 | 1.15850997 |
| 40 | RPS6KA4 | 1.14796870 |
| 41 | CHEK1 | 1.10817745 |
| 42 | STK4 | 1.09375708 |
| 43 | PDK2 | 1.08610988 |
| 44 | CDK8 | 1.06216313 |
| 45 | TAF1 | 1.05096358 |
| 46 | MAP3K8 | 0.99837961 |
| 47 | CDK4 | 0.99609965 |
| 48 | CSNK1G3 | 0.99041533 |
| 49 | SMG1 | 0.94903844 |
| 50 | TGFBR1 | 0.92177763 |
| 51 | PAK4 | 0.89552265 |
| 52 | PIM1 | 0.89085836 |
| 53 | EIF2AK2 | 0.88073472 |
| 54 | MAP4K2 | 0.82090760 |
| 55 | ATM | 0.80981055 |
| 56 | CSNK2A1 | 0.79405140 |
| 57 | CDK2 | 0.76709780 |
| 58 | CSNK2A2 | 0.75730661 |
| 59 | STK10 | 0.75449502 |
| 60 | CSNK1G1 | 0.74988557 |
| 61 | BRAF | 0.74738351 |
| 62 | CLK1 | 0.74591749 |
| 63 | KDR | 0.73875306 |
| 64 | FLT3 | 0.72220240 |
| 65 | CSNK1A1L | 0.70665457 |
| 66 | MAP3K12 | 0.70007117 |
| 67 | MST4 | 0.69832222 |
| 68 | SCYL2 | 0.65845072 |
| 69 | IRAK4 | 0.65490221 |
| 70 | MST1R | 0.64183945 |
| 71 | RPS6KA5 | 0.64179486 |
| 72 | TESK1 | 0.63385612 |
| 73 | AKT3 | 0.63155969 |
| 74 | YES1 | 0.63053454 |
| 75 | CSNK1G2 | 0.61634338 |
| 76 | TAOK2 | 0.61249426 |
| 77 | DYRK2 | 0.60251062 |
| 78 | BRD4 | 0.58672261 |
| 79 | CDK1 | 0.57664177 |
| 80 | PAK1 | 0.57062851 |
| 81 | PRKCI | 0.52722536 |
| 82 | PBK | 0.52345989 |
| 83 | NME1 | 0.51693612 |
| 84 | BCKDK | 0.46147329 |
| 85 | MAP2K7 | 0.45631474 |
| 86 | WNK3 | 0.45608871 |
| 87 | CDK12 | 0.45514602 |
| 88 | CDK11A | 0.44443436 |
| 89 | BTK | 0.42974360 |
| 90 | TEC | 0.42691644 |
| 91 | CDK14 | 0.42509864 |
| 92 | CDK18 | 0.42258265 |
| 93 | BLK | 0.41425113 |
| 94 | ERBB4 | 0.41407235 |
| 95 | IRAK3 | 0.40696709 |
| 96 | CDK15 | 0.40528799 |
| 97 | MAPKAPK3 | 0.37451207 |
| 98 | STK38L | 0.37194532 |
| 99 | MAP4K1 | 0.37050850 |
| 100 | MAPKAPK5 | 0.34769871 |
| 101 | LIMK1 | 0.34478081 |
| 102 | BCR | 0.33699026 |
| 103 | AKT2 | 0.33602246 |
| 104 | LRRK2 | 0.33528179 |
| 105 | DAPK3 | 0.33024839 |
| 106 | MAP3K11 | 0.32740547 |
| 107 | CDK19 | 0.32042825 |
| 108 | EEF2K | 0.30038592 |
| 109 | MAP2K3 | 0.29756870 |
| 110 | MELK | 0.29640809 |
| 111 | MAP3K10 | 0.29511113 |
| 112 | BMPR1B | 0.28202378 |
| 113 | RPS6KA6 | 0.28060511 |
| 114 | RPS6KL1 | 0.27079188 |
| 115 | RPS6KC1 | 0.27079188 |
| 116 | ALK | 0.26964958 |
| 117 | DAPK1 | 0.26443426 |
| 118 | CDK6 | 0.26213635 |
| 119 | ILK | 0.26030973 |
| 120 | PRKDC | 0.25812744 |
| 121 | PNCK | 0.23820755 |
| 122 | ABL2 | 0.23261077 |
| 123 | KIT | 0.22613471 |
| 124 | TXK | 0.22031034 |
| 125 | LYN | 0.21217604 |
| 126 | PLK2 | 0.19907757 |
| 127 | MET | 0.19215013 |
| 128 | STK24 | 0.18966158 |
| 129 | CSNK1E | 0.18937181 |
| 130 | CDK9 | 0.18481733 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.41375477 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.57865535 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.98838160 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.47792483 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.43211379 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.41100531 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.36461221 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 3.27135767 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 3.21259656 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 3.05665446 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.81467409 |
| 12 | * Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.69287124 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.60561150 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 2.58915736 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.46297711 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.27667156 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.15758622 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 2.00098995 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.93194707 |
| 20 | Purine metabolism_Homo sapiens_hsa00230 | 1.54328067 |
| 21 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.50167547 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.40505392 |
| 23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.40504836 |
| 24 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.40036793 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.30046416 |
| 26 | Protein export_Homo sapiens_hsa03060 | 1.20948889 |
| 27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.16741938 |
| 28 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.10523610 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.08345087 |
| 30 | Huntingtons disease_Homo sapiens_hsa05016 | 1.01912422 |
| 31 | Parkinsons disease_Homo sapiens_hsa05012 | 0.99179787 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.91877126 |
| 33 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.87043007 |
| 34 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.85407263 |
| 35 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.84563210 |
| 36 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.82784271 |
| 37 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.80885258 |
| 38 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.80706284 |
| 39 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.79672994 |
| 40 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.79052442 |
| 41 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.77014695 |
| 42 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.74590508 |
| 43 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.73416246 |
| 44 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.72992324 |
| 45 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.72732547 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.72674207 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.68500222 |
| 48 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.67700176 |
| 49 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.65992238 |
| 50 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.65399215 |
| 51 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.63149064 |
| 52 | Sulfur relay system_Homo sapiens_hsa04122 | 0.62784910 |
| 53 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.61677676 |
| 54 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.61545809 |
| 55 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.59423038 |
| 56 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.58131274 |
| 57 | HTLV-I infection_Homo sapiens_hsa05166 | 0.57102462 |
| 58 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.52883458 |
| 59 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.52464323 |
| 60 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.49325430 |
| 61 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.47243782 |
| 62 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.47229918 |
| 63 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.47089458 |
| 64 | Thyroid cancer_Homo sapiens_hsa05216 | 0.45698418 |
| 65 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44422206 |
| 66 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.39874312 |
| 67 | Peroxisome_Homo sapiens_hsa04146 | 0.39820652 |
| 68 | Alcoholism_Homo sapiens_hsa05034 | 0.39115811 |
| 69 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.38150742 |
| 70 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.37066361 |
| 71 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.35985870 |
| 72 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.35720313 |
| 73 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.35683863 |
| 74 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.35624032 |
| 75 | Carbon metabolism_Homo sapiens_hsa01200 | 0.35421269 |
| 76 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.35398618 |
| 77 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.35145666 |
| 78 | Alzheimers disease_Homo sapiens_hsa05010 | 0.34391310 |
| 79 | Legionellosis_Homo sapiens_hsa05134 | 0.33983565 |
| 80 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.33045573 |
| 81 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.32626154 |
| 82 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.32418859 |
| 83 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.31954520 |
| 84 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.30715447 |
| 85 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28991678 |
| 86 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.25509526 |
| 87 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.24870991 |
| 88 | Apoptosis_Homo sapiens_hsa04210 | 0.24019893 |
| 89 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.23825305 |
| 90 | Measles_Homo sapiens_hsa05162 | 0.21992343 |
| 91 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.21432852 |
| 92 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.21232672 |
| 93 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.20347817 |
| 94 | Galactose metabolism_Homo sapiens_hsa00052 | 0.19619186 |
| 95 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.19298352 |
| 96 | Hepatitis B_Homo sapiens_hsa05161 | 0.18959268 |
| 97 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.18335190 |
| 98 | Shigellosis_Homo sapiens_hsa05131 | 0.18213154 |
| 99 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.17915047 |
| 100 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.17307192 |
| 101 | Lysine degradation_Homo sapiens_hsa00310 | 0.15651556 |
| 102 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.15288781 |
| 103 | Colorectal cancer_Homo sapiens_hsa05210 | 0.15031886 |
| 104 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.14566724 |
| 105 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.14492301 |
| 106 | Bladder cancer_Homo sapiens_hsa05219 | 0.14390276 |
| 107 | Pathways in cancer_Homo sapiens_hsa05200 | 0.13696581 |
| 108 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.12553949 |
| 109 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.12226385 |
| 110 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.12168422 |
| 111 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.12137076 |
| 112 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.11298683 |
| 113 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.11148536 |
| 114 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.10744878 |
| 115 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.10175749 |
| 116 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.10164684 |
| 117 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.09453300 |
| 118 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.09257407 |
| 119 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.07484975 |
| 120 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.07392357 |
| 121 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.07224093 |
| 122 | Influenza A_Homo sapiens_hsa05164 | 0.06619728 |
| 123 | Melanoma_Homo sapiens_hsa05218 | 0.06438217 |
| 124 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.04897080 |
| 125 | Asthma_Homo sapiens_hsa05310 | 0.04739958 |
| 126 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.02448725 |
| 127 | Phototransduction_Homo sapiens_hsa04744 | 0.02087782 |
| 128 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.01060385 |

