DUOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.91520896
2keratinization (GO:0031424)9.34503014
3motile cilium assembly (GO:0044458)9.21687251
4epithelial cilium movement (GO:0003351)9.16733414
5establishment of skin barrier (GO:0061436)8.11858851
6regulation of water loss via skin (GO:0033561)7.48700166
7axoneme assembly (GO:0035082)7.44347901
8surfactant homeostasis (GO:0043129)6.77043651
9peptide cross-linking (GO:0018149)6.53022356
10positive regulation of respiratory burst (GO:0060267)6.43074766
11left/right pattern formation (GO:0060972)5.76083043
12chemical homeostasis within a tissue (GO:0048875)5.67190151
13bundle of His cell to Purkinje myocyte communication (GO:0086069)5.49479652
14primary alcohol catabolic process (GO:0034310)5.42849844
15regulation of cilium movement (GO:0003352)5.37427925
16multicellular organismal water homeostasis (GO:0050891)5.35529873
17cell-substrate junction assembly (GO:0007044)5.11920520
18hair cycle (GO:0042633)5.11690866
19molting cycle (GO:0042303)5.11690866
20left/right axis specification (GO:0070986)4.97489546
21keratinocyte differentiation (GO:0030216)4.78602863
22skin morphogenesis (GO:0043589)4.67990503
23microtubule bundle formation (GO:0001578)4.58368224
24ectoderm development (GO:0007398)4.57021040
25ethanol metabolic process (GO:0006067)4.48735175
26cilium organization (GO:0044782)4.39959588
27water homeostasis (GO:0030104)4.39672997
28epidermis development (GO:0008544)4.32123387
29cilium assembly (GO:0042384)4.28168434
30establishment of tissue polarity (GO:0007164)4.27287458
31establishment of planar polarity (GO:0001736)4.27287458
32keratinocyte proliferation (GO:0043616)4.22828012
33pattern specification involved in kidney development (GO:0061004)4.19239714
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.17392927
35intraciliary transport (GO:0042073)4.14804044
36negative regulation of keratinocyte proliferation (GO:0010839)4.13362862
37regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.11578932
38lung epithelium development (GO:0060428)4.05646522
39lateral sprouting from an epithelium (GO:0060601)4.02695870
40vitamin transmembrane transport (GO:0035461)3.99232893
41ventricular system development (GO:0021591)3.93396919
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.89053915
43epidermal cell differentiation (GO:0009913)3.85982917
44negative regulation of humoral immune response (GO:0002921)3.69929119
45opsonization (GO:0008228)3.68881237
46keratinocyte development (GO:0003334)3.65962214
47gland morphogenesis (GO:0022612)3.65669347
48negative regulation of cell fate specification (GO:0009996)3.65588999
49protein localization to cilium (GO:0061512)3.62207402
50planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56818843
51intermediate filament organization (GO:0045109)3.55522277
52detection of molecule of bacterial origin (GO:0032490)3.53295186
53diterpenoid biosynthetic process (GO:0016102)3.53196182
54cilium morphogenesis (GO:0060271)3.52595012
55skin development (GO:0043588)3.51197418
56positive regulation of p38MAPK cascade (GO:1900745)3.46780534
57plasma membrane repair (GO:0001778)3.44266870
58negative regulation of T cell differentiation in thymus (GO:0033085)3.41868230
59cellular component assembly involved in morphogenesis (GO:0010927)3.41157821
60response to xenobiotic stimulus (GO:0009410)3.40773942
61regulation of microtubule-based movement (GO:0060632)3.39543089
62negative regulation of immunoglobulin mediated immune response (GO:0002890)3.38126213
63negative regulation of B cell mediated immunity (GO:0002713)3.38126213
64ethanol oxidation (GO:0006069)3.34665925
65phosphatidylserine acyl-chain remodeling (GO:0036150)3.34320945
66negative regulation of leukocyte chemotaxis (GO:0002689)3.33885895
67regulation of cardioblast differentiation (GO:0051890)3.32444227
68epithelial cell-cell adhesion (GO:0090136)3.27822497
69regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26936487
70G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.24914136
71collagen fibril organization (GO:0030199)3.23534427
72cell projection assembly (GO:0030031)3.18847513
73retinoic acid metabolic process (GO:0042573)3.16785128
74mesodermal cell differentiation (GO:0048333)3.15985079
75pyrimidine-containing compound transmembrane transport (GO:0072531)3.14441944
76polyol transport (GO:0015791)3.13790699
77exogenous drug catabolic process (GO:0042738)3.13757519
78establishment or maintenance of monopolar cell polarity (GO:0061339)3.13130888
79establishment of monopolar cell polarity (GO:0061162)3.13130888
80regulation of germinal center formation (GO:0002634)3.12645062
81basement membrane organization (GO:0071711)3.12342820
82regulation of hair follicle development (GO:0051797)3.11905828
83regulation of p38MAPK cascade (GO:1900744)3.11387551
84tolerance induction (GO:0002507)3.11373981
85sodium ion homeostasis (GO:0055078)3.09921537
86long-chain fatty acid biosynthetic process (GO:0042759)3.09726599
87fatty-acyl-CoA biosynthetic process (GO:0046949)3.09621746
88establishment of apical/basal cell polarity (GO:0035089)3.09101787
89long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.08814455
90regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.04605201
91embryonic viscerocranium morphogenesis (GO:0048703)3.03832019
92segment specification (GO:0007379)3.02820814
93lateral ventricle development (GO:0021670)3.02568155
94negative regulation of cell fate commitment (GO:0010454)3.02043014
95renal system development (GO:0072001)3.00939757
96tooth mineralization (GO:0034505)2.93940471
97phosphatidylinositol acyl-chain remodeling (GO:0036149)2.93297534
98atrioventricular valve morphogenesis (GO:0003181)2.93054702
99microtubule-based movement (GO:0007018)2.92501207
100growth hormone receptor signaling pathway (GO:0060396)2.92101540
101lipoxygenase pathway (GO:0019372)2.91449422
102regulation of keratinocyte proliferation (GO:0010837)2.89945533
103glomerular epithelial cell development (GO:0072310)2.88411512
104regulation of interleukin-5 production (GO:0032674)2.88072831
105negative regulation of complement activation (GO:0045916)2.86832279
106endodermal cell differentiation (GO:0035987)2.84895326
107cytoplasmic microtubule organization (GO:0031122)2.83049803
108positive regulation of epidermis development (GO:0045684)2.81902679
109phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.79271665
110non-canonical Wnt signaling pathway (GO:0035567)2.78703458
111mammary gland epithelial cell differentiation (GO:0060644)2.78676373
112phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77335651
113membrane budding (GO:0006900)2.76907239
114cornea development in camera-type eye (GO:0061303)2.76694300
115regulation of hair cycle (GO:0042634)2.74225080
116proximal/distal pattern formation (GO:0009954)2.74138232
117retinol metabolic process (GO:0042572)2.74015820
118renal absorption (GO:0070293)2.72856561
119wound healing (GO:0042060)2.72287324
120positive regulation of macrophage activation (GO:0043032)2.71229823
121thioester biosynthetic process (GO:0035384)2.71078354
122acyl-CoA biosynthetic process (GO:0071616)2.71078354
123carnitine shuttle (GO:0006853)2.69536108
124drug catabolic process (GO:0042737)2.68843335
125centriole assembly (GO:0098534)2.68498074
126regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68336440
127apical protein localization (GO:0045176)2.67201582
128ventricular cardiac muscle cell action potential (GO:0086005)2.66268332
129primary alcohol metabolic process (GO:0034308)2.66003285
130positive regulation of tolerance induction (GO:0002645)2.63450065
131one-carbon compound transport (GO:0019755)2.62857494
132protein heterotrimerization (GO:0070208)2.62532695
133odontogenesis (GO:0042476)2.62531636
134cellular response to vitamin D (GO:0071305)2.62197552
135polarized epithelial cell differentiation (GO:0030859)2.61336333
136regulation of epidermis development (GO:0045682)2.60657135
137positive regulation of hair cycle (GO:0042635)2.60208251
138positive regulation of hair follicle development (GO:0051798)2.60208251
139calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.59164662
140regulation of transforming growth factor beta2 production (GO:0032909)2.58902461
141extracellular matrix disassembly (GO:0022617)2.58415417
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.57898363
143dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57221047
144positive regulation of odontogenesis (GO:0042482)2.56106964
145intermediate filament cytoskeleton organization (GO:0045104)2.55556076
146embryonic cranial skeleton morphogenesis (GO:0048701)2.55207519
147negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.54501009
148collagen metabolic process (GO:0032963)2.54479135
149multicellular organismal macromolecule metabolic process (GO:0044259)2.54477911
150collagen catabolic process (GO:0030574)2.53221532
151excretion (GO:0007588)2.52479873
152chondrocyte proliferation (GO:0035988)2.52016395
153long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.51789338
154regulation of hippo signaling (GO:0035330)2.50622365
155detection of external biotic stimulus (GO:0098581)2.49727572
156negative regulation of cardiac muscle tissue growth (GO:0055022)2.49689178
157negative regulation of heart growth (GO:0061117)2.49689178
158type B pancreatic cell proliferation (GO:0044342)2.48582829
159intermediate filament-based process (GO:0045103)2.47729987
160regulation of ruffle assembly (GO:1900027)2.47725521
161regulation of keratinocyte differentiation (GO:0045616)2.44706678
162terpenoid biosynthetic process (GO:0016114)2.43851329
163cellular response to growth hormone stimulus (GO:0071378)2.43534628
164photoreceptor cell maintenance (GO:0045494)2.43334007
165positive regulation of epidermal cell differentiation (GO:0045606)2.43000077
166regulation of skeletal muscle contraction (GO:0014819)2.42543364
167multicellular organismal metabolic process (GO:0044236)2.42483555
168renal filtration (GO:0097205)2.42431453
169regulation of interleukin-13 production (GO:0032656)2.40932729
170phosphatidylcholine acyl-chain remodeling (GO:0036151)2.37767255
171iron ion import (GO:0097286)2.37102024
172regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33339715
173cellular anion homeostasis (GO:0030002)2.32394141
174regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.32025736
175cellular response to antibiotic (GO:0071236)2.29850852
176sperm capacitation (GO:0048240)2.28326845
177* thyroid hormone generation (GO:0006590)2.27129885
178axonemal dynein complex assembly (GO:0070286)13.7939837
179hemidesmosome assembly (GO:0031581)13.0066459
180cilium or flagellum-dependent cell motility (GO:0001539)12.4438265
181cilium movement (GO:0003341)10.5170122
182epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.1550374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.61506061
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.20637430
3* SOX9_24532713_ChIP-Seq_HFSC_Mouse3.07207819
4ZNF263_19887448_ChIP-Seq_K562_Human2.83613761
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.74165879
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.64956289
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.58843677
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56992312
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51254659
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46801102
11DROSHA_22980978_ChIP-Seq_HELA_Human2.34555670
12* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.21472096
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16282638
14VDR_22108803_ChIP-Seq_LS180_Human2.06859804
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00047174
16TP63_17297297_ChIP-ChIP_HaCaT_Human12.6875043
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99515819
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99515819
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97364056
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77825467
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.69995243
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69314246
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66282260
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62758441
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.62426741
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61542870
27CJUN_26792858_Chip-Seq_BT549_Human1.56681761
28CLOCK_20551151_ChIP-Seq_293T_Human1.54646854
29RACK7_27058665_Chip-Seq_MCF-7_Human1.52319989
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49011561
31SOX2_20726797_ChIP-Seq_SW620_Human1.44545094
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44401282
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41525520
34KLF5_25053715_ChIP-Seq_YYC3_Human1.41418573
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40712071
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38972490
37EZH2_22144423_ChIP-Seq_EOC_Human1.37993120
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30777410
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30572235
40AR_21572438_ChIP-Seq_LNCaP_Human1.29408254
41* EZH2_27294783_Chip-Seq_ESCs_Mouse1.28632310
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27071361
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.26393710
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.26145795
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25666277
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25544584
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22472702
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22102201
49SMAD4_21799915_ChIP-Seq_A2780_Human1.19987693
50BCAT_22108803_ChIP-Seq_LS180_Human1.18928754
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17758008
52* TP63_22573176_ChIP-Seq_HFKS_Human1.17690218
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17150914
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16615433
55ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16321897
56* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15607238
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.14549167
58ATF3_27146783_Chip-Seq_COLON_Human1.14500943
59ZNF274_21170338_ChIP-Seq_K562_Hela1.14139547
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.13771789
61FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11938879
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11622063
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11173701
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10890857
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.10337930
66* TP63_23658742_ChIP-Seq_EP156T_Human1.09655503
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09142052
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08879373
69AHR_22903824_ChIP-Seq_MCF-7_Human1.08752092
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.08323940
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.08323940
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.06762505
73GATA3_24758297_ChIP-Seq_MCF-7_Human1.06066672
74LXR_22292898_ChIP-Seq_THP-1_Human1.05954214
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.05137312
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04870109
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04227499
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.04014534
79ETV1_20927104_ChIP-Seq_GIST48_Human1.03848691
80TCF4_22108803_ChIP-Seq_LS180_Human1.03801929
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03101672
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99944420
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99563881
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99510964
85ERG_21242973_ChIP-ChIP_JURKAT_Human0.98984024
86TP53_18474530_ChIP-ChIP_U2OS_Human0.98975205
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98945418
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98193566
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97895496
90* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97751707
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.97715356
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97589591
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97227872
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96850410
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96393507
96STAT3_23295773_ChIP-Seq_U87_Human0.96316140
97SMC4_20622854_ChIP-Seq_HELA_Human0.95766635
98CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95263812
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94479579
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.94350209
101TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93893171
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93660178
103EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92337000
104RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92337000
105CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92286088
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92163173
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92107874
108SMAD3_21741376_ChIP-Seq_EPCs_Human0.91832860
109GATA6_21074721_ChIP-Seq_CACO-2_Human0.91715633
110KDM2B_26808549_Chip-Seq_K562_Human0.91655170
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91159624
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.91124388
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90310489
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90057171
115* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89962372
116RNF2_27304074_Chip-Seq_ESCs_Mouse0.89849681
117GBX2_23144817_ChIP-Seq_PC3_Human0.89720419
118BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88766694
119MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88451626
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88322936
121RBPJ_21746931_ChIP-Seq_IB4_Human0.88135000
122PHF8_20622853_ChIP-Seq_HELA_Human0.87965940
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87944270
124CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87670623
125HNFA_21074721_ChIP-Seq_CACO-2_Human0.87245847
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87187385
127* AR_25329375_ChIP-Seq_VCAP_Human0.86539704
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.86153893
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85554839
130TBL1_22424771_ChIP-Seq_293T_Human0.85533747
131RXR_22108803_ChIP-Seq_LS180_Human0.85129772
132TCF4_23295773_ChIP-Seq_U87_Human0.84753009
133TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84692470
134SMRT_27268052_Chip-Seq_Bcells_Human0.83649355
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83201368
136RUNX2_22187159_ChIP-Seq_PCA_Human0.83085709
137EED_16625203_ChIP-ChIP_MESCs_Mouse0.82726135
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82051053
139NCOR_22424771_ChIP-Seq_293T_Human0.81911584
140ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81559405
141CTCF_20526341_ChIP-Seq_ESCs_Human0.81446902
142GATA4_25053715_ChIP-Seq_YYC3_Human0.80822479
143CTCF_27219007_Chip-Seq_Bcells_Human0.80676762
144EGR1_19032775_ChIP-ChIP_M12_Human0.80553796
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79777730
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79223112
147TP53_16413492_ChIP-PET_HCT116_Human0.77716549
148JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77682518
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.77479553
150NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76874731
151SUZ12_27294783_Chip-Seq_ESCs_Mouse0.75836922
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.73669694
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73504967
154* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73307875
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73255849
156GATA6_25053715_ChIP-Seq_YYC3_Human0.73000312
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71235728
158FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70482950
159SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.70162808
160TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69329777
161CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68897319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.29955051
2MP0002254_reproductive_system_inflammat5.05411985
3MP0005275_abnormal_skin_tensile5.03019884
4MP0004782_abnormal_surfactant_physiolog4.48303555
5MP0003705_abnormal_hypodermis_morpholog4.25112377
6MP0000579_abnormal_nail_morphology4.16122497
7MP0002653_abnormal_ependyma_morphology3.95993189
8MP0008875_abnormal_xenobiotic_pharmacok3.74698040
9MP0010234_abnormal_vibrissa_follicle3.59099691
10MP0002060_abnormal_skin_morphology3.49964784
11MP0008438_abnormal_cutaneous_collagen3.42347624
12MP0004043_abnormal_pH_regulation3.41905540
13MP0005501_abnormal_skin_physiology3.36587280
14MP0009780_abnormal_chondrocyte_physiolo3.03213123
15MP0003566_abnormal_cell_adhesion2.86387256
16MP0000762_abnormal_tongue_morphology2.70895930
17MP0003941_abnormal_skin_development2.68498285
18MP0001881_abnormal_mammary_gland2.62434498
19MP0005377_hearing/vestibular/ear_phenot2.60120686
20MP0003878_abnormal_ear_physiology2.60120686
21MP0001984_abnormal_olfaction2.59352743
22MP0001216_abnormal_epidermal_layer2.58458488
23MP0000383_abnormal_hair_follicle2.54944525
24MP0000467_abnormal_esophagus_morphology2.53980714
25MP0000427_abnormal_hair_cycle2.42810343
26MP0008995_early_reproductive_senescence2.32342100
27MP0010678_abnormal_skin_adnexa2.28551658
28MP0010771_integument_phenotype2.26426134
29MP0001849_ear_inflammation2.17333400
30MP0002098_abnormal_vibrissa_morphology2.15426268
31MP0004885_abnormal_endolymph2.14523524
32MP0003453_abnormal_keratinocyte_physiol2.13690332
33MP0000377_abnormal_hair_follicle2.11116457
34MP0004381_abnormal_hair_follicle2.08700693
35MP0000647_abnormal_sebaceous_gland1.81451667
36MP0004133_heterotaxia1.81000637
37MP0002132_abnormal_respiratory_system1.68861248
38MP0004272_abnormal_basement_membrane1.66272530
39MP0002876_abnormal_thyroid_physiology1.65169117
40MP0005503_abnormal_tendon_morphology1.64952616
41MP0002234_abnormal_pharynx_morphology1.63493082
42MP0004947_skin_inflammation1.62141576
43MP0005023_abnormal_wound_healing1.52992694
44MP0000627_abnormal_mammary_gland1.51502819
45MP0002277_abnormal_respiratory_mucosa1.50588647
46MP0005083_abnormal_biliary_tract1.50374548
47MP0003136_yellow_coat_color1.45072334
48MP0003950_abnormal_plasma_membrane1.42018893
49MP0009931_abnormal_skin_appearance1.37352182
50MP0004185_abnormal_adipocyte_glucose1.30503696
51MP0005409_darkened_coat_color1.30313590
52MP0001346_abnormal_lacrimal_gland1.28553090
53MP0001243_abnormal_dermal_layer1.26657600
54MP0003045_fibrosis1.25812052
55MP0002282_abnormal_trachea_morphology1.24996739
56MP0001851_eye_inflammation1.24596764
57MP0008004_abnormal_stomach_pH1.23756224
58MP0004264_abnormal_extraembryonic_tissu1.21313941
59MP0001485_abnormal_pinna_reflex1.19705539
60MP0002168_other_aberrant_phenotype1.18549124
61MP0000751_myopathy1.18181177
62MP0004019_abnormal_vitamin_homeostasis1.18022695
63MP0000681_abnormal_thyroid_gland1.18015964
64MP0010352_gastrointestinal_tract_polyps1.17838307
65MP0002909_abnormal_adrenal_gland1.16691016
66MP0001765_abnormal_ion_homeostasis1.16614739
67MP0005451_abnormal_body_composition1.13704501
68MP0000013_abnormal_adipose_tissue1.12440190
69MP0001191_abnormal_skin_condition1.11198225
70MP0005666_abnormal_adipose_tissue1.07701109
71MP0001958_emphysema1.05669745
72MP0002638_abnormal_pupillary_reflex1.04381707
73MP0006054_spinal_hemorrhage1.03402000
74MP0005551_abnormal_eye_electrophysiolog1.02341183
75MP0010030_abnormal_orbit_morphology1.01960844
76MP0000465_gastrointestinal_hemorrhage1.01008938
77MP0005375_adipose_tissue_phenotype1.00910395
78MP0008789_abnormal_olfactory_epithelium0.98617671
79MP0009384_cardiac_valve_regurgitation0.96290128
80MP0005508_abnormal_skeleton_morphology0.94627568
81MP0002877_abnormal_melanocyte_morpholog0.93610332
82MP0000678_abnormal_parathyroid_gland0.93374792
83MP0000749_muscle_degeneration0.91966948
84MP0002249_abnormal_larynx_morphology0.91051693
85MP0005623_abnormal_meninges_morphology0.90828779
86MP0000026_abnormal_inner_ear0.90066980
87MP0000367_abnormal_coat/_hair0.90016288
88MP0002896_abnormal_bone_mineralization0.88706940
89MP0009379_abnormal_foot_pigmentation0.88214483
90MP0001340_abnormal_eyelid_morphology0.86512477
91MP0002095_abnormal_skin_pigmentation0.86257970
92MP0001502_abnormal_circadian_rhythm0.85306562
93MP0003300_gastrointestinal_ulcer0.84491647
94MP0005076_abnormal_cell_differentiation0.83852990
95MP0003191_abnormal_cellular_cholesterol0.83552597
96MP0002837_dystrophic_cardiac_calcinosis0.83428755
97MP0000566_synostosis0.83087418
98MP0003011_delayed_dark_adaptation0.82361895
99MP0000750_abnormal_muscle_regeneration0.81162868
100MP0004130_abnormal_muscle_cell0.80305361
101MP0003279_aneurysm0.79044000
102MP0004883_abnormal_blood_vessel0.78279648
103MP0000538_abnormal_urinary_bladder0.77724675
104MP0003755_abnormal_palate_morphology0.76723799
105MP0009046_muscle_twitch0.75602071
106MP0001986_abnormal_taste_sensitivity0.75396506
107MP0000003_abnormal_adipose_tissue0.74239934
108MP0005257_abnormal_intraocular_pressure0.73411483
109MP0009643_abnormal_urine_homeostasis0.73156247
110MP0009250_abnormal_appendicular_skeleto0.72976627
111MP0003091_abnormal_cell_migration0.72045236
112MP0000631_abnormal_neuroendocrine_gland0.71106355
113MP0005253_abnormal_eye_physiology0.69648340
114MP0003448_altered_tumor_morphology0.68597975
115MP0001501_abnormal_sleep_pattern0.68087302
116MP0002136_abnormal_kidney_physiology0.67330740
117MP0005174_abnormal_tail_pigmentation0.67104529
118MP0003385_abnormal_body_wall0.65842148
119MP0005164_abnormal_response_to0.65402090
120MP0001188_hyperpigmentation0.65134660
121MP0001270_distended_abdomen0.64535264
122MP0002160_abnormal_reproductive_system0.63852515
123MP0005499_abnormal_olfactory_system0.63016828
124MP0005394_taste/olfaction_phenotype0.63016828
125MP0004742_abnormal_vestibular_system0.62605574
126MP0005330_cardiomyopathy0.61461412
127MP0000428_abnormal_craniofacial_morphol0.59499626
128MP0001177_atelectasis0.58601211
129MP0002177_abnormal_outer_ear0.58312183
130MP0001756_abnormal_urination0.57123352
131MP0003638_abnormal_response/metabolism_0.57106305
132MP0002108_abnormal_muscle_morphology0.56701667
133MP0001542_abnormal_bone_strength0.55855184
134MP0010368_abnormal_lymphatic_system0.54345288
135MP0004858_abnormal_nervous_system0.53993873
136MP0000432_abnormal_head_morphology0.53959522
137MP0002233_abnormal_nose_morphology0.53683313
138MP0001299_abnormal_eye_distance/0.52271273
139MP0003935_abnormal_craniofacial_develop0.51315771
140MP0000733_abnormal_muscle_development0.51176368
141MP0000759_abnormal_skeletal_muscle0.50977244
142MP0004087_abnormal_muscle_fiber0.50602996
143MP0003828_pulmonary_edema0.50434635
144MP0009053_abnormal_anal_canal0.50245481
145MP0008872_abnormal_physiological_respon0.49858699
146MP0002733_abnormal_thermal_nociception0.49371481
147MP0002133_abnormal_respiratory_system0.48653400
148MP0005388_respiratory_system_phenotype0.48653400
149MP0002269_muscular_atrophy0.48564579
150MP0000470_abnormal_stomach_morphology0.48262504
151MP0005395_other_phenotype0.46889166
152MP0001879_abnormal_lymphatic_vessel0.46271156
153MP0001790_abnormal_immune_system0.45870046
154MP0005387_immune_system_phenotype0.45870046
155MP0005636_abnormal_mineral_homeostasis0.45547300

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.67638704
2Abnormal respiratory epithelium morphology (HP:0012253)9.07260072
3Abnormal respiratory motile cilium morphology (HP:0005938)9.07260072
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.87391747
5Absent/shortened dynein arms (HP:0200106)8.87391747
6Abnormal respiratory motile cilium physiology (HP:0012261)8.67033208
7Abnormal ciliary motility (HP:0012262)8.64029286
8Rhinitis (HP:0012384)7.87767335
9Fragile nails (HP:0001808)6.74933584
10Chronic bronchitis (HP:0004469)6.74409795
11Milia (HP:0001056)6.53701498
12Atrophic scars (HP:0001075)6.26968509
13Plantar hyperkeratosis (HP:0007556)6.14749072
14Onycholysis (HP:0001806)6.04798234
15Bronchiectasis (HP:0002110)5.91583523
16Right ventricular cardiomyopathy (HP:0011663)5.86775942
17Abnormality of nail color (HP:0100643)5.39004437
18Pili torti (HP:0003777)5.30920989
19Nasal polyposis (HP:0100582)5.06459113
20Hypotrichosis (HP:0001006)4.91378716
21Abnormality of the nasal mucosa (HP:0000433)4.32324108
22Woolly hair (HP:0002224)4.16401624
23Palmoplantar hyperkeratosis (HP:0000972)4.15265214
24Thick nail (HP:0001805)4.13468134
25Nail dystrophy (HP:0008404)3.99403598
26Palmar hyperkeratosis (HP:0010765)3.93454940
27Fragile skin (HP:0001030)3.90113808
28Increased connective tissue (HP:0009025)3.88744066
29Hyporeflexia of lower limbs (HP:0002600)3.88036237
30Abnormal blistering of the skin (HP:0008066)3.87145535
31Distal lower limb muscle weakness (HP:0009053)3.76276410
32Premature rupture of membranes (HP:0001788)3.74771256
33Bronchitis (HP:0012387)3.61156786
34Increased IgE level (HP:0003212)3.59924393
35Interstitial pulmonary disease (HP:0006530)3.58254290
36Pancreatic fibrosis (HP:0100732)3.57341328
37Alopecia of scalp (HP:0002293)3.49782950
38True hermaphroditism (HP:0010459)3.49351495
39Hyperactive renin-angiotensin system (HP:0000841)3.46898118
40Abnormal hair laboratory examination (HP:0003328)3.42108509
41Chronic sinusitis (HP:0011109)3.30917432
42Erythema (HP:0010783)3.26234975
43Recurrent sinusitis (HP:0011108)3.23206175
44Pancreatic cysts (HP:0001737)3.19364562
45Type 1 muscle fiber predominance (HP:0003803)3.18641399
46Abnormality of midbrain morphology (HP:0002418)3.18257666
47Molar tooth sign on MRI (HP:0002419)3.18257666
48Infertility (HP:0000789)3.15071562
49Aplasia cutis congenita (HP:0001057)3.07752783
50Decreased circulating renin level (HP:0003351)3.02536693
51Recurrent otitis media (HP:0000403)3.02495702
52Cystic liver disease (HP:0006706)2.99505745
53Follicular hyperkeratosis (HP:0007502)2.95578070
54Occipital encephalocele (HP:0002085)2.94960918
55Nephronophthisis (HP:0000090)2.94262639
56Ectropion (HP:0000656)2.91168541
57Ridged nail (HP:0001807)2.90414356
58Advanced eruption of teeth (HP:0006288)2.89549259
59Natal tooth (HP:0000695)2.89511374
60Congenital ichthyosiform erythroderma (HP:0007431)2.85129152
61Ventricular tachycardia (HP:0004756)2.77862681
62Chronic hepatic failure (HP:0100626)2.67086517
63Furrowed tongue (HP:0000221)2.65952645
64Hypoplasia of dental enamel (HP:0006297)2.65161571
65Aortic dissection (HP:0002647)2.62823419
66Parakeratosis (HP:0001036)2.61859011
67Muscle fiber splitting (HP:0003555)2.60850468
68Cerebral aneurysm (HP:0004944)2.55510629
69Abnormality of the renal medulla (HP:0100957)2.53901657
70Protrusio acetabuli (HP:0003179)2.53719140
71Male infertility (HP:0003251)2.53603636
72Conjunctival hamartoma (HP:0100780)2.51489945
73Esophageal atresia (HP:0002032)2.51211386
74Ankle contracture (HP:0006466)2.49746817
75Chronic otitis media (HP:0000389)2.48279811
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.47669536
77Osteolytic defects of the hand bones (HP:0009699)2.47669536
78Distal lower limb amyotrophy (HP:0008944)2.43401000
79Abnormality of the axillary hair (HP:0100134)2.43207149
80Abnormality of secondary sexual hair (HP:0009888)2.43207149
81Acanthosis nigricans (HP:0000956)2.37676019
82Shallow orbits (HP:0000586)2.34003901
83Congenital hepatic fibrosis (HP:0002612)2.33804556
84Round ear (HP:0100830)2.33355556
85Renal salt wasting (HP:0000127)2.29931702
86Pterygium (HP:0001059)2.28916546
87Concave nail (HP:0001598)2.26085946
88Postaxial foot polydactyly (HP:0001830)2.25481455
89Scapular winging (HP:0003691)2.23956310
90Erythroderma (HP:0001019)2.20759836
91Tubular atrophy (HP:0000092)2.20580165
92Sparse eyelashes (HP:0000653)2.19635971
93Amelogenesis imperfecta (HP:0000705)2.18375468
94Atelectasis (HP:0100750)2.16730969
95Hyperkalemia (HP:0002153)2.16326304
96Palmoplantar keratoderma (HP:0000982)2.16249906
97Anonychia (HP:0001798)2.15254652
98Hypoplasia of the iris (HP:0007676)2.14648567
99Down-sloping shoulders (HP:0200021)2.11554186
100Tubulointerstitial nephritis (HP:0001970)2.10055698
101Curly hair (HP:0002212)2.09777253
102Spinal rigidity (HP:0003306)2.09135362
103Lip pit (HP:0100267)2.07310305
104Tubulointerstitial fibrosis (HP:0005576)2.06551413
105Increased variability in muscle fiber diameter (HP:0003557)2.05750438
106Aortic aneurysm (HP:0004942)2.03473240
107Abnormality of renin-angiotensin system (HP:0000847)2.01658417
108Broad metatarsal (HP:0001783)1.98780616
109Hypodontia (HP:0000668)1.98697629
110Abnormality of the renal collecting system (HP:0004742)1.97824803
111Hyperaldosteronism (HP:0000859)1.97010973
112Medial flaring of the eyebrow (HP:0010747)1.94829539
113Sudden death (HP:0001699)1.94436465
114Mildly elevated creatine phosphokinase (HP:0008180)1.93369644
115Bronchomalacia (HP:0002780)1.92272700
116Laryngomalacia (HP:0001601)1.92244062
117Abnormality of skeletal muscle fiber size (HP:0012084)1.88036915
118Difficulty running (HP:0009046)1.87552907
119Tachypnea (HP:0002789)1.87537923
120Oral leukoplakia (HP:0002745)1.87353493
121Anencephaly (HP:0002323)1.87041310
122Hypoplastic labia majora (HP:0000059)1.85496544
123Tubulointerstitial abnormality (HP:0001969)1.85153166
124Hamartoma of the eye (HP:0010568)1.84973521
125Cervical subluxation (HP:0003308)1.84624418
126Neonatal short-limb short stature (HP:0008921)1.84224509
127Corneal erosion (HP:0200020)1.82027758
128Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81777971
129Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81731811
130Thyroid-stimulating hormone excess (HP:0002925)1.81094414
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.80886673
132Thin bony cortex (HP:0002753)1.79874992
133Spondylolisthesis (HP:0003302)1.79653909
134Difficulty climbing stairs (HP:0003551)1.79621543
135Achilles tendon contracture (HP:0001771)1.78422475
136Muscle fiber inclusion bodies (HP:0100299)1.77877848
137Duplicated collecting system (HP:0000081)1.76550231
138Ureteral stenosis (HP:0000071)1.76251944
139Sparse lateral eyebrow (HP:0005338)1.76029288
140Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.75756974
141Male pseudohermaphroditism (HP:0000037)1.75149268
142Abnormality of the labia majora (HP:0012881)1.75058750
143Abnormality of the neuromuscular junction (HP:0003398)1.73948848
144Fatigable weakness (HP:0003473)1.73948848
145Elbow flexion contracture (HP:0002987)1.72622508
146Myopathic facies (HP:0002058)1.72052375
147Carious teeth (HP:0000670)1.69661568
148Hypohidrosis (HP:0000966)1.69629603
149Arterial tortuosity (HP:0005116)1.69427779
150Ulnar deviation of the wrist (HP:0003049)1.68992978
151Mitral valve prolapse (HP:0001634)1.66938233
152Abnormality of permanent molar morphology (HP:0011071)1.66596173
153Abnormality of the dental root (HP:0006486)1.66596173
154Taurodontia (HP:0000679)1.66596173
155Lower limb amyotrophy (HP:0007210)1.65548625
156Abnormality of the dental pulp (HP:0006479)1.64515918
157Decreased central vision (HP:0007663)1.64484123
158Nephropathy (HP:0000112)1.64296483
159Abnormality of chloride homeostasis (HP:0011422)1.63483962
160Gait imbalance (HP:0002141)1.63228962
161Hyperhidrosis (HP:0000975)1.63206044
162Aplasia/Hypoplasia of the spleen (HP:0010451)1.62696462
163Sclerocornea (HP:0000647)1.61703108
164Congenital primary aphakia (HP:0007707)1.61260649
165Nemaline bodies (HP:0003798)1.60053184
166Areflexia of lower limbs (HP:0002522)1.59923580
167Alveolar cell carcinoma (HP:0006519)1.59068731
168Dilatation of the ascending aorta (HP:0005111)1.58969823
169Vascular tortuosity (HP:0004948)1.57574706
170Renal dysplasia (HP:0000110)1.56019573
171Asplenia (HP:0001746)1.55035424
172Popliteal pterygium (HP:0009756)1.54474497
173Hypokalemic alkalosis (HP:0001949)1.53285581
174Abnormality of molar (HP:0011077)1.52359046
175Abnormality of molar morphology (HP:0011070)1.52359046
176Postaxial hand polydactyly (HP:0001162)1.49275690
177Abnormality of the renal cortex (HP:0011035)1.46599548
178Absent rod-and cone-mediated responses on ERG (HP:0007688)1.46472026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.34299458
2SIK14.78181938
3MAPKAPK33.80603570
4TTN3.60586321
5MST1R3.39934518
6LATS13.35601755
7ERN13.14486977
8FER3.01755753
9TRIB32.96349787
10MST42.91673563
11FRK2.79823910
12EPHB12.47986715
13PKN22.35974051
14PIK3CG2.29629496
15CAMK1D2.25247943
16TGFBR22.09537761
17RPS6KB22.06502054
18EPHB22.01227279
19EPHA32.00273161
20DDR21.96581426
21EEF2K1.96284652
22PIK3CA1.93144956
23EPHA21.91986476
24TRPM71.89188765
25RIPK11.75927660
26MAP3K61.63637115
27TLK11.61897854
28TGFBR11.60784525
29PTK61.59104428
30MET1.57408934
31MARK21.54380795
32GRK11.49830205
33INSRR1.48656724
34LATS21.42379482
35CAMK1G1.39686120
36PDGFRA1.39591609
37TAOK31.38874744
38ADRBK21.36927332
39MAP3K31.31968619
40LRRK21.24343060
41TXK1.22253255
42MAP4K21.17580489
43FGFR41.17488607
44PRKD11.12462627
45BMPR1B1.12429488
46PDK21.11928330
47CASK1.10684457
48FGFR21.09537730
49OBSCN1.03753453
50FGFR11.03367536
51BMX0.97516474
52AKT30.94025493
53PINK10.92332177
54ADRBK10.91437894
55MAPK130.91409095
56PDGFRB0.90395173
57PDK30.89931717
58PDK40.89931717
59MAP3K70.89021714
60PTK20.88169381
61MAP3K40.87815969
62PTK2B0.86682377
63SGK4940.84845146
64SGK2230.84845146
65MAP3K20.84703571
66NME20.83417793
67PAK20.82608116
68DMPK0.81507232
69MYLK0.78471825
70MAP3K10.78235987
71STK30.77799492
72WNK30.76880597
73STK38L0.76419207
74FGFR30.74633446
75WNK40.74364034
76CSK0.73745041
77ERBB30.72518567
78RET0.72228426
79MATK0.72170042
80SGK20.71278215
81MUSK0.69524913
82STK380.69476216
83PRKCI0.69189660
84PRKCE0.67180340
85CDC42BPA0.67117170
86NME10.65572461
87ILK0.64846215
88MAPK120.64818210
89ROCK10.63687707
90PHKG20.63401789
91PHKG10.63401789
92PRKAA20.57083542
93NEK60.55502726
94GSK3A0.55018299
95IRAK10.54476189
96SGK10.54404278
97HIPK20.54142920
98MAP2K10.54141279
99STK100.53912341
100MAPKAPK20.52848412
101CAMKK10.52567322
102MARK10.52533942
103MTOR0.52335920
104CDK60.50064827
105MAPK70.49620744
106NTRK30.49434833
107CDK120.49352062
108DAPK20.48035642
109TYRO30.47858742
110BCKDK0.47852395
111PRKCQ0.47329585
112OXSR10.47310311
113TESK10.47121321
114LIMK10.47023719
115NLK0.45326142
116STK110.45117918
117MAP2K70.44615736
118PBK0.44497804
119CHUK0.44495233
120EPHA40.43320670
121PRKD20.42580217
122ROCK20.41368164
123RPS6KA10.40817528
124ERBB20.39738000
125PRKCZ0.39593460
126RPS6KA20.39356661
127PNCK0.38759187
128RPS6KA40.37867283
129PRKCA0.37602311
130MAP2K40.37249012
131MAP2K30.36902193
132TAOK10.36641979
133* PRKACA0.35596502
134PRKCD0.35255146
135IKBKB0.34616665
136TIE10.34264887
137TBK10.34209146
138TYK20.34208300
139SGK30.34145855
140ABL10.34014626
141PRKCH0.33691385
142BCR0.33073406
143MARK30.32534142
144KIT0.31312740
145MAPKAPK50.30521721
146GRK70.30443284
147CAMKK20.29169763
148MAP2K60.28644784
149HCK0.28001848
150PAK40.27478896
151IRAK20.26366158
152MAP2K20.25396759
153SRC0.25315763
154STK240.23421176
155RPS6KC10.22288960
156RPS6KL10.22288960
157JAK10.21162675
158MAPK110.20148427
159IGF1R0.18400792
160PAK30.17653008

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.59658688
2Fatty acid biosynthesis_Homo sapiens_hsa000615.02961598
3ECM-receptor interaction_Homo sapiens_hsa045123.38389763
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.03298807
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.86173964
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.76011068
7Chemical carcinogenesis_Homo sapiens_hsa052042.64560123
8Tyrosine metabolism_Homo sapiens_hsa003502.21379530
9ABC transporters_Homo sapiens_hsa020102.12366814
10Phototransduction_Homo sapiens_hsa047442.11985897
11Ether lipid metabolism_Homo sapiens_hsa005652.11544032
12Amoebiasis_Homo sapiens_hsa051462.09220937
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.07780388
14beta-Alanine metabolism_Homo sapiens_hsa004101.99182883
15Focal adhesion_Homo sapiens_hsa045101.91338100
16Basal cell carcinoma_Homo sapiens_hsa052171.90127670
17Dilated cardiomyopathy_Homo sapiens_hsa054141.87509545
18Proteoglycans in cancer_Homo sapiens_hsa052051.78284863
19Retinol metabolism_Homo sapiens_hsa008301.70456509
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70114360
21Adherens junction_Homo sapiens_hsa045201.66701474
22Tight junction_Homo sapiens_hsa045301.60778483
23Hippo signaling pathway_Homo sapiens_hsa043901.51254485
24Ovarian steroidogenesis_Homo sapiens_hsa049131.46637962
25Small cell lung cancer_Homo sapiens_hsa052221.40083266
26Fatty acid metabolism_Homo sapiens_hsa012121.39841587
27Protein digestion and absorption_Homo sapiens_hsa049741.37417712
28Galactose metabolism_Homo sapiens_hsa000521.36020147
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.33308474
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.32333080
31Circadian rhythm_Homo sapiens_hsa047101.30369853
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24393918
33Fatty acid elongation_Homo sapiens_hsa000621.24157895
34Taste transduction_Homo sapiens_hsa047421.20860543
35TGF-beta signaling pathway_Homo sapiens_hsa043501.20121446
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.18441536
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17553260
38Hedgehog signaling pathway_Homo sapiens_hsa043401.15379857
39PPAR signaling pathway_Homo sapiens_hsa033201.13639617
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11247340
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09860841
42Toxoplasmosis_Homo sapiens_hsa051451.07592634
43Insulin resistance_Homo sapiens_hsa049311.07112618
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06187020
45Serotonergic synapse_Homo sapiens_hsa047261.05751768
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05496171
47Malaria_Homo sapiens_hsa051441.02203411
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01974278
49Melanogenesis_Homo sapiens_hsa049161.00611385
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98860473
51PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98537213
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96771213
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96439842
54Olfactory transduction_Homo sapiens_hsa047400.95348941
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95073161
56Nicotine addiction_Homo sapiens_hsa050330.94686095
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.93787906
58Arachidonic acid metabolism_Homo sapiens_hsa005900.93764575
59Propanoate metabolism_Homo sapiens_hsa006400.93747955
60Tryptophan metabolism_Homo sapiens_hsa003800.93655419
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.92520557
62AMPK signaling pathway_Homo sapiens_hsa041520.91998347
63Nitrogen metabolism_Homo sapiens_hsa009100.91705941
64VEGF signaling pathway_Homo sapiens_hsa043700.91192360
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90809160
66Insulin signaling pathway_Homo sapiens_hsa049100.89465841
67Bladder cancer_Homo sapiens_hsa052190.88840174
68Salmonella infection_Homo sapiens_hsa051320.86095876
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84800332
70Axon guidance_Homo sapiens_hsa043600.83659452
71Prolactin signaling pathway_Homo sapiens_hsa049170.82327743
72Huntingtons disease_Homo sapiens_hsa050160.82016125
73Ribosome_Homo sapiens_hsa030100.81868014
74MicroRNAs in cancer_Homo sapiens_hsa052060.81534967
75Mineral absorption_Homo sapiens_hsa049780.81367311
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80751384
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.80611739
78Fatty acid degradation_Homo sapiens_hsa000710.80040063
79Acute myeloid leukemia_Homo sapiens_hsa052210.79396038
80Chronic myeloid leukemia_Homo sapiens_hsa052200.79114285
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78337737
82Glutamatergic synapse_Homo sapiens_hsa047240.78162738
83Fat digestion and absorption_Homo sapiens_hsa049750.75830061
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.75743182
85Choline metabolism in cancer_Homo sapiens_hsa052310.75302040
86GnRH signaling pathway_Homo sapiens_hsa049120.74113966
87Pathways in cancer_Homo sapiens_hsa052000.73525509
88Sphingolipid metabolism_Homo sapiens_hsa006000.73482285
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72500750
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72104359
91Linoleic acid metabolism_Homo sapiens_hsa005910.70997106
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70329326
93Rap1 signaling pathway_Homo sapiens_hsa040150.69665510
94Complement and coagulation cascades_Homo sapiens_hsa046100.66760494
95Pancreatic cancer_Homo sapiens_hsa052120.66294663
96Glutathione metabolism_Homo sapiens_hsa004800.65941477
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.65905033
98Platelet activation_Homo sapiens_hsa046110.65685573
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.65173858
100Hepatitis C_Homo sapiens_hsa051600.64432981
101Peroxisome_Homo sapiens_hsa041460.63950028
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63231678
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.62742181
104Glycerolipid metabolism_Homo sapiens_hsa005610.62016410
105Viral myocarditis_Homo sapiens_hsa054160.60444425
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59905396
107Staphylococcus aureus infection_Homo sapiens_hsa051500.59201767
108Ras signaling pathway_Homo sapiens_hsa040140.59117833
109Autoimmune thyroid disease_Homo sapiens_hsa053200.56698345
110Circadian entrainment_Homo sapiens_hsa047130.55519972
111cAMP signaling pathway_Homo sapiens_hsa040240.53154887
112Pertussis_Homo sapiens_hsa051330.52706810
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52233762
114Glucagon signaling pathway_Homo sapiens_hsa049220.51973302
115Gastric acid secretion_Homo sapiens_hsa049710.51855714
116Tuberculosis_Homo sapiens_hsa051520.51836367
117Salivary secretion_Homo sapiens_hsa049700.51656897
118Long-term depression_Homo sapiens_hsa047300.51497356
119Wnt signaling pathway_Homo sapiens_hsa043100.50917875
120Renal cell carcinoma_Homo sapiens_hsa052110.50425523
121Histidine metabolism_Homo sapiens_hsa003400.50424605
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50136424
123Calcium signaling pathway_Homo sapiens_hsa040200.49095456
124Renin secretion_Homo sapiens_hsa049240.48240599
125Graft-versus-host disease_Homo sapiens_hsa053320.47792481
126Pancreatic secretion_Homo sapiens_hsa049720.47760855
127Phenylalanine metabolism_Homo sapiens_hsa003600.47212218
128Osteoclast differentiation_Homo sapiens_hsa043800.46325945
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41341286
130Asthma_Homo sapiens_hsa053100.40920899
131Estrogen signaling pathway_Homo sapiens_hsa049150.40834393
132Collecting duct acid secretion_Homo sapiens_hsa049660.40585415
133Bile secretion_Homo sapiens_hsa049760.40441258
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40389012
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40259062
136Melanoma_Homo sapiens_hsa052180.39632075
137ErbB signaling pathway_Homo sapiens_hsa040120.38537094
138Allograft rejection_Homo sapiens_hsa053300.38300056
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37954195
140Amphetamine addiction_Homo sapiens_hsa050310.36390494
141Dorso-ventral axis formation_Homo sapiens_hsa043200.35702564
142Oxytocin signaling pathway_Homo sapiens_hsa049210.35624912
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.35621613
144Endometrial cancer_Homo sapiens_hsa052130.35257406
145Insulin secretion_Homo sapiens_hsa049110.35196349
146Phagosome_Homo sapiens_hsa041450.34403927
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34360121
148Thyroid hormone synthesis_Homo sapiens_hsa049180.34110684
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33792309
150Glioma_Homo sapiens_hsa052140.33595087
151Notch signaling pathway_Homo sapiens_hsa043300.33426568
152Lysosome_Homo sapiens_hsa041420.33333652
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33004854
154Butanoate metabolism_Homo sapiens_hsa006500.32268377
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.31614567
156Endocytosis_Homo sapiens_hsa041440.31261534
157TNF signaling pathway_Homo sapiens_hsa046680.30927521
158Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30158356
159Apoptosis_Homo sapiens_hsa042100.29564782
160Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29406306
161Hematopoietic cell lineage_Homo sapiens_hsa046400.27920600

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