DUOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.82209524
2intestinal cholesterol absorption (GO:0030299)9.72345607
3angiotensin maturation (GO:0002003)8.39576094
4maintenance of gastrointestinal epithelium (GO:0030277)7.65683813
5positive regulation of respiratory burst (GO:0060267)7.31669451
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.56177417
7hemidesmosome assembly (GO:0031581)6.02378798
8bile acid and bile salt transport (GO:0015721)5.93318510
9epithelial structure maintenance (GO:0010669)5.90075154
10virion attachment to host cell (GO:0019062)5.89979255
11adhesion of symbiont to host cell (GO:0044650)5.89979255
12complement activation, classical pathway (GO:0006958)5.84638673
13regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.72570061
14actin filament depolymerization (GO:0030042)5.68434273
15digestive system process (GO:0022600)5.59409976
16regulation of cellular extravasation (GO:0002691)5.50456375
17glomerular filtration (GO:0003094)5.37090480
18vitamin A metabolic process (GO:0006776)5.28907766
19regulation of RIG-I signaling pathway (GO:0039535)5.24047348
20antibacterial humoral response (GO:0019731)5.21278571
21antimicrobial humoral response (GO:0019730)5.11323106
22UDP-N-acetylglucosamine metabolic process (GO:0006047)5.10650324
23renal filtration (GO:0097205)5.02348870
24regulation of respiratory burst (GO:0060263)4.90886125
25regulation of bile acid biosynthetic process (GO:0070857)4.84164860
26adhesion of symbiont to host (GO:0044406)4.79579203
27O-glycan processing (GO:0016266)4.74015431
28complement activation (GO:0006956)4.64859918
29positive regulation of pseudopodium assembly (GO:0031274)4.55952944
30regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.44286348
31regulation of viral release from host cell (GO:1902186)4.36397583
32intestinal epithelial cell development (GO:0060576)4.34119525
33modified amino acid transport (GO:0072337)4.30916065
34glucocorticoid biosynthetic process (GO:0006704)4.30050990
35drug catabolic process (GO:0042737)4.26208366
36regulation of guanylate cyclase activity (GO:0031282)4.19718605
37cGMP-mediated signaling (GO:0019934)4.08462367
38regulation of pseudopodium assembly (GO:0031272)4.06940404
39arginine catabolic process (GO:0006527)4.03176796
40hepatocyte apoptotic process (GO:0097284)3.90363425
41digestion (GO:0007586)3.89906249
423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.84029232
43purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.84029232
44transcytosis (GO:0045056)3.80405933
45cellular response to hepatocyte growth factor stimulus (GO:0035729)3.79635380
46response to hepatocyte growth factor (GO:0035728)3.79635380
47oligosaccharide biosynthetic process (GO:0009312)3.78187268
48flavonoid metabolic process (GO:0009812)3.74455313
49desmosome organization (GO:0002934)3.72393341
50diacylglycerol metabolic process (GO:0046339)3.68716026
51cobalamin metabolic process (GO:0009235)3.65664076
52fucose catabolic process (GO:0019317)3.64625131
53L-fucose metabolic process (GO:0042354)3.64625131
54L-fucose catabolic process (GO:0042355)3.64625131
55sulfation (GO:0051923)3.63418913
56glucose 6-phosphate metabolic process (GO:0051156)3.62551626
57drinking behavior (GO:0042756)3.62099938
58thrombin receptor signaling pathway (GO:0070493)3.58256932
59protein activation cascade (GO:0072376)3.57877632
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.53558789
61peptide catabolic process (GO:0043171)3.52272191
62regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.51103494
63arginine metabolic process (GO:0006525)3.50462610
64defense response to fungus (GO:0050832)3.49957522
65sulfate transmembrane transport (GO:1902358)3.47763395
66sulfur compound transport (GO:0072348)3.46214735
67lipoprotein metabolic process (GO:0042157)3.43527892
68regulation of cholesterol homeostasis (GO:2000188)3.40762370
69striated muscle atrophy (GO:0014891)3.39034712
70positive regulation of glycoprotein biosynthetic process (GO:0010560)3.37057765
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.35802810
72positive regulation of guanylate cyclase activity (GO:0031284)3.33665380
73ventricular cardiac muscle cell action potential (GO:0086005)3.31571576
74phosphatidylserine acyl-chain remodeling (GO:0036150)3.28750612
75positive regulation of glycoprotein metabolic process (GO:1903020)3.20205153
76plasma lipoprotein particle assembly (GO:0034377)3.19489335
77phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.17644451
78phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.17171735
79chronic inflammatory response (GO:0002544)3.16679646
80innate immune response in mucosa (GO:0002227)3.16605755
81protein-lipid complex assembly (GO:0065005)3.16274918
82peptide hormone processing (GO:0016486)3.14232416
83phospholipid efflux (GO:0033700)3.11381972
84regulation of transforming growth factor beta1 production (GO:0032908)3.11051049
85negative regulation of sterol transport (GO:0032372)3.10508925
86negative regulation of cholesterol transport (GO:0032375)3.10508925
87triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.06528313
88uronic acid metabolic process (GO:0006063)3.06136258
89glucuronate metabolic process (GO:0019585)3.06136258
90cell communication involved in cardiac conduction (GO:0086065)3.04473038
91sterol homeostasis (GO:0055092)3.01854495
92negative regulation of protein tyrosine kinase activity (GO:0061099)3.01849269
93lipoprotein transport (GO:0042953)3.01294425
94cholesterol homeostasis (GO:0042632)3.01061154
95regulation of cholesterol esterification (GO:0010872)3.00679445
96pyrimidine-containing compound transmembrane transport (GO:0072531)3.00135738
97killing of cells of other organism (GO:0031640)2.99818721
98disruption of cells of other organism (GO:0044364)2.99818721
99antigen processing and presentation of endogenous antigen (GO:0019883)2.99563323
100GDP-mannose metabolic process (GO:0019673)2.98856541
101calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.97851771
102phosphatidylcholine biosynthetic process (GO:0006656)2.96574402
103regulation of actin nucleation (GO:0051125)2.95697099
104amyloid precursor protein catabolic process (GO:0042987)2.95568002
105cellular glucuronidation (GO:0052695)2.94761993
106skeletal muscle adaptation (GO:0043501)2.94458953
107positive regulation of lipoprotein lipase activity (GO:0051006)2.92953791
108positive regulation of triglyceride lipase activity (GO:0061365)2.92953791
109positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.92874424
110protein O-linked glycosylation (GO:0006493)2.92699074
111humoral immune response (GO:0006959)2.92449535
112activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.91324619
113regulation of triglyceride catabolic process (GO:0010896)2.90862351
114eosinophil chemotaxis (GO:0048245)2.90263945
115cholesterol transport (GO:0030301)2.83449669
116sterol transport (GO:0015918)2.83449669
117sphingomyelin metabolic process (GO:0006684)2.83213586
118phosphatidylinositol acyl-chain remodeling (GO:0036149)2.81621325
119transepithelial transport (GO:0070633)2.80792778
120regulation of systemic arterial blood pressure (GO:0003073)2.79876973
121mucosal immune response (GO:0002385)2.79690194
122muscle atrophy (GO:0014889)2.79336071
123positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.78382437
124negative regulation of viral release from host cell (GO:1902187)2.77448898
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.75878562
126regulation of proton transport (GO:0010155)2.74719731
127response to hydroperoxide (GO:0033194)2.74452961
128regulation of T cell tolerance induction (GO:0002664)2.74277923
129cholesterol efflux (GO:0033344)2.73929143
130regulation of viral entry into host cell (GO:0046596)2.73628549
131urea cycle (GO:0000050)2.73336507
132glucocorticoid metabolic process (GO:0008211)2.72609250
133fucosylation (GO:0036065)2.72546744
134purine nucleotide salvage (GO:0032261)2.72179313
135sulfate transport (GO:0008272)2.70916863
136nucleotide-sugar biosynthetic process (GO:0009226)2.70491464
137protein neddylation (GO:0045116)2.69789592
138regulation of cGMP biosynthetic process (GO:0030826)2.69556485
139negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.69272691
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.69209809
141regulation of systemic arterial blood pressure by hormone (GO:0001990)2.68703076
142regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.68703076
143endocrine process (GO:0050886)2.68703076
144filopodium assembly (GO:0046847)2.68680086
145acute-phase response (GO:0006953)2.67927526
146regulation of vitamin metabolic process (GO:0030656)2.67564872
147positive regulation of vasodilation (GO:0045909)2.65716655
148ethanol oxidation (GO:0006069)2.63500061
149low-density lipoprotein particle remodeling (GO:0034374)2.62780099
150retina homeostasis (GO:0001895)2.60028156
151auditory receptor cell differentiation (GO:0042491)2.58555166
152glutathione biosynthetic process (GO:0006750)2.58239585
153urea metabolic process (GO:0019627)2.56258457
154eosinophil migration (GO:0072677)2.55922942
155androgen biosynthetic process (GO:0006702)2.54364671
156membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.52035825
157negative regulation of protein activation cascade (GO:2000258)2.51847114
158nonribosomal peptide biosynthetic process (GO:0019184)2.48909579
159regulation of metalloenzyme activity (GO:0048552)2.48765364
160hormone catabolic process (GO:0042447)2.48693021
161phosphatidylserine metabolic process (GO:0006658)2.48405317
162negative regulation of hormone metabolic process (GO:0032351)2.48331932
163Golgi transport vesicle coating (GO:0048200)2.48199337
164COPI coating of Golgi vesicle (GO:0048205)2.48199337
165regulation of protein activation cascade (GO:2000257)2.46829537
166regulation of complement activation (GO:0030449)2.45596467
167negative regulation of epidermal cell differentiation (GO:0045605)2.44484022
168progesterone metabolic process (GO:0042448)2.43717654
169nitric oxide biosynthetic process (GO:0006809)2.43396872
170regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.40529534
171regulation of keratinocyte proliferation (GO:0010837)2.40326231
172renal system process involved in regulation of blood volume (GO:0001977)2.40279820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.34127134
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.96247332
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.45385507
4GATA4_25053715_ChIP-Seq_YYC3_Human2.88229882
5SOX2_20726797_ChIP-Seq_SW620_Human2.81789194
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72230279
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.62706457
8GATA6_25053715_ChIP-Seq_YYC3_Human2.62413851
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38797822
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.37672423
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34353717
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.32799846
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08637551
14PPAR_26484153_Chip-Seq_NCI-H1993_Human2.03135165
15KLF5_25053715_ChIP-Seq_YYC3_Human1.99699876
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98919670
17PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95906389
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.95044953
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.86954654
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.81913953
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.81467607
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.80650320
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74246697
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.74099852
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73659463
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.69943218
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.69269818
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68130707
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.64837664
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63301154
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58456100
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57670716
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53389668
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50814551
35RACK7_27058665_Chip-Seq_MCF-7_Human1.50676844
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50391079
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49879212
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.47191241
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42471799
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42169796
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39989969
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39442742
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39088289
44ATF3_27146783_Chip-Seq_COLON_Human1.36434989
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.36340777
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35345814
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34820455
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34536775
49FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31656097
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31413877
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30847878
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30229341
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30229341
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30163250
55CLOCK_20551151_ChIP-Seq_293T_Human1.29992756
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29646130
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29208392
58GATA2_19941826_ChIP-Seq_K562_Human1.27855978
59ZNF263_19887448_ChIP-Seq_K562_Human1.27078397
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23277504
61JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23033954
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19074619
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18971879
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14558743
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13071388
66DROSHA_22980978_ChIP-Seq_HELA_Human1.07249574
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.05385081
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04038683
69HNF4A_19822575_ChIP-Seq_HepG2_Human1.00695973
70CREB1_26743006_Chip-Seq_LNCaP_Human1.00223521
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99250397
72CDX2_22108803_ChIP-Seq_LS180_Human0.97607956
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97027374
74AR_21909140_ChIP-Seq_LNCAP_Human0.96393388
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95627653
76BCAT_22108803_ChIP-Seq_LS180_Human0.95609737
77* LXR_22292898_ChIP-Seq_THP-1_Human0.95461557
78EGR1_19032775_ChIP-ChIP_M12_Human0.95417271
79P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94442868
80TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94286326
81FOXA1_25552417_ChIP-Seq_VCAP_Human0.93461186
82BP1_19119308_ChIP-ChIP_Hs578T_Human0.92481373
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92347718
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91668360
85IRF8_21731497_ChIP-ChIP_J774_Mouse0.90977310
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.90808229
87GATA3_24758297_ChIP-Seq_MCF-7_Human0.90465178
88SMAD3_21741376_ChIP-Seq_HESCs_Human0.90280226
89GATA1_19941826_ChIP-Seq_K562_Human0.90151553
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89789789
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87963131
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87676385
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87666230
94P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86896749
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86565629
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86038489
97CJUN_26792858_Chip-Seq_BT549_Human0.85649729
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83276418
99AHR_22903824_ChIP-Seq_MCF-7_Human0.82114702
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81205621
101RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80333843
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80089474
103* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79327637
104IRF8_27001747_Chip-Seq_BMDM_Mouse0.79198454
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79023043
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78470982
107RXR_22108803_ChIP-Seq_LS180_Human0.77719719
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77714028
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77559274
110* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77125664
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76945767
112EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76767233
113TP63_23658742_ChIP-Seq_EP156T_Human0.75876250
114CEBPB_22108803_ChIP-Seq_LS180_Human0.75829036
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73528874
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73425564
117* TP63_22573176_ChIP-Seq_HFKS_Human0.73029042
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72551457
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69565054
120FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69117838
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68965318
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.68376511
123JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.67504859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.37566742
2MP0010234_abnormal_vibrissa_follicle7.36270989
3MP0001666_abnormal_nutrient_absorption5.07214898
4MP0004264_abnormal_extraembryonic_tissu4.59866351
5MP0005085_abnormal_gallbladder_physiolo3.27678788
6MP0003183_abnormal_peptide_metabolism2.98471052
7MP0000462_abnormal_digestive_system2.90035980
8MP0003866_abnormal_defecation2.78026053
9MP0000537_abnormal_urethra_morphology2.50570232
10MP0003252_abnormal_bile_duct2.48246224
11MP0002138_abnormal_hepatobiliary_system2.34303684
12MP0003724_increased_susceptibility_to2.29133330
13MP0009840_abnormal_foam_cell2.27357841
14MP0001664_abnormal_digestion2.18585058
15MP0002139_abnormal_hepatobiliary_system2.18234505
16MP0000538_abnormal_urinary_bladder2.17087600
17MP0003705_abnormal_hypodermis_morpholog2.11992768
18MP0010155_abnormal_intestine_physiology2.10091699
19MP0000465_gastrointestinal_hemorrhage2.04595710
20MP0001663_abnormal_digestive_system2.01557715
21MP0005381_digestive/alimentary_phenotyp1.95164784
22MP0001873_stomach_inflammation1.94690210
23MP0010352_gastrointestinal_tract_polyps1.94271522
24MP0005365_abnormal_bile_salt1.94168289
25MP0010329_abnormal_lipoprotein_level1.93215491
26MP0006054_spinal_hemorrhage1.88375293
27MP0010678_abnormal_skin_adnexa1.87303519
28MP0001849_ear_inflammation1.84552169
29MP0004147_increased_porphyrin_level1.78394817
30MP0008004_abnormal_stomach_pH1.65835438
31MP0000477_abnormal_intestine_morphology1.64167379
32MP0001756_abnormal_urination1.52148743
33MP0002796_impaired_skin_barrier1.51324470
34MP0010386_abnormal_urinary_bladder1.51183160
35MP0003436_decreased_susceptibility_to1.48415562
36MP0005409_darkened_coat_color1.48180385
37MP0005084_abnormal_gallbladder_morpholo1.46093040
38* MP0002876_abnormal_thyroid_physiology1.42602573
39MP0005083_abnormal_biliary_tract1.41515905
40MP0008875_abnormal_xenobiotic_pharmacok1.40929165
41MP0000490_abnormal_crypts_of1.40505546
42MP0005387_immune_system_phenotype1.38623777
43MP0001790_abnormal_immune_system1.38623777
44MP0004947_skin_inflammation1.34123968
45MP0003300_gastrointestinal_ulcer1.31352463
46MP0004019_abnormal_vitamin_homeostasis1.31204966
47MP0000678_abnormal_parathyroid_gland1.29961187
48MP0003453_abnormal_keratinocyte_physiol1.27502309
49MP0001533_abnormal_skeleton_physiology1.27184914
50MP0000604_amyloidosis1.24647478
51MP0003806_abnormal_nucleotide_metabolis1.21022408
52MP0009379_abnormal_foot_pigmentation1.19932401
53MP0004858_abnormal_nervous_system1.19899589
54MP0005377_hearing/vestibular/ear_phenot1.18300155
55MP0003878_abnormal_ear_physiology1.18300155
56MP0009643_abnormal_urine_homeostasis1.16807788
57MP0005310_abnormal_salivary_gland1.15690317
58MP0005025_abnormal_response_to1.15383218
59MP0003191_abnormal_cellular_cholesterol1.13069982
60MP0002822_catalepsy1.09962486
61MP0005501_abnormal_skin_physiology1.09508779
62MP0005166_decreased_susceptibility_to1.07953990
63MP0003329_amyloid_beta_deposits1.07675918
64MP0002166_altered_tumor_susceptibility1.03449447
65MP0002896_abnormal_bone_mineralization1.02688637
66MP0000470_abnormal_stomach_morphology0.99675769
67MP0001216_abnormal_epidermal_layer0.99444722
68MP0005167_abnormal_blood-brain_barrier0.99420358
69MP0002277_abnormal_respiratory_mucosa0.97461601
70MP0004043_abnormal_pH_regulation0.97274447
71MP0005448_abnormal_energy_balance0.95899017
72MP0003868_abnormal_feces_composition0.92473158
73MP0002098_abnormal_vibrissa_morphology0.91414653
74MP0004782_abnormal_surfactant_physiolog0.90572221
75MP0001765_abnormal_ion_homeostasis0.90568771
76MP0000467_abnormal_esophagus_morphology0.90383500
77MP0005332_abnormal_amino_acid0.88602495
78MP0001764_abnormal_homeostasis0.85801281
79MP0002006_tumorigenesis0.84565550
80MP0004270_analgesia0.83575215
81MP0005584_abnormal_enzyme/coenzyme_acti0.83114852
82MP0005058_abnormal_lysosome_morphology0.82871900
83MP0008469_abnormal_protein_level0.82813836
84MP0001835_abnormal_antigen_presentation0.81822927
85MP0003303_peritoneal_inflammation0.81368840
86MP0002118_abnormal_lipid_homeostasis0.81137031
87MP0000609_abnormal_liver_physiology0.79766417
88MP0009780_abnormal_chondrocyte_physiolo0.78670337
89MP0005164_abnormal_response_to0.77762348
90MP0000516_abnormal_urinary_system0.77298148
91MP0005367_renal/urinary_system_phenotyp0.77298148
92MP0002148_abnormal_hypersensitivity_rea0.77060095
93MP0005464_abnormal_platelet_physiology0.77055162
94MP0000685_abnormal_immune_system0.76842135
95MP0002060_abnormal_skin_morphology0.75932710
96MP0000566_synostosis0.75555127
97MP0002998_abnormal_bone_remodeling0.75434565
98MP0002909_abnormal_adrenal_gland0.75393839
99MP0002254_reproductive_system_inflammat0.75208590
100MP0005023_abnormal_wound_healing0.74706330
101MP0010307_abnormal_tumor_latency0.74311016
102MP0008775_abnormal_heart_ventricle0.74231961
103MP0009785_altered_susceptibility_to0.73961298
104MP0002132_abnormal_respiratory_system0.73957729
105MP0003075_altered_response_to0.72901442
106MP0005319_abnormal_enzyme/_coenzyme0.72444250
107MP0002089_abnormal_postnatal_growth/wei0.71969771
108MP0006082_CNS_inflammation0.70922001
109MP0002136_abnormal_kidney_physiology0.70537807
110MP0003315_abnormal_perineum_morphology0.69981561
111MP0008872_abnormal_physiological_respon0.69418400
112MP0000383_abnormal_hair_follicle0.69082883
113MP0000249_abnormal_blood_vessel0.68237267
114MP0000377_abnormal_hair_follicle0.67937207
115MP0001881_abnormal_mammary_gland0.67254632
116MP0005451_abnormal_body_composition0.66639873
117MP0005636_abnormal_mineral_homeostasis0.66376645
118MP0000427_abnormal_hair_cycle0.64615574
119MP0009053_abnormal_anal_canal0.64439734
120MP0003045_fibrosis0.64082380
121MP0002234_abnormal_pharynx_morphology0.63406285
122MP0010771_integument_phenotype0.61972012
123MP0005248_abnormal_Harderian_gland0.58312642
124MP0009384_cardiac_valve_regurgitation0.57477340
125MP0004272_abnormal_basement_membrane0.55857880
126MP0003566_abnormal_cell_adhesion0.53607499
127MP0003283_abnormal_digestive_organ0.52675362
128MP0001845_abnormal_inflammatory_respons0.52243518
129MP0003950_abnormal_plasma_membrane0.51960721
130MP0005275_abnormal_skin_tensile0.51804425
131MP0005187_abnormal_penis_morphology0.50662810
132MP0001501_abnormal_sleep_pattern0.49104673
133MP0000579_abnormal_nail_morphology0.48752072
134MP0005165_increased_susceptibility_to0.47843179

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.50919715
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.88353231
3Ileus (HP:0002595)6.68915954
4Onycholysis (HP:0001806)6.05432521
5Milia (HP:0001056)5.53405137
6Abnormality of proline metabolism (HP:0010907)5.35739356
7Hydroxyprolinuria (HP:0003080)5.35739356
8Fragile nails (HP:0001808)4.98200661
9Atrophic scars (HP:0001075)4.98095021
10Systemic lupus erythematosus (HP:0002725)4.91726606
11Malnutrition (HP:0004395)4.31552031
12Steatorrhea (HP:0002570)4.09126407
13Exocrine pancreatic insufficiency (HP:0001738)4.08507862
14Autoimmune thrombocytopenia (HP:0001973)4.08489152
15Pustule (HP:0200039)3.99025346
16Glomerulonephritis (HP:0000099)3.91593268
17Decreased circulating renin level (HP:0003351)3.90541960
18Acanthocytosis (HP:0001927)3.89830678
19Pili torti (HP:0003777)3.86981496
20Conjugated hyperbilirubinemia (HP:0002908)3.86326306
21Chronic diarrhea (HP:0002028)3.84806329
22Cupped ribs (HP:0000887)3.65785250
23Abdominal distention (HP:0003270)3.52921600
24Hypobetalipoproteinemia (HP:0003563)3.50805476
25Complement deficiency (HP:0004431)3.50586754
26Mildly elevated creatine phosphokinase (HP:0008180)3.43920639
27Villous atrophy (HP:0011473)3.43598413
28Abnormality of small intestinal villus morphology (HP:0011472)3.43598413
29Fat malabsorption (HP:0002630)3.38363735
30Abnormality of renin-angiotensin system (HP:0000847)3.36085381
31Abnormality of complement system (HP:0005339)3.35701237
32Plantar hyperkeratosis (HP:0007556)3.34506662
33* Goiter (HP:0000853)3.26131903
34Palpitations (HP:0001962)3.20045471
35Nephritis (HP:0000123)3.19086085
36Flat acetabular roof (HP:0003180)3.12888175
37Woolly hair (HP:0002224)3.12586718
38Myopathic facies (HP:0002058)3.02627404
39Autoimmune hemolytic anemia (HP:0001890)2.98245604
40Abnormal tarsal ossification (HP:0008369)2.98230824
41Micronodular cirrhosis (HP:0001413)2.95196655
42Alkalosis (HP:0001948)2.94241046
43Progressive sensorineural hearing impairment (HP:0000408)2.90214478
44Dehydration (HP:0001944)2.84474309
45Curly hair (HP:0002212)2.69077556
46Ureteral stenosis (HP:0000071)2.67669214
47Vascular calcification (HP:0004934)2.66258944
48Renal salt wasting (HP:0000127)2.65338730
49Hypoplasia of dental enamel (HP:0006297)2.65014823
50Hemorrhage of the eye (HP:0011885)2.64257862
51Mesangial abnormality (HP:0001966)2.64129414
52Syncope (HP:0001279)2.64024746
53Abnormality of the 1st metacarpal (HP:0010009)2.63365821
54Metabolic alkalosis (HP:0200114)2.63010558
55Hyperglycinuria (HP:0003108)2.61779606
56Poikilocytosis (HP:0004447)2.61675408
57Abnormality of the vitamin B12 metabolism (HP:0004341)2.61138320
58Pancreatitis (HP:0001733)2.59809505
59Cerebral palsy (HP:0100021)2.59393388
60Intrahepatic cholestasis (HP:0001406)2.58747487
61Abnormal pancreas size (HP:0012094)2.58506847
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56765968
63Eczematoid dermatitis (HP:0000976)2.56554517
64Gastrointestinal dysmotility (HP:0002579)2.55558950
65Hyperactive renin-angiotensin system (HP:0000841)2.55171249
66Biliary tract neoplasm (HP:0100574)2.54633712
67Ureteral obstruction (HP:0006000)2.54572853
68Growth hormone excess (HP:0000845)2.53786342
69Hyperaldosteronism (HP:0000859)2.53333402
70Rectal prolapse (HP:0002035)2.46958458
71Vacuolated lymphocytes (HP:0001922)2.45944580
72Abnormality of the gastric mucosa (HP:0004295)2.44524603
73Ventricular tachycardia (HP:0004756)2.43620592
74Abnormality of vitamin B metabolism (HP:0004340)2.42389407
75Progressive hearing impairment (HP:0001730)2.41139133
76Increased IgE level (HP:0003212)2.40801009
77Cardiovascular calcification (HP:0011915)2.39722475
78Late onset (HP:0003584)2.37599629
79Abnormal hair laboratory examination (HP:0003328)2.36906605
80Gout (HP:0001997)2.35915206
81Abnormal biliary tract morphology (HP:0012440)2.35496088
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33521458
83Hoarse voice (HP:0001609)2.32790995
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.31626757
85Pigmentary retinal degeneration (HP:0001146)2.31343299
86Fragile skin (HP:0001030)2.31013532
87Alopecia of scalp (HP:0002293)2.30115251
88Nail dystrophy (HP:0008404)2.22055200
89Esophageal varix (HP:0002040)2.21684665
90Hypolipoproteinemia (HP:0010981)2.21212616
91Glomerulosclerosis (HP:0000096)2.19280118
92Abnormality of vitamin metabolism (HP:0100508)2.18214842
93Hypotension (HP:0002615)2.15856231
94Mucopolysacchariduria (HP:0008155)2.14698539
95Urinary glycosaminoglycan excretion (HP:0003541)2.14698539
96Nephrolithiasis (HP:0000787)2.12457702
97Abnormal foot bone ossification (HP:0010675)2.10797467
98Abnormality of macrophages (HP:0004311)2.10446684
99Abnormality of purine metabolism (HP:0004352)2.09766531
100Amyloidosis (HP:0011034)2.09728412
101Cervical subluxation (HP:0003308)2.09357970
102Abnormal blistering of the skin (HP:0008066)2.07102849
103Joint swelling (HP:0001386)2.06882902
104Reticulocytosis (HP:0001923)2.05445655
105Esophageal atresia (HP:0002032)2.05158020
106Glycosuria (HP:0003076)2.03411510
107Abnormality of urine glucose concentration (HP:0011016)2.03411510
108Amelogenesis imperfecta (HP:0000705)2.02024295
109Abnormal albumin level (HP:0012116)2.01313041
110Hypoalbuminemia (HP:0003073)2.01313041
111Increased mean platelet volume (HP:0011877)2.01235345
112Abnormality of the nasal mucosa (HP:0000433)2.00826243
113Focal segmental glomerulosclerosis (HP:0000097)2.00419906
114Hypoproteinemia (HP:0003075)1.99221619
115Abnormality of polysaccharide metabolism (HP:0011012)1.98565761
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98565761
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98565761
118Abnormality of pyrimidine metabolism (HP:0004353)1.97333671
119Abnormality of carpal bone ossification (HP:0006257)1.94625154
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.94615371
121Hyperphosphatemia (HP:0002905)1.92712651
122Ventricular fibrillation (HP:0001663)1.92132819
123Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91782178
124Symptomatic seizures (HP:0011145)1.91669026
125Abnormal glucose tolerance (HP:0001952)1.91560508
126Hyperparathyroidism (HP:0000843)1.91255958
127Hyperuricemia (HP:0002149)1.90080101
128Increased purine levels (HP:0004368)1.90080101
129Hyperammonemia (HP:0001987)1.89469006
130Ventricular arrhythmia (HP:0004308)1.89283231
131Cheilitis (HP:0100825)1.88603092
132Megaloblastic anemia (HP:0001889)1.88111386
133Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.87110472
134Short 1st metacarpal (HP:0010034)1.87110472
135Spontaneous abortion (HP:0005268)1.86742785
136Confusion (HP:0001289)1.86285475
137Xanthomatosis (HP:0000991)1.85627231
138Abnormality of the distal phalanges of the toes (HP:0010182)1.84195961
139Cone-rod dystrophy (HP:0000548)1.83673685
140Congenital sensorineural hearing impairment (HP:0008527)1.82774254
141Premature loss of primary teeth (HP:0006323)1.81675588
142Abnormality of chloride homeostasis (HP:0011422)1.80815715
143Uterine neoplasm (HP:0010784)1.80421179
144Dysostosis multiplex (HP:0000943)1.78732518
145Neoplasm of the small intestine (HP:0100833)1.78516814
146Facial diplegia (HP:0001349)1.76505079
147Flattened epiphyses (HP:0003071)1.75808561
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74286047
149* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.73708638
150Popliteal pterygium (HP:0009756)1.68590583
151Osteomyelitis (HP:0002754)1.67509510
152Gingival bleeding (HP:0000225)1.67194543
153Hypoglycemic coma (HP:0001325)1.66750382
154Abnormality of nucleobase metabolism (HP:0010932)1.66640368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.88701953
2MST45.87281379
3MST1R5.41118167
4EPHA24.09927386
5RIPK13.46142819
6NME13.24905081
7PIK3CA3.04434560
8LMTK23.02502723
9MAP2K22.98976048
10STK392.40445577
11EPHA32.39695515
12ACVR1B2.35157603
13PRKG22.25447429
14PTK62.15080818
15GRK62.13956639
16TESK12.07051224
17STK242.04073415
18MAP3K22.01795383
19MET2.00027524
20ERN11.73168087
21OXSR11.70324604
22EPHB21.68601040
23PRPF4B1.58828092
24STK101.56789668
25TAOK11.56209073
26FGFR31.49807231
27KSR21.46733849
28AKT31.45668534
29MAP3K101.40607602
30PTK21.39651589
31FER1.29967294
32PRKCI1.26295656
33RIPK41.23369665
34MAP2K11.23025617
35JAK11.22114846
36MYLK1.21398870
37CDC42BPA1.16460329
38EPHB11.14950275
39PAK41.09081845
40MAPKAPK31.06662340
41LIMK11.02066164
42ERBB41.01336891
43ZAP700.98915141
44MAP3K110.97575966
45MAP3K120.93756452
46BMX0.92418716
47DDR20.90461563
48TESK20.90193258
49MAP2K60.87087520
50MAP3K90.85527709
51IRAK10.83995265
52MAP3K80.83052707
53GRK10.81072483
54MAP3K10.80015192
55MAP3K70.77784218
56LRRK20.75873809
57CAMK2D0.75474339
58MATK0.71780212
59ERBB20.70062896
60CASK0.69369951
61PAK30.69348220
62MAP3K30.69048999
63MAP3K60.68105179
64NUAK10.65764002
65TGFBR20.65335613
66DMPK0.63578708
67LATS10.61705580
68TNIK0.59265923
69PKN20.56228243
70JAK30.54717894
71TBK10.53791386
72PRKAA20.53381550
73ICK0.49822056
74IKBKE0.47152479
75MAPK110.45119187
76SRC0.44922086
77MAPK70.44638547
78TYK20.44361201
79TAOK30.42000493
80TRIB30.41411268
81MAP4K10.41279103
82INSRR0.41012933
83HIPK20.40818386
84IGF1R0.40546571
85PDPK10.39566159
86BMPR20.38390959
87NLK0.37302545
88KIT0.37291985
89MELK0.36950764
90STK38L0.36652336
91PIM20.35931315
92IKBKB0.34717461
93CAMK2B0.34404449
94NEK60.33242236
95PRKCE0.33111421
96MAP3K140.32142490
97TTK0.31861946
98PAK10.31259042
99CAMK2G0.30699921
100TAOK20.30279350
101CSK0.29885385
102PDK20.29477967
103FGFR40.27802035
104PRKCA0.27543761
105PRKCZ0.27042601
106FGR0.26973512
107PDK10.26748562
108PRKAA10.26508109
109MAPKAPK20.25097929
110AURKB0.24842955
111DAPK20.24514840
112EEF2K0.23226722
113CDK60.23185807
114ROCK10.21908928
115ABL20.21738615
116SCYL20.20230980
117STK110.20103885
118FYN0.19812442
119PAK20.19637080
120PRKCD0.17291416
121STK30.17012906
122PDGFRA0.16770729
123ROCK20.16061100
124MAP3K130.15765126
125PRKACG0.14746923
126JAK20.12936930
127RET0.12439257
128CSNK1A10.12088600
129PDGFRB0.11159573
130RPS6KA10.11063458
131EGFR0.10980470
132DYRK1B0.10387649
133PRKCQ0.09815374
134PBK0.09718958

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.29478090
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.47052127
3Mineral absorption_Homo sapiens_hsa049783.99349872
4Renin-angiotensin system_Homo sapiens_hsa046143.75901979
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.56141643
6Vitamin digestion and absorption_Homo sapiens_hsa049773.28537119
7Bile secretion_Homo sapiens_hsa049762.74422287
8Sulfur metabolism_Homo sapiens_hsa009202.59143516
9Caffeine metabolism_Homo sapiens_hsa002322.40628297
10Protein digestion and absorption_Homo sapiens_hsa049742.31736776
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.97047829
12Galactose metabolism_Homo sapiens_hsa000521.89945774
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.79358325
14Fructose and mannose metabolism_Homo sapiens_hsa000511.74277929
15Histidine metabolism_Homo sapiens_hsa003401.71744444
16Staphylococcus aureus infection_Homo sapiens_hsa051501.63484944
17Asthma_Homo sapiens_hsa053101.58855472
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57355111
19Starch and sucrose metabolism_Homo sapiens_hsa005001.53574985
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.52580245
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52167918
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.46031069
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43902357
24Arginine biosynthesis_Homo sapiens_hsa002201.42518932
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38198469
26Glycerolipid metabolism_Homo sapiens_hsa005611.36204991
27Other glycan degradation_Homo sapiens_hsa005111.33202333
28* Thyroid hormone synthesis_Homo sapiens_hsa049181.32564855
29Autoimmune thyroid disease_Homo sapiens_hsa053201.31160927
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27604076
31Glutathione metabolism_Homo sapiens_hsa004801.27323966
32PPAR signaling pathway_Homo sapiens_hsa033201.22984670
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20587581
34Complement and coagulation cascades_Homo sapiens_hsa046101.20384433
35Linoleic acid metabolism_Homo sapiens_hsa005911.17690936
36Tight junction_Homo sapiens_hsa045301.14672523
37Allograft rejection_Homo sapiens_hsa053301.07403104
38Pancreatic secretion_Homo sapiens_hsa049721.07059869
39Type I diabetes mellitus_Homo sapiens_hsa049401.07014638
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05159702
41Folate biosynthesis_Homo sapiens_hsa007901.04800900
42Tryptophan metabolism_Homo sapiens_hsa003801.01424438
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95161062
44Salmonella infection_Homo sapiens_hsa051320.94541395
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93611191
46Graft-versus-host disease_Homo sapiens_hsa053320.90152137
47Gastric acid secretion_Homo sapiens_hsa049710.88219089
48Arginine and proline metabolism_Homo sapiens_hsa003300.86200943
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.85447689
50Sphingolipid metabolism_Homo sapiens_hsa006000.84216539
51Salivary secretion_Homo sapiens_hsa049700.77509652
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76666845
53African trypanosomiasis_Homo sapiens_hsa051430.76424767
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76341655
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.75055269
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72866277
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72511142
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.71623421
59Ether lipid metabolism_Homo sapiens_hsa005650.70968706
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68725608
61Arachidonic acid metabolism_Homo sapiens_hsa005900.68282522
62Fatty acid degradation_Homo sapiens_hsa000710.67791742
63Adherens junction_Homo sapiens_hsa045200.67518831
64Ovarian steroidogenesis_Homo sapiens_hsa049130.67286099
65Toxoplasmosis_Homo sapiens_hsa051450.65568085
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64091759
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63287046
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.63247107
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62589440
70Hepatitis C_Homo sapiens_hsa051600.60922102
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60181677
72Amoebiasis_Homo sapiens_hsa051460.56809738
73Pertussis_Homo sapiens_hsa051330.56263497
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55840925
75Antigen processing and presentation_Homo sapiens_hsa046120.55612390
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52472066
77Thyroid cancer_Homo sapiens_hsa052160.51297876
78ABC transporters_Homo sapiens_hsa020100.49739973
79GnRH signaling pathway_Homo sapiens_hsa049120.48292859
80Bladder cancer_Homo sapiens_hsa052190.48095723
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45836003
82Small cell lung cancer_Homo sapiens_hsa052220.44524673
83Lysosome_Homo sapiens_hsa041420.43505229
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43291822
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42823894
86Pentose phosphate pathway_Homo sapiens_hsa000300.41985901
87Peroxisome_Homo sapiens_hsa041460.41162121
88Rheumatoid arthritis_Homo sapiens_hsa053230.40764351
89Type II diabetes mellitus_Homo sapiens_hsa049300.39905923
90beta-Alanine metabolism_Homo sapiens_hsa004100.37062140
91Choline metabolism in cancer_Homo sapiens_hsa052310.36384218
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35273775
93Tyrosine metabolism_Homo sapiens_hsa003500.34963970
94Leishmaniasis_Homo sapiens_hsa051400.34483357
95Carbon metabolism_Homo sapiens_hsa012000.34318652
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33480363
97VEGF signaling pathway_Homo sapiens_hsa043700.33371317
98Fatty acid metabolism_Homo sapiens_hsa012120.33089642
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33080691
100N-Glycan biosynthesis_Homo sapiens_hsa005100.32956969
101Pyruvate metabolism_Homo sapiens_hsa006200.32394712
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.30912403
103ECM-receptor interaction_Homo sapiens_hsa045120.29513003
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29133118
105Tuberculosis_Homo sapiens_hsa051520.27304378
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26914438
107Nitrogen metabolism_Homo sapiens_hsa009100.26532953
108Viral myocarditis_Homo sapiens_hsa054160.25245519
109Shigellosis_Homo sapiens_hsa051310.23488774
110TNF signaling pathway_Homo sapiens_hsa046680.22059119
111Long-term depression_Homo sapiens_hsa047300.22041716
112Renin secretion_Homo sapiens_hsa049240.21784834
113Influenza A_Homo sapiens_hsa051640.21774356
114HIF-1 signaling pathway_Homo sapiens_hsa040660.21709384
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20654086
116Chemical carcinogenesis_Homo sapiens_hsa052040.19390418
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18880325
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.18867280
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.17888411
120Butanoate metabolism_Homo sapiens_hsa006500.17755998
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16613824
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16253085
123Steroid biosynthesis_Homo sapiens_hsa001000.16110360
124Insulin secretion_Homo sapiens_hsa049110.15760600
125Hematopoietic cell lineage_Homo sapiens_hsa046400.15470706
126Retinol metabolism_Homo sapiens_hsa008300.14564422
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.13023158
128Phenylalanine metabolism_Homo sapiens_hsa003600.12672065
129Metabolic pathways_Homo sapiens_hsa011000.11911724
130Vibrio cholerae infection_Homo sapiens_hsa051100.11662187

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