DUOXA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.27137065
2thyroid hormone metabolic process (GO:0042403)6.98688495
3adhesion of symbiont to host cell (GO:0044650)6.97201429
4virion attachment to host cell (GO:0019062)6.97201429
5vitamin A metabolic process (GO:0006776)6.49817175
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.38605026
7positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003606.22732582
8positive regulation of respiratory burst (GO:0060267)6.19153316
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.07299208
10adhesion of symbiont to host (GO:0044406)5.72374439
11maintenance of gastrointestinal epithelium (GO:0030277)5.69387370
12actin filament depolymerization (GO:0030042)5.63306905
13thyroid hormone generation (GO:0006590)5.62170941
14digestive system process (GO:0022600)5.56614171
15complement activation, classical pathway (GO:0006958)5.52889619
16hemidesmosome assembly (GO:0031581)5.22251739
17drug catabolic process (GO:0042737)5.16493410
18antibacterial humoral response (GO:0019731)5.08258733
19modified amino acid transport (GO:0072337)5.02088286
20antimicrobial humoral response (GO:0019730)4.97764282
21hydrogen peroxide catabolic process (GO:0042744)4.95713652
22glutathione biosynthetic process (GO:0006750)4.86673248
23bile acid and bile salt transport (GO:0015721)4.70173906
24regulation of bile acid biosynthetic process (GO:0070857)4.66296868
25complement activation (GO:0006956)4.63092563
26nonribosomal peptide biosynthetic process (GO:0019184)4.58468272
27regulation of metalloenzyme activity (GO:0048552)4.55447709
28regulation of cellular extravasation (GO:0002691)4.54832026
29flavonoid metabolic process (GO:0009812)4.54237007
30intestinal epithelial cell development (GO:0060576)4.53772556
31regulation of RIG-I signaling pathway (GO:0039535)4.53635933
32UDP-N-acetylglucosamine metabolic process (GO:0006047)4.52813284
33acute-phase response (GO:0006953)4.48297709
34long term synaptic depression (GO:0060292)4.36032871
35drinking behavior (GO:0042756)4.35026680
36epithelial structure maintenance (GO:0010669)4.30941464
373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.29051957
38purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.29051957
39diacylglycerol metabolic process (GO:0046339)4.28809392
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.16386848
41tetrapyrrole metabolic process (GO:0033013)4.05652829
42phospholipid efflux (GO:0033700)4.05370032
43regulation of cholesterol esterification (GO:0010872)4.02445808
44regulation of respiratory burst (GO:0060263)3.99033513
45glucose 6-phosphate metabolic process (GO:0051156)3.98097694
46O-glycan processing (GO:0016266)3.96805204
47hepatocyte apoptotic process (GO:0097284)3.94809782
48positive regulation of triglyceride lipase activity (GO:0061365)3.90977387
49positive regulation of lipoprotein lipase activity (GO:0051006)3.90977387
50regulation of viral release from host cell (GO:1902186)3.89825295
51sulfation (GO:0051923)3.89010659
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.88977143
53glomerular filtration (GO:0003094)3.88314229
54plasma lipoprotein particle assembly (GO:0034377)3.87063496
55protein-lipid complex assembly (GO:0065005)3.82634904
56response to hepatocyte growth factor (GO:0035728)3.81632964
57cellular response to hepatocyte growth factor stimulus (GO:0035729)3.81632964
58sulfate transmembrane transport (GO:1902358)3.81462441
59regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.80062397
60lipoprotein metabolic process (GO:0042157)3.78094884
61sulfur compound transport (GO:0072348)3.76926564
62acute inflammatory response (GO:0002526)3.76384166
63digestion (GO:0007586)3.73868300
64regulation of interleukin-8 secretion (GO:2000482)3.73649444
65purine nucleotide salvage (GO:0032261)3.71735416
66regulation of triglyceride catabolic process (GO:0010896)3.71709907
67defense response to fungus (GO:0050832)3.69016597
68cGMP-mediated signaling (GO:0019934)3.67670087
69leukotriene biosynthetic process (GO:0019370)3.67409798
70protein activation cascade (GO:0072376)3.67332151
71renal filtration (GO:0097205)3.62012072
72* hydrogen peroxide metabolic process (GO:0042743)3.61680192
73peptide biosynthetic process (GO:0043043)3.57452209
74positive regulation of Rho protein signal transduction (GO:0035025)3.55524871
75regulation of complement activation (GO:0030449)3.53771901
76transcytosis (GO:0045056)3.53687312
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53516033
78complement activation, alternative pathway (GO:0006957)3.53313515
79glutathione derivative metabolic process (GO:1901685)3.53186843
80glutathione derivative biosynthetic process (GO:1901687)3.53186843
81positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)3.52726374
82regulation of protein activation cascade (GO:2000257)3.48914620
83positive regulation of pseudopodium assembly (GO:0031274)3.44907295
84peptide hormone processing (GO:0016486)3.44292667
85disruption of cells of other organism (GO:0044364)3.42500324
86killing of cells of other organism (GO:0031640)3.42500324
87negative regulation of sterol transport (GO:0032372)3.41463203
88negative regulation of cholesterol transport (GO:0032375)3.41463203
89phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.41074989
90response to laminar fluid shear stress (GO:0034616)3.40300459
91negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.40021252
92arginine catabolic process (GO:0006527)3.38645006
93cholesterol efflux (GO:0033344)3.38015386
94regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.37290935
95positive regulation of T cell differentiation in thymus (GO:0033089)3.33952064
96regulation of acrosome reaction (GO:0060046)3.32843482
97glycerophospholipid catabolic process (GO:0046475)3.32153210
98pyrimidine-containing compound transmembrane transport (GO:0072531)3.30359532
99water-soluble vitamin metabolic process (GO:0006767)3.25207155
100phosphatidylserine acyl-chain remodeling (GO:0036150)3.23092654
101regulation of cholesterol homeostasis (GO:2000188)3.21898185
102chronic inflammatory response (GO:0002544)3.18963639
103innate immune response in mucosa (GO:0002227)3.18750523
104cholesterol homeostasis (GO:0042632)3.17308029
105sterol homeostasis (GO:0055092)3.17196247
106cellular response to fluid shear stress (GO:0071498)3.16444919
107sterol transport (GO:0015918)3.15826747
108cholesterol transport (GO:0030301)3.15826747
109hypotonic response (GO:0006971)3.15104219
110oligosaccharide biosynthetic process (GO:0009312)3.14356434
111thyroid gland development (GO:0030878)3.13671309
112parturition (GO:0007567)3.12325342
113very-low-density lipoprotein particle assembly (GO:0034379)3.09865301
114regulation of pseudopodium assembly (GO:0031272)3.08336101
115sulfate transport (GO:0008272)3.07810141
116protein neddylation (GO:0045116)3.07535677
117positive regulation of fatty acid biosynthetic process (GO:0045723)3.07068341
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.06277771
119ventricular cardiac muscle cell action potential (GO:0086005)3.05413184
120phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.05080434
121response to hydroperoxide (GO:0033194)3.04969624
122negative regulation of hormone biosynthetic process (GO:0032353)3.01453196
123negative regulation of hormone metabolic process (GO:0032351)3.01453196
124negative regulation of transcription by competitive promoter binding (GO:0010944)3.00713797
125cysteine metabolic process (GO:0006534)3.00270116
126transepithelial transport (GO:0070633)2.99591179
127glucuronate metabolic process (GO:0019585)2.99242209
128uronic acid metabolic process (GO:0006063)2.99242209
129negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.97989409
130peptide catabolic process (GO:0043171)2.95583614
131neutral amino acid transport (GO:0015804)2.95522654
132L-fucose catabolic process (GO:0042355)2.93514907
133fucose catabolic process (GO:0019317)2.93514907
134L-fucose metabolic process (GO:0042354)2.93514907
135peroxisome fission (GO:0016559)2.93400165
136adenosine metabolic process (GO:0046085)2.93319016
137regulation of heterotypic cell-cell adhesion (GO:0034114)2.92363886
138positive regulation of glycoprotein biosynthetic process (GO:0010560)2.89188520
139regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.88601654
140negative regulation of endothelial cell apoptotic process (GO:2000352)2.88506893
141regulation of transforming growth factor beta1 production (GO:0032908)2.87152840
142regulation of systemic arterial blood pressure by hormone (GO:0001990)2.87133728
143regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.87133728
144endocrine process (GO:0050886)2.87133728
145protein autoprocessing (GO:0016540)2.86610517
146reverse cholesterol transport (GO:0043691)2.83296458
147leukotriene metabolic process (GO:0006691)2.82530672
148desmosome organization (GO:0002934)2.82258017
149regulation of guanylate cyclase activity (GO:0031282)2.82192008
150lipoprotein transport (GO:0042953)2.82187927
151regulation of proton transport (GO:0010155)2.80957644
152positive regulation of glycoprotein metabolic process (GO:1903020)2.80609226
153negative regulation of protein activation cascade (GO:2000258)2.80089023
154extracellular matrix disassembly (GO:0022617)2.80059974
155regulation of actin nucleation (GO:0051125)2.79516753
156negative regulation of thymocyte apoptotic process (GO:0070244)2.79270753
157mucosal immune response (GO:0002385)2.79008356
158fucosylation (GO:0036065)2.78633656
159glutathione metabolic process (GO:0006749)2.76184269
160phosphatidylinositol acyl-chain remodeling (GO:0036149)2.75421198
161hormone catabolic process (GO:0042447)2.73684572
162vitamin metabolic process (GO:0006766)2.73375582
163retinol metabolic process (GO:0042572)2.68860403
164regulation of apoptotic process involved in morphogenesis (GO:1902337)2.68078134
165regulation of apoptotic cell clearance (GO:2000425)2.65033532
166arginine metabolic process (GO:0006525)2.62641497
167positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.60835052
168positive regulation of glomerulus development (GO:0090193)2.59991150
169regulation of mononuclear cell migration (GO:0071675)2.58048375
170phosphatidylserine metabolic process (GO:0006658)2.57556277
171humoral immune response (GO:0006959)2.57144441
172regulation of calcium ion import (GO:0090279)2.54345410
173regulation of cytokine secretion involved in immune response (GO:0002739)2.53577729
174negative regulation of epidermal cell differentiation (GO:0045605)2.52249544
175positive regulation of extracellular matrix organization (GO:1903055)2.50838152
176endocrine pancreas development (GO:0031018)2.49673964
177cobalamin metabolic process (GO:0009235)11.9697715
178intestinal absorption (GO:0050892)11.1648949
179intestinal cholesterol absorption (GO:0030299)10.3755204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.40856465
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.95149719
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.36923850
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.34805349
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.14989858
6GATA4_25053715_ChIP-Seq_YYC3_Human3.05965256
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.00130474
8SOX2_20726797_ChIP-Seq_SW620_Human2.74961592
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.69730931
10GATA6_25053715_ChIP-Seq_YYC3_Human2.62853056
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39087608
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.35335862
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.22451950
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18349095
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.08848254
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05654732
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02321856
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.02091397
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.96957169
20KLF5_25053715_ChIP-Seq_YYC3_Human1.96667062
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91520376
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.90363762
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85285464
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.84423125
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83057340
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.81003623
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.72661247
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72258002
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70062152
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68884489
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66145831
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.65572797
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.65372190
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65240476
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61162256
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60412542
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57644947
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56323293
39ATF3_27146783_Chip-Seq_COLON_Human1.54954954
40RACK7_27058665_Chip-Seq_MCF-7_Human1.50495452
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46617130
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44444161
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43330991
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39280724
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39091493
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.37280029
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35686368
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35636529
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.30012360
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29060037
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.27364582
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27233827
53GATA2_19941826_ChIP-Seq_K562_Human1.26207181
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25436377
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24682970
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22921790
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22921790
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.20712321
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19848275
60CLOCK_20551151_ChIP-Seq_293T_Human1.19535659
61AR_21909140_ChIP-Seq_LNCAP_Human1.18399549
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15593199
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15496353
64ZNF263_19887448_ChIP-Seq_K562_Human1.14818767
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14013237
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13489666
67HNF4A_19822575_ChIP-Seq_HepG2_Human1.09903462
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08626516
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07949805
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07835228
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06693248
72* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04514400
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04490661
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04356123
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03724883
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02514708
77EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98860423
78FOXA2_19822575_ChIP-Seq_HepG2_Human0.98747593
79GATA2_21666600_ChIP-Seq_HMVEC_Human0.97040009
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95178297
81EGR1_19032775_ChIP-ChIP_M12_Human0.95056466
82BCOR_27268052_Chip-Seq_Bcells_Human0.94661855
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94373579
84GATA3_24758297_ChIP-Seq_MCF-7_Human0.94014202
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93966983
86* CREB1_26743006_Chip-Seq_LNCaP_Human0.93130980
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91478017
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89912897
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89766473
90GATA1_26923725_Chip-Seq_HPCs_Mouse0.89129905
91CJUN_26792858_Chip-Seq_BT549_Human0.88683314
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88671705
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87406596
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87106370
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86762707
96TAF2_19829295_ChIP-Seq_ESCs_Human0.86703698
97ERA_21632823_ChIP-Seq_H3396_Human0.86506278
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86029807
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85649838
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85038844
101P300_27268052_Chip-Seq_Bcells_Human0.84129565
102LXR_22292898_ChIP-Seq_THP-1_Human0.83999768
103E2F1_20622854_ChIP-Seq_HELA_Human0.83868568
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.83836779
105AHR_22903824_ChIP-Seq_MCF-7_Human0.83766041
106SA1_27219007_Chip-Seq_Bcells_Human0.83686775
107GATA1_19941826_ChIP-Seq_K562_Human0.83304598
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83086954
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.82378844
110NANOG_20526341_ChIP-Seq_ESCs_Human0.82183713
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81740983
112CDX2_22108803_ChIP-Seq_LS180_Human0.81053350
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81024514
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81000754
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79789626
116* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79367221
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78879576
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78847250
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78608996
120TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78374529
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.77827654
122ELF5_23300383_ChIP-Seq_T47D_Human0.77406667
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76274396
124TP63_23658742_ChIP-Seq_EP156T_Human0.76048337
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74855161
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74797690
127STAT1_17558387_ChIP-Seq_HELA_Human0.74747596
128BCAT_22108803_ChIP-Seq_LS180_Human0.74499207
129IRF8_27001747_Chip-Seq_BMDM_Mouse0.73465313
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72598343
131CEBPB_22108803_ChIP-Seq_LS180_Human0.72542483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.40858398
2MP0010234_abnormal_vibrissa_follicle5.33048166
3MP0001666_abnormal_nutrient_absorption5.18460990
4MP0005083_abnormal_biliary_tract4.46362937
5MP0004264_abnormal_extraembryonic_tissu4.40406543
6MP0002138_abnormal_hepatobiliary_system3.88651473
7MP0003183_abnormal_peptide_metabolism3.64672768
8MP0000462_abnormal_digestive_system3.35852799
9MP0002876_abnormal_thyroid_physiology3.33065941
10MP0009840_abnormal_foam_cell3.29067978
11MP0005085_abnormal_gallbladder_physiolo2.97980943
12MP0000537_abnormal_urethra_morphology2.85310137
13MP0010386_abnormal_urinary_bladder2.68690622
14MP0003866_abnormal_defecation2.58845347
15MP0003252_abnormal_bile_duct2.58116139
16MP0002139_abnormal_hepatobiliary_system2.54643492
17MP0000538_abnormal_urinary_bladder2.24723789
18MP0003724_increased_susceptibility_to2.20185161
19MP0010329_abnormal_lipoprotein_level2.00795926
20MP0003011_delayed_dark_adaptation1.94608738
21MP0001664_abnormal_digestion1.93237893
22MP0010155_abnormal_intestine_physiology1.93170524
23MP0005381_digestive/alimentary_phenotyp1.92367352
24MP0001663_abnormal_digestive_system1.87573764
25MP0001756_abnormal_urination1.84822836
26MP0004147_increased_porphyrin_level1.80675137
27MP0001873_stomach_inflammation1.74566203
28MP0005084_abnormal_gallbladder_morpholo1.71592616
29MP0001849_ear_inflammation1.70397166
30MP0003436_decreased_susceptibility_to1.69698028
31MP0010352_gastrointestinal_tract_polyps1.68749376
32MP0005365_abnormal_bile_salt1.67654643
33MP0003705_abnormal_hypodermis_morpholog1.67210334
34MP0000477_abnormal_intestine_morphology1.62016430
35MP0000465_gastrointestinal_hemorrhage1.61379164
36MP0008875_abnormal_xenobiotic_pharmacok1.54921165
37MP0006054_spinal_hemorrhage1.50911658
38MP0010678_abnormal_skin_adnexa1.50443850
39MP0004019_abnormal_vitamin_homeostasis1.48742271
40MP0003075_altered_response_to1.44253970
41MP0002132_abnormal_respiratory_system1.41729900
42MP0008004_abnormal_stomach_pH1.41556597
43MP0000490_abnormal_crypts_of1.39348306
44MP0002796_impaired_skin_barrier1.35967379
45MP0001533_abnormal_skeleton_physiology1.33096036
46MP0000685_abnormal_immune_system1.31737652
47MP0005451_abnormal_body_composition1.30550872
48MP0002277_abnormal_respiratory_mucosa1.28344268
49MP0005377_hearing/vestibular/ear_phenot1.26901646
50MP0003878_abnormal_ear_physiology1.26901646
51MP0002166_altered_tumor_susceptibility1.23579852
52MP0003806_abnormal_nucleotide_metabolis1.23084937
53MP0001790_abnormal_immune_system1.21141012
54MP0005387_immune_system_phenotype1.21141012
55MP0009379_abnormal_foot_pigmentation1.19322059
56MP0000681_abnormal_thyroid_gland1.13807055
57MP0003453_abnormal_keratinocyte_physiol1.13410248
58MP0002909_abnormal_adrenal_gland1.12065813
59MP0003195_calcinosis1.11854991
60MP0009643_abnormal_urine_homeostasis1.09242881
61MP0005025_abnormal_response_to1.09229909
62MP0003300_gastrointestinal_ulcer1.07682824
63MP0003186_abnormal_redox_activity1.05450135
64MP0003938_abnormal_ear_development1.04344753
65MP0004947_skin_inflammation1.03864505
66MP0005220_abnormal_exocrine_pancreas1.03400196
67MP0005448_abnormal_energy_balance1.02384105
68MP0004043_abnormal_pH_regulation1.01755753
69MP0003191_abnormal_cellular_cholesterol1.01258274
70MP0002822_catalepsy1.00912388
71MP0005501_abnormal_skin_physiology0.99173540
72MP0002163_abnormal_gland_morphology0.97475280
73MP0008469_abnormal_protein_level0.96600070
74MP0000516_abnormal_urinary_system0.96250008
75MP0005367_renal/urinary_system_phenotyp0.96250008
76MP0005332_abnormal_amino_acid0.95213418
77MP0009697_abnormal_copulation0.95028677
78MP0003315_abnormal_perineum_morphology0.94988481
79MP0001845_abnormal_inflammatory_respons0.93694196
80MP0003283_abnormal_digestive_organ0.93629153
81MP0002006_tumorigenesis0.93188997
82MP0005166_decreased_susceptibility_to0.92875892
83MP0001764_abnormal_homeostasis0.90972379
84MP0003718_maternal_effect0.90471090
85MP0002254_reproductive_system_inflammat0.89690840
86MP0001216_abnormal_epidermal_layer0.89634762
87MP0005310_abnormal_salivary_gland0.85894372
88MP0001661_extended_life_span0.85676988
89MP0002148_abnormal_hypersensitivity_rea0.83991605
90MP0005167_abnormal_blood-brain_barrier0.83770542
91MP0000470_abnormal_stomach_morphology0.82779419
92MP0000609_abnormal_liver_physiology0.82714809
93MP0009333_abnormal_splenocyte_physiolog0.82560276
94MP0000467_abnormal_esophagus_morphology0.82082396
95MP0003329_amyloid_beta_deposits0.81880607
96MP0000604_amyloidosis0.80552001
97MP0005248_abnormal_Harderian_gland0.80333949
98MP0001765_abnormal_ion_homeostasis0.79556875
99MP0000613_abnormal_salivary_gland0.79095140
100MP0002098_abnormal_vibrissa_morphology0.78182249
101MP0002089_abnormal_postnatal_growth/wei0.77143595
102MP0002118_abnormal_lipid_homeostasis0.76229578
103MP0010307_abnormal_tumor_latency0.74107160
104MP0000343_altered_response_to0.73902788
105MP0004270_analgesia0.73458235
106MP0001501_abnormal_sleep_pattern0.73273992
107MP0000249_abnormal_blood_vessel0.70185178
108MP0002060_abnormal_skin_morphology0.67737904
109MP0003045_fibrosis0.67653571
110MP0005058_abnormal_lysosome_morphology0.67488130
111MP0005464_abnormal_platelet_physiology0.67478940
112MP0002136_abnormal_kidney_physiology0.67414759
113MP0008775_abnormal_heart_ventricle0.67045278
114MP0004782_abnormal_surfactant_physiolog0.64805603
115MP0009780_abnormal_chondrocyte_physiolo0.64503606
116MP0005164_abnormal_response_to0.64242212
117MP0005187_abnormal_penis_morphology0.63187987
118MP0003448_altered_tumor_morphology0.63183821
119MP0001800_abnormal_humoral_immune0.63129258
120MP0005670_abnormal_white_adipose0.62489569
121MP0003953_abnormal_hormone_level0.62457619
122MP0005023_abnormal_wound_healing0.60269887
123MP0000383_abnormal_hair_follicle0.59898515
124MP0008872_abnormal_physiological_respon0.59476853
125MP0005636_abnormal_mineral_homeostasis0.59199136
126MP0003950_abnormal_plasma_membrane0.58832235
127MP0004858_abnormal_nervous_system0.58006940
128MP0000579_abnormal_nail_morphology0.56864342
129MP0001881_abnormal_mammary_gland0.56232203
130MP0010771_integument_phenotype0.55213405
131MP0003879_abnormal_hair_cell0.54967603
132MP0005319_abnormal_enzyme/_coenzyme0.54805036
133MP0003868_abnormal_feces_composition0.53619666
134MP0009053_abnormal_anal_canal0.53310388
135MP0005266_abnormal_metabolism0.52632421
136MP0009384_cardiac_valve_regurgitation0.51946812
137MP0009785_altered_susceptibility_to0.48078811
138MP0009642_abnormal_blood_homeostasis0.47531159
139MP0000377_abnormal_hair_follicle0.45546225
140MP0006138_congestive_heart_failure0.44645446
141MP0003693_abnormal_embryo_hatching0.44253071
142MP0005165_increased_susceptibility_to0.44037757

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.98238943
2Exocrine pancreatic insufficiency (HP:0001738)7.72561010
3Abnormality of glutamine family amino acid metabolism (HP:0010902)7.59482697
4Right ventricular cardiomyopathy (HP:0011663)6.98797810
5Ileus (HP:0002595)6.90690333
6Hydroxyprolinuria (HP:0003080)5.95092775
7Abnormality of proline metabolism (HP:0010907)5.95092775
8Hypoproteinemia (HP:0003075)5.61663527
9Gout (HP:0001997)5.53141758
10Autoimmune thrombocytopenia (HP:0001973)5.32361546
11Onycholysis (HP:0001806)5.24073454
12Malnutrition (HP:0004395)4.72520615
13Milia (HP:0001056)4.68665216
14Cupped ribs (HP:0000887)4.42976809
15Glomerulonephritis (HP:0000099)4.36561205
16Fragile nails (HP:0001808)4.33107244
17Pustule (HP:0200039)4.27351160
18Acanthocytosis (HP:0001927)4.25011680
19Atrophic scars (HP:0001075)4.21472035
20Hyperuricemia (HP:0002149)4.06823610
21Increased purine levels (HP:0004368)4.06823610
22Hypobetalipoproteinemia (HP:0003563)3.97774152
23Chronic diarrhea (HP:0002028)3.92933756
24Autoimmune hemolytic anemia (HP:0001890)3.85099787
25Conjugated hyperbilirubinemia (HP:0002908)3.79025340
26Systemic lupus erythematosus (HP:0002725)3.72239472
27Tubulointerstitial nephritis (HP:0001970)3.70811936
28Complement deficiency (HP:0004431)3.60236617
29Pancreatitis (HP:0001733)3.55563674
30Abdominal distention (HP:0003270)3.54820072
31* Goiter (HP:0000853)3.53084103
32Mesangial abnormality (HP:0001966)3.47826814
33Abnormality of the 1st metacarpal (HP:0010009)3.29838575
34Hyperglycinuria (HP:0003108)3.23527587
35Increased IgE level (HP:0003212)3.22979506
36Plantar hyperkeratosis (HP:0007556)3.13746624
37Abnormality of complement system (HP:0005339)3.13365895
38Fat malabsorption (HP:0002630)3.08951895
39Pili torti (HP:0003777)3.02785209
40Woolly hair (HP:0002224)2.95279904
41Renal salt wasting (HP:0000127)2.94744598
42Palpitations (HP:0001962)2.91529698
43Poikilocytosis (HP:0004447)2.86028150
44Dehydration (HP:0001944)2.83178425
45Stridor (HP:0010307)2.82490777
46Micronodular cirrhosis (HP:0001413)2.82265506
47Villous atrophy (HP:0011473)2.78102660
48Abnormality of small intestinal villus morphology (HP:0011472)2.78102660
49Nephritis (HP:0000123)2.73412185
50Myopathic facies (HP:0002058)2.73152109
51Abnormal tarsal ossification (HP:0008369)2.72359099
52Abnormality of the distal phalanges of the toes (HP:0010182)2.70422531
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.69972579
54Pigmentary retinal degeneration (HP:0001146)2.65997986
55B lymphocytopenia (HP:0010976)2.65187469
56Abnormality of B cell number (HP:0010975)2.65187469
57Hypoglycemic coma (HP:0001325)2.65090201
58Hypolipoproteinemia (HP:0010981)2.64647962
59Hand muscle atrophy (HP:0009130)2.63316089
60Mildly elevated creatine phosphokinase (HP:0008180)2.62540418
61Gastrointestinal dysmotility (HP:0002579)2.62296089
62Spinal muscular atrophy (HP:0007269)2.59524358
63Abnormality of the gastric mucosa (HP:0004295)2.58801695
64Barrel-shaped chest (HP:0001552)2.58308034
65Flat acetabular roof (HP:0003180)2.57912870
66Syncope (HP:0001279)2.57430765
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.56826569
68Ureteral stenosis (HP:0000071)2.55542247
69Diaphragmatic weakness (HP:0009113)2.54865519
70Distal lower limb muscle weakness (HP:0009053)2.52701437
71Cheilitis (HP:0100825)2.52636925
72Abnormal glucose tolerance (HP:0001952)2.50527987
73Increased serum pyruvate (HP:0003542)2.49010662
74Tubulointerstitial fibrosis (HP:0005576)2.48335817
75Abnormality of nucleobase metabolism (HP:0010932)2.47250078
76Abnormal pancreas size (HP:0012094)2.46603592
77Late onset (HP:0003584)2.45794923
78Abnormality of the vitamin B12 metabolism (HP:0004341)2.44678992
79Disproportionate short-trunk short stature (HP:0003521)2.44551816
80Abnormality of chloride homeostasis (HP:0011422)2.44319189
81Abnormality of the pleura (HP:0002103)2.42078733
82Glomerulosclerosis (HP:0000096)2.40684530
83Ureteral obstruction (HP:0006000)2.39636420
84Glucose intolerance (HP:0000833)2.39092779
85Abnormality of monocarboxylic acid metabolism (HP:0010996)2.38388583
86Biliary tract neoplasm (HP:0100574)2.37846909
87Rough bone trabeculation (HP:0100670)2.37737065
88Abnormality of urine glucose concentration (HP:0011016)2.37275450
89Glycosuria (HP:0003076)2.37275450
90Vascular calcification (HP:0004934)2.37110870
91Curly hair (HP:0002212)2.33498002
92Abnormal biliary tract morphology (HP:0012440)2.31275399
93Upper limb amyotrophy (HP:0009129)2.31271329
94Distal upper limb amyotrophy (HP:0007149)2.31271329
95Hypoplasia of dental enamel (HP:0006297)2.31021474
96Amyloidosis (HP:0011034)2.28898670
97Reticulocytosis (HP:0001923)2.28572264
98Intrahepatic cholestasis (HP:0001406)2.28551759
99Abnormality of purine metabolism (HP:0004352)2.26608243
100Progressive sensorineural hearing impairment (HP:0000408)2.25600406
101Abnormality of vitamin B metabolism (HP:0004340)2.25566030
102Ventricular tachycardia (HP:0004756)2.25205598
103Fragile skin (HP:0001030)2.24579631
104Cervical subluxation (HP:0003308)2.24403604
105Hyperactive renin-angiotensin system (HP:0000841)2.24349958
106Nephrolithiasis (HP:0000787)2.23637065
107Spontaneous abortion (HP:0005268)2.23136955
108Abnormality of glycolysis (HP:0004366)2.20636343
109Congenital, generalized hypertrichosis (HP:0004540)2.20135532
110Abnormal hair laboratory examination (HP:0003328)2.20067222
111Increased mean platelet volume (HP:0011877)2.19925181
112Severe combined immunodeficiency (HP:0004430)2.19750337
113Large for gestational age (HP:0001520)2.15477405
114Abnormality of the distal phalanx of the thumb (HP:0009617)2.15295059
115Alopecia of scalp (HP:0002293)2.13089273
116Cardiovascular calcification (HP:0011915)2.12885844
117Short phalanx of the thumb (HP:0009660)2.12574511
118Abnormality of carpal bone ossification (HP:0006257)2.11561399
119Combined immunodeficiency (HP:0005387)2.10707714
120Tubular atrophy (HP:0000092)2.10576679
121Short 1st metacarpal (HP:0010034)2.10409384
122Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.10409384
123Hypotension (HP:0002615)2.10359432
124Polycythemia (HP:0001901)2.09671311
125Hyperphosphatemia (HP:0002905)2.09414090
126Abnormal blistering of the skin (HP:0008066)2.09260855
127Congenital sensorineural hearing impairment (HP:0008527)2.08711652
128Abnormality of the middle phalanges of the toes (HP:0010183)2.07874399
129Patent foramen ovale (HP:0001655)2.06990773
130Vacuolated lymphocytes (HP:0001922)2.06482054
131Abnormality of glycine metabolism (HP:0010895)2.05078600
132Abnormality of serine family amino acid metabolism (HP:0010894)2.05078600
133Esophageal varix (HP:0002040)2.04340342
134Hypoplasia of the odontoid process (HP:0003311)2.02021329
135Sensorimotor neuropathy (HP:0007141)2.01378268
136Xanthomatosis (HP:0000991)2.00913109
137Muscle fiber splitting (HP:0003555)2.00623499
138Abnormality of vitamin metabolism (HP:0100508)2.00375552
139Abnormality of the renal cortex (HP:0011035)1.99323993
140Hypoglycemic seizures (HP:0002173)1.98049840
141Nail dystrophy (HP:0008404)1.97615890
142Decreased circulating renin level (HP:0003351)1.97588532
143Hyperparathyroidism (HP:0000843)1.97392230
144Aplasia of the musculature (HP:0100854)1.97054369
145Alkalosis (HP:0001948)1.96483229
146Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96339984
147Abnormality of the 2nd finger (HP:0004100)1.95776063
148Focal segmental glomerulosclerosis (HP:0000097)1.95177835
149Urinary glycosaminoglycan excretion (HP:0003541)1.95008388
150Mucopolysacchariduria (HP:0008155)1.95008388
151Widely patent fontanelles and sutures (HP:0004492)1.91998266
152Confusion (HP:0001289)1.91607893
153Abnormal trabecular bone morphology (HP:0100671)1.90480645
154Ventricular fibrillation (HP:0001663)1.90214821
155Hepatic necrosis (HP:0002605)1.89384486
156Abnormality of the vocal cords (HP:0008777)1.88390495
157Rectal prolapse (HP:0002035)1.88109153
158Abnormal vertebral ossification (HP:0100569)1.87945449
159Fetal akinesia sequence (HP:0001989)1.85780711
160Cone-rod dystrophy (HP:0000548)1.85620928
161Thyroiditis (HP:0100646)1.84786829
162Obstructive sleep apnea (HP:0002870)1.82846564
163Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82645550
164Abnormality of polysaccharide metabolism (HP:0011012)1.82645550
165Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82645550
166Sparse eyelashes (HP:0000653)1.81548216
167Rhabdomyolysis (HP:0003201)1.76514104
168Abnormality of renin-angiotensin system (HP:0000847)1.73049742
169Abnormality of macrophages (HP:0004311)1.70421281
170Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70100567
171Epiphyseal dysplasia (HP:0002656)1.70024570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.83410870
2FRK5.66003385
3MST1R5.39094884
4EPHA24.78588359
5STK393.39009094
6NME13.16691188
7LMTK22.94300277
8MAP2K22.87581649
9RIPK12.55210597
10OXSR12.49877244
11GRK62.29212555
12PRKG22.27368221
13ZAP702.22897234
14PTK62.12154978
15TESK12.07340208
16KSR21.96317418
17MAP3K21.93869564
18MET1.93500406
19EPHB21.77043712
20VRK21.74876440
21ERN11.74339651
22ERBB41.66715239
23TAOK11.57403968
24PIK3CA1.56547458
25TNIK1.50042935
26INSRR1.45983131
27AKT31.41824212
28TESK21.40444929
29STK101.39761184
30MAP2K11.36308069
31MAP3K101.31821407
32FER1.31131758
33MAP3K121.24001364
34NLK1.23815899
35PRKCI1.23204199
36PTK21.22327141
37PAK41.21520597
38EPHB11.18552308
39GRK11.18104943
40TGFBR21.16170773
41ACVR1B1.14831204
42MAP3K91.10098043
43LATS11.08641785
44MYLK1.08107937
45RIPK41.05763309
46MAP3K11.04072197
47LIMK11.03313739
48MAP2K60.94681980
49MAP3K110.91696277
50BMX0.89279255
51DMPK0.86757150
52TTK0.86614667
53MAP3K80.86518709
54MAPK70.84522919
55DDR20.84454254
56NUAK10.84415871
57IKBKB0.79887071
58DAPK10.79167708
59ERBB20.78448712
60IKBKE0.76033512
61PAK30.70376252
62LRRK20.67015972
63MAP3K140.66549855
64JAK10.65765489
65CDC42BPA0.65717341
66PRKAA20.65477663
67FGFR30.63494100
68PDGFRB0.61684665
69MATK0.61403050
70TAOK30.60438387
71MAP3K70.59871303
72EEF2K0.57915150
73TNK20.56284818
74PRKCQ0.54904049
75MAPK110.54573510
76CAMK2D0.54306361
77IRAK10.53377281
78PIM20.52882501
79CLK10.52822512
80MAP3K30.51577988
81KSR10.49890004
82TBK10.49039388
83LATS20.48208798
84PDPK10.47631142
85TYK20.47626790
86IGF1R0.46511402
87PAK10.44167905
88PBK0.42505957
89ILK0.42169839
90TRIB30.41088798
91STK30.40442108
92PKN20.39799834
93TIE10.39708155
94AURKB0.38908199
95DAPK20.38859186
96PRKCE0.38756293
97PHKG20.38642366
98PHKG10.38642366
99EPHA30.38046900
100MAPKAPK30.36306073
101CAMK2G0.35963098
102ADRBK20.35821600
103SRC0.35786114
104MAP3K60.33492713
105STK160.33279902
106PIK3CG0.32191740
107CAMK2B0.31222137
108ARAF0.31179834
109PRKAA10.30618508
110CDK60.29927419
111RAF10.29339209
112MAP3K130.29236247
113JAK30.29163702
114PRKCA0.28978597
115FES0.27891096
116MELK0.27498410
117MAPKAPK20.27449952
118PDK10.27248902
119BMPR1B0.26652473
120TYRO30.26623332
121DAPK30.26022656
122PRKACG0.23730523
123STK38L0.23472992
124BMPR20.23219622
125ICK0.23103703
126PDK20.22976409
127EGFR0.20935466
128JAK20.19833679
129ROCK10.19650626
130PRPF4B0.19540032
131CHUK0.19128877
132CSK0.18549776
133RPS6KB20.18474168
134STK240.18126441
135CSNK1A10.18006388
136FGR0.17756600
137IRAK40.17685678
138PRKCD0.17485667
139MAP3K50.16445453
140SGK10.16043435
141SCYL20.15706961
142HIPK20.15343480
143RET0.13697571
144FYN0.13170012
145FGFR40.11984572
146ABL20.11359588

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.78481341
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.74953926
3Mineral absorption_Homo sapiens_hsa049784.26215303
4Renin-angiotensin system_Homo sapiens_hsa046143.92412791
5Vitamin digestion and absorption_Homo sapiens_hsa049773.77700612
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.99134625
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.88009722
8Sulfur metabolism_Homo sapiens_hsa009202.55825117
9Bile secretion_Homo sapiens_hsa049762.42023066
10Protein digestion and absorption_Homo sapiens_hsa049742.33878221
11Caffeine metabolism_Homo sapiens_hsa002322.31273708
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.10279013
13Complement and coagulation cascades_Homo sapiens_hsa046102.08071225
14Galactose metabolism_Homo sapiens_hsa000521.97611963
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96956165
16Fructose and mannose metabolism_Homo sapiens_hsa000511.92189798
17Histidine metabolism_Homo sapiens_hsa003401.80411076
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72173116
19Staphylococcus aureus infection_Homo sapiens_hsa051501.67103723
20Starch and sucrose metabolism_Homo sapiens_hsa005001.65584397
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60051627
22Linoleic acid metabolism_Homo sapiens_hsa005911.54062777
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49965143
24Glutathione metabolism_Homo sapiens_hsa004801.48187076
25Glycerolipid metabolism_Homo sapiens_hsa005611.45302378
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44878568
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.40903692
28* Thyroid hormone synthesis_Homo sapiens_hsa049181.36987853
29PPAR signaling pathway_Homo sapiens_hsa033201.36476083
30Arginine biosynthesis_Homo sapiens_hsa002201.33951812
31Folate biosynthesis_Homo sapiens_hsa007901.32836345
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23495528
33Vibrio cholerae infection_Homo sapiens_hsa051101.20607501
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.18740674
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.15686188
36Other glycan degradation_Homo sapiens_hsa005111.11905288
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.07722363
38Fatty acid elongation_Homo sapiens_hsa000621.04034211
39Tight junction_Homo sapiens_hsa045301.00304408
40Sphingolipid metabolism_Homo sapiens_hsa006000.98955953
41Sulfur relay system_Homo sapiens_hsa041220.96722613
42Ether lipid metabolism_Homo sapiens_hsa005650.96640625
43Arachidonic acid metabolism_Homo sapiens_hsa005900.95922655
44Tryptophan metabolism_Homo sapiens_hsa003800.95922452
45Arginine and proline metabolism_Homo sapiens_hsa003300.95186041
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93300233
47Pentose phosphate pathway_Homo sapiens_hsa000300.89961028
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89185632
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83767572
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.79621090
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79248732
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76358785
53Fatty acid degradation_Homo sapiens_hsa000710.75574333
54Peroxisome_Homo sapiens_hsa041460.75549006
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73805196
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73600304
57Lysosome_Homo sapiens_hsa041420.72882102
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72504462
59Asthma_Homo sapiens_hsa053100.70134705
60Salmonella infection_Homo sapiens_hsa051320.69469107
61Pancreatic secretion_Homo sapiens_hsa049720.67801979
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67488928
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65634748
64Thyroid cancer_Homo sapiens_hsa052160.64445363
65Gastric acid secretion_Homo sapiens_hsa049710.64420786
66Bladder cancer_Homo sapiens_hsa052190.62333908
67Rheumatoid arthritis_Homo sapiens_hsa053230.61843882
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61596753
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.60878542
70African trypanosomiasis_Homo sapiens_hsa051430.58608515
71GnRH signaling pathway_Homo sapiens_hsa049120.58349698
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57675735
73Carbon metabolism_Homo sapiens_hsa012000.54309708
74Hepatitis C_Homo sapiens_hsa051600.53952819
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53455587
76Adherens junction_Homo sapiens_hsa045200.51494778
77Type I diabetes mellitus_Homo sapiens_hsa049400.50656061
78VEGF signaling pathway_Homo sapiens_hsa043700.48674163
79Salivary secretion_Homo sapiens_hsa049700.48563732
80ABC transporters_Homo sapiens_hsa020100.48539833
81Toxoplasmosis_Homo sapiens_hsa051450.45061635
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44984831
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42065476
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41391230
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41139056
86Autoimmune thyroid disease_Homo sapiens_hsa053200.41130101
87Choline metabolism in cancer_Homo sapiens_hsa052310.40333068
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40167433
89Pyruvate metabolism_Homo sapiens_hsa006200.39990925
90Small cell lung cancer_Homo sapiens_hsa052220.39444452
91Vitamin B6 metabolism_Homo sapiens_hsa007500.39158255
92Amoebiasis_Homo sapiens_hsa051460.38492685
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37803821
94beta-Alanine metabolism_Homo sapiens_hsa004100.37677641
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37256047
96Legionellosis_Homo sapiens_hsa051340.37028686
97Type II diabetes mellitus_Homo sapiens_hsa049300.36122893
98N-Glycan biosynthesis_Homo sapiens_hsa005100.35156882
99Pertussis_Homo sapiens_hsa051330.32651339
100Steroid biosynthesis_Homo sapiens_hsa001000.32567052
101Long-term depression_Homo sapiens_hsa047300.31048656
102Chemical carcinogenesis_Homo sapiens_hsa052040.28770395
103Allograft rejection_Homo sapiens_hsa053300.28561916
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28125915
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.27129050
106Retinol metabolism_Homo sapiens_hsa008300.24240014
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23091155
108Biosynthesis of amino acids_Homo sapiens_hsa012300.22655133
109Graft-versus-host disease_Homo sapiens_hsa053320.20165643
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.19931464
111Fatty acid metabolism_Homo sapiens_hsa012120.19741144
112Fatty acid biosynthesis_Homo sapiens_hsa000610.18139331
113Nitrogen metabolism_Homo sapiens_hsa009100.18033476
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.17506605
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17236389
116Metabolic pathways_Homo sapiens_hsa011000.16712084
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16425978
118Collecting duct acid secretion_Homo sapiens_hsa049660.16011049
119TNF signaling pathway_Homo sapiens_hsa046680.15729861
120Ovarian steroidogenesis_Homo sapiens_hsa049130.15415138
121Shigellosis_Homo sapiens_hsa051310.15247199
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14956803
123ECM-receptor interaction_Homo sapiens_hsa045120.14781206
124Influenza A_Homo sapiens_hsa051640.14503718
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14419463
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12444538
127HIF-1 signaling pathway_Homo sapiens_hsa040660.11783908
128Dorso-ventral axis formation_Homo sapiens_hsa043200.10612067
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.10361562
130Butanoate metabolism_Homo sapiens_hsa006500.09776381
131Leishmaniasis_Homo sapiens_hsa051400.09430536

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