DUS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of helicase activity (GO:0051095)4.86517860
2DNA deamination (GO:0045006)4.75339542
3regulation of MHC class II biosynthetic process (GO:0045346)4.74183443
4negative regulation of telomerase activity (GO:0051974)4.43694709
5positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.14328464
6regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.14328464
7positive regulation of chemokine biosynthetic process (GO:0045080)4.10131683
8regulation of telomere maintenance via telomerase (GO:0032210)4.04985109
9negative regulation of telomere maintenance (GO:0032205)4.02987401
10regulation of chemokine biosynthetic process (GO:0045073)4.01429834
11regulation of nuclear cell cycle DNA replication (GO:0033262)3.99801289
12positive regulation of gamma-delta T cell activation (GO:0046645)3.97175328
13transcription elongation from RNA polymerase III promoter (GO:0006385)3.93993704
14termination of RNA polymerase III transcription (GO:0006386)3.93993704
15respiratory burst (GO:0045730)3.86852389
16cellular response to exogenous dsRNA (GO:0071360)3.77416838
17DNA damage response, detection of DNA damage (GO:0042769)3.74738292
18proteasome assembly (GO:0043248)3.65737613
19defense response to protozoan (GO:0042832)3.58829070
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.52208269
21ribosome assembly (GO:0042255)3.48495380
22tRNA methylation (GO:0030488)3.46993783
23purine nucleobase biosynthetic process (GO:0009113)3.46954663
24pseudouridine synthesis (GO:0001522)3.38555616
25nucleobase biosynthetic process (GO:0046112)3.38410709
26mitotic metaphase plate congression (GO:0007080)3.34736377
27ribosome biogenesis (GO:0042254)3.27389797
28regulation of MHC class I biosynthetic process (GO:0045343)3.25803986
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20095217
307-methylguanosine mRNA capping (GO:0006370)3.16456796
31maturation of 5.8S rRNA (GO:0000460)3.15394492
32telomere maintenance via telomerase (GO:0007004)3.15380775
33endosome to melanosome transport (GO:0035646)3.09037054
34endosome to pigment granule transport (GO:0043485)3.09037054
357-methylguanosine RNA capping (GO:0009452)3.08041984
36RNA capping (GO:0036260)3.08041984
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07594290
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06992094
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06992094
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06992094
41RNA-dependent DNA replication (GO:0006278)3.06556981
42telomere maintenance via telomere lengthening (GO:0010833)3.05322847
43NAD biosynthetic process (GO:0009435)3.04650780
44protein deneddylation (GO:0000338)3.03495795
45transcription from RNA polymerase I promoter (GO:0006360)3.02848394
46response to protozoan (GO:0001562)3.02799063
47IMP biosynthetic process (GO:0006188)3.02102967
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01486386
49DNA damage induced protein phosphorylation (GO:0006975)3.01199385
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00753348
51DNA replication checkpoint (GO:0000076)3.00460820
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98344452
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98344452
54formation of translation preinitiation complex (GO:0001731)2.96448894
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95775803
56signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94613237
57signal transduction involved in DNA damage checkpoint (GO:0072422)2.94613237
58DNA replication initiation (GO:0006270)2.94611093
59signal transduction involved in cell cycle checkpoint (GO:0072395)2.93309758
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93150098
61rRNA modification (GO:0000154)2.92402928
62regulation of isotype switching to IgG isotypes (GO:0048302)2.89116880
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89075472
64peptidyl-arginine omega-N-methylation (GO:0035247)2.88558331
65telomere maintenance via semi-conservative replication (GO:0032201)2.87996554
66positive regulation of protein homodimerization activity (GO:0090073)2.87233068
67regulation of cellular amino acid metabolic process (GO:0006521)2.86944547
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81700036
69protein maturation by protein folding (GO:0022417)2.81310766
70DNA strand elongation involved in DNA replication (GO:0006271)2.80943109
71termination of RNA polymerase I transcription (GO:0006363)2.77348513
72mismatch repair (GO:0006298)2.76953001
73DNA strand elongation (GO:0022616)2.75784027
74regulation of telomerase activity (GO:0051972)2.74412009
75positive regulation of DNA recombination (GO:0045911)2.73469908
76Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72551177
77positive regulation of humoral immune response (GO:0002922)2.71368193
78positive regulation by symbiont of host defense response (GO:0052509)2.69810800
79modulation by symbiont of host defense response (GO:0052031)2.69810800
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69810800
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69810800
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.69810800
83modulation by symbiont of host immune response (GO:0052553)2.69810800
84cellular response to dsRNA (GO:0071359)2.68741782
85regulation of regulatory T cell differentiation (GO:0045589)2.68697887
86cullin deneddylation (GO:0010388)2.68263799
87antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.68032068
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67306988
89negative regulation of ligase activity (GO:0051352)2.67306988
90regulation of protein heterodimerization activity (GO:0043497)2.66980838
91DNA-dependent DNA replication (GO:0006261)2.66101467
92sequestering of actin monomers (GO:0042989)2.65713055
93mitotic nuclear envelope disassembly (GO:0007077)2.63387338
94IMP metabolic process (GO:0046040)2.63268587
95L-methionine salvage (GO:0071267)2.63103608
96L-methionine biosynthetic process (GO:0071265)2.63103608
97amino acid salvage (GO:0043102)2.63103608
98RNA methylation (GO:0001510)2.62971561
99mitotic sister chromatid segregation (GO:0000070)2.62623763
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62505995
101ribosomal small subunit assembly (GO:0000028)2.61890789
102* tRNA processing (GO:0008033)2.61580120
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.61472324
104telomere maintenance via recombination (GO:0000722)2.61232689
105tRNA aminoacylation for protein translation (GO:0006418)2.60821639
106chromatin remodeling at centromere (GO:0031055)2.59538429
107CENP-A containing nucleosome assembly (GO:0034080)2.59454547
108DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.59322815
109rRNA methylation (GO:0031167)2.59024867
110transcription initiation from RNA polymerase I promoter (GO:0006361)2.58446075
111* tRNA metabolic process (GO:0006399)2.57973214
112positive regulation of B cell differentiation (GO:0045579)2.57389357
113chaperone-mediated protein transport (GO:0072321)2.57272560
114regulation of interleukin-12 biosynthetic process (GO:0045075)2.55924884
115metaphase plate congression (GO:0051310)2.55667362
116regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.55380875
117transcription-coupled nucleotide-excision repair (GO:0006283)2.54947843
118replication fork processing (GO:0031297)2.52314087
119tRNA aminoacylation (GO:0043039)2.52220892
120amino acid activation (GO:0043038)2.52220892
121regulation of gamma-delta T cell activation (GO:0046643)2.51987065
122telomere maintenance (GO:0000723)2.51149612
123* tRNA modification (GO:0006400)2.50957835
124positive regulation of immunoglobulin mediated immune response (GO:0002891)2.50276792
125positive regulation of B cell mediated immunity (GO:0002714)2.50276792
126regulation of translation in response to stress (GO:0043555)2.50155287
127positive regulation of ligase activity (GO:0051351)2.50142458
128positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50078043
129telomere organization (GO:0032200)2.49725942
130nucleobase-containing small molecule interconversion (GO:0015949)2.49432452
131DNA catabolic process, exonucleolytic (GO:0000738)2.48253971
132B cell mediated immunity (GO:0019724)2.47971328
133methionine biosynthetic process (GO:0009086)2.47907364
134immunoglobulin mediated immune response (GO:0016064)2.47735571
135positive regulation of interleukin-1 secretion (GO:0050716)2.47581509
136transcription elongation from RNA polymerase I promoter (GO:0006362)2.47527824
137detection of bacterium (GO:0016045)2.47107841
138mitotic recombination (GO:0006312)2.46420760
139pentose metabolic process (GO:0019321)2.46293017
140spliceosomal snRNP assembly (GO:0000387)2.45683340
141protein targeting to mitochondrion (GO:0006626)2.45550864
142single strand break repair (GO:0000012)2.45184123
143positive regulation of natural killer cell mediated immunity (GO:0002717)2.44679014
144positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.44679014
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.44498107
146negative regulation of metanephros development (GO:0072217)2.44030418
147histone arginine methylation (GO:0034969)2.43630638
148regulation of mitochondrial translation (GO:0070129)2.43343930
149pyrimidine-containing compound salvage (GO:0008655)2.43270657
150pyrimidine nucleoside salvage (GO:0043097)2.43270657
151peptidyl-arginine N-methylation (GO:0035246)2.42280611
152peptidyl-arginine methylation (GO:0018216)2.42280611
153regulation of ubiquitin-protein transferase activity (GO:0051438)2.41472827
154DNA ligation (GO:0006266)2.41367970
155peptidyl-histidine modification (GO:0018202)2.40807215
156nuclear envelope disassembly (GO:0051081)2.40161518
157membrane disassembly (GO:0030397)2.40161518
158heterochromatin organization (GO:0070828)2.38995359
159regulation of B cell receptor signaling pathway (GO:0050855)2.38579679
160establishment of integrated proviral latency (GO:0075713)2.37723030
161negative regulation of chromosome segregation (GO:0051985)2.37418347
162neutrophil activation involved in immune response (GO:0002283)2.35972308
163mitotic spindle assembly checkpoint (GO:0007094)2.35689697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.31142510
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36172512
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.79219204
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73488523
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.64877712
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.13563057
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.05398118
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78824582
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77392743
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73326463
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61549352
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.60545422
13VDR_23849224_ChIP-Seq_CD4+_Human2.56634263
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.55559357
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.51948064
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49234030
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48168700
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48157596
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41811973
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.33898455
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33859148
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.28013280
23FOXP3_21729870_ChIP-Seq_TREG_Human2.23555374
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23455361
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18890782
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18875813
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13362832
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06115191
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03984984
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01246444
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99111358
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95751684
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94702960
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90410344
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87424324
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84446209
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.80034095
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79570102
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.79406091
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79137185
41MYC_22102868_ChIP-Seq_BL_Human1.78154589
42DCP1A_22483619_ChIP-Seq_HELA_Human1.77876543
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77647632
44ELK1_19687146_ChIP-ChIP_HELA_Human1.69052908
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68082782
46GABP_19822575_ChIP-Seq_HepG2_Human1.64468304
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64251314
48VDR_21846776_ChIP-Seq_THP-1_Human1.57580827
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53720794
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53314028
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52447702
52XRN2_22483619_ChIP-Seq_HELA_Human1.49471165
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48902841
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45672095
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.44142321
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42907486
57CIITA_25753668_ChIP-Seq_RAJI_Human1.42219868
58SPI1_23547873_ChIP-Seq_NB4_Human1.41957269
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41473375
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38344440
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36188500
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34869640
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34112327
64IRF1_19129219_ChIP-ChIP_H3396_Human1.32299704
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30693904
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30455628
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30036518
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29850962
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28706272
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26308294
71MAF_26560356_Chip-Seq_TH2_Human1.25062884
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22283009
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.19476756
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18228266
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17526313
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.16781636
77TTF2_22483619_ChIP-Seq_HELA_Human1.15554980
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14352262
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14159184
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13136591
81MAF_26560356_Chip-Seq_TH1_Human1.11758285
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11173748
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09215093
84UTX_26944678_Chip-Seq_JUKART_Human1.09141277
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08309603
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08090401
87MYC_18940864_ChIP-ChIP_HL60_Human1.05328666
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03612547
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.03606721
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03067635
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02667876
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02478614
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02454094
94KDM5A_27292631_Chip-Seq_BREAST_Human1.01117802
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.98893846
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96797645
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95562426
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95144733
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.94127348
100MYB_26560356_Chip-Seq_TH2_Human0.93369835
101BCL6_27268052_Chip-Seq_Bcells_Human0.92948511
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92107530
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91440610
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90112523
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90092197
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89797909
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89362996
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88582002
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88042650
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87345076
111ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87203456
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86393760
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82724212
114IRF8_27001747_Chip-Seq_BMDM_Mouse0.82064474
115MYB_26560356_Chip-Seq_TH1_Human0.81061801
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78910059
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77635008
118TFEB_21752829_ChIP-Seq_HELA_Human0.77570699
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76614963
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.74268424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.05938848
2MP0001835_abnormal_antigen_presentation3.74489141
3MP0006292_abnormal_olfactory_placode3.43997069
4MP0003693_abnormal_embryo_hatching3.09485378
5MP0009785_altered_susceptibility_to3.07709718
6MP0010094_abnormal_chromosome_stability2.92848345
7MP0003111_abnormal_nucleus_morphology2.89032475
8MP0008058_abnormal_DNA_repair2.74662734
9MP0008057_abnormal_DNA_replication2.71295119
10MP0009333_abnormal_splenocyte_physiolog2.70533555
11MP0003763_abnormal_thymus_physiology2.53767327
12MP0001873_stomach_inflammation2.23719848
13MP0001800_abnormal_humoral_immune2.21670589
14MP0003077_abnormal_cell_cycle2.18570162
15MP0001529_abnormal_vocalization2.17829201
16MP0005000_abnormal_immune_tolerance2.16145382
17MP0003186_abnormal_redox_activity2.14059734
18MP0003303_peritoneal_inflammation1.99583267
19MP0008877_abnormal_DNA_methylation1.99206422
20MP0005025_abnormal_response_to1.99034802
21MP0002398_abnormal_bone_marrow1.97237710
22MP0002420_abnormal_adaptive_immunity1.94818010
23MP0002452_abnormal_antigen_presenting1.93635356
24MP0001819_abnormal_immune_cell1.92918023
25MP0001188_hyperpigmentation1.92887235
26MP0002723_abnormal_immune_serum1.91946762
27MP0001790_abnormal_immune_system1.87465058
28MP0005387_immune_system_phenotype1.87465058
29MP0005075_abnormal_melanosome_morpholog1.85148546
30MP0005451_abnormal_body_composition1.83887131
31MP0002419_abnormal_innate_immunity1.82696320
32MP0002148_abnormal_hypersensitivity_rea1.78968622
33MP0001984_abnormal_olfaction1.73534291
34MP0003806_abnormal_nucleotide_metabolis1.71809283
35MP0005058_abnormal_lysosome_morphology1.71420925
36MP0000685_abnormal_immune_system1.71408515
37MP0002102_abnormal_ear_morphology1.70629857
38MP0006082_CNS_inflammation1.69659198
39MP0008260_abnormal_autophagy1.66714104
40MP0000716_abnormal_immune_system1.65888592
41MP0002163_abnormal_gland_morphology1.65691832
42MP0000689_abnormal_spleen_morphology1.65629955
43MP0003787_abnormal_imprinting1.64680006
44MP0002722_abnormal_immune_system1.58630695
45MP0003718_maternal_effect1.53250399
46MP0000358_abnormal_cell_content/1.51801740
47MP0004957_abnormal_blastocyst_morpholog1.50893244
48MP0002429_abnormal_blood_cell1.48599252
49MP0003221_abnormal_cardiomyocyte_apopto1.47506087
50MP0001986_abnormal_taste_sensitivity1.46537918
51MP0002876_abnormal_thyroid_physiology1.45903325
52MP0003724_increased_susceptibility_to1.45109138
53MP0002132_abnormal_respiratory_system1.44500954
54MP0003436_decreased_susceptibility_to1.41257244
55MP0005310_abnormal_salivary_gland1.41072186
56MP0008007_abnormal_cellular_replicative1.39392493
57MP0002277_abnormal_respiratory_mucosa1.39335840
58MP0004147_increased_porphyrin_level1.36613556
59MP0000703_abnormal_thymus_morphology1.36008007
60MP0005410_abnormal_fertilization1.33627841
61MP0001730_embryonic_growth_arrest1.32128926
62MP0005670_abnormal_white_adipose1.32061183
63MP0000465_gastrointestinal_hemorrhage1.30322770
64MP0002405_respiratory_system_inflammati1.30215616
65MP0009697_abnormal_copulation1.28868267
66MP0003786_premature_aging1.28524560
67MP0001845_abnormal_inflammatory_respons1.28369862
68MP0001764_abnormal_homeostasis1.28053856
69MP0002396_abnormal_hematopoietic_system1.26574877
70MP0008995_early_reproductive_senescence1.24433752
71MP0000350_abnormal_cell_proliferation1.19065940
72MP0010386_abnormal_urinary_bladder1.18112763
73MP0008932_abnormal_embryonic_tissue1.16167255
74MP0005379_endocrine/exocrine_gland_phen1.15981534
75MP0010155_abnormal_intestine_physiology1.12902875
76MP0001853_heart_inflammation1.10396574
77MP0005464_abnormal_platelet_physiology1.09539473
78MP0010307_abnormal_tumor_latency1.08535042
79MP0000015_abnormal_ear_pigmentation1.08114021
80MP0008469_abnormal_protein_level1.07513845
81MP0000490_abnormal_crypts_of1.04552962
82MP0002019_abnormal_tumor_incidence0.99212548
83MP0006036_abnormal_mitochondrial_physio0.99068377
84MP0005084_abnormal_gallbladder_morpholo0.97837981
85MP0001727_abnormal_embryo_implantation0.97039907
86MP0002080_prenatal_lethality0.96837551
87MP0005319_abnormal_enzyme/_coenzyme0.95662483
88MP0009764_decreased_sensitivity_to0.92565087
89MP0000858_altered_metastatic_potential0.91076520
90MP0003866_abnormal_defecation0.90847253
91MP0008789_abnormal_olfactory_epithelium0.90747670
92MP0005646_abnormal_pituitary_gland0.90740062
93MP0005499_abnormal_olfactory_system0.89139482
94MP0005394_taste/olfaction_phenotype0.89139482
95MP0001119_abnormal_female_reproductive0.88390651
96MP0008874_decreased_physiological_sensi0.88266314
97MP0000566_synostosis0.87716795
98MP0005389_reproductive_system_phenotype0.86532763
99MP0002210_abnormal_sex_determination0.84603428
100MP0006035_abnormal_mitochondrial_morpho0.84454954
101MP0003172_abnormal_lysosome_physiology0.83642763
102MP0001697_abnormal_embryo_size0.82860254
103MP0000313_abnormal_cell_death0.81760314
104MP0002933_joint_inflammation0.80706626
105MP0003011_delayed_dark_adaptation0.79736115
106MP0005384_cellular_phenotype0.79146229
107MP0003183_abnormal_peptide_metabolism0.79099784
108MP0009765_abnormal_xenobiotic_induced0.78867602
109MP0005257_abnormal_intraocular_pressure0.77852944
110MP0002138_abnormal_hepatobiliary_system0.77661985
111MP0000343_altered_response_to0.77431489
112MP0003448_altered_tumor_morphology0.76345272
113MP0002160_abnormal_reproductive_system0.75281269
114MP0003191_abnormal_cellular_cholesterol0.74985552
115MP0002127_abnormal_cardiovascular_syste0.73722861
116MP0000749_muscle_degeneration0.73435516
117MP0004883_abnormal_blood_vessel0.72907632
118MP0001905_abnormal_dopamine_level0.72524201
119MP0005380_embryogenesis_phenotype0.72466135
120MP0001672_abnormal_embryogenesis/_devel0.72466135
121MP0004808_abnormal_hematopoietic_stem0.72403121
122MP0005330_cardiomyopathy0.70723122
123MP0009763_increased_sensitivity_to0.70636321
124MP0002653_abnormal_ependyma_morphology0.69443735
125MP0002638_abnormal_pupillary_reflex0.69224007
126MP0001919_abnormal_reproductive_system0.65594789
127MP0001145_abnormal_male_reproductive0.65576191
128MP0005645_abnormal_hypothalamus_physiol0.64202692
129MP0004133_heterotaxia0.64175349
130MP0001542_abnormal_bone_strength0.63807750
131MP0001929_abnormal_gametogenesis0.63719256
132MP0002693_abnormal_pancreas_physiology0.62248354

Predicted human phenotypes

RankGene SetZ-score
1Type 2 muscle fiber atrophy (HP:0003554)5.00184677
2Muscle fiber atrophy (HP:0100295)4.47603679
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30376359
4Increased serum pyruvate (HP:0003542)4.05898635
5Birth length less than 3rd percentile (HP:0003561)3.88502147
6Chromsome breakage (HP:0040012)3.87388374
7Abnormality of glycolysis (HP:0004366)3.83727066
8IgM deficiency (HP:0002850)3.77288877
9Recurrent bacterial skin infections (HP:0005406)3.71117449
10Hypokinesia (HP:0002375)3.47177161
11Ragged-red muscle fibers (HP:0003200)3.28729495
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.19477084
13Panhypogammaglobulinemia (HP:0003139)3.08340631
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.06498506
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.05979142
16Eczematoid dermatitis (HP:0000976)3.01162369
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98408497
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98408497
19Recurrent cutaneous fungal infections (HP:0011370)2.97028110
20Chronic mucocutaneous candidiasis (HP:0002728)2.97028110
21Obstructive lung disease (HP:0006536)2.95606631
22Chronic obstructive pulmonary disease (HP:0006510)2.95606631
23Abnormality of the renal collecting system (HP:0004742)2.95523571
24Abnormality of the preputium (HP:0100587)2.94136708
25Duplicated collecting system (HP:0000081)2.88367470
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.82098341
27Type I transferrin isoform profile (HP:0003642)2.78854493
28Agammaglobulinemia (HP:0004432)2.76119897
29Meckel diverticulum (HP:0002245)2.72468085
30Optic neuritis (HP:0100653)2.64982342
31Retrobulbar optic neuritis (HP:0100654)2.64982342
32Abnormality of T cell physiology (HP:0011840)2.64612229
33Abnormality of the ileum (HP:0001549)2.62695716
34Progressive external ophthalmoplegia (HP:0000590)2.59471130
35Abnormality of T cells (HP:0002843)2.57627024
36Colitis (HP:0002583)2.57011004
37Myositis (HP:0100614)2.51497481
38Recurrent viral infections (HP:0004429)2.51386354
39Abnormality of chromosome stability (HP:0003220)2.51346822
40Neutropenia (HP:0001875)2.49558028
413-Methylglutaconic aciduria (HP:0003535)2.49033649
42Abnormal gallbladder physiology (HP:0012438)2.48041755
43Cholecystitis (HP:0001082)2.48041755
44Abnormality of DNA repair (HP:0003254)2.47797720
45Increased IgM level (HP:0003496)2.47696926
46Amniotic constriction ring (HP:0009775)2.46664418
47Abnormality of placental membranes (HP:0011409)2.46664418
48Microvesicular hepatic steatosis (HP:0001414)2.45140855
49Acute necrotizing encephalopathy (HP:0006965)2.43372462
50Squamous cell carcinoma (HP:0002860)2.42769967
51Encephalitis (HP:0002383)2.41230103
52Aplastic anemia (HP:0001915)2.40869050
53Bone marrow hypocellularity (HP:0005528)2.40098023
54Amaurosis fugax (HP:0100576)2.39914619
55IgG deficiency (HP:0004315)2.38602625
56Esophageal atresia (HP:0002032)2.38390320
57Hepatic necrosis (HP:0002605)2.36506302
58Gastrointestinal stroma tumor (HP:0100723)2.34809747
59Clubbing of toes (HP:0100760)2.34580491
60Reduced antithrombin III activity (HP:0001976)2.33797002
61Alveolar cell carcinoma (HP:0006519)2.32577509
62Lymphoma (HP:0002665)2.29478772
63Prolonged neonatal jaundice (HP:0006579)2.28325615
64Abnormal mitochondria in muscle tissue (HP:0008316)2.27491596
65Recurrent abscess formation (HP:0002722)2.27141445
66Pancytopenia (HP:0001876)2.22739824
67Cellular immunodeficiency (HP:0005374)2.22460933
68Meningitis (HP:0001287)2.21530314
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19259192
70Orchitis (HP:0100796)2.19190469
71Recurrent sinusitis (HP:0011108)2.18817044
72Abnormality of the prostate (HP:0008775)2.18736601
73Respiratory difficulties (HP:0002880)2.18155866
74Cerebral hypomyelination (HP:0006808)2.17879598
75Rough bone trabeculation (HP:0100670)2.17015569
76Abnormal protein glycosylation (HP:0012346)2.16532632
77Abnormal glycosylation (HP:0012345)2.16532632
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16532632
79Abnormal protein N-linked glycosylation (HP:0012347)2.16532632
80Recurrent gram-negative bacterial infections (HP:0005420)2.15396684
81Recurrent fungal infections (HP:0002841)2.14735992
82Leukopenia (HP:0001882)2.14013271
83Stomatitis (HP:0010280)2.12729583
84Hepatosplenomegaly (HP:0001433)2.12237910
85Prostate neoplasm (HP:0100787)2.12106162
86Myelodysplasia (HP:0002863)2.11990904
87Urticaria (HP:0001025)2.11889273
88Pancreatic cysts (HP:0001737)2.08115359
89Increased serum lactate (HP:0002151)2.06234746
90Anorexia (HP:0002039)2.06223326
91Abnormality of pyrimidine metabolism (HP:0004353)2.06180106
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05426519
93Lactic acidosis (HP:0003128)2.03800424
94Hepatocellular necrosis (HP:0001404)2.03643184
95Chronic diarrhea (HP:0002028)2.02833349
96Hypomagnesemia (HP:0002917)2.02485101
97True hermaphroditism (HP:0010459)2.01283828
98Hypoplasia of the thymus (HP:0000778)2.00408618
99Abnormality of magnesium homeostasis (HP:0004921)2.00268954
100Carpal bone hypoplasia (HP:0001498)2.00071371
101Increased connective tissue (HP:0009025)1.99893078
102Elevated erythrocyte sedimentation rate (HP:0003565)1.99414755
103Progressive muscle weakness (HP:0003323)1.99170194
104Renal Fanconi syndrome (HP:0001994)1.97106564
105Cutaneous melanoma (HP:0012056)1.96339860
106Granulocytopenia (HP:0001913)1.95517500
107Mitochondrial inheritance (HP:0001427)1.95140239
108IgA deficiency (HP:0002720)1.95113589
109Basal cell carcinoma (HP:0002671)1.95100806
110Pustule (HP:0200039)1.94585544
111Mediastinal lymphadenopathy (HP:0100721)1.94119426
112Recurrent skin infections (HP:0001581)1.93777243
113Multiple enchondromatosis (HP:0005701)1.92785594
114Lymphopenia (HP:0001888)1.92336010
115Cellulitis (HP:0100658)1.91195526
116Aplasia/Hypoplasia of the thymus (HP:0010515)1.90613695
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89602053
118Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87580709
119Progressive macrocephaly (HP:0004481)1.87450458
120Duodenal stenosis (HP:0100867)1.86941916
121Small intestinal stenosis (HP:0012848)1.86941916
122Oral leukoplakia (HP:0002745)1.86354967
123Acute encephalopathy (HP:0006846)1.85892940
124Vasculitis (HP:0002633)1.82992661
125Increased CSF lactate (HP:0002490)1.82858791
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.82729379
127Abnormality of macrophages (HP:0004311)1.80215840
128Abnormality of B cell number (HP:0010975)1.80058220
129B lymphocytopenia (HP:0010976)1.80058220
130Neoplasm of the tracheobronchial system (HP:0100552)1.79862714
131Petechiae (HP:0000967)1.79656967
132Inflammation of the large intestine (HP:0002037)1.79586173
133Gastrointestinal inflammation (HP:0004386)1.76156409
134T lymphocytopenia (HP:0005403)1.75690187
135Degeneration of anterior horn cells (HP:0002398)1.73722281
136Abnormality of the anterior horn cell (HP:0006802)1.73722281
137Optic nerve coloboma (HP:0000588)1.73543883
138Absent radius (HP:0003974)1.72634685
139Pancreatic fibrosis (HP:0100732)1.72460273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.00692275
2STK163.48272350
3IRAK33.13513747
4ZAK3.05635292
5EIF2AK32.71651322
6MAP3K52.60192380
7PLK42.57604946
8TAOK22.48529630
9MAP4K12.42392609
10IRAK42.41461299
11BUB12.41002656
12TAOK32.31532309
13RIPK42.26691810
14EIF2AK12.15848533
15MAP3K122.10478775
16TSSK62.06307668
17VRK22.02713037
18MAP3K142.02430284
19SMG11.85460327
20PIK3CA1.73770918
21SRPK11.65848500
22WEE11.65794587
23NME21.65151941
24CDC71.64329119
25MAP4K21.62120276
26NEK11.51747982
27TESK21.51504524
28CASK1.50974209
29MAP3K111.49793628
30FES1.47258565
31VRK11.46715908
32CDK191.41713303
33PBK1.39303536
34ZAP701.37822704
35JAK31.36462216
36TIE11.34700188
37BMPR21.33779027
38SIK21.31660588
39BLK1.31645533
40CCNB11.30061678
41IKBKE1.25915807
42NEK91.24780720
43EIF2AK21.21623858
44MAP2K61.20269273
45MAP2K31.19665202
46BCKDK1.18948241
47GRK61.15388447
48INSRR1.14483502
49YES11.12522383
50MAP2K71.12398950
51PRPF4B1.11743165
52TTK1.11324988
53PIM21.11117668
54SYK1.11079022
55TESK11.10484500
56MUSK1.06829149
57ATR1.05610395
58MARK31.02741687
59TLK11.01026130
60TNK21.00234733
61CSK1.00011076
62AKT30.99963079
63PASK0.98645597
64ARAF0.98097170
65FGFR40.95721421
66STK40.95146683
67MKNK20.93887829
68PLK30.93239891
69IKBKB0.91961684
70MST1R0.91535999
71NEK60.91411934
72ACVR1B0.89624084
73PLK10.88244155
74KIT0.85413429
75CSNK1G30.85143770
76TBK10.83624340
77PDK20.82507417
78FGR0.82380453
79BTK0.82219359
80MKNK10.80514000
81ADRBK20.79815538
82NME10.79144728
83LYN0.78777987
84SGK20.76499285
85ERN10.74604303
86PINK10.72916506
87RPS6KA50.72557650
88IRAK10.71881137
89SIK30.68942981
90CHEK20.67653167
91CDC42BPA0.67196143
92LCK0.66501669
93AURKB0.64302474
94IRAK20.64033426
95TEC0.62192058
96TAF10.61026525
97PAK40.60993086
98CDK30.59690786
99ITK0.59633022
100STK240.58761908
101PIM10.58066341
102EPHB10.56739750
103MAP3K80.56398742
104BRSK20.53186983
105TYK20.53024164
106HCK0.50657651
107NUAK10.50547881
108MAPKAPK50.49349870
109TGFBR10.49297414
110BRSK10.49199024
111STK38L0.47230855
112AURKA0.45779276
113CSNK1A1L0.45492508
114DAPK10.44766950
115CHEK10.43598228
116PDK30.43417160
117PDK40.43417160
118CSNK2A10.42603663
119TRIM280.39809185
120CSF1R0.39483220
121CSNK1G20.39007178
122MAP3K30.38774687
123MAP3K10.38094156
124CDK70.37874071
125CHUK0.37784476
126NLK0.37500595
127MAPK110.36825697
128SCYL20.35754337
129PRKCQ0.35735722
130CSNK1G10.35732858
131PAK10.35716100
132TAOK10.35570652
133NEK20.35229344
134MELK0.34915927
135DYRK30.33611371
136RPS6KA40.33277636
137DAPK30.31884092
138PLK20.31792254
139KDR0.31752942
140DYRK20.31304966
141ATM0.31293055
142CSNK2A20.31231534
143STK100.31145484
144GRK70.30960041
145LIMK10.30788443
146RPS6KB10.30651339
147SGK30.30538791
148RAF10.29904362

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.23334389
2RNA polymerase_Homo sapiens_hsa030203.66751033
3DNA replication_Homo sapiens_hsa030303.07819676
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03152306
5Mismatch repair_Homo sapiens_hsa034302.99980302
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.60286390
7Graft-versus-host disease_Homo sapiens_hsa053322.58940280
8Homologous recombination_Homo sapiens_hsa034402.48489845
9Pyrimidine metabolism_Homo sapiens_hsa002402.47690877
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47043225
11Primary immunodeficiency_Homo sapiens_hsa053402.43477190
12Base excision repair_Homo sapiens_hsa034102.42398899
13Allograft rejection_Homo sapiens_hsa053302.32405414
14Fanconi anemia pathway_Homo sapiens_hsa034602.17704228
15Spliceosome_Homo sapiens_hsa030402.04246661
16Basal transcription factors_Homo sapiens_hsa030222.00926207
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.00429731
18One carbon pool by folate_Homo sapiens_hsa006701.95953753
19Nucleotide excision repair_Homo sapiens_hsa034201.74823802
20Antigen processing and presentation_Homo sapiens_hsa046121.72311731
21RNA transport_Homo sapiens_hsa030131.70406985
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68975785
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61532702
24Ribosome_Homo sapiens_hsa030101.58845807
25Measles_Homo sapiens_hsa051621.53863901
26RNA degradation_Homo sapiens_hsa030181.50764110
27Type I diabetes mellitus_Homo sapiens_hsa049401.48083309
28Regulation of autophagy_Homo sapiens_hsa041401.46619034
29Purine metabolism_Homo sapiens_hsa002301.43974324
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42217208
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.41417732
32Viral myocarditis_Homo sapiens_hsa054161.38590614
33Cell cycle_Homo sapiens_hsa041101.37845007
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31466007
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30807595
36Folate biosynthesis_Homo sapiens_hsa007901.30150180
37Epstein-Barr virus infection_Homo sapiens_hsa051691.29866501
38Herpes simplex infection_Homo sapiens_hsa051681.27430716
39Non-homologous end-joining_Homo sapiens_hsa034501.21894472
40Carbon metabolism_Homo sapiens_hsa012001.13514010
41Autoimmune thyroid disease_Homo sapiens_hsa053201.10438163
42Hematopoietic cell lineage_Homo sapiens_hsa046401.08870206
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08073172
44Leishmaniasis_Homo sapiens_hsa051401.07434810
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02451715
46Protein export_Homo sapiens_hsa030601.00862476
47T cell receptor signaling pathway_Homo sapiens_hsa046600.97635224
48Alcoholism_Homo sapiens_hsa050340.94283589
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92527816
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92459631
51Other glycan degradation_Homo sapiens_hsa005110.89669180
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.88491873
53Pentose phosphate pathway_Homo sapiens_hsa000300.87911098
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87834425
55Vitamin B6 metabolism_Homo sapiens_hsa007500.87124200
56p53 signaling pathway_Homo sapiens_hsa041150.85979583
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85871802
58Phagosome_Homo sapiens_hsa041450.85740788
59Rheumatoid arthritis_Homo sapiens_hsa053230.83993477
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82883872
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82812471
62Influenza A_Homo sapiens_hsa051640.80602027
63Sulfur relay system_Homo sapiens_hsa041220.77914204
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.77671001
65African trypanosomiasis_Homo sapiens_hsa051430.76607210
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74117300
67Legionellosis_Homo sapiens_hsa051340.72139638
68Staphylococcus aureus infection_Homo sapiens_hsa051500.72125044
69Alzheimers disease_Homo sapiens_hsa050100.71910330
70Oxidative phosphorylation_Homo sapiens_hsa001900.70346934
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70233565
72Malaria_Homo sapiens_hsa051440.69520448
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68018969
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67078480
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65942043
76Asthma_Homo sapiens_hsa053100.63161893
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63116700
78Huntingtons disease_Homo sapiens_hsa050160.55596983
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54324945
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53385776
81Pyruvate metabolism_Homo sapiens_hsa006200.53097479
82Viral carcinogenesis_Homo sapiens_hsa052030.52912601
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52434550
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51402680
85mRNA surveillance pathway_Homo sapiens_hsa030150.51328059
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50077211
87Apoptosis_Homo sapiens_hsa042100.48232367
88Acute myeloid leukemia_Homo sapiens_hsa052210.47913364
89Parkinsons disease_Homo sapiens_hsa050120.46968610
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.44535273
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44442152
92N-Glycan biosynthesis_Homo sapiens_hsa005100.44153530
93Oocyte meiosis_Homo sapiens_hsa041140.44068805
94Metabolic pathways_Homo sapiens_hsa011000.43209230
95Tuberculosis_Homo sapiens_hsa051520.42862016
96Selenocompound metabolism_Homo sapiens_hsa004500.42181548
97Steroid biosynthesis_Homo sapiens_hsa001000.39047247
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37277342
99Systemic lupus erythematosus_Homo sapiens_hsa053220.36444801
100Vitamin digestion and absorption_Homo sapiens_hsa049770.34285988
101Arachidonic acid metabolism_Homo sapiens_hsa005900.34244251
102Salmonella infection_Homo sapiens_hsa051320.33570835
103TNF signaling pathway_Homo sapiens_hsa046680.33203245
104Biosynthesis of amino acids_Homo sapiens_hsa012300.32838407
105beta-Alanine metabolism_Homo sapiens_hsa004100.32524942
106Arginine and proline metabolism_Homo sapiens_hsa003300.29132573
107Osteoclast differentiation_Homo sapiens_hsa043800.28878597
108Toxoplasmosis_Homo sapiens_hsa051450.27915903
109B cell receptor signaling pathway_Homo sapiens_hsa046620.26568771
110Hepatitis B_Homo sapiens_hsa051610.26038966
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26032812
112HTLV-I infection_Homo sapiens_hsa051660.25814969
113Fatty acid elongation_Homo sapiens_hsa000620.25190667
114Pertussis_Homo sapiens_hsa051330.25167601
115Galactose metabolism_Homo sapiens_hsa000520.24372770
116Glutathione metabolism_Homo sapiens_hsa004800.24286512
117Collecting duct acid secretion_Homo sapiens_hsa049660.23567221
118Fructose and mannose metabolism_Homo sapiens_hsa000510.22386065
119Shigellosis_Homo sapiens_hsa051310.19081384
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19046223
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18994130
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18967478

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