DUS3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.23725559
2maturation of SSU-rRNA (GO:0030490)4.43050206
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.12360600
4negative regulation of B cell apoptotic process (GO:0002903)4.02022442
5viral transcription (GO:0019083)3.97051168
6peptidyl-arginine omega-N-methylation (GO:0035247)3.94711910
7histone arginine methylation (GO:0034969)3.83575482
8negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.82678265
9ribosomal small subunit assembly (GO:0000028)3.80076972
10ribosome biogenesis (GO:0042254)3.74029715
11DNA strand elongation involved in DNA replication (GO:0006271)3.72012248
12translational termination (GO:0006415)3.71687617
13nucleobase biosynthetic process (GO:0046112)3.65986693
14negative regulation of erythrocyte differentiation (GO:0045647)3.64549787
15purine deoxyribonucleotide catabolic process (GO:0009155)3.61053912
16pyrimidine nucleotide catabolic process (GO:0006244)3.58824866
17deoxyribonucleotide catabolic process (GO:0009264)3.55205793
18negative regulation of RNA splicing (GO:0033119)3.55082866
19DNA strand elongation (GO:0022616)3.54093789
20formation of translation preinitiation complex (GO:0001731)3.53823977
21translational elongation (GO:0006414)3.51968380
22DNA replication checkpoint (GO:0000076)3.50616604
23translational initiation (GO:0006413)3.48720051
24purine nucleobase biosynthetic process (GO:0009113)3.48577182
25deoxyribose phosphate catabolic process (GO:0046386)3.44210725
26ribonucleoprotein complex biogenesis (GO:0022613)3.38380827
27ribosome assembly (GO:0042255)3.36875012
28L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.36482902
29tRNA methylation (GO:0030488)3.35527836
30positive regulation of RNA splicing (GO:0033120)3.33738412
31peptidyl-arginine methylation (GO:0018216)3.32574503
32peptidyl-arginine N-methylation (GO:0035246)3.32574503
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29216249
34positive regulation of B cell differentiation (GO:0045579)3.28998016
35DNA unwinding involved in DNA replication (GO:0006268)3.28623065
36GDP-mannose metabolic process (GO:0019673)3.27718125
37positive regulation of synapse maturation (GO:0090129)3.27196869
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.26534155
39spliceosomal complex assembly (GO:0000245)3.25950189
40histone H4-K12 acetylation (GO:0043983)3.25486612
41cellular protein complex disassembly (GO:0043624)3.25259220
42termination of RNA polymerase II transcription (GO:0006369)3.23541693
43nucleotide salvage (GO:0043173)3.22700299
44spliceosomal snRNP assembly (GO:0000387)3.22408584
45pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20253616
46telomere maintenance via semi-conservative replication (GO:0032201)3.18424702
47ribosomal small subunit biogenesis (GO:0042274)3.17762618
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.16109555
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16109555
50protein complex disassembly (GO:0043241)3.15344838
51RNA splicing, via transesterification reactions (GO:0000375)3.14569209
52mRNA splicing, via spliceosome (GO:0000398)3.13802258
53RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.13802258
54dosage compensation (GO:0007549)3.13338380
55spliceosomal tri-snRNP complex assembly (GO:0000244)3.13266199
56DNA replication initiation (GO:0006270)3.13022777
57negative regulation of mRNA processing (GO:0050686)3.11601888
58regulation of mitochondrial translation (GO:0070129)3.09586481
59pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.06786244
60viral mRNA export from host cell nucleus (GO:0046784)3.04139534
61rRNA processing (GO:0006364)3.03053226
62base-excision repair, AP site formation (GO:0006285)3.02974948
63pre-miRNA processing (GO:0031054)3.01394642
64macromolecular complex disassembly (GO:0032984)3.00988999
65histone H2A acetylation (GO:0043968)3.00972042
66ribosomal large subunit biogenesis (GO:0042273)2.97762348
67IMP biosynthetic process (GO:0006188)2.97341794
68mucosal-associated lymphoid tissue development (GO:0048537)2.97291715
69Peyers patch development (GO:0048541)2.97291715
70rRNA metabolic process (GO:0016072)2.97149782
71UV protection (GO:0009650)2.96460084
72Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95893929
73pseudouridine synthesis (GO:0001522)2.95402918
74negative regulation of DNA-templated transcription, elongation (GO:0032785)2.95293283
75mature B cell differentiation involved in immune response (GO:0002313)2.94835833
76purine nucleotide salvage (GO:0032261)2.94664418
77metallo-sulfur cluster assembly (GO:0031163)2.93953577
78iron-sulfur cluster assembly (GO:0016226)2.93953577
79positive thymic T cell selection (GO:0045059)2.93669328
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92315421
81viral life cycle (GO:0019058)2.87722860
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.85850029
83termination of RNA polymerase III transcription (GO:0006386)2.85850029
84negative regulation of microtubule polymerization (GO:0031115)2.83251307
85cotranslational protein targeting to membrane (GO:0006613)2.83219932
86regulation of translational termination (GO:0006449)2.83155986
873-UTR-mediated mRNA stabilization (GO:0070935)2.83007909
88protein targeting to ER (GO:0045047)2.82194307
89negative regulation of histone methylation (GO:0031061)2.82001652
90rRNA transcription (GO:0009303)2.80574423
912-deoxyribonucleotide metabolic process (GO:0009394)2.79683145
92DNA-templated transcription, termination (GO:0006353)2.76464103
93pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.76153219
94regulation of B cell apoptotic process (GO:0002902)2.73828760
95mitochondrion transport along microtubule (GO:0047497)2.73380013
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.73380013
97nuclear-transcribed mRNA catabolic process (GO:0000956)2.71865623
98NIK/NF-kappaB signaling (GO:0038061)2.70833099
99regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67898542
100protein localization to kinetochore (GO:0034501)2.67758414
101regulation of superoxide anion generation (GO:0032928)2.67434297
102positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.67173825
103response to peptidoglycan (GO:0032494)2.66599727
104deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.66585185
105establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66406615
106mitotic nuclear envelope reassembly (GO:0007084)2.66116338
107nuclear envelope reassembly (GO:0031468)2.66116338
108protein localization to endoplasmic reticulum (GO:0070972)2.66109231
109DNA replication-dependent nucleosome organization (GO:0034723)2.64775957
110DNA replication-dependent nucleosome assembly (GO:0006335)2.64775957
111pinocytosis (GO:0006907)2.64648407
112proline biosynthetic process (GO:0006561)2.64188991
113protein maturation by protein folding (GO:0022417)2.63918807
114negative regulation of mRNA metabolic process (GO:1903312)2.63541944
115modulation by virus of host process (GO:0019054)2.62469470
116locomotory exploration behavior (GO:0035641)2.62433483
117deoxyribose phosphate metabolic process (GO:0019692)2.61369193
118protein complex localization (GO:0031503)2.60932553
119transcription from mitochondrial promoter (GO:0006390)2.60148841
120ncRNA 3-end processing (GO:0043628)2.58851092
121cellular component biogenesis (GO:0044085)2.58543828
122intra-S DNA damage checkpoint (GO:0031573)2.58285383
123chaperone mediated protein folding requiring cofactor (GO:0051085)2.57797154
124histone H4-K5 acetylation (GO:0043981)2.57643896
125histone H4-K8 acetylation (GO:0043982)2.57643896
126synaptic vesicle maturation (GO:0016188)2.57605336
127folic acid metabolic process (GO:0046655)2.57537651
128telomere maintenance via telomere lengthening (GO:0010833)2.57083567
129RNA catabolic process (GO:0006401)2.56649574
130negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.56322114
131regulation of double-strand break repair via homologous recombination (GO:0010569)2.56031657
132mitotic metaphase plate congression (GO:0007080)2.55860422
133ribonucleoprotein complex assembly (GO:0022618)2.55800623
134mRNA catabolic process (GO:0006402)2.54917026
135RNA splicing (GO:0008380)2.54763298
136IMP metabolic process (GO:0046040)2.53662320
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.53069663
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52887327
139positive regulation of gamma-delta T cell activation (GO:0046645)2.52507223
140maturation of 5.8S rRNA (GO:0000460)2.51319824
141regulation of translation in response to stress (GO:0043555)2.51095451
142L-methionine salvage (GO:0071267)2.50827289
143L-methionine biosynthetic process (GO:0071265)2.50827289
144amino acid salvage (GO:0043102)2.50827289
145regulation of translational fidelity (GO:0006450)2.50674790
146* tRNA modification (GO:0006400)2.50146735
147ribonucleoprotein complex subunit organization (GO:0071826)2.49898672
148protein-DNA complex disassembly (GO:0032986)2.49533038
149nucleosome disassembly (GO:0006337)2.49533038
1502-deoxyribonucleotide biosynthetic process (GO:0009265)2.49253999
151deoxyribose phosphate biosynthetic process (GO:0046385)2.49253999
152regulation of short-term neuronal synaptic plasticity (GO:0048172)2.48840613
153DNA duplex unwinding (GO:0032508)2.48446065
154regulation of monocyte differentiation (GO:0045655)2.47526333
155base-excision repair (GO:0006284)2.46911488
156cellular response to interleukin-4 (GO:0071353)2.46885881
157purine deoxyribonucleotide metabolic process (GO:0009151)2.46719637
158RNA methylation (GO:0001510)2.43308405
159positive regulation of granulocyte differentiation (GO:0030854)2.42996482
160telomere maintenance via recombination (GO:0000722)2.41944035
161thymic T cell selection (GO:0045061)2.41561466
162autophagic vacuole fusion (GO:0000046)2.41267527
163negative regulation of cell size (GO:0045792)2.40508271
164negative regulation of myeloid cell apoptotic process (GO:0033033)2.40049858
165pentose metabolic process (GO:0019321)2.36567636
166guanosine-containing compound biosynthetic process (GO:1901070)2.35288607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12243135
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.81202100
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57049132
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08374128
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96859009
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93791001
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72395968
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.70427906
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63325198
10CIITA_25753668_ChIP-Seq_RAJI_Human2.56933759
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55807968
12MYC_22102868_ChIP-Seq_BL_Human2.54643943
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38359803
14XRN2_22483619_ChIP-Seq_HELA_Human2.29607983
15* EST1_17652178_ChIP-ChIP_JURKAT_Human2.27582211
16YY1_21170310_ChIP-Seq_MESCs_Mouse2.13498286
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.10991402
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03077990
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98503307
20NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92271936
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.90799113
22POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90516552
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86147030
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85251874
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81400153
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80337572
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79477705
28VDR_23849224_ChIP-Seq_CD4+_Human1.76722181
29* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72812385
30VDR_21846776_ChIP-Seq_THP-1_Human1.72780235
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71411600
32GABP_19822575_ChIP-Seq_HepG2_Human1.69561641
33SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.68111319
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67543888
35* TTF2_22483619_ChIP-Seq_HELA_Human1.66174212
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65534915
37* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64225749
38* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63739117
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.63131782
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62577325
41FOXP3_21729870_ChIP-Seq_TREG_Human1.60232644
42* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59617313
43VDR_24763502_ChIP-Seq_THP-1_Human1.59576484
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.58681938
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57210767
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56170038
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56002774
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55119041
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55065940
50ZNF263_19887448_ChIP-Seq_K562_Human1.55015558
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.53870746
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52409681
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51872480
54UTX_26944678_Chip-Seq_JUKART_Human1.50846286
55* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49350847
56MAF_26560356_Chip-Seq_TH1_Human1.49265802
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48221146
58* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47165863
59MAF_26560356_Chip-Seq_TH2_Human1.45831090
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45505734
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44261878
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42739502
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42519917
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41372354
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.40814701
66* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39991646
67* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39427246
68* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39177256
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.38868284
70DCP1A_22483619_ChIP-Seq_HELA_Human1.34462907
71KDM5A_27292631_Chip-Seq_BREAST_Human1.32890396
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32835036
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31986351
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29316968
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29093158
76* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26977205
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26643042
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26633253
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26228302
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.25424309
81SPI1_23547873_ChIP-Seq_NB4_Human1.25406502
82TCF7_22412390_ChIP-Seq_EML_Mouse1.24534838
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22435981
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22179271
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.21584517
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20950415
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20334151
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.19827468
89* SCL_19346495_ChIP-Seq_HPC-7_Human1.19703325
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19459635
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19130528
92NCOR1_26117541_ChIP-Seq_K562_Human1.18852818
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18757535
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17473873
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16966040
96* FOXP1_21924763_ChIP-Seq_HESCs_Human1.15738162
97RARB_27405468_Chip-Seq_BRAIN_Mouse1.15725026
98STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15452932
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.15311680
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14813579
101BCOR_27268052_Chip-Seq_Bcells_Human1.14610877
102P68_20966046_ChIP-Seq_HELA_Human1.14560901
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14033073
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13891556
105* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11522896
106EZH2_22144423_ChIP-Seq_EOC_Human1.10888110
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.10774129
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10651509
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10393375
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10051598
111* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08531951
112* TFEB_21752829_ChIP-Seq_HELA_Human1.08096804
113LXR_22292898_ChIP-Seq_THP-1_Human1.07015362
114* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06603796
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06582118
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06582118
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06582118
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06404508
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06258525
120STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05801441
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04954524
122* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03472886
123KDM2B_26808549_Chip-Seq_DND41_Human1.03321360
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03015085
125* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02685105
126E2F1_21310950_ChIP-Seq_MCF-7_Human1.02155959
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01021059
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00291945
129* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00201804
130SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00164381
131* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99849278
132* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99675790
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.99675571
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98878499
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98308640
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98041081
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97971071
138PHF8_20622854_ChIP-Seq_HELA_Human0.97899873
139REST_18959480_ChIP-ChIP_MESCs_Mouse0.97661774
140BCL6_27268052_Chip-Seq_Bcells_Human0.96236083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.75499232
2MP0004859_abnormal_synaptic_plasticity3.70183171
3MP0003693_abnormal_embryo_hatching3.21009092
4MP0009278_abnormal_bone_marrow3.19656384
5MP0005451_abnormal_body_composition3.03208477
6MP0003111_abnormal_nucleus_morphology2.95981158
7MP0009333_abnormal_splenocyte_physiolog2.75433605
8MP0003436_decreased_susceptibility_to2.74104233
9MP0003806_abnormal_nucleotide_metabolis2.72135086
10MP0005058_abnormal_lysosome_morphology2.65751876
11MP0005423_abnormal_somatic_nervous2.63365167
12MP0004957_abnormal_blastocyst_morpholog2.63312426
13MP0006292_abnormal_olfactory_placode2.56965989
14MP0010094_abnormal_chromosome_stability2.54870514
15MP0001545_abnormal_hematopoietic_system2.35224138
16MP0005397_hematopoietic_system_phenotyp2.35224138
17MP0003077_abnormal_cell_cycle2.34970384
18MP0003635_abnormal_synaptic_transmissio2.33899467
19MP0009046_muscle_twitch2.19432304
20MP0008260_abnormal_autophagy2.18276778
21MP0003303_peritoneal_inflammation2.16580188
22MP0003123_paternal_imprinting2.11516638
23MP0001348_abnormal_lacrimal_gland2.10670067
24MP0008877_abnormal_DNA_methylation2.10613921
25MP0001835_abnormal_antigen_presentation1.96850752
26MP0008058_abnormal_DNA_repair1.94880941
27MP0003880_abnormal_central_pattern1.89579965
28MP0005000_abnormal_immune_tolerance1.89388259
29MP0005025_abnormal_response_to1.88697555
30MP0004185_abnormal_adipocyte_glucose1.87003762
31MP0002064_seizures1.84239435
32MP0000465_gastrointestinal_hemorrhage1.82670887
33MP0008057_abnormal_DNA_replication1.81381980
34MP0002148_abnormal_hypersensitivity_rea1.76198231
35MP0002063_abnormal_learning/memory/cond1.73911468
36MP0002420_abnormal_adaptive_immunity1.70907607
37MP0001819_abnormal_immune_cell1.69712078
38MP0001873_stomach_inflammation1.64666096
39MP0002419_abnormal_innate_immunity1.64306679
40MP0009840_abnormal_foam_cell1.63959963
41MP0001800_abnormal_humoral_immune1.62233054
42MP0005464_abnormal_platelet_physiology1.61741014
43MP0009745_abnormal_behavioral_response1.61437843
44MP0002723_abnormal_immune_serum1.60998917
45MP0003191_abnormal_cellular_cholesterol1.60487034
46MP0003283_abnormal_digestive_organ1.60189198
47MP0001853_heart_inflammation1.59719053
48MP0002452_abnormal_antigen_presenting1.59484170
49MP0002877_abnormal_melanocyte_morpholog1.59385376
50MP0002572_abnormal_emotion/affect_behav1.58823900
51MP0000716_abnormal_immune_system1.58676663
52MP0006036_abnormal_mitochondrial_physio1.57969464
53MP0005394_taste/olfaction_phenotype1.57168775
54MP0005499_abnormal_olfactory_system1.57168775
55MP0002429_abnormal_blood_cell1.56877797
56MP0008007_abnormal_cellular_replicative1.55443701
57MP0004142_abnormal_muscle_tone1.54936499
58MP0003787_abnormal_imprinting1.54665573
59MP0008569_lethality_at_weaning1.54354413
60MP0005671_abnormal_response_to1.52914364
61MP0004133_heterotaxia1.52541712
62MP0002019_abnormal_tumor_incidence1.51598848
63MP0000490_abnormal_crypts_of1.50027282
64MP0001730_embryonic_growth_arrest1.49001577
65MP0008932_abnormal_embryonic_tissue1.46711933
66MP0002272_abnormal_nervous_system1.43084501
67MP0000350_abnormal_cell_proliferation1.42715716
68MP0004270_analgesia1.42544799
69MP0002396_abnormal_hematopoietic_system1.39381304
70MP0003121_genomic_imprinting1.37317103
71MP0003122_maternal_imprinting1.34856486
72MP0004811_abnormal_neuron_physiology1.31642022
73MP0000858_altered_metastatic_potential1.29797007
74MP0002405_respiratory_system_inflammati1.29795598
75MP0004947_skin_inflammation1.28530726
76MP0002733_abnormal_thermal_nociception1.20511746
77MP0000955_abnormal_spinal_cord1.19651127
78MP0002080_prenatal_lethality1.19170468
79MP0001968_abnormal_touch/_nociception1.19059330
80MP0002822_catalepsy1.18177347
81MP0002254_reproductive_system_inflammat1.17595833
82MP0002132_abnormal_respiratory_system1.16636421
83MP0003119_abnormal_digestive_system1.15933807
84MP0000685_abnormal_immune_system1.14977208
85MP0001188_hyperpigmentation1.14877105
86MP0005076_abnormal_cell_differentiation1.14800150
87MP0001697_abnormal_embryo_size1.14622153
88MP0009785_altered_susceptibility_to1.13415376
89MP0002909_abnormal_adrenal_gland1.13391401
90MP0000313_abnormal_cell_death1.13380850
91MP0001986_abnormal_taste_sensitivity1.13163826
92MP0005387_immune_system_phenotype1.12079292
93MP0001790_abnormal_immune_system1.12079292
94MP0002734_abnormal_mechanical_nocicepti1.11101042
95MP0005380_embryogenesis_phenotype1.10028514
96MP0001672_abnormal_embryogenesis/_devel1.10028514
97MP0002184_abnormal_innervation1.09272600
98MP0002067_abnormal_sensory_capabilities1.08201978
99MP0001440_abnormal_grooming_behavior1.07460128
100MP0003786_premature_aging1.06351846
101MP0002557_abnormal_social/conspecific_i1.06099492
102MP0002084_abnormal_developmental_patter1.05998722
103MP0006035_abnormal_mitochondrial_morpho1.05668092
104MP0003890_abnormal_embryonic-extraembry1.05504328
105MP0002085_abnormal_embryonic_tissue1.04469492
106MP0005666_abnormal_adipose_tissue1.04336907
107MP0004808_abnormal_hematopoietic_stem1.04028441
108MP0001486_abnormal_startle_reflex1.03687704
109MP0000631_abnormal_neuroendocrine_gland1.02575405
110MP0001533_abnormal_skeleton_physiology1.01554666
111MP0001970_abnormal_pain_threshold1.01197105
112MP0001529_abnormal_vocalization1.01010308
113MP0005075_abnormal_melanosome_morpholog1.00943127
114MP0008469_abnormal_protein_level1.00708067
115MP0003861_abnormal_nervous_system1.00417175
116MP0004145_abnormal_muscle_electrophysio1.00263110
117MP0000703_abnormal_thymus_morphology1.00206388
118MP0001845_abnormal_inflammatory_respons0.99621335
119MP0002152_abnormal_brain_morphology0.99166297
120MP0002736_abnormal_nociception_after0.98849477
121MP0001293_anophthalmia0.97409000
122MP0005501_abnormal_skin_physiology0.97364242
123MP0003984_embryonic_growth_retardation0.97195050
124MP0010155_abnormal_intestine_physiology0.95795750
125MP0008995_early_reproductive_senescence0.95677715
126MP0004233_abnormal_muscle_weight0.95097709
127MP0004885_abnormal_endolymph0.94670430
128MP0008789_abnormal_olfactory_epithelium0.94135559
129MP0001485_abnormal_pinna_reflex0.93821033
130MP0002751_abnormal_autonomic_nervous0.93340486
131MP0003866_abnormal_defecation0.92942165
132MP0003656_abnormal_erythrocyte_physiolo0.92871476
133MP0002088_abnormal_embryonic_growth/wei0.92022025
134MP0010307_abnormal_tumor_latency0.91591137
135MP0001851_eye_inflammation0.91398064
136MP0003763_abnormal_thymus_physiology0.91088885
137MP0002882_abnormal_neuron_morphology0.90983759
138MP0008770_decreased_survivor_rate0.90474173
139MP0002066_abnormal_motor_capabilities/c0.90409450
140MP0006082_CNS_inflammation0.90223880
141MP0003172_abnormal_lysosome_physiology0.89355204
142MP0002089_abnormal_postnatal_growth/wei0.88640448
143MP0000778_abnormal_nervous_system0.87094493
144MP0005386_behavior/neurological_phenoty0.85877467
145MP0004924_abnormal_behavior0.85877467
146MP0005360_urolithiasis0.85456470
147MP0000358_abnormal_cell_content/0.84731726
148MP0002735_abnormal_chemical_nociception0.84652934
149MP0002398_abnormal_bone_marrow0.84144504
150MP0005375_adipose_tissue_phenotype0.83879102
151MP0004858_abnormal_nervous_system0.83690263
152MP0000678_abnormal_parathyroid_gland0.83566350
153MP0000003_abnormal_adipose_tissue0.82438382
154MP0005670_abnormal_white_adipose0.81377948
155MP0003300_gastrointestinal_ulcer0.81180500
156MP0009931_abnormal_skin_appearance0.80766895
157MP0003186_abnormal_redox_activity0.80489581
158MP0001849_ear_inflammation0.79904809
159MP0008872_abnormal_physiological_respon0.79690361
160MP0003137_abnormal_impulse_conducting0.78724921
161MP0002970_abnormal_white_adipose0.77521588
162MP0002210_abnormal_sex_determination0.77049144
163MP0000751_myopathy0.76314106
164MP0009763_increased_sensitivity_to0.75736555
165MP0000689_abnormal_spleen_morphology0.75323315
166MP0001501_abnormal_sleep_pattern0.75083318
167MP0002722_abnormal_immune_system0.74072957
168MP0005310_abnormal_salivary_gland0.73966262
169MP0000681_abnormal_thyroid_gland0.73892155
170MP0008873_increased_physiological_sensi0.73878327
171MP0001727_abnormal_embryo_implantation0.71915954
172MP0005621_abnormal_cell_physiology0.71611380
173MP0002796_impaired_skin_barrier0.70670604
174MP0001764_abnormal_homeostasis0.68972800

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.71046657
2Ependymoma (HP:0002888)4.00271172
3Ragged-red muscle fibers (HP:0003200)3.65390033
4Abnormality of the lower motor neuron (HP:0002366)3.62284678
5Increased muscle lipid content (HP:0009058)3.39293718
6Thrombocytosis (HP:0001894)3.35374759
7Medulloblastoma (HP:0002885)3.31916684
8Increased intramyocellular lipid droplets (HP:0012240)3.23682716
9Hypertensive crisis (HP:0100735)3.18878284
10Agammaglobulinemia (HP:0004432)3.17402918
11Panhypogammaglobulinemia (HP:0003139)3.11464889
12Obstructive lung disease (HP:0006536)3.00542084
13Chronic obstructive pulmonary disease (HP:0006510)3.00542084
14Abnormal number of erythroid precursors (HP:0012131)2.96011529
15Abnormality of cells of the erythroid lineage (HP:0012130)2.95118475
16Annular pancreas (HP:0001734)2.91030203
17Cellulitis (HP:0100658)2.88464255
18Recurrent viral infections (HP:0004429)2.86005081
19Granulocytopenia (HP:0001913)2.79264466
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.79221803
21Broad distal phalanx of finger (HP:0009836)2.78079950
22Birth length less than 3rd percentile (HP:0003561)2.72983937
23Unsteady gait (HP:0002317)2.72394976
24Recurrent fungal infections (HP:0002841)2.70446513
25Spastic paraparesis (HP:0002313)2.69457511
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.68135875
27Amyotrophic lateral sclerosis (HP:0007354)2.67261691
28Increased cerebral lipofuscin (HP:0011813)2.62807832
29CNS hypomyelination (HP:0003429)2.62071252
30Abnormality of the astrocytes (HP:0100707)2.61885366
31Astrocytoma (HP:0009592)2.61885366
32Increased serum ferritin (HP:0003281)2.61037587
33Mediastinal lymphadenopathy (HP:0100721)2.59109275
34Patellar aplasia (HP:0006443)2.56712236
35Petechiae (HP:0000967)2.54187237
36Increased IgE level (HP:0003212)2.48949937
37Basal cell carcinoma (HP:0002671)2.48703924
38Visual hallucinations (HP:0002367)2.48268507
39Aplastic anemia (HP:0001915)2.47495521
40Seborrheic dermatitis (HP:0001051)2.46296022
41Colitis (HP:0002583)2.46018283
42Premature ovarian failure (HP:0008209)2.45433151
43Pointed chin (HP:0000307)2.45074103
44Eczematoid dermatitis (HP:0000976)2.44729777
45Multiple enchondromatosis (HP:0005701)2.42823569
46B lymphocytopenia (HP:0010976)2.42275775
47Breast hypoplasia (HP:0003187)2.42031077
48Focal motor seizures (HP:0011153)2.41765565
49Acute lymphatic leukemia (HP:0006721)2.41761859
50Reticulocytopenia (HP:0001896)2.39527198
51Elevated erythrocyte sedimentation rate (HP:0003565)2.39399565
52Hepatosplenomegaly (HP:0001433)2.37506303
53Atonic seizures (HP:0010819)2.36782447
54Hepatocellular necrosis (HP:0001404)2.36056633
55Aplasia/Hypoplasia of the patella (HP:0006498)2.35611162
56Colon cancer (HP:0003003)2.32935829
57Aplasia/Hypoplasia of the thymus (HP:0010515)2.32157469
58Thoracic kyphosis (HP:0002942)2.32011460
59Atrophy/Degeneration involving motor neurons (HP:0007373)2.30436293
60Loss of speech (HP:0002371)2.28663540
61Abnormal gallbladder physiology (HP:0012438)2.25597416
62Cholecystitis (HP:0001082)2.25597416
63Meningitis (HP:0001287)2.25425277
64Myokymia (HP:0002411)2.24412977
65Focal seizures (HP:0007359)2.23714915
66Abnormality of the labia minora (HP:0012880)2.22574464
67Neoplasm of the oral cavity (HP:0100649)2.21492008
68Abnormality of B cell number (HP:0010975)2.20828270
69Recurrent abscess formation (HP:0002722)2.20584571
70Delusions (HP:0000746)2.16498436
71Glioma (HP:0009733)2.14537767
72Epileptic encephalopathy (HP:0200134)2.14429189
73Chronic mucocutaneous candidiasis (HP:0002728)2.14153443
74Recurrent cutaneous fungal infections (HP:0011370)2.14153443
75Rough bone trabeculation (HP:0100670)2.13679810
76Stomatitis (HP:0010280)2.13590326
77Gastrointestinal inflammation (HP:0004386)2.12088608
78Abnormality of iron homeostasis (HP:0011031)2.11518493
79Abnormality of the columella (HP:0009929)2.10785182
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08489417
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07797030
82Dicarboxylic aciduria (HP:0003215)2.07797030
83Pancytopenia (HP:0001876)2.07645863
84Supernumerary spleens (HP:0009799)2.06796795
85Abnormality of glycolipid metabolism (HP:0010969)2.06741218
86Abnormality of liposaccharide metabolism (HP:0010968)2.06741218
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.06741218
88Severe combined immunodeficiency (HP:0004430)2.06661143
89Prominent nose (HP:0000448)2.06636110
90Centrally nucleated skeletal muscle fibers (HP:0003687)2.06045965
91Impaired smooth pursuit (HP:0007772)2.03742472
92Agnosia (HP:0010524)2.02672592
93Poor eye contact (HP:0000817)2.00974751
94Abnormality of reticulocytes (HP:0004312)2.00712126
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00097678
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00097678
97Recurrent bacterial skin infections (HP:0005406)1.99418547
98Combined immunodeficiency (HP:0005387)1.98573019
99Type I transferrin isoform profile (HP:0003642)1.98511590
100Hepatic necrosis (HP:0002605)1.97594550
101Reticulocytosis (HP:0001923)1.96875348
102Trismus (HP:0000211)1.96184314
103Abnormality of ocular smooth pursuit (HP:0000617)1.95981674
104Neuroblastoma (HP:0003006)1.95632084
105Primitive neuroectodermal tumor (HP:0030065)1.95632084
106Neuroblastic tumors (HP:0004376)1.95632084
107Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.95632084
108Pallor (HP:0000980)1.95104224
109Broad-based gait (HP:0002136)1.94856970
110Abnormal mitochondria in muscle tissue (HP:0008316)1.93371411
111Exercise intolerance (HP:0003546)1.92584523
112Abnormality of the thoracic spine (HP:0100711)1.92104017
113Abnormality of T cell physiology (HP:0011840)1.91776297
114Macrocytic anemia (HP:0001972)1.91470905
115Hyperacusis (HP:0010780)1.91287021
116Rib fusion (HP:0000902)1.91269205
117Abnormality of the ileum (HP:0001549)1.91263578
118Horizontal nystagmus (HP:0000666)1.90124419
119Meckel diverticulum (HP:0002245)1.90116429
120Emotional lability (HP:0000712)1.89334088
121Recurrent skin infections (HP:0001581)1.89327759
122Achilles tendon contracture (HP:0001771)1.88967841
123Respiratory difficulties (HP:0002880)1.88759850
124Absent thumb (HP:0009777)1.88117940
125Neoplasm of striated muscle (HP:0009728)1.88041126
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.87680739
127Abnormal neuron morphology (HP:0012757)1.87471073
128Abnormality of the motor neurons (HP:0002450)1.87471073
129Progressive muscle weakness (HP:0003323)1.86624677
130Pustule (HP:0200039)1.85915961
131Opisthotonus (HP:0002179)1.85027178
132Malignant neoplasm of the central nervous system (HP:0100836)1.84857691
133Degeneration of anterior horn cells (HP:0002398)1.84615366
134Abnormality of the anterior horn cell (HP:0006802)1.84615366
135Progressive cerebellar ataxia (HP:0002073)1.84549717
136Carpal bone hypoplasia (HP:0001498)1.84475896
137Purpura (HP:0000979)1.84186351
138Hypergammaglobulinemia (HP:0010702)1.83819207
139Asplenia (HP:0001746)1.83656312
140Truncus arteriosus (HP:0001660)1.83484661
141Autoimmune thrombocytopenia (HP:0001973)1.82495775
142Impulsivity (HP:0100710)1.82436515
143Horseshoe kidney (HP:0000085)1.80332777
144Mitochondrial inheritance (HP:0001427)1.80039873
145Progressive external ophthalmoplegia (HP:0000590)1.80036844
146Vertebral compression fractures (HP:0002953)1.79911540
147Abnormal protein N-linked glycosylation (HP:0012347)1.79902122
148Abnormal protein glycosylation (HP:0012346)1.79902122
149Abnormal glycosylation (HP:0012345)1.79902122
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79902122
151Increased IgM level (HP:0003496)1.79632368
152Inflammation of the large intestine (HP:0002037)1.79104070
153Fatigue (HP:0012378)1.78968968
154Progressive microcephaly (HP:0000253)1.78485875
155Febrile seizures (HP:0002373)1.77782726
156Impaired social interactions (HP:0000735)1.76574972
157Abnormal social behavior (HP:0012433)1.76574972
158Personality changes (HP:0000751)1.76458333
159Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76314839
160Insomnia (HP:0100785)1.76242133
161Secondary amenorrhea (HP:0000869)1.72457251
162Myelodysplasia (HP:0002863)1.71501303
163Ankle clonus (HP:0011448)1.70512349
164Microvesicular hepatic steatosis (HP:0001414)1.69580239
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.68417549
166Shoulder girdle muscle weakness (HP:0003547)1.68256339
167Abnormality of the aortic arch (HP:0012303)1.67626292
168Stereotypic behavior (HP:0000733)1.66512500
169Neoplasm of the heart (HP:0100544)1.66445735
170Abnormal number of incisors (HP:0011064)1.66421645
171Selective tooth agenesis (HP:0001592)1.65788371
172Rhabdomyosarcoma (HP:0002859)1.64907786
173Testicular atrophy (HP:0000029)1.62764626
174Microretrognathia (HP:0000308)1.62694316
175Dysphonia (HP:0001618)1.61755547
176Aplasia/Hypoplasia of the uvula (HP:0010293)1.61381449
177Attention deficit hyperactivity disorder (HP:0007018)1.60217807
178Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60198023
179Obstructive sleep apnea (HP:0002870)1.58998737
180Hemiplegia (HP:0002301)1.58916905
181Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58800841
182Missing ribs (HP:0000921)1.58609140
183Renal duplication (HP:0000075)1.58391171
184Diplopia (HP:0000651)1.58177617
185Abnormality of binocular vision (HP:0011514)1.58177617
186Abnormality of the preputium (HP:0100587)1.58168886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK22.87423256
2KDR2.86849801
3SMG12.83894043
4ERN12.83796262
5BUB12.83584068
6EEF2K2.83553695
7IRAK32.74677127
8TSSK62.70226004
9PIM22.53598623
10TESK22.50971104
11BCKDK2.40785700
12AKT32.38315726
13TLK12.23538470
14WEE12.18115499
15PNCK2.16215518
16CDK192.15835334
17TRIB32.08998241
18ARAF1.94509581
19TAOK21.91279355
20TYRO31.86257750
21MAP2K31.86227724
22DAPK11.84313996
23MAP4K11.83208625
24MAP3K91.83077110
25NTRK31.81354620
26MAP3K101.78953075
27NEK21.74720356
28TESK11.73316130
29BRSK11.72908825
30PLK41.62916856
31NEK11.62194408
32ALK1.60636545
33EPHA41.45283993
34MARK11.41071625
35SIK21.39982701
36MINK11.39393759
37MAP3K111.36580237
38TBK11.36123531
39CDC71.35907558
40UHMK11.34178265
41SRPK11.33434191
42GRK61.26774434
43TTK1.21713154
44STK161.21454879
45CAMKK21.18104517
46PLK11.15305780
47RPS6KB21.12267149
48VRK11.12250228
49DYRK31.09131791
50PASK1.08685556
51CAMKK11.07892627
52NTRK21.04446734
53ATR1.04221109
54MAP3K141.02621946
55CDK121.01829534
56CDK71.01685432
57SIK10.99185581
58BRAF0.98693002
59MAPK110.97926292
60TAOK30.97143643
61MATK0.96864824
62CAMK40.96512450
63IRAK40.95243026
64RPS6KA50.95167478
65MKNK20.94626651
66IKBKB0.92960126
67ABL20.92382778
68AURKA0.91676935
69BRSK20.91329909
70MAP3K10.90895280
71TYK20.88776304
72CDK20.88485710
73PIM10.85488862
74MAPKAPK30.85091469
75EIF2AK10.84417478
76MAP3K130.83955150
77BTK0.83939668
78PRPF4B0.82843458
79TAOK10.82715314
80CHEK10.82425920
81MAP2K20.80284432
82CCNB10.79495804
83RIPK40.79476839
84PAK60.79354202
85TNIK0.79161744
86RPS6KA40.76449332
87ICK0.76078027
88CDC42BPA0.74436939
89PAK40.72295001
90MKNK10.71503586
91PLK30.70580206
92MAPK130.67629146
93CHEK20.67611598
94LRRK20.66963289
95BRD40.65953281
96PLK20.65913723
97FES0.64846325
98CSNK1E0.64563981
99MAP3K30.64255686
100PRKD20.64190669
101AURKB0.63878335
102CDK11A0.63516215
103SYK0.63203797
104PKN20.61499900
105ITK0.60180546
106RPS6KC10.60173194
107RPS6KL10.60173194
108PRKCG0.59758886
109AKT20.59129442
110ZAK0.58946079
111SCYL20.58493704
112CDK150.57840675
113IKBKE0.57605546
114NME10.56777073
115MAP2K60.56735927
116TXK0.55554460
117PRKCI0.55455849
118CDK180.54760875
119CDK50.54740571
120CDK10.54595680
121KIT0.54308541
122CDK80.54258287
123CAMK10.54103289
124CSNK2A20.53486143
125CDK90.53072763
126PRKCH0.52714218
127TNK20.52460552
128MTOR0.52299477
129PRKD30.51578409
130JAK30.50645403
131CSF1R0.50089379
132RAF10.49838686
133WNK30.48979295
134PAK10.48225877
135HCK0.47928815
136CDK140.47709227
137CDK40.45962920
138MAP3K80.45933451
139ZAP700.45520773
140RPS6KA60.45486123
141STK100.44764362
142LYN0.44718021
143MAPK120.44688586
144RPS6KA20.44201581
145PRKDC0.43877666
146LCK0.43801758
147DYRK1A0.43748718
148KSR20.43167339
149NME20.42899896
150IRAK20.42492509
151FLT30.42463163
152CDK60.41436901
153BLK0.41148856
154RPS6KA10.39767030
155BMX0.37622077
156HIPK20.37381528
157PDK20.35881826

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.67590167
2Spliceosome_Homo sapiens_hsa030403.41094771
3Mismatch repair_Homo sapiens_hsa034303.39675234
4Ribosome_Homo sapiens_hsa030103.37330766
5RNA polymerase_Homo sapiens_hsa030202.77055936
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71268991
7Base excision repair_Homo sapiens_hsa034102.49271283
8RNA transport_Homo sapiens_hsa030132.48474364
9Other glycan degradation_Homo sapiens_hsa005112.26324602
10Nicotine addiction_Homo sapiens_hsa050331.97718793
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93950406
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.92804449
13Pyrimidine metabolism_Homo sapiens_hsa002401.74781591
14Nucleotide excision repair_Homo sapiens_hsa034201.74222979
15Homologous recombination_Homo sapiens_hsa034401.73709541
16mRNA surveillance pathway_Homo sapiens_hsa030151.72961808
17Synaptic vesicle cycle_Homo sapiens_hsa047211.70998415
18Proteasome_Homo sapiens_hsa030501.69498057
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.69183895
20Long-term potentiation_Homo sapiens_hsa047201.51178080
21Pentose phosphate pathway_Homo sapiens_hsa000301.45930963
22Cell cycle_Homo sapiens_hsa041101.40584966
23Systemic lupus erythematosus_Homo sapiens_hsa053221.39720299
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36972664
25Oocyte meiosis_Homo sapiens_hsa041141.36191348
26RNA degradation_Homo sapiens_hsa030181.34476566
27Fanconi anemia pathway_Homo sapiens_hsa034601.30973307
28Asthma_Homo sapiens_hsa053101.27908137
29Amphetamine addiction_Homo sapiens_hsa050311.19990650
30Circadian entrainment_Homo sapiens_hsa047131.14911662
31Allograft rejection_Homo sapiens_hsa053301.13891587
32GABAergic synapse_Homo sapiens_hsa047271.13711301
33Notch signaling pathway_Homo sapiens_hsa043301.13640877
34Leishmaniasis_Homo sapiens_hsa051401.13610816
35Olfactory transduction_Homo sapiens_hsa047401.13342757
36Glutamatergic synapse_Homo sapiens_hsa047241.10270228
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10129915
38One carbon pool by folate_Homo sapiens_hsa006701.09589766
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09320181
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08675092
41Antigen processing and presentation_Homo sapiens_hsa046121.07786731
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.06020659
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05882327
44Autoimmune thyroid disease_Homo sapiens_hsa053201.05504292
45Bladder cancer_Homo sapiens_hsa052191.04237100
46Purine metabolism_Homo sapiens_hsa002301.02159340
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00322457
48Shigellosis_Homo sapiens_hsa051310.99116780
49Carbon metabolism_Homo sapiens_hsa012000.98255173
50Dopaminergic synapse_Homo sapiens_hsa047280.97813467
51Primary immunodeficiency_Homo sapiens_hsa053400.97599666
52Morphine addiction_Homo sapiens_hsa050320.96914658
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.95208798
54Graft-versus-host disease_Homo sapiens_hsa053320.94874210
55Epstein-Barr virus infection_Homo sapiens_hsa051690.94559318
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92683757
57Viral carcinogenesis_Homo sapiens_hsa052030.92490114
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91921708
59Non-homologous end-joining_Homo sapiens_hsa034500.89809331
60Parkinsons disease_Homo sapiens_hsa050120.88656299
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88066922
62Influenza A_Homo sapiens_hsa051640.85688411
63mTOR signaling pathway_Homo sapiens_hsa041500.85215206
64Chronic myeloid leukemia_Homo sapiens_hsa052200.82670791
65Viral myocarditis_Homo sapiens_hsa054160.81601258
66Osteoclast differentiation_Homo sapiens_hsa043800.81280674
67Taste transduction_Homo sapiens_hsa047420.80767175
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80571737
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80047658
70Galactose metabolism_Homo sapiens_hsa000520.79831607
71Basal transcription factors_Homo sapiens_hsa030220.77834199
72Apoptosis_Homo sapiens_hsa042100.77205388
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75353998
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74742398
75Hematopoietic cell lineage_Homo sapiens_hsa046400.74613198
76Insulin secretion_Homo sapiens_hsa049110.74055903
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.73728998
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72961275
79Alcoholism_Homo sapiens_hsa050340.72652841
80Long-term depression_Homo sapiens_hsa047300.71990854
81Folate biosynthesis_Homo sapiens_hsa007900.71656569
82Hepatitis B_Homo sapiens_hsa051610.70796117
83Lysosome_Homo sapiens_hsa041420.70582573
84Oxidative phosphorylation_Homo sapiens_hsa001900.70541886
85Biosynthesis of amino acids_Homo sapiens_hsa012300.68468149
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67837002
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67728103
88Pancreatic cancer_Homo sapiens_hsa052120.66676230
89Colorectal cancer_Homo sapiens_hsa052100.65497912
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64604099
91Regulation of autophagy_Homo sapiens_hsa041400.64310310
92Fatty acid elongation_Homo sapiens_hsa000620.63692036
93Sulfur relay system_Homo sapiens_hsa041220.63628221
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61830054
95Basal cell carcinoma_Homo sapiens_hsa052170.61121206
96Measles_Homo sapiens_hsa051620.60829481
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.60607795
98Thyroid cancer_Homo sapiens_hsa052160.59732363
99Calcium signaling pathway_Homo sapiens_hsa040200.58544972
100Tuberculosis_Homo sapiens_hsa051520.58121424
101N-Glycan biosynthesis_Homo sapiens_hsa005100.57716159
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.57607982
103Gastric acid secretion_Homo sapiens_hsa049710.57437602
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56942673
105Legionellosis_Homo sapiens_hsa051340.56884452
106Cardiac muscle contraction_Homo sapiens_hsa042600.56725565
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56497283
108Oxytocin signaling pathway_Homo sapiens_hsa049210.55736593
109Cocaine addiction_Homo sapiens_hsa050300.55564845
110p53 signaling pathway_Homo sapiens_hsa041150.55397379
111Gap junction_Homo sapiens_hsa045400.55108857
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54904528
113Cholinergic synapse_Homo sapiens_hsa047250.54159594
114Melanogenesis_Homo sapiens_hsa049160.53964512
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53929062
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53687119
117Salmonella infection_Homo sapiens_hsa051320.53507474
118B cell receptor signaling pathway_Homo sapiens_hsa046620.52714983
119Toxoplasmosis_Homo sapiens_hsa051450.52704859
120Wnt signaling pathway_Homo sapiens_hsa043100.51519837
121Fructose and mannose metabolism_Homo sapiens_hsa000510.51275985
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.51274147
123Salivary secretion_Homo sapiens_hsa049700.50409483
124Phototransduction_Homo sapiens_hsa047440.50073798
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49384298
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49312426
127Rheumatoid arthritis_Homo sapiens_hsa053230.48725851
128T cell receptor signaling pathway_Homo sapiens_hsa046600.48504379
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48251896
130Type I diabetes mellitus_Homo sapiens_hsa049400.47964490
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47920518
132Circadian rhythm_Homo sapiens_hsa047100.47638004
133Estrogen signaling pathway_Homo sapiens_hsa049150.45129066
134Acute myeloid leukemia_Homo sapiens_hsa052210.45126907
135Hedgehog signaling pathway_Homo sapiens_hsa043400.45008742
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42785062
137Huntingtons disease_Homo sapiens_hsa050160.41996820
138HTLV-I infection_Homo sapiens_hsa051660.41871844
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.41258007
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40788575
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39863088
142GnRH signaling pathway_Homo sapiens_hsa049120.39049158
143Serotonergic synapse_Homo sapiens_hsa047260.39015858
144Non-small cell lung cancer_Homo sapiens_hsa052230.38959169
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38011122
146Pertussis_Homo sapiens_hsa051330.37333811
147TNF signaling pathway_Homo sapiens_hsa046680.36904354
148Herpes simplex infection_Homo sapiens_hsa051680.36767358
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36393085
150Inositol phosphate metabolism_Homo sapiens_hsa005620.36089921
151Phenylalanine metabolism_Homo sapiens_hsa003600.34996265
152MAPK signaling pathway_Homo sapiens_hsa040100.34661257
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34407248
154Glioma_Homo sapiens_hsa052140.33627215
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.33115401

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »