DUSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.58082772
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.58082772
3sleep (GO:0030431)4.74937220
4regulation of germinal center formation (GO:0002634)4.55376930
5regulation of B cell receptor signaling pathway (GO:0050855)4.48491886
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.35397842
7cellular response to interleukin-15 (GO:0071350)4.33029959
8microglial cell activation (GO:0001774)4.24780037
9response to interleukin-15 (GO:0070672)3.92061825
10positive regulation of gamma-delta T cell activation (GO:0046645)3.91852867
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.89966575
12regulation of gamma-delta T cell differentiation (GO:0045586)3.89764252
13negative regulation of interleukin-1 beta production (GO:0032691)3.81882451
14definitive hemopoiesis (GO:0060216)3.81593262
15regulation of gamma-delta T cell activation (GO:0046643)3.79179232
16regulation of T cell mediated cytotoxicity (GO:0001914)3.67622195
17response to muramyl dipeptide (GO:0032495)3.65091689
18negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.58276758
19positive regulation of T cell differentiation in thymus (GO:0033089)3.57373901
20negative thymic T cell selection (GO:0045060)3.49800445
21negative regulation of interleukin-1 production (GO:0032692)3.49729038
22dendritic cell chemotaxis (GO:0002407)3.45344611
23lymph vessel development (GO:0001945)3.43593371
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41463572
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.41463572
26modulation by symbiont of host immune response (GO:0052553)3.41463572
27positive regulation by symbiont of host defense response (GO:0052509)3.41463572
28modulation by symbiont of host defense response (GO:0052031)3.41463572
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41463572
30negative T cell selection (GO:0043383)3.39761001
31response to laminar fluid shear stress (GO:0034616)3.37965624
32negative regulation of innate immune response (GO:0045824)3.37592683
33positive regulation of T cell mediated cytotoxicity (GO:0001916)3.36307952
34nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.35422094
35negative regulation of bone resorption (GO:0045779)3.33708406
36positive regulation of cholesterol efflux (GO:0010875)3.33546056
37regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.32077621
38positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.32077621
39response to gravity (GO:0009629)3.30730102
40positive thymic T cell selection (GO:0045059)3.27008058
41negative regulation of T cell mediated immunity (GO:0002710)3.26805724
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.24309732
43positive regulation of osteoclast differentiation (GO:0045672)3.23117913
44positive regulation of T cell cytokine production (GO:0002726)3.22706759
45G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.19928696
46negative regulation of lipid storage (GO:0010888)3.16958709
47regulation of memory T cell differentiation (GO:0043380)3.16198080
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11503745
49mast cell activation (GO:0045576)3.07747318
50positive regulation of defense response to virus by host (GO:0002230)3.05040312
51lymph node development (GO:0048535)3.03122803
52positive regulation of cholesterol transport (GO:0032376)3.02982416
53positive regulation of sterol transport (GO:0032373)3.02982416
54cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)3.02099185
55regulation of regulatory T cell differentiation (GO:0045589)3.01875522
56dendritic cell migration (GO:0036336)3.01522441
57regulation of cellular extravasation (GO:0002691)3.00686185
58positive regulation of prostaglandin secretion (GO:0032308)2.98252446
59macrophage activation (GO:0042116)2.97605623
60cellular extravasation (GO:0045123)2.97139912
61regulation of chronic inflammatory response (GO:0002676)2.96708379
62neutrophil activation involved in immune response (GO:0002283)2.95897821
63regulation of T cell mediated immunity (GO:0002709)2.95797358
64regulation of leukocyte mediated cytotoxicity (GO:0001910)2.95547996
65negative regulation of protein autophosphorylation (GO:0031953)2.95271603
66positive regulation of heat generation (GO:0031652)2.94036552
67endothelium development (GO:0003158)2.94006233
68negative regulation of leukocyte mediated immunity (GO:0002704)2.93926462
69regulation of monocyte differentiation (GO:0045655)2.93873985
70tumor necrosis factor-mediated signaling pathway (GO:0033209)2.93753804
71antigen processing and presentation via MHC class Ib (GO:0002475)2.93159848
72positive regulation of T cell mediated immunity (GO:0002711)2.88577736
73response to progesterone (GO:0032570)2.88488942
74positive regulation of T-helper 1 type immune response (GO:0002827)2.88419232
75cellular response to exogenous dsRNA (GO:0071360)2.87742837
76regulation of defense response to virus by host (GO:0050691)2.86886191
77interleukin-1-mediated signaling pathway (GO:0070498)2.86808123
78regulation of cell proliferation involved in kidney development (GO:1901722)2.86801351
79germ cell migration (GO:0008354)2.85850325
80regulation of alpha-beta T cell proliferation (GO:0046640)2.84531407
81negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.84278979
82blood vessel maturation (GO:0001955)2.82142162
83alpha-beta T cell differentiation (GO:0046632)2.81185318
84RNA destabilization (GO:0050779)2.79940036
85positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.79217265
86regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.79217265
87interferon-gamma production (GO:0032609)2.78904520
88negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.76746091
89regulation of T cell receptor signaling pathway (GO:0050856)2.76609752
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76509416
91regulation of cell killing (GO:0031341)2.76059518
92CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.75610422
93regulation of T-helper 1 type immune response (GO:0002825)2.74084000
94regulation of interferon-beta biosynthetic process (GO:0045357)2.74072238
95nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.71954890
96negative regulation of T cell apoptotic process (GO:0070233)2.68519308
97positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66849915
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66828017
99vascular endothelial growth factor signaling pathway (GO:0038084)2.66213281
100positive regulation of mRNA catabolic process (GO:0061014)2.65926492
101antigen processing and presentation of endogenous antigen (GO:0019883)2.65159035
102macrophage activation involved in immune response (GO:0002281)2.63715654
103negative regulation of granulocyte differentiation (GO:0030853)2.62235353
104regulation of T cell cytokine production (GO:0002724)2.61814870
105negative regulation of bone remodeling (GO:0046851)2.61391765
106surfactant homeostasis (GO:0043129)2.59981198
107alpha-beta T cell activation (GO:0046631)2.59968531
108B cell homeostasis (GO:0001782)2.58498113
109positive regulation of T cell differentiation (GO:0045582)2.57612255
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52711114
111antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52711114
112positive regulation of cellular amide metabolic process (GO:0034250)2.52189142
113regulation of interleukin-12 biosynthetic process (GO:0045075)2.51799362
114CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.49450222
115T-helper cell differentiation (GO:0042093)2.49450222
116monocyte chemotaxis (GO:0002548)2.47905803
117lymphangiogenesis (GO:0001946)2.46960634
118cellular response to fluid shear stress (GO:0071498)2.46555345
119germinal center formation (GO:0002467)2.45682024
120tolerance induction (GO:0002507)2.45446503
121neutrophil activation (GO:0042119)2.43201391
122radial glial cell differentiation (GO:0060019)2.42308115
123regulation of interleukin-8 biosynthetic process (GO:0045414)2.42064964
124purinergic nucleotide receptor signaling pathway (GO:0035590)2.40825526
125response to fluid shear stress (GO:0034405)2.39105119
126positive regulation of antigen processing and presentation (GO:0002579)2.38533184
127T-helper 1 type immune response (GO:0042088)2.38169662
128positive regulation of chemokine secretion (GO:0090197)2.38159858
129response to peptidoglycan (GO:0032494)2.37661367
130cellular response to antibiotic (GO:0071236)2.37656863
131hemidesmosome assembly (GO:0031581)2.37045272
132response to host immune response (GO:0052572)2.36223610
133response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.36223610
134lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36220319
135myeloid dendritic cell activation (GO:0001773)2.35108161
136atrioventricular valve morphogenesis (GO:0003181)2.34515692
137SMAD protein signal transduction (GO:0060395)2.34414655
138positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.33772526
139immunoglobulin mediated immune response (GO:0016064)2.32711563
140wound healing, spreading of cells (GO:0044319)2.32476871
141mRNA transcription from RNA polymerase II promoter (GO:0042789)2.32212499
142monocyte differentiation (GO:0030224)2.30775013
143Notch receptor processing (GO:0007220)2.29972632
144myeloid dendritic cell differentiation (GO:0043011)2.28761480
145myeloid leukocyte activation (GO:0002274)2.26254783
146regulation of mRNA catabolic process (GO:0061013)2.23616275
147negative regulation of inclusion body assembly (GO:0090084)2.23610417
148negative regulation of interleukin-8 production (GO:0032717)2.22544143
149regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.22151119
150myeloid cell activation involved in immune response (GO:0002275)2.21637167
151granulocyte activation (GO:0036230)2.21332566
152positive regulation of astrocyte differentiation (GO:0048711)2.19446020
153mature B cell differentiation involved in immune response (GO:0002313)2.18871612
154response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.18707174
155response to host (GO:0075136)2.18707174
156response to host defenses (GO:0052200)2.18707174
157regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.18443133
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.18232153
159regulation of antigen processing and presentation (GO:0002577)2.17021732
160wound healing, spreading of epidermal cells (GO:0035313)2.16516338
161positive regulation of toll-like receptor signaling pathway (GO:0034123)2.16306972
162negative regulation of systemic arterial blood pressure (GO:0003085)2.16084077
163regulation of dendritic cell antigen processing and presentation (GO:0002604)2.16006446
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.15994443
165cellular response to calcium ion (GO:0071277)2.15926924
166G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.15827621
167gland morphogenesis (GO:0022612)2.13565898
168alpha-beta T cell differentiation involved in immune response (GO:0002293)2.12225868
169alpha-beta T cell activation involved in immune response (GO:0002287)2.12225868
170T cell differentiation involved in immune response (GO:0002292)2.12225868
171cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.11674087
172negative regulation of interleukin-6 production (GO:0032715)2.11655587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.89803937
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.87605074
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.38742224
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.70070333
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.11218214
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.00756216
7SCL_19346495_ChIP-Seq_HPC-7_Human2.75168954
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.47674550
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41243080
10RUNX_20019798_ChIP-Seq_JUKART_Human2.36022017
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31847597
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.28683426
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.26605454
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.24381513
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.16446205
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.10363708
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09088374
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09088374
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09088374
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.06762787
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05583893
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02504205
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.98108381
24GATA3_27048872_Chip-Seq_THYMUS_Human1.96870266
25* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93093981
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92336515
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90027879
28* GATA3_26560356_Chip-Seq_TH2_Human1.87583727
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80575639
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74010748
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.72209003
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71636515
33UTX_26944678_Chip-Seq_JUKART_Human1.71616993
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.64556323
35VDR_24787735_ChIP-Seq_THP-1_Human1.61999484
36* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59196508
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58289963
38* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56989587
39* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.56534204
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55386296
41* SPI1_23547873_ChIP-Seq_NB4_Human1.55073994
42* CJUN_26792858_Chip-Seq_BT549_Human1.52744048
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52054068
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.49417191
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48483768
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48018573
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38863750
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38598022
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38262356
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37976081
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37095995
52* CLOCK_20551151_ChIP-Seq_293T_Human1.33953590
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.32436646
54* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31699078
55GATA1_19941826_ChIP-Seq_K562_Human1.31132100
56SOX2_20726797_ChIP-Seq_SW620_Human1.28074848
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26852578
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26852578
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26767113
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26017670
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24034458
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23046508
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22904792
64VDR_24763502_ChIP-Seq_THP-1_Human1.21584969
65GATA1_22025678_ChIP-Seq_K562_Human1.20230182
66* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16957794
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14717387
68* FOXO3_23340844_ChIP-Seq_DLD1_Human1.13359852
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13255170
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12808741
71MAF_26560356_Chip-Seq_TH2_Human1.11439250
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10242844
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09994618
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09218056
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09010538
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08862119
77AHR_22903824_ChIP-Seq_MCF-7_Human1.08354643
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07819142
79TP53_18474530_ChIP-ChIP_U2OS_Human1.06466823
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03472543
81MYB_26560356_Chip-Seq_TH2_Human1.03374185
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03303200
83* MAF_26560356_Chip-Seq_TH1_Human1.03244028
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03185972
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03007506
86GATA2_19941826_ChIP-Seq_K562_Human1.02240106
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.00358206
88STAT1_20625510_ChIP-Seq_HELA_Human0.98842214
89* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98195180
90* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97993306
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97959105
92P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97672930
93* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96697988
94TCF7_22412390_ChIP-Seq_EML_Mouse0.96166770
95* BCL6_27268052_Chip-Seq_Bcells_Human0.95310192
96* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94557523
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93009644
98* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92798326
99* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92798326
100TP53_16413492_ChIP-PET_HCT116_Human0.90871128
101* ELK3_25401928_ChIP-Seq_HUVEC_Human0.90022782
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89715470
103* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89498193
104VDR_21846776_ChIP-Seq_THP-1_Human0.89438171
105MYB_26560356_Chip-Seq_TH1_Human0.89027951
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88504776
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88255010
108PU_27001747_Chip-Seq_BMDM_Mouse0.88216072
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.87086335
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87021848
111* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86072707
112* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86031132
113* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85842912
114SMRT_27268052_Chip-Seq_Bcells_Human0.85716144
115* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84270914
116ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83090224
117* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82644523
118* P300_27268052_Chip-Seq_Bcells_Human0.82346635
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82321898
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81531376
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.81340854
122SPI1_23127762_ChIP-Seq_K562_Human0.80932862
123* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80804427
124* RUNX1_22412390_ChIP-Seq_EML_Mouse0.80465344
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80224262
126SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79183443
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79063164
128AR_21572438_ChIP-Seq_LNCaP_Human0.77774547
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.77615013
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77475236
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.77363730
132* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77362546
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77341766
134KDM2B_26808549_Chip-Seq_DND41_Human0.76748690
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76395453
136* LXR_22158963_ChIP-Seq_LIVER_Mouse0.75939686
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75602772
138* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.75447852
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75025066
140MYC_22102868_ChIP-Seq_BL_Human0.72760085
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70812658
142* BCOR_27268052_Chip-Seq_Bcells_Human0.70550442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.31039790
2* MP0003724_increased_susceptibility_to2.84717471
3MP0010368_abnormal_lymphatic_system2.72706979
4MP0001879_abnormal_lymphatic_vessel2.53572649
5MP0001835_abnormal_antigen_presentation2.50925424
6MP0009278_abnormal_bone_marrow2.45513955
7MP0001851_eye_inflammation2.41153942
8MP0002009_preneoplasia2.31637615
9MP0003436_decreased_susceptibility_to2.31167647
10MP0002148_abnormal_hypersensitivity_rea2.30310951
11MP0003303_peritoneal_inflammation2.22328453
12* MP0002419_abnormal_innate_immunity2.17650754
13MP0001790_abnormal_immune_system2.09269917
14MP0005387_immune_system_phenotype2.09269917
15* MP0003828_pulmonary_edema2.05553871
16* MP0005000_abnormal_immune_tolerance2.03812378
17MP0001853_heart_inflammation2.02066822
18MP0004381_abnormal_hair_follicle2.01349559
19MP0000383_abnormal_hair_follicle1.93255276
20MP0009785_altered_susceptibility_to1.89484554
21MP0002452_abnormal_antigen_presenting1.89038845
22MP0005167_abnormal_blood-brain_barrier1.87299529
23MP0005671_abnormal_response_to1.86702032
24MP0001800_abnormal_humoral_immune1.83927772
25MP0000465_gastrointestinal_hemorrhage1.81623278
26MP0000685_abnormal_immune_system1.77379120
27* MP0002723_abnormal_immune_serum1.77378320
28MP0003279_aneurysm1.76431454
29MP0004947_skin_inflammation1.76235064
30* MP0002405_respiratory_system_inflammati1.75209652
31MP0005025_abnormal_response_to1.73228260
32MP0002166_altered_tumor_susceptibility1.71217985
33MP0003453_abnormal_keratinocyte_physiol1.67984233
34MP0004510_myositis1.67175629
35MP0002420_abnormal_adaptive_immunity1.62165681
36MP0000343_altered_response_to1.61641252
37MP0001819_abnormal_immune_cell1.59893676
38MP0002722_abnormal_immune_system1.53250523
39MP0001545_abnormal_hematopoietic_system1.53202240
40MP0005397_hematopoietic_system_phenotyp1.53202240
41MP0001873_stomach_inflammation1.52871546
42MP0002877_abnormal_melanocyte_morpholog1.51943111
43* MP0001533_abnormal_skeleton_physiology1.50072790
44MP0006082_CNS_inflammation1.47503687
45MP0003866_abnormal_defecation1.47353137
46MP0004883_abnormal_blood_vessel1.45217512
47MP0003075_altered_response_to1.44872263
48MP0002933_joint_inflammation1.44578327
49MP0005164_abnormal_response_to1.43652759
50MP0003943_abnormal_hepatobiliary_system1.43435109
51MP0005464_abnormal_platelet_physiology1.39564574
52MP0010155_abnormal_intestine_physiology1.38653645
53MP0002060_abnormal_skin_morphology1.38382971
54MP0003300_gastrointestinal_ulcer1.37610012
55MP0010678_abnormal_skin_adnexa1.37509864
56MP0003448_altered_tumor_morphology1.36863352
57MP0001986_abnormal_taste_sensitivity1.35879672
58MP0004272_abnormal_basement_membrane1.33675254
59MP0000703_abnormal_thymus_morphology1.33531977
60MP0002998_abnormal_bone_remodeling1.31667078
61MP0005409_darkened_coat_color1.31141285
62MP0006054_spinal_hemorrhage1.29275322
63MP0009840_abnormal_foam_cell1.28570448
64MP0003136_yellow_coat_color1.27149842
65MP0000767_abnormal_smooth_muscle1.22563299
66MP0002006_tumorigenesis1.22380375
67MP0003656_abnormal_erythrocyte_physiolo1.21709977
68MP0002277_abnormal_respiratory_mucosa1.21224059
69MP0002138_abnormal_hepatobiliary_system1.18830852
70MP0002132_abnormal_respiratory_system1.17961992
71MP0009333_abnormal_splenocyte_physiolog1.17823819
72* MP0001845_abnormal_inflammatory_respons1.17065407
73MP0000249_abnormal_blood_vessel1.16524537
74MP0005165_increased_susceptibility_to1.16141643
75MP0009764_decreased_sensitivity_to1.15184368
76MP0002396_abnormal_hematopoietic_system1.13508618
77MP0003941_abnormal_skin_development1.12155062
78MP0003195_calcinosis1.10905102
79MP0002876_abnormal_thyroid_physiology1.07634272
80MP0002928_abnormal_bile_duct1.07067243
81MP0004782_abnormal_surfactant_physiolog1.06215908
82MP0006072_abnormal_retinal_apoptosis1.06020352
83* MP0005390_skeleton_phenotype1.05273401
84MP0005023_abnormal_wound_healing1.05165688
85MP0003252_abnormal_bile_duct1.03681764
86MP0004808_abnormal_hematopoietic_stem1.03419894
87MP0001216_abnormal_epidermal_layer1.02765755
88MP0000716_abnormal_immune_system1.01925801
89MP0002295_abnormal_pulmonary_circulatio1.01073150
90MP0003191_abnormal_cellular_cholesterol1.00543837
91MP0004147_increased_porphyrin_level1.00214402
92MP0003763_abnormal_thymus_physiology1.00049285
93MP0002098_abnormal_vibrissa_morphology0.99836445
94MP0001346_abnormal_lacrimal_gland0.99747105
95MP0005058_abnormal_lysosome_morphology0.97383547
96MP0000858_altered_metastatic_potential0.97259681
97MP0009379_abnormal_foot_pigmentation0.97119502
98MP0005075_abnormal_melanosome_morpholog0.95903568
99MP0001958_emphysema0.95829826
100MP0003566_abnormal_cell_adhesion0.93793709
101MP0001191_abnormal_skin_condition0.92325118
102MP0003690_abnormal_glial_cell0.92060488
103MP0005084_abnormal_gallbladder_morpholo0.91897086
104MP0001542_abnormal_bone_strength0.91406771
105MP0002796_impaired_skin_barrier0.91026227
106MP0002398_abnormal_bone_marrow0.90816215
107MP0001501_abnormal_sleep_pattern0.90636393
108MP0004130_abnormal_muscle_cell0.89759113
109MP0005310_abnormal_salivary_gland0.89121369
110MP0008875_abnormal_xenobiotic_pharmacok0.86588816
111MP0005166_decreased_susceptibility_to0.86285129
112MP0001919_abnormal_reproductive_system0.85683507
113* MP0008469_abnormal_protein_level0.85137911
114MP0002429_abnormal_blood_cell0.81570794
115MP0000689_abnormal_spleen_morphology0.81539106
116MP0003795_abnormal_bone_structure0.81035139
117MP0008004_abnormal_stomach_pH0.80580214
118MP0005377_hearing/vestibular/ear_phenot0.79236682
119MP0003878_abnormal_ear_physiology0.79236682
120MP0003638_abnormal_response/metabolism_0.77739789
121MP0004484_altered_response_of0.74909339
122MP0001765_abnormal_ion_homeostasis0.73181460
123* MP0009763_increased_sensitivity_to0.69238643
124MP0000604_amyloidosis0.66151061
125MP0002136_abnormal_kidney_physiology0.63875840
126MP0000013_abnormal_adipose_tissue0.60396841
127MP0009765_abnormal_xenobiotic_induced0.60016108
128MP0005076_abnormal_cell_differentiation0.59382904
129MP0005535_abnormal_body_temperature0.59253017
130MP0002332_abnormal_exercise_endurance0.59060053
131MP0004885_abnormal_endolymph0.56212219
132MP0003183_abnormal_peptide_metabolism0.52254184
133MP0003045_fibrosis0.52004307

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.94178141
2Recurrent abscess formation (HP:0002722)4.23532497
3T lymphocytopenia (HP:0005403)3.99443317
4Abnormality of T cell number (HP:0011839)3.91983282
5Prostate neoplasm (HP:0100787)3.86773148
6Orchitis (HP:0100796)3.78771614
7Severe combined immunodeficiency (HP:0004430)3.72544234
8Recurrent bacterial skin infections (HP:0005406)3.65308203
9Eczematoid dermatitis (HP:0000976)3.64930136
10Myositis (HP:0100614)3.63262057
11Spontaneous hematomas (HP:0007420)3.60823323
12Optic neuritis (HP:0100653)3.59785607
13Retrobulbar optic neuritis (HP:0100654)3.59785607
14Stomach cancer (HP:0012126)3.57876591
15Hematochezia (HP:0002573)3.49278865
16Abnormality of T cells (HP:0002843)3.48892961
17Systemic lupus erythematosus (HP:0002725)3.46959296
18Abnormality of eosinophils (HP:0001879)3.44728871
19Thick nail (HP:0001805)3.40844092
20Gastrointestinal infarctions (HP:0005244)3.03243158
21Parakeratosis (HP:0001036)3.02257877
22Abnormality of T cell physiology (HP:0011840)3.00435270
23Elevated erythrocyte sedimentation rate (HP:0003565)2.99955820
24Persistence of primary teeth (HP:0006335)2.99938606
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.97276481
26Premature loss of primary teeth (HP:0006323)2.88459779
27Anhidrosis (HP:0000970)2.85905106
28Vacuolated lymphocytes (HP:0001922)2.83844904
29Glomerulonephritis (HP:0000099)2.79531335
30Thyroiditis (HP:0100646)2.78671171
31Eosinophilia (HP:0001880)2.76643084
32Pulmonary artery stenosis (HP:0004415)2.76066015
33Abnormality of B cell number (HP:0010975)2.75025114
34Granulocytopenia (HP:0001913)2.74512771
35Distal lower limb muscle weakness (HP:0009053)2.71909191
36Segmental peripheral demyelination/remyelination (HP:0003481)2.69401867
37Combined immunodeficiency (HP:0005387)2.67663868
38Chronic mucocutaneous candidiasis (HP:0002728)2.65664674
39Recurrent cutaneous fungal infections (HP:0011370)2.65664674
40Gangrene (HP:0100758)2.64318154
41Pulmonary fibrosis (HP:0002206)2.62979547
42Episodic fever (HP:0001954)2.60294714
43Recurrent bronchitis (HP:0002837)2.59130644
44Alveolar cell carcinoma (HP:0006519)2.48925523
45Vascular tortuosity (HP:0004948)2.48501816
46Petechiae (HP:0000967)2.48336580
47Prolonged bleeding time (HP:0003010)2.47825906
48Autoimmune thrombocytopenia (HP:0001973)2.45571657
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.43356772
50Milia (HP:0001056)2.42850392
51Abnormality of macrophages (HP:0004311)2.40522964
52Abnormality of the nasal mucosa (HP:0000433)2.39094968
53Interstitial pulmonary disease (HP:0006530)2.38422973
54Encephalitis (HP:0002383)2.37423321
55Arterial tortuosity (HP:0005116)2.37012458
56Recurrent skin infections (HP:0001581)2.36632354
57Joint swelling (HP:0001386)2.36267479
58Increased IgE level (HP:0003212)2.35484529
59Recurrent fungal infections (HP:0002841)2.33213052
60Chronic otitis media (HP:0000389)2.32989696
61Keratitis (HP:0000491)2.31982480
62White forelock (HP:0002211)2.31802679
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.31645034
64Osteolytic defects of the hand bones (HP:0009699)2.31645034
65Abnormality of male internal genitalia (HP:0000022)2.30904310
66Panhypogammaglobulinemia (HP:0003139)2.28125391
67Epistaxis (HP:0000421)2.27888835
68Chronic obstructive pulmonary disease (HP:0006510)2.27565354
69Obstructive lung disease (HP:0006536)2.27565354
70Abnormality of the pleura (HP:0002103)2.26370999
71Patchy hypopigmentation of hair (HP:0011365)2.26320502
72Cellulitis (HP:0100658)2.26150460
73Arterial thrombosis (HP:0004420)2.24223335
74Congenital, generalized hypertrichosis (HP:0004540)2.23614792
75Colitis (HP:0002583)2.22604152
76Increased IgM level (HP:0003496)2.22586324
77Neoplasm of the tracheobronchial system (HP:0100552)2.21293989
78Pustule (HP:0200039)2.21120693
79Aplasia cutis congenita (HP:0001057)2.21016682
80Inflammation of the large intestine (HP:0002037)2.20036703
81Anorexia (HP:0002039)2.19953565
82Keratoconjunctivitis sicca (HP:0001097)2.18651750
83Pulmonary infiltrates (HP:0002113)2.18157758
84Mediastinal lymphadenopathy (HP:0100721)2.17853047
85Stomatitis (HP:0010280)2.17661579
86Conical tooth (HP:0000698)2.17426286
87Premature skin wrinkling (HP:0100678)2.16996833
88Abnormality of the axillary hair (HP:0100134)2.16376282
89Abnormality of secondary sexual hair (HP:0009888)2.16376282
90Abnormality of polysaccharide metabolism (HP:0011012)2.15833392
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15833392
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15833392
93Submucous cleft hard palate (HP:0000176)2.15557501
94Growth hormone excess (HP:0000845)2.13832466
95Vasculitis (HP:0002633)2.13756108
96Hemoptysis (HP:0002105)2.13727106
97Axonal loss (HP:0003447)2.12734477
98Increased density of long bones (HP:0006392)2.12646823
99Abnormality of the prostate (HP:0008775)2.10907644
100Dysostosis multiplex (HP:0000943)2.10876542
101Increased cerebral lipofuscin (HP:0011813)2.10663169
102B lymphocytopenia (HP:0010976)2.10447877
103Pancreatitis (HP:0001733)2.10355899
104Cheilitis (HP:0100825)2.10330410
105Vertigo (HP:0002321)2.10249204
106Portal hypertension (HP:0001409)2.09464794
107Urinary glycosaminoglycan excretion (HP:0003541)2.08585578
108Mucopolysacchariduria (HP:0008155)2.08585578
109Nephritis (HP:0000123)2.08256409
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07807693
111Autoimmune hemolytic anemia (HP:0001890)2.07159463
112Adactyly (HP:0009776)2.07111933
113Pulmonary embolism (HP:0002204)2.06815446
114Keratoconjunctivitis (HP:0001096)2.04926921
115Amyloidosis (HP:0011034)2.03204289
116Agammaglobulinemia (HP:0004432)2.03184658
117Ulnar claw (HP:0001178)2.01545786
118Periodontitis (HP:0000704)2.01314589
119IgM deficiency (HP:0002850)2.01015822
120Glomerulopathy (HP:0100820)1.99408408
121Plantar hyperkeratosis (HP:0007556)1.96861062
122Urticaria (HP:0001025)1.96529699
123Myocardial infarction (HP:0001658)1.96426034
124Lip pit (HP:0100267)1.95808869
125Recurrent viral infections (HP:0004429)1.95559518
126Congenital stationary night blindness (HP:0007642)1.95372704
127Polyneuropathy (HP:0001271)1.94254667
128Clumsiness (HP:0002312)1.94208240
129Papilloma (HP:0012740)1.93676716
130Verrucae (HP:0200043)1.93676716
131Gastrointestinal inflammation (HP:0004386)1.93513217
132Acanthosis nigricans (HP:0000956)1.92452999
133Asymmetric septal hypertrophy (HP:0001670)1.91824102
134Xerostomia (HP:0000217)1.91592416
135Atrophic scars (HP:0001075)1.91582456
136Polycythemia (HP:0001901)1.90063487
137Onycholysis (HP:0001806)1.89967114
138Hypergammaglobulinemia (HP:0010702)1.89013325
139Chronic diarrhea (HP:0002028)1.88657261
140Chest pain (HP:0100749)1.87531562
141Joint stiffness (HP:0001387)1.87416354
142Abnormality of the pericardium (HP:0001697)1.87344753
143Abnormality of the hepatic vasculature (HP:0006707)1.86825975
144Joint hemorrhage (HP:0005261)1.86286599
145Leukocytosis (HP:0001974)1.86276674
146Alopecia of scalp (HP:0002293)1.85912462
147Progressive visual loss (HP:0000529)1.85184741
148Esophageal varix (HP:0002040)1.84948540
149Absent hand (HP:0004050)1.83071719
150Hypotrichosis (HP:0001006)1.80884016
151Purpura (HP:0000979)1.80011700
152Recurrent gram-negative bacterial infections (HP:0005420)1.78458469
153Ectropion (HP:0000656)1.78458434
154Upper limb muscle weakness (HP:0003484)1.76303452
155Gingival bleeding (HP:0000225)1.74916604
156Spondylolisthesis (HP:0003302)1.74548380
157Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72281128
158Meningitis (HP:0001287)1.71870437
159Gingivitis (HP:0000230)1.71024810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.25278322
2TIE14.18927153
3GRK63.74050244
4TGFBR23.71015079
5MAP3K142.75821042
6MAPKAPK52.32058821
7KDR2.30975639
8TESK22.20975548
9EPHB12.13031114
10IKBKB2.10391124
11GRK71.90248205
12IRAK31.84139010
13TEC1.78693937
14TYK21.77289925
15MAP3K131.77146330
16TLK11.74000623
17MST41.73165926
18VRK11.71035195
19IKBKE1.69506452
20IRAK41.66478616
21TBK11.59613792
22MAP3K31.57666352
23TXK1.56434875
24NLK1.53274986
25TRPM71.51946116
26STK101.44154232
27* MAP2K21.43788595
28BLK1.40018171
29MAP4K11.37394670
30PIM21.36396806
31CHUK1.31724109
32MAPK71.31078137
33BMPR1B1.28770225
34KIT1.25074582
35INSRR1.22722309
36TSSK61.13921806
37ADRBK21.13340678
38IRAK11.08869674
39ITK1.08416610
40GRK11.06637188
41TGFBR11.05144851
42JAK31.04201687
43BTK1.02993336
44EPHA31.01614405
45JAK10.96764825
46EPHA20.95819831
47TNK20.94431285
48CLK10.93602387
49CSK0.91985978
50MAP2K30.91021136
51ZAP700.85647757
52GSK3A0.85059043
53HIPK20.84703435
54MAPK40.84643002
55CSF1R0.84342278
56CDK30.84191849
57MAP3K70.83312940
58MAP4K20.83229128
59MAPKAPK20.80047609
60MOS0.73018781
61HCK0.69347628
62MATK0.68480342
63DMPK0.67667706
64PRKCQ0.67332127
65RPS6KA60.67331267
66LCK0.65310570
67BMPR20.64759422
68BCKDK0.63901332
69RPS6KA50.63858147
70RPS6KL10.63130072
71RPS6KC10.63130072
72PAK20.62779301
73MAP3K120.62075568
74TAOK30.61492117
75MAP3K10.60439777
76CDC42BPA0.59420578
77NEK60.59316913
78RPS6KA10.57789055
79CDK80.57109185
80NUAK10.56521548
81MAPK120.56362787
82PRKD20.56232771
83MYLK0.55705011
84MAPKAPK30.54598462
85MARK30.54487261
86EIF2AK20.53735367
87PIM10.52542990
88MAP3K110.52488497
89PINK10.51491462
90DAPK20.51435162
91RPS6KA20.50243272
92PTK2B0.49970122
93PDK20.49841229
94FGFR30.49730619
95PRKAA20.49095040
96GRK50.49031121
97FGR0.48862162
98LYN0.48744270
99EPHB20.48532285
100PDK10.48530413
101FRK0.47421668
102ERN10.45589613
103CAMKK20.45545930
104PRKG20.45323720
105ABL10.44257855
106MAP2K60.44249842
107RIPK40.43797181
108PIK3CA0.43482210
109PRKD10.42975860
110RPS6KB20.42042376
111WNK40.41865773
112CAMK1D0.41820870
113FES0.40489373
114JAK20.40147693
115MAPK110.39341961
116ZAK0.37466542
117PKN10.37464746
118SYK0.37393353
119PRKCE0.36661502
120MUSK0.36066296
121IRAK20.35813545
122IGF1R0.35798263
123CAMK1G0.35783494
124ADRBK10.35620816
125SIK30.35556116
126FGFR40.35133341
127* MAPK30.32962038
128FLT30.31970227
129INSR0.31846661
130PIK3CG0.31672076
131PRKCD0.29482194
132CDK40.28477871

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.78662887
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69985897
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54436781
4Osteoclast differentiation_Homo sapiens_hsa043802.46415468
5Pertussis_Homo sapiens_hsa051332.10556203
6Malaria_Homo sapiens_hsa051442.08993860
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.06237245
8Rheumatoid arthritis_Homo sapiens_hsa053231.95137793
9Staphylococcus aureus infection_Homo sapiens_hsa051501.90316978
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89953318
11TNF signaling pathway_Homo sapiens_hsa046681.87506345
12B cell receptor signaling pathway_Homo sapiens_hsa046621.81898752
13Hematopoietic cell lineage_Homo sapiens_hsa046401.80913200
14Type I diabetes mellitus_Homo sapiens_hsa049401.79431434
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71626971
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.66960139
17Toxoplasmosis_Homo sapiens_hsa051451.66674493
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54221982
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52434790
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.48453586
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.47089337
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47010039
23Measles_Homo sapiens_hsa051621.42592371
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.40844096
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39944308
26Other glycan degradation_Homo sapiens_hsa005111.39262134
27Salmonella infection_Homo sapiens_hsa051321.35778286
28Legionellosis_Homo sapiens_hsa051341.34266663
29Apoptosis_Homo sapiens_hsa042101.28717362
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21203955
31Notch signaling pathway_Homo sapiens_hsa043301.19853561
32Antigen processing and presentation_Homo sapiens_hsa046121.19235725
33ECM-receptor interaction_Homo sapiens_hsa045121.17201666
34Influenza A_Homo sapiens_hsa051641.15434053
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12880990
36African trypanosomiasis_Homo sapiens_hsa051431.12551011
37Sphingolipid metabolism_Homo sapiens_hsa006001.11024612
38T cell receptor signaling pathway_Homo sapiens_hsa046601.10836513
39Graft-versus-host disease_Homo sapiens_hsa053321.10377929
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09633940
41Tuberculosis_Homo sapiens_hsa051521.08959624
42Platelet activation_Homo sapiens_hsa046111.06388911
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03652422
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.02071384
45Hepatitis B_Homo sapiens_hsa051611.01729496
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01330213
47Allograft rejection_Homo sapiens_hsa053301.01008168
48Chemokine signaling pathway_Homo sapiens_hsa040621.00735422
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96766272
50Lysosome_Homo sapiens_hsa041420.95780771
51Ether lipid metabolism_Homo sapiens_hsa005650.95779344
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95060105
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94408061
54Amoebiasis_Homo sapiens_hsa051460.92835223
55Herpes simplex infection_Homo sapiens_hsa051680.92275702
56Primary immunodeficiency_Homo sapiens_hsa053400.89112445
57Asthma_Homo sapiens_hsa053100.88579273
58Shigellosis_Homo sapiens_hsa051310.83713744
59Nitrogen metabolism_Homo sapiens_hsa009100.83658793
60Hepatitis C_Homo sapiens_hsa051600.83432408
61Focal adhesion_Homo sapiens_hsa045100.83181851
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81763499
63Arachidonic acid metabolism_Homo sapiens_hsa005900.80890727
64Small cell lung cancer_Homo sapiens_hsa052220.80175229
65Dorso-ventral axis formation_Homo sapiens_hsa043200.79257283
66Complement and coagulation cascades_Homo sapiens_hsa046100.79200618
67Autoimmune thyroid disease_Homo sapiens_hsa053200.76104212
68Adherens junction_Homo sapiens_hsa045200.75370182
69Acute myeloid leukemia_Homo sapiens_hsa052210.74577654
70Linoleic acid metabolism_Homo sapiens_hsa005910.72931053
71Phagosome_Homo sapiens_hsa041450.72908018
72HTLV-I infection_Homo sapiens_hsa051660.72163225
73Pathways in cancer_Homo sapiens_hsa052000.71066621
74Tryptophan metabolism_Homo sapiens_hsa003800.69965847
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68064919
76Circadian rhythm_Homo sapiens_hsa047100.67976929
77TGF-beta signaling pathway_Homo sapiens_hsa043500.67597425
78ABC transporters_Homo sapiens_hsa020100.67415425
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66583081
80Rap1 signaling pathway_Homo sapiens_hsa040150.66554728
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66422821
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66271080
83Prolactin signaling pathway_Homo sapiens_hsa049170.66128051
84Vitamin digestion and absorption_Homo sapiens_hsa049770.66082583
85Prion diseases_Homo sapiens_hsa050200.65735252
86Renin secretion_Homo sapiens_hsa049240.65707428
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64758081
88Phototransduction_Homo sapiens_hsa047440.64444098
89Chronic myeloid leukemia_Homo sapiens_hsa052200.64391589
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64365545
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64297620
92Caffeine metabolism_Homo sapiens_hsa002320.62870977
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61783589
94* MAPK signaling pathway_Homo sapiens_hsa040100.61606298
95Ras signaling pathway_Homo sapiens_hsa040140.61395104
96Proteoglycans in cancer_Homo sapiens_hsa052050.60300863
97Prostate cancer_Homo sapiens_hsa052150.58702685
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58214531
99Phenylalanine metabolism_Homo sapiens_hsa003600.57162490
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56985914
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55841494
102Viral myocarditis_Homo sapiens_hsa054160.55437751
103Estrogen signaling pathway_Homo sapiens_hsa049150.54739631
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53526806
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.52823973
106Pancreatic cancer_Homo sapiens_hsa052120.52672571
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51465188
108Renal cell carcinoma_Homo sapiens_hsa052110.50485817
109Colorectal cancer_Homo sapiens_hsa052100.50475262
110Endocytosis_Homo sapiens_hsa041440.48930766
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48332996
112Ovarian steroidogenesis_Homo sapiens_hsa049130.46979005
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46924850
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46741144
115Choline metabolism in cancer_Homo sapiens_hsa052310.46636646
116Histidine metabolism_Homo sapiens_hsa003400.45397782
117Regulation of autophagy_Homo sapiens_hsa041400.44924746
118Cocaine addiction_Homo sapiens_hsa050300.44110934
119Epstein-Barr virus infection_Homo sapiens_hsa051690.38599065
120Insulin resistance_Homo sapiens_hsa049310.36319204
121Morphine addiction_Homo sapiens_hsa050320.33608888
122Chemical carcinogenesis_Homo sapiens_hsa052040.30648084
123Salivary secretion_Homo sapiens_hsa049700.30575855
124FoxO signaling pathway_Homo sapiens_hsa040680.24529285
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.24312316
126Oxytocin signaling pathway_Homo sapiens_hsa049210.21598988
127Glycerolipid metabolism_Homo sapiens_hsa005610.19070168
128cAMP signaling pathway_Homo sapiens_hsa040240.18768063
129Olfactory transduction_Homo sapiens_hsa047400.17286999
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.16563109

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