DUSP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.32460137
2cullin deneddylation (GO:0010388)5.20006806
3protein deneddylation (GO:0000338)5.12632889
4platelet dense granule organization (GO:0060155)4.61453022
5DNA deamination (GO:0045006)4.48679294
6DNA double-strand break processing (GO:0000729)4.37558751
7cytoplasmic mRNA processing body assembly (GO:0033962)4.12248694
8positive regulation of gamma-delta T cell activation (GO:0046645)3.93730505
9DNA catabolic process, exonucleolytic (GO:0000738)3.93497897
10negative regulation of cell killing (GO:0031342)3.83628182
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83628182
12respiratory chain complex IV assembly (GO:0008535)3.81623821
13pseudouridine synthesis (GO:0001522)3.75610749
14protein neddylation (GO:0045116)3.74945476
15regulation of gamma-delta T cell differentiation (GO:0045586)3.73776452
16negative T cell selection (GO:0043383)3.70078967
17protein complex biogenesis (GO:0070271)3.59932934
18negative thymic T cell selection (GO:0045060)3.55526220
19somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.55375007
20isotype switching (GO:0045190)3.55375007
21somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.55375007
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54172308
23positive regulation of histone deacetylation (GO:0031065)3.49410364
24mitochondrial respiratory chain complex assembly (GO:0033108)3.44008204
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40408458
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40200244
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39543269
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37968859
29cytochrome complex assembly (GO:0017004)3.37782347
30positive thymic T cell selection (GO:0045059)3.36679625
31regulation of mitochondrial translation (GO:0070129)3.33301995
32regulation of gamma-delta T cell activation (GO:0046643)3.32347617
33regulation of mitotic spindle checkpoint (GO:1903504)3.29214419
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.29214419
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27587862
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26502618
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.26502618
38NADH dehydrogenase complex assembly (GO:0010257)3.26502618
39cytidine metabolic process (GO:0046087)3.25056297
40cytidine catabolic process (GO:0006216)3.25056297
41cytidine deamination (GO:0009972)3.25056297
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21647584
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21647584
44thymic T cell selection (GO:0045061)3.19692093
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18989975
46regulation of cellular amino acid metabolic process (GO:0006521)3.18978630
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16341292
48protein localization to endosome (GO:0036010)3.15684216
49positive T cell selection (GO:0043368)3.12988039
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11659950
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11659950
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11659950
53maturation of 5.8S rRNA (GO:0000460)3.10622213
54T cell selection (GO:0045058)3.10595846
55DNA demethylation (GO:0080111)3.09992215
56L-methionine salvage (GO:0071267)3.09886541
57L-methionine biosynthetic process (GO:0071265)3.09886541
58amino acid salvage (GO:0043102)3.09886541
59regulation of T cell tolerance induction (GO:0002664)3.09684730
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06795312
61intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06795312
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06204834
63histone H3-K4 trimethylation (GO:0080182)3.02823445
64growth hormone receptor signaling pathway (GO:0060396)3.00790237
65negative regulation of ligase activity (GO:0051352)2.98933347
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98933347
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98692935
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98692935
69antigen processing and presentation of endogenous antigen (GO:0019883)2.97129352
70rRNA modification (GO:0000154)2.96783983
71protein-cofactor linkage (GO:0018065)2.96659881
72negative regulation of telomere maintenance (GO:0032205)2.94897072
73GPI anchor metabolic process (GO:0006505)2.93940974
74regulation of interleukin-12 biosynthetic process (GO:0045075)2.93685455
75ATP synthesis coupled proton transport (GO:0015986)2.91689614
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91689614
77ubiquinone biosynthetic process (GO:0006744)2.91489915
78signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91123780
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.91123780
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90244996
81signal transduction involved in cell cycle checkpoint (GO:0072395)2.88590744
82hepatocyte apoptotic process (GO:0097284)2.87522455
83preassembly of GPI anchor in ER membrane (GO:0016254)2.87409374
84termination of RNA polymerase III transcription (GO:0006386)2.86947989
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.86947989
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86327469
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86294143
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84323962
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.84323962
90anterograde synaptic vesicle transport (GO:0048490)2.84172690
91regulation of meiosis I (GO:0060631)2.83654070
92piRNA metabolic process (GO:0034587)2.82939272
93resolution of meiotic recombination intermediates (GO:0000712)2.82516433
94tRNA processing (GO:0008033)2.81555871
95pyrimidine ribonucleoside catabolic process (GO:0046133)2.80640087
96synapsis (GO:0007129)2.80300150
97adenosine metabolic process (GO:0046085)2.80061773
98embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79857579
99signal peptide processing (GO:0006465)2.79478372
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76304954
101rRNA catabolic process (GO:0016075)2.75896325
102replication fork processing (GO:0031297)2.74504109
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.73247088
104ribosome assembly (GO:0042255)2.70519250
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68885269
106cellular response to growth hormone stimulus (GO:0071378)2.68498674
107mitochondrial RNA metabolic process (GO:0000959)2.68186354
108peptidyl-histidine modification (GO:0018202)2.67892922
109cellular response to interleukin-15 (GO:0071350)2.67559532
110cortical actin cytoskeleton organization (GO:0030866)2.67419120
111positive regulation of ligase activity (GO:0051351)2.67189523
112GPI anchor biosynthetic process (GO:0006506)2.67130934
113ubiquinone metabolic process (GO:0006743)2.65618399
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.63733509
115somatic diversification of immunoglobulins (GO:0016445)2.63205220
116DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.62907444
117tRNA metabolic process (GO:0006399)2.62847700
118water-soluble vitamin biosynthetic process (GO:0042364)2.62531868
119chaperone-mediated protein transport (GO:0072321)2.61983450
120methionine biosynthetic process (GO:0009086)2.58889650
121protein K6-linked ubiquitination (GO:0085020)2.56918263
122negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53846836
123negative regulation of translation, ncRNA-mediated (GO:0040033)2.53846836
124regulation of translation, ncRNA-mediated (GO:0045974)2.53846836
125mannosylation (GO:0097502)2.53203169
126DNA dealkylation (GO:0035510)2.52234380
127regulation of memory T cell differentiation (GO:0043380)2.50510863
128histone H3-K4 methylation (GO:0051568)2.48501604
129positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48421589
130positive regulation of oligodendrocyte differentiation (GO:0048714)2.48343167
131response to pheromone (GO:0019236)2.48258984
132T cell costimulation (GO:0031295)2.45799720
133regulation of histone deacetylation (GO:0031063)2.45312518
134regulation of extracellular matrix disassembly (GO:0010715)2.42134910
135activated T cell proliferation (GO:0050798)2.41404277
136positive regulation of interleukin-2 production (GO:0032743)2.41116649
137lymphocyte costimulation (GO:0031294)2.39893774
138regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.39122172
139positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.39122172
140regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.38322620
141insulin-like growth factor receptor signaling pathway (GO:0048009)2.35674802
142tolerance induction (GO:0002507)2.35470851
143mitotic sister chromatid cohesion (GO:0007064)2.34796779
144histone H3-K36 demethylation (GO:0070544)2.34605490
145cortical cytoskeleton organization (GO:0030865)2.32203317
146T cell receptor signaling pathway (GO:0050852)2.30943635
147positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.30340018
148regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.30340018
149JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.28792448
150coronary vasculature morphogenesis (GO:0060977)2.28620456
151positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28595905
152regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.27167389
153response to interleukin-15 (GO:0070672)2.25042744
154nerve growth factor signaling pathway (GO:0038180)2.24741002
155I-kappaB phosphorylation (GO:0007252)2.23493065
156heterotypic cell-cell adhesion (GO:0034113)2.22122433
157positive regulation of tolerance induction (GO:0002645)2.20717864
158positive regulation of T cell cytokine production (GO:0002726)2.20298486
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.20278535
160sodium ion export (GO:0071436)2.19905598
161regulation of mRNA catabolic process (GO:0061013)2.19732745
162positive regulation of mRNA catabolic process (GO:0061014)2.18967844
163positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.17300288
164positive regulation of astrocyte differentiation (GO:0048711)2.16754348
165leukocyte aggregation (GO:0070486)2.15469500
166establishment of nucleus localization (GO:0040023)2.12978657
167CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.12751566
168T-helper cell differentiation (GO:0042093)2.12751566
169germ cell migration (GO:0008354)2.12738703
170cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.12579606
171regulation of ARF protein signal transduction (GO:0032012)2.11298953
172lung lobe morphogenesis (GO:0060463)2.09822000
173positive regulation of p38MAPK cascade (GO:1900745)2.09538813
174pinocytosis (GO:0006907)2.09092807
175antigen receptor-mediated signaling pathway (GO:0050851)2.08905952
176T cell migration (GO:0072678)2.07053416
177establishment of endothelial barrier (GO:0061028)2.06749846
178hemidesmosome assembly (GO:0031581)2.05062583
179positive regulation of glial cell differentiation (GO:0045687)2.04534758
180B cell receptor signaling pathway (GO:0050853)2.04495808
181negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.04206821
182response to laminar fluid shear stress (GO:0034616)2.03601002
183embryonic camera-type eye morphogenesis (GO:0048596)2.02846873
184antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.01911677
185positive regulation of macrophage cytokine production (GO:0060907)2.00811368
186hypotonic response (GO:0006971)2.00799170
187natural killer cell differentiation (GO:0001779)2.00748287
188regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.00093786
189regulation of natural killer cell mediated immunity (GO:0002715)2.00093786
190vascular endothelial growth factor signaling pathway (GO:0038084)1.99465303
191regulation of tolerance induction (GO:0002643)1.99448967
192regulation of alpha-beta T cell proliferation (GO:0046640)1.98060067
193gland morphogenesis (GO:0022612)1.96721610
194regulation of p38MAPK cascade (GO:1900744)1.96702841
195positive regulation of Rap GTPase activity (GO:0032854)1.95954106
196mannose metabolic process (GO:0006013)1.95673629
197positive regulation of protein deacetylation (GO:0090312)1.95060086
198regulation of protein deacetylation (GO:0090311)1.94523226
199cell adhesion mediated by integrin (GO:0033627)1.92759822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.39196741
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.34588319
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21454681
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.77045167
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.61071054
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.56432311
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.05215146
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91539196
9ELK1_19687146_ChIP-ChIP_HELA_Human2.90314513
10VDR_22108803_ChIP-Seq_LS180_Human2.80063124
11ZNF274_21170338_ChIP-Seq_K562_Hela2.78928309
12RUNX_20019798_ChIP-Seq_JUKART_Human2.69883681
13* VDR_23849224_ChIP-Seq_CD4+_Human2.67843361
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.59812786
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57769359
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57731248
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45913043
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44751917
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.42783587
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.37724510
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34565556
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.25157446
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24888910
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24206724
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.20818767
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17910866
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12407718
28KDM2B_26808549_Chip-Seq_DND41_Human2.06379123
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04755031
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.02892060
31EWS_26573619_Chip-Seq_HEK293_Human2.01732009
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01416124
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97938617
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.95444837
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92580757
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.91873309
37MYC_22102868_ChIP-Seq_BL_Human1.88303572
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86949184
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85909242
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84921270
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82518847
42TCF7_22412390_ChIP-Seq_EML_Mouse1.82518013
43AR_21572438_ChIP-Seq_LNCaP_Human1.81984336
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80402405
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78535859
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78102542
47MYC_18940864_ChIP-ChIP_HL60_Human1.73635587
48* FOXO3_23340844_ChIP-Seq_DLD1_Human1.72507836
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.72327896
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70927447
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70905765
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.68935608
53CLOCK_20551151_ChIP-Seq_293T_Human1.66076708
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65425983
55MAF_26560356_Chip-Seq_TH1_Human1.64061929
56GATA1_22025678_ChIP-Seq_K562_Human1.62848849
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.61656399
58IRF1_19129219_ChIP-ChIP_H3396_Human1.59300912
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58242078
60MYB_26560356_Chip-Seq_TH2_Human1.55829012
61TAF15_26573619_Chip-Seq_HEK293_Human1.54514975
62P300_19829295_ChIP-Seq_ESCs_Human1.52829535
63FUS_26573619_Chip-Seq_HEK293_Human1.51577906
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50600624
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50553514
66VDR_21846776_ChIP-Seq_THP-1_Human1.49963547
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49855219
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49440664
69UTX_26944678_Chip-Seq_JUKART_Human1.48971744
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48365759
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46399920
72GBX2_23144817_ChIP-Seq_PC3_Human1.46025581
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45629629
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44485204
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44258479
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43069773
77IGF1R_20145208_ChIP-Seq_DFB_Human1.41733744
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40619536
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.39572692
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38771899
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.38698253
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38034448
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.36736311
84ER_23166858_ChIP-Seq_MCF-7_Human1.35317926
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34597382
86KDM2B_26808549_Chip-Seq_K562_Human1.34345470
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33417569
88VDR_24763502_ChIP-Seq_THP-1_Human1.33256864
89MYB_26560356_Chip-Seq_TH1_Human1.32769792
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31780731
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31309670
92GATA1_19941826_ChIP-Seq_K562_Human1.31234728
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30274628
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.30225378
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29679494
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28732015
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28364894
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28307680
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.27870046
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26144203
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.25515030
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23746581
103SOX2_19829295_ChIP-Seq_ESCs_Human1.21626545
104NANOG_19829295_ChIP-Seq_ESCs_Human1.21626545
105* FOXA2_19822575_ChIP-Seq_HepG2_Human1.21401126
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20855271
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20545133
108DCP1A_22483619_ChIP-Seq_HELA_Human1.20523135
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20223043
110CBP_20019798_ChIP-Seq_JUKART_Human1.20223043
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.20107430
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19185897
113GABP_19822575_ChIP-Seq_HepG2_Human1.18275428
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18039220
115VDR_24787735_ChIP-Seq_THP-1_Human1.17211232
116DROSHA_22980978_ChIP-Seq_HELA_Human1.16925539
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16364015
118GATA2_21666600_ChIP-Seq_HMVEC_Human1.16033707
119GATA3_27048872_Chip-Seq_THYMUS_Human1.15741979
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15273637
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14821603
122IRF8_21731497_ChIP-ChIP_J774_Mouse1.14523081
123AHR_22903824_ChIP-Seq_MCF-7_Human1.13684508
124CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13098601
125TP53_22573176_ChIP-Seq_HFKS_Human1.12927626
126ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12525947
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12370418
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12001145
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11103401
130SPI1_23127762_ChIP-Seq_K562_Human1.11095343
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10479000
132AR_20517297_ChIP-Seq_VCAP_Human1.10292321
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.09276875
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08675856
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08482921
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08168210
137GATA3_26560356_Chip-Seq_TH2_Human1.07997725
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07791165
139ESR1_20079471_ChIP-ChIP_T-47D_Human1.07234975
140MYC_18555785_ChIP-Seq_MESCs_Mouse1.07179081
141PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07001398
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06781354
143CRX_20693478_ChIP-Seq_RETINA_Mouse1.06014412
144* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05444793
145* FOXA1_25329375_ChIP-Seq_VCAP_Human1.05444793
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04980878
147RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04693557
148STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04653808
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04075477
150NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04000832
151FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03973991
152NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03194475
153ESR1_21235772_ChIP-Seq_MCF-7_Human1.02762161
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01378863
155SALL4_22934838_ChIP-ChIP_CD34+_Human1.01095606
156* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00706280
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00020246
158FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99722381
159CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99077675
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.98752588
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.98752588
162TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97916046
163CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97652412
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.96809748
165GATA2_19941826_ChIP-Seq_K562_Human0.96640155
166FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95312299
167BCAT_22108803_ChIP-Seq_LS180_Human0.95127184
168FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95044482
169RXR_22108803_ChIP-Seq_LS180_Human0.94957358
170MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94420447
171BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93845805
172SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93842418
173NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93709484
174WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93314049
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93245639
176MAF_26560356_Chip-Seq_TH2_Human0.93208438
177MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92935607
178SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92685656
179CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92448338
180EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92302128
181* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92037557
182RACK7_27058665_Chip-Seq_MCF-7_Human0.91410900
183PU_27001747_Chip-Seq_BMDM_Mouse0.91297839
184CDX2_22108803_ChIP-Seq_LS180_Human0.91101154
185HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91018840
186POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90552102
187CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90038199
188TCF4_22108803_ChIP-Seq_LS180_Human0.89211971
189YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88259050
190PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87545902
191STAT3_18555785_Chip-Seq_ESCs_Mouse0.87008564
192MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86869915
193MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86107853
194* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85651285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer4.43458671
2MP0008058_abnormal_DNA_repair3.55884097
3MP0003806_abnormal_nucleotide_metabolis3.51222229
4MP0010234_abnormal_vibrissa_follicle3.48411644
5MP0002166_altered_tumor_susceptibility3.23258041
6MP0002009_preneoplasia3.08003667
7MP0008877_abnormal_DNA_methylation2.75566800
8MP0005084_abnormal_gallbladder_morpholo2.69235397
9MP0002102_abnormal_ear_morphology2.36432839
10MP0006072_abnormal_retinal_apoptosis2.29955273
11MP0003195_calcinosis2.29710605
12MP0003786_premature_aging2.28052829
13MP0000372_irregular_coat_pigmentation2.23970710
14MP0003045_fibrosis2.22903376
15MP0002006_tumorigenesis2.20209689
16MP0003303_peritoneal_inflammation2.18636204
17MP0010094_abnormal_chromosome_stability2.15763974
18MP0000569_abnormal_digit_pigmentation2.15509768
19MP0010678_abnormal_skin_adnexa2.15001958
20MP0003763_abnormal_thymus_physiology2.08780981
21MP0003186_abnormal_redox_activity2.08186978
22MP0005387_immune_system_phenotype2.01227850
23MP0001790_abnormal_immune_system2.01227850
24MP0002877_abnormal_melanocyte_morpholog1.96413363
25MP0000733_abnormal_muscle_development1.95477766
26MP0003705_abnormal_hypodermis_morpholog1.94952444
27MP0005075_abnormal_melanosome_morpholog1.94158508
28MP0008007_abnormal_cellular_replicative1.93349541
29MP0003091_abnormal_cell_migration1.90350167
30MP0002148_abnormal_hypersensitivity_rea1.86793506
31MP0008057_abnormal_DNA_replication1.84309063
32MP0004947_skin_inflammation1.84070055
33MP0010352_gastrointestinal_tract_polyps1.82693304
34MP0000685_abnormal_immune_system1.80268862
35MP0003718_maternal_effect1.79886749
36MP0008438_abnormal_cutaneous_collagen1.79285514
37MP0000427_abnormal_hair_cycle1.78849102
38MP0000383_abnormal_hair_follicle1.76236385
39MP0005076_abnormal_cell_differentiation1.75170085
40MP0005275_abnormal_skin_tensile1.71862099
41MP0005671_abnormal_response_to1.69223388
42MP0002876_abnormal_thyroid_physiology1.67192953
43MP0005253_abnormal_eye_physiology1.66629949
44MP0001800_abnormal_humoral_immune1.64909273
45MP0002163_abnormal_gland_morphology1.63432929
46MP0004185_abnormal_adipocyte_glucose1.63180347
47MP0008961_abnormal_basal_metabolism1.60091250
48MP0002095_abnormal_skin_pigmentation1.57269318
49MP0000920_abnormal_myelination1.53787910
50MP0001529_abnormal_vocalization1.48565466
51MP0002933_joint_inflammation1.48232111
52MP0009278_abnormal_bone_marrow1.45005952
53MP0001835_abnormal_antigen_presentation1.42203944
54MP0001958_emphysema1.40129242
55MP0003693_abnormal_embryo_hatching1.36313483
56MP0006036_abnormal_mitochondrial_physio1.36121140
57MP0003453_abnormal_keratinocyte_physiol1.35005171
58MP0002452_abnormal_antigen_presenting1.34527350
59MP0010155_abnormal_intestine_physiology1.32474409
60MP0005551_abnormal_eye_electrophysiolog1.32138474
61MP0009384_cardiac_valve_regurgitation1.31621040
62MP0005000_abnormal_immune_tolerance1.31035453
63MP0003011_delayed_dark_adaptation1.30091028
64MP0003436_decreased_susceptibility_to1.29705019
65MP0008789_abnormal_olfactory_epithelium1.28368476
66MP0001299_abnormal_eye_distance/1.28229085
67MP0005410_abnormal_fertilization1.27844118
68MP0002796_impaired_skin_barrier1.27201927
69MP0009764_decreased_sensitivity_to1.27154518
70MP0002420_abnormal_adaptive_immunity1.26642667
71MP0000377_abnormal_hair_follicle1.24203285
72MP0001819_abnormal_immune_cell1.24076327
73MP0008995_early_reproductive_senescence1.22756053
74MP0001879_abnormal_lymphatic_vessel1.22421388
75MP0002723_abnormal_immune_serum1.21736440
76MP0004142_abnormal_muscle_tone1.20993378
77MP0004957_abnormal_blastocyst_morpholog1.20764348
78MP0001929_abnormal_gametogenesis1.19691413
79MP0006035_abnormal_mitochondrial_morpho1.18864056
80MP0008872_abnormal_physiological_respon1.18762856
81MP0002098_abnormal_vibrissa_morphology1.17880919
82MP0002398_abnormal_bone_marrow1.17844874
83MP0001764_abnormal_homeostasis1.17598528
84MP0008875_abnormal_xenobiotic_pharmacok1.17225459
85MP0002060_abnormal_skin_morphology1.16846955
86MP0001119_abnormal_female_reproductive1.15862637
87MP0004381_abnormal_hair_follicle1.15343802
88MP0000703_abnormal_thymus_morphology1.14668442
89MP0000689_abnormal_spleen_morphology1.13872100
90MP0001873_stomach_inflammation1.13466222
91MP0002254_reproductive_system_inflammat1.13366145
92MP0005389_reproductive_system_phenotype1.13157349
93MP0003566_abnormal_cell_adhesion1.12314779
94MP0001851_eye_inflammation1.11640423
95MP0005646_abnormal_pituitary_gland1.11225481
96MP0000716_abnormal_immune_system1.10974889
97MP0002938_white_spotting1.10929856
98MP0009780_abnormal_chondrocyte_physiolo1.08727313
99MP0003866_abnormal_defecation1.08653129
100MP0002998_abnormal_bone_remodeling1.07494128
101MP0003077_abnormal_cell_cycle1.07339317
102MP0006054_spinal_hemorrhage1.07033089
103MP0004808_abnormal_hematopoietic_stem1.05454954
104MP0004885_abnormal_endolymph1.05273172
105MP0003448_altered_tumor_morphology1.04718735
106MP0002736_abnormal_nociception_after1.04171257
107MP0002210_abnormal_sex_determination1.03779811
108MP0006082_CNS_inflammation1.03687381
109MP0001216_abnormal_epidermal_layer1.03062595
110MP0002277_abnormal_respiratory_mucosa1.00459469
111MP0000358_abnormal_cell_content/1.00134804
112MP0000465_gastrointestinal_hemorrhage0.99509684
113MP0008932_abnormal_embryonic_tissue0.99066624
114MP0003690_abnormal_glial_cell0.99046477
115MP0002405_respiratory_system_inflammati0.97337804
116MP0003252_abnormal_bile_duct0.96929962
117MP0000579_abnormal_nail_morphology0.94610236
118MP0005503_abnormal_tendon_morphology0.93892414
119MP0000647_abnormal_sebaceous_gland0.93069324
120MP0000653_abnormal_sex_gland0.92867913
121MP0005645_abnormal_hypothalamus_physiol0.92357593
122MP0005023_abnormal_wound_healing0.91548323
123MP0001919_abnormal_reproductive_system0.91404867
124MP0004272_abnormal_basement_membrane0.90742317
125MP0001346_abnormal_lacrimal_gland0.90240152
126MP0009697_abnormal_copulation0.90128383
127MP0005174_abnormal_tail_pigmentation0.90030779
128MP0005375_adipose_tissue_phenotype0.89399045
129MP0000003_abnormal_adipose_tissue0.89337410
130MP0004264_abnormal_extraembryonic_tissu0.89123341
131MP0003950_abnormal_plasma_membrane0.88734490
132MP0002234_abnormal_pharynx_morphology0.88548902
133MP0001542_abnormal_bone_strength0.88339612
134MP0002419_abnormal_innate_immunity0.87027388
135MP0009840_abnormal_foam_cell0.86423273
136MP0001533_abnormal_skeleton_physiology0.85703553
137MP0005025_abnormal_response_to0.84920235
138MP0001293_anophthalmia0.84837655
139MP0005379_endocrine/exocrine_gland_phen0.83624322
140MP0002160_abnormal_reproductive_system0.83239062
141MP0005367_renal/urinary_system_phenotyp0.83120486
142MP0000516_abnormal_urinary_system0.83120486
143MP0002928_abnormal_bile_duct0.81379401
144MP0003787_abnormal_imprinting0.81068820
145MP0001853_heart_inflammation0.80128974
146MP0004742_abnormal_vestibular_system0.80051030
147MP0001849_ear_inflammation0.79405719
148MP0009765_abnormal_xenobiotic_induced0.78997062
149MP0000015_abnormal_ear_pigmentation0.78627340
150MP0002722_abnormal_immune_system0.78078535
151MP0001145_abnormal_male_reproductive0.78058906
152MP0010368_abnormal_lymphatic_system0.77925418
153MP0004134_abnormal_chest_morphology0.77567523
154MP0005666_abnormal_adipose_tissue0.77489438
155MP0003724_increased_susceptibility_to0.77453972
156MP0001661_extended_life_span0.77395474
157MP0005395_other_phenotype0.77235701
158MP0002429_abnormal_blood_cell0.77054879
159MP0000428_abnormal_craniofacial_morphol0.77028760
160MP0001986_abnormal_taste_sensitivity0.76131750
161MP0005085_abnormal_gallbladder_physiolo0.76061462
162MP0002925_abnormal_cardiovascular_devel0.75907873
163MP0009785_altered_susceptibility_to0.75696079
164MP0005266_abnormal_metabolism0.75499975
165MP0003111_abnormal_nucleus_morphology0.74342576
166MP0002019_abnormal_tumor_incidence0.74210103
167MP0001784_abnormal_fluid_regulation0.74001503
168MP0004510_myositis0.73071981
169MP0002168_other_aberrant_phenotype0.72663396
170MP0005187_abnormal_penis_morphology0.72440375
171MP0002092_abnormal_eye_morphology0.72405902
172MP0001845_abnormal_inflammatory_respons0.72397113
173MP0008569_lethality_at_weaning0.72114651

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)3.90264113
2Abnormality of the fingertips (HP:0001211)3.76342394
3T lymphocytopenia (HP:0005403)3.57841462
4Abnormality of T cell number (HP:0011839)3.39067369
5Pancreatic cysts (HP:0001737)3.38118852
6Macroorchidism (HP:0000053)3.33884842
7Acute necrotizing encephalopathy (HP:0006965)3.30520451
8Methylmalonic acidemia (HP:0002912)3.30249251
9Increased CSF lactate (HP:0002490)3.18727564
10Mitochondrial inheritance (HP:0001427)3.10161268
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09632859
12Abnormality of alanine metabolism (HP:0010916)3.09632859
13Hyperalaninemia (HP:0003348)3.09632859
14IgG deficiency (HP:0004315)3.09167202
15Acute encephalopathy (HP:0006846)3.05570846
16Increased hepatocellular lipid droplets (HP:0006565)3.02231501
17Abnormal mitochondria in muscle tissue (HP:0008316)2.95354596
18Progressive macrocephaly (HP:0004481)2.93974888
19True hermaphroditism (HP:0010459)2.88764313
20Lipid accumulation in hepatocytes (HP:0006561)2.88420969
21Medial flaring of the eyebrow (HP:0010747)2.80528557
22Increased serum lactate (HP:0002151)2.77019724
23Pancreatic fibrosis (HP:0100732)2.75024803
24Renal cortical cysts (HP:0000803)2.71820519
25Trigonocephaly (HP:0000243)2.65364097
26Hypoproteinemia (HP:0003075)2.64691290
27Methylmalonic aciduria (HP:0012120)2.63586978
28Broad metatarsal (HP:0001783)2.60251031
29Abnormality of the renal cortex (HP:0011035)2.59343663
30Hepatocellular necrosis (HP:0001404)2.56753775
31Aortic aneurysm (HP:0004942)2.55433624
32Molar tooth sign on MRI (HP:0002419)2.53582637
33Abnormality of midbrain morphology (HP:0002418)2.53582637
34Recurrent viral infections (HP:0004429)2.52773247
35Hepatic necrosis (HP:0002605)2.47820223
36Narrow palate (HP:0000189)2.44941091
37Hematochezia (HP:0002573)2.42805717
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40267993
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40267993
40Shallow orbits (HP:0000586)2.40018850
41Type I transferrin isoform profile (HP:0003642)2.37744364
42Lactic acidosis (HP:0003128)2.36304217
43Meckel diverticulum (HP:0002245)2.36023748
44Combined immunodeficiency (HP:0005387)2.34011812
45Aplastic anemia (HP:0001915)2.33470467
46B lymphocytopenia (HP:0010976)2.29752624
47Abnormality of B cell number (HP:0010975)2.29752624
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29591684
49Abnormal protein N-linked glycosylation (HP:0012347)2.29591684
50Abnormal protein glycosylation (HP:0012346)2.29591684
51Abnormal glycosylation (HP:0012345)2.29591684
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29260084
53Short 4th metacarpal (HP:0010044)2.29260084
54Abnormality of the ileum (HP:0001549)2.28372100
55Hypothermia (HP:0002045)2.27375006
56Colon cancer (HP:0003003)2.26796316
57Disproportionate tall stature (HP:0001519)2.26291483
58Congenital stationary night blindness (HP:0007642)2.25811605
59Renal Fanconi syndrome (HP:0001994)2.24710662
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.21005440
61Persistence of primary teeth (HP:0006335)2.20149135
62Premature skin wrinkling (HP:0100678)2.18672935
63Mitral valve prolapse (HP:0001634)2.14482234
64Cerebral aneurysm (HP:0004944)2.14267175
65Congenital, generalized hypertrichosis (HP:0004540)2.13404468
66Abnormality of the preputium (HP:0100587)2.12919730
67Cerebral edema (HP:0002181)2.12918747
68Increased IgE level (HP:0003212)2.11926309
69Chronic otitis media (HP:0000389)2.10952357
70Osteolytic defects of the hand bones (HP:0009699)2.10600041
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.10600041
72Pancytopenia (HP:0001876)2.09027668
73Stomatitis (HP:0010280)2.08645754
74Panhypogammaglobulinemia (HP:0003139)2.08180630
75Arterial tortuosity (HP:0005116)2.07924740
76Colitis (HP:0002583)2.07890396
77Abnormality of chromosome stability (HP:0003220)2.07659424
78Recurrent fungal infections (HP:0002841)2.06779761
79Spontaneous hematomas (HP:0007420)2.06586486
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06287324
81Volvulus (HP:0002580)2.04876236
82Agammaglobulinemia (HP:0004432)2.03525798
83Milia (HP:0001056)2.03491557
84Abnormality of the vitamin B12 metabolism (HP:0004341)2.02311587
85Nephronophthisis (HP:0000090)2.02293761
86Aplasia/hypoplasia of the uterus (HP:0008684)2.01708533
87Hyperacusis (HP:0010780)2.01634027
88Optic disc pallor (HP:0000543)2.01250830
89Ureteral obstruction (HP:0006000)2.00497223
90Increased IgM level (HP:0003496)1.97896034
91Aortic dissection (HP:0002647)1.97771720
92Abnormality of vitamin B metabolism (HP:0004340)1.97492927
93Congenital primary aphakia (HP:0007707)1.95401874
94Thin bony cortex (HP:0002753)1.95216948
95Thyroiditis (HP:0100646)1.94494157
96Abnormality of the labia minora (HP:0012880)1.93201570
97Inflammation of the large intestine (HP:0002037)1.93092581
98Abolished electroretinogram (ERG) (HP:0000550)1.93001790
99Generalized aminoaciduria (HP:0002909)1.92166125
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91424419
101Dilatation of the ascending aorta (HP:0005111)1.91235622
102Hypoplasia of the fovea (HP:0007750)1.90768763
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.90768763
104Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90758388
105Abnormality of serum amino acid levels (HP:0003112)1.90752294
106Bile duct proliferation (HP:0001408)1.89705112
107Abnormal biliary tract physiology (HP:0012439)1.89705112
108Ulnar bowing (HP:0003031)1.89217117
109Abnormality of the renal medulla (HP:0100957)1.88742398
110Broad ribs (HP:0000885)1.88574293
111Limited elbow extension (HP:0001377)1.88446601
112Myocardial infarction (HP:0001658)1.88216268
113Plagiocephaly (HP:0001357)1.88185103
114Vascular tortuosity (HP:0004948)1.87887898
115Aqueductal stenosis (HP:0002410)1.87430121
116Ureteral stenosis (HP:0000071)1.86978738
117Nephrogenic diabetes insipidus (HP:0009806)1.86932977
118Atrophic scars (HP:0001075)1.86676271
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.86129655
120Abnormality of oral frenula (HP:0000190)1.85590528
121Attenuation of retinal blood vessels (HP:0007843)1.84086112
122Oral leukoplakia (HP:0002745)1.83766663
123Papilloma (HP:0012740)1.83699732
124Verrucae (HP:0200043)1.83699732
125Sclerocornea (HP:0000647)1.83082167
126Tongue fasciculations (HP:0001308)1.82602284
127Recurrent bronchitis (HP:0002837)1.82520181
128Spondylolisthesis (HP:0003302)1.81518266
129Abnormality of the pons (HP:0007361)1.81495165
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.80088836
131Gastrointestinal inflammation (HP:0004386)1.78974344
132Exertional dyspnea (HP:0002875)1.78902818
133Hemiplegia (HP:0002301)1.78738931
134Increased density of long bones (HP:0006392)1.78322538
135Lethargy (HP:0001254)1.78257126
136Gait imbalance (HP:0002141)1.78104808
137Increased intramyocellular lipid droplets (HP:0012240)1.77345015
138Increased corneal curvature (HP:0100692)1.76449412
139Keratoconus (HP:0000563)1.76449412
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75820420
141Sparse eyelashes (HP:0000653)1.75674786
142Transitional cell carcinoma of the bladder (HP:0006740)1.75431294
143Clubbing of toes (HP:0100760)1.75389894
144Autoimmune hemolytic anemia (HP:0001890)1.74232731
145Abnormality of methionine metabolism (HP:0010901)1.74022775
146Erythroderma (HP:0001019)1.73810403
147Neutropenia (HP:0001875)1.72765978
1482-3 toe syndactyly (HP:0004691)1.72744102
149Abnormality of the 4th metacarpal (HP:0010012)1.71901653
150Eosinophilia (HP:0001880)1.71828730
151Mitral regurgitation (HP:0001653)1.71531962
152Abnormality of T cells (HP:0002843)1.70994413
153Heterotopia (HP:0002282)1.70117612
154Abnormality of T cell physiology (HP:0011840)1.69361204
155Fatigue (HP:0012378)1.68980750
156Respiratory failure (HP:0002878)1.66955930
157Anteriorly placed anus (HP:0001545)1.65732596
158Abnormal rod and cone electroretinograms (HP:0008323)1.65697039
159Aneurysm (HP:0002617)1.65518899
160Autoimmune thrombocytopenia (HP:0001973)1.64138911
161Obsessive-compulsive behavior (HP:0000722)1.63500954
162Genetic anticipation (HP:0003743)1.63219731
163Bladder neoplasm (HP:0009725)1.62711539
164Bladder carcinoma (HP:0002862)1.62711539
165Subacute progressive viral hepatitis (HP:0006572)1.62467673
166Epiphyseal dysplasia (HP:0002656)1.62131081
167Exostoses (HP:0100777)1.61828651
168Chronic mucocutaneous candidiasis (HP:0002728)1.61647172
169Recurrent cutaneous fungal infections (HP:0011370)1.61647172
170Severe combined immunodeficiency (HP:0004430)1.60888554
171Premature rupture of membranes (HP:0001788)1.58441924
172Vitreoretinal degeneration (HP:0000655)1.57826194
173Eczematoid dermatitis (HP:0000976)1.57551389
174Rectal prolapse (HP:0002035)1.56436016
175Abnormal foot bone ossification (HP:0010675)1.55647536
176Mitral stenosis (HP:0001718)1.55430372
177Hyporeflexia of lower limbs (HP:0002600)1.53450029
178Bladder diverticulum (HP:0000015)1.52792682
179Thick nail (HP:0001805)1.51003304
180Neoplasm of the heart (HP:0100544)1.50539608
181Cellulitis (HP:0100658)1.50413077
182Viral hepatitis (HP:0006562)1.47734418
183Emphysema (HP:0002097)1.47598386
184Long eyelashes (HP:0000527)1.47416155
185Deviation of the hallux (HP:0010051)1.46788761
186Abnormality of eosinophils (HP:0001879)1.46630119
187Increased CSF protein (HP:0002922)1.46510498
188Chorioretinal atrophy (HP:0000533)1.46317823
189Thickened helices (HP:0000391)1.46218051
190Hallux valgus (HP:0001822)1.46131418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.79965046
2FGFR22.85564241
3ZAK2.74209107
4EIF2AK32.68454658
5VRK22.68180542
6BMPR1B2.66855388
7MAP3K102.59913095
8TRIM282.57986825
9EPHB12.54463071
10STK162.51663673
11MAP4K22.33096476
12FGFR42.24381266
13TLK12.23493889
14WNK32.20590036
15SIK12.13904880
16MAP3K122.08349885
17MAP4K12.06445116
18FGFR32.02842396
19VRK12.02448074
20TRIB31.97229621
21ACVR1B1.97060132
22ITK1.95071542
23GRK11.94997586
24BCR1.92255605
25EEF2K1.90523113
26PTK61.87978991
27MAP3K141.86314452
28CAMK1G1.82793810
29CDK61.78943450
30SRPK11.72128035
31ADRBK21.71281493
32TESK21.68127033
33RIPK11.67836801
34EPHA31.67259526
35CDK121.60990530
36ERN11.59497307
37INSRR1.58134170
38BRD41.57909108
39BRSK21.55894764
40JAK11.55573457
41BUB11.51329376
42LRRK21.50040496
43STK101.46383758
44EIF2AK11.44729991
45SIK21.42645937
46PDGFRA1.42091296
47CAMK1D1.42065078
48WNK11.39757754
49TYK21.39543195
50TNIK1.39112979
51PKN21.38823146
52PLK31.37719402
53ERBB31.37560945
54MARK21.31753766
55TSSK61.30696686
56PDGFRB1.28798789
57TXK1.25714227
58TYRO31.24282644
59NEK11.23965775
60TTN1.22760840
61LATS11.22598494
62JAK31.21486886
63CSK1.20961680
64PDK21.19638481
65MAP3K71.19414136
66BCKDK1.19327009
67CDK91.19034563
68FRK1.18648914
69MKNK21.18628558
70HIPK21.15963042
71CSNK1A1L1.11040546
72RET1.09836413
73TGFBR11.09159653
74DDR21.07813731
75PRKCH1.02393129
76SIK31.01008334
77ZAP700.99983554
78NUAK10.98449578
79FGFR10.97607287
80MAPKAPK30.96491487
81CSNK1G30.94450708
82MTOR0.94393394
83HCK0.92393867
84PLK40.92090727
85GRK70.90442212
86ALK0.89902296
87TAOK10.89550641
88DMPK0.87593873
89OXSR10.86188972
90MKNK10.85941696
91DYRK1B0.83192189
92LCK0.82980962
93CCNB10.82133410
94BMX0.81814754
95PKN10.81574754
96JAK20.81392424
97TAOK30.80789482
98TGFBR20.80032012
99NME10.79785679
100PRKCQ0.79517441
101PLK20.79338445
102PRKD20.78625273
103IKBKE0.76596298
104BTK0.76352722
105STK30.75771417
106NLK0.75493510
107TAF10.75158256
108TIE10.74816749
109CAMKK20.74712100
110TEC0.74067407
111CHUK0.72936175
112PASK0.72112127
113PRKD10.72089790
114WEE10.71654073
115SGK30.71415208
116WNK40.71090143
117MAP3K130.70433196
118STK240.69960214
119MAP3K60.68749540
120CDK40.68137932
121STK38L0.68040481
122PRKAA20.66148770
123PAK20.65666135
124GRK60.65514138
125EIF2AK20.63820742
126PLK10.63437045
127PINK10.62639232
128CDC42BPA0.62016189
129STK390.61690887
130KDR0.61558397
131FLT30.61386615
132ROCK20.60580836
133PTK20.59993365
134CLK10.57856733
135PRKCE0.57702839
136GSK3A0.57552224
137ADRBK10.57532347
138TBK10.56653214
139FYN0.56576032
140NTRK20.55445810
141ICK0.54547749
142TRPM70.54331042
143CDK80.53794469
144PIK3CG0.53626799
145PBK0.53558035
146ERBB20.53537309
147MAP3K40.52488370
148STK110.52045029
149MYLK0.50737628
150ATR0.49768151
151PAK30.49672908
152UHMK10.49475225
153STK40.48121735
154CSNK1D0.47661545
155RPS6KA50.46594400
156MAP3K20.46237574
157MARK30.46151093
158TTK0.45917551
159CSNK1G20.45400797
160INSR0.45285602
161IKBKB0.45224408
162MAPK130.45125250
163CSNK1G10.45103735
164ABL10.44518296
165MAP3K30.43619345
166PRKCI0.43360980
167EGFR0.41867776
168CSNK2A10.41232333
169KIT0.39489503
170LIMK10.38477812
171MUSK0.36316131
172IGF1R0.34101461
173MAP2K70.32747545
174DYRK20.31747703
175AURKB0.31745019
176ATM0.31504902
177PRKCG0.30875465
178BRSK10.29024297
179DAPK10.28896800
180FER0.28857729
181LYN0.28506522

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.17165874
2Protein export_Homo sapiens_hsa030603.66213024
3Oxidative phosphorylation_Homo sapiens_hsa001902.84829178
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68767941
5RNA polymerase_Homo sapiens_hsa030202.56740221
6Homologous recombination_Homo sapiens_hsa034402.41697521
7Non-homologous end-joining_Homo sapiens_hsa034502.37702961
8Parkinsons disease_Homo sapiens_hsa050122.30300440
9Fanconi anemia pathway_Homo sapiens_hsa034602.23605946
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20895753
11Mismatch repair_Homo sapiens_hsa034302.18395956
12Basal transcription factors_Homo sapiens_hsa030222.16290382
13Primary immunodeficiency_Homo sapiens_hsa053402.05708584
14Propanoate metabolism_Homo sapiens_hsa006402.02586852
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87317014
16RNA degradation_Homo sapiens_hsa030181.86475282
17T cell receptor signaling pathway_Homo sapiens_hsa046601.80220186
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74747641
19Lysine degradation_Homo sapiens_hsa003101.68994485
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67184790
21Chronic myeloid leukemia_Homo sapiens_hsa052201.63429415
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61331327
23Nucleotide excision repair_Homo sapiens_hsa034201.60769406
24Nitrogen metabolism_Homo sapiens_hsa009101.60660732
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.56077275
26B cell receptor signaling pathway_Homo sapiens_hsa046621.52534410
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49711207
28Huntingtons disease_Homo sapiens_hsa050161.48196098
29RNA transport_Homo sapiens_hsa030131.46031107
30Osteoclast differentiation_Homo sapiens_hsa043801.44953644
31One carbon pool by folate_Homo sapiens_hsa006701.44224161
32Phototransduction_Homo sapiens_hsa047441.44110795
33Toxoplasmosis_Homo sapiens_hsa051451.42473835
34Ribosome_Homo sapiens_hsa030101.40861061
35DNA replication_Homo sapiens_hsa030301.39712238
36Pancreatic cancer_Homo sapiens_hsa052121.38539263
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.36994999
38Pyrimidine metabolism_Homo sapiens_hsa002401.35554021
39Small cell lung cancer_Homo sapiens_hsa052221.34585896
40Viral myocarditis_Homo sapiens_hsa054161.32474111
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31015802
42Selenocompound metabolism_Homo sapiens_hsa004501.29566135
43Alzheimers disease_Homo sapiens_hsa050101.29235051
44Focal adhesion_Homo sapiens_hsa045101.29023896
45ECM-receptor interaction_Homo sapiens_hsa045121.28789874
46Proteoglycans in cancer_Homo sapiens_hsa052051.23893161
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22852698
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20833485
49Adherens junction_Homo sapiens_hsa045201.20772339
50Base excision repair_Homo sapiens_hsa034101.19819836
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18901437
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18729353
53Spliceosome_Homo sapiens_hsa030401.18004444
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17734461
55Insulin resistance_Homo sapiens_hsa049311.16612093
56Leishmaniasis_Homo sapiens_hsa051401.15563057
57Measles_Homo sapiens_hsa051621.13345294
58Renal cell carcinoma_Homo sapiens_hsa052111.13064136
59Notch signaling pathway_Homo sapiens_hsa043301.11675797
60MicroRNAs in cancer_Homo sapiens_hsa052061.09646909
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.08998084
62Butanoate metabolism_Homo sapiens_hsa006501.07494062
63Chemokine signaling pathway_Homo sapiens_hsa040621.07440661
64Purine metabolism_Homo sapiens_hsa002301.06850503
65Autoimmune thyroid disease_Homo sapiens_hsa053201.05909918
66Type I diabetes mellitus_Homo sapiens_hsa049401.05826258
67Adipocytokine signaling pathway_Homo sapiens_hsa049201.05780113
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05427376
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04672507
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.04563251
71Platelet activation_Homo sapiens_hsa046111.04535910
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03144991
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02856455
74Collecting duct acid secretion_Homo sapiens_hsa049661.02648453
75Prostate cancer_Homo sapiens_hsa052151.01173526
76Peroxisome_Homo sapiens_hsa041460.99848078
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99731307
78Regulation of autophagy_Homo sapiens_hsa041400.99463330
79TNF signaling pathway_Homo sapiens_hsa046680.99173612
80Hematopoietic cell lineage_Homo sapiens_hsa046400.99070568
81Non-small cell lung cancer_Homo sapiens_hsa052230.98898546
82Rheumatoid arthritis_Homo sapiens_hsa053230.98766315
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.98152695
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.97673503
85Hepatitis B_Homo sapiens_hsa051610.96817852
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95693081
87Linoleic acid metabolism_Homo sapiens_hsa005910.95416785
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94447788
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94088031
90Dorso-ventral axis formation_Homo sapiens_hsa043200.93574503
91Hepatitis C_Homo sapiens_hsa051600.92455005
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92176228
93Type II diabetes mellitus_Homo sapiens_hsa049300.92075880
94VEGF signaling pathway_Homo sapiens_hsa043700.91323221
95p53 signaling pathway_Homo sapiens_hsa041150.91054218
96Malaria_Homo sapiens_hsa051440.89899275
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89624815
98Steroid biosynthesis_Homo sapiens_hsa001000.88761800
99Sulfur metabolism_Homo sapiens_hsa009200.88615809
100Glioma_Homo sapiens_hsa052140.87710569
101mTOR signaling pathway_Homo sapiens_hsa041500.87296973
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87130947
103Acute myeloid leukemia_Homo sapiens_hsa052210.87078492
104Tryptophan metabolism_Homo sapiens_hsa003800.85308059
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85119088
106Fatty acid elongation_Homo sapiens_hsa000620.83454501
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82382889
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.81997624
109Amoebiasis_Homo sapiens_hsa051460.81744408
110Choline metabolism in cancer_Homo sapiens_hsa052310.80765929
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.80668375
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80466364
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80290274
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80061003
115Colorectal cancer_Homo sapiens_hsa052100.80046157
116Caffeine metabolism_Homo sapiens_hsa002320.80040758
117FoxO signaling pathway_Homo sapiens_hsa040680.79752760
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79364923
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78350149
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77630502
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.77556364
122Antigen processing and presentation_Homo sapiens_hsa046120.77271345
123Shigellosis_Homo sapiens_hsa051310.76057925
124ABC transporters_Homo sapiens_hsa020100.75872711
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75678744
126ErbB signaling pathway_Homo sapiens_hsa040120.75327089
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75022096
128Endometrial cancer_Homo sapiens_hsa052130.74782789
129MAPK signaling pathway_Homo sapiens_hsa040100.74641987
130HTLV-I infection_Homo sapiens_hsa051660.74406892
131Asthma_Homo sapiens_hsa053100.74344275
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73714813
133Apoptosis_Homo sapiens_hsa042100.72933106
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72304455
135Endocytosis_Homo sapiens_hsa041440.71685374
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71243656
137Prolactin signaling pathway_Homo sapiens_hsa049170.71003996
138Circadian rhythm_Homo sapiens_hsa047100.70580401
139Protein digestion and absorption_Homo sapiens_hsa049740.70384615
140Glutathione metabolism_Homo sapiens_hsa004800.68791592
141Graft-versus-host disease_Homo sapiens_hsa053320.67749823
142Tuberculosis_Homo sapiens_hsa051520.67120705
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66360276
144Axon guidance_Homo sapiens_hsa043600.66068264
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65214086
146Rap1 signaling pathway_Homo sapiens_hsa040150.64683647
147Metabolic pathways_Homo sapiens_hsa011000.64396626
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64247264
149Influenza A_Homo sapiens_hsa051640.64099362
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63558911
151Legionellosis_Homo sapiens_hsa051340.63229737
152Pathways in cancer_Homo sapiens_hsa052000.63178087
153Gastric acid secretion_Homo sapiens_hsa049710.63068898
154Inositol phosphate metabolism_Homo sapiens_hsa005620.62345082
155Pancreatic secretion_Homo sapiens_hsa049720.62281772
156AMPK signaling pathway_Homo sapiens_hsa041520.61423033
157Allograft rejection_Homo sapiens_hsa053300.59559806
158Dilated cardiomyopathy_Homo sapiens_hsa054140.58792625
159Chemical carcinogenesis_Homo sapiens_hsa052040.58160302
160Viral carcinogenesis_Homo sapiens_hsa052030.57606987
161Herpes simplex infection_Homo sapiens_hsa051680.56529129
162Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55359736
163Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54849625
164Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54668029
165Fatty acid biosynthesis_Homo sapiens_hsa000610.54530524
166PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54505683
167Ether lipid metabolism_Homo sapiens_hsa005650.53418718
168Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53348935
169Cell cycle_Homo sapiens_hsa041100.51373953
170Drug metabolism - other enzymes_Homo sapiens_hsa009830.49134678
171Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46624862
172Pyruvate metabolism_Homo sapiens_hsa006200.45832612
173Folate biosynthesis_Homo sapiens_hsa007900.45199184
174Maturity onset diabetes of the young_Homo sapiens_hsa049500.44602261
175Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42961752
176Arachidonic acid metabolism_Homo sapiens_hsa005900.40314396
177Steroid hormone biosynthesis_Homo sapiens_hsa001400.38722095
178Epstein-Barr virus infection_Homo sapiens_hsa051690.38574371
179Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37762292
180Cardiac muscle contraction_Homo sapiens_hsa042600.37614497
181Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37557559
182Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36598537
183Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34788300

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