DUSP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.28927406
2purine nucleobase biosynthetic process (GO:0009113)4.85647976
3ribosome assembly (GO:0042255)4.82558724
4mitotic metaphase plate congression (GO:0007080)4.78210239
5proteasome assembly (GO:0043248)4.70787360
6nucleobase biosynthetic process (GO:0046112)4.60438763
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.29504650
8folic acid metabolic process (GO:0046655)4.28494422
9ribosome biogenesis (GO:0042254)4.23032663
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.20965359
11chaperone-mediated protein transport (GO:0072321)4.16652284
12DNA replication checkpoint (GO:0000076)4.15578757
13respiratory chain complex IV assembly (GO:0008535)4.12234524
14maturation of 5.8S rRNA (GO:0000460)4.04356948
15DNA replication initiation (GO:0006270)4.04328691
16rRNA modification (GO:0000154)4.04082236
17metaphase plate congression (GO:0051310)4.03068381
18DNA damage response, detection of DNA damage (GO:0042769)3.99556385
19DNA double-strand break processing (GO:0000729)3.95750721
20protein complex biogenesis (GO:0070271)3.93520575
21cullin deneddylation (GO:0010388)3.93510104
22folic acid-containing compound biosynthetic process (GO:0009396)3.90884417
23CENP-A containing nucleosome assembly (GO:0034080)3.90512484
24DNA strand elongation involved in DNA replication (GO:0006271)3.83194627
25maturation of SSU-rRNA (GO:0030490)3.82468692
26mitochondrial respiratory chain complex assembly (GO:0033108)3.82329385
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77305586
28ribosomal large subunit biogenesis (GO:0042273)3.75686515
29chromatin remodeling at centromere (GO:0031055)3.74122844
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.73055446
31formation of translation preinitiation complex (GO:0001731)3.72798618
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72409379
33ATP synthesis coupled proton transport (GO:0015986)3.72409379
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72048060
35ribonucleoprotein complex biogenesis (GO:0022613)3.71258258
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.70188378
37DNA strand elongation (GO:0022616)3.69528783
38NADH dehydrogenase complex assembly (GO:0010257)3.68997448
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68997448
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.68997448
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.67957264
42termination of RNA polymerase III transcription (GO:0006386)3.67957264
43cytochrome complex assembly (GO:0017004)3.67580207
44regulation of mitochondrial translation (GO:0070129)3.62764119
45attachment of spindle microtubules to kinetochore (GO:0008608)3.59625129
46mitotic nuclear envelope disassembly (GO:0007077)3.59557661
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57727562
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57012700
49protein localization to kinetochore (GO:0034501)3.54869965
50rRNA processing (GO:0006364)3.53455932
51protein K6-linked ubiquitination (GO:0085020)3.53084360
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52381796
53telomere maintenance via semi-conservative replication (GO:0032201)3.52184479
54regulation of spindle organization (GO:0090224)3.50921136
55ribosomal small subunit assembly (GO:0000028)3.50701414
56DNA replication-independent nucleosome organization (GO:0034724)3.49998590
57DNA replication-independent nucleosome assembly (GO:0006336)3.49998590
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.47325559
59establishment of chromosome localization (GO:0051303)3.44368918
60spliceosomal snRNP assembly (GO:0000387)3.43836784
61regulation of cellular amino acid metabolic process (GO:0006521)3.43078582
62rRNA metabolic process (GO:0016072)3.42041267
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41935606
647-methylguanosine mRNA capping (GO:0006370)3.40575332
65pseudouridine synthesis (GO:0001522)3.39614867
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35437323
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35310143
68respiratory electron transport chain (GO:0022904)3.35272300
69DNA replication-dependent nucleosome assembly (GO:0006335)3.34217519
70DNA replication-dependent nucleosome organization (GO:0034723)3.34217519
71nuclear envelope disassembly (GO:0051081)3.33824474
72membrane disassembly (GO:0030397)3.33824474
73regulation of double-strand break repair via homologous recombination (GO:0010569)3.33420128
74rRNA methylation (GO:0031167)3.32897809
75negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32498733
76histone-serine phosphorylation (GO:0035404)3.31796550
77replication fork processing (GO:0031297)3.31434119
78RNA capping (GO:0036260)3.30807807
797-methylguanosine RNA capping (GO:0009452)3.30807807
80amino acid salvage (GO:0043102)3.30370759
81L-methionine salvage (GO:0071267)3.30370759
82L-methionine biosynthetic process (GO:0071265)3.30370759
83electron transport chain (GO:0022900)3.29944758
84protein deneddylation (GO:0000338)3.29299877
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28743910
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28743910
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28743910
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28167126
89negative regulation of sister chromatid segregation (GO:0033046)3.28167126
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.28167126
91negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28167126
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27768511
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27768511
94protein targeting to mitochondrion (GO:0006626)3.27577256
95negative regulation of chromosome segregation (GO:0051985)3.26351909
96spindle checkpoint (GO:0031577)3.24753024
97telomere maintenance via recombination (GO:0000722)3.22348530
98histone exchange (GO:0043486)3.22130661
99termination of RNA polymerase I transcription (GO:0006363)3.21533769
100mitotic spindle assembly checkpoint (GO:0007094)3.20904614
101transcription from RNA polymerase I promoter (GO:0006360)3.20657182
102signal transduction involved in cell cycle checkpoint (GO:0072395)3.20328082
103protein localization to chromosome, centromeric region (GO:0071459)3.19310524
104protein-cofactor linkage (GO:0018065)3.18879086
105DNA catabolic process, exonucleolytic (GO:0000738)3.18411418
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15641899
107protein localization to mitochondrion (GO:0070585)3.15269967
108signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15263187
109signal transduction involved in DNA damage checkpoint (GO:0072422)3.15263187
110regulation of nuclear cell cycle DNA replication (GO:0033262)3.14693989
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14322868
112RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14322868
113spindle assembly checkpoint (GO:0071173)3.14288229
114transcription-coupled nucleotide-excision repair (GO:0006283)3.14133220
115mitotic spindle checkpoint (GO:0071174)3.13378603
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13319371
117negative regulation of ligase activity (GO:0051352)3.13319371
118protein neddylation (GO:0045116)3.12746522
119kinetochore assembly (GO:0051382)3.09994170
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09464422
121establishment of integrated proviral latency (GO:0075713)3.08609544
122transcription elongation from RNA polymerase I promoter (GO:0006362)3.08451505
123peptidyl-histidine modification (GO:0018202)3.07640425
124G1/S transition of mitotic cell cycle (GO:0000082)3.06820601
125cell cycle G1/S phase transition (GO:0044843)3.06820601
126IMP biosynthetic process (GO:0006188)3.06093304
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05331379
128base-excision repair, AP site formation (GO:0006285)3.05257782
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05226345
130establishment of protein localization to mitochondrion (GO:0072655)3.05172851
131telomere maintenance via telomere lengthening (GO:0010833)3.04693146
132translational initiation (GO:0006413)3.04455673
133cellular component biogenesis (GO:0044085)3.03827876
134regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01267847
135histone mRNA metabolic process (GO:0008334)3.01171148
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99784466
137regulation of mitotic spindle checkpoint (GO:1903504)2.99784466
138positive regulation of ligase activity (GO:0051351)2.99240726
139regulation of chromosome segregation (GO:0051983)2.97060002
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.96375952
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96375952
142mitotic sister chromatid segregation (GO:0000070)2.96328803
143mitotic recombination (GO:0006312)2.96310420
144kinetochore organization (GO:0051383)2.94807604
145IMP metabolic process (GO:0046040)2.93991609
146mannosylation (GO:0097502)2.93783153
147regulation of translation in response to stress (GO:0043555)2.92828788
148pteridine-containing compound biosynthetic process (GO:0042559)2.90904145
149methionine biosynthetic process (GO:0009086)2.89910032
150mitochondrial RNA metabolic process (GO:0000959)2.89812372
151regulation of ubiquitin-protein transferase activity (GO:0051438)2.87582077
152metallo-sulfur cluster assembly (GO:0031163)2.85581286
153iron-sulfur cluster assembly (GO:0016226)2.85581286
154histone H2A acetylation (GO:0043968)2.81622060
155negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.79808028
156centriole replication (GO:0007099)2.78929705
157platelet dense granule organization (GO:0060155)2.78280735
158regulation of ligase activity (GO:0051340)2.72335089
159nucleotide-excision repair, DNA gap filling (GO:0006297)2.72296872
160tRNA processing (GO:0008033)2.70485007
161RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70470434
162DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.70010070
163water-soluble vitamin biosynthetic process (GO:0042364)2.69859562
164resolution of meiotic recombination intermediates (GO:0000712)2.67972398
165DNA ligation (GO:0006266)2.66665555
166synapsis (GO:0007129)2.66391111
167pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65674080
168maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65118077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70281289
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.49459873
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69045569
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61367717
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54773771
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.39870697
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.26896058
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.25567802
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.17947815
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09583072
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07376107
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00320199
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97837156
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96962519
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89029884
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79993904
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62450902
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50485001
19VDR_23849224_ChIP-Seq_CD4+_Human2.48810380
20ZNF274_21170338_ChIP-Seq_K562_Hela2.46515222
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42713349
22XRN2_22483619_ChIP-Seq_HELA_Human2.38666049
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32756135
24GABP_19822575_ChIP-Seq_HepG2_Human2.32326445
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24917880
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17859273
27DCP1A_22483619_ChIP-Seq_HELA_Human2.16194089
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15637676
29FOXP3_21729870_ChIP-Seq_TREG_Human2.11088827
30AR_21909140_ChIP-Seq_LNCAP_Human2.07941479
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06077074
32NANOG_18555785_ChIP-Seq_MESCs_Mouse2.04566411
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97038940
34TTF2_22483619_ChIP-Seq_HELA_Human1.86425331
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85477844
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83656288
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83514707
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82252144
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80618602
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79365505
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.79207119
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.77500051
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77189839
44* SRF_21415370_ChIP-Seq_HL-1_Mouse1.73303193
45EWS_26573619_Chip-Seq_HEK293_Human1.70716005
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69199378
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65677049
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62030284
49VDR_22108803_ChIP-Seq_LS180_Human1.61069443
50FUS_26573619_Chip-Seq_HEK293_Human1.56672424
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54868716
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52620037
53ELK1_19687146_ChIP-ChIP_HELA_Human1.51446288
54* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51157912
55CIITA_25753668_ChIP-Seq_RAJI_Human1.48861929
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.47684433
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.46464623
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46135396
59* SALL1_21062744_ChIP-ChIP_HESCs_Human1.45187483
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44291831
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43681316
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42007065
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40901291
64IGF1R_20145208_ChIP-Seq_DFB_Human1.38806111
65IRF1_19129219_ChIP-ChIP_H3396_Human1.37010819
66* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35025231
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34660387
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29449439
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28320837
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27704719
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27548022
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22632229
73MYC_18940864_ChIP-ChIP_HL60_Human1.21511775
74MYC_22102868_ChIP-Seq_BL_Human1.20818469
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17431452
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17227168
77* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17211983
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16287251
79TP53_22573176_ChIP-Seq_HFKS_Human1.14868318
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14749591
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.14742388
82TFEB_21752829_ChIP-Seq_HELA_Human1.12333713
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.11964576
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09602406
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09343427
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09294185
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08470003
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03670633
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03273837
90P300_19829295_ChIP-Seq_ESCs_Human1.03273212
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03111533
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02657114
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01958554
94TAF15_26573619_Chip-Seq_HEK293_Human1.01705869
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.01582747
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01462988
97* SOX2_16153702_ChIP-ChIP_HESCs_Human1.01363639
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00676001
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98891821
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98614815
101* NANOG_16153702_ChIP-ChIP_HESCs_Human0.96014328
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95271990
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95223604
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93777497
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93741030
106CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92764042
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92609825
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91912865
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91383604
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.89793108
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89215978
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89019057
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88760832
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87530888
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.86655310
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85692336
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85338120
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84297255
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83473708
120SPI1_23547873_ChIP-Seq_NB4_Human0.83279478
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83165503
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82982418
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82570177
124* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82349916
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81898726
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80319644
127* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79535006
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79058068
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78848224
130* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78289541
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78187432
132CBP_20019798_ChIP-Seq_JUKART_Human0.78187432
133* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77143299

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.56281441
2MP0004957_abnormal_blastocyst_morpholog4.78086549
3MP0003111_abnormal_nucleus_morphology4.63941562
4MP0010094_abnormal_chromosome_stability4.51523921
5MP0003077_abnormal_cell_cycle4.05023192
6MP0003718_maternal_effect4.01460467
7MP0008058_abnormal_DNA_repair3.32447371
8MP0008007_abnormal_cellular_replicative3.05591009
9MP0003123_paternal_imprinting2.80422497
10MP0008932_abnormal_embryonic_tissue2.80389502
11MP0000372_irregular_coat_pigmentation2.76498956
12MP0001529_abnormal_vocalization2.68785043
13MP0008789_abnormal_olfactory_epithelium2.40402939
14MP0003806_abnormal_nucleotide_metabolis2.20570647
15MP0001730_embryonic_growth_arrest2.14163221
16MP0008057_abnormal_DNA_replication2.12963625
17MP0003786_premature_aging2.09277998
18MP0008995_early_reproductive_senescence2.00824379
19MP0005394_taste/olfaction_phenotype1.99360379
20MP0005499_abnormal_olfactory_system1.99360379
21MP0000350_abnormal_cell_proliferation1.96983732
22MP0006072_abnormal_retinal_apoptosis1.94939001
23MP0002938_white_spotting1.93172533
24MP0002396_abnormal_hematopoietic_system1.91263646
25MP0003787_abnormal_imprinting1.89270185
26MP0003136_yellow_coat_color1.85541262
27MP0008877_abnormal_DNA_methylation1.80299815
28MP0000490_abnormal_crypts_of1.79452481
29MP0003646_muscle_fatigue1.73240590
30MP0003880_abnormal_central_pattern1.72743905
31MP0002736_abnormal_nociception_after1.72530976
32MP0001697_abnormal_embryo_size1.66824118
33MP0006292_abnormal_olfactory_placode1.66203483
34MP0001672_abnormal_embryogenesis/_devel1.64541576
35MP0005380_embryogenesis_phenotype1.64541576
36MP0008260_abnormal_autophagy1.61367944
37MP0002080_prenatal_lethality1.56062253
38MP0009333_abnormal_splenocyte_physiolog1.54712055
39MP0006276_abnormal_autonomic_nervous1.52847213
40MP0002638_abnormal_pupillary_reflex1.51801223
41MP0001119_abnormal_female_reproductive1.51233512
42MP0002751_abnormal_autonomic_nervous1.50833095
43MP0002102_abnormal_ear_morphology1.49918685
44MP0003315_abnormal_perineum_morphology1.49377810
45MP0002210_abnormal_sex_determination1.46576682
46MP0002085_abnormal_embryonic_tissue1.46274172
47MP0005395_other_phenotype1.45692042
48MP0005253_abnormal_eye_physiology1.45230946
49MP0002234_abnormal_pharynx_morphology1.44344264
50MP0003567_abnormal_fetal_cardiomyocyte1.42892208
51MP0009840_abnormal_foam_cell1.42543761
52MP0009046_muscle_twitch1.38607039
53MP0003984_embryonic_growth_retardation1.38385781
54MP0001984_abnormal_olfaction1.37623971
55MP0005451_abnormal_body_composition1.37490345
56MP0002160_abnormal_reproductive_system1.37424097
57MP0003186_abnormal_redox_activity1.34717071
58MP0002088_abnormal_embryonic_growth/wei1.34185747
59MP0005389_reproductive_system_phenotype1.34052734
60MP0000313_abnormal_cell_death1.32900604
61MP0000653_abnormal_sex_gland1.32474343
62MP0002019_abnormal_tumor_incidence1.32175007
63MP0001919_abnormal_reproductive_system1.29738097
64MP0002132_abnormal_respiratory_system1.29585653
65MP0003122_maternal_imprinting1.27685136
66MP0005551_abnormal_eye_electrophysiolog1.26515642
67MP0001145_abnormal_male_reproductive1.25113447
68MP0001968_abnormal_touch/_nociception1.24632380
69MP0002163_abnormal_gland_morphology1.23587296
70MP0004808_abnormal_hematopoietic_stem1.22652649
71MP0001545_abnormal_hematopoietic_system1.22527815
72MP0005397_hematopoietic_system_phenotyp1.22527815
73MP0003699_abnormal_female_reproductive1.20728245
74MP0002735_abnormal_chemical_nociception1.18507046
75MP0000631_abnormal_neuroendocrine_gland1.18472741
76MP0001929_abnormal_gametogenesis1.18352137
77MP0002233_abnormal_nose_morphology1.17960450
78MP0002086_abnormal_extraembryonic_tissu1.17611051
79MP0002822_catalepsy1.17169498
80MP0002084_abnormal_developmental_patter1.17040601
81MP0004147_increased_porphyrin_level1.16710344
82MP0003890_abnormal_embryonic-extraembry1.15795515
83MP0006036_abnormal_mitochondrial_physio1.15158501
84MP0000516_abnormal_urinary_system1.14119298
85MP0005367_renal/urinary_system_phenotyp1.14119298
86MP0009697_abnormal_copulation1.11632960
87MP0010307_abnormal_tumor_latency1.10852783
88MP0000647_abnormal_sebaceous_gland1.09118287
89MP0004142_abnormal_muscle_tone1.07710550
90MP0000358_abnormal_cell_content/1.06105589
91MP0005379_endocrine/exocrine_gland_phen1.06038058
92MP0002653_abnormal_ependyma_morphology1.04690018
93MP0000049_abnormal_middle_ear1.03600258
94MP0009379_abnormal_foot_pigmentation0.99755643
95MP0003656_abnormal_erythrocyte_physiolo0.97327742
96MP0001286_abnormal_eye_development0.96165872
97MP0001764_abnormal_homeostasis0.93713183
98MP0003195_calcinosis0.92098703
99MP0005645_abnormal_hypothalamus_physiol0.90827894
100MP0008872_abnormal_physiological_respon0.90763326
101MP0003698_abnormal_male_reproductive0.90528634
102MP0005391_vision/eye_phenotype0.89714029
103MP0001905_abnormal_dopamine_level0.88910191
104MP0002090_abnormal_vision0.88873181
105MP0000689_abnormal_spleen_morphology0.87409619
106MP0000778_abnormal_nervous_system0.86983047
107MP0002277_abnormal_respiratory_mucosa0.86872400
108MP0003121_genomic_imprinting0.86520751
109MP0003763_abnormal_thymus_physiology0.84914290
110MP0006035_abnormal_mitochondrial_morpho0.84222473
111MP0004197_abnormal_fetal_growth/weight/0.83538843
112MP0001324_abnormal_eye_pigmentation0.83521991
113MP0003943_abnormal_hepatobiliary_system0.82713957
114MP0002837_dystrophic_cardiac_calcinosis0.82703933
115MP0003755_abnormal_palate_morphology0.81750000
116MP0005384_cellular_phenotype0.81416019
117MP0003937_abnormal_limbs/digits/tail_de0.80370853
118MP0002272_abnormal_nervous_system0.79552057
119MP0003119_abnormal_digestive_system0.79399361
120MP0005171_absent_coat_pigmentation0.78463954
121MP0003221_abnormal_cardiomyocyte_apopto0.77227131
122MP0002722_abnormal_immune_system0.77217126
123MP0001188_hyperpigmentation0.77062122
124MP0002139_abnormal_hepatobiliary_system0.76466821
125MP0003878_abnormal_ear_physiology0.75425706
126MP0005377_hearing/vestibular/ear_phenot0.75425706
127MP0005621_abnormal_cell_physiology0.74530915
128MP0005646_abnormal_pituitary_gland0.74508787
129MP0005195_abnormal_posterior_eye0.74477354
130MP0000703_abnormal_thymus_morphology0.73188621
131MP0001986_abnormal_taste_sensitivity0.72198910
132MP0000598_abnormal_liver_morphology0.71891797
133MP0002184_abnormal_innervation0.71198495
134MP0010352_gastrointestinal_tract_polyps0.71012268
135MP0001293_anophthalmia0.70745199
136MP0002249_abnormal_larynx_morphology0.70252484
137MP0002398_abnormal_bone_marrow0.70125899
138MP0002752_abnormal_somatic_nervous0.68475998
139MP0000678_abnormal_parathyroid_gland0.68119386
140MP0001915_intracranial_hemorrhage0.66135572
141MP0005220_abnormal_exocrine_pancreas0.65846792
142MP0002161_abnormal_fertility/fecundity0.64844944
143MP0002282_abnormal_trachea_morphology0.64668875
144MP0002095_abnormal_skin_pigmentation0.61515363
145MP0005084_abnormal_gallbladder_morpholo0.60957956
146MP0009672_abnormal_birth_weight0.60695012
147MP0001542_abnormal_bone_strength0.59424406
148MP0002269_muscular_atrophy0.59207153
149MP0002429_abnormal_blood_cell0.58645681
150MP0004133_heterotaxia0.57955507
151MP0002111_abnormal_tail_morphology0.53812603
152MP0002127_abnormal_cardiovascular_syste0.52797692
153MP0005075_abnormal_melanosome_morpholog0.51044393
154MP0003938_abnormal_ear_development0.50764249
155MP0005408_hypopigmentation0.50597060
156MP0000477_abnormal_intestine_morphology0.50507636
157MP0005332_abnormal_amino_acid0.50153809

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.97660584
2Breast hypoplasia (HP:0003187)5.31469026
3Acute necrotizing encephalopathy (HP:0006965)4.40034125
4Hyperalaninemia (HP:0003348)4.08938966
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.08938966
6Abnormality of alanine metabolism (HP:0010916)4.08938966
7Abnormal mitochondria in muscle tissue (HP:0008316)4.03269947
8Acute encephalopathy (HP:0006846)3.89708570
9Abnormality of the anterior horn cell (HP:0006802)3.89405157
10Degeneration of anterior horn cells (HP:0002398)3.89405157
11Mitochondrial inheritance (HP:0001427)3.84237047
12Oral leukoplakia (HP:0002745)3.83514512
13Increased CSF lactate (HP:0002490)3.72996590
14Progressive macrocephaly (HP:0004481)3.72857282
15Cerebral hypomyelination (HP:0006808)3.63325744
16Rough bone trabeculation (HP:0100670)3.63250602
17Microretrognathia (HP:0000308)3.62851210
18Patellar aplasia (HP:0006443)3.61651926
19Carpal bone hypoplasia (HP:0001498)3.56544904
20Aplasia/Hypoplasia of the patella (HP:0006498)3.45203057
21Aplastic anemia (HP:0001915)3.43578051
22Increased hepatocellular lipid droplets (HP:0006565)3.30591839
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.25346796
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.25346796
25Reticulocytopenia (HP:0001896)3.23335966
26Secondary amenorrhea (HP:0000869)3.17948862
27Premature ovarian failure (HP:0008209)3.15433857
28Cerebral edema (HP:0002181)3.03212599
29Lipid accumulation in hepatocytes (HP:0006561)2.97186847
30Abnormal number of erythroid precursors (HP:0012131)2.87325765
31Abnormality of cells of the erythroid lineage (HP:0012130)2.84894893
32Meckel diverticulum (HP:0002245)2.79959950
33Hyperglycinemia (HP:0002154)2.78591377
34Renal Fanconi syndrome (HP:0001994)2.78031339
35Supernumerary spleens (HP:0009799)2.74357462
36Abnormality of serum amino acid levels (HP:0003112)2.68956303
37Molar tooth sign on MRI (HP:0002419)2.67214771
38Abnormality of midbrain morphology (HP:0002418)2.67214771
39Abnormality of the ileum (HP:0001549)2.66090379
40Absent radius (HP:0003974)2.65012114
41Colon cancer (HP:0003003)2.64349684
42Abnormality of the preputium (HP:0100587)2.60983218
43Premature graying of hair (HP:0002216)2.59585104
44Chromsome breakage (HP:0040012)2.56892240
45Megaloblastic anemia (HP:0001889)2.55627930
46Abnormality of chromosome stability (HP:0003220)2.54344545
47Lactic acidosis (HP:0003128)2.54223346
48Abnormal trabecular bone morphology (HP:0100671)2.53477163
49Reduced antithrombin III activity (HP:0001976)2.50167664
50Muscle fiber atrophy (HP:0100295)2.48923484
51Macrocytic anemia (HP:0001972)2.47969895
52Absent forearm bone (HP:0003953)2.45308189
53Aplasia involving forearm bones (HP:0009822)2.45308189
54Entropion (HP:0000621)2.45100255
55Type I transferrin isoform profile (HP:0003642)2.45000801
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43761176
57Multiple enchondromatosis (HP:0005701)2.43015334
58Type 2 muscle fiber atrophy (HP:0003554)2.42847047
593-Methylglutaconic aciduria (HP:0003535)2.41343444
60Absent thumb (HP:0009777)2.39472178
61Impulsivity (HP:0100710)2.37916176
62Medial flaring of the eyebrow (HP:0010747)2.37568976
63Selective tooth agenesis (HP:0001592)2.36877039
64Methylmalonic acidemia (HP:0002912)2.35281028
65Increased intramyocellular lipid droplets (HP:0012240)2.34435304
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32562835
67Horseshoe kidney (HP:0000085)2.32523244
68Progressive muscle weakness (HP:0003323)2.32400592
69CNS hypomyelination (HP:0003429)2.31896493
70Increased serum pyruvate (HP:0003542)2.29627290
71Flat capital femoral epiphysis (HP:0003370)2.28671089
72Bone marrow hypocellularity (HP:0005528)2.26779381
73Optic disc pallor (HP:0000543)2.26579056
74Overlapping toe (HP:0001845)2.25886177
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.24519443
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24349531
77Myelodysplasia (HP:0002863)2.23716783
78Sparse eyelashes (HP:0000653)2.22253339
79Abnormality of the labia minora (HP:0012880)2.21173406
80Ureteral duplication (HP:0000073)2.20564000
81True hermaphroditism (HP:0010459)2.19765695
82Neoplasm of the pancreas (HP:0002894)2.18955684
83Pallor (HP:0000980)2.17240795
84Atrophy/Degeneration involving motor neurons (HP:0007373)2.16600056
85Abnormality of pyrimidine metabolism (HP:0004353)2.14423203
86Methylmalonic aciduria (HP:0012120)2.14077792
87Small intestinal stenosis (HP:0012848)2.13998856
88Duodenal stenosis (HP:0100867)2.13998856
89Hyperglycinuria (HP:0003108)2.13043865
90Increased serum lactate (HP:0002151)2.12940030
91Rhabdomyosarcoma (HP:0002859)2.12385295
92Abnormality of glycolysis (HP:0004366)2.10444773
93Type II lissencephaly (HP:0007260)2.09293362
94Abnormality of the umbilical cord (HP:0010881)2.07647035
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07543720
96Retinal dysplasia (HP:0007973)2.06363364
97Slender long bone (HP:0003100)2.05404649
98Capillary hemangiomas (HP:0005306)2.04702140
99Sloping forehead (HP:0000340)2.03287642
100Thrombocytosis (HP:0001894)2.02926123
101Exercise intolerance (HP:0003546)2.02687034
102Personality changes (HP:0000751)2.02280850
103Lissencephaly (HP:0001339)2.01483934
104Respiratory failure (HP:0002878)2.00810218
105Pendular nystagmus (HP:0012043)2.00616203
106Breast aplasia (HP:0100783)1.99615499
107Unsteady gait (HP:0002317)1.99219771
108Cellular immunodeficiency (HP:0005374)1.97051329
109Abnormal spermatogenesis (HP:0008669)1.96997307
110Nephronophthisis (HP:0000090)1.96027096
111Pancytopenia (HP:0001876)1.95603353
112Lethargy (HP:0001254)1.95142880
113Pancreatic fibrosis (HP:0100732)1.94099277
114Agnosia (HP:0010524)1.93554829
115Death in infancy (HP:0001522)1.93106967
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92983277
117Abnormal protein N-linked glycosylation (HP:0012347)1.92983277
118Abnormal protein glycosylation (HP:0012346)1.92983277
119Abnormal glycosylation (HP:0012345)1.92983277
120Aplasia/Hypoplasia of the fovea (HP:0008060)1.92810231
121Hypoplasia of the fovea (HP:0007750)1.92810231
122Short tibia (HP:0005736)1.92117083
123Abnormality of the fovea (HP:0000493)1.91259487
124Aplasia/Hypoplasia of the breasts (HP:0010311)1.90551246
125Leukodystrophy (HP:0002415)1.90545442
126Triphalangeal thumb (HP:0001199)1.90421985
127Congenital primary aphakia (HP:0007707)1.89639194
128Hypoplastic pelvis (HP:0008839)1.89264913
129Generalized aminoaciduria (HP:0002909)1.89254499
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89227083
131Progressive microcephaly (HP:0000253)1.89066306
132Exertional dyspnea (HP:0002875)1.89027768
133Nephrogenic diabetes insipidus (HP:0009806)1.88951449
134Trismus (HP:0000211)1.88270472
135Postnatal microcephaly (HP:0005484)1.87738928
136CNS demyelination (HP:0007305)1.87696642
137Hepatocellular necrosis (HP:0001404)1.86073861
138Abnormality of the duodenum (HP:0002246)1.85215343
139Gait imbalance (HP:0002141)1.84443347
140Medulloblastoma (HP:0002885)1.84323675
141Hepatic necrosis (HP:0002605)1.83143294
142Intestinal atresia (HP:0011100)1.83044528
143Irregular epiphyses (HP:0010582)1.82657026
144Respiratory difficulties (HP:0002880)1.81529940
145Sclerocornea (HP:0000647)1.81290675
146Pancreatic cysts (HP:0001737)1.79710557
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.78917435
148Abnormality of the metopic suture (HP:0005556)1.77291534
149Microvesicular hepatic steatosis (HP:0001414)1.74719741
150Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74181171
151Small hand (HP:0200055)1.73746403
152Ependymoma (HP:0002888)1.73642769
153Increased muscle lipid content (HP:0009058)1.73487109
154Abnormality of the pons (HP:0007361)1.73465475
155Median cleft lip (HP:0000161)1.73171975
156Septo-optic dysplasia (HP:0100842)1.72513610
157Hypothermia (HP:0002045)1.71490065
158Aplasia/hypoplasia of the uterus (HP:0008684)1.71379813
159Abnormal lung lobation (HP:0002101)1.70073160
160Bifid tongue (HP:0010297)1.69684992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.87132939
2WEE14.47038966
3EIF2AK13.54355214
4TRIM283.49522958
5CDC73.11108739
6MAP4K23.07655655
7NME23.05495262
8PLK42.99093856
9VRK22.65158820
10STK162.62712786
11NEK22.62498219
12ACVR1B2.54538493
13WNK32.33559105
14TTK2.33432120
15TSSK62.30484636
16EIF2AK32.16459693
17SRPK12.13183378
18NUAK12.12221444
19BRSK22.09096057
20PLK11.97853355
21MST41.87142111
22ERBB31.85184797
23DYRK31.79583608
24BRAF1.77497416
25BCR1.77167028
26PBK1.76980960
27MAP3K41.69580586
28TESK21.67129500
29NEK11.65831784
30VRK11.64181480
31PDK21.63517565
32BCKDK1.62435308
33LATS21.60463731
34AKT31.54279442
35EPHA21.50116635
36ZAK1.47478759
37CDK81.47114800
38MAP2K71.46494011
39STK38L1.41913326
40PLK31.40309596
41RPS6KA41.37701260
42MKNK21.37295562
43AURKA1.36904623
44BMPR1B1.36062198
45CSNK1A1L1.35585566
46CHEK21.35380633
47AURKB1.35125283
48CDK71.34217111
49MAPK131.33594521
50CCNB11.29968033
51BRSK11.27072686
52TLK11.25973841
53ADRBK21.25704416
54MKNK11.23703605
55TNIK1.20168357
56RPS6KB21.15454594
57MAP3K81.15329614
58PLK21.12340481
59ATR1.09719115
60FRK1.08657163
61ARAF1.07437358
62DYRK21.06093525
63GRK11.03473145
64PIM21.02936689
65MAPKAPK31.01273830
66SIK30.96015017
67MAP3K120.94354195
68MAP3K110.91645632
69MAP3K60.88155695
70EEF2K0.88151473
71CDK40.87376554
72MOS0.86217038
73PASK0.83659577
74FLT30.79702768
75MARK10.78785169
76TAF10.76746587
77EIF2AK20.76359849
78NLK0.75324575
79MINK10.75287170
80STK100.73234037
81MELK0.71392904
82CHEK10.69397814
83STK30.68727677
84PINK10.67117198
85PIM10.65772678
86CSNK2A10.64700211
87INSRR0.64155130
88RAF10.61367581
89KDR0.60167972
90TGFBR10.59998688
91CASK0.59028608
92DAPK10.57806815
93SCYL20.56790992
94ERBB40.56675438
95CDK20.56041002
96PRKCG0.55731989
97LIMK10.55551245
98WNK40.54135279
99PRKCE0.53791465
100PAK10.53661610
101CSNK2A20.53223922
102ATM0.53122825
103NEK90.52796306
104RPS6KA50.52337144
105OXSR10.51770785
106TAOK30.51692841
107TAOK20.51486870
108LATS10.51143401
109PAK40.49464191
110MUSK0.49021510
111ABL20.48885104
112MAP3K50.48724409
113IRAK30.48196320
114PRKCI0.46173496
115CDK30.44369558
116MAPK110.44191658
117MAP4K10.43875314
118TIE10.43298455
119MARK30.42787130
120NME10.42393361
121CSNK1A10.40221089
122TXK0.38878292
123CSNK1G30.38079699
124PAK30.37652892
125CAMKK20.35810130
126CDK10.34766553
127PKN10.31063105
128CSNK1D0.30690442
129ZAP700.29865940
130STK40.29709748
131STK390.28473918
132CSNK1G10.26576292
133CSNK1E0.24095304
134ALK0.23980837
135TEC0.23481170
136BMPR20.22819971
137AKT20.22784244
138CSNK1G20.21154906
139MAP2K20.21013770
140CDK190.20106296
141STK380.14793153
142MAP2K60.11819584
143TAOK10.11432244

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.14905583
2RNA polymerase_Homo sapiens_hsa030204.06655694
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92575341
4Proteasome_Homo sapiens_hsa030503.43556929
5Oxidative phosphorylation_Homo sapiens_hsa001903.42114390
6Mismatch repair_Homo sapiens_hsa034303.35728692
7Ribosome_Homo sapiens_hsa030103.20520830
8RNA transport_Homo sapiens_hsa030133.09317846
9Spliceosome_Homo sapiens_hsa030402.90777526
10Vitamin B6 metabolism_Homo sapiens_hsa007502.89686552
11Pyrimidine metabolism_Homo sapiens_hsa002402.85009727
12Base excision repair_Homo sapiens_hsa034102.81964535
13Homologous recombination_Homo sapiens_hsa034402.81198272
14Cell cycle_Homo sapiens_hsa041102.70933750
15Nucleotide excision repair_Homo sapiens_hsa034202.61191159
16One carbon pool by folate_Homo sapiens_hsa006702.44430859
17Basal transcription factors_Homo sapiens_hsa030222.37050328
18Folate biosynthesis_Homo sapiens_hsa007902.25147598
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11373695
20RNA degradation_Homo sapiens_hsa030182.11184261
21Fanconi anemia pathway_Homo sapiens_hsa034601.98655232
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94721289
23Alzheimers disease_Homo sapiens_hsa050101.77749795
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76030356
25Purine metabolism_Homo sapiens_hsa002301.68542925
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.55713310
27p53 signaling pathway_Homo sapiens_hsa041151.54543055
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49687019
29Steroid biosynthesis_Homo sapiens_hsa001001.44552577
30Protein export_Homo sapiens_hsa030601.41574657
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34800896
32Propanoate metabolism_Homo sapiens_hsa006401.34118951
33Non-homologous end-joining_Homo sapiens_hsa034501.28110276
34Fatty acid elongation_Homo sapiens_hsa000621.27589902
35Sulfur relay system_Homo sapiens_hsa041221.26358981
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.25537726
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25254140
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24972654
39mRNA surveillance pathway_Homo sapiens_hsa030151.24499865
40Butanoate metabolism_Homo sapiens_hsa006501.17567221
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16522147
42Biosynthesis of amino acids_Homo sapiens_hsa012301.15218766
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11111636
44Selenocompound metabolism_Homo sapiens_hsa004501.08197460
45Phototransduction_Homo sapiens_hsa047441.07471159
46Epstein-Barr virus infection_Homo sapiens_hsa051691.06977133
47Pentose phosphate pathway_Homo sapiens_hsa000301.05703277
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.02624590
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00665396
50Cardiac muscle contraction_Homo sapiens_hsa042601.00592747
51Oocyte meiosis_Homo sapiens_hsa041140.96537998
52Regulation of autophagy_Homo sapiens_hsa041400.95876277
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89114686
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84977552
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82978655
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78726940
57Thyroid cancer_Homo sapiens_hsa052160.77152464
58Collecting duct acid secretion_Homo sapiens_hsa049660.70497874
59Herpes simplex infection_Homo sapiens_hsa051680.69298375
60Carbon metabolism_Homo sapiens_hsa012000.61445172
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61173171
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58993825
63Fructose and mannose metabolism_Homo sapiens_hsa000510.57872532
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57586527
65Antigen processing and presentation_Homo sapiens_hsa046120.56975533
66Glutathione metabolism_Homo sapiens_hsa004800.56330681
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55601839
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55392423
69Nicotine addiction_Homo sapiens_hsa050330.53109171
70Caffeine metabolism_Homo sapiens_hsa002320.52344407
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50794987
72Arginine and proline metabolism_Homo sapiens_hsa003300.48808707
73Metabolic pathways_Homo sapiens_hsa011000.48483005
74Galactose metabolism_Homo sapiens_hsa000520.46014562
75Viral carcinogenesis_Homo sapiens_hsa052030.45752220
76N-Glycan biosynthesis_Homo sapiens_hsa005100.43890283
77Huntingtons disease_Homo sapiens_hsa050160.43252501
78Systemic lupus erythematosus_Homo sapiens_hsa053220.41577750
79Tryptophan metabolism_Homo sapiens_hsa003800.41312637
80Circadian rhythm_Homo sapiens_hsa047100.41180470
81HTLV-I infection_Homo sapiens_hsa051660.39808939
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39614309
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.38793247
84Bladder cancer_Homo sapiens_hsa052190.38242111
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37195061
86Olfactory transduction_Homo sapiens_hsa047400.36730614
87Vitamin digestion and absorption_Homo sapiens_hsa049770.36242288
88Asthma_Homo sapiens_hsa053100.35324111
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33726307
90Sulfur metabolism_Homo sapiens_hsa009200.33149112
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32584696
92Alcoholism_Homo sapiens_hsa050340.32071442
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31988817
94Ether lipid metabolism_Homo sapiens_hsa005650.28262070
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27338794
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26312045
97Nitrogen metabolism_Homo sapiens_hsa009100.24289843
98Taste transduction_Homo sapiens_hsa047420.23152965
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22928229
100Fatty acid metabolism_Homo sapiens_hsa012120.21967874
101TGF-beta signaling pathway_Homo sapiens_hsa043500.21843005
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21722828
103Legionellosis_Homo sapiens_hsa051340.20784462
104Vibrio cholerae infection_Homo sapiens_hsa051100.20736687
105Colorectal cancer_Homo sapiens_hsa052100.20514230
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.20234513
107Retinol metabolism_Homo sapiens_hsa008300.18063021
108MicroRNAs in cancer_Homo sapiens_hsa052060.17211734
109Apoptosis_Homo sapiens_hsa042100.16791117
110Other glycan degradation_Homo sapiens_hsa005110.16405748
111Peroxisome_Homo sapiens_hsa041460.16381145
112Primary immunodeficiency_Homo sapiens_hsa053400.15939279
113Shigellosis_Homo sapiens_hsa051310.15850204
114Pyruvate metabolism_Homo sapiens_hsa006200.15590189
115Chemical carcinogenesis_Homo sapiens_hsa052040.15442746
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14576211
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.14093346
118Linoleic acid metabolism_Homo sapiens_hsa005910.13087454
119beta-Alanine metabolism_Homo sapiens_hsa004100.12584697
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12391219
121Parkinsons disease_Homo sapiens_hsa050120.12096833
122Arachidonic acid metabolism_Homo sapiens_hsa005900.11709767
123Small cell lung cancer_Homo sapiens_hsa052220.11518941
124Hepatitis B_Homo sapiens_hsa051610.11365479
125Hedgehog signaling pathway_Homo sapiens_hsa043400.11333741
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10044534
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.09420065
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09273488
129Hippo signaling pathway_Homo sapiens_hsa043900.06615922
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.04831518
131mTOR signaling pathway_Homo sapiens_hsa041500.04782462
132HIF-1 signaling pathway_Homo sapiens_hsa040660.04758484
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.02936778
134FoxO signaling pathway_Homo sapiens_hsa040680.02934748
135Notch signaling pathway_Homo sapiens_hsa043300.02088709
136Renin-angiotensin system_Homo sapiens_hsa046140.01439753

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