ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	plasma lipoprotein particle assembly (GO:0034377)	8.56489136
2	cholesterol efflux (GO:0033344)	8.46244626
3	regulation of triglyceride catabolic process (GO:0010896)	8.21742583
4	protein-lipid complex remodeling (GO:0034368)	8.09979094
5	macromolecular complex remodeling (GO:0034367)	8.09979094
6	plasma lipoprotein particle remodeling (GO:0034369)	8.09979094
7	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	7.50024549
8	protein-lipid complex assembly (GO:0065005)	7.45620359
9	very-low-density lipoprotein particle assembly (GO:0034379)	6.98007434
10	negative regulation of cholesterol transport (GO:0032375)	6.35576325
11	negative regulation of sterol transport (GO:0032372)	6.35576325
12	ovulation from ovarian follicle (GO:0001542)	6.18246573
13	plasma lipoprotein particle organization (GO:0071827)	6.13533955
14	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	5.85733581
15	protein-lipid complex subunit organization (GO:0071825)	5.67784633
16	negative regulation of lipase activity (GO:0060192)	5.53595455
17	plasma lipoprotein particle clearance (GO:0034381)	5.39363485
18	low-density lipoprotein particle remodeling (GO:0034374)	5.38651057
19	cellular ketone body metabolic process (GO:0046950)	5.22742745
20	sterol transport (GO:0015918)	5.11445621
21	cholesterol transport (GO:0030301)	5.11445621
22	regulation of cytokine secretion involved in immune response (GO:0002739)	4.98276818
23	ketone body metabolic process (GO:1902224)	4.61862229
24	lipoprotein transport (GO:0042953)	4.58374873
25	positive regulation of lipid catabolic process (GO:0050996)	4.17809609
26	regulation of lipoprotein particle clearance (GO:0010984)	4.12615803
27	removal of superoxide radicals (GO:0019430)	4.09837298
28	cellular response to superoxide (GO:0071451)	4.09837298
29	cellular response to oxygen radical (GO:0071450)	4.09837298
30	positive regulation of triglyceride lipase activity (GO:0061365)	4.07906700
31	positive regulation of lipoprotein lipase activity (GO:0051006)	4.07906700
32	phospholipid homeostasis (GO:0055091)	4.00230576
33	acylglycerol homeostasis (GO:0055090)	3.97191006
34	triglyceride homeostasis (GO:0070328)	3.97191006
35	neutral lipid catabolic process (GO:0046461)	3.82951811
36	acylglycerol catabolic process (GO:0046464)	3.82951811
37	cholesterol homeostasis (GO:0042632)	3.81794376
38	regulation of lipoprotein metabolic process (GO:0050746)	3.81305535
39	negative regulation of receptor-mediated endocytosis (GO:0048261)	3.77664626
40	regulation of sterol transport (GO:0032371)	3.76526314
41	regulation of cholesterol transport (GO:0032374)	3.76526314
42	sterol homeostasis (GO:0055092)	3.72433377
43	keratinocyte development (GO:0003334)	3.71060496
44	tricarboxylic acid metabolic process (GO:0072350)	3.69078833
45	SMAD protein signal transduction (GO:0060395)	3.68268571
46	synaptic vesicle maturation (GO:0016188)	3.67356203
47	carnitine transport (GO:0015879)	3.60912815
48	amino-acid betaine transport (GO:0015838)	3.60912815
49	glutamine family amino acid biosynthetic process (GO:0009084)	3.59288647
50	lipoprotein metabolic process (GO:0042157)	3.57444405
51	water-soluble vitamin biosynthetic process (GO:0042364)	3.57052522
52	regulation of heterotypic cell-cell adhesion (GO:0034114)	3.55362738
53	regulation of digestive system process (GO:0044058)	3.54299608
54	phosphatidylcholine biosynthetic process (GO:0006656)	3.45929863
55	regulation of triglyceride metabolic process (GO:0090207)	3.45303966
56	response to phenylpropanoid (GO:0080184)	3.42983585
57	progesterone metabolic process (GO:0042448)	3.42939862
58	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.42624479
59	positive regulation of steroid metabolic process (GO:0045940)	3.33355805
60	glycerolipid catabolic process (GO:0046503)	3.33324831
61	negative regulation of lipid catabolic process (GO:0050995)	3.33081914
62	arginine catabolic process (GO:0006527)	3.21409297
63	phototransduction, visible light (GO:0007603)	3.18121937
64	cellular response to zinc ion (GO:0071294)	3.15922121
65	response to superoxide (GO:0000303)	3.12156371
66	transepithelial transport (GO:0070633)	3.09672402
67	C21-steroid hormone metabolic process (GO:0008207)	3.09468077
68	genitalia morphogenesis (GO:0035112)	3.04127511
69	retinoid metabolic process (GO:0001523)	3.02842048
70	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.02767502
71	early endosome to late endosome transport (GO:0045022)	3.00482076
72	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.99012166
73	C4-dicarboxylate transport (GO:0015740)	2.97366687
74	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.93092660
75	positive regulation of triglyceride metabolic process (GO:0090208)	2.91919112
76	amine catabolic process (GO:0009310)	2.90647810
77	cellular biogenic amine catabolic process (GO:0042402)	2.90647810
78	positive regulation of protein targeting to membrane (GO:0090314)	2.88201241
79	detection of visible light (GO:0009584)	2.86136931
80	L-ascorbic acid metabolic process (GO:0019852)	2.85437221
81	heme transport (GO:0015886)	2.84331492
82	response to oxygen radical (GO:0000305)	2.83940728
83	organic hydroxy compound transport (GO:0015850)	2.82902974
84	intestinal absorption (GO:0050892)	2.79978826
85	phospholipid catabolic process (GO:0009395)	2.79924586
86	ovulation (GO:0030728)	2.77142737
87	diterpenoid metabolic process (GO:0016101)	2.76443503
88	hydrogen peroxide catabolic process (GO:0042744)	2.75113396
89	triglyceride catabolic process (GO:0019433)	2.70717457
90	peptidyl-glutamic acid carboxylation (GO:0017187)	2.69442637
91	protein carboxylation (GO:0018214)	2.69442637
92	glutathione derivative biosynthetic process (GO:1901687)	2.68131159
93	glutathione derivative metabolic process (GO:1901685)	2.68131159
94	quaternary ammonium group transport (GO:0015697)	2.66441446
95	glycerophospholipid catabolic process (GO:0046475)	2.66031395
96	regulation of fatty acid biosynthetic process (GO:0042304)	2.65122058
97	high-density lipoprotein particle remodeling (GO:0034375)	12.6114473
98	phospholipid efflux (GO:0033700)	11.6196222
99	reverse cholesterol transport (GO:0043691)	10.7451287
100	regulation of cholesterol esterification (GO:0010872)	10.5620710

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.08517099
2	VDR_22108803_ChIP-Seq_LS180_Human	3.81259837
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.99273479
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.96242811
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.92474196
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.76738409
7	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.71478160
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.58599894
9	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.49231821
10	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.25275218
11	TP53_16413492_ChIP-PET_HCT116_Human	2.08878717
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.99889623
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.98428965
14	BCAT_22108803_ChIP-Seq_LS180_Human	1.88104437
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82513015
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.78014896
17	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.64412729
18	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.64412729
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62849453
20	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.60949766
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59260055
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58287932
23	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56978869
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.56505448
25	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.52421928
26	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.51076059
27	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49972181
28	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49972181
29	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.49223503
30	TCF4_22108803_ChIP-Seq_LS180_Human	1.47125857
31	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.47069528
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.44203600
33	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.43143528
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42380860
35	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.42376728
36	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.39901505
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39654645
38	GBX2_23144817_ChIP-Seq_PC3_Human	1.38206769
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36324442
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34383433
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32106771
42	GATA1_22025678_ChIP-Seq_K562_Human	1.31738543
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31058067
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30765161
45	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.30327724
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29167589
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25380476
48	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24669015
49	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.24569142
50	CDX2_22108803_ChIP-Seq_LS180_Human	1.23514430
51	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22585065
52	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.22378553
53	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.21970452
54	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.21780707
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21345293
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20694876
57	TCF4_23295773_ChIP-Seq_U87_Human	1.19952862
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19355625
59	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.19258242
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18950491
61	STAT3_23295773_ChIP-Seq_U87_Human	1.18757302
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.18145105
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18079891
64	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.17876644
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.14731465
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14731465
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14066279
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13866906
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12221212
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11180058
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10656819
72	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.10564255
73	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.10062227
74	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.09771069
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09367345
76	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.09027742
77	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.07571542
78	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.05891216
79	AR_25329375_ChIP-Seq_VCAP_Human	1.05365324
80	NCOR_22424771_ChIP-Seq_293T_Human	1.04378883
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04324620
82	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.03957514
83	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.03232729
84	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.03190829
85	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.02973158
86	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.02810678
87	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.00762287
88	GATA4_25053715_ChIP-Seq_YYC3_Human	1.00322819
89	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00294660
90	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.99479724
91	SMAD4_21799915_ChIP-Seq_A2780_Human	0.99426255
92	PHF8_20622853_ChIP-Seq_HELA_Human	0.98696476
93	TBL1_22424771_ChIP-Seq_293T_Human	0.98402278
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.97411128
95	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96610646
96	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.94932278
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94823146
98	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.94717825
99	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.94032372
100	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.93844371

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	9.41031967
2	MP0002876_abnormal_thyroid_physiology	4.79609191
3	MP0001986_abnormal_taste_sensitivity	4.48212037
4	MP0008875_abnormal_xenobiotic_pharmacok	4.06186736
5	MP0005187_abnormal_penis_morphology	3.47200229
6	MP0005379_endocrine/exocrine_gland_phen	3.28227749
7	MP0010329_abnormal_lipoprotein_level	3.08163388
8	MP0004133_heterotaxia	3.04165474
9	MP0000566_synostosis	2.99939695
10	MP0005360_urolithiasis	2.98985750
11	MP0004270_analgesia	2.85447272
12	MP0003315_abnormal_perineum_morphology	2.76480431
13	MP0002163_abnormal_gland_morphology	2.61655090
14	MP0000647_abnormal_sebaceous_gland	2.39650208
15	MP0003191_abnormal_cellular_cholesterol	2.39393076
16	MP0004142_abnormal_muscle_tone	2.15239190
17	MP0002938_white_spotting	1.95945794
18	MP0002090_abnormal_vision	1.86669411
19	MP0005332_abnormal_amino_acid	1.86405608
20	MP0004019_abnormal_vitamin_homeostasis	1.71961172
21	MP0002837_dystrophic_cardiac_calcinosis	1.66513686
22	MP0003950_abnormal_plasma_membrane	1.66180525
23	MP0005551_abnormal_eye_electrophysiolog	1.61179394
24	MP0010030_abnormal_orbit_morphology	1.53351224
25	MP0005257_abnormal_intraocular_pressure	1.39643487
26	MP0005085_abnormal_gallbladder_physiolo	1.37481774
27	MP0002160_abnormal_reproductive_system	1.36512016
28	MP0003943_abnormal_hepatobiliary_system	1.33232697
29	MP0005389_reproductive_system_phenotype	1.28147728
30	MP0000372_irregular_coat_pigmentation	1.25354701
31	MP0001346_abnormal_lacrimal_gland	1.24757685
32	MP0005365_abnormal_bile_salt	1.24378625
33	MP0002928_abnormal_bile_duct	1.19120992
34	MP0003718_maternal_effect	1.16992873
35	MP0002557_abnormal_social/conspecific_i	1.11506098
36	MP0001119_abnormal_female_reproductive	1.08501648
37	MP0001666_abnormal_nutrient_absorption	1.05638523
38	MP0001765_abnormal_ion_homeostasis	1.05121353
39	MP0000427_abnormal_hair_cycle	1.04280844
40	MP0001299_abnormal_eye_distance/	1.03156266
41	MP0004147_increased_porphyrin_level	1.02193015
42	MP0000569_abnormal_digit_pigmentation	0.99709467
43	MP0003136_yellow_coat_color	0.99366107
44	MP0003878_abnormal_ear_physiology	0.98201507
45	MP0005377_hearing/vestibular/ear_phenot	0.98201507
46	MP0009046_muscle_twitch	0.97496034
47	MP0008995_early_reproductive_senescence	0.95975874
48	MP0003699_abnormal_female_reproductive	0.94793903
49	MP0003252_abnormal_bile_duct	0.91915704
50	MP0001727_abnormal_embryo_implantation	0.91120905
51	MP0003632_abnormal_nervous_system	0.90780271
52	MP0003122_maternal_imprinting	0.90538359
53	MP0001905_abnormal_dopamine_level	0.90136122
54	MP0002295_abnormal_pulmonary_circulatio	0.88756066
55	MP0000653_abnormal_sex_gland	0.87888703
56	MP0003953_abnormal_hormone_level	0.87349722
57	MP0000639_abnormal_adrenal_gland	0.86551647
58	MP0002734_abnormal_mechanical_nocicepti	0.86268860
59	MP0001929_abnormal_gametogenesis	0.84080129
60	MP0005636_abnormal_mineral_homeostasis	0.82423866
61	MP0001485_abnormal_pinna_reflex	0.81978497
62	MP0002118_abnormal_lipid_homeostasis	0.81363616
63	MP0001944_abnormal_pancreas_morphology	0.79954362
64	MP0004145_abnormal_muscle_electrophysio	0.79076596
65	MP0005646_abnormal_pituitary_gland	0.78092044
66	MP0006054_spinal_hemorrhage	0.77114824
67	MP0000003_abnormal_adipose_tissue	0.76968248
68	MP0000013_abnormal_adipose_tissue	0.76536067
69	MP0002139_abnormal_hepatobiliary_system	0.75653225
70	MP0008569_lethality_at_weaning	0.73571496
71	MP0009745_abnormal_behavioral_response	0.72450467
72	MP0000681_abnormal_thyroid_gland	0.70702162
73	MP0009643_abnormal_urine_homeostasis	0.69008792
74	MP0003186_abnormal_redox_activity	0.67755859
75	MP0009642_abnormal_blood_homeostasis	0.67381681
76	MP0003283_abnormal_digestive_organ	0.67261713
77	MP0003698_abnormal_male_reproductive	0.64293757
78	MP0001293_anophthalmia	0.64152368
79	MP0008872_abnormal_physiological_respon	0.63288009
80	MP0003755_abnormal_palate_morphology	0.62081663
81	MP0005164_abnormal_response_to	0.61960272
82	MP0001486_abnormal_startle_reflex	0.61364632
83	MP0006276_abnormal_autonomic_nervous	0.60974680
84	MP0000383_abnormal_hair_follicle	0.60831517
85	MP0001919_abnormal_reproductive_system	0.60472543
86	MP0001984_abnormal_olfaction	0.58754611
87	MP0002136_abnormal_kidney_physiology	0.57407000
88	MP0001764_abnormal_homeostasis	0.57128205
89	MP0000609_abnormal_liver_physiology	0.55954700
90	MP0002078_abnormal_glucose_homeostasis	0.54777524
91	MP0000631_abnormal_neuroendocrine_gland	0.53948719
92	MP0001145_abnormal_male_reproductive	0.53312097
93	MP0002127_abnormal_cardiovascular_syste	0.53109516
94	MP0001756_abnormal_urination	0.52153986
95	MP0002161_abnormal_fertility/fecundity	0.51632329
96	MP0002069_abnormal_eating/drinking_beha	0.51250328
97	MP0001501_abnormal_sleep_pattern	0.51110599
98	MP0002254_reproductive_system_inflammat	0.49133293
99	MP0005395_other_phenotype	0.48634976
100	MP0005595_abnormal_vascular_smooth	0.48285832

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypobetalipoproteinemia (HP:0003563)	7.69691172
2	Chronic hepatic failure (HP:0100626)	5.65918160
3	Supernumerary spleens (HP:0009799)	4.65573298
4	Spontaneous abortion (HP:0005268)	4.50556736
5	Hypolipoproteinemia (HP:0010981)	4.41270465
6	Hyperlipoproteinemia (HP:0010980)	4.30970972
7	Volvulus (HP:0002580)	4.25005517
8	Retinal atrophy (HP:0001105)	3.88616309
9	Abnormal biliary tract physiology (HP:0012439)	3.73174578
10	Bile duct proliferation (HP:0001408)	3.73174578
11	Occipital encephalocele (HP:0002085)	3.56800816
12	Severe muscular hypotonia (HP:0006829)	3.54666357
13	Popliteal pterygium (HP:0009756)	3.44557591
14	Abnormality of the common coagulation pathway (HP:0010990)	3.37988444
15	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.34448905
16	Concave nail (HP:0001598)	3.08734231
17	Pigmentary retinal degeneration (HP:0001146)	3.06573151
18	Hypoglycemic coma (HP:0001325)	3.02416501
19	Pulmonary artery stenosis (HP:0004415)	3.01545519
20	Hypoglycemic seizures (HP:0002173)	2.98410918
21	Cerebellar dysplasia (HP:0007033)	2.96585503
22	Nausea (HP:0002018)	2.96566992
23	Pancreatic cysts (HP:0001737)	2.89925798
24	Gingival bleeding (HP:0000225)	2.89044056
25	Malnutrition (HP:0004395)	2.88291241
26	Abnormal umbilical cord blood vessels (HP:0011403)	2.76093247
27	Single umbilical artery (HP:0001195)	2.76093247
28	Abnormality of the fetal cardiovascular system (HP:0010948)	2.76093247
29	Absent speech (HP:0001344)	2.73645775
30	True hermaphroditism (HP:0010459)	2.73630311
31	Natal tooth (HP:0000695)	2.68474544
32	Large for gestational age (HP:0001520)	2.68224963
33	Asplenia (HP:0001746)	2.67805229
34	Pancreatic fibrosis (HP:0100732)	2.65126748
35	Hypomagnesemia (HP:0002917)	2.64769241
36	Abnormality of the nasal septum (HP:0000419)	2.56258846
37	Stomach cancer (HP:0012126)	2.55234005
38	Truncal obesity (HP:0001956)	2.54297111
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.48623743
40	Genetic anticipation (HP:0003743)	2.45412740
41	Increased CSF lactate (HP:0002490)	2.38260305
42	Hypoplasia of the fovea (HP:0007750)	2.38198786
43	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.38198786
44	Vacuolated lymphocytes (HP:0001922)	2.38011013
45	Severe visual impairment (HP:0001141)	2.32437035
46	Short tibia (HP:0005736)	2.30458012
47	Tubulointerstitial nephritis (HP:0001970)	2.27617026
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.27311301
49	Blepharitis (HP:0000498)	2.26756208
50	Acute encephalopathy (HP:0006846)	2.25464094
51	Retinal dysplasia (HP:0007973)	2.23795728
52	Fat malabsorption (HP:0002630)	2.23004546
53	Increased nuchal translucency (HP:0010880)	2.20115768
54	Abnormal delivery (HP:0001787)	2.19903269
55	Breech presentation (HP:0001623)	2.18545557
56	Hyperglycinemia (HP:0002154)	2.15644053
57	Hyperinsulinemic hypoglycemia (HP:0000825)	2.15232586
58	Abnormality of the fovea (HP:0000493)	2.15101138
59	Self-mutilation (HP:0000742)	2.13560919
60	Acute necrotizing encephalopathy (HP:0006965)	2.09047479
61	Abnormality of midbrain morphology (HP:0002418)	2.08909226
62	Molar tooth sign on MRI (HP:0002419)	2.08909226
63	Abnormality of macular pigmentation (HP:0008002)	2.06892823
64	Male pseudohermaphroditism (HP:0000037)	2.04260009
65	Thin upper lip vermilion (HP:0000219)	2.02353896
66	Abnormality of pyrimidine metabolism (HP:0004353)	1.98458684
67	Epidermoid cyst (HP:0200040)	1.97220799
68	Intellectual disability, moderate (HP:0002342)	1.97100710
69	Congenital hepatic fibrosis (HP:0002612)	1.92836144
70	Short humerus (HP:0005792)	1.92629954
71	Abnormality of magnesium homeostasis (HP:0004921)	1.92142590
72	Symptomatic seizures (HP:0011145)	1.91446598
73	Aplasia/hypoplasia of the humerus (HP:0006507)	1.90521434
74	Cystic liver disease (HP:0006706)	1.90317559
75	Progressive cerebellar ataxia (HP:0002073)	1.89077481
76	Exostoses (HP:0100777)	1.88757069
77	Poor eye contact (HP:0000817)	1.88587734
78	Abnormal mitochondria in muscle tissue (HP:0008316)	1.88474881
79	Hyperglycinuria (HP:0003108)	1.87047783
80	Optic disc pallor (HP:0000543)	1.85861001
81	Joint swelling (HP:0001386)	1.85857433
82	Anterior segment dysgenesis (HP:0007700)	1.85246044
83	Intrahepatic cholestasis (HP:0001406)	1.82245064
84	Joint hemorrhage (HP:0005261)	1.80591695
85	Abnormal rod and cone electroretinograms (HP:0008323)	1.80491766
86	CNS hypomyelination (HP:0003429)	1.78978762
87	Congenital primary aphakia (HP:0007707)	1.78798054
88	Abnormality of the renal cortex (HP:0011035)	1.77498988
89	Type II lissencephaly (HP:0007260)	1.77420385
90	Hypothermia (HP:0002045)	1.77298564
91	Stage 5 chronic kidney disease (HP:0003774)	1.76999101
92	Progressive microcephaly (HP:0000253)	1.76405870
93	Attenuation of retinal blood vessels (HP:0007843)	1.75909358
94	Genital tract atresia (HP:0001827)	1.75826023
95	Progressive macrocephaly (HP:0004481)	1.75737497
96	Mitochondrial inheritance (HP:0001427)	1.75701490
97	Medial flaring of the eyebrow (HP:0010747)	1.75606311
98	Amyloidosis (HP:0011034)	1.75135447
99	Adrenal hypoplasia (HP:0000835)	1.74628705
100	Vaginal atresia (HP:0000148)	1.74249132

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	6.42987765
2	MUSK	5.03791463
3	MAP3K12	4.34839125
4	PDK2	3.98218779
5	TESK2	2.99945801
6	TLK1	2.95114098
7	TNIK	2.78713007
8	PAK3	2.77653399
9	MST4	2.64583387
10	ACVR1B	2.54216352
11	GRK1	2.42698694
12	PBK	2.42003112
13	ZAK	2.22373591
14	FGFR2	2.13420328
15	BRSK2	1.78516281
16	PLK2	1.78386271
17	MKNK2	1.78147066
18	CASK	1.74081824
19	WEE1	1.71464606
20	NEK9	1.50914996
21	MAP4K2	1.50846944
22	PINK1	1.45262203
23	WNK3	1.42763150
24	PNCK	1.41075537
25	PRKCG	1.27863388
26	WNK4	1.26013747
27	FRK	1.24846156
28	MAP3K7	1.19427524
29	FER	1.13678835
30	PHKG1	1.03414506
31	PHKG2	1.03414506
32	BMPR1B	1.02829613
33	IRAK3	1.02259028
34	FGFR1	0.97909681
35	LMTK2	0.94707378
36	PRKCI	0.92296955
37	MAPK11	0.90700489
38	NME1	0.88759684
39	BUB1	0.88426615
40	PKN2	0.86015385
41	FLT3	0.83032745
42	EIF2AK3	0.80714441
43	MAP3K11	0.78601136
44	AKT2	0.77787179
45	PRKAA2	0.76827155
46	MAP2K4	0.74761364
47	BCKDK	0.74474981
48	PRKCE	0.69700384
49	MAP2K1	0.67700699
50	PLK3	0.62944518
51	MKNK1	0.62063483
52	BRSK1	0.58903191
53	STK3	0.58111362
54	MAP3K4	0.53417727
55	PRKAA1	0.52283540
56	PRKCH	0.51365861
57	INSRR	0.49924774
58	PRKACB	0.48359271
59	NLK	0.47591473
60	AKT3	0.47361660
61	PTK2B	0.47106437
62	PLK1	0.42381667
63	TGFBR1	0.42090912
64	OBSCN	0.40543149
65	MAP2K6	0.39778555
66	PRKCA	0.38057114
67	BCR	0.36753781
68	DYRK2	0.36235297
69	MYLK	0.36187193
70	ADRBK2	0.33857519
71	NEK1	0.33214343
72	EPHA4	0.28266898
73	STK38L	0.27663102
74	PRKACG	0.26445979
75	PDK1	0.25942921
76	INSR	0.25664970
77	CSNK2A1	0.25479654
78	PRKCB	0.24940755
79	TYK2	0.22672848
80	PTK2	0.21703709
81	MET	0.21017028
82	CSNK1G2	0.20460853
83	CSNK1E	0.19812716
84	CSNK1D	0.18875865
85	PRKCQ	0.18808727
86	WNK1	0.18247883
87	SGK494	0.16914664
88	SGK223	0.16914664
89	MAPK13	0.16886406
90	MAP3K2	0.16879391
91	ABL1	0.16750972
92	PRKACA	0.16383960
93	PRKCZ	0.16347213
94	TRIM28	0.16000549
95	ERBB2	0.15947125
96	PRKD1	0.14797625
97	CAMK2D	0.12985155
98	MAPK15	0.12948131
99	NTRK3	0.12773070
100	GSK3A	0.11086739

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.52957298
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.15932584
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.13275850
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.02100857
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.83538812
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.81196351
7	Caffeine metabolism_Homo sapiens_hsa00232	2.77812499
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.72109902
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.59089428
10	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.32424122
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.30292001
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.25824323
13	Butanoate metabolism_Homo sapiens_hsa00650	2.17942747
14	Arginine biosynthesis_Homo sapiens_hsa00220	2.07754198
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.07513534
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.96415996
17	Galactose metabolism_Homo sapiens_hsa00052	1.96284443
18	PPAR signaling pathway_Homo sapiens_hsa03320	1.95131335
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.94408667
20	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.84627947
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.79721475
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.79673934
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.78939794
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.75986012
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.63377817
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.63295638
27	ABC transporters_Homo sapiens_hsa02010	1.60274717
28	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.56226531
29	Mineral absorption_Homo sapiens_hsa04978	1.54891998
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.44847282
31	Complement and coagulation cascades_Homo sapiens_hsa04610	1.38233497
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.33524361
33	Oxidative phosphorylation_Homo sapiens_hsa00190	1.26397855
34	Sphingolipid metabolism_Homo sapiens_hsa00600	1.25689099
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.21703494
36	Propanoate metabolism_Homo sapiens_hsa00640	1.21621233
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.21494147
38	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.20725709
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.16274660
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.14822186
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08218890
42	Peroxisome_Homo sapiens_hsa04146	1.05598403
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.05354037
44	Parkinsons disease_Homo sapiens_hsa05012	1.01328896
45	Glutathione metabolism_Homo sapiens_hsa00480	1.01033656
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98910112
47	African trypanosomiasis_Homo sapiens_hsa05143	0.98022669
48	Circadian rhythm_Homo sapiens_hsa04710	0.97843628
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95930339
50	Retinol metabolism_Homo sapiens_hsa00830	0.95797952
51	Phototransduction_Homo sapiens_hsa04744	0.95537836
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.95318902
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93568801
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80870322
55	GnRH signaling pathway_Homo sapiens_hsa04912	0.79156350
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.77779738
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76163578
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76070059
59	Alzheimers disease_Homo sapiens_hsa05010	0.75298156
60	Huntingtons disease_Homo sapiens_hsa05016	0.70953041
61	Carbon metabolism_Homo sapiens_hsa01200	0.66743041
62	Metabolic pathways_Homo sapiens_hsa01100	0.65781902
63	Bile secretion_Homo sapiens_hsa04976	0.61334677
64	Sulfur metabolism_Homo sapiens_hsa00920	0.58913047
65	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.55325483
66	Fatty acid degradation_Homo sapiens_hsa00071	0.54213320
67	Salivary secretion_Homo sapiens_hsa04970	0.54117959
68	Glucagon signaling pathway_Homo sapiens_hsa04922	0.52428354
69	RNA polymerase_Homo sapiens_hsa03020	0.52419910
70	Serotonergic synapse_Homo sapiens_hsa04726	0.51427472
71	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47445506
72	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.45882471
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.45119816
74	Circadian entrainment_Homo sapiens_hsa04713	0.44918419
75	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.44587379
76	Proteasome_Homo sapiens_hsa03050	0.43405564
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41945294
78	Other glycan degradation_Homo sapiens_hsa00511	0.39832326
79	GABAergic synapse_Homo sapiens_hsa04727	0.39156050
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38783506
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.35229688
82	Histidine metabolism_Homo sapiens_hsa00340	0.35219018
83	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.34720275
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31757549
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.29805418
86	Fatty acid elongation_Homo sapiens_hsa00062	0.27471609
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27189466
88	RNA degradation_Homo sapiens_hsa03018	0.26940185
89	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.26703769
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25853576
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25096544
92	Protein export_Homo sapiens_hsa03060	0.24768907
93	Insulin secretion_Homo sapiens_hsa04911	0.24039272
94	Cardiac muscle contraction_Homo sapiens_hsa04260	0.24008735
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.22670817
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.21294285
97	One carbon pool by folate_Homo sapiens_hsa00670	0.21215188
98	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.20320922
99	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.20138627
100	Morphine addiction_Homo sapiens_hsa05032	0.20114819

DUSP12P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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