DUSP13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.63547872
2cell wall macromolecule metabolic process (GO:0044036)9.43812188
3cell wall macromolecule catabolic process (GO:0016998)9.43812188
4fusion of sperm to egg plasma membrane (GO:0007342)8.94752669
5muscle filament sliding (GO:0030049)8.67916516
6actin-myosin filament sliding (GO:0033275)8.67916516
7sperm-egg recognition (GO:0035036)8.27999511
8skeletal muscle contraction (GO:0003009)8.23779196
9acrosome assembly (GO:0001675)8.08076824
10regulation of skeletal muscle contraction (GO:0014819)7.85199689
11regulation of relaxation of muscle (GO:1901077)7.77999060
12binding of sperm to zona pellucida (GO:0007339)7.56578524
13cell-cell recognition (GO:0009988)7.39856088
14sarcoplasmic reticulum calcium ion transport (GO:0070296)7.28499937
15multicellular organism reproduction (GO:0032504)7.25269880
16motile cilium assembly (GO:0044458)7.09636034
17spermatid development (GO:0007286)7.01147686
18plasma membrane fusion (GO:0045026)6.99755272
19actin-mediated cell contraction (GO:0070252)6.98342423
20skeletal muscle adaptation (GO:0043501)6.84095183
21epithelial cilium movement (GO:0003351)6.53769744
22axonemal dynein complex assembly (GO:0070286)6.53177881
23reproduction (GO:0000003)6.27619327
24skeletal muscle fiber development (GO:0048741)6.09773604
25regulation of cilium movement (GO:0003352)6.09550342
26negative regulation of inclusion body assembly (GO:0090084)6.07522768
27cardiac myofibril assembly (GO:0055003)5.87803846
28cardiac muscle contraction (GO:0060048)5.69695970
29sperm capacitation (GO:0048240)5.48094765
30skeletal muscle tissue regeneration (GO:0043403)5.41439106
31synaptonemal complex organization (GO:0070193)5.35707089
32cilium or flagellum-dependent cell motility (GO:0001539)5.35601521
33NADH metabolic process (GO:0006734)5.26652350
34actomyosin structure organization (GO:0031032)5.26611151
35carnitine transmembrane transport (GO:1902603)5.16506567
36muscle cell cellular homeostasis (GO:0046716)5.16106958
37cilium movement (GO:0003341)5.15473803
38regulation of inclusion body assembly (GO:0090083)5.14700566
39myotube cell development (GO:0014904)5.10890702
40actin filament-based movement (GO:0030048)5.09097361
41organic cation transport (GO:0015695)5.08343175
42carnitine transport (GO:0015879)5.04187438
43amino-acid betaine transport (GO:0015838)5.04187438
44single fertilization (GO:0007338)5.00495834
45skeletal muscle tissue development (GO:0007519)5.00310632
46synaptonemal complex assembly (GO:0007130)4.96347549
47plasma membrane repair (GO:0001778)4.94888799
48* spermatogenesis (GO:0007283)4.92755319
49negative regulation of potassium ion transmembrane transport (GO:1901380)4.90806743
50* male gamete generation (GO:0048232)4.90624452
51regulation of actin filament-based movement (GO:1903115)4.83098754
52response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.79041156
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.74053812
54regulation of cell communication by electrical coupling (GO:0010649)4.73569954
55piRNA metabolic process (GO:0034587)4.68336327
56striated muscle contraction (GO:0006941)4.60566907
57carnitine shuttle (GO:0006853)4.55085615
58male meiosis (GO:0007140)4.51684483
59regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.50555178
60* gamete generation (GO:0007276)4.47223759
61cardiac muscle hypertrophy (GO:0003300)4.43848105
62fructose metabolic process (GO:0006000)4.39919900
63glycogen catabolic process (GO:0005980)4.36364791
64purine nucleotide salvage (GO:0032261)4.35608672
65negative regulation of skeletal muscle tissue development (GO:0048642)4.35546953
66fertilization (GO:0009566)4.31166648
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.28715267
68striated muscle hypertrophy (GO:0014897)4.23290532
69regulation of striated muscle contraction (GO:0006942)4.18942231
70striated muscle atrophy (GO:0014891)4.18867122
71muscle organ morphogenesis (GO:0048644)4.17272491
722-oxoglutarate metabolic process (GO:0006103)4.15566049
73muscle tissue morphogenesis (GO:0060415)4.14346344
74response to inactivity (GO:0014854)4.13332848
75gluconeogenesis (GO:0006094)4.12405158
76sarcomere organization (GO:0045214)4.11703321
77muscle organ development (GO:0007517)4.11200122
78muscle structure development (GO:0061061)4.09830135
79glucan catabolic process (GO:0009251)4.07336758
80calcium ion-dependent exocytosis (GO:0017156)4.06401452
81glycogen metabolic process (GO:0005977)4.02868397
82muscle contraction (GO:0006936)4.02446927
83creatine metabolic process (GO:0006600)3.98806358
84chromosome condensation (GO:0030261)3.98780257
85response to activity (GO:0014823)3.98414195
86glycerol ether metabolic process (GO:0006662)3.98262417
87tricarboxylic acid cycle (GO:0006099)3.96976076
88cellular glucan metabolic process (GO:0006073)3.95042765
89glucan metabolic process (GO:0044042)3.95042765
90cardiac muscle tissue morphogenesis (GO:0055008)3.92306023
91striated muscle cell development (GO:0055002)3.91953218
92microtubule depolymerization (GO:0007019)3.86139157
93cellular process involved in reproduction in multicellular organism (GO:0022412)3.82771795
94fatty acid transmembrane transport (GO:1902001)3.81653603
95glycolytic process (GO:0006096)3.79281540
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.79277617
97muscle hypertrophy (GO:0014896)3.78583540
98DNA packaging (GO:0006323)3.76110891
99cellular polysaccharide catabolic process (GO:0044247)3.75567184
100pyrimidine ribonucleoside catabolic process (GO:0046133)3.75292454
101germ cell development (GO:0007281)3.74071453
102muscle adaptation (GO:0043500)3.73011708
103IMP metabolic process (GO:0046040)3.72144015
104hexose biosynthetic process (GO:0019319)3.71478244
105heart process (GO:0003015)3.71057511
106heart contraction (GO:0060047)3.71057511
107ether metabolic process (GO:0018904)3.65324896
108microtubule severing (GO:0051013)3.63322474
109cellular carbohydrate catabolic process (GO:0044275)3.60500054
110myofibril assembly (GO:0030239)3.59295817
111glycogen biosynthetic process (GO:0005978)3.58594803
112glucan biosynthetic process (GO:0009250)3.58594803
113muscle cell fate commitment (GO:0042693)3.58088424
114sequestering of actin monomers (GO:0042989)3.57399220
115polysaccharide catabolic process (GO:0000272)3.55968188
116adult heart development (GO:0007512)3.54489465
117muscle atrophy (GO:0014889)3.54360781
118muscle system process (GO:0003012)3.51380941
119regulation of microtubule-based movement (GO:0060632)3.51095877
120positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.50590860
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.50546367
122quaternary ammonium group transport (GO:0015697)3.49024643
123* multicellular organismal reproductive process (GO:0048609)3.47487975
124myoblast fusion (GO:0007520)3.46116089
125regulation of calcium ion transmembrane transporter activity (GO:1901019)3.45962747
126regulation of calcium ion transmembrane transport (GO:1903169)3.45962747
127cardiac muscle cell development (GO:0055013)3.45954713
128striated muscle adaptation (GO:0014888)3.45056290
129ubiquinone biosynthetic process (GO:0006744)3.44741609
130response to muscle activity (GO:0014850)3.42502812
131negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.41962951
132negative regulation of calcium ion transmembrane transport (GO:1903170)3.41962951
133cell recognition (GO:0008037)3.41718794
134striated muscle tissue development (GO:0014706)3.41164042
135seminiferous tubule development (GO:0072520)3.39152077
136muscle fiber development (GO:0048747)3.38796152
137oxaloacetate metabolic process (GO:0006107)3.38566792
138negative regulation of muscle contraction (GO:0045932)3.35986316
139negative regulation of protein localization to cell surface (GO:2000009)3.35822347
140muscle cell development (GO:0055001)3.35184123
141negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.34892774
142neuromuscular synaptic transmission (GO:0007274)3.33863177
143regulation of myoblast differentiation (GO:0045661)3.32470390
144myotube differentiation (GO:0014902)3.28367682
145negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.27121186
146regulation of the force of heart contraction (GO:0002026)3.25347557
147regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.24373216
148AMP metabolic process (GO:0046033)3.23287650
149monosaccharide biosynthetic process (GO:0046364)3.23245607
150regulation of sequestering of triglyceride (GO:0010889)3.22129745
151male meiosis I (GO:0007141)3.22087879
152regulation of muscle system process (GO:0090257)3.21835628
153neuronal action potential propagation (GO:0019227)3.21348059
154positive regulation of myotube differentiation (GO:0010831)3.21341647
155muscle hypertrophy in response to stress (GO:0003299)3.21121511
156ventricular system development (GO:0021591)3.16462352
157regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.11377403
158syncytium formation by plasma membrane fusion (GO:0000768)3.10020397
159left/right pattern formation (GO:0060972)3.08087454
160sperm motility (GO:0030317)10.2036727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.68654914
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.49119343
3EZH2_22144423_ChIP-Seq_EOC_Human3.93238056
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.64845447
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.27055060
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.26704666
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.10665097
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.04685648
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.96546056
10ZNF274_21170338_ChIP-Seq_K562_Hela2.38674283
11* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.38497364
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.37987835
13VDR_22108803_ChIP-Seq_LS180_Human2.33742374
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17850315
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12370755
16NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.10313646
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04427717
18* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.97802845
19PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.96749271
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81880469
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.80183008
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70983657
23GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.67439814
24* CBP_20019798_ChIP-Seq_JUKART_Human1.61158330
25* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61158330
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61082667
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.61034642
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60797374
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.60539344
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.60539344
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.59263783
32LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.55847007
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.54712025
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53211355
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51992254
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50630986
37* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48370717
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47572194
39CTCF_27219007_Chip-Seq_Bcells_Human1.47214603
40GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.45403523
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.45146242
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.43428221
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.43356453
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.42373057
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.41014729
46FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40679471
47P53_21459846_ChIP-Seq_SAOS-2_Human1.39658980
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38688896
49MYC_27129775_Chip-Seq_CORNEA_Mouse1.38605207
50SMC3_22415368_ChIP-Seq_MEFs_Mouse1.37661233
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37298016
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36039116
53SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35510880
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35448131
55STAT1_17558387_ChIP-Seq_HELA_Human1.34902515
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33435307
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33163860
58GATA3_21867929_ChIP-Seq_CD8_Mouse1.31852530
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30086432
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.30059203
61STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.28729864
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.27169097
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26964921
64ZNF263_19887448_ChIP-Seq_K562_Human1.26122879
65GATA1_19941827_ChIP-Seq_MEL86_Mouse1.23522892
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.23303711
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21847427
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21695908
69NANOG_20526341_ChIP-Seq_ESCs_Human1.21053098
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20683989
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.20648962
72RAC3_21632823_ChIP-Seq_H3396_Human1.19172825
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19078295
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18869657
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18564909
76BCL6_27268052_Chip-Seq_Bcells_Human1.18324722
77BCOR_27268052_Chip-Seq_Bcells_Human1.17400879
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.16014392
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15357839
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14925863
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14249925
82* CTCF_21964334_Chip-Seq_Bcells_Human1.14079040
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13957111
84CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13937772
85* CTCF_26484167_Chip-Seq_Bcells_Mouse1.13585214
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11306160
87JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11019446
88SA1_27219007_Chip-Seq_Bcells_Human1.10349713
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.09372195
90CLOCK_20551151_ChIP-Seq_293T_Human1.09293440
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.09099700
92LXR_22292898_ChIP-Seq_THP-1_Human1.08525505
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08304808
94OCT4_20526341_ChIP-Seq_ESCs_Human1.08263108
95OCT1_27270436_Chip-Seq_PROSTATE_Human1.07733655
96* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06993157
97CSB_26484114_Chip-Seq_FIBROBLAST_Human1.06900862
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06860393
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05130164
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.04573634
101SPI1_20517297_ChIP-Seq_HL60_Human1.04345718
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.03426285
103* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02720419
104AR_21572438_ChIP-Seq_LNCaP_Human1.02566017
105GF1_26923725_Chip-Seq_HPCs_Mouse1.02270523
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02256902
107* FOXH1_21741376_ChIP-Seq_ESCs_Human1.02024742
108KDM2B_26808549_Chip-Seq_REH_Human1.01102965
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.00995764
110ERG_20517297_ChIP-Seq_VCAP_Human1.00961883
111SPI1_26923725_Chip-Seq_HPCs_Mouse1.00537520
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00143209
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00050144
114GATA3_21867929_ChIP-Seq_TH1_Mouse0.99842508
115IGF1R_20145208_ChIP-Seq_DFB_Human0.98886582
116* STAT1_20625510_ChIP-Seq_HELA_Human0.98538625
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98333904
118E2F1_20622854_ChIP-Seq_HELA_Human0.97427981
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.97096800
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96246095
121RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95711018
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95178726
123CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95123488
124SOX11_22085726_ChIP-Seq_ESNs_Mouse0.94430706
125KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93997767
126EGR1_19032775_ChIP-ChIP_M12_Human0.93936915
127* TP63_22573176_ChIP-Seq_HFKS_Human0.93690051
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93497724
129SMC4_20622854_ChIP-Seq_HELA_Human0.93447261
130* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93139061
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92973134
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.92262771
133CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92212077
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91699294
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91439617
136PHF8_20622854_ChIP-Seq_HELA_Human0.91038239
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90624855
138KLF4_19829295_ChIP-Seq_ESCs_Human0.90461848
139CTCF_20526341_ChIP-Seq_ESCs_Human0.90160763
140CBX2_27304074_Chip-Seq_ESCs_Mouse0.88170021
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88121062
142SOX2_21211035_ChIP-Seq_LN229_Human0.88056461
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87800010
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.87702941
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87407512
146KDM2B_26808549_Chip-Seq_DND41_Human0.84969398
147LXR_22158963_ChIP-Seq_LIVER_Mouse0.81921738
148PHF8_20622853_ChIP-Seq_HELA_Human0.81451163
149TCF7_22412390_ChIP-Seq_EML_Mouse0.81054357
150GATA1_19941826_ChIP-Seq_K562_Human0.79699190
151FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79135280
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78001041
153* RACK7_27058665_Chip-Seq_MCF-7_Human0.77959633
154GATA2_19941826_ChIP-Seq_K562_Human0.76812891
155EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.76265460
156P68_20966046_ChIP-Seq_HELA_Human0.76058652
157TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75736420
158DROSHA_22980978_ChIP-Seq_HELA_Human0.75144813
159RBPJ_21746931_ChIP-Seq_IB4_Human0.73534825
160EZH2_27294783_Chip-Seq_NPCs_Mouse0.73006802
161DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72196382
162CBX2_22325352_ChIP-Seq_293T-Rex_Human0.72182752
163CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72118672
164GATA1_22025678_ChIP-Seq_K562_Human0.71609640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.55498314
2MP0004145_abnormal_muscle_electrophysio6.97403143
3MP0003646_muscle_fatigue6.25587224
4MP0000749_muscle_degeneration5.44733711
5MP0000751_myopathy4.73878992
6MP0002106_abnormal_muscle_physiology3.65261713
7MP0000747_muscle_weakness3.62644593
8MP0004036_abnormal_muscle_relaxation3.40098297
9MP0000759_abnormal_skeletal_muscle3.30434649
10MP0002269_muscular_atrophy3.22597447
11MP0004233_abnormal_muscle_weight3.08319459
12MP0005369_muscle_phenotype3.07377927
13MP0004087_abnormal_muscle_fiber3.00015248
14MP0003698_abnormal_male_reproductive2.89788366
15MP0000750_abnormal_muscle_regeneration2.71832937
16MP0004130_abnormal_muscle_cell2.67321048
17MP0001929_abnormal_gametogenesis2.53125104
18MP0005620_abnormal_muscle_contractility2.47353592
19MP0000733_abnormal_muscle_development2.47213485
20MP0002837_dystrophic_cardiac_calcinosis2.46363517
21MP0005670_abnormal_white_adipose2.27399872
22MP0002108_abnormal_muscle_morphology2.06323163
23MP0000013_abnormal_adipose_tissue2.01005228
24MP0006036_abnormal_mitochondrial_physio1.82279468
25MP0002332_abnormal_exercise_endurance1.58414803
26MP0005666_abnormal_adipose_tissue1.50686270
27MP0002971_abnormal_brown_adipose1.50216436
28MP0002161_abnormal_fertility/fecundity1.46840769
29MP0004270_analgesia1.44206389
30MP0004510_myositis1.39245699
31MP0005330_cardiomyopathy1.33347163
32MP0002210_abnormal_sex_determination1.28694883
33MP0005375_adipose_tissue_phenotype1.22491653
34MP0004084_abnormal_cardiac_muscle1.18834849
35MP0004185_abnormal_adipocyte_glucose1.17467448
36MP0008877_abnormal_DNA_methylation1.13421249
37MP0002234_abnormal_pharynx_morphology1.09200676
38MP0001145_abnormal_male_reproductive1.05000138
39MP0010630_abnormal_cardiac_muscle1.00981486
40MP0001661_extended_life_span0.97816959
41MP0006035_abnormal_mitochondrial_morpho0.96553594
42MP0008775_abnormal_heart_ventricle0.96500097
43MP0004215_abnormal_myocardial_fiber0.93571711
44MP0003806_abnormal_nucleotide_metabolis0.89861154
45MP0003950_abnormal_plasma_membrane0.89500805
46MP0002822_catalepsy0.87066154
47MP0000653_abnormal_sex_gland0.86424799
48MP0002972_abnormal_cardiac_muscle0.85471145
49MP0005266_abnormal_metabolism0.79856951
50MP0000003_abnormal_adipose_tissue0.78186292
51MP0004484_altered_response_of0.77988639
52MP0003828_pulmonary_edema0.76773633
53MP0003221_abnormal_cardiomyocyte_apopto0.76543271
54MP0008961_abnormal_basal_metabolism0.75897210
55MP0004134_abnormal_chest_morphology0.66470602
56MP0009780_abnormal_chondrocyte_physiolo0.66256762
57MP0004085_abnormal_heartbeat0.63424918
58MP0001765_abnormal_ion_homeostasis0.62398486
59MP0009250_abnormal_appendicular_skeleto0.57469890
60MP0001544_abnormal_cardiovascular_syste0.56663690
61MP0005385_cardiovascular_system_phenoty0.56663690
62MP0004043_abnormal_pH_regulation0.54633789
63MP0002653_abnormal_ependyma_morphology0.54529143
64MP0010030_abnormal_orbit_morphology0.51962410
65MP0000372_irregular_coat_pigmentation0.50319466
66MP0005334_abnormal_fat_pad0.49122275
67MP0003959_abnormal_lean_body0.47091725
68MP0009115_abnormal_fat_cell0.44435541
69MP0001849_ear_inflammation0.41209989
70MP0005167_abnormal_blood-brain_barrier0.41107754
71MP0002078_abnormal_glucose_homeostasis0.40884648
72MP0001299_abnormal_eye_distance/0.40576323
73MP0004142_abnormal_muscle_tone0.40301175
74MP0008569_lethality_at_weaning0.40180451
75MP0003656_abnormal_erythrocyte_physiolo0.40155415
76MP0009672_abnormal_birth_weight0.38869223
77MP0000266_abnormal_heart_morphology0.36975897
78MP0003137_abnormal_impulse_conducting0.36894359
79MP0003948_abnormal_gas_homeostasis0.36208123
80MP0005332_abnormal_amino_acid0.35172940
81MP0001346_abnormal_lacrimal_gland0.35121662
82MP0000358_abnormal_cell_content/0.34681883
83MP0004147_increased_porphyrin_level0.34334535
84MP0005623_abnormal_meninges_morphology0.34294925
85MP0005636_abnormal_mineral_homeostasis0.34019068
86MP0002128_abnormal_blood_circulation0.33773464
87MP0003045_fibrosis0.33671853
88MP0005584_abnormal_enzyme/coenzyme_acti0.33464619
89MP0005319_abnormal_enzyme/_coenzyme0.33432850
90MP0002160_abnormal_reproductive_system0.33230218
91MP0002114_abnormal_axial_skeleton0.32373866
92MP0005166_decreased_susceptibility_to0.31673321
93MP0002127_abnormal_cardiovascular_syste0.31269856
94MP0000343_altered_response_to0.30789675
95MP0005452_abnormal_adipose_tissue0.30313624
96MP0002734_abnormal_mechanical_nocicepti0.29075565
97MP0003879_abnormal_hair_cell0.27073963
98MP0003705_abnormal_hypodermis_morpholog0.27029241
99MP0002249_abnormal_larynx_morphology0.26230654
100MP0005165_increased_susceptibility_to0.26208176
101MP0000230_abnormal_systemic_arterial0.23503758
102MP0005083_abnormal_biliary_tract0.22700371
103MP0002638_abnormal_pupillary_reflex0.22563473
104MP0004858_abnormal_nervous_system0.20761482
105MP0004197_abnormal_fetal_growth/weight/0.20669466
106MP0000762_abnormal_tongue_morphology0.20363715
107MP0005535_abnormal_body_temperature0.19912275
108MP0005503_abnormal_tendon_morphology0.19495953
109MP0002282_abnormal_trachea_morphology0.19263421
110MP0009840_abnormal_foam_cell0.19027050
111MP0003011_delayed_dark_adaptation0.18757315
112MP0006138_congestive_heart_failure0.18556047
113MP0008770_decreased_survivor_rate0.18445962
114MP0002118_abnormal_lipid_homeostasis0.18279454
115MP0002896_abnormal_bone_mineralization0.17864347
116MP0001943_abnormal_respiration0.17661400
117MP0002066_abnormal_motor_capabilities/c0.17349287
118MP0005376_homeostasis/metabolism_phenot0.17154984
119MP0001529_abnormal_vocalization0.15799765
120MP0001984_abnormal_olfaction0.15490880
121MP0003329_amyloid_beta_deposits0.14553751
122MP0003956_abnormal_body_size0.13592942
123MP0002932_abnormal_joint_morphology0.13546950
124MP0005451_abnormal_body_composition0.13433796
125MP0000678_abnormal_parathyroid_gland0.13426098
126MP0003941_abnormal_skin_development0.12365682

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.23416052
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.87224768
3Nemaline bodies (HP:0003798)8.46505351
4Exercise-induced myalgia (HP:0003738)7.95280175
5Exercise-induced muscle cramps (HP:0003710)6.92838487
6Type 1 muscle fiber predominance (HP:0003803)6.78728832
7Distal arthrogryposis (HP:0005684)6.54091843
8Ulnar deviation of the wrist (HP:0003049)5.97332114
9Myopathic facies (HP:0002058)5.90309616
10Muscle hypertrophy of the lower extremities (HP:0008968)5.55852302
11Round ear (HP:0100830)5.52366625
12Dynein arm defect of respiratory motile cilia (HP:0012255)5.45546997
13Absent/shortened dynein arms (HP:0200106)5.45546997
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.34276973
15Hyporeflexia of lower limbs (HP:0002600)5.09975529
16Calf muscle hypertrophy (HP:0008981)4.92204964
17Myoglobinuria (HP:0002913)4.92043158
18Difficulty running (HP:0009046)4.88969092
19Calcaneovalgus deformity (HP:0001848)4.65661279
20Muscle fiber splitting (HP:0003555)4.58797608
21Deformed tarsal bones (HP:0008119)4.50076979
22Absent phalangeal crease (HP:0006109)4.37402035
23Rhabdomyolysis (HP:0003201)4.31748090
24Muscle stiffness (HP:0003552)4.06138977
25Abnormal finger flexion creases (HP:0006143)3.83646839
26EMG: myopathic abnormalities (HP:0003458)3.83177936
27Abnormality of the neuromuscular junction (HP:0003398)3.78230931
28Fatigable weakness (HP:0003473)3.78230931
29Malignant hyperthermia (HP:0002047)3.67423468
30Increased connective tissue (HP:0009025)3.63949248
31Abnormal respiratory motile cilium physiology (HP:0012261)3.63903579
32Abnormal respiratory motile cilium morphology (HP:0005938)3.54120236
33Abnormal respiratory epithelium morphology (HP:0012253)3.54120236
34Difficulty climbing stairs (HP:0003551)3.40082253
35Abnormality of the calf musculature (HP:0001430)3.32414004
36Abnormality of skeletal muscle fiber size (HP:0012084)3.30008331
37Myotonia (HP:0002486)3.27156143
38Hyperkalemia (HP:0002153)3.06393955
39Infertility (HP:0000789)3.03575173
40Neck muscle weakness (HP:0000467)3.01479137
41Bulbar palsy (HP:0001283)3.00862725
42Areflexia of lower limbs (HP:0002522)2.99885415
43Increased variability in muscle fiber diameter (HP:0003557)2.96750128
44Asymmetric septal hypertrophy (HP:0001670)2.95720293
45Rhinitis (HP:0012384)2.90190594
46Frequent falls (HP:0002359)2.90147289
47EMG: neuropathic changes (HP:0003445)2.88950538
48Chronic bronchitis (HP:0004469)2.87957095
49Generalized muscle weakness (HP:0003324)2.83655052
50Weak cry (HP:0001612)2.79845481
51Rimmed vacuoles (HP:0003805)2.74124627
52Subaortic stenosis (HP:0001682)2.74022381
53Abnormality of the left ventricular outflow tract (HP:0011103)2.74022381
54Abnormality of the calcaneus (HP:0008364)2.70850034
55Type 2 muscle fiber atrophy (HP:0003554)2.68235098
56Nasal polyposis (HP:0100582)2.66094704
57Distal lower limb amyotrophy (HP:0008944)2.60801272
58Gowers sign (HP:0003391)2.60763862
59Abnormal ciliary motility (HP:0012262)2.57532996
60Shoulder girdle muscle weakness (HP:0003547)2.54463518
61Nonprogressive disorder (HP:0003680)2.54021260
62Fetal akinesia sequence (HP:0001989)2.52547354
63Pelvic girdle muscle weakness (HP:0003749)2.51085048
64Easy fatigability (HP:0003388)2.46295587
65Abnormality of the hip-girdle musculature (HP:0001445)2.44311286
66Abnormality of the musculature of the pelvis (HP:0001469)2.44311286
67Dilated cardiomyopathy (HP:0001644)2.40676231
68Muscle fiber atrophy (HP:0100295)2.38070928
69Distal lower limb muscle weakness (HP:0009053)2.31448949
70Ventricular tachycardia (HP:0004756)2.24770147
71Abnormality of the nasal mucosa (HP:0000433)2.16850849
72Lipoatrophy (HP:0100578)2.14111760
73Muscular dystrophy (HP:0003560)2.13647854
74Amniotic constriction ring (HP:0009775)2.13276281
75Abnormality of placental membranes (HP:0011409)2.13276281
76Paralysis (HP:0003470)2.12863664
77Male infertility (HP:0003251)2.10095595
78Mildly elevated creatine phosphokinase (HP:0008180)2.09061085
79Progressive muscle weakness (HP:0003323)2.04161052
80Slender build (HP:0001533)2.03676908
81Sudden death (HP:0001699)2.02130997
82Facial diplegia (HP:0001349)2.01120748
83Spinal rigidity (HP:0003306)1.97201709
84Exercise intolerance (HP:0003546)1.94980276
85Lower limb amyotrophy (HP:0007210)1.94439728
86Proximal amyotrophy (HP:0007126)1.92572217
87Abnormality of the foot musculature (HP:0001436)1.90034732
88Centrally nucleated skeletal muscle fibers (HP:0003687)1.84006033
89Ulnar deviation of finger (HP:0009465)1.82592602
90Limb-girdle muscle weakness (HP:0003325)1.82474256
91Abnormal gallbladder physiology (HP:0012438)1.80609421
92Cholecystitis (HP:0001082)1.80609421
93Foot dorsiflexor weakness (HP:0009027)1.76637947
94Heart block (HP:0012722)1.75782972
95Ragged-red muscle fibers (HP:0003200)1.74750449
96Waddling gait (HP:0002515)1.73387163
97Bundle branch block (HP:0011710)1.72002154
98Hypoplastic ischia (HP:0003175)1.71615762
99Long clavicles (HP:0000890)1.70824323
100Bell-shaped thorax (HP:0001591)1.68967692
101Abnormal atrioventricular conduction (HP:0005150)1.65557050
102Short palpebral fissure (HP:0012745)1.63987194
103Metatarsus adductus (HP:0001840)1.63489634
104Ventricular arrhythmia (HP:0004308)1.62263855
105Increased intramyocellular lipid droplets (HP:0012240)1.62252413
106Respiratory insufficiency due to muscle weakness (HP:0002747)1.62248945
107Bronchitis (HP:0012387)1.60931013
108Scapular winging (HP:0003691)1.56227286
109Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.55352628
110Abnormality of the shoulder girdle musculature (HP:0001435)1.54600900
111Limb-girdle muscle atrophy (HP:0003797)1.52598477
112Aplasia of the musculature (HP:0100854)1.50692326
113Popliteal pterygium (HP:0009756)1.50134336
114Increased muscle lipid content (HP:0009058)1.49173134
115Bronchiectasis (HP:0002110)1.47917109
116Achilles tendon contracture (HP:0001771)1.46751660
117Abnormality of the ischium (HP:0003174)1.46164872
118Hip contracture (HP:0003273)1.45009721
119Limited hip movement (HP:0008800)1.37273157
120Congenital hip dislocation (HP:0001374)1.31899667
121Abnormal mitochondria in muscle tissue (HP:0008316)1.27338780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.40671470
2PDK45.78230015
3PDK35.78230015
4TTN4.17113227
5TESK14.04547787
6PDK23.91050002
7PHKG23.63240942
8PHKG13.63240942
9PRKD33.36674243
10NME13.17041829
11ICK3.11244871
12PIK3CG2.74882175
13MUSK2.65784414
14PINK12.23524525
15MAP2K32.14774108
16TRIB32.05859481
17PTK2B1.39463528
18MAP2K61.38996632
19MAP3K71.31101926
20NEK11.22688459
21STK381.21697984
22DYRK1B1.14845289
23MAPK121.13362414
24DMPK1.00699235
25MAP2K41.00266392
26PNCK0.91769471
27PDK10.88220818
28MARK10.82623582
29PIK3CA0.81893692
30WNK40.77698448
31STK390.75683117
32MAP3K30.74989339
33NEK20.71951253
34BCKDK0.71355299
35KSR20.71013857
36PRKAA10.70110635
37PDPK10.69239246
38DYRK30.69217919
39EEF2K0.68138777
40MAP3K130.58332180
41MAP3K100.53589261
42CAMK2D0.53508408
43MAPKAPK30.53181655
44CAMK40.53137372
45AKT20.51728957
46TAOK10.51673465
47PRKAA20.48520954
48CCNB10.47891828
49TAOK20.45776391
50MAP3K110.44016935
51NEK90.42391523
52CAMK2B0.40903615
53CAMK2G0.40285312
54RIPK10.39776933
55MOS0.38530707
56CAMK10.37630950
57MAP3K50.36258735
58EPHB10.36183132
59SGK30.32071284
60MAPK130.31479976
61TBK10.29678304
62ZAK0.29306497
63WNK10.28990441
64SIK10.28466880
65STK30.27895722
66CAMK1G0.27727298
67RIPK40.27381562
68ERBB30.25361837
69RAF10.24804553
70TIE10.24438556
71TYRO30.24370070
72LATS20.24111415
73RPS6KB20.23993958
74ARAF0.23600311
75ILK0.22196749
76TRPM70.21958529
77MAP3K10.21757116
78PRKG10.21577891
79PTK60.21221399
80PAK40.21079907
81CDK190.19257602
82MTOR0.19152891
83MAP2K10.19071783
84MAPK150.17242404
85IRAK10.16688038
86RPS6KA30.16123818
87MAPK110.16083926
88PKN10.14878847
89MAPK40.14125039
90PRKACB0.14043346
91SGK20.13528212
92DAPK20.12920342
93RPS6KB10.12485349
94ZAP700.12478551
95RPS6KA10.12374797
96CDK60.12326053
97KSR10.11905180
98RPS6KC10.09574856
99RPS6KL10.09574856
100PRKD10.08953181
101SGK10.08894672
102PAK10.08462753
103PRKACA0.08198848
104MAPK70.07782464
105STK110.07257820
106PAK20.07020051
107BRAF0.06221606
108PRKCG0.05894580
109RPS6KA60.05222886
110MARK20.05199312
111PAK60.04813707
112STK160.03598256
113PKN20.03453686
114GSK3B0.03416316
115PRKG20.02960272
116IRAK20.02695521
117ROCK10.02510849
118MAPK90.02495637
119MAPK30.02468136
120TNK20.02461510
121STK240.02141525
122MAPK80.02086826
123DAPK30.01452524
124TTK0.01449370
125STK38L0.01315431
126MARK30.01158202
127CSNK1D0.00197987
128PRKACG0.00131700
129GSK3A-0.0141250
130CAMK2A-0.0129959
131PRKCA-0.0113480
132MAPK10-0.0041794
133LIMK1-0.0027071

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.01184652
2Cardiac muscle contraction_Homo sapiens_hsa042603.50117928
3Fatty acid biosynthesis_Homo sapiens_hsa000613.27544517
4Glucagon signaling pathway_Homo sapiens_hsa049223.23876038
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.06056718
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.92709452
7Propanoate metabolism_Homo sapiens_hsa006402.91339824
8Pyruvate metabolism_Homo sapiens_hsa006202.77680887
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.54341044
10Dilated cardiomyopathy_Homo sapiens_hsa054142.24180200
11Fructose and mannose metabolism_Homo sapiens_hsa000512.19618299
12Carbon metabolism_Homo sapiens_hsa012002.18508485
13Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.12423888
14Starch and sucrose metabolism_Homo sapiens_hsa005002.01010188
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00644142
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.93847020
17Arginine biosynthesis_Homo sapiens_hsa002201.91407711
18Linoleic acid metabolism_Homo sapiens_hsa005911.89526137
19Insulin signaling pathway_Homo sapiens_hsa049101.69317862
20Fatty acid degradation_Homo sapiens_hsa000711.66585187
21Oxytocin signaling pathway_Homo sapiens_hsa049211.65567140
22Vitamin B6 metabolism_Homo sapiens_hsa007501.61506067
23AMPK signaling pathway_Homo sapiens_hsa041521.56953514
24Pentose phosphate pathway_Homo sapiens_hsa000301.56317599
25Insulin resistance_Homo sapiens_hsa049311.55817887
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53633813
27Circadian rhythm_Homo sapiens_hsa047101.53492659
28Calcium signaling pathway_Homo sapiens_hsa040201.51113523
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50323934
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.49499853
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47619936
32PPAR signaling pathway_Homo sapiens_hsa033201.41379997
33Fatty acid metabolism_Homo sapiens_hsa012121.37644591
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36066936
35Biosynthesis of amino acids_Homo sapiens_hsa012301.31668333
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21184694
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.20694349
38Galactose metabolism_Homo sapiens_hsa000521.14110749
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08718910
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05611186
41Glycerolipid metabolism_Homo sapiens_hsa005611.03349247
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02756556
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.02293075
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.01446861
45Renin secretion_Homo sapiens_hsa049240.95441195
46Alzheimers disease_Homo sapiens_hsa050100.94691518
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94645898
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92152787
49Huntingtons disease_Homo sapiens_hsa050160.91418812
50Fat digestion and absorption_Homo sapiens_hsa049750.90361309
51Parkinsons disease_Homo sapiens_hsa050120.89076087
52Nitrogen metabolism_Homo sapiens_hsa009100.88064631
53Phenylalanine metabolism_Homo sapiens_hsa003600.87893651
54Selenocompound metabolism_Homo sapiens_hsa004500.87335423
55Tight junction_Homo sapiens_hsa045300.85175482
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81843157
57Oxidative phosphorylation_Homo sapiens_hsa001900.81157680
58VEGF signaling pathway_Homo sapiens_hsa043700.80168815
59Dorso-ventral axis formation_Homo sapiens_hsa043200.79567125
60Insulin secretion_Homo sapiens_hsa049110.78840757
61Arginine and proline metabolism_Homo sapiens_hsa003300.78478087
62HIF-1 signaling pathway_Homo sapiens_hsa040660.77614594
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77016836
64Fatty acid elongation_Homo sapiens_hsa000620.76423172
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76135431
66Gastric acid secretion_Homo sapiens_hsa049710.72372551
67Oocyte meiosis_Homo sapiens_hsa041140.70187342
68Purine metabolism_Homo sapiens_hsa002300.63917298
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61542938
70Butanoate metabolism_Homo sapiens_hsa006500.60822058
71Viral myocarditis_Homo sapiens_hsa054160.60620870
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56659012
73MAPK signaling pathway_Homo sapiens_hsa040100.55905274
74Amphetamine addiction_Homo sapiens_hsa050310.55735025
75Legionellosis_Homo sapiens_hsa051340.52946847
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51819066
77Ether lipid metabolism_Homo sapiens_hsa005650.51767744
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.46779362
79mTOR signaling pathway_Homo sapiens_hsa041500.45563428
80FoxO signaling pathway_Homo sapiens_hsa040680.45465488
81beta-Alanine metabolism_Homo sapiens_hsa004100.44810441
82Mineral absorption_Homo sapiens_hsa049780.44462172
83Peroxisome_Homo sapiens_hsa041460.42409634
84Long-term potentiation_Homo sapiens_hsa047200.41858435
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39225309
86Focal adhesion_Homo sapiens_hsa045100.37157227
87Collecting duct acid secretion_Homo sapiens_hsa049660.35457290
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33800575
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32250994
90Tyrosine metabolism_Homo sapiens_hsa003500.32027417
91Pancreatic secretion_Homo sapiens_hsa049720.31154643
92Basal transcription factors_Homo sapiens_hsa030220.30302229
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29959496
94Tryptophan metabolism_Homo sapiens_hsa003800.29541730
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28983270
96Hedgehog signaling pathway_Homo sapiens_hsa043400.28371370
97Type II diabetes mellitus_Homo sapiens_hsa049300.27010744
98Arachidonic acid metabolism_Homo sapiens_hsa005900.26921814
99Lysine degradation_Homo sapiens_hsa003100.25951127
100GnRH signaling pathway_Homo sapiens_hsa049120.25596931
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24009289
102Metabolic pathways_Homo sapiens_hsa011000.23354123
103Bile secretion_Homo sapiens_hsa049760.22426249
104Thyroid cancer_Homo sapiens_hsa052160.20637228
105Salivary secretion_Homo sapiens_hsa049700.19941391
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18991437
107ABC transporters_Homo sapiens_hsa020100.17190992
108Estrogen signaling pathway_Homo sapiens_hsa049150.17028163
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16991530
110Circadian entrainment_Homo sapiens_hsa047130.16881964
111Systemic lupus erythematosus_Homo sapiens_hsa053220.16675858
112Long-term depression_Homo sapiens_hsa047300.16192521
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16131810
114Glutathione metabolism_Homo sapiens_hsa004800.15976986
115Sulfur relay system_Homo sapiens_hsa041220.15235327
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14706975
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14279627
118Glioma_Homo sapiens_hsa052140.13380622
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13287921
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.12581810
121Endocytosis_Homo sapiens_hsa041440.12545147
122Olfactory transduction_Homo sapiens_hsa047400.12184163
123Cholinergic synapse_Homo sapiens_hsa047250.10378070
124Regulation of autophagy_Homo sapiens_hsa041400.07460826
125Platelet activation_Homo sapiens_hsa046110.05913318
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.05164180
127Proteasome_Homo sapiens_hsa030500.04790033
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.04308804
129Amoebiasis_Homo sapiens_hsa051460.03007009
130cAMP signaling pathway_Homo sapiens_hsa040240.02636457
131Adherens junction_Homo sapiens_hsa045200.01930817

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