DUSP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.17018166
2mitotic metaphase plate congression (GO:0007080)4.79634027
3hemidesmosome assembly (GO:0031581)4.60446164
4COPI coating of Golgi vesicle (GO:0048205)4.51322842
5Golgi transport vesicle coating (GO:0048200)4.51322842
6skin morphogenesis (GO:0043589)4.25976745
7protein maturation by protein folding (GO:0022417)4.20616516
8regulation of meiosis (GO:0040020)4.12026171
9desmosome organization (GO:0002934)4.11369854
10proteasome assembly (GO:0043248)3.97016021
11glutamate secretion (GO:0014047)3.90075642
12regulation of histone H3-K27 methylation (GO:0061085)3.89802566
13negative regulation of hormone metabolic process (GO:0032351)3.80750662
14negative regulation of hormone biosynthetic process (GO:0032353)3.80750662
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74163231
16piRNA metabolic process (GO:0034587)3.68352189
17protein K6-linked ubiquitination (GO:0085020)3.67855753
18microtubule severing (GO:0051013)3.64008640
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59407724
20positive regulation of synapse maturation (GO:0090129)3.57409804
21protein retention in ER lumen (GO:0006621)3.53516725
22metaphase plate congression (GO:0051310)3.52072708
23regulation of meiosis I (GO:0060631)3.49866717
24regulation of meiotic cell cycle (GO:0051445)3.49729682
25nuclear envelope reassembly (GO:0031468)3.49585465
26mitotic nuclear envelope reassembly (GO:0007084)3.49585465
27regulation of female gonad development (GO:2000194)3.48349993
28interferon-gamma secretion (GO:0072643)3.47655918
29maturation of 5.8S rRNA (GO:0000460)3.44861208
30neurotransmitter-gated ion channel clustering (GO:0072578)3.43609718
31protein deneddylation (GO:0000338)3.43073112
32presynaptic membrane assembly (GO:0097105)3.36412810
33rRNA modification (GO:0000154)3.31925569
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24439241
35regulation of exit from mitosis (GO:0007096)3.23685793
36negative regulation of meiosis (GO:0045835)3.23198528
37establishment of chromosome localization (GO:0051303)3.22613057
38regulation of synaptic vesicle exocytosis (GO:2000300)3.22493198
39hair cycle (GO:0042633)3.22208897
40molting cycle (GO:0042303)3.22208897
41cerebellar granule cell differentiation (GO:0021707)3.21910489
42regulation of short-term neuronal synaptic plasticity (GO:0048172)3.18456281
43regulation of synaptic vesicle transport (GO:1902803)3.17389275
44female gamete generation (GO:0007292)3.17357684
45sensory perception of smell (GO:0007608)3.17043568
46cell adhesion mediated by integrin (GO:0033627)3.15369066
47nucleobase-containing small molecule interconversion (GO:0015949)3.14625951
48synaptic vesicle exocytosis (GO:0016079)3.11721667
49establishment of integrated proviral latency (GO:0075713)3.08453222
50positive regulation of mitochondrial fission (GO:0090141)3.06370069
51negative regulation of meiotic cell cycle (GO:0051447)3.04268091
52presynaptic membrane organization (GO:0097090)3.03686404
53mitotic sister chromatid segregation (GO:0000070)3.03509302
54ribosome assembly (GO:0042255)3.03123925
55muscle cell migration (GO:0014812)3.02330202
56cell-substrate junction assembly (GO:0007044)3.02093522
57negative regulation of keratinocyte proliferation (GO:0010839)3.01619669
58neuron cell-cell adhesion (GO:0007158)3.00568404
59rRNA methylation (GO:0031167)3.00329760
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98854935
61regulation of metalloenzyme activity (GO:0048552)2.98527486
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97866358
63regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.97661573
64regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.97661573
65ventricular cardiac muscle cell development (GO:0055015)2.97067713
66type B pancreatic cell proliferation (GO:0044342)2.96422231
67regulation of water loss via skin (GO:0033561)2.95014332
68protein localization to synapse (GO:0035418)2.92564114
69chaperone-mediated protein transport (GO:0072321)2.92361856
70keratinocyte development (GO:0003334)2.92124824
71meiosis I (GO:0007127)2.89052653
72transferrin transport (GO:0033572)2.88894733
73regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88013951
747-methylguanosine mRNA capping (GO:0006370)2.87711184
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87332043
76response to histamine (GO:0034776)2.86994821
77positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.86958853
78regulation of synapse maturation (GO:0090128)2.84664333
79negative regulation of chondrocyte differentiation (GO:0032331)2.82931649
80establishment of viral latency (GO:0019043)2.81424385
81attachment of spindle microtubules to kinetochore (GO:0008608)2.80402927
82establishment of skin barrier (GO:0061436)2.80062005
83vocalization behavior (GO:0071625)2.78906679
84regulation of DNA methylation (GO:0044030)2.78223017
85RNA capping (GO:0036260)2.77570551
867-methylguanosine RNA capping (GO:0009452)2.77570551
87keratinization (GO:0031424)2.77462132
88cullin deneddylation (GO:0010388)2.76273850
89male meiosis (GO:0007140)2.74947447
90postsynaptic membrane organization (GO:0001941)2.74569695
91dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.74378149
92regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73613916
93regulation of translational termination (GO:0006449)2.73200976
94male meiosis I (GO:0007141)2.72390538
95negative regulation of stem cell proliferation (GO:2000647)2.71774296
96oocyte maturation (GO:0001556)2.71719248
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70432192
98behavioral response to cocaine (GO:0048148)2.68972793
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68360960
100regulation of sodium ion transmembrane transporter activity (GO:2000649)2.68212720
101ferric iron transport (GO:0015682)2.68155448
102trivalent inorganic cation transport (GO:0072512)2.68155448
103axonemal dynein complex assembly (GO:0070286)2.67282400
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67204176
105negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.66661275
106regulation of mitochondrial fission (GO:0090140)2.66531777
107cilium movement (GO:0003341)2.65380121
108keratinocyte proliferation (GO:0043616)2.64489844
109DNA replication checkpoint (GO:0000076)2.63250470
110positive regulation of neurotransmitter secretion (GO:0001956)2.63015687
111membrane raft organization (GO:0031579)2.62642775
112SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.61324506
113protein heterotrimerization (GO:0070208)2.60778501
114negative regulation of ligase activity (GO:0051352)2.59512001
115negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59512001
116protein localization to cilium (GO:0061512)2.59293009
117meiotic cell cycle (GO:0051321)2.58828572
118kidney mesenchyme development (GO:0072074)2.58574289
119regulation of glutamate receptor signaling pathway (GO:1900449)2.58551538
120notochord development (GO:0030903)2.58508635
121regulation of cellular amino acid metabolic process (GO:0006521)2.58437222
122positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57548710
123gap junction assembly (GO:0016264)2.57355890
124establishment of planar polarity (GO:0001736)2.57187187
125establishment of tissue polarity (GO:0007164)2.57187187
126intestinal epithelial cell development (GO:0060576)2.57146652
127neuron-neuron synaptic transmission (GO:0007270)2.55649053
128synaptic transmission, glutamatergic (GO:0035249)2.55401205
129neuronal action potential propagation (GO:0019227)2.55219332
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54871753
131wound healing, spreading of epidermal cells (GO:0035313)2.54735762
132peptidyl-proline hydroxylation (GO:0019511)2.54074572
133positive regulation of megakaryocyte differentiation (GO:0045654)2.52335826
134regulation of transforming growth factor beta2 production (GO:0032909)2.51089097
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50775869
136positive regulation of actin filament depolymerization (GO:0030836)2.50624621
137L-methionine salvage (GO:0071267)2.50530163
138L-methionine biosynthetic process (GO:0071265)2.50530163
139amino acid salvage (GO:0043102)2.50530163
140regulation of spindle organization (GO:0090224)2.50014588
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49992071
142regulation of cell maturation (GO:1903429)2.48763572
143protein K48-linked ubiquitination (GO:0070936)2.47887012
144regulation of cardioblast differentiation (GO:0051890)2.47768064
145negative regulation of dendrite morphogenesis (GO:0050774)2.47756480
146positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.47187710
147spindle checkpoint (GO:0031577)2.45686835
148positive regulation of chromosome segregation (GO:0051984)2.44680072
149endodermal cell differentiation (GO:0035987)2.44611944
150positive regulation of meiotic cell cycle (GO:0051446)2.44329520
151gamma-aminobutyric acid signaling pathway (GO:0007214)2.43510862
152collagen fibril organization (GO:0030199)2.43118769
153retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42555483
154protein localization to endosome (GO:0036010)2.42010667
155wound healing, spreading of cells (GO:0044319)2.41410242
156natural killer cell mediated immunity (GO:0002228)2.41024751
157natural killer cell mediated cytotoxicity (GO:0042267)2.41024751
158nucleotide-sugar biosynthetic process (GO:0009226)2.40144104
159protein hydroxylation (GO:0018126)2.39521737
160adherens junction assembly (GO:0034333)2.35518610
161cell-substrate adherens junction assembly (GO:0007045)2.34867843
162focal adhesion assembly (GO:0048041)2.34867843
163lipopolysaccharide biosynthetic process (GO:0009103)2.34169350
164barbed-end actin filament capping (GO:0051016)2.31918194
165L-serine transport (GO:0015825)2.30638022
166regulation of integrin-mediated signaling pathway (GO:2001044)2.30471261
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.30154057
168cellular copper ion homeostasis (GO:0006878)2.29228991
169DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.29027344
170regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.28270032
171basement membrane organization (GO:0071711)2.28080848
172extracellular fibril organization (GO:0043206)2.27620765
173signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.25942130
174intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.25942130
175atrioventricular valve morphogenesis (GO:0003181)2.25126858
176epithelial cell-cell adhesion (GO:0090136)2.25067502
177regulation of mitochondrial translation (GO:0070129)2.25058528
178cellular protein complex localization (GO:0034629)2.22467606
179negative regulation of cartilage development (GO:0061037)2.22432855
180chondrocyte proliferation (GO:0035988)2.22256003
181proline biosynthetic process (GO:0006561)2.21654499
182signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.20880675
183signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.20880675
184signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.20880675
185tRNA methylation (GO:0030488)2.20859136
186signal transduction involved in DNA damage checkpoint (GO:0072422)2.19844437
187signal transduction involved in DNA integrity checkpoint (GO:0072401)2.19844437
188GDP-mannose metabolic process (GO:0019673)2.19451235
189deoxyribonucleotide biosynthetic process (GO:0009263)2.19260070
190cochlea morphogenesis (GO:0090103)2.18407542
191positive regulation of ligase activity (GO:0051351)2.18009661
192mammary gland epithelial cell proliferation (GO:0033598)2.17600577
1934-hydroxyproline metabolic process (GO:0019471)2.16946313
194de novo posttranslational protein folding (GO:0051084)2.16752514
195de novo protein folding (GO:0006458)2.16549059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.79126732
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.49911316
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.64284621
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.30325616
5GBX2_23144817_ChIP-Seq_PC3_Human3.27105963
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.07451099
7E2F7_22180533_ChIP-Seq_HELA_Human2.99036472
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.94097286
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91450537
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.90134212
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83022527
12* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68063824
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66585827
14EZH2_22144423_ChIP-Seq_EOC_Human2.63958996
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.56551140
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54906775
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47787112
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47195265
19ZNF263_19887448_ChIP-Seq_K562_Human2.30313608
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28521531
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.21358986
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20020089
23DCP1A_22483619_ChIP-Seq_HELA_Human2.12245547
24KAP1_22055183_ChIP-Seq_ESCs_Mouse2.11870852
25CLOCK_20551151_ChIP-Seq_293T_Human2.03732961
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99999254
27* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.95639496
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95561440
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94402303
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92815430
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.87143366
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84609285
33* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84075262
34XRN2_22483619_ChIP-Seq_HELA_Human1.82458191
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82176112
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.81366310
37TAF15_26573619_Chip-Seq_HEK293_Human1.77322113
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.76885347
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76759121
40* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76414475
41* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76414475
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.75419836
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74362544
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74320259
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73239370
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69792700
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69372986
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65995803
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65802179
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65747865
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65234812
52VDR_22108803_ChIP-Seq_LS180_Human1.65145658
53* ATF3_27146783_Chip-Seq_COLON_Human1.65069705
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63155219
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62591327
56* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60065412
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57993453
58FUS_26573619_Chip-Seq_HEK293_Human1.57628583
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57409290
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.55201364
61GABP_19822575_ChIP-Seq_HepG2_Human1.53188019
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53152308
63REST_21632747_ChIP-Seq_MESCs_Mouse1.49854682
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49095551
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48215545
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45771462
67RNF2_27304074_Chip-Seq_NSC_Mouse1.44326402
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42467313
69* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41399584
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40042524
71LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38325826
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37129204
73TTF2_22483619_ChIP-Seq_HELA_Human1.35543211
74* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33001080
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.32580762
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.32422325
77* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31797431
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30946669
79* RARB_27405468_Chip-Seq_BRAIN_Mouse1.30877921
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30872159
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29153959
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28169770
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27567826
84TP53_22127205_ChIP-Seq_IMR90_Human1.26361497
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.26184915
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.26017879
87* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25533008
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25436073
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24825301
90* SMAD4_21799915_ChIP-Seq_A2780_Human1.24468054
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23362464
92* RACK7_27058665_Chip-Seq_MCF-7_Human1.23265933
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21909977
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21049414
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.20711908
96* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20442053
97AR_21909140_ChIP-Seq_LNCAP_Human1.19288105
98EST1_17652178_ChIP-ChIP_JURKAT_Human1.18448660
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18362262
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17484283
101* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16367297
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15757472
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15100662
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15031219
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14016540
106ELK1_19687146_ChIP-ChIP_HELA_Human1.13049876
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12498595
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12459056
109P300_19829295_ChIP-Seq_ESCs_Human1.12219449
110* BRD4_25478319_ChIP-Seq_HGPS_Human1.11672939
111* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11556599
112* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11494585
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10533789
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.10518208
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08965029
116SOX17_20123909_ChIP-Seq_XEN_Mouse1.08552356
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.08407461
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07276646
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07100569
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06797787
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06618509
122STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05760038
123TFEB_21752829_ChIP-Seq_HELA_Human1.04569632
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04557363
125EWS_26573619_Chip-Seq_HEK293_Human1.04507507
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.04452314
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04277403
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03324428
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03290479
130ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02363835
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01626437
132* STAT3_23295773_ChIP-Seq_U87_Human1.01200341
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00975424
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00801422
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00682362
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00513686
137* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00506174
138ETV1_20927104_ChIP-Seq_GIST48_Human1.00428239
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00114692
140JUN_21703547_ChIP-Seq_K562_Human0.99897934
141NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99508882
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99467701
143JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98712685
144MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98655627
145CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98553201
146MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98433672
147TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98378386
148AR_25329375_ChIP-Seq_VCAP_Human0.98066021
149KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97981523
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.97952981
151SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97654386
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97372919
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96040576
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95725090
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95725090
156SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93857225
157KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93557526
158NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92576186
159MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91995475
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.91822802
161MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91638110
162PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90547590
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90105412
164GATA3_21867929_ChIP-Seq_TH1_Mouse0.89946334
165E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89805322
166* EOMES_21245162_ChIP-Seq_HESCs_Human0.89223014
167NFE2_27457419_Chip-Seq_LIVER_Mouse0.88002380
168YY1_21170310_ChIP-Seq_MESCs_Mouse0.87655885
169SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87397735
170RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86264143
171SOX2_18555785_Chip-Seq_ESCs_Mouse0.86051256
172* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85982907
173TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85872876
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.85871596
175RBPJ_21746931_ChIP-Seq_IB4_Human0.85181705
176POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83447371
177* NANOG_16518401_ChIP-PET_MESCs_Mouse0.82868023
178SOX2_21211035_ChIP-Seq_LN229_Gbm0.82498938
179MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81725262
180CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81664630
181RNF2_27304074_Chip-Seq_ESCs_Mouse0.81183110
182FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81090258
183KAP1_27257070_Chip-Seq_ESCs_Mouse0.80076690
184NANOG_21062744_ChIP-ChIP_HESCs_Human0.80058620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.22232193
2MP0003880_abnormal_central_pattern4.05481185
3MP0004859_abnormal_synaptic_plasticity3.81545195
4MP0002653_abnormal_ependyma_morphology3.71833836
5MP0003718_maternal_effect3.59750428
6MP0003693_abnormal_embryo_hatching3.54042234
7MP0003705_abnormal_hypodermis_morpholog3.50070709
8MP0004272_abnormal_basement_membrane3.38749173
9MP0003646_muscle_fatigue3.26675484
10MP0003941_abnormal_skin_development3.22378462
11MP0003950_abnormal_plasma_membrane3.16626457
12MP0010030_abnormal_orbit_morphology2.88763607
13MP0003566_abnormal_cell_adhesion2.87822659
14MP0001984_abnormal_olfaction2.84012916
15MP0005275_abnormal_skin_tensile2.83220054
16MP0005623_abnormal_meninges_morphology2.71083189
17MP0005451_abnormal_body_composition2.69844586
18MP0002102_abnormal_ear_morphology2.47737212
19MP0004270_analgesia2.38724274
20MP0008260_abnormal_autophagy2.37287964
21MP0003635_abnormal_synaptic_transmissio2.34702330
22MP0008877_abnormal_DNA_methylation2.29656766
23MP0009053_abnormal_anal_canal2.29294076
24MP0005257_abnormal_intraocular_pressure2.23816456
25MP0003879_abnormal_hair_cell2.18641144
26MP0003123_paternal_imprinting2.15567727
27MP0000762_abnormal_tongue_morphology2.14444193
28MP0005501_abnormal_skin_physiology2.14060639
29MP0002060_abnormal_skin_morphology2.12648546
30MP0001968_abnormal_touch/_nociception2.07765284
31MP0002063_abnormal_learning/memory/cond2.05044227
32MP0004957_abnormal_blastocyst_morpholog2.02290853
33MP0003111_abnormal_nucleus_morphology2.01466855
34MP0003279_aneurysm1.97878786
35MP0002736_abnormal_nociception_after1.96246962
36MP0009046_muscle_twitch1.93249786
37MP0009745_abnormal_behavioral_response1.90664844
38MP0010368_abnormal_lymphatic_system1.87830601
39MP0005023_abnormal_wound_healing1.83812601
40MP0005503_abnormal_tendon_morphology1.82487700
41MP0002734_abnormal_mechanical_nocicepti1.82127526
42MP0006054_spinal_hemorrhage1.79084449
43MP0002877_abnormal_melanocyte_morpholog1.78369911
44MP0001958_emphysema1.76575988
45MP0002572_abnormal_emotion/affect_behav1.74476616
46MP0010234_abnormal_vibrissa_follicle1.71607328
47MP0002064_seizures1.68253420
48MP0009384_cardiac_valve_regurgitation1.63588749
49MP0005646_abnormal_pituitary_gland1.62010682
50MP0003787_abnormal_imprinting1.61003353
51MP0005395_other_phenotype1.60067010
52MP0000467_abnormal_esophagus_morphology1.58612701
53MP0001529_abnormal_vocalization1.58017454
54MP0003191_abnormal_cellular_cholesterol1.52544198
55MP0003806_abnormal_nucleotide_metabolis1.49653641
56MP0001849_ear_inflammation1.44225185
57MP0001216_abnormal_epidermal_layer1.43037723
58MP0005508_abnormal_skeleton_morphology1.42860275
59MP0001905_abnormal_dopamine_level1.41880612
60MP0002234_abnormal_pharynx_morphology1.40977498
61MP0006292_abnormal_olfactory_placode1.40841815
62MP0003315_abnormal_perineum_morphology1.40010635
63MP0001440_abnormal_grooming_behavior1.38840558
64MP0003186_abnormal_redox_activity1.38655736
65MP0001243_abnormal_dermal_layer1.37194105
66MP0002272_abnormal_nervous_system1.36061591
67MP0000579_abnormal_nail_morphology1.36013260
68MP0003077_abnormal_cell_cycle1.32486215
69MP0010771_integument_phenotype1.32338479
70MP0003453_abnormal_keratinocyte_physiol1.32273184
71MP0002160_abnormal_reproductive_system1.31714981
72MP0010352_gastrointestinal_tract_polyps1.31287085
73MP0002282_abnormal_trachea_morphology1.31163283
74MP0010094_abnormal_chromosome_stability1.28903325
75MP0001501_abnormal_sleep_pattern1.28528029
76MP0001299_abnormal_eye_distance/1.27085498
77MP0008004_abnormal_stomach_pH1.23778500
78MP0008932_abnormal_embryonic_tissue1.20691884
79MP0000751_myopathy1.18876955
80MP0002067_abnormal_sensory_capabilities1.17278991
81MP0002184_abnormal_innervation1.17276714
82MP0000537_abnormal_urethra_morphology1.15446323
83MP0003091_abnormal_cell_migration1.14980503
84MP0001119_abnormal_female_reproductive1.14743787
85MP0001929_abnormal_gametogenesis1.14309616
86MP0003699_abnormal_female_reproductive1.14046982
87MP0002876_abnormal_thyroid_physiology1.13495963
88MP0001188_hyperpigmentation1.13290958
89MP0002210_abnormal_sex_determination1.12848431
90MP0000647_abnormal_sebaceous_gland1.12417000
91MP0004233_abnormal_muscle_weight1.11526390
92MP0002098_abnormal_vibrissa_morphology1.11471647
93MP0009250_abnormal_appendicular_skeleto1.10741427
94MP0002735_abnormal_chemical_nociception1.09822053
95MP0005389_reproductive_system_phenotype1.09190376
96MP0000653_abnormal_sex_gland1.07833632
97MP0000767_abnormal_smooth_muscle1.07299572
98MP0003942_abnormal_urinary_system1.04416259
99MP0000427_abnormal_hair_cycle1.04386757
100MP0004145_abnormal_muscle_electrophysio1.04279121
101MP0004484_altered_response_of1.03803133
102MP0000733_abnormal_muscle_development1.03146532
103MP0003937_abnormal_limbs/digits/tail_de1.03043368
104MP0001502_abnormal_circadian_rhythm1.02902907
105MP0005197_abnormal_uvea_morphology1.02883662
106MP0000749_muscle_degeneration1.02817639
107MP0001486_abnormal_startle_reflex1.01988055
108MP0002295_abnormal_pulmonary_circulatio1.01803318
109MP0000534_abnormal_ureter_morphology1.01542496
110MP0003385_abnormal_body_wall1.01509025
111MP0001970_abnormal_pain_threshold1.01037881
112MP0003755_abnormal_palate_morphology1.01005987
113MP0000778_abnormal_nervous_system1.00617048
114MP0004924_abnormal_behavior0.98622183
115MP0005386_behavior/neurological_phenoty0.98622183
116MP0001919_abnormal_reproductive_system0.98416908
117MP0000358_abnormal_cell_content/0.98323158
118MP0003786_premature_aging0.96657908
119MP0001485_abnormal_pinna_reflex0.95093494
120MP0000003_abnormal_adipose_tissue0.93231746
121MP0003329_amyloid_beta_deposits0.92855402
122MP0000750_abnormal_muscle_regeneration0.92435632
123MP0000377_abnormal_hair_follicle0.89999580
124MP0010678_abnormal_skin_adnexa0.88947545
125MP0002796_impaired_skin_barrier0.87593130
126MP0005165_increased_susceptibility_to0.87564553
127MP0002161_abnormal_fertility/fecundity0.86168061
128MP0000678_abnormal_parathyroid_gland0.86114675
129MP0008058_abnormal_DNA_repair0.85403349
130MP0000627_abnormal_mammary_gland0.85368197
131MP0002177_abnormal_outer_ear0.85251396
132MP0002697_abnormal_eye_size0.85037439
133MP0002896_abnormal_bone_mineralization0.84568874
134MP0000013_abnormal_adipose_tissue0.83304143
135MP0003938_abnormal_ear_development0.82943155
136MP0009697_abnormal_copulation0.82166407
137MP0010386_abnormal_urinary_bladder0.81953981
138MP0001881_abnormal_mammary_gland0.81211172
139MP0001145_abnormal_male_reproductive0.81102982
140MP0002233_abnormal_nose_morphology0.81010784
141MP0009780_abnormal_chondrocyte_physiolo0.80938679
142MP0000049_abnormal_middle_ear0.80336724
143MP0001542_abnormal_bone_strength0.79708807
144MP0000759_abnormal_skeletal_muscle0.77799779
145MP0004264_abnormal_extraembryonic_tissu0.77289823
146MP0009840_abnormal_foam_cell0.77115439
147MP0005193_abnormal_anterior_eye0.76925907
148MP0000858_altered_metastatic_potential0.76416183
149MP0003121_genomic_imprinting0.74806344
150MP0001730_embryonic_growth_arrest0.73852788
151MP0001340_abnormal_eyelid_morphology0.73465229
152MP0002111_abnormal_tail_morphology0.72970956
153MP0001963_abnormal_hearing_physiology0.72088498
154MP0002066_abnormal_motor_capabilities/c0.71964017
155MP0005499_abnormal_olfactory_system0.71917513
156MP0005394_taste/olfaction_phenotype0.71917513
157MP0002557_abnormal_social/conspecific_i0.71792315
158MP0002085_abnormal_embryonic_tissue0.71782843
159MP0004185_abnormal_adipocyte_glucose0.71599936
160MP0002152_abnormal_brain_morphology0.71306873
161MP0002882_abnormal_neuron_morphology0.70624043
162MP0002080_prenatal_lethality0.70583809
163MP0003698_abnormal_male_reproductive0.69981437
164MP0002084_abnormal_developmental_patter0.69407057
165MP0008007_abnormal_cellular_replicative0.67202004
166MP0002733_abnormal_thermal_nociception0.65806590
167MP0003861_abnormal_nervous_system0.65424170
168MP0008789_abnormal_olfactory_epithelium0.65219743
169MP0003136_yellow_coat_color0.65014959
170MP0000350_abnormal_cell_proliferation0.63016094
171MP0003632_abnormal_nervous_system0.62773998
172MP0002752_abnormal_somatic_nervous0.61915312
173MP0001672_abnormal_embryogenesis/_devel0.61704064
174MP0005380_embryogenesis_phenotype0.61704064
175MP0001697_abnormal_embryo_size0.61611347

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.07490726
2Focal motor seizures (HP:0011153)5.89078678
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.83027831
4Birth length less than 3rd percentile (HP:0003561)4.70486937
5Protrusio acetabuli (HP:0003179)4.65826891
6Breast hypoplasia (HP:0003187)4.32315209
7Atonic seizures (HP:0010819)4.22454181
8Epileptic encephalopathy (HP:0200134)3.88733730
9Abnormality of the labia minora (HP:0012880)3.84864264
10Atrophic scars (HP:0001075)3.71407661
11Abnormal respiratory motile cilium physiology (HP:0012261)3.70016353
12Ankle contracture (HP:0006466)3.67304354
13Male infertility (HP:0003251)3.55051984
14Follicular hyperkeratosis (HP:0007502)3.48017698
15Irregular epiphyses (HP:0010582)3.41845132
16Pancreatic fibrosis (HP:0100732)3.40323605
17Hyperventilation (HP:0002883)3.39576092
18Rhinitis (HP:0012384)3.37955423
19Onycholysis (HP:0001806)3.37181884
20Abnormality of nail color (HP:0100643)3.27106380
21Febrile seizures (HP:0002373)3.22469050
22Spinal rigidity (HP:0003306)3.20427053
23Vertebral compression fractures (HP:0002953)3.10742276
24Chronic bronchitis (HP:0004469)3.10738898
25Abnormality of dentin (HP:0010299)3.09707216
26Flat capital femoral epiphysis (HP:0003370)3.06072255
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.04022707
28Abnormality of alanine metabolism (HP:0010916)3.04022707
29Hyperalaninemia (HP:0003348)3.04022707
30Vascular tortuosity (HP:0004948)2.96148218
31Fragile skin (HP:0001030)2.96101372
32Abnormal ciliary motility (HP:0012262)2.94178512
33Breast aplasia (HP:0100783)2.93521060
34Aplasia/Hypoplasia of the breasts (HP:0010311)2.90045461
35Focal seizures (HP:0007359)2.88791346
36Natal tooth (HP:0000695)2.86233987
37Reduced subcutaneous adipose tissue (HP:0003758)2.84752256
38Entropion (HP:0000621)2.82820246
39Myokymia (HP:0002411)2.82461438
40Fragile nails (HP:0001808)2.81593156
41Patellar aplasia (HP:0006443)2.76514021
42Abnormality of the umbilical cord (HP:0010881)2.75895552
43Abnormality of the distal phalanges of the toes (HP:0010182)2.73421267
44Absence seizures (HP:0002121)2.71154418
45Dialeptic seizures (HP:0011146)2.70189157
46Aortic dissection (HP:0002647)2.69561666
47Arterial tortuosity (HP:0005116)2.68231343
48Aplasia/Hypoplasia of the patella (HP:0006498)2.67160085
49Carpal bone hypoplasia (HP:0001498)2.66392504
50Adrenal hypoplasia (HP:0000835)2.64951182
51Distal lower limb muscle weakness (HP:0009053)2.62886904
52Achilles tendon contracture (HP:0001771)2.62846059
53Premature ovarian failure (HP:0008209)2.60008237
54Poor coordination (HP:0002370)2.56606415
55Elbow flexion contracture (HP:0002987)2.56355866
56Cervical subluxation (HP:0003308)2.55119179
57Secondary amenorrhea (HP:0000869)2.54902344
58Broad-based gait (HP:0002136)2.54438221
59Trismus (HP:0000211)2.52172859
60Pancreatic cysts (HP:0001737)2.51845926
61Short nail (HP:0001799)2.50314710
62Selective tooth agenesis (HP:0001592)2.49566493
63Bladder diverticulum (HP:0000015)2.48990265
64Abnormalities of placenta or umbilical cord (HP:0001194)2.48773185
65Gait imbalance (HP:0002141)2.48693708
66Congenital ichthyosiform erythroderma (HP:0007431)2.48176120
67Sparse eyelashes (HP:0000653)2.47646073
68Congenital primary aphakia (HP:0007707)2.47628167
69Osteolytic defects of the hand bones (HP:0009699)2.47426635
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.47426635
71Fetal akinesia sequence (HP:0001989)2.46980767
72Soft skin (HP:0000977)2.46254030
73Cerebral hypomyelination (HP:0006808)2.46238538
74Delusions (HP:0000746)2.44116432
75Thick nail (HP:0001805)2.38690754
76Plantar hyperkeratosis (HP:0007556)2.35579096
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.35201407
78Aortic aneurysm (HP:0004942)2.32629813
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30135728
80Medial flaring of the eyebrow (HP:0010747)2.29987445
81Wormian bones (HP:0002645)2.29525968
82Pterygium (HP:0001059)2.29517957
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29426246
84Nail dystrophy (HP:0008404)2.28521245
85Abnormality of the Achilles tendon (HP:0005109)2.26960655
86Nephrogenic diabetes insipidus (HP:0009806)2.25924089
87Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.25054218
88Absent epiphyses (HP:0010577)2.25054218
89True hermaphroditism (HP:0010459)2.23105683
90Abnormal respiratory motile cilium morphology (HP:0005938)2.17140378
91Abnormal respiratory epithelium morphology (HP:0012253)2.17140378
92Abnormal umbilical cord blood vessels (HP:0011403)2.16748362
93Single umbilical artery (HP:0001195)2.16748362
94Abnormality of the fetal cardiovascular system (HP:0010948)2.16748362
95Upper limb amyotrophy (HP:0009129)2.13019599
96Distal upper limb amyotrophy (HP:0007149)2.13019599
97Molar tooth sign on MRI (HP:0002419)2.12645570
98Abnormality of midbrain morphology (HP:0002418)2.12645570
99Abnormality of placental membranes (HP:0011409)2.11812759
100Amniotic constriction ring (HP:0009775)2.11812759
101Generalized amyotrophy (HP:0003700)2.10919907
102Infertility (HP:0000789)2.10883416
103Shawl scrotum (HP:0000049)2.09921961
104Palmoplantar hyperkeratosis (HP:0000972)2.09123002
105Alopecia of scalp (HP:0002293)2.09100543
106Nonprogressive disorder (HP:0003680)2.08754657
107Abnormality of the epiphysis of the femoral head (HP:0010574)2.07881323
108Limb-girdle muscle atrophy (HP:0003797)2.06688241
109Hydroureter (HP:0000072)2.01788144
110Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.01090580
111Abnormality of femoral epiphyses (HP:0006499)2.01090580
112Milia (HP:0001056)2.00240305
113Generalized tonic-clonic seizures (HP:0002069)2.00002316
114Unsteady gait (HP:0002317)1.98970370
115Cardiovascular calcification (HP:0011915)1.97794220
116Slow-growing hair (HP:0002217)1.97340824
117Abnormality of hair growth rate (HP:0011363)1.97340824
118Papillary thyroid carcinoma (HP:0002895)1.96706854
119Mitral stenosis (HP:0001718)1.96581274
120Upper limb muscle weakness (HP:0003484)1.94857521
121Hand muscle atrophy (HP:0009130)1.94302281
122Brittle hair (HP:0002299)1.93675678
123Blue sclerae (HP:0000592)1.92308835
124Abnormality of the acetabulum (HP:0003170)1.91459425
125Abnormal hair whorl (HP:0010721)1.90867635
126Redundant skin (HP:0001582)1.90843344
127Abnormal delivery (HP:0001787)1.90780243
128Ulnar bowing (HP:0003031)1.90018840
129Palmar hyperkeratosis (HP:0010765)1.89491931
130Mildly elevated creatine phosphokinase (HP:0008180)1.88516655
131Delayed gross motor development (HP:0002194)1.88408333
132Acanthosis nigricans (HP:0000956)1.88347575
133Abnormality of carpal bone ossification (HP:0006257)1.87134528
134Abnormality of the femoral head (HP:0003368)1.85640382
135Genu varum (HP:0002970)1.83543659
136Oligodactyly (hands) (HP:0001180)1.83463489
137Glucose intolerance (HP:0000833)1.82304095
138Inability to walk (HP:0002540)1.80622768
139Pili torti (HP:0003777)1.80223098
140Abnormality of the proximal phalanges of the hand (HP:0009834)1.80122366
141Abnormal trabecular bone morphology (HP:0100671)1.79264149
142Cholecystitis (HP:0001082)1.79175992
143Abnormal gallbladder physiology (HP:0012438)1.79175992
144Dilatation of the ascending aorta (HP:0005111)1.78962327
145Abnormality of the labia (HP:0000058)1.76891610
146Popliteal pterygium (HP:0009756)1.76816493
147Rough bone trabeculation (HP:0100670)1.75461112
148Shoulder girdle muscle weakness (HP:0003547)1.75016226
149Capillary hemangiomas (HP:0005306)1.74084869
150Increased connective tissue (HP:0009025)1.73458404
151Distal lower limb amyotrophy (HP:0008944)1.73442831
152Genital tract atresia (HP:0001827)1.73264689
153Amblyopia (HP:0000646)1.72579522
154Curly hair (HP:0002212)1.71671716
155Aplasia/Hypoplasia involving the musculature (HP:0001460)1.71062221
156Spastic diplegia (HP:0001264)1.70921738
157Spinal cord compression (HP:0002176)1.70612966
158CNS hypomyelination (HP:0003429)1.70157756
159Knee flexion contracture (HP:0006380)1.69540843
160Occipital encephalocele (HP:0002085)1.69380886
161Hypokinesia (HP:0002375)1.69308055
162Oral leukoplakia (HP:0002745)1.69265047
163Neonatal short-limb short stature (HP:0008921)1.69184800
164Short clavicles (HP:0000894)1.69147014
165Right ventricular cardiomyopathy (HP:0011663)1.68910803
166Increased serum pyruvate (HP:0003542)1.68729458
167Absent radius (HP:0003974)1.67998946
168Fibular aplasia (HP:0002990)1.67932934
169Difficulty climbing stairs (HP:0003551)1.67868858
170Atelectasis (HP:0100750)1.67391801
171Breech presentation (HP:0001623)1.66846400
172Abnormality of glycolysis (HP:0004366)1.66546608
173Abnormal eating behavior (HP:0100738)1.66451183
174Type 1 muscle fiber predominance (HP:0003803)1.66142161
175Vaginal atresia (HP:0000148)1.65765515
176Advanced eruption of teeth (HP:0006288)1.64860328
177Sparse lateral eyebrow (HP:0005338)1.64840103
178Limb-girdle muscle weakness (HP:0003325)1.64589014
179Aplasia/Hypoplasia of the sternum (HP:0006714)1.64301640
180Hypotrichosis (HP:0001006)1.63955194
181Cystic hygroma (HP:0000476)1.63392660
182Hypoplastic female external genitalia (HP:0012815)1.60801950
183Aplasia involving forearm bones (HP:0009822)1.60556421
184Absent forearm bone (HP:0003953)1.60556421
185Gaze-evoked nystagmus (HP:0000640)1.60123170
186Oligodactyly (HP:0012165)1.59377409
187Broad foot (HP:0001769)1.59273396
188Dysmetric saccades (HP:0000641)1.59041197
189Aplasia/Hypoplasia of the tongue (HP:0010295)1.58959043
190Insulin-resistant diabetes mellitus (HP:0000831)1.58406360
191Median cleft lip (HP:0000161)1.57464791
192Nephronophthisis (HP:0000090)1.57217998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.45402576
2TESK13.17640117
3NME23.05174039
4ARAF2.82899630
5VRK22.79168442
6MAP3K92.77667476
7STK38L2.77350399
8EPHA42.75202487
9BUB12.62814640
10PBK2.55010389
11AKT32.51423827
12LATS22.50832599
13EPHA22.49893436
14CCNB12.45082634
15BRAF2.43745417
16PIM22.39758160
17LIMK12.38744277
18BMPR22.36408371
19MYLK2.32098101
20MST1R2.28679780
21TAOK12.25592803
22PLK42.24840175
23PAK42.18667730
24MAP3K62.13636389
25DAPK22.09213340
26MET2.08070446
27LATS12.03898243
28PTK21.96774108
29MOS1.94573549
30KSR21.93067161
31TESK21.90170541
32IRAK31.85956216
33PLK21.85636041
34MAP2K71.85495313
35MAP3K121.83919829
36MAP3K41.78178633
37TTK1.67340316
38MST41.66073010
39STK161.64128806
40CDK191.62495045
41KSR11.62322388
42EPHB21.59202558
43RAF11.55974795
44DAPK11.55460114
45PAK61.49060134
46SMG11.48228521
47TSSK61.45061614
48CAMKK21.42565961
49PDGFRA1.40056491
50PAK21.35846430
51WEE11.34015371
52PRPF4B1.28166683
53NTRK31.25547741
54MAP3K31.24652287
55MUSK1.19346442
56ERBB41.14528573
57NEK91.11375652
58PNCK1.09612488
59NTRK11.08845933
60ILK1.06575677
61MAP3K131.05141584
62NEK11.04894521
63CDK81.02921398
64PLK31.01213440
65SCYL21.01079833
66DAPK30.99517773
67MAP2K40.98613727
68MAPKAPK30.97808909
69CDK30.93766712
70SGK20.92527039
71TTN0.91208276
72STK100.90798187
73FLT30.90170056
74MAPK130.88535349
75PLK10.88533892
76LMTK20.88292984
77NME10.86272857
78OXSR10.85946392
79EIF2AK30.84353971
80STK380.83870063
81PRKCI0.81781160
82STK240.81153356
83BRSK10.80644517
84BRSK20.77626579
85DYRK20.77260857
86MAP3K80.76180664
87TGFBR20.76131253
88PDK40.75287379
89PDK30.75287379
90MAPK150.74263310
91CAMK2A0.74141473
92SGK2230.73949662
93SGK4940.73949662
94CDK70.73807804
95CHEK20.73281821
96VRK10.71847442
97DDR20.71285767
98CDC70.70508834
99SIK10.67784434
100AURKA0.66793318
101CAMK2B0.66432379
102CAMKK10.64670397
103SRPK10.64274079
104ABL20.63025659
105BCKDK0.62934443
106PRKD30.62817258
107PRKCG0.61245599
108CDK180.61170337
109LRRK20.59015424
110KDR0.58653400
111PINK10.57934639
112NEK20.57752317
113CDK150.57145576
114MELK0.56871828
115STK30.55912662
116ROCK20.55799479
117MARK10.55615658
118ERN10.55013577
119EIF2AK10.53976250
120CDK90.53897597
121MAP3K50.53739011
122CDK11A0.49015228
123AKT20.48705455
124TAOK20.47983225
125ICK0.47340648
126GRK50.46984921
127CDK140.46040357
128CDK120.44983659
129PDK20.44449541
130ROCK10.43587724
131DMPK0.43574167
132STK110.43397595
133CSNK1G20.43233215
134MKNK20.42634141
135PRKD20.42327017
136RIPK10.42117027
137BMX0.41229430
138BCR0.40730433
139GSK3A0.40680583
140SGK30.40644257
141CAMK2G0.39165515
142MAP2K10.38617288
143TAF10.38540732
144PAK10.37858834
145TRIB30.36449100
146TYRO30.36336039
147FER0.35480660
148CSNK1G10.34191324
149AURKB0.33807810
150CDK50.33425230
151PTK2B0.33355395
152RPS6KA40.30197666
153NTRK20.28061801
154MINK10.27967921

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.51288853
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27828619
3Collecting duct acid secretion_Homo sapiens_hsa049662.89286278
4Nicotine addiction_Homo sapiens_hsa050332.89107139
5Circadian rhythm_Homo sapiens_hsa047102.75113404
6Vitamin B6 metabolism_Homo sapiens_hsa007502.69697277
7RNA polymerase_Homo sapiens_hsa030202.36976434
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.35816372
9DNA replication_Homo sapiens_hsa030302.32983316
10Oocyte meiosis_Homo sapiens_hsa041142.16868029
11Amphetamine addiction_Homo sapiens_hsa050312.14992097
12Long-term potentiation_Homo sapiens_hsa047202.12971686
13Proteasome_Homo sapiens_hsa030502.12097839
14Basal transcription factors_Homo sapiens_hsa030222.09641244
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06512445
16Cell cycle_Homo sapiens_hsa041102.03552571
17Fatty acid elongation_Homo sapiens_hsa000621.97242062
18Mismatch repair_Homo sapiens_hsa034301.96733147
19Regulation of autophagy_Homo sapiens_hsa041401.96420950
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94438412
21ECM-receptor interaction_Homo sapiens_hsa045121.92451106
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89857964
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86417257
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86253123
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83095963
26Sulfur relay system_Homo sapiens_hsa041221.79407606
27Biosynthesis of amino acids_Homo sapiens_hsa012301.70437005
28Glutathione metabolism_Homo sapiens_hsa004801.66944764
29Vibrio cholerae infection_Homo sapiens_hsa051101.66807863
30Glutamatergic synapse_Homo sapiens_hsa047241.66296704
31Ribosome_Homo sapiens_hsa030101.62539537
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59976280
33Base excision repair_Homo sapiens_hsa034101.59717663
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58736329
35Circadian entrainment_Homo sapiens_hsa047131.56214241
36RNA transport_Homo sapiens_hsa030131.49568638
37Pentose phosphate pathway_Homo sapiens_hsa000301.49052684
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48237533
39Morphine addiction_Homo sapiens_hsa050321.47538393
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47326520
41Sulfur metabolism_Homo sapiens_hsa009201.44644351
42Dopaminergic synapse_Homo sapiens_hsa047281.44279287
43Pyruvate metabolism_Homo sapiens_hsa006201.43893236
44GnRH signaling pathway_Homo sapiens_hsa049121.42975435
45N-Glycan biosynthesis_Homo sapiens_hsa005101.42099210
46Ovarian steroidogenesis_Homo sapiens_hsa049131.40965446
47Carbon metabolism_Homo sapiens_hsa012001.37248755
48GABAergic synapse_Homo sapiens_hsa047271.33348370
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32309714
50RNA degradation_Homo sapiens_hsa030181.28411822
51Focal adhesion_Homo sapiens_hsa045101.25813489
52Long-term depression_Homo sapiens_hsa047301.25214210
53Oxytocin signaling pathway_Homo sapiens_hsa049211.23868944
54Folate biosynthesis_Homo sapiens_hsa007901.21814181
55Steroid biosynthesis_Homo sapiens_hsa001001.21380290
56Insulin secretion_Homo sapiens_hsa049111.18677641
57Salivary secretion_Homo sapiens_hsa049701.17830432
58Serotonergic synapse_Homo sapiens_hsa047261.17773016
59Phototransduction_Homo sapiens_hsa047441.15248408
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13432305
61Taste transduction_Homo sapiens_hsa047421.13306807
62Galactose metabolism_Homo sapiens_hsa000521.12615050
63Spliceosome_Homo sapiens_hsa030401.11159610
64Proteoglycans in cancer_Homo sapiens_hsa052051.09640256
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.07839685
66Adherens junction_Homo sapiens_hsa045201.06892460
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02759517
68Phenylalanine metabolism_Homo sapiens_hsa003601.02505783
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02354154
70Purine metabolism_Homo sapiens_hsa002301.00551296
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.98340859
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98126594
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96909678
74Parkinsons disease_Homo sapiens_hsa050120.96609553
75Small cell lung cancer_Homo sapiens_hsa052220.96318978
76Hippo signaling pathway_Homo sapiens_hsa043900.94993315
77Basal cell carcinoma_Homo sapiens_hsa052170.93322695
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93083606
79Protein export_Homo sapiens_hsa030600.92576417
80Calcium signaling pathway_Homo sapiens_hsa040200.89453650
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.88595143
82One carbon pool by folate_Homo sapiens_hsa006700.87835215
83Gap junction_Homo sapiens_hsa045400.87785411
84Shigellosis_Homo sapiens_hsa051310.87085760
85Cocaine addiction_Homo sapiens_hsa050300.86900228
86ErbB signaling pathway_Homo sapiens_hsa040120.84910728
87Thyroid cancer_Homo sapiens_hsa052160.84571838
88p53 signaling pathway_Homo sapiens_hsa041150.81799153
89Cholinergic synapse_Homo sapiens_hsa047250.81782572
90Rheumatoid arthritis_Homo sapiens_hsa053230.80876033
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80669309
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.78087602
93Ether lipid metabolism_Homo sapiens_hsa005650.78069341
94Tyrosine metabolism_Homo sapiens_hsa003500.77928834
95Estrogen signaling pathway_Homo sapiens_hsa049150.77913136
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77456566
97Melanogenesis_Homo sapiens_hsa049160.77096150
98Gastric acid secretion_Homo sapiens_hsa049710.76652848
99Fanconi anemia pathway_Homo sapiens_hsa034600.76571004
100Pyrimidine metabolism_Homo sapiens_hsa002400.75679706
101Tight junction_Homo sapiens_hsa045300.75199976
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75125869
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73602101
104cAMP signaling pathway_Homo sapiens_hsa040240.73535797
105Renal cell carcinoma_Homo sapiens_hsa052110.69851358
106Huntingtons disease_Homo sapiens_hsa050160.69747324
107Renin secretion_Homo sapiens_hsa049240.69478798
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69131275
109Hedgehog signaling pathway_Homo sapiens_hsa043400.68626840
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.68374495
111MAPK signaling pathway_Homo sapiens_hsa040100.67977217
112Alzheimers disease_Homo sapiens_hsa050100.67671908
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67660948
114TGF-beta signaling pathway_Homo sapiens_hsa043500.67659206
115Linoleic acid metabolism_Homo sapiens_hsa005910.65929909
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65415147
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65326862
118Choline metabolism in cancer_Homo sapiens_hsa052310.65082444
119Glioma_Homo sapiens_hsa052140.64318187
120Nucleotide excision repair_Homo sapiens_hsa034200.63286319
121Ras signaling pathway_Homo sapiens_hsa040140.62553079
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62171867
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61466485
124Non-homologous end-joining_Homo sapiens_hsa034500.61091365
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61061117
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60564901
127mRNA surveillance pathway_Homo sapiens_hsa030150.60456463
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59622637
129MicroRNAs in cancer_Homo sapiens_hsa052060.58496764
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57710845
131Arginine and proline metabolism_Homo sapiens_hsa003300.57553210
132Sphingolipid metabolism_Homo sapiens_hsa006000.57065787
133Arachidonic acid metabolism_Homo sapiens_hsa005900.57011116
134Metabolic pathways_Homo sapiens_hsa011000.55240470
135Epstein-Barr virus infection_Homo sapiens_hsa051690.54576789
136FoxO signaling pathway_Homo sapiens_hsa040680.54487867
137Wnt signaling pathway_Homo sapiens_hsa043100.54433671
138Prion diseases_Homo sapiens_hsa050200.52390112
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51803149
140mTOR signaling pathway_Homo sapiens_hsa041500.51716641
141Oxidative phosphorylation_Homo sapiens_hsa001900.50734806
142Other glycan degradation_Homo sapiens_hsa005110.49848023
143Inositol phosphate metabolism_Homo sapiens_hsa005620.49681851
144Dilated cardiomyopathy_Homo sapiens_hsa054140.49017957
145Homologous recombination_Homo sapiens_hsa034400.48739029
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48291251
147VEGF signaling pathway_Homo sapiens_hsa043700.47023561
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46290488
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45843335
150Lysosome_Homo sapiens_hsa041420.44564948
151Amoebiasis_Homo sapiens_hsa051460.44356010
152Axon guidance_Homo sapiens_hsa043600.43198863
153Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42814920
154Apoptosis_Homo sapiens_hsa042100.40763266
155Pathways in cancer_Homo sapiens_hsa052000.40625133
156Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40506992
157Colorectal cancer_Homo sapiens_hsa052100.40373389
158Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40305371
159Fructose and mannose metabolism_Homo sapiens_hsa000510.39735138
160Pancreatic cancer_Homo sapiens_hsa052120.39206148
161Endocytosis_Homo sapiens_hsa041440.39032691
162Selenocompound metabolism_Homo sapiens_hsa004500.38775393
163Endometrial cancer_Homo sapiens_hsa052130.38111003
164Bladder cancer_Homo sapiens_hsa052190.37818312
165Melanoma_Homo sapiens_hsa052180.36776966
166Prolactin signaling pathway_Homo sapiens_hsa049170.36619014
167Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34969288
168Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31829601

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