DUSP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.40550235
2central nervous system myelination (GO:0022010)6.71134928
3axon ensheathment in central nervous system (GO:0032291)6.71134928
4spermatid nucleus differentiation (GO:0007289)6.48622753
5protein polyglutamylation (GO:0018095)6.48185081
6spermatid development (GO:0007286)6.41515419
7single strand break repair (GO:0000012)5.97325873
8chromosome condensation (GO:0030261)5.84688972
9DNA packaging (GO:0006323)5.79243269
10axon ensheathment (GO:0008366)5.42398631
11ensheathment of neurons (GO:0007272)5.42398631
12sperm-egg recognition (GO:0035036)5.33743911
13microtubule depolymerization (GO:0007019)5.26644404
14sexual reproduction (GO:0019953)5.23951570
15microtubule severing (GO:0051013)5.19906156
16myelination (GO:0042552)5.18048255
17binding of sperm to zona pellucida (GO:0007339)5.04745117
18phosphatidylethanolamine biosynthetic process (GO:0006646)4.99347789
19neuronal action potential propagation (GO:0019227)4.96467333
20regulation of cilium movement (GO:0003352)4.91809185
21protein targeting to Golgi (GO:0000042)4.84633178
22cellular ketone body metabolic process (GO:0046950)4.70845010
23phosphatidylethanolamine metabolic process (GO:0046337)4.67890578
24reproduction (GO:0000003)4.67242190
25rRNA methylation (GO:0031167)4.66375129
26establishment of protein localization to Golgi (GO:0072600)4.65522617
27spermatogenesis (GO:0007283)4.60618884
28male gamete generation (GO:0048232)4.58508133
29fatty acid elongation (GO:0030497)4.58233261
30microtubule polymerization or depolymerization (GO:0031109)4.57852517
31acrosome reaction (GO:0007340)4.48691320
32retrograde transport, vesicle recycling within Golgi (GO:0000301)4.47423741
33regulation of microtubule-based movement (GO:0060632)4.28045761
34regulation of transcription involved in cell fate commitment (GO:0060850)4.27861665
35cell-cell recognition (GO:0009988)4.25831138
36ketone body metabolic process (GO:1902224)4.22600637
37gamete generation (GO:0007276)4.18085354
38synaptic vesicle maturation (GO:0016188)4.05630243
39L-amino acid import (GO:0043092)4.05011677
40cranial nerve morphogenesis (GO:0021602)3.98715569
41long-chain fatty acid biosynthetic process (GO:0042759)3.93417130
42epithelial cilium movement (GO:0003351)3.92949103
43metanephric nephron tubule development (GO:0072234)3.91851477
44metanephric tubule development (GO:0072170)3.91851477
45regulation of secondary heart field cardioblast proliferation (GO:0003266)3.90902295
46regulation of cardioblast proliferation (GO:0003264)3.90902295
47peptidyl-tyrosine autophosphorylation (GO:0038083)3.89281376
48rRNA modification (GO:0000154)3.87033414
49neuron cell-cell adhesion (GO:0007158)3.83974165
50myelin maintenance (GO:0043217)3.83720458
51regulation of inclusion body assembly (GO:0090083)3.80549137
52motile cilium assembly (GO:0044458)3.76009710
53single fertilization (GO:0007338)3.71839597
54protein localization to Golgi apparatus (GO:0034067)3.71521009
55neuronal ion channel clustering (GO:0045161)3.70733857
56peripheral nervous system axon ensheathment (GO:0032292)3.62584098
57myelination in peripheral nervous system (GO:0022011)3.62584098
58negative regulation of inclusion body assembly (GO:0090084)3.60706371
59regulation of Rab GTPase activity (GO:0032313)3.59927622
60positive regulation of Rab GTPase activity (GO:0032851)3.59927622
61sperm motility (GO:0030317)3.59769466
62locomotory exploration behavior (GO:0035641)3.57207783
63negative regulation of neurotransmitter secretion (GO:0046929)3.56445072
64synaptic vesicle exocytosis (GO:0016079)3.55059691
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52844650
66fusion of sperm to egg plasma membrane (GO:0007342)3.52659070
67transmission of nerve impulse (GO:0019226)3.51873988
68outflow tract septum morphogenesis (GO:0003148)3.51402865
69chromatin silencing (GO:0006342)3.51199447
70response to acidic pH (GO:0010447)3.50855402
71negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.50622169
72germ cell development (GO:0007281)3.49832173
73seminiferous tubule development (GO:0072520)3.47345155
74metanephric nephron epithelium development (GO:0072243)3.46340675
75negative regulation of neurotransmitter transport (GO:0051589)3.45467761
76centriole replication (GO:0007099)3.43741248
77regulation of synaptic vesicle exocytosis (GO:2000300)3.41442721
78RNA destabilization (GO:0050779)3.37889305
79regulation of short-term neuronal synaptic plasticity (GO:0048172)3.36896949
80metanephric epithelium development (GO:0072207)3.36114175
81nucleosome disassembly (GO:0006337)3.35139839
82protein-DNA complex disassembly (GO:0032986)3.35139839
83polyamine biosynthetic process (GO:0006596)3.34698091
84cell-cell junction maintenance (GO:0045217)3.34214777
85postsynaptic membrane organization (GO:0001941)3.32221128
86cilium movement (GO:0003341)3.30643854
87regulation of collateral sprouting (GO:0048670)3.30088449
88multicellular organismal reproductive process (GO:0048609)3.29921460
89presynaptic membrane organization (GO:0097090)3.27874938
90response to methylmercury (GO:0051597)3.27392238
91organic cation transport (GO:0015695)3.26980028
92presynaptic membrane assembly (GO:0097105)3.24953715
93calcium ion-dependent exocytosis (GO:0017156)3.21294271
94cellular process involved in reproduction in multicellular organism (GO:0022412)3.21197644
95adult walking behavior (GO:0007628)3.18134145
96positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.17990538
97establishment of mitochondrion localization (GO:0051654)3.15987251
98glycine transport (GO:0015816)3.14684797
99substantia nigra development (GO:0021762)3.14240748
100centriole assembly (GO:0098534)3.13920420
101negative regulation of axonogenesis (GO:0050771)3.13614060
102fertilization (GO:0009566)3.13172883
103amino acid import (GO:0043090)3.08245045
104glutamate secretion (GO:0014047)3.07960731
105spinal cord motor neuron differentiation (GO:0021522)3.06883975
106pharyngeal system development (GO:0060037)3.05109255
107mating behavior (GO:0007617)2.97580678
108coenzyme catabolic process (GO:0009109)2.96086629
109oligodendrocyte differentiation (GO:0048709)2.95319011
110cerebral cortex neuron differentiation (GO:0021895)2.94845007
111sperm capacitation (GO:0048240)2.93841480
112negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.92834471
113detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.92199436
114detection of temperature stimulus involved in sensory perception (GO:0050961)2.92199436
115protein localization to synapse (GO:0035418)2.91267089
116membrane protein intracellular domain proteolysis (GO:0031293)2.90128181
117acrosome assembly (GO:0001675)2.89753836
118negative regulation of axon extension (GO:0030517)2.88685845
119photoreceptor cell differentiation (GO:0046530)2.88537454
120eye photoreceptor cell differentiation (GO:0001754)2.88537454
121response to redox state (GO:0051775)2.88403766
122dendrite morphogenesis (GO:0048813)2.87496934
123dendritic spine morphogenesis (GO:0060997)2.87357015
124plasma membrane fusion (GO:0045026)2.87274281
125ionotropic glutamate receptor signaling pathway (GO:0035235)2.87120487
126cerebellar granule cell differentiation (GO:0021707)2.85719132
127cellular response to pH (GO:0071467)2.85667292
128peripheral nervous system development (GO:0007422)2.84863442
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84303989
130microtubule nucleation (GO:0007020)2.83992118
131lung epithelium development (GO:0060428)2.83929455
132cellular potassium ion homeostasis (GO:0030007)2.83731041
133neuron recognition (GO:0008038)2.81636046
134layer formation in cerebral cortex (GO:0021819)2.81616823
135gamma-aminobutyric acid transport (GO:0015812)2.81315365
136vocalization behavior (GO:0071625)2.80485757
137detection of temperature stimulus (GO:0016048)2.78364324
138regulation of synaptic vesicle transport (GO:1902803)2.78225571
139mitochondrion transport along microtubule (GO:0047497)2.77978635
140establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77978635
141dendritic spine organization (GO:0097061)2.77295235
142cilium or flagellum-dependent cell motility (GO:0001539)2.77131779
143auditory behavior (GO:0031223)2.77097488
144astrocyte development (GO:0014002)2.74640806
145glycerophospholipid catabolic process (GO:0046475)2.73953026
146neurofilament cytoskeleton organization (GO:0060052)2.73609492
147negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73307338
148nucleus organization (GO:0006997)2.72730898
149regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72451709
150apical protein localization (GO:0045176)2.71890172
151regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71027559
152asymmetric protein localization (GO:0008105)2.70993304
153regulation of voltage-gated calcium channel activity (GO:1901385)2.69970981
154cholesterol biosynthetic process (GO:0006695)2.69854143
155outer ear morphogenesis (GO:0042473)2.69343024
156nonmotile primary cilium assembly (GO:0035058)2.69164588
157glutamate receptor signaling pathway (GO:0007215)2.68306594
158neurotransmitter-gated ion channel clustering (GO:0072578)2.68088424
159negative regulation of protein localization to cell surface (GO:2000009)2.67809351
160growth hormone secretion (GO:0030252)2.66932150
161neuron-neuron synaptic transmission (GO:0007270)2.66738531
162regulation of mesenchymal cell apoptotic process (GO:2001053)2.65882771
163synaptic transmission, glutamatergic (GO:0035249)2.65290882
164membrane hyperpolarization (GO:0060081)2.63105217
165neurotransmitter secretion (GO:0007269)2.60354311
166cell migration in hindbrain (GO:0021535)2.60306515
167sodium ion export (GO:0071436)2.60080107
168cell wall macromolecule catabolic process (GO:0016998)2.58922107
169cell wall macromolecule metabolic process (GO:0044036)2.58922107
170creatine metabolic process (GO:0006600)2.56299368
171axonal fasciculation (GO:0007413)2.56226005
172positive regulation of neurological system process (GO:0031646)2.56208407
173multicellular organism reproduction (GO:0032504)2.55978762
174exploration behavior (GO:0035640)2.54994862
175membrane depolarization during action potential (GO:0086010)2.53949978
176gamma-aminobutyric acid signaling pathway (GO:0007214)2.53438371
177cellular response to epinephrine stimulus (GO:0071872)2.53334374
178potassium ion homeostasis (GO:0055075)2.52097446
179potassium ion import (GO:0010107)2.50679315
180axonemal dynein complex assembly (GO:0070286)2.50617255
181regulation of neuronal synaptic plasticity (GO:0048168)2.50580134
182neurotransmitter transport (GO:0006836)2.50281217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67049278
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.16082706
3GBX2_23144817_ChIP-Seq_PC3_Human3.00678000
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51918272
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45176888
6* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27364555
7DROSHA_22980978_ChIP-Seq_HELA_Human2.26547475
8* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24879577
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24739966
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18367149
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18367149
12* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11392685
13* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10462179
14* CTCF_27219007_Chip-Seq_Bcells_Human2.07154405
15REST_21632747_ChIP-Seq_MESCs_Mouse2.06505307
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.06306004
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02574623
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01734865
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95663118
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95333255
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91156730
22* RNF2_27304074_Chip-Seq_ESCs_Mouse1.88076164
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84699713
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83380191
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81208817
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77996379
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.77410125
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77132847
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.73965527
30TAF15_26573619_Chip-Seq_HEK293_Human1.70048855
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.69655036
32LXR_22292898_ChIP-Seq_THP-1_Human1.66601119
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.65539907
34AR_21572438_ChIP-Seq_LNCaP_Human1.64821721
35BCL6_27268052_Chip-Seq_Bcells_Human1.64580922
36ERA_21632823_ChIP-Seq_H3396_Human1.60268727
37P68_20966046_ChIP-Seq_HELA_Human1.60169275
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.58850671
39CBP_20019798_ChIP-Seq_JUKART_Human1.58238492
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58238492
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56568185
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.56545543
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52643890
44SMC4_20622854_ChIP-Seq_HELA_Human1.52022299
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49606987
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46755872
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45648256
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.44914618
49CTCF_20526341_ChIP-Seq_ESCs_Human1.44253307
50YY1_22570637_ChIP-Seq_MALME-3M_Human1.43956655
51* RAC3_21632823_ChIP-Seq_H3396_Human1.40522859
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38334246
53EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.38283384
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36854248
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36415923
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36011870
57SMAD4_21799915_ChIP-Seq_A2780_Human1.35909589
58E2F1_20622854_ChIP-Seq_HELA_Human1.35392229
59VDR_22108803_ChIP-Seq_LS180_Human1.35303428
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34821468
61PHF8_20622854_ChIP-Seq_HELA_Human1.34722041
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34230537
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33048329
64TAF2_19829295_ChIP-Seq_ESCs_Human1.32089609
65ER_23166858_ChIP-Seq_MCF-7_Human1.31912873
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.31696003
67BCOR_27268052_Chip-Seq_Bcells_Human1.31567291
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31508030
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31497338
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30235788
71NANOG_20526341_ChIP-Seq_ESCs_Human1.28855285
72FUS_26573619_Chip-Seq_HEK293_Human1.28153627
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23915930
74TP63_22573176_ChIP-Seq_HFKS_Human1.21909460
75* TP53_20018659_ChIP-ChIP_R1E_Mouse1.21202137
76RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20949152
77MYC_19829295_ChIP-Seq_ESCs_Human1.20478128
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.19634058
79STAT3_23295773_ChIP-Seq_U87_Human1.19257864
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.18496278
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18487220
82* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17852737
83OCT4_20526341_ChIP-Seq_ESCs_Human1.17742609
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17512617
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17322164
86P300_19829295_ChIP-Seq_ESCs_Human1.14009252
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13971030
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12875721
89ZNF274_21170338_ChIP-Seq_K562_Hela1.11919325
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10617428
91AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10579647
92SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10071491
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09859031
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09470059
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.09456836
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.09054273
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.08908144
98TCF4_23295773_ChIP-Seq_U87_Human1.08367969
99MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07585958
100* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07566220
101OCT4_19829295_ChIP-Seq_ESCs_Human1.07560754
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06934698
103P300_27268052_Chip-Seq_Bcells_Human1.06754419
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05383475
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05276188
106RNF2_27304074_Chip-Seq_NSC_Mouse1.05242966
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.03583309
108P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03514052
109* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02671994
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02618854
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02190306
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.02163522
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01696701
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.01512186
115AHR_22903824_ChIP-Seq_MCF-7_Human1.01480183
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.01352493
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00950369
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00950369
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00745182
120EP300_21415370_ChIP-Seq_HL-1_Mouse1.00702569
121* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00417095
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00080599
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99399404
124SA1_27219007_Chip-Seq_Bcells_Human0.98974204
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98826457
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98780399
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98374139
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98372568
129TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96666655
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.95243808
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.95177246
132FOXP1_21924763_ChIP-Seq_HESCs_Human0.94674830
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94390593
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94181711
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93988374
136KDM2B_26808549_Chip-Seq_REH_Human0.93669918
137* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92639399
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.91652405
139AR_19668381_ChIP-Seq_PC3_Human0.90541424
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90490890
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.90480203
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89677908
143* RING1B_27294783_Chip-Seq_NPCs_Mouse0.89490380
144MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89272536
145AR_25329375_ChIP-Seq_VCAP_Human0.89190763
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88638224
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.88571282
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.88209348
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88143044
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.87776799
151LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87752410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.16267952
2MP0000920_abnormal_myelination4.15094029
3MP0004859_abnormal_synaptic_plasticity3.71568301
4MP0003880_abnormal_central_pattern3.65539208
5MP0004270_analgesia3.44579705
6MP0005670_abnormal_white_adipose3.24169052
7MP0005377_hearing/vestibular/ear_phenot3.22017321
8MP0003878_abnormal_ear_physiology3.22017321
9MP0002272_abnormal_nervous_system3.06811801
10MP0001968_abnormal_touch/_nociception2.86527132
11MP0009046_muscle_twitch2.81580517
12MP0003635_abnormal_synaptic_transmissio2.77855473
13MP0002734_abnormal_mechanical_nocicepti2.69293652
14MP0003329_amyloid_beta_deposits2.67136273
15MP0002064_seizures2.62840311
16MP0001486_abnormal_startle_reflex2.51320937
17MP0009745_abnormal_behavioral_response2.34933357
18MP0003634_abnormal_glial_cell2.26447262
19MP0005423_abnormal_somatic_nervous2.17946993
20MP0003283_abnormal_digestive_organ2.17314389
21MP0004885_abnormal_endolymph2.16849365
22MP0002234_abnormal_pharynx_morphology2.14170762
23MP0003690_abnormal_glial_cell2.13190549
24MP0000778_abnormal_nervous_system2.07248306
25MP0005623_abnormal_meninges_morphology2.06289843
26MP0002063_abnormal_learning/memory/cond2.05331742
27MP0004742_abnormal_vestibular_system2.05082427
28MP0002733_abnormal_thermal_nociception2.01800766
29MP0002067_abnormal_sensory_capabilities2.00813275
30MP0005379_endocrine/exocrine_gland_phen2.00581718
31MP0000678_abnormal_parathyroid_gland1.99646698
32MP0008569_lethality_at_weaning1.96565049
33MP0002572_abnormal_emotion/affect_behav1.92492123
34MP0002736_abnormal_nociception_after1.91253762
35MP0005248_abnormal_Harderian_gland1.90995717
36MP0002735_abnormal_chemical_nociception1.89897940
37MP0004142_abnormal_muscle_tone1.82607944
38MP0001970_abnormal_pain_threshold1.81663241
39MP0005171_absent_coat_pigmentation1.78720107
40MP0002229_neurodegeneration1.75838361
41MP0003122_maternal_imprinting1.74851377
42MP0001440_abnormal_grooming_behavior1.69660525
43MP0002249_abnormal_larynx_morphology1.68054669
44MP0003632_abnormal_nervous_system1.66632977
45MP0000955_abnormal_spinal_cord1.66140286
46MP0005551_abnormal_eye_electrophysiolog1.64449590
47MP0001905_abnormal_dopamine_level1.63168822
48MP0003698_abnormal_male_reproductive1.62970111
49MP0003136_yellow_coat_color1.59769085
50MP0001529_abnormal_vocalization1.58984347
51MP0002882_abnormal_neuron_morphology1.57418470
52MP0003631_nervous_system_phenotype1.51905955
53MP0003011_delayed_dark_adaptation1.50373868
54MP0001984_abnormal_olfaction1.47757504
55MP0002066_abnormal_motor_capabilities/c1.43629614
56MP0003633_abnormal_nervous_system1.42652554
57MP0000049_abnormal_middle_ear1.41837000
58MP0001485_abnormal_pinna_reflex1.39340966
59MP0008260_abnormal_autophagy1.37936789
60MP0002184_abnormal_innervation1.37321357
61MP0000604_amyloidosis1.34421574
62MP0004145_abnormal_muscle_electrophysio1.31663869
63MP0002210_abnormal_sex_determination1.30160971
64MP0004811_abnormal_neuron_physiology1.29348987
65MP0004858_abnormal_nervous_system1.29134886
66MP0002557_abnormal_social/conspecific_i1.28777996
67MP0003787_abnormal_imprinting1.24813286
68MP0002822_catalepsy1.24788650
69MP0001501_abnormal_sleep_pattern1.24580480
70MP0002127_abnormal_cardiovascular_syste1.22851851
71MP0000747_muscle_weakness1.21853874
72MP0002752_abnormal_somatic_nervous1.21027622
73MP0005386_behavior/neurological_phenoty1.17513815
74MP0004924_abnormal_behavior1.17513815
75MP0000751_myopathy1.15798003
76MP0000681_abnormal_thyroid_gland1.13663640
77MP0001963_abnormal_hearing_physiology1.12989840
78MP0005394_taste/olfaction_phenotype1.11268628
79MP0005499_abnormal_olfactory_system1.11268628
80MP0001502_abnormal_circadian_rhythm1.10223850
81MP0005409_darkened_coat_color1.08335153
82MP0000462_abnormal_digestive_system1.07119341
83MP0003950_abnormal_plasma_membrane1.06606410
84MP0000516_abnormal_urinary_system1.05745957
85MP0005367_renal/urinary_system_phenotyp1.05745957
86MP0001145_abnormal_male_reproductive1.05307054
87MP0002102_abnormal_ear_morphology1.03887258
88MP0003718_maternal_effect1.03355698
89MP0006276_abnormal_autonomic_nervous1.03267468
90MP0003646_muscle_fatigue1.02303411
91MP0002152_abnormal_brain_morphology1.01722568
92MP0000653_abnormal_sex_gland1.00274538
93MP0002090_abnormal_vision1.00004392
94MP0004043_abnormal_pH_regulation0.99788267
95MP0001929_abnormal_gametogenesis0.99587009
96MP0001299_abnormal_eye_distance/0.96583630
97MP0002282_abnormal_trachea_morphology0.94431188
98MP0003045_fibrosis0.93788332
99MP0004134_abnormal_chest_morphology0.91802029
100MP0006072_abnormal_retinal_apoptosis0.90575933
101MP0001348_abnormal_lacrimal_gland0.90362405
102MP0004272_abnormal_basement_membrane0.88759443
103MP0009780_abnormal_chondrocyte_physiolo0.88072664
104MP0003121_genomic_imprinting0.87230656
105MP0008877_abnormal_DNA_methylation0.84877059
106MP0005253_abnormal_eye_physiology0.84781687
107MP0000749_muscle_degeneration0.83675511
108MP0002161_abnormal_fertility/fecundity0.80707191
109MP0005195_abnormal_posterior_eye0.79936911
110MP0001270_distended_abdomen0.79684045
111MP0003879_abnormal_hair_cell0.79172690
112MP0008995_early_reproductive_senescence0.78825192
113MP0001177_atelectasis0.77893897
114MP0000631_abnormal_neuroendocrine_gland0.77605209
115MP0004085_abnormal_heartbeat0.76077344
116MP0008789_abnormal_olfactory_epithelium0.75973307
117MP0000013_abnormal_adipose_tissue0.75047574
118MP0001661_extended_life_span0.74560202
119MP0001188_hyperpigmentation0.74433470
120MP0002132_abnormal_respiratory_system0.73944856
121MP0004233_abnormal_muscle_weight0.72844706
122MP0005645_abnormal_hypothalamus_physiol0.72612511
123MP0005646_abnormal_pituitary_gland0.71458821
124MP0000003_abnormal_adipose_tissue0.71419375
125MP0002653_abnormal_ependyma_morphology0.70634735
126MP0005391_vision/eye_phenotype0.69496323
127MP0002751_abnormal_autonomic_nervous0.67452915
128MP0004147_increased_porphyrin_level0.67296754
129MP0000026_abnormal_inner_ear0.62562647
130MP0001346_abnormal_lacrimal_gland0.62163073
131MP0002069_abnormal_eating/drinking_beha0.61965432
132MP0000534_abnormal_ureter_morphology0.61842568
133MP0004036_abnormal_muscle_relaxation0.61047735
134MP0002108_abnormal_muscle_morphology0.60668066
135MP0001943_abnormal_respiration0.59877206
136MP0003861_abnormal_nervous_system0.58684261
137MP0003137_abnormal_impulse_conducting0.56826875

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)7.83929549
2Segmental peripheral demyelination/remyelination (HP:0003481)7.13801446
3Termporal pattern (HP:0011008)6.97366850
4Insidious onset (HP:0003587)6.97366850
5Action tremor (HP:0002345)6.34272680
6Peripheral hypomyelination (HP:0007182)5.89719438
7Severe visual impairment (HP:0001141)5.40370377
8Onion bulb formation (HP:0003383)5.29368837
9Impaired proprioception (HP:0010831)5.05403819
10Neurofibrillary tangles (HP:0002185)4.40782166
11Double outlet right ventricle (HP:0001719)4.40461819
12Congenital malformation of the right heart (HP:0011723)4.40461819
13Myokymia (HP:0002411)4.03792526
14Tubulointerstitial nephritis (HP:0001970)3.95055933
15Supranuclear gaze palsy (HP:0000605)3.90103440
16Steppage gait (HP:0003376)3.86045751
17Absent/shortened dynein arms (HP:0200106)3.84548825
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.84548825
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.83857714
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.83857714
21Decreased motor nerve conduction velocity (HP:0003431)3.71435821
22Abnormality of the aortic arch (HP:0012303)3.68353349
23Hammertoe (HP:0001765)3.67042228
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.60372055
25Bony spicule pigmentary retinopathy (HP:0007737)3.56210706
26Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.55003022
27Resting tremor (HP:0002322)3.48735854
28Abnormality of the corticospinal tract (HP:0002492)3.46852399
29Sensory axonal neuropathy (HP:0003390)3.45012799
30Foot dorsiflexor weakness (HP:0009027)3.43397779
31Postural tremor (HP:0002174)3.41382478
32Chronic hepatic failure (HP:0100626)3.41233913
33Attenuation of retinal blood vessels (HP:0007843)3.39300317
34Cerebral inclusion bodies (HP:0100314)3.36729243
35Hyperthyroidism (HP:0000836)3.33900278
36Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.31035758
37Increased CSF protein (HP:0002922)3.25930247
38Upper limb muscle weakness (HP:0003484)3.23761765
39Abnormal pupillary function (HP:0007686)3.18153649
40Abnormality of the foot musculature (HP:0001436)3.13550123
41Ankle clonus (HP:0011448)3.13213375
42Asymmetric septal hypertrophy (HP:0001670)3.12849965
43Focal motor seizures (HP:0011153)3.05929094
44Peripheral demyelination (HP:0011096)3.05527265
45Male infertility (HP:0003251)3.04866967
46Abnormal rod and cone electroretinograms (HP:0008323)3.01765208
47Renal dysplasia (HP:0000110)3.00171953
48Spastic gait (HP:0002064)3.00111328
49Nephronophthisis (HP:0000090)2.98744059
50Impulsivity (HP:0100710)2.96349284
51Abnormality of macular pigmentation (HP:0008002)2.92820518
52Abnormal auditory evoked potentials (HP:0006958)2.89809936
53Renal Fanconi syndrome (HP:0001994)2.87375497
54Intention tremor (HP:0002080)2.86965984
55Truncus arteriosus (HP:0001660)2.86357500
56Dysmetria (HP:0001310)2.78680687
57Retinal dysplasia (HP:0007973)2.72780047
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71960789
59Cerebral hypomyelination (HP:0006808)2.70368481
60Distal sensory impairment (HP:0002936)2.69086344
61Abnormality of the parathyroid morphology (HP:0011766)2.68924417
62Failure to thrive in infancy (HP:0001531)2.67834629
63Abnormal respiratory motile cilium physiology (HP:0012261)2.67292625
64Hyperkalemia (HP:0002153)2.65215653
65Aplasia/Hypoplasia of the earlobes (HP:0009906)2.64609332
66Focal seizures (HP:0007359)2.64373754
67Abnormality of the vocal cords (HP:0008777)2.64013757
68Transposition of the great arteries (HP:0001669)2.62790860
69Abnormal connection of the cardiac segments (HP:0011545)2.62790860
70Abnormal ventriculo-arterial connection (HP:0011563)2.62790860
71Atonic seizures (HP:0010819)2.62204902
72Amblyopia (HP:0000646)2.59042748
73Potter facies (HP:0002009)2.58804318
74Facial shape deformation (HP:0011334)2.58804318
75Unilateral renal agenesis (HP:0000122)2.57530309
76Generalized aminoaciduria (HP:0002909)2.56905953
77Menstrual irregularities (HP:0000858)2.54395242
78Hypomagnesemia (HP:0002917)2.52010064
79Abnormal urine output (HP:0012590)2.51568932
80Hypoplastic ischia (HP:0003175)2.49418098
81Polyphagia (HP:0002591)2.48654763
82Hypoplasia of the thymus (HP:0000778)2.46239081
83Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.45963938
84Bell-shaped thorax (HP:0001591)2.44292098
85Retinal atrophy (HP:0001105)2.42657466
86Amelogenesis imperfecta (HP:0000705)2.41951805
87Progressive cerebellar ataxia (HP:0002073)2.40452216
88Abnormal drinking behavior (HP:0030082)2.39613447
89Polydipsia (HP:0001959)2.39613447
90Abnormality of the renal medulla (HP:0100957)2.37752887
91Abnormal respiratory motile cilium morphology (HP:0005938)2.35832972
92Abnormal respiratory epithelium morphology (HP:0012253)2.35832972
93Polyuria (HP:0000103)2.35638453
94Flattened epiphyses (HP:0003071)2.35159318
95Abnormality of the ischium (HP:0003174)2.32568871
96Hypoplastic left heart (HP:0004383)2.31348071
97Epileptic encephalopathy (HP:0200134)2.30420150
98Cone-rod dystrophy (HP:0000548)2.30219699
99Enlarged epiphyses (HP:0010580)2.29370089
100Akinesia (HP:0002304)2.28506784
101Absent epiphyses (HP:0010577)2.26499988
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.26499988
103Cerebellar dysplasia (HP:0007033)2.22939233
104Parakeratosis (HP:0001036)2.21003864
105Abnormal ciliary motility (HP:0012262)2.20432738
106Stage 5 chronic kidney disease (HP:0003774)2.17821638
107Abnormality of urine glucose concentration (HP:0011016)2.17315690
108Glycosuria (HP:0003076)2.17315690
109Sclerocornea (HP:0000647)2.16307719
110Slow saccadic eye movements (HP:0000514)2.15449868
111Abnormality of renal excretion (HP:0011036)2.11023909
112Scanning speech (HP:0002168)2.10980260
113Pheochromocytoma (HP:0002666)2.07700324
114Abnormality of renal resorption (HP:0011038)2.07114159
115Nasal polyposis (HP:0100582)2.06610735
116Lower limb muscle weakness (HP:0007340)2.05165681
117Limb dystonia (HP:0002451)2.04796404
118Abnormality of magnesium homeostasis (HP:0004921)2.04745302
119Hemiparesis (HP:0001269)2.04630545
120Occipital encephalocele (HP:0002085)2.04518739
121Visual hallucinations (HP:0002367)2.04113201
122Gaze-evoked nystagmus (HP:0000640)2.03872360
123Progressive sensorineural hearing impairment (HP:0000408)2.03273173
124Gait imbalance (HP:0002141)2.02661651
125Clonus (HP:0002169)1.99539493
126Renovascular hypertension (HP:0100817)1.98464655
127Slow progression (HP:0003677)1.96341140
128Abnormality of potassium homeostasis (HP:0011042)1.95138855
129True hermaphroditism (HP:0010459)1.94971237
130Tubulointerstitial abnormality (HP:0001969)1.94677011
131Megalencephaly (HP:0001355)1.93985675
132Urinary urgency (HP:0000012)1.93854841
133Alacrima (HP:0000522)1.93364356
134Increased circulating renin level (HP:0000848)1.92997861
135Decreased central vision (HP:0007663)1.92514029
136Pancreatic fibrosis (HP:0100732)1.92086939
137Hypoplastic heart (HP:0001961)1.91946036
138Insulin-resistant diabetes mellitus (HP:0000831)1.91544806
139Tetany (HP:0001281)1.91211155
140Delusions (HP:0000746)1.90703286
141Clumsiness (HP:0002312)1.90462846
142Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90331379
143Dysdiadochokinesis (HP:0002075)1.89511686
144Truncal obesity (HP:0001956)1.88398953
145Rhinitis (HP:0012384)1.87643190
146Turricephaly (HP:0000262)1.85224285
147Gait ataxia (HP:0002066)1.84249369
148Spastic tetraparesis (HP:0001285)1.82134325
149Infertility (HP:0000789)1.81843846
150Leukodystrophy (HP:0002415)1.81779585
151Abnormality of saccadic eye movements (HP:0000570)1.81270927
152Atelectasis (HP:0100750)1.80715675
153Bowel incontinence (HP:0002607)1.80228067
154Type II lissencephaly (HP:0007260)1.78541942
155Dialeptic seizures (HP:0011146)1.78530905
156Neuroendocrine neoplasm (HP:0100634)1.76601005
157Mixed hearing impairment (HP:0000410)1.76542216
158Abnormality of dental color (HP:0011073)1.74782597
159Recurrent corneal erosions (HP:0000495)1.73980708
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73811513
161Hand muscle atrophy (HP:0009130)1.72709827
162Postural instability (HP:0002172)1.72218027
163Neuronal loss in central nervous system (HP:0002529)1.70852505
164Preauricular pit (HP:0004467)1.70636081
165Periauricular skin pits (HP:0100277)1.70636081
166Absence seizures (HP:0002121)1.69960650
167CNS hypomyelination (HP:0003429)1.68746990
168Mutism (HP:0002300)1.68518940
169Poor suck (HP:0002033)1.68267724
170Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67903188
171Hypoplasia of the brainstem (HP:0002365)1.67903188
172Truncal ataxia (HP:0002078)1.67341691
173Aplasia involving bones of the extremities (HP:0009825)1.66947745
174Aplasia involving bones of the upper limbs (HP:0009823)1.66947745
175Aplasia of the phalanges of the hand (HP:0009802)1.66947745
176Poor speech (HP:0002465)1.66610109
177Urinary bladder sphincter dysfunction (HP:0002839)1.66476151
178Abnormality of calcium-phosphate metabolism (HP:0100530)1.65415875
179Morphological abnormality of the pyramidal tract (HP:0002062)1.64409083
180Abnormal eating behavior (HP:0100738)1.63035982
181Difficulty walking (HP:0002355)1.62100890
182Vaginal atresia (HP:0000148)1.61485056
183Genital tract atresia (HP:0001827)1.60848386
184Torticollis (HP:0000473)1.56955526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.29553756
2PLK45.09841626
3MAP4K25.07049302
4OXSR13.21905378
5DDR23.18720474
6WNK43.12936655
7ICK2.89685496
8EPHB12.75908623
9STK162.64341368
10INSRR2.40628127
11TNIK2.37694151
12WNK12.32354795
13BRD42.29026234
14PRKD32.16982421
15PNCK2.07155154
16TYRO32.00367835
17PRPF4B1.97011501
18MARK11.96152936
19DYRK1B1.95488994
20NTRK11.92148256
21PAK61.90745169
22UHMK11.88579062
23PKN11.83470952
24MAP3K91.75052878
25CDK191.74735223
26NTRK31.74593394
27PDK31.70966751
28PDK41.70966751
29IRAK21.68171901
30EPHA41.66221493
31SIK21.62511169
32MAP3K41.54308173
33MINK11.51979838
34BMPR1B1.49737201
35MAPKAPK51.48249346
36LIMK11.42527478
37BCR1.39537829
38KSR21.36736299
39STK38L1.33432492
40SGK2231.33069448
41SGK4941.33069448
42TESK11.28658365
43PHKG11.27724960
44PHKG21.27724960
45TLK11.21646329
46EEF2K1.20351581
47NTRK21.18892345
48PDK21.16629958
49ROCK21.16381795
50NEK61.16210824
51CDK51.16184675
52MAP3K111.11194751
53FGFR21.10135586
54PTK2B1.09491412
55MAPK131.07899321
56MARK21.07852428
57TESK21.06131066
58CASK1.04750236
59FES1.02200834
60MET1.01490235
61CDK141.00807674
62CAMK2B0.99525690
63IRAK10.97000410
64MAP2K70.95389597
65PAK30.92566488
66BCKDK0.90768481
67CAMK2D0.90041552
68CDK150.89715948
69CSNK1G20.89093182
70CSNK1G30.88444524
71ARAF0.86950309
72MAP3K20.86203129
73CDK180.85874177
74DYRK30.84955425
75CAMK1G0.84681604
76FGR0.84579276
77RPS6KA20.84286035
78CSNK1A1L0.84188407
79RET0.81191050
80LMTK20.79883262
81PDPK10.79446528
82CAMK2A0.78575851
83CDK11A0.78252830
84FRK0.74356315
85STK380.73168582
86GRK50.71305215
87PRKCG0.70696317
88CDK70.69346800
89CAMK2G0.69342450
90PDK10.69035757
91AKT30.67306322
92PINK10.67050033
93DAPK20.66492005
94PLK20.61323875
95WNK30.58282533
96CAMKK10.58204310
97STK110.57786105
98FYN0.57453690
99MAP2K40.57367062
100PRKCQ0.56948811
101CAMK10.55180823
102PRKCE0.54008393
103CSNK1G10.52040849
104DYRK20.51610232
105GRK70.50715199
106PRKD20.50490573
107ROCK10.48225292
108PRKCH0.48124605
109PBK0.46179561
110DYRK1A0.46161453
111RPS6KA10.43134646
112MAPK150.42700505
113PRKAA20.42472426
114PRKAA10.40239710
115PRKD10.39473136
116PRKG20.39190791
117RIPK40.38687877
118MUSK0.38578446
119PRKG10.38553831
120VRK10.37980026
121CAMK40.37386339
122BRAF0.36705842
123PRKCZ0.36206925
124CLK10.35312155
125GSK3B0.34975721
126TAF10.34373366
127MAPK100.34364969
128BMX0.33971601
129PRKACB0.33000036
130LATS20.32862144
131PRKACA0.31976526
132CDK20.31843104
133SGK10.31116152
134CDK80.30611268
135MAP2K20.30281995
136MAPK80.30036861
137CSNK1A10.26223991
138MAPK10.24669599

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.34206433
2Synaptic vesicle cycle_Homo sapiens_hsa047212.64472999
3Steroid biosynthesis_Homo sapiens_hsa001002.43704338
4Nicotine addiction_Homo sapiens_hsa050332.26255975
5Glutamatergic synapse_Homo sapiens_hsa047242.12316854
6GABAergic synapse_Homo sapiens_hsa047272.09528768
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08541799
8Fatty acid elongation_Homo sapiens_hsa000622.06329308
9Axon guidance_Homo sapiens_hsa043602.01535420
10Ether lipid metabolism_Homo sapiens_hsa005651.99226224
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91956135
12Circadian entrainment_Homo sapiens_hsa047131.83051185
13Morphine addiction_Homo sapiens_hsa050321.78002829
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77770298
15Long-term potentiation_Homo sapiens_hsa047201.62835700
16Salivary secretion_Homo sapiens_hsa049701.60449889
17Olfactory transduction_Homo sapiens_hsa047401.60292221
18Collecting duct acid secretion_Homo sapiens_hsa049661.58751873
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57407530
20Dopaminergic synapse_Homo sapiens_hsa047281.55956510
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53113357
22Serotonergic synapse_Homo sapiens_hsa047261.52424225
23Arginine and proline metabolism_Homo sapiens_hsa003301.51038868
24Long-term depression_Homo sapiens_hsa047301.50075257
25Amphetamine addiction_Homo sapiens_hsa050311.49855268
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45300135
27Vitamin B6 metabolism_Homo sapiens_hsa007501.42889508
28Cholinergic synapse_Homo sapiens_hsa047251.42185202
29Gastric acid secretion_Homo sapiens_hsa049711.42078316
30Dorso-ventral axis formation_Homo sapiens_hsa043201.41170062
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38180276
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37402460
33Renin secretion_Homo sapiens_hsa049241.34212509
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33591681
35Fatty acid degradation_Homo sapiens_hsa000711.30152305
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28916737
37Cardiac muscle contraction_Homo sapiens_hsa042601.26795005
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.24014519
39Insulin secretion_Homo sapiens_hsa049111.21845012
40Fatty acid biosynthesis_Homo sapiens_hsa000611.21279578
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19969293
42Taste transduction_Homo sapiens_hsa047421.18542242
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17833409
44Cocaine addiction_Homo sapiens_hsa050301.16219623
45Gap junction_Homo sapiens_hsa045401.06849225
46Basal cell carcinoma_Homo sapiens_hsa052171.05620617
47Huntingtons disease_Homo sapiens_hsa050161.04088657
48Oxytocin signaling pathway_Homo sapiens_hsa049211.03153372
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02221724
50Vibrio cholerae infection_Homo sapiens_hsa051101.01567417
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.00254376
52Nitrogen metabolism_Homo sapiens_hsa009100.98426793
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.97529062
54Peroxisome_Homo sapiens_hsa041460.97430091
55Calcium signaling pathway_Homo sapiens_hsa040200.97049638
56Sphingolipid metabolism_Homo sapiens_hsa006000.96458983
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96037006
58Oxidative phosphorylation_Homo sapiens_hsa001900.95683574
59Phenylalanine metabolism_Homo sapiens_hsa003600.94827692
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.93224196
61PPAR signaling pathway_Homo sapiens_hsa033200.93222782
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92395776
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92258951
64Phototransduction_Homo sapiens_hsa047440.90553799
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88042499
66ErbB signaling pathway_Homo sapiens_hsa040120.87863299
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87773359
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87250353
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86421548
70Butanoate metabolism_Homo sapiens_hsa006500.86351021
71Endocytosis_Homo sapiens_hsa041440.86069584
72cAMP signaling pathway_Homo sapiens_hsa040240.85349415
73Alzheimers disease_Homo sapiens_hsa050100.84949675
74Renal cell carcinoma_Homo sapiens_hsa052110.84069491
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83232262
76Linoleic acid metabolism_Homo sapiens_hsa005910.81717148
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80933693
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.79427832
79Circadian rhythm_Homo sapiens_hsa047100.79130498
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.78974975
81Pancreatic secretion_Homo sapiens_hsa049720.78203394
82GnRH signaling pathway_Homo sapiens_hsa049120.78127680
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78023363
84Estrogen signaling pathway_Homo sapiens_hsa049150.77298710
85Tight junction_Homo sapiens_hsa045300.77219488
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.77109118
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76711051
88Protein digestion and absorption_Homo sapiens_hsa049740.74773752
89Hedgehog signaling pathway_Homo sapiens_hsa043400.73873592
90Mineral absorption_Homo sapiens_hsa049780.73764054
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73754567
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73667015
93Ras signaling pathway_Homo sapiens_hsa040140.71478689
94Sulfur relay system_Homo sapiens_hsa041220.70741752
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70453941
96Pyruvate metabolism_Homo sapiens_hsa006200.67690661
97Type I diabetes mellitus_Homo sapiens_hsa049400.66615087
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65815887
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65063266
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64149769
101Choline metabolism in cancer_Homo sapiens_hsa052310.62995914
102Thyroid hormone synthesis_Homo sapiens_hsa049180.62708042
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62613285
104Sulfur metabolism_Homo sapiens_hsa009200.60964924
105Parkinsons disease_Homo sapiens_hsa050120.60475113
106Glucagon signaling pathway_Homo sapiens_hsa049220.57948378
107Biosynthesis of amino acids_Homo sapiens_hsa012300.57894812
108Oocyte meiosis_Homo sapiens_hsa041140.56322205
109Glioma_Homo sapiens_hsa052140.55802594
110Melanogenesis_Homo sapiens_hsa049160.54376694
111Type II diabetes mellitus_Homo sapiens_hsa049300.54105904
112Propanoate metabolism_Homo sapiens_hsa006400.53977643
113Hippo signaling pathway_Homo sapiens_hsa043900.53481004
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53269417
115Fatty acid metabolism_Homo sapiens_hsa012120.53076685
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53040975
117Dilated cardiomyopathy_Homo sapiens_hsa054140.51970758
118ABC transporters_Homo sapiens_hsa020100.49302033
119MAPK signaling pathway_Homo sapiens_hsa040100.49070345
120Ovarian steroidogenesis_Homo sapiens_hsa049130.46488646
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46354283
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46217001
123Tyrosine metabolism_Homo sapiens_hsa003500.45752645
124Alcoholism_Homo sapiens_hsa050340.44850060
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44842517
126Inositol phosphate metabolism_Homo sapiens_hsa005620.44075347
127ECM-receptor interaction_Homo sapiens_hsa045120.43533437
128RNA transport_Homo sapiens_hsa030130.43414834
129VEGF signaling pathway_Homo sapiens_hsa043700.42346077
130Metabolic pathways_Homo sapiens_hsa011000.42227118
131Prion diseases_Homo sapiens_hsa050200.41023310
132Bile secretion_Homo sapiens_hsa049760.40907263
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40300453
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39742727
135AMPK signaling pathway_Homo sapiens_hsa041520.39101528
136Selenocompound metabolism_Homo sapiens_hsa004500.37467382
137Wnt signaling pathway_Homo sapiens_hsa043100.35158302

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