DUSP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.68020602
2embryonic process involved in female pregnancy (GO:0060136)4.99199840
3proline metabolic process (GO:0006560)4.77611235
4regulation of integrin activation (GO:0033623)4.64376964
5sulfur amino acid catabolic process (GO:0000098)4.58372653
6negative regulation of fatty acid biosynthetic process (GO:0045717)4.44955390
7L-phenylalanine metabolic process (GO:0006558)4.25906027
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.25906027
9positive regulation of protein homooligomerization (GO:0032464)4.24239924
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.17420005
11L-phenylalanine catabolic process (GO:0006559)4.17420005
12histone H3-K36 demethylation (GO:0070544)4.03657197
13pre-miRNA processing (GO:0031054)3.90765976
14very-low-density lipoprotein particle assembly (GO:0034379)3.86673811
15labyrinthine layer development (GO:0060711)3.76337241
16regulation of cholesterol homeostasis (GO:2000188)3.74370314
17embryonic placenta development (GO:0001892)3.73360847
18response to follicle-stimulating hormone (GO:0032354)3.70806768
19phosphate ion homeostasis (GO:0055062)3.69860550
20trivalent inorganic anion homeostasis (GO:0072506)3.69860550
21intestinal cholesterol absorption (GO:0030299)3.68568797
22layer formation in cerebral cortex (GO:0021819)3.66657000
23cell-cell junction maintenance (GO:0045217)3.65403415
24glutamine family amino acid biosynthetic process (GO:0009084)3.63385251
25protein maturation by protein folding (GO:0022417)3.60372915
26glucocorticoid biosynthetic process (GO:0006704)3.58036553
27transcription from mitochondrial promoter (GO:0006390)3.54109652
28alkaloid metabolic process (GO:0009820)3.53328224
29body morphogenesis (GO:0010171)3.51050115
30aromatic amino acid family catabolic process (GO:0009074)3.48462669
31regulation of protein homooligomerization (GO:0032462)3.47120423
32establishment of apical/basal cell polarity (GO:0035089)3.44319532
33oxidative demethylation (GO:0070989)3.39444460
34regulation of podosome assembly (GO:0071801)3.37985825
35acylglycerol homeostasis (GO:0055090)3.36520320
36triglyceride homeostasis (GO:0070328)3.36520320
37regulation of NFAT protein import into nucleus (GO:0051532)3.35904383
38positive regulation of cellular amide metabolic process (GO:0034250)3.35620351
39cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.33373445
40regulation of RNA export from nucleus (GO:0046831)3.31016987
41cysteine metabolic process (GO:0006534)3.30298423
42glyoxylate metabolic process (GO:0046487)3.29390722
43plasma lipoprotein particle clearance (GO:0034381)3.28631631
44glucocorticoid metabolic process (GO:0008211)3.25307499
45cholesterol efflux (GO:0033344)3.23115341
46hormone catabolic process (GO:0042447)3.21891550
47protein localization to endosome (GO:0036010)3.19917302
48heme transport (GO:0015886)3.17915478
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17593953
50L-ascorbic acid metabolic process (GO:0019852)3.17353609
51embryonic retina morphogenesis in camera-type eye (GO:0060059)3.16124173
52nuclear pore complex assembly (GO:0051292)3.15218691
53low-density lipoprotein particle clearance (GO:0034383)3.12514381
54cellular response to electrical stimulus (GO:0071257)3.10752157
55plasma lipoprotein particle assembly (GO:0034377)3.10492320
56peptidyl-lysine dimethylation (GO:0018027)3.05921344
57protein-lipid complex assembly (GO:0065005)3.05172316
58sarcoplasmic reticulum calcium ion transport (GO:0070296)3.03155993
59peptidyl-glutamic acid carboxylation (GO:0017187)3.02502611
60protein carboxylation (GO:0018214)3.02502611
61urea metabolic process (GO:0019627)3.01738828
62urea cycle (GO:0000050)3.01738828
63regulation of cholesterol biosynthetic process (GO:0045540)2.97610323
64epoxygenase P450 pathway (GO:0019373)2.96487911
65kynurenine metabolic process (GO:0070189)2.95373421
66positive regulation of protein oligomerization (GO:0032461)2.94800123
67sodium ion homeostasis (GO:0055078)2.91233587
68cellular response to ATP (GO:0071318)2.90962786
69negative regulation of fatty acid transport (GO:2000192)2.90245054
70cell junction maintenance (GO:0034331)2.90005779
71bile acid metabolic process (GO:0008206)2.89487273
72tryptophan catabolic process (GO:0006569)2.85804139
73indole-containing compound catabolic process (GO:0042436)2.85804139
74indolalkylamine catabolic process (GO:0046218)2.85804139
75serine family amino acid catabolic process (GO:0009071)2.85113131
76alpha-linolenic acid metabolic process (GO:0036109)2.84372853
77regulation of protein polyubiquitination (GO:1902914)2.81460089
78fatty-acyl-CoA biosynthetic process (GO:0046949)2.80880470
79anterior/posterior axis specification, embryo (GO:0008595)2.80805542
80acetyl-CoA metabolic process (GO:0006084)2.80226732
81cellular modified amino acid catabolic process (GO:0042219)2.80190514
82negative regulation of fatty acid metabolic process (GO:0045922)2.79972248
83exogenous drug catabolic process (GO:0042738)2.79328930
84negative regulation of fibrinolysis (GO:0051918)2.78915155
85homocysteine metabolic process (GO:0050667)2.77712533
86cholesterol homeostasis (GO:0042632)2.77701523
87complement activation, alternative pathway (GO:0006957)2.77279132
88positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.76641969
89negative regulation of histone methylation (GO:0031061)2.76233036
90nitrogen cycle metabolic process (GO:0071941)2.74806469
91cellular anion homeostasis (GO:0030002)2.74517281
92embryonic body morphogenesis (GO:0010172)2.74207609
93high-density lipoprotein particle remodeling (GO:0034375)2.73957183
94sterol homeostasis (GO:0055092)2.72869010
95regulation of nucleobase-containing compound transport (GO:0032239)2.72698321
96establishment or maintenance of monopolar cell polarity (GO:0061339)2.72175807
97establishment of monopolar cell polarity (GO:0061162)2.72175807
98histone lysine demethylation (GO:0070076)2.72025637
99bile acid biosynthetic process (GO:0006699)2.71779428
100tryptophan metabolic process (GO:0006568)2.71431212
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.68878192
102replication fork processing (GO:0031297)2.66215410
103intestinal absorption (GO:0050892)2.66190405
104apical protein localization (GO:0045176)2.63599892
105phospholipid efflux (GO:0033700)2.62773489
106cellular glucuronidation (GO:0052695)2.62536970
107negative regulation of calcium ion transport into cytosol (GO:0010523)2.61898472
108negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61492142
109histone demethylation (GO:0016577)2.60800168
110histone H3-K9 demethylation (GO:0033169)2.59894025
111face development (GO:0060324)2.59611868
112negative regulation of protein activation cascade (GO:2000258)2.59555114
113negative regulation of JAK-STAT cascade (GO:0046426)2.59506170
114regulation of fibrinolysis (GO:0051917)2.58041079
115regulation of protein activation cascade (GO:2000257)2.57652614
116adhesion of symbiont to host cell (GO:0044650)2.56953803
117virion attachment to host cell (GO:0019062)2.56953803
118positive regulation of catenin import into nucleus (GO:0035413)2.56583738
119hypotonic response (GO:0006971)2.56084144
120centrosome localization (GO:0051642)2.52971005
121positive regulation by host of viral transcription (GO:0043923)2.52367482
122positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.51912837
123biotin metabolic process (GO:0006768)2.50929422
124negative regulation of sterol transport (GO:0032372)2.50647631
125negative regulation of cholesterol transport (GO:0032375)2.50647631
126apoptotic process involved in morphogenesis (GO:0060561)2.50112264
127fibrinolysis (GO:0042730)2.48865910
128regulation of cholesterol esterification (GO:0010872)2.48403420
129reverse cholesterol transport (GO:0043691)2.48131167
130regulation of membrane protein ectodomain proteolysis (GO:0051043)2.47501812
131positive regulation of hormone metabolic process (GO:0032352)2.47392134
132drug catabolic process (GO:0042737)2.47021257
133regulation of posttranscriptional gene silencing (GO:0060147)2.46175138
134regulation of gene silencing by miRNA (GO:0060964)2.46175138
135regulation of gene silencing by RNA (GO:0060966)2.46175138
136regulation of cellular amide metabolic process (GO:0034248)2.46174845
137cytolysis (GO:0019835)2.45703702
138positive regulation of hormone biosynthetic process (GO:0046886)2.45500873
139regulation of cholesterol metabolic process (GO:0090181)2.45479939
140regulation of bile acid biosynthetic process (GO:0070857)2.45299326
141response to nitrosative stress (GO:0051409)2.45211746
142lipoprotein metabolic process (GO:0042157)2.45206903
143poly(A)+ mRNA export from nucleus (GO:0016973)2.44719696
144regulation of triglyceride catabolic process (GO:0010896)2.44118513
145ear development (GO:0043583)2.42862835
146cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.42394874
147phospholipid homeostasis (GO:0055091)2.41857908
148asymmetric protein localization (GO:0008105)2.41546955
149neuronal action potential propagation (GO:0019227)2.41539932
150aromatic amino acid family metabolic process (GO:0009072)2.41074063
151cellular response to antibiotic (GO:0071236)2.40881188
152regulation of complement activation (GO:0030449)2.39271452
153insulin-like growth factor receptor signaling pathway (GO:0048009)2.39237724
154adhesion of symbiont to host (GO:0044406)2.38142715
155diacylglycerol metabolic process (GO:0046339)2.37766900
156lipid homeostasis (GO:0055088)2.37746154
157positive regulation of lipoprotein lipase activity (GO:0051006)2.37702024
158positive regulation of triglyceride lipase activity (GO:0061365)2.37702024
159uronic acid metabolic process (GO:0006063)2.37335454
160glucuronate metabolic process (GO:0019585)2.37335454
161response to lipoprotein particle (GO:0055094)2.37095892
162protein-lipid complex remodeling (GO:0034368)2.36198756
163macromolecular complex remodeling (GO:0034367)2.36198756
164plasma lipoprotein particle remodeling (GO:0034369)2.36198756
165macroautophagy (GO:0016236)2.33818173
166androgen biosynthetic process (GO:0006702)2.33571971
167surfactant homeostasis (GO:0043129)2.32809077
168nuclear pore organization (GO:0006999)2.32763058
169ectodermal placode formation (GO:0060788)2.32332748
170plasma lipoprotein particle organization (GO:0071827)2.31868356
171mitochondrion transport along microtubule (GO:0047497)2.31854917
172establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.31854917
173regulation of steroid hormone biosynthetic process (GO:0090030)2.31810809
174regulation of glycogen (starch) synthase activity (GO:2000465)2.29239817
175regulation of histone H3-K27 methylation (GO:0061085)2.28776265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.65615209
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.38612113
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.95030205
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.76191458
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.74843762
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.73093076
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.00501268
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.82879638
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69768682
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.63429670
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.63429670
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.63429670
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.61385074
14* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.52430222
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45954014
16MYC_22102868_ChIP-Seq_BL_Human2.44864794
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.44602323
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43943461
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22390978
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.21211663
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18758760
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.17882422
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.14381694
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.06585846
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02202206
26* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99647166
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94552505
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89806846
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86094259
30TCF7_22412390_ChIP-Seq_EML_Mouse1.82807958
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.79694619
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.79458695
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.77077130
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73734452
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70588877
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69614678
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68448605
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.67962536
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.67714345
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66654871
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57391281
42AR_21909140_ChIP-Seq_LNCAP_Human1.54270125
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.53717516
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53496581
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52130509
46RACK7_27058665_Chip-Seq_MCF-7_Human1.51676256
47CHD1_26751641_Chip-Seq_LNCaP_Human1.51409169
48POU5F1_16518401_ChIP-PET_MESCs_Mouse1.47878724
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46690568
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.43968507
51* FOXO3_23340844_ChIP-Seq_DLD1_Human1.43417557
52ZNF263_19887448_ChIP-Seq_K562_Human1.42221344
53* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41826724
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40585457
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38552274
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37708439
57AHR_22903824_ChIP-Seq_MCF-7_Human1.37569044
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35109226
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33808754
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33631162
61* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33236455
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.31608275
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31258370
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.31253912
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31206087
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30276611
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28593885
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28239042
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.25697846
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25637441
71LXR_22292898_ChIP-Seq_THP-1_Human1.25099716
72* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24950446
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24516655
74* CREB1_26743006_Chip-Seq_LNCaP_Human1.23450341
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22382069
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18470679
77* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17848876
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17606882
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.17213591
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.16269094
81* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15971692
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15849150
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15709207
84VDR_21846776_ChIP-Seq_THP-1_Human1.15113454
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14763983
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14117836
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13100106
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12698259
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12026566
90CLOCK_20551151_ChIP-Seq_293T_Human1.10676300
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09796741
92GATA6_25053715_ChIP-Seq_YYC3_Human1.09274798
93RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08814427
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08805642
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07465470
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07061003
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06935498
98NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06767257
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.06546646
100EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06296635
101* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05815717
102* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04885395
103* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04730272
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03319605
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.01863305
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.01540022
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01511493
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01152321
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00870875
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00730206
111KDM2B_26808549_Chip-Seq_DND41_Human0.99557868
112SMC4_20622854_ChIP-Seq_HELA_Human0.98917115
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98769980
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97943382
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.97666293
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97132485
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96352253
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95687123
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95555574
120GATA4_25053715_ChIP-Seq_YYC3_Human0.95258672
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94728084
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93366159
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92904989
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.92261360
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92080836
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92054040
127* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91369407
128ATF3_27146783_Chip-Seq_COLON_Human0.90069310
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.89664094
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88554789
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88550797
132* ARNT_22903824_ChIP-Seq_MCF-7_Human0.88342442
133IRF8_27001747_Chip-Seq_BMDM_Mouse0.88177011
134* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87822855
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.87731672
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87547637
137KDM2B_26808549_Chip-Seq_K562_Human0.86730768
138* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86720601
139SOX2_20726797_ChIP-Seq_SW620_Human0.86266767
140* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85381597
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84899295
142IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84352485
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83948677
144NANOG_18692474_ChIP-Seq_MEFs_Mouse0.83633045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.55427261
2MP0002139_abnormal_hepatobiliary_system3.97943054
3MP0005085_abnormal_gallbladder_physiolo3.89800665
4MP0003123_paternal_imprinting3.85892386
5MP0005360_urolithiasis3.54733589
6MP0005365_abnormal_bile_salt3.51800737
7MP0003121_genomic_imprinting3.36088691
8MP0009278_abnormal_bone_marrow2.79224017
9MP0003868_abnormal_feces_composition2.74183612
10MP0003453_abnormal_keratinocyte_physiol2.59094128
11MP0002254_reproductive_system_inflammat2.46373324
12MP0005171_absent_coat_pigmentation2.43949738
13MP0008057_abnormal_DNA_replication2.35276872
14MP0008875_abnormal_xenobiotic_pharmacok2.29109191
15MP0009840_abnormal_foam_cell2.18882491
16MP0003806_abnormal_nucleotide_metabolis2.17514500
17MP0003941_abnormal_skin_development2.12194918
18MP0002796_impaired_skin_barrier2.12021307
19MP0003252_abnormal_bile_duct2.02010399
20MP0009672_abnormal_birth_weight2.01091244
21MP0010030_abnormal_orbit_morphology1.94515534
22MP0004782_abnormal_surfactant_physiolog1.92754946
23MP0000566_synostosis1.87253937
24MP0002009_preneoplasia1.79303382
25MP0000579_abnormal_nail_morphology1.78897590
26MP0002138_abnormal_hepatobiliary_system1.78869396
27MP0001873_stomach_inflammation1.77622722
28MP0005451_abnormal_body_composition1.71636886
29MP0005409_darkened_coat_color1.68531457
30MP0005083_abnormal_biliary_tract1.64363171
31MP0006082_CNS_inflammation1.62743144
32MP0010352_gastrointestinal_tract_polyps1.60412332
33MP0009703_decreased_birth_body1.57839194
34MP0003787_abnormal_imprinting1.57572392
35MP0002089_abnormal_postnatal_growth/wei1.53998970
36MP0000685_abnormal_immune_system1.53479276
37MP0010234_abnormal_vibrissa_follicle1.53109887
38MP0005248_abnormal_Harderian_gland1.51876492
39MP0001666_abnormal_nutrient_absorption1.51214280
40MP0003705_abnormal_hypodermis_morpholog1.48606926
41MP0010329_abnormal_lipoprotein_level1.46447546
42MP0003195_calcinosis1.44046500
43MP0003191_abnormal_cellular_cholesterol1.43319098
44MP0000609_abnormal_liver_physiology1.42745563
45MP0005058_abnormal_lysosome_morphology1.38553960
46MP0002166_altered_tumor_susceptibility1.37591456
47MP0004019_abnormal_vitamin_homeostasis1.37566805
48MP0004858_abnormal_nervous_system1.36939416
49MP0004264_abnormal_extraembryonic_tissu1.35001061
50MP0002909_abnormal_adrenal_gland1.34963826
51MP0003566_abnormal_cell_adhesion1.29493397
52MP0005332_abnormal_amino_acid1.29028959
53MP0005076_abnormal_cell_differentiation1.27968363
54MP0004947_skin_inflammation1.27813357
55MP0010368_abnormal_lymphatic_system1.26024961
56MP0002118_abnormal_lipid_homeostasis1.24865785
57MP0002060_abnormal_skin_morphology1.24623794
58MP0003303_peritoneal_inflammation1.18101228
59MP0010678_abnormal_skin_adnexa1.17737607
60MP0004185_abnormal_adipocyte_glucose1.17602505
61MP0001346_abnormal_lacrimal_gland1.14616370
62MP0000778_abnormal_nervous_system1.13114662
63MP0000537_abnormal_urethra_morphology1.11878907
64MP0000462_abnormal_digestive_system1.11376560
65MP0002098_abnormal_vibrissa_morphology1.10154127
66MP0003300_gastrointestinal_ulcer1.09828423
67MP0009053_abnormal_anal_canal1.08909857
68MP0001545_abnormal_hematopoietic_system1.04499100
69MP0005397_hematopoietic_system_phenotyp1.04499100
70MP0005501_abnormal_skin_physiology1.03643573
71MP0004859_abnormal_synaptic_plasticity1.00585739
72MP0001293_anophthalmia0.99443184
73MP0000467_abnormal_esophagus_morphology0.98685802
74MP0005319_abnormal_enzyme/_coenzyme0.97940856
75MP0003890_abnormal_embryonic-extraembry0.97584133
76MP0008877_abnormal_DNA_methylation0.97580648
77MP0003656_abnormal_erythrocyte_physiolo0.97056598
78MP0002282_abnormal_trachea_morphology0.96339435
79MP0005647_abnormal_sex_gland0.95056546
80MP0003045_fibrosis0.94612561
81MP0001984_abnormal_olfaction0.94443083
82MP0002088_abnormal_embryonic_growth/wei0.93768813
83MP0001340_abnormal_eyelid_morphology0.93270273
84MP0001730_embryonic_growth_arrest0.93065846
85MP0003329_amyloid_beta_deposits0.92475020
86MP0003984_embryonic_growth_retardation0.92383965
87MP0003950_abnormal_plasma_membrane0.91945405
88MP0000383_abnormal_hair_follicle0.91894416
89MP0000470_abnormal_stomach_morphology0.91710662
90MP0005377_hearing/vestibular/ear_phenot0.90951606
91MP0003878_abnormal_ear_physiology0.90951606
92MP0005023_abnormal_wound_healing0.90670028
93MP0001672_abnormal_embryogenesis/_devel0.88628695
94MP0005380_embryogenesis_phenotype0.88628695
95MP0003828_pulmonary_edema0.86717221
96MP0003183_abnormal_peptide_metabolism0.86347597
97MP0000371_diluted_coat_color0.85516262
98MP0005423_abnormal_somatic_nervous0.85128200
99MP0003075_altered_response_to0.84862349
100MP0001919_abnormal_reproductive_system0.84650013
101MP0000762_abnormal_tongue_morphology0.84008808
102MP0000003_abnormal_adipose_tissue0.83744350
103MP0002006_tumorigenesis0.83324694
104MP0001440_abnormal_grooming_behavior0.82922059
105MP0003690_abnormal_glial_cell0.82681065
106MP0002249_abnormal_larynx_morphology0.81608423
107MP0001216_abnormal_epidermal_layer0.81549112
108MP0002971_abnormal_brown_adipose0.79816306
109MP0002405_respiratory_system_inflammati0.78771781
110MP0002086_abnormal_extraembryonic_tissu0.77729841
111MP0000598_abnormal_liver_morphology0.76840989
112MP0003315_abnormal_perineum_morphology0.76793230
113MP0010155_abnormal_intestine_physiology0.75940159
114MP0002084_abnormal_developmental_patter0.75320195
115MP0005666_abnormal_adipose_tissue0.74056591
116MP0008995_early_reproductive_senescence0.73211423
117MP0003567_abnormal_fetal_cardiomyocyte0.73154863
118MP0004233_abnormal_muscle_weight0.72883836
119MP0004130_abnormal_muscle_cell0.72267439
120MP0009764_decreased_sensitivity_to0.71815897
121MP0003693_abnormal_embryo_hatching0.71011156
122MP0005220_abnormal_exocrine_pancreas0.70234068
123MP0000639_abnormal_adrenal_gland0.70203665
124MP0004197_abnormal_fetal_growth/weight/0.69702296
125MP0002877_abnormal_melanocyte_morpholog0.69678474
126MP0003699_abnormal_female_reproductive0.69496247
127MP0005367_renal/urinary_system_phenotyp0.69287183
128MP0000516_abnormal_urinary_system0.69287183
129MP0005464_abnormal_platelet_physiology0.68127828
130MP0005375_adipose_tissue_phenotype0.68063593
131MP0009931_abnormal_skin_appearance0.67944551
132MP0003172_abnormal_lysosome_physiology0.67859642
133MP0001915_intracranial_hemorrhage0.67530713
134MP0005408_hypopigmentation0.67311048
135MP0010630_abnormal_cardiac_muscle0.67226719
136MP0003091_abnormal_cell_migration0.65786720
137MP0003861_abnormal_nervous_system0.65019491
138MP0004381_abnormal_hair_follicle0.64942297
139MP0009115_abnormal_fat_cell0.64585337
140MP0001790_abnormal_immune_system0.64322747
141MP0005387_immune_system_phenotype0.64322747
142MP0001348_abnormal_lacrimal_gland0.63942623
143MP0000920_abnormal_myelination0.63883044
144MP0003436_decreased_susceptibility_to0.63795897
145MP0000367_abnormal_coat/_hair0.62868846
146MP0000343_altered_response_to0.62562707
147MP0002168_other_aberrant_phenotype0.62432742
148MP0002697_abnormal_eye_size0.62370833
149MP0000377_abnormal_hair_follicle0.62110076
150MP0003119_abnormal_digestive_system0.61650905
151MP0000627_abnormal_mammary_gland0.61042413
152MP0000350_abnormal_cell_proliferation0.59427553
153MP0003115_abnormal_respiratory_system0.59286801

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.06980904
2Vertebral arch anomaly (HP:0008438)4.51548248
3Asymmetry of the thorax (HP:0001555)4.46817607
4Deep venous thrombosis (HP:0002625)4.30033800
5Alopecia of scalp (HP:0002293)4.26282740
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.18383982
7Hypochromic microcytic anemia (HP:0004840)4.12246141
8Turricephaly (HP:0000262)4.08736424
9Thoracic kyphosis (HP:0002942)4.06132286
10Hypobetalipoproteinemia (HP:0003563)3.94541750
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.93923408
12Pustule (HP:0200039)3.79606668
13Myocardial infarction (HP:0001658)3.75024676
14Macroorchidism (HP:0000053)3.68531718
15Xanthomatosis (HP:0000991)3.67505685
16Ulnar bowing (HP:0003031)3.63705626
17Coronal craniosynostosis (HP:0004440)3.58597030
18Abnormality of the thoracic spine (HP:0100711)3.51020206
19Bronchomalacia (HP:0002780)3.30710543
20Epidermoid cyst (HP:0200040)3.23196637
21Increased IgM level (HP:0003496)3.14403424
22Concave nail (HP:0001598)3.10832506
23Hepatoblastoma (HP:0002884)3.04003444
24Flat acetabular roof (HP:0003180)3.02554352
25Hypolipoproteinemia (HP:0010981)2.91807562
26Partial agenesis of the corpus callosum (HP:0001338)2.90794527
27Vaginal fistula (HP:0004320)2.90616344
28Prolonged partial thromboplastin time (HP:0003645)2.87976289
29Esophageal varix (HP:0002040)2.86082742
30Fat malabsorption (HP:0002630)2.83759848
31Rib fusion (HP:0000902)2.80776190
32Complement deficiency (HP:0004431)2.74689048
33Rectovaginal fistula (HP:0000143)2.73749645
34Rectal fistula (HP:0100590)2.73749645
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72111676
36Long palpebral fissure (HP:0000637)2.70498884
37Osteomalacia (HP:0002749)2.69816710
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.68275733
39Long foot (HP:0001833)2.63683215
40Anal stenosis (HP:0002025)2.63523549
41Polycythemia (HP:0001901)2.59836850
42Abnormal hemoglobin (HP:0011902)2.59744124
43Alacrima (HP:0000522)2.55132903
44Premature skin wrinkling (HP:0100678)2.55048120
45Hyperlipoproteinemia (HP:0010980)2.53113332
46Intestinal fistula (HP:0100819)2.50605883
47Hyperammonemia (HP:0001987)2.49627181
48Joint hemorrhage (HP:0005261)2.42313945
49Supernumerary ribs (HP:0005815)2.42064895
50Male infertility (HP:0003251)2.40465813
51Steatorrhea (HP:0002570)2.38599843
52Tracheomalacia (HP:0002779)2.37509081
53Hypoalphalipoproteinemia (HP:0003233)2.36932691
54Exotropia (HP:0000577)2.35522183
55Heterotopia (HP:0002282)2.34945003
56Oligodontia (HP:0000677)2.34147425
57Termporal pattern (HP:0011008)2.28794802
58Insidious onset (HP:0003587)2.28794802
59Sparse lateral eyebrow (HP:0005338)2.28470804
60Abnormality of complement system (HP:0005339)2.27625976
61Abnormality of the fingertips (HP:0001211)2.26804391
62Pancreatic islet-cell hyperplasia (HP:0004510)2.26375905
63Deviation of the thumb (HP:0009603)2.26371641
64Advanced eruption of teeth (HP:0006288)2.26027298
65Nasal speech (HP:0001611)2.25638982
66Abnormality of the lumbar spine (HP:0100712)2.24394171
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.24016983
68Peripheral demyelination (HP:0011096)2.21365358
69Abnormal tarsal ossification (HP:0008369)2.21007829
70Ketosis (HP:0001946)2.20798438
71Parakeratosis (HP:0001036)2.20365967
72Hypotrichosis (HP:0001006)2.19755935
73Overlapping toe (HP:0001845)2.19490244
74Abnormality of the hepatic vasculature (HP:0006707)2.19137306
75Short humerus (HP:0005792)2.18710493
76Germ cell neoplasia (HP:0100728)2.17331419
77Facial hemangioma (HP:0000329)2.14048466
78Abnormal enzyme/coenzyme activity (HP:0012379)2.13685595
79Vascular calcification (HP:0004934)2.11930143
80Segmental peripheral demyelination/remyelination (HP:0003481)2.11651402
81Abnormality of the common coagulation pathway (HP:0010990)2.10975873
82Abnormality of proline metabolism (HP:0010907)2.10839869
83Hydroxyprolinuria (HP:0003080)2.10839869
84Malnutrition (HP:0004395)2.10419765
85Dysmetric saccades (HP:0000641)2.09410440
86Anteriorly placed anus (HP:0001545)2.09309200
87Persistence of primary teeth (HP:0006335)2.07864019
88Right ventricular cardiomyopathy (HP:0011663)2.07695497
89Proximal placement of thumb (HP:0009623)2.07114389
90Abnormal pancreas size (HP:0012094)2.06317443
91Broad nasal tip (HP:0000455)2.05926385
92Progressive sensorineural hearing impairment (HP:0000408)2.05121685
93Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04150040
94Vertebral hypoplasia (HP:0008417)2.04150040
95Mucopolysacchariduria (HP:0008155)2.03080958
96Urinary glycosaminoglycan excretion (HP:0003541)2.03080958
97Papillary thyroid carcinoma (HP:0002895)2.03072817
98Palmoplantar hyperkeratosis (HP:0000972)2.01227313
99Abnormality of alkaline phosphatase activity (HP:0004379)2.01221104
100Increased mean platelet volume (HP:0011877)1.99560148
101Abnormality of methionine metabolism (HP:0010901)1.98433177
102Natal tooth (HP:0000695)1.98342946
103Amyloidosis (HP:0011034)1.97992527
104Bowed forearm bones (HP:0003956)1.97937664
105Bowing of the arm (HP:0006488)1.97937664
106Glomerulonephritis (HP:0000099)1.97510949
107Gingival bleeding (HP:0000225)1.97210114
108Supernumerary bones of the axial skeleton (HP:0009144)1.96946938
109Abnormality of male internal genitalia (HP:0000022)1.96906646
110Abnormality of the distal phalanx of the thumb (HP:0009617)1.96752760
111Abnormality of the gastric mucosa (HP:0004295)1.96459560
112Thick eyebrow (HP:0000574)1.96252812
113Hypochromic anemia (HP:0001931)1.95781469
114Lip pit (HP:0100267)1.95661054
115Preauricular skin tag (HP:0000384)1.95083023
116Increased CSF protein (HP:0002922)1.94371039
117Nephritis (HP:0000123)1.94158869
118Abnormality of the nasal septum (HP:0000419)1.93702176
119Neonatal hypoglycemia (HP:0001998)1.92710301
120Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92669549
121Tongue fasciculations (HP:0001308)1.92043332
122Recurrent gram-negative bacterial infections (HP:0005420)1.91832767
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91311411
124Disproportionate tall stature (HP:0001519)1.90919918
125Hypercholesterolemia (HP:0003124)1.90258000
126Cardiovascular calcification (HP:0011915)1.90172054
127Volvulus (HP:0002580)1.90021324
128Large for gestational age (HP:0001520)1.89024364
129Decreased lacrimation (HP:0000633)1.88215302
130Abnormality of the incisor (HP:0000676)1.88003372
131Palmar hyperkeratosis (HP:0010765)1.87909545
132Obsessive-compulsive behavior (HP:0000722)1.86858078
133Abnormality of glycine metabolism (HP:0010895)1.86020897
134Abnormality of serine family amino acid metabolism (HP:0010894)1.86020897
135Abnormal number of incisors (HP:0011064)1.85732325
136Thickened calvaria (HP:0002684)1.85433850
137Aplasia/hypoplasia of the humerus (HP:0006507)1.85225075
138Ketoacidosis (HP:0001993)1.84828706
139Hyperglycinemia (HP:0002154)1.83695225
140Hip dysplasia (HP:0001385)1.83440288
141Clumsiness (HP:0002312)1.83311218
142Hepatocellular carcinoma (HP:0001402)1.83078329
143Abnormality of polysaccharide metabolism (HP:0011012)1.83069445
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83069445
145Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83069445
146Muscle fibrillation (HP:0010546)1.82901395
147Hyperglycinuria (HP:0003108)1.82395602
148Septate vagina (HP:0001153)1.82250525
149Small epiphyses (HP:0010585)1.82177851
150Plantar hyperkeratosis (HP:0007556)1.82091468
151Supernumerary nipples (HP:0002558)1.81207659
152Homocystinuria (HP:0002156)1.81158616
153Abnormality of homocysteine metabolism (HP:0010919)1.81158616
154Annular pancreas (HP:0001734)1.80897420
155IgA deficiency (HP:0002720)1.80889187
156Rickets (HP:0002748)1.80129364
157Diaphragmatic weakness (HP:0009113)1.79949743
158Colitis (HP:0002583)1.79744119
159Depressed nasal tip (HP:0000437)1.78380731
160Low posterior hairline (HP:0002162)1.77662969
161Acanthocytosis (HP:0001927)1.76474404
162Pointed chin (HP:0000307)1.76189950
163Missing ribs (HP:0000921)1.75350668
164Skin tags (HP:0010609)1.72680456
165Shawl scrotum (HP:0000049)1.67604956
166Proximal tubulopathy (HP:0000114)1.66427433
167Subacute progressive viral hepatitis (HP:0006572)1.64215281
168Deep philtrum (HP:0002002)1.62609892
169Bifid scrotum (HP:0000048)1.61740410
170Protruding tongue (HP:0010808)1.61117830
171Abnormality of the salivary glands (HP:0010286)1.60391280
172Abnormality of carpal bone ossification (HP:0006257)1.59975880
173Low anterior hairline (HP:0000294)1.59789568
174Curly hair (HP:0002212)1.57847124
175Sex reversal (HP:0012245)1.57828948
176Abnormal sex determination (HP:0012244)1.57828948
177External ophthalmoplegia (HP:0000544)1.57560162
178Conjugated hyperbilirubinemia (HP:0002908)1.57210834
179Enlarged penis (HP:0000040)1.56933383
180Scanning speech (HP:0002168)1.55686391
181Labial hypoplasia (HP:0000066)1.55107073
182Absent eyebrow (HP:0002223)1.53311269
183Menstrual irregularities (HP:0000858)1.53285636
184Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52192050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.66347577
2ICK5.13189604
3MAPK154.00727556
4DDR23.83473276
5MAP3K63.01881680
6EEF2K2.84394523
7FGR2.61475637
8FGFR32.42774406
9EPHB12.34032911
10MAP3K112.30665952
11BMX2.29354704
12MATK2.25327764
13CAMK1G2.25150309
14CSK2.21798425
15TYRO32.15211064
16EPHA22.02241941
17IRAK41.98070029
18LATS11.82480178
19TRPM71.75108391
20DYRK1B1.74270990
21PINK11.73851332
22SMG11.67788632
23MAP3K141.66872776
24STK391.66475953
25STK31.59913482
26TNIK1.58068708
27SIK11.56963846
28PDGFRA1.55816453
29SIK21.54287480
30CDK61.51369378
31PIM21.51242650
32PKN21.48984313
33SGK21.41127524
34MET1.39693877
35RPS6KA21.36635748
36GSK3A1.33805042
37FGFR41.29903880
38ALK1.29570704
39ERBB41.28503158
40SGK4941.26003575
41SGK2231.26003575
42YES11.23764216
43TRIB31.20440067
44PRKD21.20419831
45SGK31.20052103
46PIM11.17947853
47CAMKK11.17773155
48BRD41.12663120
49CDK121.08610477
50RIPK11.07408105
51ERN11.06138294
52EPHA31.05639493
53PRKCH1.04956556
54NLK1.04918754
55AKT31.04271013
56IKBKB1.01112044
57CHUK0.99677525
58UHMK10.99208975
59CASK0.98073148
60IRAK30.95303787
61MAP3K100.93612200
62STK240.92600420
63STK100.91377559
64MARK20.89316348
65PTK60.88686657
66PASK0.87534416
67TBK10.85898367
68PRKAA20.84727556
69PDGFRB0.84365323
70MAPK110.84258402
71PIK3CA0.84128012
72MKNK20.83835730
73OXSR10.81888437
74MTOR0.81023943
75TYK20.80583457
76PDPK10.80112882
77NEK60.79531528
78RET0.77747061
79PTK20.76872610
80CSNK1E0.75849101
81JAK20.74994065
82PBK0.74009840
83CDK70.70625707
84HIPK20.68444691
85LATS20.67725391
86RPS6KB10.66740854
87PDK10.66165365
88TAOK30.65541973
89EGFR0.64278874
90PRKCZ0.63247151
91MST1R0.61772635
92PRKAA10.61621530
93RPS6KC10.60899858
94RPS6KL10.60899858
95MST40.59687693
96PDK20.59423500
97CDK40.59207945
98CDC42BPA0.57856884
99EPHB20.56715582
100SGK10.56558272
101CAMK1D0.56552572
102RPS6KA60.56434856
103CSNK1G10.55138109
104CAMK2G0.54362410
105JAK10.52112181
106DMPK0.51802379
107RPS6KB20.51163528
108MAP3K30.50961553
109MAP2K20.50855717
110ABL10.50690487
111BCR0.49711575
112MELK0.49352578
113WNK40.49326313
114RPS6KA10.48956935
115KSR20.48950527
116PRPF4B0.47823357
117PNCK0.47651096
118FGFR20.47407372
119BLK0.47235747
120PHKG20.46697756
121PHKG10.46697756
122STK38L0.44690432
123CAMK40.44346095
124PRKD10.42758626
125GSK3B0.42573942
126CDK20.42266241
127CSNK1A1L0.42132446
128JAK30.41959943
129INSR0.41335454
130IKBKE0.40246339
131STK110.39659563
132MAPK140.39493217
133ERBB20.37932584
134MAPKAPK20.37631161
135MAP4K10.37267873
136STK160.36666259
137* MAPK10.36098006
138BCKDK0.35638088
139IRAK10.35630416
140NEK90.34179195
141CDK50.33908022
142PKN10.33596178
143MAPK30.33445101
144MAPK120.33279015
145CAMK2D0.33149653
146FGFR10.33030255
147CHEK10.32599596
148MAPK100.32447234
149PAK30.32372336
150WNK10.31446006

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.47345647
2Nitrogen metabolism_Homo sapiens_hsa009102.95847732
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.85451356
4Arginine biosynthesis_Homo sapiens_hsa002202.59395131
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49117677
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41431579
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41254303
8Steroid biosynthesis_Homo sapiens_hsa001002.18467746
9Fatty acid metabolism_Homo sapiens_hsa012122.15498618
10Complement and coagulation cascades_Homo sapiens_hsa046102.05241185
11Staphylococcus aureus infection_Homo sapiens_hsa051502.03219225
12Endometrial cancer_Homo sapiens_hsa052131.93472925
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78275431
14Tryptophan metabolism_Homo sapiens_hsa003801.75570450
15Histidine metabolism_Homo sapiens_hsa003401.73031832
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69013545
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63015957
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62747385
19Arginine and proline metabolism_Homo sapiens_hsa003301.62584173
20Fatty acid elongation_Homo sapiens_hsa000621.60948058
21Fatty acid degradation_Homo sapiens_hsa000711.60110410
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.57460682
23Folate biosynthesis_Homo sapiens_hsa007901.50077055
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46202649
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43588428
26Chemical carcinogenesis_Homo sapiens_hsa052041.43326653
27PPAR signaling pathway_Homo sapiens_hsa033201.39574018
28Prostate cancer_Homo sapiens_hsa052151.32852642
29Lysine degradation_Homo sapiens_hsa003101.31095872
30Retinol metabolism_Homo sapiens_hsa008301.30996650
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.30835850
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26311938
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23141359
34Thyroid cancer_Homo sapiens_hsa052161.21091708
35Selenocompound metabolism_Homo sapiens_hsa004501.18509633
36Ovarian steroidogenesis_Homo sapiens_hsa049131.18325986
37Peroxisome_Homo sapiens_hsa041461.17755633
38Fat digestion and absorption_Homo sapiens_hsa049751.11399652
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08878465
40ABC transporters_Homo sapiens_hsa020101.08643913
41ErbB signaling pathway_Homo sapiens_hsa040121.05943667
42Non-small cell lung cancer_Homo sapiens_hsa052231.05679422
43Starch and sucrose metabolism_Homo sapiens_hsa005001.05509924
44Colorectal cancer_Homo sapiens_hsa052101.05393309
45Prolactin signaling pathway_Homo sapiens_hsa049171.03360646
46Butanoate metabolism_Homo sapiens_hsa006501.01334677
47Choline metabolism in cancer_Homo sapiens_hsa052311.00684242
48beta-Alanine metabolism_Homo sapiens_hsa004100.98116170
49Propanoate metabolism_Homo sapiens_hsa006400.97919566
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97435712
51Sulfur metabolism_Homo sapiens_hsa009200.96304459
52Renal cell carcinoma_Homo sapiens_hsa052110.96273195
53Insulin signaling pathway_Homo sapiens_hsa049100.95505310
54Sulfur relay system_Homo sapiens_hsa041220.95376730
55Notch signaling pathway_Homo sapiens_hsa043300.95279794
56Biosynthesis of amino acids_Homo sapiens_hsa012300.94408960
57Adherens junction_Homo sapiens_hsa045200.93413534
58Glucagon signaling pathway_Homo sapiens_hsa049220.92457805
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91158616
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.91068647
61Phenylalanine metabolism_Homo sapiens_hsa003600.90128809
62Glutathione metabolism_Homo sapiens_hsa004800.89968027
63FoxO signaling pathway_Homo sapiens_hsa040680.89754907
64Caffeine metabolism_Homo sapiens_hsa002320.89402559
65Dorso-ventral axis formation_Homo sapiens_hsa043200.89025391
66Bile secretion_Homo sapiens_hsa049760.88427500
67Vitamin digestion and absorption_Homo sapiens_hsa049770.87865179
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87614588
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85458426
70Hippo signaling pathway_Homo sapiens_hsa043900.84513830
71AMPK signaling pathway_Homo sapiens_hsa041520.84292941
72Pancreatic secretion_Homo sapiens_hsa049720.84031844
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83940112
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83861502
75Chronic myeloid leukemia_Homo sapiens_hsa052200.83409664
76TGF-beta signaling pathway_Homo sapiens_hsa043500.79779302
77Thyroid hormone synthesis_Homo sapiens_hsa049180.79574361
78Prion diseases_Homo sapiens_hsa050200.79477987
79Legionellosis_Homo sapiens_hsa051340.78423703
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.77665205
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77260505
82Malaria_Homo sapiens_hsa051440.77077103
83Inositol phosphate metabolism_Homo sapiens_hsa005620.75590701
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75243013
85VEGF signaling pathway_Homo sapiens_hsa043700.74979630
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.74037688
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.72310946
88mRNA surveillance pathway_Homo sapiens_hsa030150.71989639
89Tyrosine metabolism_Homo sapiens_hsa003500.70541231
90Estrogen signaling pathway_Homo sapiens_hsa049150.67992337
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.67711551
92T cell receptor signaling pathway_Homo sapiens_hsa046600.66347325
93Hedgehog signaling pathway_Homo sapiens_hsa043400.63816109
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62939571
95Small cell lung cancer_Homo sapiens_hsa052220.62872872
96mTOR signaling pathway_Homo sapiens_hsa041500.62593580
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62512405
98Bladder cancer_Homo sapiens_hsa052190.61237949
99Pancreatic cancer_Homo sapiens_hsa052120.60681654
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.60535920
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60527581
102Circadian rhythm_Homo sapiens_hsa047100.59993088
103Renin-angiotensin system_Homo sapiens_hsa046140.58818523
104Axon guidance_Homo sapiens_hsa043600.58707828
105Measles_Homo sapiens_hsa051620.57762682
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.57713916
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57187184
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56466260
109Long-term potentiation_Homo sapiens_hsa047200.56366088
110Tight junction_Homo sapiens_hsa045300.55516567
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55488571
112GnRH signaling pathway_Homo sapiens_hsa049120.55345480
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.54816205
114African trypanosomiasis_Homo sapiens_hsa051430.53836575
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53687001
116Glycerolipid metabolism_Homo sapiens_hsa005610.53021702
117Autoimmune thyroid disease_Homo sapiens_hsa053200.52924071
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52502527
119MicroRNAs in cancer_Homo sapiens_hsa052060.51851952
120Leishmaniasis_Homo sapiens_hsa051400.51740142
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51289138
122Hepatitis B_Homo sapiens_hsa051610.50781123
123Cocaine addiction_Homo sapiens_hsa050300.50064540
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49894901
125Linoleic acid metabolism_Homo sapiens_hsa005910.49612164
126Shigellosis_Homo sapiens_hsa051310.48997911
127Basal cell carcinoma_Homo sapiens_hsa052170.47700548
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45855774
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45300538
130Allograft rejection_Homo sapiens_hsa053300.45130578
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.44821934
132Mineral absorption_Homo sapiens_hsa049780.44713875
133Proteoglycans in cancer_Homo sapiens_hsa052050.43344666
134Asthma_Homo sapiens_hsa053100.41347232
135TNF signaling pathway_Homo sapiens_hsa046680.41087898
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40589983
137Hepatitis C_Homo sapiens_hsa051600.40062947
138Amoebiasis_Homo sapiens_hsa051460.39677121
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38198097
140Graft-versus-host disease_Homo sapiens_hsa053320.37470796
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36518345
142Acute myeloid leukemia_Homo sapiens_hsa052210.35950087
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34754798
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34619377
145B cell receptor signaling pathway_Homo sapiens_hsa046620.34056180
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33910110
147Fructose and mannose metabolism_Homo sapiens_hsa000510.33787663
148Insulin resistance_Homo sapiens_hsa049310.33724555

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