DUSP18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)6.12775114
2motile cilium assembly (GO:0044458)5.84967135
3retinal cone cell development (GO:0046549)4.38246686
4regulation of microtubule-based movement (GO:0060632)4.23372640
5protein polyglutamylation (GO:0018095)4.20525605
6ventricular system development (GO:0021591)4.19943682
7cilium organization (GO:0044782)4.17214595
8pyrimidine nucleobase catabolic process (GO:0006208)4.12502014
9retinal rod cell development (GO:0046548)4.11462407
10protein localization to cilium (GO:0061512)4.00725594
11neural tube formation (GO:0001841)3.94653496
12cilium assembly (GO:0042384)3.94109672
13microtubule bundle formation (GO:0001578)3.86189297
14sperm motility (GO:0030317)3.84892713
15detection of calcium ion (GO:0005513)3.83099086
16multicellular organism reproduction (GO:0032504)3.68987998
17photoreceptor cell maintenance (GO:0045494)3.68581054
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.67298891
19sarcomere organization (GO:0045214)3.64889281
20left/right axis specification (GO:0070986)3.62859168
21aggressive behavior (GO:0002118)3.62654941
22sarcoplasmic reticulum calcium ion transport (GO:0070296)3.52892721
23cilium morphogenesis (GO:0060271)3.48532950
24cardiac myofibril assembly (GO:0055003)3.46550626
25regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.43126371
26nonmotile primary cilium assembly (GO:0035058)3.42335947
27cell communication by electrical coupling (GO:0010644)3.40861599
28negative regulation of mast cell activation (GO:0033004)3.38782557
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.33300787
30regulation of membrane repolarization (GO:0060306)3.32439790
31brain morphogenesis (GO:0048854)3.28674150
32plasma membrane repair (GO:0001778)3.27846458
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21765651
34negative regulation of potassium ion transmembrane transport (GO:1901380)3.16174752
35acrosome reaction (GO:0007340)3.15916226
36neutrophil mediated immunity (GO:0002446)3.15888389
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.14934972
38cellular component assembly involved in morphogenesis (GO:0010927)3.13719767
39nucleobase catabolic process (GO:0046113)3.13555376
40tachykinin receptor signaling pathway (GO:0007217)3.11056788
41positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.08738719
42myofibril assembly (GO:0030239)3.06425022
43cilium movement (GO:0003341)3.05135778
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.98537179
45left/right pattern formation (GO:0060972)2.96407006
46establishment of protein localization to Golgi (GO:0072600)2.95696930
47centriole replication (GO:0007099)2.95144952
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94973070
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94848884
50regulation of synapse structural plasticity (GO:0051823)2.92625613
51microtubule depolymerization (GO:0007019)2.90955784
52vocalization behavior (GO:0071625)2.89868703
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88143409
54cell communication involved in cardiac conduction (GO:0086065)2.85589364
55L-fucose catabolic process (GO:0042355)2.85427879
56fucose catabolic process (GO:0019317)2.85427879
57L-fucose metabolic process (GO:0042354)2.85427879
58DNA deamination (GO:0045006)2.84658622
59behavioral response to nicotine (GO:0035095)2.82512546
60microtubule severing (GO:0051013)2.82481164
61ventricular cardiac muscle cell action potential (GO:0086005)2.81958258
62single strand break repair (GO:0000012)2.81367499
63positive regulation of action potential (GO:0045760)2.79037599
64postsynaptic membrane organization (GO:0001941)2.78958840
65muscle filament sliding (GO:0030049)2.76680952
66actin-myosin filament sliding (GO:0033275)2.76680952
67axonal fasciculation (GO:0007413)2.75003248
68neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.74567987
69membrane repolarization during action potential (GO:0086011)2.73783689
70ubiquinone biosynthetic process (GO:0006744)2.71234183
71tyrosine phosphorylation of STAT protein (GO:0007260)2.68675562
72piRNA metabolic process (GO:0034587)2.67505808
73cardiac conduction (GO:0061337)2.67049582
74protein targeting to Golgi (GO:0000042)2.65555911
75cardiac muscle contraction (GO:0060048)2.65450041
76cerebral cortex radially oriented cell migration (GO:0021799)2.64899634
77Golgi transport vesicle coating (GO:0048200)2.61055577
78COPI coating of Golgi vesicle (GO:0048205)2.61055577
79cell projection assembly (GO:0030031)2.60817896
80relaxation of cardiac muscle (GO:0055119)2.60685143
81reproduction (GO:0000003)2.60167922
82axoneme assembly (GO:0035082)2.60103995
83neuron cell-cell adhesion (GO:0007158)2.59752266
84synaptic vesicle docking involved in exocytosis (GO:0016081)2.58986549
85regulation of skeletal muscle contraction (GO:0014819)2.57623944
86actomyosin structure organization (GO:0031032)2.57573564
87regulation of heart rate by cardiac conduction (GO:0086091)2.56910314
88inositol phosphate catabolic process (GO:0071545)2.55866912
89regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55854209
90fusion of sperm to egg plasma membrane (GO:0007342)2.55401447
91regulation of sarcomere organization (GO:0060297)2.55365972
92base-excision repair, AP site formation (GO:0006285)2.54615630
93ubiquinone metabolic process (GO:0006743)2.54322079
94protein localization to Golgi apparatus (GO:0034067)2.54234229
95adaptation of signaling pathway (GO:0023058)2.54135103
96indole-containing compound catabolic process (GO:0042436)2.53644675
97indolalkylamine catabolic process (GO:0046218)2.53644675
98tryptophan catabolic process (GO:0006569)2.53644675
99microtubule-based movement (GO:0007018)2.50900010
100intraciliary transport (GO:0042073)2.49975052
101cardiac muscle hypertrophy (GO:0003300)2.49610328
102spermatid development (GO:0007286)2.49314930
103myeloid leukocyte mediated immunity (GO:0002444)2.48815651
104actin-mediated cell contraction (GO:0070252)2.47778021
105retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47013623
106preassembly of GPI anchor in ER membrane (GO:0016254)2.46157364
107epithelial cilium movement (GO:0003351)2.45905994
108microglial cell activation (GO:0001774)2.45284339
109pyrimidine dimer repair (GO:0006290)2.44818100
110positive regulation of potassium ion transport (GO:0043268)2.44607230
111photoreceptor cell development (GO:0042461)2.44460105
112positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.42982042
113GPI anchor metabolic process (GO:0006505)2.42435925
114epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41140985
115behavioral response to ethanol (GO:0048149)2.40987843
116urinary tract smooth muscle contraction (GO:0014848)2.40322553
117regulation of cell communication by electrical coupling (GO:0010649)2.39256779
118centriole assembly (GO:0098534)2.38718627
119neuron recognition (GO:0008038)2.38412883
120RNA destabilization (GO:0050779)2.37771734
121striated muscle hypertrophy (GO:0014897)2.37262715
122regulation of action potential (GO:0098900)2.35591145
123regulation of glutamate receptor signaling pathway (GO:1900449)2.35564290
124regulation of MHC class II biosynthetic process (GO:0045346)2.35474719
125regulation of actin filament-based movement (GO:1903115)2.34635296
126dendrite morphogenesis (GO:0048813)2.33710506
127microtubule polymerization or depolymerization (GO:0031109)2.32793245
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.32233601
129cellular extravasation (GO:0045123)2.32219282
130phosphorylated carbohydrate dephosphorylation (GO:0046838)2.31952250
131inositol phosphate dephosphorylation (GO:0046855)2.31952250
132cardiac muscle cell action potential (GO:0086001)2.31805779
133cardiac muscle cell development (GO:0055013)2.31631931
134indolalkylamine metabolic process (GO:0006586)2.31504540
135DNA methylation involved in gamete generation (GO:0043046)2.31129867
136phosphatidylethanolamine metabolic process (GO:0046337)2.31024834
137regulation of collateral sprouting (GO:0048670)2.30806106
138striated muscle contraction (GO:0006941)2.30561901
139eye photoreceptor cell development (GO:0042462)2.30216839
140regulation of short-term neuronal synaptic plasticity (GO:0048172)2.29820634
141phosphatidylethanolamine biosynthetic process (GO:0006646)2.29030451
142cardiac muscle cell action potential involved in contraction (GO:0086002)2.28436012
143establishment of nucleus localization (GO:0040023)2.28425895
144synaptic vesicle exocytosis (GO:0016079)2.27617922
145cellular biogenic amine catabolic process (GO:0042402)2.27425063
146amine catabolic process (GO:0009310)2.27425063
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27123039
148detection of light stimulus involved in visual perception (GO:0050908)2.27103450
149detection of light stimulus involved in sensory perception (GO:0050962)2.27103450
150mannosylation (GO:0097502)2.27020361
151membrane repolarization (GO:0086009)2.26908529
152cilium or flagellum-dependent cell motility (GO:0001539)2.26649311
153olfactory bulb development (GO:0021772)2.26298456
154regulation of synaptic vesicle exocytosis (GO:2000300)2.26142653
155response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.24566055
156regulation of calcium ion transmembrane transport (GO:1903169)2.24051953
157regulation of calcium ion transmembrane transporter activity (GO:1901019)2.24051953
158single fertilization (GO:0007338)2.23896230
159sialylation (GO:0097503)2.23790597
160dendritic spine morphogenesis (GO:0060997)2.23423602
161positive regulation of vesicle fusion (GO:0031340)2.23271767
162regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.22441885
163response to pheromone (GO:0019236)2.21914848
164insulin secretion (GO:0030073)2.21554619
165activation of protein kinase A activity (GO:0034199)2.21461161
166regulation of potassium ion transmembrane transport (GO:1901379)2.21408827
167type B pancreatic cell development (GO:0003323)2.20728440
168positive regulation of potassium ion transmembrane transport (GO:1901381)2.20724641
169cardiac cell development (GO:0055006)2.20129376
170platelet dense granule organization (GO:0060155)2.19942619
171cellular ketone body metabolic process (GO:0046950)2.19840881
172somite development (GO:0061053)2.19718291
173regulation of synaptic vesicle transport (GO:1902803)2.19581036
174tryptophan metabolic process (GO:0006568)2.19544655
175growth hormone secretion (GO:0030252)2.17577298
176regulation of striated muscle contraction (GO:0006942)2.17368616
177positive regulation of synapse maturation (GO:0090129)2.17284740
178sperm-egg recognition (GO:0035036)2.16625683
179presynaptic membrane assembly (GO:0097105)2.15945232
180regulation of cAMP-dependent protein kinase activity (GO:2000479)2.15578260
181axonemal dynein complex assembly (GO:0070286)2.15459605
182regulation of type B pancreatic cell apoptotic process (GO:2000674)2.15037319
183presynaptic membrane organization (GO:0097090)2.14817351
184auditory behavior (GO:0031223)2.14251451
185glutamate secretion (GO:0014047)2.13919909
186central nervous system projection neuron axonogenesis (GO:0021952)2.13086587
187innervation (GO:0060384)2.12668311
188regulation of energy homeostasis (GO:2000505)2.12564137
189regulation of cilium assembly (GO:1902017)2.12525072
190positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.12066165
191phosphorelay signal transduction system (GO:0000160)2.11890795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03497513
2GBX2_23144817_ChIP-Seq_PC3_Human2.92083352
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30064128
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20702679
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.16090830
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11088170
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10147739
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08037050
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00952871
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00952871
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99709293
12TAF15_26573619_Chip-Seq_HEK293_Human1.95040773
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94184508
14RNF2_27304074_Chip-Seq_ESCs_Mouse1.93482390
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93316237
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93302106
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.92756480
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90446263
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90391653
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.89924569
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89601993
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.88003421
23CBP_20019798_ChIP-Seq_JUKART_Human1.78002310
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.78002310
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71874497
26ER_23166858_ChIP-Seq_MCF-7_Human1.71696317
27REST_21632747_ChIP-Seq_MESCs_Mouse1.70928834
28DROSHA_22980978_ChIP-Seq_HELA_Human1.69455356
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68841241
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68090231
31SMAD4_21799915_ChIP-Seq_A2780_Human1.67823377
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64515818
33AR_21572438_ChIP-Seq_LNCaP_Human1.62787547
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.62379386
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60772631
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60037580
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55008287
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.52750169
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52472972
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52381490
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51099257
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50227933
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.50097112
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.49841144
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48046755
46FUS_26573619_Chip-Seq_HEK293_Human1.47844200
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46092162
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44669551
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44149751
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42536530
51ZNF274_21170338_ChIP-Seq_K562_Hela1.42458882
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.41558091
53VDR_22108803_ChIP-Seq_LS180_Human1.41423563
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40930727
55P300_19829295_ChIP-Seq_ESCs_Human1.39996138
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.39214204
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.38646050
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38619035
59TP53_22573176_ChIP-Seq_HFKS_Human1.37854671
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.36688007
61IRF1_19129219_ChIP-ChIP_H3396_Human1.34580954
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34056262
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.33031160
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32949546
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.31999855
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31999838
67AHR_22903824_ChIP-Seq_MCF-7_Human1.31750617
68EWS_26573619_Chip-Seq_HEK293_Human1.31617002
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.31462496
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.31356376
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28138545
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27796804
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26879419
74* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26678475
75STAT3_23295773_ChIP-Seq_U87_Human1.26356821
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26112082
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.25410878
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24581870
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22985063
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22768083
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.22742176
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20714484
83SOX2_19829295_ChIP-Seq_ESCs_Human1.20417100
84NANOG_19829295_ChIP-Seq_ESCs_Human1.20417100
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.20161011
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19971995
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.18693513
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.18293330
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17650035
90BCAT_22108803_ChIP-Seq_LS180_Human1.17392519
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15789628
92TP53_18474530_ChIP-ChIP_U2OS_Human1.15226364
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15052593
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.14665953
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13894608
96AR_25329375_ChIP-Seq_VCAP_Human1.13761595
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13309295
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13292518
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12966294
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12963276
101RNF2_27304074_Chip-Seq_NSC_Mouse1.12552973
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10777420
103* AR_19668381_ChIP-Seq_PC3_Human1.10501602
104RXR_22108803_ChIP-Seq_LS180_Human1.10273607
105NCOR_22424771_ChIP-Seq_293T_Human1.09901062
106SMRT_27268052_Chip-Seq_Bcells_Human1.08963969
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08273274
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07957095
109GATA3_26560356_Chip-Seq_TH2_Human1.06498452
110NANOG_20526341_ChIP-Seq_ESCs_Human1.06485408
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06441275
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06124675
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06058098
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.06028828
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05978890
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05535549
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05380881
118RUNX2_22187159_ChIP-Seq_PCA_Human1.05138854
119FOXA1_25329375_ChIP-Seq_VCAP_Human1.04444221
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04444221
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04435776
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04208751
123AR_20517297_ChIP-Seq_VCAP_Human1.04202272
124ISL1_27105846_Chip-Seq_CPCs_Mouse1.04058242
125TCF4_22108803_ChIP-Seq_LS180_Human1.03772009
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03709380
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03606542
128* TCF4_23295773_ChIP-Seq_U87_Human1.02975142
129VDR_24787735_ChIP-Seq_THP-1_Human1.02106691
130MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01918326
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99944247
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99428773
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98635383
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97780615
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97767057
136MYC_19829295_ChIP-Seq_ESCs_Human0.97428284
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.97122643
138IGF1R_20145208_ChIP-Seq_DFB_Human0.97045642
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.97034502
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96910451
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96910451
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.96786033
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.96752056
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96149163
145WDR5_24793694_ChIP-Seq_LNCAP_Human0.95235074
146ETV1_20927104_ChIP-Seq_GIST48_Human0.94779427
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94454682
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93985532
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.93687337
150TBX20_22328084_ChIP-Seq_HEART_Mouse0.93686789
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.92710934
152FOXH1_21741376_ChIP-Seq_EPCs_Human0.92551824
153TBL1_22424771_ChIP-Seq_293T_Human0.91750725
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91092613
155ERA_21632823_ChIP-Seq_H3396_Human0.90342241
156RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90203854
157TAL1_26923725_Chip-Seq_HPCs_Mouse0.90088222
158TP53_16413492_ChIP-PET_HCT116_Human0.89932074
159RUNX_20019798_ChIP-Seq_JUKART_Human0.89331777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.40260825
2MP0009780_abnormal_chondrocyte_physiolo3.17222882
3MP0003646_muscle_fatigue3.08241827
4MP0000751_myopathy2.88055175
5MP0004859_abnormal_synaptic_plasticity2.69879008
6MP0008789_abnormal_olfactory_epithelium2.58517011
7MP0005410_abnormal_fertilization2.46717016
8MP0004215_abnormal_myocardial_fiber2.39939448
9MP0003724_increased_susceptibility_to2.36404115
10MP0001529_abnormal_vocalization2.20188269
11MP0004084_abnormal_cardiac_muscle2.19207530
12MP0000749_muscle_degeneration2.19205094
13MP0004270_analgesia2.17130917
14MP0005499_abnormal_olfactory_system2.16409262
15MP0005394_taste/olfaction_phenotype2.16409262
16MP0000569_abnormal_digit_pigmentation2.09670060
17MP0001986_abnormal_taste_sensitivity2.08580588
18MP0002102_abnormal_ear_morphology2.07032417
19MP0002909_abnormal_adrenal_gland2.05491223
20MP0005646_abnormal_pituitary_gland2.03575890
21MP0002277_abnormal_respiratory_mucosa2.02819654
22MP0005551_abnormal_eye_electrophysiolog1.96418929
23MP0004145_abnormal_muscle_electrophysio1.83387116
24MP0004036_abnormal_muscle_relaxation1.82117104
25MP0003635_abnormal_synaptic_transmissio1.72605308
26MP0003303_peritoneal_inflammation1.72123940
27MP0003137_abnormal_impulse_conducting1.71157825
28MP0002234_abnormal_pharynx_morphology1.67353997
29MP0000013_abnormal_adipose_tissue1.66435805
30MP0005187_abnormal_penis_morphology1.63866348
31MP0005253_abnormal_eye_physiology1.63496711
32MP0004142_abnormal_muscle_tone1.63018888
33MP0002972_abnormal_cardiac_muscle1.60944025
34MP0002132_abnormal_respiratory_system1.59212406
35MP0008877_abnormal_DNA_methylation1.58503333
36MP0000778_abnormal_nervous_system1.56779462
37MP0000678_abnormal_parathyroid_gland1.56686447
38MP0002063_abnormal_learning/memory/cond1.56583496
39MP0004085_abnormal_heartbeat1.56304365
40MP0005620_abnormal_muscle_contractility1.55964167
41MP0002877_abnormal_melanocyte_morpholog1.52966667
42MP0004043_abnormal_pH_regulation1.51922701
43MP0001502_abnormal_circadian_rhythm1.49388481
44MP0005084_abnormal_gallbladder_morpholo1.47886190
45MP0002653_abnormal_ependyma_morphology1.45061800
46MP0001984_abnormal_olfaction1.44301071
47MP0002928_abnormal_bile_duct1.42227706
48MP0004233_abnormal_muscle_weight1.41909371
49MP0003787_abnormal_imprinting1.40262598
50MP0001835_abnormal_antigen_presentation1.39771231
51MP0003283_abnormal_digestive_organ1.38556615
52MP0002106_abnormal_muscle_physiology1.38493622
53MP0002734_abnormal_mechanical_nocicepti1.37762097
54MP0004087_abnormal_muscle_fiber1.37650885
55MP0003718_maternal_effect1.37091725
56MP0009764_decreased_sensitivity_to1.36463178
57MP0002638_abnormal_pupillary_reflex1.36391486
58MP0005645_abnormal_hypothalamus_physiol1.35980598
59MP0004484_altered_response_of1.35252074
60MP0010386_abnormal_urinary_bladder1.35098193
61MP0001299_abnormal_eye_distance/1.34746119
62MP0002572_abnormal_emotion/affect_behav1.33616278
63MP0005330_cardiomyopathy1.33183557
64MP0002557_abnormal_social/conspecific_i1.32398926
65MP0000372_irregular_coat_pigmentation1.30293062
66MP0000750_abnormal_muscle_regeneration1.29014944
67MP0000631_abnormal_neuroendocrine_gland1.27936417
68MP0004858_abnormal_nervous_system1.27527090
69MP0000465_gastrointestinal_hemorrhage1.27227337
70MP0003698_abnormal_male_reproductive1.26768741
71MP0004130_abnormal_muscle_cell1.26469906
72MP0001486_abnormal_startle_reflex1.21144450
73MP0005369_muscle_phenotype1.20353218
74MP0008961_abnormal_basal_metabolism1.18926058
75MP0002138_abnormal_hepatobiliary_system1.17010277
76MP0006054_spinal_hemorrhage1.16647188
77MP0008872_abnormal_physiological_respon1.16420292
78MP0008875_abnormal_xenobiotic_pharmacok1.15977803
79MP0003011_delayed_dark_adaptation1.15241373
80MP0006138_congestive_heart_failure1.14904276
81MP0001905_abnormal_dopamine_level1.14324858
82MP0002184_abnormal_innervation1.13953673
83MP0003122_maternal_imprinting1.13835636
84MP0003880_abnormal_central_pattern1.13470154
85MP0006082_CNS_inflammation1.13349900
86MP0000383_abnormal_hair_follicle1.12610633
87MP0005671_abnormal_response_to1.11733899
88MP0001944_abnormal_pancreas_morphology1.11248375
89MP0001929_abnormal_gametogenesis1.10547745
90MP0009250_abnormal_appendicular_skeleto1.10144009
91MP0009745_abnormal_behavioral_response1.08465474
92MP0004133_heterotaxia1.07625975
93MP0001800_abnormal_humoral_immune1.07491233
94MP0002419_abnormal_innate_immunity1.06923361
95MP0000759_abnormal_skeletal_muscle1.05739372
96MP0005310_abnormal_salivary_gland1.05000208
97MP0003195_calcinosis1.04703881
98MP0005167_abnormal_blood-brain_barrier1.04221936
99MP0002896_abnormal_bone_mineralization1.03366404
100MP0009046_muscle_twitch1.02241766
101MP0008775_abnormal_heart_ventricle1.01681487
102MP0001968_abnormal_touch/_nociception1.01567799
103MP0002282_abnormal_trachea_morphology1.00865558
104MP0002693_abnormal_pancreas_physiology1.00776753
105MP0004742_abnormal_vestibular_system1.00203464
106MP0001440_abnormal_grooming_behavior0.99628105
107MP0001963_abnormal_hearing_physiology0.99546610
108MP0005385_cardiovascular_system_phenoty0.98921756
109MP0001544_abnormal_cardiovascular_syste0.98921756
110MP0002127_abnormal_cardiovascular_syste0.97349356
111MP0000003_abnormal_adipose_tissue0.97120106
112MP0001485_abnormal_pinna_reflex0.96679076
113MP0009785_altered_susceptibility_to0.96443604
114MP0006072_abnormal_retinal_apoptosis0.96353403
115MP0003436_decreased_susceptibility_to0.95351496
116MP0006292_abnormal_olfactory_placode0.95264688
117MP0002723_abnormal_immune_serum0.95222971
118MP0002064_seizures0.95062608
119MP0000049_abnormal_middle_ear0.94816277
120MP0002269_muscular_atrophy0.94504566
121MP0005423_abnormal_somatic_nervous0.93670300
122MP0002148_abnormal_hypersensitivity_rea0.93378459
123MP0006276_abnormal_autonomic_nervous0.93204362
124MP0000427_abnormal_hair_cycle0.92970377
125MP0002452_abnormal_antigen_presenting0.92225338
126MP0003183_abnormal_peptide_metabolism0.92038205
127MP0001790_abnormal_immune_system0.91929626
128MP0005387_immune_system_phenotype0.91929626
129MP0008004_abnormal_stomach_pH0.91816024
130MP0001188_hyperpigmentation0.90943350
131MP0000015_abnormal_ear_pigmentation0.89646735
132MP0003879_abnormal_hair_cell0.89013041
133MP0002067_abnormal_sensory_capabilities0.88713929
134MP0009765_abnormal_xenobiotic_induced0.88549931
135MP0005195_abnormal_posterior_eye0.88460499
136MP0002420_abnormal_adaptive_immunity0.87922222
137MP0000747_muscle_weakness0.87772916
138MP0005025_abnormal_response_to0.87496037
139MP0002735_abnormal_chemical_nociception0.86885964
140MP0001819_abnormal_immune_cell0.86248969
141MP0005000_abnormal_immune_tolerance0.86064463
142MP0002405_respiratory_system_inflammati0.85709762
143MP0001324_abnormal_eye_pigmentation0.85566100
144MP0002116_abnormal_craniofacial_bone0.85471013
145MP0002229_neurodegeneration0.85317030
146MP0002822_catalepsy0.85120321
147MP0005083_abnormal_biliary_tract0.83849249
148MP0005257_abnormal_intraocular_pressure0.83042785
149MP0003119_abnormal_digestive_system0.82336145
150MP0002733_abnormal_thermal_nociception0.82255962
151MP0002736_abnormal_nociception_after0.81560633
152MP0001501_abnormal_sleep_pattern0.81201420
153MP0001970_abnormal_pain_threshold0.81121163
154MP0004811_abnormal_neuron_physiology0.80891737
155MP0005377_hearing/vestibular/ear_phenot0.80638430
156MP0003878_abnormal_ear_physiology0.80638430
157MP0004885_abnormal_endolymph0.79546741
158MP0005623_abnormal_meninges_morphology0.79482039
159MP0002882_abnormal_neuron_morphology0.78532466
160MP0010630_abnormal_cardiac_muscle0.76503431
161MP0005386_behavior/neurological_phenoty0.75973803
162MP0004924_abnormal_behavior0.75973803
163MP0000955_abnormal_spinal_cord0.75366378
164MP0002876_abnormal_thyroid_physiology0.74734216
165MP0002272_abnormal_nervous_system0.74452992
166MP0005171_absent_coat_pigmentation0.73259662

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)5.14335325
2Nephronophthisis (HP:0000090)4.35584511
3Tubulointerstitial nephritis (HP:0001970)4.28305616
4Pancreatic cysts (HP:0001737)4.21177143
5Molar tooth sign on MRI (HP:0002419)4.09022661
6Abnormality of midbrain morphology (HP:0002418)4.09022661
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.91816923
8Sudden death (HP:0001699)3.91002879
9Abnormal rod and cone electroretinograms (HP:0008323)3.67859467
10Bronchiectasis (HP:0002110)3.65668521
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.65101130
12Exercise-induced myalgia (HP:0003738)3.61998886
13Abnormality of the renal medulla (HP:0100957)3.61743683
14Atrial fibrillation (HP:0005110)3.55874254
15Abnormal respiratory motile cilium physiology (HP:0012261)3.44472207
16Primary atrial arrhythmia (HP:0001692)3.40705627
17Calf muscle hypertrophy (HP:0008981)3.19711132
18Abnormality of the calf musculature (HP:0001430)3.19276266
19Supraventricular tachycardia (HP:0004755)3.15724586
20Abnormal ciliary motility (HP:0012262)3.10999051
21Supraventricular arrhythmia (HP:0005115)3.07433891
22Nasal polyposis (HP:0100582)3.06013120
23Syncope (HP:0001279)3.03047268
24Occipital encephalocele (HP:0002085)3.00071276
25Prolonged QT interval (HP:0001657)2.94614311
26Muscle hypertrophy of the lower extremities (HP:0008968)2.91521259
27Chronic sinusitis (HP:0011109)2.80618090
28Rhinitis (HP:0012384)2.77257699
29Bony spicule pigmentary retinopathy (HP:0007737)2.74652341
30Ventricular tachycardia (HP:0004756)2.73380565
31Chronic bronchitis (HP:0004469)2.72639335
32Hyperinsulinemic hypoglycemia (HP:0000825)2.72302872
33Absent/shortened dynein arms (HP:0200106)2.72114933
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.72114933
35Muscle fiber splitting (HP:0003555)2.65927374
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63671232
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.59381195
38Tubulointerstitial abnormality (HP:0001969)2.58777826
39Congenital hepatic fibrosis (HP:0002612)2.57109764
40Genital tract atresia (HP:0001827)2.57100563
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.54384676
42Exercise-induced muscle cramps (HP:0003710)2.53729128
43Bundle branch block (HP:0011710)2.53254353
44Hyporeflexia of lower limbs (HP:0002600)2.52103015
45Polyphagia (HP:0002591)2.52024674
46Vaginal atresia (HP:0000148)2.51500316
47Pheochromocytoma (HP:0002666)2.48108175
48Infertility (HP:0000789)2.47655587
49Postaxial foot polydactyly (HP:0001830)2.45278463
50Anencephaly (HP:0002323)2.43344547
51Abnormality of the nasal mucosa (HP:0000433)2.43333530
52Left ventricular hypertrophy (HP:0001712)2.42177047
53Recurrent sinusitis (HP:0011108)2.42011749
54Hypoplastic ischia (HP:0003175)2.41905342
55Focal motor seizures (HP:0011153)2.41047844
56Stomatitis (HP:0010280)2.40924068
57Insulin-resistant diabetes mellitus (HP:0000831)2.39353360
58Abnormal respiratory motile cilium morphology (HP:0005938)2.35604530
59Abnormal respiratory epithelium morphology (HP:0012253)2.35604530
60Tubular atrophy (HP:0000092)2.35108275
61Poor coordination (HP:0002370)2.34921995
62Right ventricular cardiomyopathy (HP:0011663)2.34155004
63Absent speech (HP:0001344)2.29924416
64Attenuation of retinal blood vessels (HP:0007843)2.27771318
65Sclerocornea (HP:0000647)2.27591914
66Abnormal EKG (HP:0003115)2.27475839
67Subaortic stenosis (HP:0001682)2.26989274
68Abnormality of the left ventricular outflow tract (HP:0011103)2.26989274
69Retinal dysplasia (HP:0007973)2.26750468
70Bronchitis (HP:0012387)2.25079282
71Retinitis pigmentosa (HP:0000510)2.23105236
72Constricted visual fields (HP:0001133)2.23079298
73Epileptic encephalopathy (HP:0200134)2.22835339
74Congenital stationary night blindness (HP:0007642)2.22621143
75Absent eyebrow (HP:0002223)2.20132413
76Megalencephaly (HP:0001355)2.19426672
77Elevated erythrocyte sedimentation rate (HP:0003565)2.17126359
78Muscle fiber inclusion bodies (HP:0100299)2.12729827
79Large for gestational age (HP:0001520)2.11631874
80Lipoatrophy (HP:0100578)2.11238378
81Hyperventilation (HP:0002883)2.09734190
82Abnormality of the renal cortex (HP:0011035)2.08170173
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08082977
84Abolished electroretinogram (ERG) (HP:0000550)2.07681464
85Abnormal drinking behavior (HP:0030082)2.06825259
86Polydipsia (HP:0001959)2.06825259
87Myoglobinuria (HP:0002913)2.06437168
88Asymmetric septal hypertrophy (HP:0001670)2.04350830
89Postaxial hand polydactyly (HP:0001162)2.03747997
90Hypoglycemic seizures (HP:0002173)2.02564843
91True hermaphroditism (HP:0010459)2.02502211
92Abnormality of calcium-phosphate metabolism (HP:0100530)2.01639122
93Amyotrophic lateral sclerosis (HP:0007354)2.00069779
94Medial flaring of the eyebrow (HP:0010747)1.99949791
95EMG: myopathic abnormalities (HP:0003458)1.99683611
96Agitation (HP:0000713)1.99081026
97Palpitations (HP:0001962)1.98111376
98Ventricular fibrillation (HP:0001663)1.98066309
99Symptomatic seizures (HP:0011145)1.96998693
100Abnormality of the ischium (HP:0003174)1.96969635
101Ventricular arrhythmia (HP:0004308)1.96639749
102Gait imbalance (HP:0002141)1.96237204
103Type 1 muscle fiber predominance (HP:0003803)1.95503270
104Decreased circulating renin level (HP:0003351)1.94784180
105Neuroendocrine neoplasm (HP:0100634)1.93980529
106Mildly elevated creatine phosphokinase (HP:0008180)1.93785540
107Optic neuritis (HP:0100653)1.93394960
108Retrobulbar optic neuritis (HP:0100654)1.93394960
109Dilated cardiomyopathy (HP:0001644)1.92531126
110Cone-rod dystrophy (HP:0000548)1.90895485
111Lissencephaly (HP:0001339)1.90532806
112Abnormality of macular pigmentation (HP:0008002)1.90380316
113Myositis (HP:0100614)1.90194161
114Severe visual impairment (HP:0001141)1.89760365
115Progressive cerebellar ataxia (HP:0002073)1.88975667
116Visual hallucinations (HP:0002367)1.88730265
117Oculomotor apraxia (HP:0000657)1.86174901
118Hyperkalemia (HP:0002153)1.85560491
119Proximal amyotrophy (HP:0007126)1.85262952
120Increased variability in muscle fiber diameter (HP:0003557)1.85056103
121Hyperglycemia (HP:0003074)1.84534115
122Abnormality of the pubic bones (HP:0003172)1.84417431
123Congenital primary aphakia (HP:0007707)1.83863513
124Specific learning disability (HP:0001328)1.82908699
125Portal hypertension (HP:0001409)1.82807662
126Heart block (HP:0012722)1.82757909
127Abnormal atrioventricular conduction (HP:0005150)1.82403442
128Bell-shaped thorax (HP:0001591)1.82317266
129Polyuria (HP:0000103)1.81845125
130Papillary thyroid carcinoma (HP:0002895)1.81103371
131Male pseudohermaphroditism (HP:0000037)1.80543127
132Limb-girdle muscle atrophy (HP:0003797)1.80460666
133Pancreatic fibrosis (HP:0100732)1.79613759
134Bradycardia (HP:0001662)1.79198813
135Chronic otitis media (HP:0000389)1.78721427
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77677139
137Stage 5 chronic kidney disease (HP:0003774)1.76761712
138Decreased central vision (HP:0007663)1.76638948
139Nemaline bodies (HP:0003798)1.75334371
140Fetal akinesia sequence (HP:0001989)1.73912358
141Cystic hygroma (HP:0000476)1.72345031
142Orchitis (HP:0100796)1.70982166
143Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70034497
144Preaxial hand polydactyly (HP:0001177)1.69437475
145Rimmed vacuoles (HP:0003805)1.69240148
146Myotonia (HP:0002486)1.68804206
147Abnormality of skeletal muscle fiber size (HP:0012084)1.68161415
148Aplasia/Hypoplasia of the lens (HP:0008063)1.64725511
149Difficulty running (HP:0009046)1.63387487
150Genetic anticipation (HP:0003743)1.62754960
151Furrowed tongue (HP:0000221)1.62156706
152Recurrent otitis media (HP:0000403)1.62003592
153Nephrogenic diabetes insipidus (HP:0009806)1.61688766
154Ketoacidosis (HP:0001993)1.61632141
155Abnormal pancreas size (HP:0012094)1.61234219
156Prominent nasal bridge (HP:0000426)1.60875126
157Bronchomalacia (HP:0002780)1.60852025
158Stomach cancer (HP:0012126)1.60638506
159Type II lissencephaly (HP:0007260)1.60619416
160Abnormality of the right ventricle (HP:0001707)1.60027355
161Broad foot (HP:0001769)1.59789474
162Atrioventricular block (HP:0001678)1.59493097
163Abnormality of the hepatic vasculature (HP:0006707)1.59259990
164Nephropathy (HP:0000112)1.57788104
165Broad-based gait (HP:0002136)1.57705742
166Bile duct proliferation (HP:0001408)1.57631252
167Abnormal biliary tract physiology (HP:0012439)1.57631252
168Narrow forehead (HP:0000341)1.56826751
169Tinnitus (HP:0000360)1.55997651
170Gowers sign (HP:0003391)1.55631894
171Central scotoma (HP:0000603)1.55534272
172Asthma (HP:0002099)1.55284137
173Male infertility (HP:0003251)1.55252773
174Cystic liver disease (HP:0006706)1.55185717
175Neoplasm of the adrenal gland (HP:0100631)1.54775664
176Hypoglycemic coma (HP:0001325)1.54647562
177Photophobia (HP:0000613)1.52088592
178Multicystic kidney dysplasia (HP:0000003)1.52057181
179Nephrotic syndrome (HP:0000100)1.51911992
180Aplasia of the phalanges of the hand (HP:0009802)1.51807416
181Aplasia/Hypoplasia of the tibia (HP:0005772)1.50293699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.30683538
2TRIM283.03013537
3ERBB32.68180351
4MARK12.65202570
5PHKG22.54897164
6PHKG12.54897164
7MUSK2.51146346
8NTRK32.46436448
9MAP4K22.43109532
10TAOK32.37102818
11INSRR2.33082665
12TXK2.27571505
13LMTK22.27426024
14CASK2.15720382
15LATS12.13258957
16DMPK2.09696903
17NUAK12.03866195
18OBSCN2.02933406
19SIK32.00282074
20TRIB31.93359077
21ADRBK21.88080173
22KSR11.84672798
23EPHA41.83358279
24NTRK21.77842492
25PASK1.68427950
26PAK31.64865397
27TTN1.62564156
28MAP3K21.51449311
29MAPK151.47965438
30BMPR21.45231299
31PDK31.43212125
32PDK41.43212125
33MAP4K11.39131762
34MAP3K41.38113784
35BCKDK1.36723758
36MAPK131.36443419
37MAP3K91.34330248
38CDC42BPA1.31789991
39TNK21.29778311
40EPHB11.28592801
41MAP2K71.28186964
42PLK21.23309024
43EPHB21.18514298
44STK38L1.18016732
45ZAK1.17079243
46CSNK1G21.16363138
47SGK21.15351745
48CSNK1A1L1.09572043
49KIT1.08631502
50DYRK31.06232335
51MINK11.06143931
52TESK21.05901181
53CAMKK11.05900496
54ACVR1B1.05651293
55DYRK21.02902846
56DAPK21.02117924
57CSNK1G30.98871945
58PRPF4B0.98642375
59LATS20.96064661
60PAK60.95838436
61NME10.95672696
62BLK0.95365151
63FER0.94896845
64RPS6KA20.94315418
65DYRK1A0.93479602
66CAMK2D0.93089650
67WNK40.92886781
68IKBKE0.91763978
69ROCK10.91215532
70EPHA30.89277779
71PRKCE0.88653477
72FES0.88230291
73CSK0.87603076
74BMPR1B0.87284723
75ADRBK10.86107322
76SGK2230.85616290
77SGK4940.85616290
78CAMK2A0.85044781
79PDK20.83683861
80DYRK1B0.83248366
81PTK2B0.81650710
82SYK0.80614167
83CSNK1G10.80294780
84SGK30.79772846
85NTRK10.77921010
86CDK50.75629010
87TEC0.74817538
88PIK3CG0.74124994
89GRK10.73773269
90HIPK20.73163327
91HCK0.71104444
92TLK10.70776182
93KSR20.68606377
94OXSR10.68344068
95CAMKK20.68297716
96STK240.67435558
97BCR0.66350155
98BRAF0.65848414
99SIK20.65747665
100IKBKB0.65449717
101MAP3K70.65356426
102PIK3CA0.65055291
103PRKCQ0.64785495
104FLT30.64672298
105PDGFRA0.64474183
106STK380.63845112
107MST40.63653945
108CSF1R0.63587833
109PINK10.62323314
110RET0.61495633
111UHMK10.61222378
112SGK10.60556434
113AKT30.58944397
114MATK0.58771572
115MAP2K40.58300357
116MYLK0.57847146
117IRAK40.57841666
118LYN0.57186554
119MAP2K10.56386589
120PLK40.55974918
121PNCK0.55934588
122PRKD20.54879743
123TNIK0.53884781
124RPS6KA40.53863993
125GRK60.53114586
126GRK70.53074784
127PRKCZ0.52858103
128CAMK2B0.52599636
129PRKD10.51732383
130MARK20.51488707
131CDK190.51062410
132PKN10.50165493
133PRKAA10.50160386
134ILK0.48858065
135WNK30.48684881
136PRKCG0.48485853
137FRK0.48438846
138LIMK10.47653750
139ITK0.47619501
140LCK0.47441035
141STK390.46951484
142ZAP700.46927734
143BTK0.45822164
144ABL10.45544433
145JAK30.43434385
146DDR20.43241784
147MAP3K50.42596855
148CCNB10.42437456
149TAOK10.41967239
150MAP3K110.40766550
151CAMK1G0.40417568
152CAMK40.39537501
153MARK30.39181646
154TBK10.38834513
155PTK20.38407069
156TESK10.38135453
157IRAK10.37968909
158ROCK20.35980130
159CDK80.34293161
160CDK30.34099546
161PRKG10.34076243
162MAPK120.32253642

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.94369894
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.64577205
3Insulin secretion_Homo sapiens_hsa049112.48852937
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33377879
5Regulation of autophagy_Homo sapiens_hsa041402.18482999
6Dilated cardiomyopathy_Homo sapiens_hsa054142.15262653
7Circadian entrainment_Homo sapiens_hsa047132.06124185
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.98240604
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.93731172
10Allograft rejection_Homo sapiens_hsa053301.93104788
11Phototransduction_Homo sapiens_hsa047441.89702677
12Graft-versus-host disease_Homo sapiens_hsa053321.89113189
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88504413
14Olfactory transduction_Homo sapiens_hsa047401.87580181
15Circadian rhythm_Homo sapiens_hsa047101.87510922
16Amphetamine addiction_Homo sapiens_hsa050311.83979902
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81147460
18Cardiac muscle contraction_Homo sapiens_hsa042601.79835016
19Butanoate metabolism_Homo sapiens_hsa006501.77979184
20Long-term potentiation_Homo sapiens_hsa047201.76707621
21Autoimmune thyroid disease_Homo sapiens_hsa053201.76182331
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.72392310
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69670424
24Asthma_Homo sapiens_hsa053101.65528027
25Nicotine addiction_Homo sapiens_hsa050331.59964808
26Basal transcription factors_Homo sapiens_hsa030221.59290592
27Type II diabetes mellitus_Homo sapiens_hsa049301.56166959
28Synaptic vesicle cycle_Homo sapiens_hsa047211.54541321
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52198855
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51890735
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51740706
32Linoleic acid metabolism_Homo sapiens_hsa005911.51596777
33Type I diabetes mellitus_Homo sapiens_hsa049401.50908613
34Vibrio cholerae infection_Homo sapiens_hsa051101.49239804
35Dopaminergic synapse_Homo sapiens_hsa047281.49089010
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47654128
37Glutamatergic synapse_Homo sapiens_hsa047241.47297690
38Taste transduction_Homo sapiens_hsa047421.46933099
39Primary immunodeficiency_Homo sapiens_hsa053401.46562400
40Cocaine addiction_Homo sapiens_hsa050301.44877576
41Cholinergic synapse_Homo sapiens_hsa047251.44446448
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44071783
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.43933556
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.39508361
45Dorso-ventral axis formation_Homo sapiens_hsa043201.37611307
46Oxytocin signaling pathway_Homo sapiens_hsa049211.37579069
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35920210
48Renin secretion_Homo sapiens_hsa049241.35833668
49Morphine addiction_Homo sapiens_hsa050321.35199282
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33055799
51GABAergic synapse_Homo sapiens_hsa047271.32752789
52Serotonergic synapse_Homo sapiens_hsa047261.31783658
53GnRH signaling pathway_Homo sapiens_hsa049121.30170700
54Gastric acid secretion_Homo sapiens_hsa049711.29738690
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27165944
56Axon guidance_Homo sapiens_hsa043601.27046846
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.26296579
58Glucagon signaling pathway_Homo sapiens_hsa049221.23370234
59Calcium signaling pathway_Homo sapiens_hsa040201.22036713
60Rheumatoid arthritis_Homo sapiens_hsa053231.21309734
61Collecting duct acid secretion_Homo sapiens_hsa049661.20764364
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20497767
63Hematopoietic cell lineage_Homo sapiens_hsa046401.17990916
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16050321
65cAMP signaling pathway_Homo sapiens_hsa040241.14929604
66Peroxisome_Homo sapiens_hsa041461.14500339
67Staphylococcus aureus infection_Homo sapiens_hsa051501.12519740
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11701785
69Salivary secretion_Homo sapiens_hsa049701.10618523
70Melanogenesis_Homo sapiens_hsa049161.10340003
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10261683
72Gap junction_Homo sapiens_hsa045401.10150442
73Estrogen signaling pathway_Homo sapiens_hsa049151.09011099
74Ether lipid metabolism_Homo sapiens_hsa005651.07760570
75ABC transporters_Homo sapiens_hsa020101.05846268
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05247824
77Phagosome_Homo sapiens_hsa041451.02439841
78Long-term depression_Homo sapiens_hsa047301.01413567
79Nitrogen metabolism_Homo sapiens_hsa009101.00571547
80Protein export_Homo sapiens_hsa030600.99883605
81Chemical carcinogenesis_Homo sapiens_hsa052040.98420468
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.97201640
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.96796702
84Antigen processing and presentation_Homo sapiens_hsa046120.96417289
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95603752
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95189837
87Ovarian steroidogenesis_Homo sapiens_hsa049130.94254950
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93004811
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91931538
90Insulin signaling pathway_Homo sapiens_hsa049100.91464964
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.90788009
92Leishmaniasis_Homo sapiens_hsa051400.89576674
93Steroid biosynthesis_Homo sapiens_hsa001000.88199847
94Glioma_Homo sapiens_hsa052140.88028992
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87801777
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.87616989
97Endometrial cancer_Homo sapiens_hsa052130.87123260
98Wnt signaling pathway_Homo sapiens_hsa043100.86786213
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86566188
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86358017
101Tuberculosis_Homo sapiens_hsa051520.85814210
102ErbB signaling pathway_Homo sapiens_hsa040120.85102158
103Renal cell carcinoma_Homo sapiens_hsa052110.83804604
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81458721
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80279326
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79960606
107Hedgehog signaling pathway_Homo sapiens_hsa043400.79458004
108Hippo signaling pathway_Homo sapiens_hsa043900.79356728
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79292669
110Viral myocarditis_Homo sapiens_hsa054160.78464983
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77957021
112Legionellosis_Homo sapiens_hsa051340.76714479
113Tryptophan metabolism_Homo sapiens_hsa003800.76396287
114Tight junction_Homo sapiens_hsa045300.76257134
115Prolactin signaling pathway_Homo sapiens_hsa049170.75316675
116Alzheimers disease_Homo sapiens_hsa050100.73527066
117Thyroid hormone synthesis_Homo sapiens_hsa049180.72955048
118Arachidonic acid metabolism_Homo sapiens_hsa005900.72947048
119VEGF signaling pathway_Homo sapiens_hsa043700.71963515
120Adherens junction_Homo sapiens_hsa045200.70536973
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70290449
122Focal adhesion_Homo sapiens_hsa045100.70258503
123Insulin resistance_Homo sapiens_hsa049310.68838651
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68776501
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68089419
126Oxidative phosphorylation_Homo sapiens_hsa001900.68077200
127Pancreatic secretion_Homo sapiens_hsa049720.67832156
128MAPK signaling pathway_Homo sapiens_hsa040100.66951461
129Huntingtons disease_Homo sapiens_hsa050160.65882933
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62953262
131Osteoclast differentiation_Homo sapiens_hsa043800.62027171
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61709677
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60611507
134Basal cell carcinoma_Homo sapiens_hsa052170.59281047
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59152003
136Malaria_Homo sapiens_hsa051440.58294818
137Chemokine signaling pathway_Homo sapiens_hsa040620.57166933
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.57016072
139Salmonella infection_Homo sapiens_hsa051320.55851226
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55143358
141Ras signaling pathway_Homo sapiens_hsa040140.54725207
142Colorectal cancer_Homo sapiens_hsa052100.54647524
143Herpes simplex infection_Homo sapiens_hsa051680.54500124
144FoxO signaling pathway_Homo sapiens_hsa040680.53516895
145Retinol metabolism_Homo sapiens_hsa008300.53197772
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51709509
147AMPK signaling pathway_Homo sapiens_hsa041520.51587778
148Measles_Homo sapiens_hsa051620.50284507
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49729346
150Parkinsons disease_Homo sapiens_hsa050120.49516899
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48494092
152Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48409912
153Oocyte meiosis_Homo sapiens_hsa041140.48096551
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48037058
155Lysosome_Homo sapiens_hsa041420.47521565
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47444119
157Proteoglycans in cancer_Homo sapiens_hsa052050.45215521
158Sphingolipid metabolism_Homo sapiens_hsa006000.45176803
159Fanconi anemia pathway_Homo sapiens_hsa034600.45156044
160mTOR signaling pathway_Homo sapiens_hsa041500.45080262
161Melanoma_Homo sapiens_hsa052180.44868610
162Choline metabolism in cancer_Homo sapiens_hsa052310.44824508
163Rap1 signaling pathway_Homo sapiens_hsa040150.43913062
164Shigellosis_Homo sapiens_hsa051310.43771394
165African trypanosomiasis_Homo sapiens_hsa051430.43482712
166ECM-receptor interaction_Homo sapiens_hsa045120.42499483
167RNA polymerase_Homo sapiens_hsa030200.41986629
168Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41278108
169Phospholipase D signaling pathway_Homo sapiens_hsa040720.41166301
170T cell receptor signaling pathway_Homo sapiens_hsa046600.37515468
171TNF signaling pathway_Homo sapiens_hsa046680.34728321
172Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34517969
173Caffeine metabolism_Homo sapiens_hsa002320.32483412

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