DUSP19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.21822936
2central nervous system myelination (GO:0022010)9.21822936
3fatty acid elongation (GO:0030497)6.48382592
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.45828853
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.37310158
6ATP synthesis coupled proton transport (GO:0015986)5.22127403
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22127403
8protein neddylation (GO:0045116)5.07467541
9chaperone-mediated protein transport (GO:0072321)4.99161475
10behavioral response to nicotine (GO:0035095)4.97673430
11myelination (GO:0042552)4.93591328
12axon ensheathment (GO:0008366)4.84398181
13ensheathment of neurons (GO:0007272)4.84398181
14long-chain fatty acid biosynthetic process (GO:0042759)4.74187486
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.66125107
16respiratory electron transport chain (GO:0022904)4.58929841
17electron transport chain (GO:0022900)4.45786096
18negative regulation of protein localization to cell surface (GO:2000009)4.42331456
19cholesterol biosynthetic process (GO:0006695)4.40021243
20substantia nigra development (GO:0021762)4.35859151
21epithelial cilium movement (GO:0003351)4.35386491
22nucleotide transmembrane transport (GO:1901679)4.30379856
23negative regulation of neurotransmitter transport (GO:0051589)4.00337328
24piRNA metabolic process (GO:0034587)3.93896564
25oligodendrocyte differentiation (GO:0048709)3.88367349
26cilium movement (GO:0003341)3.87342521
27sterol biosynthetic process (GO:0016126)3.84562626
28response to redox state (GO:0051775)3.81914834
29GPI anchor biosynthetic process (GO:0006506)3.73859171
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.73122878
31presynaptic membrane assembly (GO:0097105)3.72934265
32mannosylation (GO:0097502)3.69589020
33cilium or flagellum-dependent cell motility (GO:0001539)3.68428357
34signal peptide processing (GO:0006465)3.67432406
35negative regulation of neurotransmitter secretion (GO:0046929)3.66194125
36regulation of collateral sprouting (GO:0048670)3.64187011
37presynaptic membrane organization (GO:0097090)3.62564826
38L-fucose catabolic process (GO:0042355)3.58720093
39fucose catabolic process (GO:0019317)3.58720093
40L-fucose metabolic process (GO:0042354)3.58720093
41protein complex biogenesis (GO:0070271)3.55131122
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.50358883
43NADH dehydrogenase complex assembly (GO:0010257)3.50358883
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50358883
45multicellular organism reproduction (GO:0032504)3.42921987
46response to pheromone (GO:0019236)3.39019290
47cellular ketone body metabolic process (GO:0046950)3.38068433
48axoneme assembly (GO:0035082)3.34710000
49GPI anchor metabolic process (GO:0006505)3.33386740
50amino acid salvage (GO:0043102)3.32799077
51L-methionine salvage (GO:0071267)3.32799077
52L-methionine biosynthetic process (GO:0071265)3.32799077
53protein localization to cilium (GO:0061512)3.32000424
54neuron cell-cell adhesion (GO:0007158)3.30459196
55preassembly of GPI anchor in ER membrane (GO:0016254)3.28607333
56axonemal dynein complex assembly (GO:0070286)3.22587580
57cilium organization (GO:0044782)3.21287347
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.21030427
59termination of RNA polymerase III transcription (GO:0006386)3.21030427
60DNA methylation involved in gamete generation (GO:0043046)3.20798716
61synapsis (GO:0007129)3.20053075
62positive regulation of oligodendrocyte differentiation (GO:0048714)3.19849669
63ribosomal small subunit biogenesis (GO:0042274)3.19704923
64negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.19168525
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18441845
66protein polyglutamylation (GO:0018095)3.17621337
67amyloid precursor protein metabolic process (GO:0042982)3.17502059
68long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.15226740
69regulation of cilium movement (GO:0003352)3.14367864
70peptidyl-histidine modification (GO:0018202)3.13442676
71myelin maintenance (GO:0043217)3.12650557
72cilium assembly (GO:0042384)3.12343621
73regulation of hexokinase activity (GO:1903299)3.11858762
74regulation of glucokinase activity (GO:0033131)3.11858762
75mitochondrial respiratory chain complex assembly (GO:0033108)3.11315839
76regulation of dopamine metabolic process (GO:0042053)3.10617908
77regulation of catecholamine metabolic process (GO:0042069)3.10617908
78cilium morphogenesis (GO:0060271)3.09171219
79indolalkylamine metabolic process (GO:0006586)3.08599265
80nonmotile primary cilium assembly (GO:0035058)3.08181507
81regulation of meiosis I (GO:0060631)3.06924392
82centriole replication (GO:0007099)3.05848648
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.05129923
84ketone body metabolic process (GO:1902224)3.05097393
85respiratory chain complex IV assembly (GO:0008535)3.03792085
86negative regulation of execution phase of apoptosis (GO:1900118)3.00296500
87platelet dense granule organization (GO:0060155)3.00144735
88indole-containing compound catabolic process (GO:0042436)2.99898690
89indolalkylamine catabolic process (GO:0046218)2.99898690
90tryptophan catabolic process (GO:0006569)2.99898690
91isoprenoid biosynthetic process (GO:0008299)2.98787042
92protein palmitoylation (GO:0018345)2.97806434
93retinal cone cell development (GO:0046549)2.97612439
94long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.97110911
95gamma-aminobutyric acid transport (GO:0015812)2.93911035
96nucleotide transport (GO:0006862)2.91221913
97water-soluble vitamin biosynthetic process (GO:0042364)2.89535233
98regulation of mitochondrial translation (GO:0070129)2.88797656
99protein targeting to mitochondrion (GO:0006626)2.87137590
100protein K11-linked deubiquitination (GO:0035871)2.84124456
101neuronal action potential (GO:0019228)2.83317369
102photoreceptor cell maintenance (GO:0045494)2.82832231
103hydrogen ion transmembrane transport (GO:1902600)2.82623743
104glycerophospholipid catabolic process (GO:0046475)2.81579094
105male meiosis (GO:0007140)2.80985024
106response to methylmercury (GO:0051597)2.80021473
107cullin deneddylation (GO:0010388)2.78234632
108neural nucleus development (GO:0048857)2.78143394
109proton transport (GO:0015992)2.77527017
110detection of light stimulus involved in sensory perception (GO:0050962)2.77066531
111detection of light stimulus involved in visual perception (GO:0050908)2.77066531
112kidney morphogenesis (GO:0060993)2.76954666
113proteasome assembly (GO:0043248)2.76315712
114regulation of feeding behavior (GO:0060259)2.75437555
115dopamine transport (GO:0015872)2.74889410
1167-methylguanosine mRNA capping (GO:0006370)2.74731229
1177-methylguanosine RNA capping (GO:0009452)2.74131149
118RNA capping (GO:0036260)2.74131149
119magnesium ion transport (GO:0015693)2.73440943
120microtubule polymerization or depolymerization (GO:0031109)2.73386453
121reflex (GO:0060004)2.70430768
122neuron fate determination (GO:0048664)2.70074461
123photoreceptor cell differentiation (GO:0046530)2.69899658
124eye photoreceptor cell differentiation (GO:0001754)2.69899658
125hydrogen transport (GO:0006818)2.69772508
126regulation of action potential (GO:0098900)2.69249778
127* negative regulation of JUN kinase activity (GO:0043508)2.69067348
128sulfation (GO:0051923)2.67362725
129positive regulation of meiosis (GO:0045836)2.66961147
130creatine metabolic process (GO:0006600)2.66026583
131protein deneddylation (GO:0000338)2.64768929
132establishment of mitochondrion localization (GO:0051654)2.64019684
133cerebral cortex radially oriented cell migration (GO:0021799)2.62618531
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61610654
135peptidyl-cysteine modification (GO:0018198)2.60743698
136establishment of protein localization to mitochondrion (GO:0072655)2.60475592
137fatty-acyl-CoA biosynthetic process (GO:0046949)2.60444383
138sperm motility (GO:0030317)2.60378960
139peripheral nervous system axon ensheathment (GO:0032292)2.60315191
140myelination in peripheral nervous system (GO:0022011)2.60315191
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59494922
142negative regulation of ligase activity (GO:0051352)2.59494922
143polyol catabolic process (GO:0046174)2.58665416
144negative regulation of telomere maintenance (GO:0032205)2.58115512
145oxidative demethylation (GO:0070989)2.58092701
146cellular response to epinephrine stimulus (GO:0071872)2.57461476
147deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.57285970
148amine catabolic process (GO:0009310)2.56475375
149cellular biogenic amine catabolic process (GO:0042402)2.56475375
150neurotransmitter uptake (GO:0001504)2.55780763
151primary amino compound metabolic process (GO:1901160)2.55141373
152behavioral response to ethanol (GO:0048149)2.54843790
153intraciliary transport (GO:0042073)2.53241132
154fatty-acyl-CoA metabolic process (GO:0035337)2.53203865
155transmission of nerve impulse (GO:0019226)2.51998954
156cellular component assembly involved in morphogenesis (GO:0010927)2.51909902
157tryptophan metabolic process (GO:0006568)2.51591168
158indole-containing compound metabolic process (GO:0042430)2.51407678
159regulation of acrosome reaction (GO:0060046)2.51059270
160neuronal action potential propagation (GO:0019227)2.50843055
161protein import into peroxisome matrix (GO:0016558)2.50825519
162inositol phosphate catabolic process (GO:0071545)2.49994296
163protein localization to mitochondrion (GO:0070585)2.49015071
164negative regulation of axonogenesis (GO:0050771)2.48990828
165nephron tubule morphogenesis (GO:0072078)2.48891565
166nephron epithelium morphogenesis (GO:0072088)2.48891565
167serotonin metabolic process (GO:0042428)2.48263379
168positive regulation of meiotic cell cycle (GO:0051446)2.48117669
169DNA deamination (GO:0045006)2.47915130
170replication fork processing (GO:0031297)2.47447155
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46409023
172negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46290814
173cotranslational protein targeting to membrane (GO:0006613)2.46120073
174kynurenine metabolic process (GO:0070189)2.44865256
175DNA double-strand break processing (GO:0000729)2.44790777
176male meiosis I (GO:0007141)2.44706792
177rhodopsin mediated signaling pathway (GO:0016056)2.42715694
178acrosome reaction (GO:0007340)2.40831347
179regulation of microtubule-based movement (GO:0060632)2.40374731
180regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40217699
181somite rostral/caudal axis specification (GO:0032525)2.38419689
182negative regulation of DNA-dependent DNA replication (GO:2000104)2.37863524
183smoothened signaling pathway (GO:0007224)2.36623032
184meiotic cell cycle (GO:0051321)2.35459706
185cellular response to ATP (GO:0071318)2.33818772
186reciprocal meiotic recombination (GO:0007131)2.30336054
187reciprocal DNA recombination (GO:0035825)2.30336054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.59402845
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.02716202
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75774703
4ZNF274_21170338_ChIP-Seq_K562_Hela3.21737530
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.17380769
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09168977
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09037991
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98085221
9GBX2_23144817_ChIP-Seq_PC3_Human2.88461600
10PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.87576336
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.69728697
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61523635
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59684766
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58257914
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55833156
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44404433
17* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.27371210
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.22123303
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18596993
20TAF15_26573619_Chip-Seq_HEK293_Human2.07832769
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07335312
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89288676
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89288287
24FUS_26573619_Chip-Seq_HEK293_Human1.88936307
25ER_23166858_ChIP-Seq_MCF-7_Human1.85911036
26EZH2_22144423_ChIP-Seq_EOC_Human1.82325063
27AR_21572438_ChIP-Seq_LNCaP_Human1.81818382
28* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79978835
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.78954005
30VDR_22108803_ChIP-Seq_LS180_Human1.75837442
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73041455
32SMAD4_21799915_ChIP-Seq_A2780_Human1.72152814
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.71554257
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67423058
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66462758
36* STAT3_23295773_ChIP-Seq_U87_Human1.64690877
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64503496
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.64290208
39IRF1_19129219_ChIP-ChIP_H3396_Human1.64198503
40BCAT_22108803_ChIP-Seq_LS180_Human1.62324994
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60755213
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55181767
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52626981
44AR_25329375_ChIP-Seq_VCAP_Human1.52288035
45CBP_20019798_ChIP-Seq_JUKART_Human1.51219380
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51219380
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49981667
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49393167
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49335327
50TCF4_23295773_ChIP-Seq_U87_Human1.48788549
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45225037
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43378413
53ELK1_19687146_ChIP-ChIP_HELA_Human1.41106816
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40813932
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.40590489
56TCF4_22108803_ChIP-Seq_LS180_Human1.39969799
57VDR_23849224_ChIP-Seq_CD4+_Human1.39719272
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37756375
59SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.36656982
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36357374
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36123855
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34687324
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.33259602
64P300_19829295_ChIP-Seq_ESCs_Human1.32713367
65TP53_22573176_ChIP-Seq_HFKS_Human1.32488185
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.31241646
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30686074
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30686074
69EWS_26573619_Chip-Seq_HEK293_Human1.30392841
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29096016
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28567313
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26371613
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.25988149
74RUNX2_22187159_ChIP-Seq_PCA_Human1.25490399
75EOMES_21245162_ChIP-Seq_HESCs_Human1.25307253
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25278117
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23947736
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.23752811
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.22649494
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22623810
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.22242204
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22242204
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22125265
84DCP1A_22483619_ChIP-Seq_HELA_Human1.22034018
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.21092043
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.18979948
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18821625
88CDX2_22108803_ChIP-Seq_LS180_Human1.18302624
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18126485
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18111756
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17308080
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.17205569
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.15838355
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14240726
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13495997
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12860528
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12593358
98MYC_18940864_ChIP-ChIP_HL60_Human1.12413505
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.12076156
100SOX17_20123909_ChIP-Seq_XEN_Mouse1.11383967
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10363039
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10301376
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10291669
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.09691240
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.08778936
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.08068506
107NANOG_19829295_ChIP-Seq_ESCs_Human1.07593801
108SOX2_19829295_ChIP-Seq_ESCs_Human1.07593801
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06774465
110HTT_18923047_ChIP-ChIP_STHdh_Human1.06157023
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.05452029
112SOX9_26525672_Chip-Seq_HEART_Mouse1.05104021
113NCOR_22424771_ChIP-Seq_293T_Human1.04387109
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.03915301
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03859910
116P300_18555785_Chip-Seq_ESCs_Mouse1.02810480
117AR_20517297_ChIP-Seq_VCAP_Human1.02570997
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.02215282
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00942807
120TBL1_22424771_ChIP-Seq_293T_Human1.00726996
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00592893
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00288893
123P53_22387025_ChIP-Seq_ESCs_Mouse0.99494697
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99397675
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99154502
126REST_21632747_ChIP-Seq_MESCs_Mouse0.98256036
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98134543
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97836488
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97469541
130STAT3_18555785_Chip-Seq_ESCs_Mouse0.97320158
131CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96855435
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96554711
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96528100
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.95680742
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95594783
136REST_18959480_ChIP-ChIP_MESCs_Mouse0.95243130
137SOX2_18555785_Chip-Seq_ESCs_Mouse0.94642664
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93434208
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93327455
140SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92366681
141FOXP3_21729870_ChIP-Seq_TREG_Human0.92208936
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.92042734
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91727067
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91334542
145IGF1R_20145208_ChIP-Seq_DFB_Human0.91190427
146EED_16625203_ChIP-ChIP_MESCs_Mouse0.90297903
147RNF2_27304074_Chip-Seq_NSC_Mouse0.90153795
148* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90004929
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89665091
150FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89263001
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88722135
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.87255038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.39009663
2MP0005171_absent_coat_pigmentation4.27748782
3MP0003136_yellow_coat_color3.92863931
4MP0000920_abnormal_myelination3.91897836
5MP0001529_abnormal_vocalization3.72797759
6MP0000569_abnormal_digit_pigmentation3.26232783
7MP0001905_abnormal_dopamine_level2.78297298
8MP0004270_analgesia2.77886611
9MP0002837_dystrophic_cardiac_calcinosis2.53467877
10MP0002102_abnormal_ear_morphology2.41887680
11MP0002272_abnormal_nervous_system2.28439387
12MP0003787_abnormal_imprinting2.28281482
13MP0001486_abnormal_startle_reflex2.22444908
14MP0001485_abnormal_pinna_reflex2.13586799
15MP0005408_hypopigmentation2.11888203
16MP0004742_abnormal_vestibular_system2.11829002
17MP0003329_amyloid_beta_deposits2.09428252
18MP0004859_abnormal_synaptic_plasticity2.06731775
19MP0002064_seizures2.05124978
20MP0005410_abnormal_fertilization2.03328917
21MP0002653_abnormal_ependyma_morphology2.01229127
22MP0004381_abnormal_hair_follicle1.99793856
23MP0005084_abnormal_gallbladder_morpholo1.99744637
24MP0002638_abnormal_pupillary_reflex1.98808013
25MP0004043_abnormal_pH_regulation1.97915886
26MP0003806_abnormal_nucleotide_metabolis1.87988190
27MP0003950_abnormal_plasma_membrane1.85732404
28MP0009379_abnormal_foot_pigmentation1.82585318
29MP0000778_abnormal_nervous_system1.78242907
30MP0003635_abnormal_synaptic_transmissio1.74910044
31MP0004142_abnormal_muscle_tone1.72461259
32MP0008875_abnormal_xenobiotic_pharmacok1.68989215
33MP0009780_abnormal_chondrocyte_physiolo1.67407264
34MP0009745_abnormal_behavioral_response1.66348744
35MP0008872_abnormal_physiological_respon1.64681510
36MP0000427_abnormal_hair_cycle1.64022339
37MP0004147_increased_porphyrin_level1.62216200
38MP0003634_abnormal_glial_cell1.61460728
39MP0002572_abnormal_emotion/affect_behav1.58305426
40MP0005409_darkened_coat_color1.58238209
41MP0002938_white_spotting1.57868744
42MP0009046_muscle_twitch1.56548852
43MP0005423_abnormal_somatic_nervous1.55433792
44MP0004885_abnormal_endolymph1.54963902
45MP0002734_abnormal_mechanical_nocicepti1.52619034
46MP0003632_abnormal_nervous_system1.51651361
47MP0003690_abnormal_glial_cell1.50229879
48MP0002876_abnormal_thyroid_physiology1.49936981
49MP0003890_abnormal_embryonic-extraembry1.45243452
50MP0004215_abnormal_myocardial_fiber1.45210646
51MP0002928_abnormal_bile_duct1.45001852
52MP0006292_abnormal_olfactory_placode1.43847234
53MP0002160_abnormal_reproductive_system1.40274469
54MP0004133_heterotaxia1.39354885
55MP0002063_abnormal_learning/memory/cond1.38372239
56MP0002735_abnormal_chemical_nociception1.34898188
57MP0001968_abnormal_touch/_nociception1.33765634
58MP0002229_neurodegeneration1.33711618
59MP0002736_abnormal_nociception_after1.33682831
60MP0008877_abnormal_DNA_methylation1.26172196
61MP0001440_abnormal_grooming_behavior1.25922373
62MP0004924_abnormal_behavior1.25121471
63MP0005386_behavior/neurological_phenoty1.25121471
64MP0003283_abnormal_digestive_organ1.23053223
65MP0002138_abnormal_hepatobiliary_system1.19212458
66MP0000372_irregular_coat_pigmentation1.19147252
67MP0005379_endocrine/exocrine_gland_phen1.18747612
68MP0002557_abnormal_social/conspecific_i1.17691616
69MP0005551_abnormal_eye_electrophysiolog1.17528607
70MP0003698_abnormal_male_reproductive1.17145471
71MP0008775_abnormal_heart_ventricle1.16624761
72MP0001346_abnormal_lacrimal_gland1.16569037
73MP0001929_abnormal_gametogenesis1.15263056
74MP0005085_abnormal_gallbladder_physiolo1.13335570
75MP0001501_abnormal_sleep_pattern1.12943375
76MP0003195_calcinosis1.11807133
77MP0003938_abnormal_ear_development1.11391038
78MP0001970_abnormal_pain_threshold1.11267776
79MP0005389_reproductive_system_phenotype1.09316619
80MP0002882_abnormal_neuron_morphology1.08913501
81MP0003121_genomic_imprinting1.08641548
82MP0003646_muscle_fatigue1.08590424
83MP0002163_abnormal_gland_morphology1.07538772
84MP0001188_hyperpigmentation1.07527763
85MP0000015_abnormal_ear_pigmentation1.07337574
86MP0008058_abnormal_DNA_repair1.06725368
87MP0005187_abnormal_penis_morphology1.06591436
88MP0005451_abnormal_body_composition1.06229354
89MP0002066_abnormal_motor_capabilities/c1.05258321
90MP0005075_abnormal_melanosome_morpholog1.05088373
91MP0004084_abnormal_cardiac_muscle1.05062126
92MP0001963_abnormal_hearing_physiology1.04858378
93MP0000631_abnormal_neuroendocrine_gland1.04687016
94MP0008569_lethality_at_weaning1.04270168
95MP0003631_nervous_system_phenotype1.03789932
96MP0000230_abnormal_systemic_arterial1.03186642
97MP0003718_maternal_effect1.03004899
98MP0010386_abnormal_urinary_bladder1.02766507
99MP0006276_abnormal_autonomic_nervous1.00965243
100MP0002234_abnormal_pharynx_morphology1.00960486
101MP0000955_abnormal_spinal_cord1.00827885
102MP0002822_catalepsy0.99503158
103MP0000462_abnormal_digestive_system0.99416711
104MP0004134_abnormal_chest_morphology0.98847649
105MP0002067_abnormal_sensory_capabilities0.97427364
106MP0001299_abnormal_eye_distance/0.96709579
107MP0003011_delayed_dark_adaptation0.96517338
108MP0001661_extended_life_span0.96273772
109MP0004145_abnormal_muscle_electrophysio0.96148889
110MP0008932_abnormal_embryonic_tissue0.93403215
111MP0002752_abnormal_somatic_nervous0.92649368
112MP0008789_abnormal_olfactory_epithelium0.92629100
113MP0005195_abnormal_posterior_eye0.91611998
114MP0004085_abnormal_heartbeat0.91022976
115MP0002210_abnormal_sex_determination0.90082617
116MP0002751_abnormal_autonomic_nervous0.90038550
117MP0002277_abnormal_respiratory_mucosa0.90018489
118MP0006072_abnormal_retinal_apoptosis0.88839986
119MP0000383_abnormal_hair_follicle0.88728089
120MP0001944_abnormal_pancreas_morphology0.86898795
121MP0009250_abnormal_appendicular_skeleto0.85817134
122MP0005646_abnormal_pituitary_gland0.85813963
123MP0005253_abnormal_eye_physiology0.84943535
124MP0003252_abnormal_bile_duct0.84823834
125MP0009697_abnormal_copulation0.84781896
126MP0003119_abnormal_digestive_system0.84448867
127MP0005623_abnormal_meninges_morphology0.83553662
128MP0005365_abnormal_bile_salt0.83207461
129MP0000013_abnormal_adipose_tissue0.83161745
130MP0000026_abnormal_inner_ear0.81584195
131MP0000653_abnormal_sex_gland0.81206035
132MP0005174_abnormal_tail_pigmentation0.80788303
133MP0002693_abnormal_pancreas_physiology0.80252658
134MP0002095_abnormal_skin_pigmentation0.79995239
135MP0001984_abnormal_olfaction0.79689420
136MP0002733_abnormal_thermal_nociception0.79238291
137MP0002152_abnormal_brain_morphology0.78191070
138MP0001502_abnormal_circadian_rhythm0.77539315
139MP0000647_abnormal_sebaceous_gland0.77440264
140MP0001727_abnormal_embryo_implantation0.76868869
141MP0000604_amyloidosis0.76511441
142MP0003937_abnormal_limbs/digits/tail_de0.76199782
143MP0000537_abnormal_urethra_morphology0.75957083
144MP0006036_abnormal_mitochondrial_physio0.74940414
145MP0000762_abnormal_tongue_morphology0.74307298
146MP0002184_abnormal_innervation0.73637955
147MP0005645_abnormal_hypothalamus_physiol0.73321073
148MP0001542_abnormal_bone_strength0.72352897
149MP0008057_abnormal_DNA_replication0.72306557
150MP0001986_abnormal_taste_sensitivity0.72026973
151MP0001348_abnormal_lacrimal_gland0.69852832
152MP0000613_abnormal_salivary_gland0.69548115
153MP0003172_abnormal_lysosome_physiology0.68120474

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)5.23768234
2Pancreatic cysts (HP:0001737)4.68430621
3Acute necrotizing encephalopathy (HP:0006965)4.63910106
4Increased hepatocellular lipid droplets (HP:0006565)4.60164899
5Sensory axonal neuropathy (HP:0003390)4.53317865
6Mitochondrial inheritance (HP:0001427)4.42952041
7Renal Fanconi syndrome (HP:0001994)4.42395394
8Pancreatic fibrosis (HP:0100732)4.34363215
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.32941206
10Hepatocellular necrosis (HP:0001404)4.21778020
11True hermaphroditism (HP:0010459)4.17840634
12Abnormality of midbrain morphology (HP:0002418)4.17436139
13Molar tooth sign on MRI (HP:0002419)4.17436139
14Abnormal mitochondria in muscle tissue (HP:0008316)4.10283874
15Lipid accumulation in hepatocytes (HP:0006561)4.07830367
16Increased serum pyruvate (HP:0003542)4.03625238
17Abnormality of glycolysis (HP:0004366)4.03625238
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.02069622
19Degeneration of the lateral corticospinal tracts (HP:0002314)4.02069622
20Leukodystrophy (HP:0002415)3.94451294
21Progressive macrocephaly (HP:0004481)3.84806972
22Acute encephalopathy (HP:0006846)3.84428326
23Nephronophthisis (HP:0000090)3.77194089
24Increased CSF lactate (HP:0002490)3.76507697
25Hepatic necrosis (HP:0002605)3.65736609
26Parakeratosis (HP:0001036)3.59270471
27Neurofibrillary tangles (HP:0002185)3.48710297
28Abnormality of the renal cortex (HP:0011035)3.47236871
29Neuroendocrine neoplasm (HP:0100634)3.39966251
30Pheochromocytoma (HP:0002666)3.30327160
31Abnormality of the renal medulla (HP:0100957)3.24009084
32Abnormal ciliary motility (HP:0012262)3.18411565
33Congenital stationary night blindness (HP:0007642)3.18345805
34Spastic paraparesis (HP:0002313)3.15672566
35Peripheral hypomyelination (HP:0007182)3.10360829
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.08589070
37CNS hypomyelination (HP:0003429)3.05664918
38Congenital ichthyosiform erythroderma (HP:0007431)3.01696700
39Abnormal auditory evoked potentials (HP:0006958)3.01337347
40Increased intramyocellular lipid droplets (HP:0012240)3.00356243
41Exertional dyspnea (HP:0002875)2.95583931
42Abnormal respiratory motile cilium morphology (HP:0005938)2.91663707
43Abnormal respiratory epithelium morphology (HP:0012253)2.91663707
44Alacrima (HP:0000522)2.89739330
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89547231
46Chronic hepatic failure (HP:0100626)2.88674029
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82985843
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82985843
49Respiratory failure (HP:0002878)2.82287233
50Tubular atrophy (HP:0000092)2.81934957
51Cystic liver disease (HP:0006706)2.80039854
52Type II lissencephaly (HP:0007260)2.75205786
53Abnormality of renal resorption (HP:0011038)2.69641009
54Renal cortical cysts (HP:0000803)2.69274327
55Decreased lacrimation (HP:0000633)2.63831467
56Attenuation of retinal blood vessels (HP:0007843)2.61896444
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61869133
58Hypothermia (HP:0002045)2.57156364
59Hyperventilation (HP:0002883)2.56078735
60Abnormal drinking behavior (HP:0030082)2.53493366
61Polydipsia (HP:0001959)2.53493366
62Large for gestational age (HP:0001520)2.52608844
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.48190650
64Furrowed tongue (HP:0000221)2.48136460
65Retinal dysplasia (HP:0007973)2.47339793
66Increased serum lactate (HP:0002151)2.45278684
67Abnormality of the corticospinal tract (HP:0002492)2.44573593
68Morphological abnormality of the inner ear (HP:0011390)2.43593383
69Increased muscle lipid content (HP:0009058)2.42122034
70Male pseudohermaphroditism (HP:0000037)2.39752799
71Respiratory difficulties (HP:0002880)2.38102381
72Hemiparesis (HP:0001269)2.37923089
73Gaze-evoked nystagmus (HP:0000640)2.36034035
74Abnormal rod and cone electroretinograms (HP:0008323)2.35219267
753-Methylglutaconic aciduria (HP:0003535)2.33410770
76Sclerocornea (HP:0000647)2.33147068
77Exercise intolerance (HP:0003546)2.31879368
78Cerebral edema (HP:0002181)2.30960504
79Abolished electroretinogram (ERG) (HP:0000550)2.29232824
80Hyperphosphaturia (HP:0003109)2.28581984
81Progressive inability to walk (HP:0002505)2.28266718
82Decreased central vision (HP:0007663)2.27229132
83White forelock (HP:0002211)2.27201414
84Inability to walk (HP:0002540)2.26852704
85CNS demyelination (HP:0007305)2.25948965
86Patchy hypopigmentation of hair (HP:0011365)2.25180248
87Optic disc pallor (HP:0000543)2.24654540
88Congenital hepatic fibrosis (HP:0002612)2.23839065
89Rhinitis (HP:0012384)2.23248921
90Lactic acidosis (HP:0003128)2.23155006
91Febrile seizures (HP:0002373)2.21657074
92Cerebral inclusion bodies (HP:0100314)2.21651347
93Pendular nystagmus (HP:0012043)2.20876238
94Erythroderma (HP:0001019)2.19226773
95Hypoplastic pelvis (HP:0008839)2.19150548
96Anencephaly (HP:0002323)2.15276775
97Nephrogenic diabetes insipidus (HP:0009806)2.11733163
98Abnormal urine phosphate concentration (HP:0012599)2.11611205
99Glycosuria (HP:0003076)2.11349241
100Abnormality of urine glucose concentration (HP:0011016)2.11349241
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10871739
102Abnormality of alanine metabolism (HP:0010916)2.10871739
103Hyperalaninemia (HP:0003348)2.10871739
104Abnormal biliary tract physiology (HP:0012439)2.10534169
105Bile duct proliferation (HP:0001408)2.10534169
106Megalencephaly (HP:0001355)2.08992830
107Progressive cerebellar ataxia (HP:0002073)2.06771803
108Cerebral hemorrhage (HP:0001342)2.06747625
109X-linked dominant inheritance (HP:0001423)2.06053273
110Spastic gait (HP:0002064)1.99914023
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.99787074
112Emotional lability (HP:0000712)1.99663638
113Myokymia (HP:0002411)1.99188035
114Cerebellar dysplasia (HP:0007033)1.99098395
115Medial flaring of the eyebrow (HP:0010747)1.98392088
116Optic nerve hypoplasia (HP:0000609)1.98098748
117Fair hair (HP:0002286)1.96988810
118Dynein arm defect of respiratory motile cilia (HP:0012255)1.96553532
119Absent/shortened dynein arms (HP:0200106)1.96553532
120Abnormality of the pons (HP:0007361)1.96467345
121Abnormality of the heme biosynthetic pathway (HP:0010472)1.96227351
122Keratoconus (HP:0000563)1.96204631
123Increased corneal curvature (HP:0100692)1.96204631
124Supernumerary spleens (HP:0009799)1.94684144
125Conical tooth (HP:0000698)1.93671813
126Methylmalonic acidemia (HP:0002912)1.93666563
127Postaxial foot polydactyly (HP:0001830)1.92702171
128Brushfield spots (HP:0001088)1.92627237
129Poor coordination (HP:0002370)1.92265165
130Polyuria (HP:0000103)1.91686784
131Congenital, generalized hypertrichosis (HP:0004540)1.91486688
132Protruding tongue (HP:0010808)1.91431796
133Lissencephaly (HP:0001339)1.89912901
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.89570366
135Proximal tubulopathy (HP:0000114)1.88557238
136Congenital sensorineural hearing impairment (HP:0008527)1.88391341
137Hypoplasia of the fovea (HP:0007750)1.86759142
138Aplasia/Hypoplasia of the fovea (HP:0008060)1.86759142
139Epileptic encephalopathy (HP:0200134)1.86307717
140Vaginal atresia (HP:0000148)1.86215468
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86132190
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86103593
143Intestinal atresia (HP:0011100)1.85838137
144Delusions (HP:0000746)1.85440514
145Focal motor seizures (HP:0011153)1.85028139
146Disproportionate short-trunk short stature (HP:0003521)1.84980141
147Abnormality of the labia minora (HP:0012880)1.84592248
148Hypoplasia of the pons (HP:0012110)1.84556766
149Broad-based gait (HP:0002136)1.84386037
150Adrenal hypoplasia (HP:0000835)1.83868037
151Severe muscular hypotonia (HP:0006829)1.83553864
152Occipital encephalocele (HP:0002085)1.82688802
153Akinesia (HP:0002304)1.81402456
154Oligodactyly (hands) (HP:0001180)1.79979584
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79887542
156Postaxial hand polydactyly (HP:0001162)1.79379322
157Hepatosplenomegaly (HP:0001433)1.79269567
158Methylmalonic aciduria (HP:0012120)1.78670292
159Genital tract atresia (HP:0001827)1.77609304
160Gastrointestinal atresia (HP:0002589)1.77405696
161Gait imbalance (HP:0002141)1.76065020
162Paraparesis (HP:0002385)1.74347848
163Supranuclear gaze palsy (HP:0000605)1.73962785
164Split foot (HP:0001839)1.72852819
165Abnormal respiratory motile cilium physiology (HP:0012261)1.72285971
166Cupped ear (HP:0000378)1.72023828
167Thickened helices (HP:0000391)1.70755303
168Blue irides (HP:0000635)1.70704541
169Abnormality of the phalanges of the 2nd finger (HP:0009541)1.70332539
170Genetic anticipation (HP:0003743)1.69465801
171Abnormality of the fovea (HP:0000493)1.68885222
172Ketoacidosis (HP:0001993)1.67309103
173Abnormality of DNA repair (HP:0003254)1.67047691
174Toxemia of pregnancy (HP:0100603)1.64919674
175Congenital primary aphakia (HP:0007707)1.63861129
176Delayed myelination (HP:0012448)1.60986554
177Abnormality of the septum pellucidum (HP:0007375)1.60598810
178Slow saccadic eye movements (HP:0000514)1.57781020
179Absent septum pellucidum (HP:0001331)1.57167325
180Delayed epiphyseal ossification (HP:0002663)1.56407998
181Aplasia of the phalanges of the hand (HP:0009802)1.55316723
182Aplasia involving bones of the extremities (HP:0009825)1.55316723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.58043401
2STK394.75884194
3PBK3.73794209
4CASK3.43249376
5OXSR13.29887712
6ADRBK22.80844472
7PINK12.79127860
8BCR2.70970152
9BMPR1B2.50298341
10ZAK2.46088073
11MAP4K22.41431988
12ACVR1B2.40301220
13BUB12.28077251
14GRK12.24714145
15WNK42.16284290
16MAPKAPK52.02447295
17TRIM281.98922057
18STK161.98416802
19MET1.97590693
20CDK191.95570542
21TESK21.95270161
22NTRK11.86843785
23LIMK11.81047816
24ARAF1.66955517
25UHMK11.63361507
26TLK11.57049957
27NEK61.51562961
28DAPK21.51367046
29CAMKK21.49695405
30PKN11.49405564
31CAMK2B1.45660140
32EPHA41.45429841
33STK31.44635658
34EPHB11.39912681
35PNCK1.37843719
36MKNK21.37419031
37STK38L1.36773756
38MARK11.35134916
39CSNK1G31.30873914
40TNIK1.27749417
41TAOK31.26716650
42MST41.16538571
43DYRK21.16185644
44ERBB31.13732452
45MUSK1.13387326
46NME11.12453178
47PAK31.11933743
48TIE11.08062747
49TSSK61.06469148
50PLK21.06464532
51MAPK151.06431329
52EIF2AK11.06288801
53CSNK1G11.03706576
54CSNK1A1L1.03669560
55EIF2AK31.00215035
56CCNB10.99669869
57WNK10.98805969
58SGK4940.97865446
59SGK2230.97865446
60CAMK2D0.97017036
61CDK140.95917485
62BRAF0.93527540
63ROCK20.93365970
64ADRBK10.92719980
65CAMK2A0.92082662
66IRAK10.92013258
67TGFBR10.90623852
68PLK30.89589041
69NTRK30.89296938
70STK240.88181327
71MAP2K70.87198501
72CLK10.86630581
73MAPKAPK30.85636971
74CSNK1G20.85088325
75BRSK20.84540432
76CAMK2G0.83542849
77SRPK10.83207390
78ABL20.82788756
79PDK30.80648700
80PDK40.80648700
81CDK150.79904291
82INSRR0.79397798
83CDK180.79347335
84OBSCN0.78162745
85MAPK130.78035129
86TXK0.75211009
87PRKCQ0.75107205
88PDK20.74462946
89PIK3CG0.73743505
90AKT30.72736255
91FGR0.72642687
92VRK10.72260699
93CDK11A0.72014608
94BMPR20.69239480
95CDK50.68817959
96PRKCE0.66786267
97NEK90.64272111
98WEE10.62994281
99PAK10.62904752
100NTRK20.61675974
101CHEK20.58953176
102NLK0.56686880
103CDK30.55913645
104MAP3K40.55625707
105TRPM70.54793509
106RPS6KA50.53617243
107FGFR20.52908408
108PHKG20.52635010
109PHKG10.52635010
110PLK40.51625164
111CSNK1A10.50736678
112TEC0.50121114
113NEK20.49929219
114MKNK10.49141247
115AURKA0.48137416
116WNK30.47329814
117CAMK10.47284214
118CDK80.46849707
119NUAK10.45927420
120MAP2K60.44038250
121ITK0.43763527
122PRPF4B0.43655954
123MINK10.43089860
124PAK60.42004612
125IRAK20.41270078
126FES0.41152116
127PRKCI0.39652872
128PRKCG0.37965873
129SGK20.37708922
130PRKAA20.35661699
131PTK2B0.35348916
132PRKG10.34583021
133FYN0.33371245
134MST1R0.32799764
135STK110.32747843
136PRKACA0.32625104
137PASK0.32274393
138GRK50.31868301
139MARK30.31419643
140BRSK10.30923959
141CSNK1D0.30911265
142MAP2K40.30369270
143MAP3K20.30293655
144CAMK40.30061292
145NME20.29290065
146IKBKB0.29255483
147PRKCZ0.29177357
148PRKAA10.28906072
149PLK10.28334953

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.52849666
2Oxidative phosphorylation_Homo sapiens_hsa001904.46529655
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.22194103
4Steroid biosynthesis_Homo sapiens_hsa001003.79736030
5Parkinsons disease_Homo sapiens_hsa050123.66312239
6Fatty acid elongation_Homo sapiens_hsa000623.57240037
7Proteasome_Homo sapiens_hsa030503.37042979
8Alzheimers disease_Homo sapiens_hsa050102.93988996
9Ribosome_Homo sapiens_hsa030102.69214476
10Huntingtons disease_Homo sapiens_hsa050162.60802775
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59594946
12RNA polymerase_Homo sapiens_hsa030202.58077402
13Nitrogen metabolism_Homo sapiens_hsa009102.29179392
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19055899
15Selenocompound metabolism_Homo sapiens_hsa004502.12695854
16Sulfur metabolism_Homo sapiens_hsa009202.07487652
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05023274
18Ether lipid metabolism_Homo sapiens_hsa005651.99846705
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89003746
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82923281
21Vitamin B6 metabolism_Homo sapiens_hsa007501.82686699
22Basal transcription factors_Homo sapiens_hsa030221.65325518
23Tryptophan metabolism_Homo sapiens_hsa003801.61255362
24Cardiac muscle contraction_Homo sapiens_hsa042601.56674580
25Taste transduction_Homo sapiens_hsa047421.48281780
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43249078
27Caffeine metabolism_Homo sapiens_hsa002321.35845425
28Collecting duct acid secretion_Homo sapiens_hsa049661.28871649
29Vibrio cholerae infection_Homo sapiens_hsa051101.27340068
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24607297
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23163202
32ABC transporters_Homo sapiens_hsa020101.21216914
33Chemical carcinogenesis_Homo sapiens_hsa052041.20546108
34beta-Alanine metabolism_Homo sapiens_hsa004101.18836711
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13983525
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.13263940
37Dorso-ventral axis formation_Homo sapiens_hsa043201.11861939
38Non-homologous end-joining_Homo sapiens_hsa034501.09186831
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.06609259
40Sphingolipid metabolism_Homo sapiens_hsa006001.06279651
41Ovarian steroidogenesis_Homo sapiens_hsa049131.00771691
42Retinol metabolism_Homo sapiens_hsa008300.99602109
43Glutathione metabolism_Homo sapiens_hsa004800.94474927
44Circadian rhythm_Homo sapiens_hsa047100.91730024
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89265317
46One carbon pool by folate_Homo sapiens_hsa006700.88718269
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87798785
48Serotonergic synapse_Homo sapiens_hsa047260.87123471
49Glycerolipid metabolism_Homo sapiens_hsa005610.84326587
50Histidine metabolism_Homo sapiens_hsa003400.83959286
51Glutamatergic synapse_Homo sapiens_hsa047240.80283064
52Calcium signaling pathway_Homo sapiens_hsa040200.80210200
53Salivary secretion_Homo sapiens_hsa049700.79240492
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.78812885
55Axon guidance_Homo sapiens_hsa043600.78218110
56GABAergic synapse_Homo sapiens_hsa047270.78025134
57Butanoate metabolism_Homo sapiens_hsa006500.77749983
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77669990
59Linoleic acid metabolism_Homo sapiens_hsa005910.77036560
60Metabolic pathways_Homo sapiens_hsa011000.75381532
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75121737
62Pyrimidine metabolism_Homo sapiens_hsa002400.74210389
63Homologous recombination_Homo sapiens_hsa034400.73255251
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67169075
65Spliceosome_Homo sapiens_hsa030400.67125335
66Purine metabolism_Homo sapiens_hsa002300.66990302
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.66960056
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66936627
69Nucleotide excision repair_Homo sapiens_hsa034200.65800660
70Nicotine addiction_Homo sapiens_hsa050330.65480370
71Amphetamine addiction_Homo sapiens_hsa050310.64917459
72Rheumatoid arthritis_Homo sapiens_hsa053230.63049746
73Renin secretion_Homo sapiens_hsa049240.61731562
74Folate biosynthesis_Homo sapiens_hsa007900.61321632
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59558576
76RNA degradation_Homo sapiens_hsa030180.59155559
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58572500
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58467153
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57905548
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57094171
81Morphine addiction_Homo sapiens_hsa050320.56513271
82Arachidonic acid metabolism_Homo sapiens_hsa005900.56468163
83Mismatch repair_Homo sapiens_hsa034300.56306458
84Autoimmune thyroid disease_Homo sapiens_hsa053200.55447978
85Arginine and proline metabolism_Homo sapiens_hsa003300.53541344
86Oxytocin signaling pathway_Homo sapiens_hsa049210.53491038
87Fatty acid degradation_Homo sapiens_hsa000710.52903924
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.52869931
89Circadian entrainment_Homo sapiens_hsa047130.52414378
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52362056
91Vitamin digestion and absorption_Homo sapiens_hsa049770.52111581
92Fat digestion and absorption_Homo sapiens_hsa049750.51826451
93Dopaminergic synapse_Homo sapiens_hsa047280.51042987
94Long-term depression_Homo sapiens_hsa047300.50405212
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49117155
96Cocaine addiction_Homo sapiens_hsa050300.48705500
97Sulfur relay system_Homo sapiens_hsa041220.47771292
98Mineral absorption_Homo sapiens_hsa049780.45682436
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45545563
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44622665
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44274289
102Propanoate metabolism_Homo sapiens_hsa006400.43874142
103Pentose phosphate pathway_Homo sapiens_hsa000300.42736547
104Alcoholism_Homo sapiens_hsa050340.42549189
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42221495
106Synaptic vesicle cycle_Homo sapiens_hsa047210.41715627
107cAMP signaling pathway_Homo sapiens_hsa040240.40835634
108Allograft rejection_Homo sapiens_hsa053300.40798910
109Oocyte meiosis_Homo sapiens_hsa041140.40476769
110Regulation of autophagy_Homo sapiens_hsa041400.39445030
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38412260
112Gastric acid secretion_Homo sapiens_hsa049710.37431196
113Pyruvate metabolism_Homo sapiens_hsa006200.36574941
114Hedgehog signaling pathway_Homo sapiens_hsa043400.36029114
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34677440
116Graft-versus-host disease_Homo sapiens_hsa053320.34247105
117Long-term potentiation_Homo sapiens_hsa047200.34162707
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32704927
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32533448
120Phototransduction_Homo sapiens_hsa047440.32398652
121Cholinergic synapse_Homo sapiens_hsa047250.31746591
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.31133389
123Fatty acid metabolism_Homo sapiens_hsa012120.29701797
124Pancreatic secretion_Homo sapiens_hsa049720.28621748
125Type I diabetes mellitus_Homo sapiens_hsa049400.27292925
126Fanconi anemia pathway_Homo sapiens_hsa034600.26397423
127Olfactory transduction_Homo sapiens_hsa047400.25672623
128Renal cell carcinoma_Homo sapiens_hsa052110.25320649
129Peroxisome_Homo sapiens_hsa041460.25042547
130RNA transport_Homo sapiens_hsa030130.22027829
131Insulin secretion_Homo sapiens_hsa049110.22008380
132Phagosome_Homo sapiens_hsa041450.21914997
133Ras signaling pathway_Homo sapiens_hsa040140.21189125
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20166036
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.19506646
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17903082
137ErbB signaling pathway_Homo sapiens_hsa040120.15747115
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15434197
139Gap junction_Homo sapiens_hsa045400.12991056

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »