DUSP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.49194347
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.97030364
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.97030364
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57688415
5regulation of gamma-delta T cell differentiation (GO:0045586)5.50735993
6antigen processing and presentation of endogenous antigen (GO:0019883)5.43908152
7regulation of chronic inflammatory response (GO:0002676)5.09293281
8regulation of gamma-delta T cell activation (GO:0046643)5.05347139
9regulation of vitamin D biosynthetic process (GO:0060556)4.97463170
10negative thymic T cell selection (GO:0045060)4.79032868
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.74485602
12negative T cell selection (GO:0043383)4.74437607
13NIK/NF-kappaB signaling (GO:0038061)4.71148514
14positive thymic T cell selection (GO:0045059)4.56304102
15regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.54010777
16positive regulation of B cell differentiation (GO:0045579)4.53040399
17regulation of interleukin-12 biosynthetic process (GO:0045075)4.46062403
18antigen processing and presentation via MHC class Ib (GO:0002475)4.42769979
19regulation of isotype switching to IgG isotypes (GO:0048302)4.24122797
20response to interleukin-15 (GO:0070672)4.19561816
21regulation of B cell receptor signaling pathway (GO:0050855)4.19145603
22negative regulation of interleukin-12 production (GO:0032695)4.17836843
23regulation of B cell differentiation (GO:0045577)4.17709236
24regulation of T-helper 1 cell differentiation (GO:0045625)4.14000009
25regulation of interleukin-2 biosynthetic process (GO:0045076)4.08407825
26ribosomal small subunit assembly (GO:0000028)3.96812390
27regulation of vitamin metabolic process (GO:0030656)3.85593339
28regulation of immunoglobulin secretion (GO:0051023)3.85369444
29T cell migration (GO:0072678)3.85328078
30leukocyte aggregation (GO:0070486)3.84780936
31cellular response to interleukin-15 (GO:0071350)3.82326254
32regulation of interferon-alpha production (GO:0032647)3.82210812
33thymic T cell selection (GO:0045061)3.81989774
34T cell homeostasis (GO:0043029)3.74554413
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72556099
36regulation of cytokine secretion involved in immune response (GO:0002739)3.70845161
37positive T cell selection (GO:0043368)3.68641881
38interferon-gamma production (GO:0032609)3.68251940
39regulation of regulatory T cell differentiation (GO:0045589)3.67931367
40myeloid dendritic cell activation (GO:0001773)3.66282723
41positive regulation of isotype switching (GO:0045830)3.65802492
42activation of MAPKKK activity (GO:0000185)3.65436982
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62181799
44negative regulation of cell killing (GO:0031342)3.62181799
45response to peptidoglycan (GO:0032494)3.61330045
46B cell receptor signaling pathway (GO:0050853)3.54947668
47viral transcription (GO:0019083)3.53703294
48regulation of alpha-beta T cell proliferation (GO:0046640)3.52299045
49T cell selection (GO:0045058)3.51016090
50myeloid dendritic cell differentiation (GO:0043011)3.50608046
51T-helper 1 type immune response (GO:0042088)3.47981641
52negative regulation of T cell mediated immunity (GO:0002710)3.43221260
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.42042515
54positive regulation of chemokine biosynthetic process (GO:0045080)3.41472914
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.40754469
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.40494121
57positive regulation of interferon-alpha production (GO:0032727)3.38861004
58immunoglobulin mediated immune response (GO:0016064)3.38841204
59translational termination (GO:0006415)3.38380347
60regulation of T cell receptor signaling pathway (GO:0050856)3.38025124
61mature B cell differentiation (GO:0002335)3.37926843
62positive regulation of heat generation (GO:0031652)3.37742817
63negative regulation of cytokine production involved in immune response (GO:0002719)3.34736531
64antigen receptor-mediated signaling pathway (GO:0050851)3.33827342
65regulation of fever generation (GO:0031620)3.32412569
66T cell receptor signaling pathway (GO:0050852)3.32007718
67defense response to protozoan (GO:0042832)3.31958289
68T cell lineage commitment (GO:0002360)3.31323797
69regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.30800283
70response to protozoan (GO:0001562)3.29855930
71regulation of interleukin-12 production (GO:0032655)3.29840620
72regulation of podosome assembly (GO:0071801)3.28921238
73positive regulation of humoral immune response (GO:0002922)3.27191918
74response to type I interferon (GO:0034340)3.24946562
75positive regulation of B cell mediated immunity (GO:0002714)3.23261693
76positive regulation of immunoglobulin mediated immune response (GO:0002891)3.23261693
77type I interferon signaling pathway (GO:0060337)3.22463150
78cellular response to type I interferon (GO:0071357)3.22463150
79lymphocyte homeostasis (GO:0002260)3.21872925
80mast cell activation (GO:0045576)3.20797802
81positive regulation by symbiont of host defense response (GO:0052509)3.20753951
82modulation by symbiont of host defense response (GO:0052031)3.20753951
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.20753951
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.20753951
85positive regulation by organism of defense response of other organism involved in symbiotic interact3.20753951
86modulation by symbiont of host immune response (GO:0052553)3.20753951
87negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.19556923
88positive regulation of alpha-beta T cell proliferation (GO:0046641)3.17708336
89cellular response to interferon-gamma (GO:0071346)3.17693363
90regulation of chemokine biosynthetic process (GO:0045073)3.17538977
91dendritic cell differentiation (GO:0097028)3.16689238
92positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.16009535
93T cell costimulation (GO:0031295)3.15589625
94Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14780930
95negative regulation of viral genome replication (GO:0045071)3.14359622
96regulation of dendritic cell antigen processing and presentation (GO:0002604)3.14241551
97tolerance induction (GO:0002507)3.13540177
98positive regulation of interleukin-2 production (GO:0032743)3.13050427
99regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.12205593
100negative regulation of erythrocyte differentiation (GO:0045647)3.11872543
101lymphocyte costimulation (GO:0031294)3.11636615
102positive regulation of DNA recombination (GO:0045911)3.11414719
103regulation of T-helper cell differentiation (GO:0045622)3.11318854
104JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.11243330
105regulation of type I interferon-mediated signaling pathway (GO:0060338)3.09882180
106regulation of response to interferon-gamma (GO:0060330)3.09785313
107interferon-gamma-mediated signaling pathway (GO:0060333)3.08100339
108positive regulation of interleukin-12 production (GO:0032735)3.07754986
109regulation of B cell mediated immunity (GO:0002712)3.06753787
110positive regulation of B cell proliferation (GO:0030890)3.06709158
111regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.06059294
112positive regulation of cytokine biosynthetic process (GO:0042108)3.05887727
113regulation of necroptotic process (GO:0060544)3.04771038
114regulation of isotype switching (GO:0045191)3.04750593
115Peyers patch development (GO:0048541)3.04298923
116mucosal-associated lymphoid tissue development (GO:0048537)3.04298923
117mature B cell differentiation involved in immune response (GO:0002313)3.04247422
118positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.03283131
119regulation of interferon-beta biosynthetic process (GO:0045357)3.03281641
120regulation of immunoglobulin mediated immune response (GO:0002889)3.03145023
121leukocyte homeostasis (GO:0001776)3.01816716
122negative regulation of myeloid cell apoptotic process (GO:0033033)3.01469571
123definitive hemopoiesis (GO:0060216)3.01221394
124macrophage activation involved in immune response (GO:0002281)3.00367129
125positive regulation of T cell mediated cytotoxicity (GO:0001916)3.00288079
126positive regulation of interferon-gamma production (GO:0032729)2.99635610
127positive regulation of type 2 immune response (GO:0002830)2.99459572
128positive regulation of interleukin-10 production (GO:0032733)2.98822318
129regulation of interleukin-2 production (GO:0032663)2.96802887
130regulation of T cell mediated cytotoxicity (GO:0001914)2.95248467
131lymph node development (GO:0048535)2.94941683
132CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.92890023
133positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.92539957
134positive regulation of natural killer cell mediated immunity (GO:0002717)2.92539957
135ribosomal small subunit biogenesis (GO:0042274)2.91463815
136translational elongation (GO:0006414)2.91127918
137T cell differentiation (GO:0030217)2.89452999
138response to muramyl dipeptide (GO:0032495)2.89428839
139natural killer cell activation (GO:0030101)2.88530030
140regulation of natural killer cell mediated immunity (GO:0002715)2.87731849
141regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.87731849
142B cell mediated immunity (GO:0019724)2.86388539
143megakaryocyte development (GO:0035855)2.85998818
144regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82538704
145positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.76424402
146SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76057348
147germinal center formation (GO:0002467)2.75928533
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75499886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.96039087
2E2F7_22180533_ChIP-Seq_HELA_Human4.41243166
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.22090310
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.12114621
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.69136942
6MYC_22102868_ChIP-Seq_BL_Human3.53664031
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.42590078
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20558878
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.01077292
10* SCL_19346495_ChIP-Seq_HPC-7_Human2.89805887
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.81904729
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77138942
13VDR_21846776_ChIP-Seq_THP-1_Human2.73250096
14* NOTCH1_21737748_ChIP-Seq_TLL_Human2.73105043
15* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65051401
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.64659176
17MYB_26560356_Chip-Seq_TH2_Human2.63312431
18* MAF_26560356_Chip-Seq_TH1_Human2.59127283
19* RUNX_20019798_ChIP-Seq_JUKART_Human2.58417118
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52000335
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.45758060
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.44581972
23* MYB_26560356_Chip-Seq_TH1_Human2.31861236
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31389530
25* UTX_26944678_Chip-Seq_JUKART_Human2.21245189
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20506268
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20257784
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15325215
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12227017
30* SPI1_23547873_ChIP-Seq_NB4_Human2.10966247
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10846486
32VDR_24763502_ChIP-Seq_THP-1_Human2.08416666
33BP1_19119308_ChIP-ChIP_Hs578T_Human2.06805431
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03755784
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02396445
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00901973
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98113081
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.97725013
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.96703509
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.88967488
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84349757
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73437120
43MAF_26560356_Chip-Seq_TH2_Human1.70202824
44* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69207079
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68707452
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.67487615
47* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61621616
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60889575
49* VDR_23849224_ChIP-Seq_CD4+_Human1.55682364
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54458279
51* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52324424
52CIITA_25753668_ChIP-Seq_RAJI_Human1.52278223
53* GATA3_27048872_Chip-Seq_THYMUS_Human1.48515632
54* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.46604581
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45739451
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44975598
57* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43482542
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42560167
59FOXP3_21729870_ChIP-Seq_TREG_Human1.42423407
60* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40016708
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37899371
62VDR_24787735_ChIP-Seq_THP-1_Human1.36290373
63KDM2B_26808549_Chip-Seq_DND41_Human1.36211785
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36074672
65* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35715584
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34582654
67GATA1_22025678_ChIP-Seq_K562_Human1.34289868
68SPI1_23127762_ChIP-Seq_K562_Human1.31699947
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.30265682
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29161778
71* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26086406
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22382238
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.20724780
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.20095917
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16046185
76XRN2_22483619_ChIP-Seq_HELA_Human1.13665121
77LXR_22292898_ChIP-Seq_THP-1_Human1.11574144
78PU_27001747_Chip-Seq_BMDM_Mouse1.09274947
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.08683565
80* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08087801
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06593149
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06131727
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05949811
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05426505
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02660982
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01959743
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01551072
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.01492399
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00924513
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00635823
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00581504
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00103083
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00073669
94MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97466858
95GATA3_26560356_Chip-Seq_TH2_Human0.96735193
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96310450
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95592491
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.94080113
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91731327
100ELK1_19687146_ChIP-ChIP_HELA_Human0.89841606
101BCOR_27268052_Chip-Seq_Bcells_Human0.88383786
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88363889
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.87913884
104BCL6_27268052_Chip-Seq_Bcells_Human0.87766607
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86642420
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.86094285
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85350418
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84548583
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84431653
110NCOR1_26117541_ChIP-Seq_K562_Human0.84320543
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.83839495
112DCP1A_22483619_ChIP-Seq_HELA_Human0.83627514
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82853391
114ETS1_20019798_ChIP-Seq_JURKAT_Human0.82470636
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81759497
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81273952
117TFEB_21752829_ChIP-Seq_HELA_Human0.79770004
118SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79526799
119GATA1_19941826_ChIP-Seq_K562_Human0.78966224
120* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78909435
121NELFA_20434984_ChIP-Seq_ESCs_Mouse0.78876176
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78543075
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77977408
124CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76627230
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75508551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.08379751
2MP0003763_abnormal_thymus_physiology4.01931647
3MP0005671_abnormal_response_to3.99197093
4MP0000685_abnormal_immune_system3.79586253
5MP0001800_abnormal_humoral_immune3.31129942
6MP0002396_abnormal_hematopoietic_system3.09300721
7MP0009785_altered_susceptibility_to3.02962592
8MP0002166_altered_tumor_susceptibility2.90715239
9MP0005387_immune_system_phenotype2.88484904
10MP0001790_abnormal_immune_system2.88484904
11* MP0005000_abnormal_immune_tolerance2.86141033
12MP0002398_abnormal_bone_marrow2.80970892
13* MP0002452_abnormal_antigen_presenting2.77926054
14* MP0002723_abnormal_immune_serum2.77595206
15* MP0002420_abnormal_adaptive_immunity2.76010557
16* MP0001819_abnormal_immune_cell2.71942046
17MP0005025_abnormal_response_to2.55216297
18* MP0003436_decreased_susceptibility_to2.49838665
19MP0000716_abnormal_immune_system2.41839011
20MP0001853_heart_inflammation2.32254385
21MP0000689_abnormal_spleen_morphology2.30531832
22MP0002405_respiratory_system_inflammati2.28154327
23MP0002006_tumorigenesis2.25290327
24MP0009333_abnormal_splenocyte_physiolog2.23617013
25MP0002722_abnormal_immune_system2.22729407
26MP0001873_stomach_inflammation2.20627295
27MP0000703_abnormal_thymus_morphology2.16617233
28MP0004808_abnormal_hematopoietic_stem2.15602610
29MP0010155_abnormal_intestine_physiology2.13935653
30MP0003303_peritoneal_inflammation2.11189247
31MP0003724_increased_susceptibility_to2.10239012
32MP0002148_abnormal_hypersensitivity_rea2.10073586
33MP0003866_abnormal_defecation2.07280354
34MP0002429_abnormal_blood_cell2.06608791
35MP0003300_gastrointestinal_ulcer2.06535379
36MP0004510_myositis2.05762774
37* MP0002419_abnormal_innate_immunity2.03774514
38MP0005464_abnormal_platelet_physiology2.00226359
39MP0005451_abnormal_body_composition1.94329011
40MP0004947_skin_inflammation1.90199272
41MP0005397_hematopoietic_system_phenotyp1.79019679
42MP0001545_abnormal_hematopoietic_system1.79019679
43MP0000465_gastrointestinal_hemorrhage1.76864042
44MP0002933_joint_inflammation1.69509963
45MP0006082_CNS_inflammation1.68023705
46MP0001845_abnormal_inflammatory_respons1.62932019
47MP0008057_abnormal_DNA_replication1.54193298
48MP0005174_abnormal_tail_pigmentation1.53540870
49MP0000490_abnormal_crypts_of1.51960619
50MP0005075_abnormal_melanosome_morpholog1.41914298
51MP0009278_abnormal_bone_marrow1.37377598
52MP0005058_abnormal_lysosome_morphology1.37110432
53MP0002139_abnormal_hepatobiliary_system1.32425240
54MP0002138_abnormal_hepatobiliary_system1.26305394
55MP0003075_altered_response_to1.24233030
56MP0008469_abnormal_protein_level1.19959504
57MP0000858_altered_metastatic_potential1.19689402
58MP0002019_abnormal_tumor_incidence1.18449468
59MP0009840_abnormal_foam_cell1.17938206
60MP0005310_abnormal_salivary_gland1.17444489
61MP0010352_gastrointestinal_tract_polyps1.09665776
62MP0008007_abnormal_cellular_replicative1.08959191
63MP0008004_abnormal_stomach_pH1.08726364
64MP0002095_abnormal_skin_pigmentation1.05651397
65MP0002332_abnormal_exercise_endurance1.03922297
66MP0005166_decreased_susceptibility_to1.00714942
67MP0003077_abnormal_cell_cycle0.99774782
68MP0010094_abnormal_chromosome_stability0.99247611
69* MP0001533_abnormal_skeleton_physiology0.98748915
70MP0002132_abnormal_respiratory_system0.97441418
71MP0003448_altered_tumor_morphology0.97264195
72MP0000015_abnormal_ear_pigmentation0.93606400
73MP0001851_eye_inflammation0.93153736
74MP0000604_amyloidosis0.91308224
75MP0003693_abnormal_embryo_hatching0.88885619
76MP0003091_abnormal_cell_migration0.81858924
77MP0002009_preneoplasia0.80279681
78MP0005167_abnormal_blood-brain_barrier0.79921368
79MP0003045_fibrosis0.77887931
80MP0008058_abnormal_DNA_repair0.77549803
81MP0006054_spinal_hemorrhage0.75489013
82MP0001501_abnormal_sleep_pattern0.74698832
83MP0002693_abnormal_pancreas_physiology0.73253088
84MP0005076_abnormal_cell_differentiation0.70914181
85MP0004957_abnormal_blastocyst_morpholog0.70696408
86MP0000313_abnormal_cell_death0.70080762
87MP0001348_abnormal_lacrimal_gland0.68832777
88MP0009764_decreased_sensitivity_to0.68149451
89MP0003943_abnormal_hepatobiliary_system0.67748303
90MP0003172_abnormal_lysosome_physiology0.65582550
91MP0009763_increased_sensitivity_to0.65093383
92MP0002163_abnormal_gland_morphology0.64220479
93MP0003828_pulmonary_edema0.63976434
94MP0004381_abnormal_hair_follicle0.63960862
95MP0001663_abnormal_digestive_system0.63458453
96MP0002998_abnormal_bone_remodeling0.62327505
97MP0005165_increased_susceptibility_to0.61370590
98* MP0005390_skeleton_phenotype0.60926054
99MP0008874_decreased_physiological_sensi0.60451928
100MP0001542_abnormal_bone_strength0.60346262
101MP0001727_abnormal_embryo_implantation0.59199651
102MP0000609_abnormal_liver_physiology0.58199430
103MP0009765_abnormal_xenobiotic_induced0.58181365
104MP0000371_diluted_coat_color0.57783531
105MP0008961_abnormal_basal_metabolism0.57754933
106MP0005023_abnormal_wound_healing0.56296510
107MP0000477_abnormal_intestine_morphology0.55554862
108MP0005647_abnormal_sex_gland0.55454949
109MP0000249_abnormal_blood_vessel0.55423855
110MP0000350_abnormal_cell_proliferation0.52962362
111MP0005535_abnormal_body_temperature0.52929920
112MP0003453_abnormal_keratinocyte_physiol0.52457505
113MP0005645_abnormal_hypothalamus_physiol0.52007470
114MP0001879_abnormal_lymphatic_vessel0.51280163
115MP0008260_abnormal_autophagy0.50985372
116MP0002928_abnormal_bile_duct0.50507123
117MP0003111_abnormal_nucleus_morphology0.50295885
118MP0002136_abnormal_kidney_physiology0.48727417
119MP0001919_abnormal_reproductive_system0.48174723
120MP0001191_abnormal_skin_condition0.47915123
121MP0010307_abnormal_tumor_latency0.46794217
122MP0003656_abnormal_erythrocyte_physiolo0.45223008
123MP0000598_abnormal_liver_morphology0.44963862
124MP0003795_abnormal_bone_structure0.44502337
125MP0000343_altered_response_to0.43917595
126MP0002254_reproductive_system_inflammat0.43052759
127MP0003183_abnormal_peptide_metabolism0.42843789

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.95088881
2Chronic otitis media (HP:0000389)4.84395917
3Recurrent bronchitis (HP:0002837)4.68811477
4Panhypogammaglobulinemia (HP:0003139)4.62278673
5Thrombocytosis (HP:0001894)4.54903393
6Stomatitis (HP:0010280)4.47561203
7IgM deficiency (HP:0002850)4.46069921
8Abnormality of B cell number (HP:0010975)4.35197376
9B lymphocytopenia (HP:0010976)4.35197376
10T lymphocytopenia (HP:0005403)4.32176491
11Recurrent fungal infections (HP:0002841)4.20719400
12Abnormality of T cell number (HP:0011839)4.16255310
13Recurrent viral infections (HP:0004429)4.11169227
14Abnormality of T cells (HP:0002843)4.06706048
15Severe combined immunodeficiency (HP:0004430)4.03504358
16IgG deficiency (HP:0004315)4.02047806
17Myositis (HP:0100614)3.99437845
18Nasal polyposis (HP:0100582)3.93394317
19Agammaglobulinemia (HP:0004432)3.89150074
20Eczematoid dermatitis (HP:0000976)3.86830374
21Autoimmune hemolytic anemia (HP:0001890)3.78245504
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.76985208
23Keratoconjunctivitis sicca (HP:0001097)3.69563351
24Abnormality of the nasal mucosa (HP:0000433)3.66866191
25Recurrent abscess formation (HP:0002722)3.60016054
26Recurrent cutaneous fungal infections (HP:0011370)3.59338327
27Chronic mucocutaneous candidiasis (HP:0002728)3.59338327
28Abnormality of T cell physiology (HP:0011840)3.55759348
29Combined immunodeficiency (HP:0005387)3.55207975
30Abnormality of liposaccharide metabolism (HP:0010968)3.47950307
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.47950307
32Abnormality of glycolipid metabolism (HP:0010969)3.47950307
33Lymphopenia (HP:0001888)3.44096518
34Keratoconjunctivitis (HP:0001096)3.42801487
35Aplastic anemia (HP:0001915)3.36200810
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.32630629
37Meningitis (HP:0001287)3.29818322
38Thyroiditis (HP:0100646)3.29730155
39Inflammation of the large intestine (HP:0002037)3.27293770
40Gastrointestinal inflammation (HP:0004386)3.22950618
41Vasculitis (HP:0002633)3.22297094
42Recurrent bacterial skin infections (HP:0005406)3.12898010
43Gastrointestinal stroma tumor (HP:0100723)3.12830139
44Mediastinal lymphadenopathy (HP:0100721)3.09801990
45Gangrene (HP:0100758)3.09039432
46Colitis (HP:0002583)3.04490327
47Chronic diarrhea (HP:0002028)3.04121882
48Lymphoma (HP:0002665)3.02628779
49Spontaneous hematomas (HP:0007420)2.92421727
50Recurrent skin infections (HP:0001581)2.91013821
51Cellulitis (HP:0100658)2.85869959
52Fatigue (HP:0012378)2.83426886
53Recurrent sinusitis (HP:0011108)2.81723375
54Leukocytosis (HP:0001974)2.80794424
55Abnormality of cells of the erythroid lineage (HP:0012130)2.79261038
56Reticulocytopenia (HP:0001896)2.78118966
57Abnormality of eosinophils (HP:0001879)2.77479529
58Amaurosis fugax (HP:0100576)2.76104218
59Abnormality of the fingertips (HP:0001211)2.75352599
60Chronic sinusitis (HP:0011109)2.72239021
61Abnormal number of erythroid precursors (HP:0012131)2.70853415
62Increased IgE level (HP:0003212)2.70601939
63Epistaxis (HP:0000421)2.68768338
64Restrictive lung disease (HP:0002091)2.68499433
65Increased IgM level (HP:0003496)2.68110680
66Bronchitis (HP:0012387)2.65167949
67Chest pain (HP:0100749)2.64411102
68Arterial thrombosis (HP:0004420)2.64246296
69Prolonged bleeding time (HP:0003010)2.64102855
70Abnormality of the pleura (HP:0002103)2.62963362
71Pustule (HP:0200039)2.62283137
72Retrobulbar optic neuritis (HP:0100654)2.62261617
73Optic neuritis (HP:0100653)2.62261617
74Hypoplasia of the thymus (HP:0000778)2.62163473
75IgA deficiency (HP:0002720)2.61868693
76Acute myeloid leukemia (HP:0004808)2.60120446
77Hypergammaglobulinemia (HP:0010702)2.59846960
78Petechiae (HP:0000967)2.57687229
79Pulmonary infiltrates (HP:0002113)2.54807936
80Vacuolated lymphocytes (HP:0001922)2.51158993
81Urticaria (HP:0001025)2.49540458
82Abnormal platelet function (HP:0011869)2.49103449
83Impaired platelet aggregation (HP:0003540)2.49103449
84Orchitis (HP:0100796)2.48252581
85Arthralgia (HP:0002829)2.46435961
86Dysostosis multiplex (HP:0000943)2.45456282
87Emphysema (HP:0002097)2.45155602
88Hemoptysis (HP:0002105)2.45061489
89Gastrointestinal infarctions (HP:0005244)2.42215511
90Loss of speech (HP:0002371)2.40970440
91Chronic obstructive pulmonary disease (HP:0006510)2.40669712
92Obstructive lung disease (HP:0006536)2.40669712
93Recurrent gram-negative bacterial infections (HP:0005420)2.39952599
94Eosinophilia (HP:0001880)2.39895439
95Poikiloderma (HP:0001029)2.36775905
96Granulocytopenia (HP:0001913)2.35474376
97Encephalitis (HP:0002383)2.35362319
98Polyneuropathy (HP:0001271)2.34002735
99Systemic lupus erythematosus (HP:0002725)2.32806649
100Interstitial pulmonary disease (HP:0006530)2.27153615
101Anorexia (HP:0002039)2.26843860
102Gingival bleeding (HP:0000225)2.26172198
103Papilloma (HP:0012740)2.24806307
104Verrucae (HP:0200043)2.24806307
105Abnormality of macrophages (HP:0004311)2.23994971
106Pallor (HP:0000980)2.23487373
107Microcytic anemia (HP:0001935)2.22592704
108Pulmonary embolism (HP:0002204)2.19228724
109Parakeratosis (HP:0001036)2.19223281
110Recurrent lower respiratory tract infections (HP:0002783)2.18435700
111Recurrent pneumonia (HP:0006532)2.17751428
112Keratitis (HP:0000491)2.17646285
113Glomerulopathy (HP:0100820)2.17441256
114Neutropenia (HP:0001875)2.17218851
115Increased serum ferritin (HP:0003281)2.15796441
116Hypertensive crisis (HP:0100735)2.15444642
117Autoimmune thrombocytopenia (HP:0001973)2.14414785
118Hematochezia (HP:0002573)2.12091649
119Acute hepatic failure (HP:0006554)2.11257038
120Abnormality of the prostate (HP:0008775)2.08672849
121Increased density of long bones (HP:0006392)2.03064247
122Increased cerebral lipofuscin (HP:0011813)2.02824277
123Hypoproteinemia (HP:0003075)2.02058331
124Osteomyelitis (HP:0002754)2.01530371
125Pancytopenia (HP:0001876)2.00408200
126Albinism (HP:0001022)2.00049144
127Joint swelling (HP:0001386)1.96913467
128Basal cell carcinoma (HP:0002671)1.96350692
129Basal ganglia calcification (HP:0002135)1.93119856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.45787705
2TXK3.79790455
3PRPF4B3.61609233
4JAK33.12455614
5ZAP702.83943534
6MAP3K142.69482388
7TYK22.43042595
8KIT2.39356908
9TBK12.39324519
10IKBKE2.37647403
11EEF2K2.26570333
12MAP3K102.24390874
13PIM22.16420004
14BMPR22.10714791
15ITK2.05325848
16BTK2.04285738
17TEC2.03868946
18IKBKB1.98202743
19KDR1.84856524
20NLK1.82410445
21IRAK41.73635924
22SYK1.72394985
23NME21.71245836
24CSF1R1.64027715
25FGFR41.62231371
26LCK1.61760077
27GRK61.61314195
28GRK71.59508419
29STK101.46731402
30FLT31.40053498
31JAK11.39034031
32MAP2K31.38654090
33BLK1.28721724
34CHUK1.27100142
35FES1.24371764
36PIM11.24211605
37MAP3K131.23601019
38DDR21.21315770
39TGFBR11.20731753
40HCK1.20240244
41TAOK31.19200513
42LRRK21.17923178
43RPS6KA41.17383764
44FGFR31.16179588
45TGFBR21.11593444
46CSK1.11471005
47LYN1.04798047
48MAP3K111.03641681
49DYRK30.96994341
50TESK20.95805415
51FGR0.95281793
52SMG10.91698684
53NEK90.90952139
54MOS0.88776579
55IRAK20.87708027
56RIPK10.86942841
57IRAK30.85110389
58RPS6KB20.84766508
59CDC42BPA0.82836409
60RAF10.78806010
61EPHB10.77432654
62TSSK60.77391585
63SIK30.77135694
64CLK10.77055041
65MAPK70.74569060
66MAP3K10.70661697
67MAP3K50.70191292
68TLK10.68830279
69SIK20.68089329
70EIF2AK30.67834646
71TYRO30.67502355
72JAK20.65160560
73TRIB30.63817734
74RIPK40.63748090
75HIPK20.63198157
76ERN10.62812493
77MAP3K70.62463553
78MAPK40.61807765
79TAOK10.60850296
80CDK120.60296218
81EPHA30.59289099
82BRD40.59164093
83PKN20.58549827
84PRKCQ0.56210208
85MAP3K120.55240819
86NEK20.53747907
87RPS6KA50.53187554
88CDK190.51834060
89TNK20.51603554
90MAPKAPK30.51513324
91IRAK10.51276710
92TAOK20.49878711
93CDK40.48200718
94STK240.46583860
95MAP2K20.44742125
96MAP3K30.44613069
97VRK10.44324855
98PASK0.43720952
99SIK10.43668619
100WEE10.43638742
101MAP3K80.43635435
102CAMKK10.43606850
103MATK0.43604380
104CDK90.43263201
105DAPK30.41953730
106TNIK0.41625159
107EIF2AK20.40670345
108MARK30.40106406
109ADRBK20.38808952
110PRKCH0.38261735
111MAPKAPK20.38126431
112INSR0.36642105
113MST40.36505502
114PKN10.35819053
115ABL10.34840734
116ACVR1B0.34607687
117TIE10.33741241
118ARAF0.31860681
119CDC70.31520227
120ALK0.31476202
121RPS6KA60.31448644
122SCYL20.31369892
123MELK0.31012745
124RPS6KC10.30574727
125RPS6KL10.30574727
126ATR0.29973998
127MAPK110.29188488
128MAPK120.28763551
129MAPK30.28412564
130STK40.27777926
131PDK20.27700641
132PDK10.27182173
133MARK20.26552059
134RPS6KA10.24134447

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.28968478
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.91221399
3T cell receptor signaling pathway_Homo sapiens_hsa046602.53279198
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.51143767
5B cell receptor signaling pathway_Homo sapiens_hsa046622.50377641
6Allograft rejection_Homo sapiens_hsa053302.50138113
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.48961502
8Measles_Homo sapiens_hsa051622.44279505
9Leishmaniasis_Homo sapiens_hsa051402.41107830
10Antigen processing and presentation_Homo sapiens_hsa046122.40430785
11Ribosome_Homo sapiens_hsa030102.37064694
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.26212585
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09353299
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09339334
15Graft-versus-host disease_Homo sapiens_hsa053322.03161295
16Osteoclast differentiation_Homo sapiens_hsa043801.98666801
17DNA replication_Homo sapiens_hsa030301.91885872
18Hematopoietic cell lineage_Homo sapiens_hsa046401.87435237
19Herpes simplex infection_Homo sapiens_hsa051681.85739819
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.71970543
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56255834
22Acute myeloid leukemia_Homo sapiens_hsa052211.54643148
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54553325
24Base excision repair_Homo sapiens_hsa034101.47767173
25Mismatch repair_Homo sapiens_hsa034301.44912854
26Toxoplasmosis_Homo sapiens_hsa051451.44004203
27TNF signaling pathway_Homo sapiens_hsa046681.42530961
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42257337
29Autoimmune thyroid disease_Homo sapiens_hsa053201.40699206
30Hepatitis B_Homo sapiens_hsa051611.36535925
31Shigellosis_Homo sapiens_hsa051311.35721760
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29804234
33Influenza A_Homo sapiens_hsa051641.28404805
34Spliceosome_Homo sapiens_hsa030401.27791182
35Asthma_Homo sapiens_hsa053101.25906727
36Legionellosis_Homo sapiens_hsa051341.25351191
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25148954
38Apoptosis_Homo sapiens_hsa042101.25129028
39Viral myocarditis_Homo sapiens_hsa054161.23680260
40Epstein-Barr virus infection_Homo sapiens_hsa051691.23259233
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20165324
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12533567
43Type I diabetes mellitus_Homo sapiens_hsa049401.09917573
44Malaria_Homo sapiens_hsa051441.09151644
45HTLV-I infection_Homo sapiens_hsa051661.08350340
46Non-homologous end-joining_Homo sapiens_hsa034501.08218944
47Chronic myeloid leukemia_Homo sapiens_hsa052201.08127743
48Chemokine signaling pathway_Homo sapiens_hsa040621.07940106
49Pertussis_Homo sapiens_hsa051331.00655059
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.96559456
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96539480
52Viral carcinogenesis_Homo sapiens_hsa052030.94420655
53Platelet activation_Homo sapiens_hsa046110.89789963
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88705131
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85037656
56Salmonella infection_Homo sapiens_hsa051320.84601695
57Tuberculosis_Homo sapiens_hsa051520.84497725
58p53 signaling pathway_Homo sapiens_hsa041150.80989148
59Prolactin signaling pathway_Homo sapiens_hsa049170.80088642
60Homologous recombination_Homo sapiens_hsa034400.78298353
61Hepatitis C_Homo sapiens_hsa051600.78191805
62Nucleotide excision repair_Homo sapiens_hsa034200.75919896
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75880607
64Pancreatic cancer_Homo sapiens_hsa052120.75846065
65Small cell lung cancer_Homo sapiens_hsa052220.74484190
66RNA degradation_Homo sapiens_hsa030180.73585352
67Pyrimidine metabolism_Homo sapiens_hsa002400.72742267
68Colorectal cancer_Homo sapiens_hsa052100.70782306
69Lysosome_Homo sapiens_hsa041420.65850264
70Proteasome_Homo sapiens_hsa030500.64934905
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64732658
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.64181360
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63655887
74Prion diseases_Homo sapiens_hsa050200.63322259
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63210045
76RNA polymerase_Homo sapiens_hsa030200.61174392
77African trypanosomiasis_Homo sapiens_hsa051430.60735591
78Systemic lupus erythematosus_Homo sapiens_hsa053220.60558670
79Phagosome_Homo sapiens_hsa041450.56587743
80VEGF signaling pathway_Homo sapiens_hsa043700.56518061
81Cell cycle_Homo sapiens_hsa041100.53996743
82Thyroid cancer_Homo sapiens_hsa052160.53731027
83Fanconi anemia pathway_Homo sapiens_hsa034600.52770187
84Type II diabetes mellitus_Homo sapiens_hsa049300.51004056
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49984985
86RNA transport_Homo sapiens_hsa030130.48222181
87Rheumatoid arthritis_Homo sapiens_hsa053230.46334679
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45127467
89Notch signaling pathway_Homo sapiens_hsa043300.43859494
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41768342
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41228145
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.40764337
93Non-small cell lung cancer_Homo sapiens_hsa052230.40509545
94Bladder cancer_Homo sapiens_hsa052190.36185876
95HIF-1 signaling pathway_Homo sapiens_hsa040660.34002021
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.33639980
97One carbon pool by folate_Homo sapiens_hsa006700.33290237
98* MAPK signaling pathway_Homo sapiens_hsa040100.32688805
99Staphylococcus aureus infection_Homo sapiens_hsa051500.30860516
100MicroRNAs in cancer_Homo sapiens_hsa052060.28734890
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28362463
102Other glycan degradation_Homo sapiens_hsa005110.26671238
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26495418
104Pathways in cancer_Homo sapiens_hsa052000.25741200
105FoxO signaling pathway_Homo sapiens_hsa040680.24670786
106Insulin resistance_Homo sapiens_hsa049310.24566393
107Sulfur relay system_Homo sapiens_hsa041220.24409548
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.24031036
109Alcoholism_Homo sapiens_hsa050340.23052975
110Caffeine metabolism_Homo sapiens_hsa002320.23012601
111Amoebiasis_Homo sapiens_hsa051460.21397885
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20964986
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20631829
114Prostate cancer_Homo sapiens_hsa052150.16848918
115mTOR signaling pathway_Homo sapiens_hsa041500.12348077
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11509163
117Renal cell carcinoma_Homo sapiens_hsa052110.10430603
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09024843
119Endocytosis_Homo sapiens_hsa041440.07959390
120Fructose and mannose metabolism_Homo sapiens_hsa000510.07605331
121Sphingolipid metabolism_Homo sapiens_hsa006000.07194196
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01745342
123ErbB signaling pathway_Homo sapiens_hsa040120.01159498
124GnRH signaling pathway_Homo sapiens_hsa04912-0.0517283

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