DUSP23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymphoid progenitor cell differentiation (GO:0002320)4.88566594
2DNA deamination (GO:0045006)4.82271012
3facial nerve structural organization (GO:0021612)4.76286933
4ribosomal small subunit assembly (GO:0000028)4.67558811
5proteasome assembly (GO:0043248)4.52459389
6respiratory chain complex IV assembly (GO:0008535)4.51723233
7GPI anchor biosynthetic process (GO:0006506)4.42164634
8platelet dense granule organization (GO:0060155)4.35159195
9mannosylation (GO:0097502)4.23883594
10ribosomal small subunit biogenesis (GO:0042274)4.21645585
11viral transcription (GO:0019083)4.18025070
12positive regulation of cellular amine metabolic process (GO:0033240)4.09217241
13presynaptic membrane assembly (GO:0097105)3.98399232
14translational termination (GO:0006415)3.92980143
15short-term memory (GO:0007614)3.88202967
16cotranslational protein targeting to membrane (GO:0006613)3.82661702
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82503001
18GPI anchor metabolic process (GO:0006505)3.79937974
19protein targeting to ER (GO:0045047)3.76179604
20postsynaptic membrane organization (GO:0001941)3.67256877
21C-terminal protein lipidation (GO:0006501)3.67070481
22response to interferon-beta (GO:0035456)3.65600588
23regulation of pigment cell differentiation (GO:0050932)3.64781711
24response to folic acid (GO:0051593)3.64467639
25protein localization to endoplasmic reticulum (GO:0070972)3.63728776
26cytochrome complex assembly (GO:0017004)3.60165602
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58385785
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52847528
29purine deoxyribonucleotide catabolic process (GO:0009155)3.48642711
30cranial nerve structural organization (GO:0021604)3.45458779
31protein maturation by protein folding (GO:0022417)3.42322942
32immunoglobulin mediated immune response (GO:0016064)3.40643123
33mature B cell differentiation (GO:0002335)3.37583972
34deoxyribonucleotide catabolic process (GO:0009264)3.37373969
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34106640
36pattern specification involved in kidney development (GO:0061004)3.30692899
37pinocytosis (GO:0006907)3.30691587
38deoxyribose phosphate catabolic process (GO:0046386)3.30287966
39presynaptic membrane organization (GO:0097090)3.29051742
40negative regulation of transcription by competitive promoter binding (GO:0010944)3.28205606
41neutrophil activation involved in immune response (GO:0002283)3.25823760
42preassembly of GPI anchor in ER membrane (GO:0016254)3.25776727
43mesonephros development (GO:0001823)3.19961610
44L-fucose catabolic process (GO:0042355)3.16887252
45fucose catabolic process (GO:0019317)3.16887252
46L-fucose metabolic process (GO:0042354)3.16887252
47L-phenylalanine metabolic process (GO:0006558)3.16709278
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.16709278
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.14618522
50ATP synthesis coupled proton transport (GO:0015986)3.14618522
51negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.11319116
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07726163
53regulation of mitochondrial translation (GO:0070129)3.07303653
54amino sugar catabolic process (GO:0046348)3.06675606
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06256518
56cranial nerve morphogenesis (GO:0021602)3.05645120
57respiratory electron transport chain (GO:0022904)3.04603592
58central nervous system myelination (GO:0022010)3.04072532
59axon ensheathment in central nervous system (GO:0032291)3.04072532
60mature B cell differentiation involved in immune response (GO:0002313)3.03479853
61translational elongation (GO:0006414)3.03293208
62cellular response to zinc ion (GO:0071294)3.02689748
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02398542
64C-terminal protein amino acid modification (GO:0018410)3.01766686
65nucleotide salvage (GO:0043173)3.01321818
66regulation of cellular amino acid metabolic process (GO:0006521)2.98615238
67electron transport chain (GO:0022900)2.97011874
68viral life cycle (GO:0019058)2.96501758
69maturation of SSU-rRNA (GO:0030490)2.96412206
70endothelium development (GO:0003158)2.95264850
71response to interferon-alpha (GO:0035455)2.92408711
72negative regulation of T-helper cell differentiation (GO:0045623)2.92287165
73negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92287165
74developmental pigmentation (GO:0048066)2.91026494
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89724208
76deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.87668255
77purine nucleotide salvage (GO:0032261)2.87452525
78negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.87201057
79N-acetylneuraminate metabolic process (GO:0006054)2.86392979
80negative regulation of metanephros development (GO:0072217)2.84298483
81L-phenylalanine catabolic process (GO:0006559)2.82995198
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.82995198
83phospholipid scrambling (GO:0017121)2.81347541
84heme metabolic process (GO:0042168)2.80489036
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79651411
86pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79145668
87autophagic vacuole fusion (GO:0000046)2.77956439
88cellular protein complex disassembly (GO:0043624)2.77650422
89negative regulation of erythrocyte differentiation (GO:0045647)2.75437817
90GTP biosynthetic process (GO:0006183)2.73452100
91negative regulation of leukocyte chemotaxis (GO:0002689)2.72801215
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72254970
93B cell mediated immunity (GO:0019724)2.72076134
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71126008
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70767366
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.70195774
97termination of RNA polymerase III transcription (GO:0006386)2.70195774
98androgen biosynthetic process (GO:0006702)2.69797645
99negative regulation of B cell apoptotic process (GO:0002903)2.69327224
100cellular response to interferon-beta (GO:0035458)2.69222841
101negative regulation of myotube differentiation (GO:0010832)2.69068983
102mast cell activation (GO:0045576)2.68158423
103negative regulation of execution phase of apoptosis (GO:1900118)2.66409817
104nephron tubule formation (GO:0072079)2.66407326
105oxidative phosphorylation (GO:0006119)2.65889557
106deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.64630891
107regulation of superoxide anion generation (GO:0032928)2.64025858
108DNA ligation (GO:0006266)2.63901421
109pyrimidine nucleoside salvage (GO:0043097)2.62945537
110pyrimidine-containing compound salvage (GO:0008655)2.62945537
1112-deoxyribonucleotide metabolic process (GO:0009394)2.62719646
112telomere maintenance via semi-conservative replication (GO:0032201)2.62145671
113DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61952061
114defense response to protozoan (GO:0042832)2.61810378
115negative regulation of myeloid cell apoptotic process (GO:0033033)2.61667207
116deoxyribose phosphate metabolic process (GO:0019692)2.60764632
117negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60689206
118nucleoside salvage (GO:0043174)2.60517637
119protein heterotetramerization (GO:0051290)2.60306402
120regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.60241829
121pyrimidine nucleotide catabolic process (GO:0006244)2.59267231
122deoxyribose phosphate biosynthetic process (GO:0046385)2.58665868
1232-deoxyribonucleotide biosynthetic process (GO:0009265)2.58665868
124purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.58304019
125thyroid gland development (GO:0030878)2.57471363
126nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.57438325
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56638776
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.56638776
129NADH dehydrogenase complex assembly (GO:0010257)2.56638776
130dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.56036951
131heme biosynthetic process (GO:0006783)2.55968413
132regulation of T cell mediated cytotoxicity (GO:0001914)2.55325745
133protein targeting to mitochondrion (GO:0006626)2.54752634
134negative regulation of nitric oxide biosynthetic process (GO:0045019)2.54642441
135establishment of protein localization to mitochondrial membrane (GO:0090151)2.53586006
136cyclooxygenase pathway (GO:0019371)2.53449603
137response to peptidoglycan (GO:0032494)2.53445219
138negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.53420855
139GMP metabolic process (GO:0046037)2.51368147
140intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51339542
141signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51339542
142base-excision repair, AP site formation (GO:0006285)2.50510462
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49897897
144negative regulation of ligase activity (GO:0051352)2.49897897
145definitive hemopoiesis (GO:0060216)2.49451985
146purine deoxyribonucleotide metabolic process (GO:0009151)2.49373504
147protein complex biogenesis (GO:0070271)2.48537889
148negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.48265163
149positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48161731
150ribosomal large subunit biogenesis (GO:0042273)2.47011433
151signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.46975187
152signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.46975187
153signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.46975187
154fucosylation (GO:0036065)2.46904472
155glycolipid biosynthetic process (GO:0009247)2.46335307
156mitochondrial respiratory chain complex assembly (GO:0033108)2.46155054
157lipopolysaccharide metabolic process (GO:0008653)2.44787368
158tRNA methylation (GO:0030488)2.44065103
159regulation of developmental pigmentation (GO:0048070)2.43442060
160omega-hydroxylase P450 pathway (GO:0097267)2.43201833
161GDP-mannose metabolic process (GO:0019673)2.42976901
162chaperone-mediated protein transport (GO:0072321)2.42380387
163negative regulation of interleukin-12 production (GO:0032695)2.42323367
164mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42309942
165lipopolysaccharide biosynthetic process (GO:0009103)2.39483598
166daunorubicin metabolic process (GO:0044597)2.39345544
167doxorubicin metabolic process (GO:0044598)2.39345544
168antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.38893656
169pentose metabolic process (GO:0019321)2.38701317
170signal transduction involved in DNA damage checkpoint (GO:0072422)2.36575275
171signal transduction involved in DNA integrity checkpoint (GO:0072401)2.36575275
172NIK/NF-kappaB signaling (GO:0038061)2.36433700
173lipoxygenase pathway (GO:0019372)2.36116076
174positive regulation of antigen processing and presentation (GO:0002579)2.34706332
175response to thyroid hormone (GO:0097066)2.32347515
176regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.30730832
177galactose catabolic process (GO:0019388)2.29290272
178regulation of chemokine biosynthetic process (GO:0045073)2.28844528
179signal transduction involved in cell cycle checkpoint (GO:0072395)2.27874881
180cellular metabolic compound salvage (GO:0043094)2.27776813
181deoxyribonucleotide metabolic process (GO:0009262)2.27668648
182establishment of protein localization to mitochondrion (GO:0072655)2.26370590
183positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.25886775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.09110076
2EZH2_22144423_ChIP-Seq_EOC_Human3.97227288
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.26023365
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09778897
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96879331
6SCL_19346495_ChIP-Seq_HPC-7_Human2.93782128
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.89179819
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.87964984
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.76096715
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54017475
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.52671834
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45470853
13IGF1R_20145208_ChIP-Seq_DFB_Human2.42815858
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.40576083
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.33436580
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31736432
17* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27701849
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21635131
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11570570
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09716565
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08803970
22TAF15_26573619_Chip-Seq_HEK293_Human2.07885411
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.07556937
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07533481
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06577154
26VDR_21846776_ChIP-Seq_THP-1_Human2.04955342
27IRF1_19129219_ChIP-ChIP_H3396_Human2.02239187
28GBX2_23144817_ChIP-Seq_PC3_Human1.99978823
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.93209698
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92549175
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90903241
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88687049
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.88496100
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84751560
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78280437
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77844812
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75219456
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73583038
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.71999971
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67120026
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66722961
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66405705
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66213370
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63097877
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62367005
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.59708395
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59280525
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58064568
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56823784
50* NFE2_27457419_Chip-Seq_LIVER_Mouse1.56502491
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56412503
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54659056
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.52648304
54VDR_24763502_ChIP-Seq_THP-1_Human1.50269871
55BCL6_27268052_Chip-Seq_Bcells_Human1.49355914
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48876519
57LXR_22292898_ChIP-Seq_THP-1_Human1.48581908
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48331823
59* EZH2_27294783_Chip-Seq_NPCs_Mouse1.46970573
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41142836
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41002782
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39200166
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39063823
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.38125361
65* ELK3_25401928_ChIP-Seq_HUVEC_Human1.37463741
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36994152
67GATA1_22025678_ChIP-Seq_K562_Human1.35499468
68* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35470823
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35363997
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35146323
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.34954049
72ZNF263_19887448_ChIP-Seq_K562_Human1.33532788
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32698802
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.32507628
75GABP_19822575_ChIP-Seq_HepG2_Human1.30715399
76BCOR_27268052_Chip-Seq_Bcells_Human1.30409742
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.30381883
78SPI1_23547873_ChIP-Seq_NB4_Human1.29783282
79* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28964216
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28399875
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26483773
82* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25502467
83* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25181425
84* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25019968
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24180431
86* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23171568
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23168423
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.23120919
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22898559
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22611967
91* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22303705
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22157344
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22119973
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21789614
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.20882581
96TFEB_21752829_ChIP-Seq_HELA_Human1.20837512
97RNF2_27304074_Chip-Seq_NSC_Mouse1.20816640
98* P300_18555785_Chip-Seq_ESCs_Mouse1.20160319
99* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19664563
100DCP1A_22483619_ChIP-Seq_HELA_Human1.19402949
101* P53_22387025_ChIP-Seq_ESCs_Mouse1.18987591
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18585954
103* STAT3_18555785_Chip-Seq_ESCs_Mouse1.17700076
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.16277658
105* NMYC_18555785_Chip-Seq_ESCs_Mouse1.15103342
106* IRF8_27001747_Chip-Seq_BMDM_Mouse1.14230294
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14068707
108* FOXP3_21729870_ChIP-Seq_TREG_Human1.12279996
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12260608
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11822882
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.11339204
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10685926
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10586007
114NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10385765
115MYC_18940864_ChIP-ChIP_HL60_Human1.10134433
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09448106
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08105149
118P68_20966046_ChIP-Seq_HELA_Human1.07591039
119STAT1_20625510_ChIP-Seq_HELA_Human1.06833140
120* NANOG_18555785_Chip-Seq_ESCs_Mouse1.06698331
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06384935
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06330384
123MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06034456
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05440138
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05333480
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04554674
127EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03790207
128XRN2_22483619_ChIP-Seq_HELA_Human1.03387220
129IRF8_21731497_ChIP-ChIP_J774_Mouse1.03201447
130FUS_26573619_Chip-Seq_HEK293_Human1.03034910
131STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02345116
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02160560
133* OCT4_18555785_Chip-Seq_ESCs_Mouse1.01880604
134* CRX_20693478_ChIP-Seq_RETINA_Mouse1.01752189
135* ZFX_18555785_Chip-Seq_ESCs_Mouse1.01670332
136* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01564739
137HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01429331
138MAF_26560356_Chip-Seq_TH1_Human1.01415624
139YY1_21170310_ChIP-Seq_MESCs_Mouse1.01157112
140VDR_23849224_ChIP-Seq_CD4+_Human1.00668095
141* KLF4_18555785_Chip-Seq_ESCs_Mouse0.99454366
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98831525
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98648988
144EED_16625203_ChIP-ChIP_MESCs_Mouse0.98068986
145* SOX2_18555785_Chip-Seq_ESCs_Mouse0.97820901
146* CMYC_18555785_Chip-Seq_ESCs_Mouse0.97357708
147* E2F1_18555785_Chip-Seq_ESCs_Mouse0.97297677
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96617455
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93980658
150LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93652134
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93409442
152* PU1_27457419_Chip-Seq_LIVER_Mouse0.92939708
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92536053
154POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92115120
155* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91334894
156ER_23166858_ChIP-Seq_MCF-7_Human0.91240353
157ETS1_20019798_ChIP-Seq_JURKAT_Human0.90981896
158* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90878519
159SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90447527
160JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89964854
161P300_19829295_ChIP-Seq_ESCs_Human0.89940233
162SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89144133
163* CTCF_18555785_Chip-Seq_ESCs_Mouse0.88306628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.92906436
2MP0009379_abnormal_foot_pigmentation4.91791153
3MP0003136_yellow_coat_color4.51657046
4MP0005409_darkened_coat_color4.48111821
5MP0001188_hyperpigmentation4.04788855
6MP0005058_abnormal_lysosome_morphology3.93917079
7MP0005174_abnormal_tail_pigmentation3.52810347
8MP0006292_abnormal_olfactory_placode3.52493633
9MP0004381_abnormal_hair_follicle3.49934471
10MP0003724_increased_susceptibility_to3.22977530
11MP0009840_abnormal_foam_cell3.10822225
12MP0000015_abnormal_ear_pigmentation2.84139429
13MP0005075_abnormal_melanosome_morpholog2.73277470
14MP0002139_abnormal_hepatobiliary_system2.72604019
15MP0003191_abnormal_cellular_cholesterol2.68803458
16MP0003186_abnormal_redox_activity2.67930104
17MP0001986_abnormal_taste_sensitivity2.38201418
18MP0006082_CNS_inflammation2.21327151
19MP0002095_abnormal_skin_pigmentation2.15174995
20MP0003880_abnormal_central_pattern2.13135704
21MP0003075_altered_response_to2.08916373
22MP0005451_abnormal_body_composition2.06137601
23MP0000372_irregular_coat_pigmentation2.04463486
24MP0006036_abnormal_mitochondrial_physio2.00485460
25MP0009785_altered_susceptibility_to1.98236105
26MP0000343_altered_response_to1.96686203
27MP0001835_abnormal_antigen_presentation1.90417124
28MP0005671_abnormal_response_to1.88201006
29MP0002148_abnormal_hypersensitivity_rea1.82263269
30MP0003172_abnormal_lysosome_physiology1.80588621
31MP0004147_increased_porphyrin_level1.72523863
32MP0001545_abnormal_hematopoietic_system1.68343857
33MP0005397_hematopoietic_system_phenotyp1.68343857
34MP0004142_abnormal_muscle_tone1.62553157
35MP0001533_abnormal_skeleton_physiology1.60542234
36MP0005365_abnormal_bile_salt1.59826815
37MP0005165_increased_susceptibility_to1.57882925
38MP0000685_abnormal_immune_system1.57836209
39MP0005025_abnormal_response_to1.57751393
40MP0002009_preneoplasia1.57189333
41MP0002876_abnormal_thyroid_physiology1.54296757
42MP0002396_abnormal_hematopoietic_system1.52901396
43MP0001845_abnormal_inflammatory_respons1.50946127
44MP0008260_abnormal_autophagy1.49427028
45MP0005360_urolithiasis1.49167902
46MP0009278_abnormal_bone_marrow1.45117152
47MP0000681_abnormal_thyroid_gland1.43477590
48MP0008875_abnormal_xenobiotic_pharmacok1.39820650
49MP0000465_gastrointestinal_hemorrhage1.39250410
50MP0005000_abnormal_immune_tolerance1.38997462
51MP0002138_abnormal_hepatobiliary_system1.38461140
52MP0002102_abnormal_ear_morphology1.34634045
53MP0002177_abnormal_outer_ear1.33904640
54MP0000858_altered_metastatic_potential1.33551923
55MP0004145_abnormal_muscle_electrophysio1.32413960
56MP0005670_abnormal_white_adipose1.31506041
57MP0001905_abnormal_dopamine_level1.29905965
58MP0005166_decreased_susceptibility_to1.26934714
59MP0002419_abnormal_innate_immunity1.26563865
60MP0000490_abnormal_crypts_of1.25982819
61MP0002723_abnormal_immune_serum1.25372088
62MP0005319_abnormal_enzyme/_coenzyme1.21468681
63MP0000566_synostosis1.18846399
64MP0002938_white_spotting1.17865897
65MP0005171_absent_coat_pigmentation1.17046464
66MP0000049_abnormal_middle_ear1.17030002
67MP0003938_abnormal_ear_development1.15271762
68MP0003436_decreased_susceptibility_to1.13983679
69MP0001853_heart_inflammation1.13516981
70MP0003763_abnormal_thymus_physiology1.13449319
71MP0001800_abnormal_humoral_immune1.12589546
72MP0005379_endocrine/exocrine_gland_phen1.12337238
73MP0002420_abnormal_adaptive_immunity1.12159078
74MP0002277_abnormal_respiratory_mucosa1.11455960
75MP0009763_increased_sensitivity_to1.09746191
76MP0001819_abnormal_immune_cell1.09681091
77MP0005084_abnormal_gallbladder_morpholo1.09537628
78MP0001764_abnormal_homeostasis1.09035884
79MP0002452_abnormal_antigen_presenting1.07474821
80MP0009333_abnormal_splenocyte_physiolog1.05614898
81MP0000920_abnormal_myelination1.03821933
82MP0001790_abnormal_immune_system1.02557313
83MP0005387_immune_system_phenotype1.02557313
84MP0001542_abnormal_bone_strength1.02476759
85MP0009643_abnormal_urine_homeostasis1.01764329
86MP0006035_abnormal_mitochondrial_morpho1.01031978
87MP0004742_abnormal_vestibular_system0.99675783
88MP0005584_abnormal_enzyme/coenzyme_acti0.99662530
89MP0005332_abnormal_amino_acid0.99431686
90MP0003195_calcinosis0.98530134
91MP0003656_abnormal_erythrocyte_physiolo0.98187873
92MP0005464_abnormal_platelet_physiology0.98112826
93MP0002638_abnormal_pupillary_reflex0.97976344
94MP0000613_abnormal_salivary_gland0.97206460
95MP0009697_abnormal_copulation0.94290948
96MP0002751_abnormal_autonomic_nervous0.94040387
97MP0000604_amyloidosis0.93495872
98MP0000631_abnormal_neuroendocrine_gland0.93128198
99MP0003011_delayed_dark_adaptation0.92412102
100MP0008058_abnormal_DNA_repair0.92225585
101MP0002166_altered_tumor_susceptibility0.90973850
102MP0003868_abnormal_feces_composition0.90864693
103MP0004019_abnormal_vitamin_homeostasis0.90521608
104MP0004510_myositis0.90413102
105MP0003448_altered_tumor_morphology0.90033418
106MP0006276_abnormal_autonomic_nervous0.89524158
107MP0005085_abnormal_gallbladder_physiolo0.88899483
108MP0002249_abnormal_larynx_morphology0.88258447
109MP0000358_abnormal_cell_content/0.87169521
110MP0002254_reproductive_system_inflammat0.87014949
111MP0000716_abnormal_immune_system0.85927427
112MP0000609_abnormal_liver_physiology0.84190963
113MP0003866_abnormal_defecation0.84189369
114MP0002398_abnormal_bone_marrow0.83221971
115MP0003638_abnormal_response/metabolism_0.83218322
116MP0008873_increased_physiological_sensi0.82495104
117MP0001963_abnormal_hearing_physiology0.81812462
118MP0002132_abnormal_respiratory_system0.80932578
119MP0005390_skeleton_phenotype0.80632914
120MP0004947_skin_inflammation0.80348215
121MP0000026_abnormal_inner_ear0.80283927
122MP0002933_joint_inflammation0.80168607
123MP0002998_abnormal_bone_remodeling0.79705216
124MP0001663_abnormal_digestive_system0.78877044
125MP0001881_abnormal_mammary_gland0.78874365
126MP0005023_abnormal_wound_healing0.78355912
127MP0002006_tumorigenesis0.78140472
128MP0010155_abnormal_intestine_physiology0.77917616
129MP0009765_abnormal_xenobiotic_induced0.77555344
130MP0003879_abnormal_hair_cell0.77545770
131MP0000689_abnormal_spleen_morphology0.77178699
132MP0001486_abnormal_startle_reflex0.77105941
133MP0003303_peritoneal_inflammation0.76973675
134MP0005410_abnormal_fertilization0.76906051
135MP0005636_abnormal_mineral_homeostasis0.76898879
136MP0005164_abnormal_response_to0.76816642
137MP0008469_abnormal_protein_level0.75812258
138MP0002272_abnormal_nervous_system0.75391798
139MP0001873_stomach_inflammation0.70317650
140MP0002722_abnormal_immune_system0.67448226
141MP0002067_abnormal_sensory_capabilities0.67395471
142MP0002429_abnormal_blood_cell0.66186606
143MP0003828_pulmonary_edema0.65417309
144MP0002405_respiratory_system_inflammati0.65295925
145MP0001968_abnormal_touch/_nociception0.64687002
146MP0003315_abnormal_perineum_morphology0.64218906
147MP0005423_abnormal_somatic_nervous0.63669940
148MP0008569_lethality_at_weaning0.63569752
149MP0009764_decreased_sensitivity_to0.63069744
150MP0003646_muscle_fatigue0.62826612
151MP0001661_extended_life_span0.62167172
152MP0005408_hypopigmentation0.61726545
153MP0004270_analgesia0.61416108
154MP0003718_maternal_effect0.60169776

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)5.27900852
2Abnormality of glycolipid metabolism (HP:0010969)5.06722354
3Abnormality of liposaccharide metabolism (HP:0010968)5.06722354
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.06722354
5Nonprogressive disorder (HP:0003680)5.04530626
6Reduced antithrombin III activity (HP:0001976)4.87373401
7Abnormality of the axillary hair (HP:0100134)4.24808140
8Abnormality of secondary sexual hair (HP:0009888)4.24808140
9Hypothermia (HP:0002045)4.02483673
10Systemic lupus erythematosus (HP:0002725)4.00498605
11Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.68108906
12Abnormal protein N-linked glycosylation (HP:0012347)3.68108906
13Abnormal protein glycosylation (HP:0012346)3.68108906
14Abnormal glycosylation (HP:0012345)3.68108906
15Abnormality of cells of the erythroid lineage (HP:0012130)3.65816252
16Abnormal number of erythroid precursors (HP:0012131)3.65041772
17Abnormal mitochondria in muscle tissue (HP:0008316)3.62068150
18Vacuolated lymphocytes (HP:0001922)3.45799439
193-Methylglutaconic aciduria (HP:0003535)3.42072399
20Acute encephalopathy (HP:0006846)3.34613208
21Thyroid-stimulating hormone excess (HP:0002925)3.27622306
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.25082428
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.22421585
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19457537
25Absent rod-and cone-mediated responses on ERG (HP:0007688)3.18604986
26Increased cerebral lipofuscin (HP:0011813)3.18412651
27Aplastic anemia (HP:0001915)3.16941446
28Type 2 muscle fiber atrophy (HP:0003554)3.15652401
29Increased hepatocellular lipid droplets (HP:0006565)3.08530759
30Renal Fanconi syndrome (HP:0001994)3.03927549
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.02692342
32Hepatocellular necrosis (HP:0001404)2.99048340
33Dysostosis multiplex (HP:0000943)2.92453419
34Purpura (HP:0000979)2.89433192
35Reticulocytopenia (HP:0001896)2.86795341
36Progressive macrocephaly (HP:0004481)2.85877534
37Prolonged neonatal jaundice (HP:0006579)2.82351755
38Muscle fiber atrophy (HP:0100295)2.80121519
39Severe visual impairment (HP:0001141)2.78561091
40Amyloidosis (HP:0011034)2.77999986
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72812036
42Peripheral hypomyelination (HP:0007182)2.71001252
43Hepatosplenomegaly (HP:0001433)2.68922809
44Progressive neurologic deterioration (HP:0002344)2.66345211
45Attenuation of retinal blood vessels (HP:0007843)2.59592147
46Cerebral edema (HP:0002181)2.56969500
47Lipid accumulation in hepatocytes (HP:0006561)2.56822278
48Exertional dyspnea (HP:0002875)2.56753023
49Increased serum ferritin (HP:0003281)2.56407130
50Loss of speech (HP:0002371)2.51652367
51Complement deficiency (HP:0004431)2.50685863
52Parakeratosis (HP:0001036)2.48897602
53Vertebral compression fractures (HP:0002953)2.48734465
54Progressive inability to walk (HP:0002505)2.47384363
55Mitochondrial inheritance (HP:0001427)2.45880642
56Microvesicular hepatic steatosis (HP:0001414)2.44747137
57Hepatic necrosis (HP:0002605)2.43510766
58Abnormality of polysaccharide metabolism (HP:0011012)2.43124120
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43124120
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43124120
61Mediastinal lymphadenopathy (HP:0100721)2.42745924
62Respiratory failure (HP:0002878)2.41214301
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40552947
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40552947
65Elevated erythrocyte sedimentation rate (HP:0003565)2.40500838
66Abnormality of complement system (HP:0005339)2.39460010
67Macrocytic anemia (HP:0001972)2.38781036
68Abnormality of magnesium homeostasis (HP:0004921)2.38362406
69Lactic acidosis (HP:0003128)2.34505826
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.32094239
71Patchy hypopigmentation of hair (HP:0011365)2.31661617
72True hermaphroditism (HP:0010459)2.26732478
73Optic disc pallor (HP:0000543)2.24917529
74Recurrent bacterial skin infections (HP:0005406)2.23775876
75Increased intramyocellular lipid droplets (HP:0012240)2.23004474
76Myositis (HP:0100614)2.22687869
77Rough bone trabeculation (HP:0100670)2.21080201
78Recurrent gram-negative bacterial infections (HP:0005420)2.20060977
79Dry hair (HP:0011359)2.19393985
80Sex reversal (HP:0012245)2.17968392
81Abnormal sex determination (HP:0012244)2.17968392
82Abnormal rod and cone electroretinograms (HP:0008323)2.17956761
83Pallor (HP:0000980)2.17822783
84Meningitis (HP:0001287)2.16485261
85Stomatitis (HP:0010280)2.16285932
86Abnormality of iron homeostasis (HP:0011031)2.16235036
87Glomerulonephritis (HP:0000099)2.14654247
88Mucopolysacchariduria (HP:0008155)2.14475066
89Urinary glycosaminoglycan excretion (HP:0003541)2.14475066
90Cerebral palsy (HP:0100021)2.14044374
91Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12884679
92Retinal dysplasia (HP:0007973)2.12516831
93Flat occiput (HP:0005469)2.11915542
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.09414381
95Absent/shortened dynein arms (HP:0200106)2.09414381
96Prolonged partial thromboplastin time (HP:0003645)2.08965742
97Petechiae (HP:0000967)2.05582479
98Abnormality of the heme biosynthetic pathway (HP:0010472)2.05520121
99Dicarboxylic aciduria (HP:0003215)2.03325801
100Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03325801
101Prolonged bleeding time (HP:0003010)2.03291145
102Abnormal ciliary motility (HP:0012262)2.03105962
103Axonal loss (HP:0003447)2.02611946
104White forelock (HP:0002211)2.02598591
105Hyperammonemia (HP:0001987)2.02384469
106Exercise intolerance (HP:0003546)2.02171392
107Recurrent abscess formation (HP:0002722)2.01822210
108Distal lower limb muscle weakness (HP:0009053)2.01261495
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99966265
110Generalized aminoaciduria (HP:0002909)1.99961214
111Nausea (HP:0002018)1.98741978
112Hypertensive crisis (HP:0100735)1.98347726
113Thrombocytosis (HP:0001894)1.97001931
114Increased IgM level (HP:0003496)1.95998894
115Microcytic anemia (HP:0001935)1.95903962
116Obstructive lung disease (HP:0006536)1.95657404
117Chronic obstructive pulmonary disease (HP:0006510)1.95657404
118Lethargy (HP:0001254)1.95504773
119IgM deficiency (HP:0002850)1.94993747
120Increased CSF lactate (HP:0002490)1.93996722
121Abnormality of the prostate (HP:0008775)1.93988424
122Pancytopenia (HP:0001876)1.93046975
123Abnormality of renal resorption (HP:0011038)1.91761788
124Nuclear cataract (HP:0100018)1.90977588
125Abnormal respiratory epithelium morphology (HP:0012253)1.89606457
126Abnormal respiratory motile cilium morphology (HP:0005938)1.89606457
127Acute necrotizing encephalopathy (HP:0006965)1.87496514
128Agammaglobulinemia (HP:0004432)1.85995913
129Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85306375
130Abnormal trabecular bone morphology (HP:0100671)1.85020092
131Skin rash (HP:0000988)1.84222384
132Ulnar claw (HP:0001178)1.83851063
133Weak cry (HP:0001612)1.83513522
134Aplasia/hypoplasia of the uterus (HP:0008684)1.83306858
135Hypomagnesemia (HP:0002917)1.82797638
136Abnormality of the columella (HP:0009929)1.81960466
137Abnormal respiratory motile cilium physiology (HP:0012261)1.80112692
138Epistaxis (HP:0000421)1.79292163
139Pulmonary infiltrates (HP:0002113)1.79011337
140Beaking of vertebral bodies (HP:0004568)1.78717801
141Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78597664
142Eczematoid dermatitis (HP:0000976)1.77809497
143Abnormality of transition element cation homeostasis (HP:0011030)1.76943974
144Oral leukoplakia (HP:0002745)1.76407677
145Respiratory difficulties (HP:0002880)1.76189022
146CNS demyelination (HP:0007305)1.76144318
147Autoimmune thrombocytopenia (HP:0001973)1.75426233
148Increased muscle lipid content (HP:0009058)1.75386498
149Split foot (HP:0001839)1.75271320
150Hypokinesia (HP:0002375)1.74175769
151Abnormality of macrophages (HP:0004311)1.73945690
152Increased serum lactate (HP:0002151)1.73046857
153Anhidrosis (HP:0000970)1.72022091
154Keratoconus (HP:0000563)1.71315666
155Increased corneal curvature (HP:0100692)1.71315666
156Asplenia (HP:0001746)1.70309605
157Renal tubular dysfunction (HP:0000124)1.68956430
158Gonadal dysgenesis (HP:0000133)1.68935404
159Decreased central vision (HP:0007663)1.67132338
160Cortical visual impairment (HP:0100704)1.66583135
161Pancreatic cysts (HP:0001737)1.66283263
162Retrobulbar optic neuritis (HP:0100654)1.64297654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.29704107
2MUSK5.41040943
3VRK24.14376116
4CASK4.09220475
5STK163.58946163
6TESK23.45015855
7MKNK22.90520436
8TESK12.88012961
9ERN12.64762262
10SRPK12.51816106
11NME22.49773445
12BCKDK2.32728577
13EIF2AK32.32684208
14NLK2.31114060
15ABL22.26716856
16MAP3K112.19720121
17ARAF2.08072198
18CDK191.95224916
19MKNK11.94468800
20FES1.90229420
21KIT1.83340858
22TEC1.78271077
23IRAK41.76710985
24TLK11.70473532
25SCYL21.67016363
26IRAK31.62224847
27MAP3K31.47137831
28TYK21.41817100
29LIMK11.41268985
30EIF2AK21.37636336
31TAOK21.36274888
32ADRBK21.35708503
33BUB11.35470702
34BLK1.35184772
35TXK1.30412457
36CAMKK21.25978067
37MAP3K121.25361850
38MAP2K31.24517824
39VRK11.23746948
40MAPKAPK51.21482690
41PAK41.16789531
42BMPR1B1.16577671
43DAPK11.16014613
44BTK1.15654649
45MAP2K71.14492398
46MAPKAPK31.14090033
47PIM21.12203371
48IRAK11.11003454
49IRAK21.10997495
50WEE11.07951983
51YES11.06995117
52ILK1.06166407
53STK391.05508085
54CAMK11.04012661
55PDK21.04002734
56MAPK151.03318774
57EPHA21.01685712
58MST1R0.99533027
59GRK70.98283724
60GRK10.97935351
61CLK10.93233867
62OXSR10.93107057
63NEK60.92024118
64TIE10.91716654
65CSNK1G10.90210054
66MAP4K20.89450032
67IKBKE0.88816185
68JAK30.85855074
69MST40.83752758
70IKBKB0.83468620
71NEK10.81172992
72EIF2AK10.79186860
73MAP4K10.79030588
74LRRK20.77007231
75HIPK20.76700635
76PRKG20.75867440
77DAPK30.74438876
78LYN0.73363554
79MAP3K10.73076378
80MAP3K140.73057331
81KDR0.72182979
82PIK3CG0.71995413
83MAPK130.71995323
84PAK10.70850780
85MAP2K60.70342556
86TNK20.68067491
87FLT30.67092112
88CSF1R0.65869632
89GRK60.64968729
90MATK0.62812402
91CSNK1G30.61557356
92CDK30.59934390
93NME10.59845123
94SYK0.58384285
95MAPK40.58066762
96TGFBR20.56523528
97FGR0.56457515
98PRKD20.56455154
99MOS0.54971668
100TBK10.54608831
101TAOK30.54173572
102MYLK0.53866234
103AURKA0.53584021
104LCK0.52759328
105EPHB20.52266181
106CAMK2B0.51549991
107RPS6KA50.48654907
108GRK50.47055152
109DYRK30.45997743
110RIPK40.45953391
111DYRK20.45453636
112BMPR20.44739843
113STK100.43758863
114LMTK20.43397130
115PRPF4B0.42034473
116PRKCD0.41663747
117ITK0.40735435
118MAP3K80.39066550
119PHKG10.38497121
120PHKG20.38497121
121PKN10.38293780
122CDK70.38147670
123PBK0.38137434
124MAPKAPK20.37059978
125CSNK1A1L0.36665155
126UHMK10.36642296
127PRKAA20.36453227
128BRAF0.35959747
129SMG10.35792034
130HCK0.33842206
131MAP3K60.33069553
132CAMK2D0.32966487
133PTK2B0.31715206
134CAMK2G0.31452157
135PINK10.29818042
136ZAP700.28660753
137CSNK2A10.28264159
138CSK0.28176582
139PIM10.27969830
140ACVR1B0.26792739
141CDK80.26677706
142INSRR0.25345029
143PRKG10.25106818
144NUAK10.24853319
145BRSK20.24454578
146BRD40.23919904
147CSNK2A20.23894304
148CSNK1G20.22777824

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.50358720
2Protein export_Homo sapiens_hsa030603.55464403
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.64705332
4DNA replication_Homo sapiens_hsa030302.52861011
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.51183938
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.46341159
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37245011
8Homologous recombination_Homo sapiens_hsa034402.25684306
9RNA polymerase_Homo sapiens_hsa030202.18712685
10Staphylococcus aureus infection_Homo sapiens_hsa051502.13627984
11Oxidative phosphorylation_Homo sapiens_hsa001902.07178988
12Lysosome_Homo sapiens_hsa041421.77276934
13Pyrimidine metabolism_Homo sapiens_hsa002401.75917943
14Other glycan degradation_Homo sapiens_hsa005111.74885775
15Sphingolipid metabolism_Homo sapiens_hsa006001.68969433
16Fanconi anemia pathway_Homo sapiens_hsa034601.66989580
17Fatty acid elongation_Homo sapiens_hsa000621.66142766
18Antigen processing and presentation_Homo sapiens_hsa046121.60291016
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56527562
20Primary immunodeficiency_Homo sapiens_hsa053401.55713077
21Type I diabetes mellitus_Homo sapiens_hsa049401.54221717
22Parkinsons disease_Homo sapiens_hsa050121.53917757
23Non-homologous end-joining_Homo sapiens_hsa034501.50780512
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42996614
25Mismatch repair_Homo sapiens_hsa034301.41924156
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41426244
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.41161056
28Arachidonic acid metabolism_Homo sapiens_hsa005901.40500666
29Basal transcription factors_Homo sapiens_hsa030221.38283108
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37850997
31Sulfur relay system_Homo sapiens_hsa041221.36477179
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34269958
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30230367
34Folate biosynthesis_Homo sapiens_hsa007901.28409734
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28003722
36Galactose metabolism_Homo sapiens_hsa000521.27656106
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26750562
38Purine metabolism_Homo sapiens_hsa002301.25229187
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23835615
40Phototransduction_Homo sapiens_hsa047441.22737266
41Ether lipid metabolism_Homo sapiens_hsa005651.22643325
42Pentose phosphate pathway_Homo sapiens_hsa000301.22498591
43Nucleotide excision repair_Homo sapiens_hsa034201.22433737
44N-Glycan biosynthesis_Homo sapiens_hsa005101.22032755
45Allograft rejection_Homo sapiens_hsa053301.21887182
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21166976
47Proteasome_Homo sapiens_hsa030501.20843410
48Malaria_Homo sapiens_hsa051441.18391993
49Base excision repair_Homo sapiens_hsa034101.16865067
50Hematopoietic cell lineage_Homo sapiens_hsa046401.16791241
51Alzheimers disease_Homo sapiens_hsa050101.15713326
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12528572
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.10996774
54Complement and coagulation cascades_Homo sapiens_hsa046101.10856718
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09696623
56Huntingtons disease_Homo sapiens_hsa050161.09138409
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09132058
58Chemical carcinogenesis_Homo sapiens_hsa052041.08536649
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.08366667
60Phenylalanine metabolism_Homo sapiens_hsa003601.07699406
61Asthma_Homo sapiens_hsa053101.07330012
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04733036
63Viral myocarditis_Homo sapiens_hsa054161.01219150
64Spliceosome_Homo sapiens_hsa030401.00092260
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.99305117
66Tyrosine metabolism_Homo sapiens_hsa003500.99218036
67Measles_Homo sapiens_hsa051620.94255878
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93779070
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93440407
70Fructose and mannose metabolism_Homo sapiens_hsa000510.90492125
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.89147440
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89002754
73Tuberculosis_Homo sapiens_hsa051520.87933143
74Carbon metabolism_Homo sapiens_hsa012000.87864835
75Collecting duct acid secretion_Homo sapiens_hsa049660.87029824
76Salmonella infection_Homo sapiens_hsa051320.86936223
77Phagosome_Homo sapiens_hsa041450.84815975
78Shigellosis_Homo sapiens_hsa051310.84750255
79Graft-versus-host disease_Homo sapiens_hsa053320.83295821
80Autoimmune thyroid disease_Homo sapiens_hsa053200.83089787
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.82474592
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77799254
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.77429408
84Histidine metabolism_Homo sapiens_hsa003400.77396755
85RNA degradation_Homo sapiens_hsa030180.76996672
86Legionellosis_Homo sapiens_hsa051340.76772229
87Linoleic acid metabolism_Homo sapiens_hsa005910.76613360
88Herpes simplex infection_Homo sapiens_hsa051680.76153733
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.75253009
90Biosynthesis of amino acids_Homo sapiens_hsa012300.74670528
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74383080
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71873966
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70730859
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69977407
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.69823990
96Pyruvate metabolism_Homo sapiens_hsa006200.67830167
97Leishmaniasis_Homo sapiens_hsa051400.67821058
98Vibrio cholerae infection_Homo sapiens_hsa051100.65939775
99Pertussis_Homo sapiens_hsa051330.64546613
100Metabolic pathways_Homo sapiens_hsa011000.64169655
101Rheumatoid arthritis_Homo sapiens_hsa053230.63740190
102ABC transporters_Homo sapiens_hsa020100.62257109
103Thyroid cancer_Homo sapiens_hsa052160.60440109
104Fatty acid degradation_Homo sapiens_hsa000710.58274873
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57619840
106Steroid biosynthesis_Homo sapiens_hsa001000.57454383
107Serotonergic synapse_Homo sapiens_hsa047260.56742725
108Nicotine addiction_Homo sapiens_hsa050330.56596693
109Retinol metabolism_Homo sapiens_hsa008300.55468787
110Tryptophan metabolism_Homo sapiens_hsa003800.53241421
111African trypanosomiasis_Homo sapiens_hsa051430.52297104
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51664446
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51610444
114B cell receptor signaling pathway_Homo sapiens_hsa046620.51212218
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49851307
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49037862
117Glutathione metabolism_Homo sapiens_hsa004800.48701525
118Vitamin digestion and absorption_Homo sapiens_hsa049770.47185306
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46507453
120Sulfur metabolism_Homo sapiens_hsa009200.45817727
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45229841
122Influenza A_Homo sapiens_hsa051640.44487758
123Arginine biosynthesis_Homo sapiens_hsa002200.43237858
124Toxoplasmosis_Homo sapiens_hsa051450.43230273
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42358678
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42335673
127Epstein-Barr virus infection_Homo sapiens_hsa051690.41727490
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41718748
129Taste transduction_Homo sapiens_hsa047420.40641793
130Systemic lupus erythematosus_Homo sapiens_hsa053220.40563524
131Regulation of autophagy_Homo sapiens_hsa041400.40437308
132Acute myeloid leukemia_Homo sapiens_hsa052210.39414071
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32336638
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30142327
135Long-term depression_Homo sapiens_hsa047300.28413446
136Calcium signaling pathway_Homo sapiens_hsa040200.27611348
137Peroxisome_Homo sapiens_hsa041460.26231149
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.24360911
139Morphine addiction_Homo sapiens_hsa050320.23493717
140Platelet activation_Homo sapiens_hsa046110.22819563
141Osteoclast differentiation_Homo sapiens_hsa043800.21981728

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