DUSP26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)7.88435196
2muscle filament sliding (GO:0030049)7.72728016
3actin-myosin filament sliding (GO:0033275)7.72728016
4actin-mediated cell contraction (GO:0070252)6.27233920
5skeletal muscle contraction (GO:0003009)6.02473488
6regulation of skeletal muscle contraction (GO:0014819)6.01758028
7regulation of relaxation of muscle (GO:1901077)5.35495130
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.34837301
9striated muscle contraction (GO:0006941)5.11871226
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.09527727
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06682419
12myofibril assembly (GO:0030239)4.98808074
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.98345557
14synaptic vesicle maturation (GO:0016188)4.92706892
15creatine metabolic process (GO:0006600)4.88632634
16synaptic vesicle exocytosis (GO:0016079)4.83043253
17actin filament-based movement (GO:0030048)4.63701245
18neuron cell-cell adhesion (GO:0007158)4.63623218
19regulation of synaptic vesicle exocytosis (GO:2000300)4.53053354
20regulation of cell communication by electrical coupling (GO:0010649)4.43293340
21glutamate secretion (GO:0014047)4.40787963
22sarcomere organization (GO:0045214)4.40356596
23neuronal action potential propagation (GO:0019227)4.39315665
24response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.39144968
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.29798347
26protein localization to synapse (GO:0035418)4.26505961
27response to muscle activity (GO:0014850)4.25267783
28cardiac muscle contraction (GO:0060048)4.21676775
29vocalization behavior (GO:0071625)4.16420790
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09239103
31cardiac myofibril assembly (GO:0055003)4.08406971
32response to inactivity (GO:0014854)4.05771755
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.04992477
34skeletal muscle fiber development (GO:0048741)4.03175989
35regulation of actin filament-based movement (GO:1903115)4.01028870
36regulation of synaptic vesicle transport (GO:1902803)3.98010853
37muscle contraction (GO:0006936)3.88678885
38neurotransmitter secretion (GO:0007269)3.85034741
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.83353989
40central nervous system myelination (GO:0022010)3.81306345
41axon ensheathment in central nervous system (GO:0032291)3.81306345
42locomotory exploration behavior (GO:0035641)3.74553105
43regulation of glutamate receptor signaling pathway (GO:1900449)3.70544441
44regulation of membrane repolarization (GO:0060306)3.69815653
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.68865336
46myotube cell development (GO:0014904)3.65264131
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.65127777
48regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.57767836
49plasma membrane repair (GO:0001778)3.56625498
50positive regulation of synapse maturation (GO:0090129)3.55790444
51cardiac muscle hypertrophy (GO:0003300)3.53510327
52muscle fiber development (GO:0048747)3.53303825
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.52460478
54neuromuscular process controlling posture (GO:0050884)3.52320692
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.49297678
56muscle system process (GO:0003012)3.48518176
57ionotropic glutamate receptor signaling pathway (GO:0035235)3.47673989
58neuron-neuron synaptic transmission (GO:0007270)3.47651219
59negative regulation of calcium ion transmembrane transport (GO:1903170)3.47018160
60negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.47018160
61layer formation in cerebral cortex (GO:0021819)3.45190882
62neurotransmitter transport (GO:0006836)3.42655300
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42317560
64regulation of calcium ion transmembrane transporter activity (GO:1901019)3.42267662
65regulation of calcium ion transmembrane transport (GO:1903169)3.42267662
66glycine transport (GO:0015816)3.40554905
67synaptic transmission, glutamatergic (GO:0035249)3.39740218
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.38993015
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37855499
70proline transport (GO:0015824)3.36494705
71regulation of neuronal synaptic plasticity (GO:0048168)3.36212786
72striated muscle hypertrophy (GO:0014897)3.35865017
73negative regulation of microtubule polymerization (GO:0031115)3.35433503
74neuron recognition (GO:0008038)3.35392776
75actomyosin structure organization (GO:0031032)3.31521657
76cell migration in hindbrain (GO:0021535)3.31091832
77negative regulation of potassium ion transmembrane transport (GO:1901380)3.28540172
78regulation of synapse structural plasticity (GO:0051823)3.28284794
79glycogen catabolic process (GO:0005980)3.26884451
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26205983
81gamma-aminobutyric acid transport (GO:0015812)3.24485489
82transmission of nerve impulse (GO:0019226)3.23170933
83prepulse inhibition (GO:0060134)3.22941576
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20410867
85exploration behavior (GO:0035640)3.19632410
86positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.19550861
87regulation of vesicle fusion (GO:0031338)3.19545980
88synaptic vesicle docking involved in exocytosis (GO:0016081)3.19343599
89presynaptic membrane assembly (GO:0097105)3.18609055
90presynaptic membrane organization (GO:0097090)3.18260249
91mating behavior (GO:0007617)3.17734362
92glutamate receptor signaling pathway (GO:0007215)3.16517913
93adult walking behavior (GO:0007628)3.15566339
94neuronal action potential (GO:0019228)3.13675453
95membrane depolarization during action potential (GO:0086010)3.12301756
96detection of calcium ion (GO:0005513)3.11958556
97regulation of synapse maturation (GO:0090128)3.11397188
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11030337
99regulation of neurotransmitter secretion (GO:0046928)3.10781999
100regulation of striated muscle contraction (GO:0006942)3.09831123
101regulation of neurotransmitter levels (GO:0001505)3.09660236
102regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09533212
103cellular potassium ion homeostasis (GO:0030007)3.08815639
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07937013
105skeletal muscle adaptation (GO:0043501)3.07296102
106negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06543791
107potassium ion import (GO:0010107)3.05622708
108detection of temperature stimulus involved in sensory perception (GO:0050961)3.04316387
109detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.04316387
110dendritic spine morphogenesis (GO:0060997)3.02877295
111glucan catabolic process (GO:0009251)3.02851948
112regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02765094
113neuromuscular synaptic transmission (GO:0007274)3.01436294
114negative regulation of dendrite morphogenesis (GO:0050774)3.00651881
115membrane hyperpolarization (GO:0060081)3.00636051
116positive regulation of potassium ion transmembrane transport (GO:1901381)3.00582398
117striated muscle adaptation (GO:0014888)3.00239630
118neuronal ion channel clustering (GO:0045161)3.00122729
119regulation of neurotransmitter transport (GO:0051588)2.99579597
120establishment of mitochondrion localization (GO:0051654)2.99433119
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98598044
122activation of protein kinase A activity (GO:0034199)2.98522215
123behavioral response to cocaine (GO:0048148)2.96205966
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.96167345
125regulation of postsynaptic membrane potential (GO:0060078)2.95073981
126negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95033141
127long-term memory (GO:0007616)2.94051819
128positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.92694048
129gamma-aminobutyric acid signaling pathway (GO:0007214)2.91338952
130cardiac muscle adaptation (GO:0014887)2.91078046
131cardiac muscle hypertrophy in response to stress (GO:0014898)2.91078046
132muscle hypertrophy in response to stress (GO:0003299)2.91078046
133cerebellar Purkinje cell differentiation (GO:0021702)2.90969911
134muscle hypertrophy (GO:0014896)2.90883769
135axonal fasciculation (GO:0007413)2.89039045
136regulation of sodium ion transmembrane transporter activity (GO:2000649)2.88322103
137membrane depolarization (GO:0051899)2.87557241
138regulation of synaptic transmission, GABAergic (GO:0032228)2.87332082
139neurotransmitter-gated ion channel clustering (GO:0072578)2.86737801
140positive regulation of membrane potential (GO:0045838)2.86447386
141synapse assembly (GO:0007416)2.85860725
142regulation of sodium ion transmembrane transport (GO:1902305)2.85813799
143adult heart development (GO:0007512)2.85322475
144skeletal muscle tissue development (GO:0007519)2.83764437
145synaptic vesicle endocytosis (GO:0048488)2.83681917
146regulation of dopamine metabolic process (GO:0042053)2.83476541
147regulation of catecholamine metabolic process (GO:0042069)2.83476541
148regulation of glutamate secretion (GO:0014048)2.82171446
149calcium ion-dependent exocytosis (GO:0017156)2.81155982
150synaptic transmission, dopaminergic (GO:0001963)2.80531469
151response to auditory stimulus (GO:0010996)2.79900808
152postsynaptic membrane organization (GO:0001941)2.79615206
153neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77931866
154cellular polysaccharide catabolic process (GO:0044247)2.77711278
155vesicle transport along microtubule (GO:0047496)2.76904753
156positive regulation of sodium ion transport (GO:0010765)2.76386375
157regulation of voltage-gated calcium channel activity (GO:1901385)2.75987310
158positive regulation of cation channel activity (GO:2001259)2.75576125
159glucan biosynthetic process (GO:0009250)2.75534468
160glycogen biosynthetic process (GO:0005978)2.75534468
161dendrite morphogenesis (GO:0048813)2.75033348
162muscle cell cellular homeostasis (GO:0046716)2.74717705
163striatum development (GO:0021756)2.73969304
164dopamine receptor signaling pathway (GO:0007212)2.73855839
165adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73709972
166detection of temperature stimulus (GO:0016048)2.73262022
167auditory behavior (GO:0031223)2.73091783
168NADH metabolic process (GO:0006734)2.70758158
169potassium ion homeostasis (GO:0055075)2.68586036
170relaxation of muscle (GO:0090075)2.66813547
171behavioral response to nicotine (GO:0035095)2.66433015
172negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.66219434
173regulation of potassium ion transmembrane transporter activity (GO:1901016)2.65262463
174negative regulation of potassium ion transport (GO:0043267)2.64094364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29572230
2GBX2_23144817_ChIP-Seq_PC3_Human3.29881106
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10850867
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94378908
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89160062
6REST_21632747_ChIP-Seq_MESCs_Mouse2.72545862
7* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63703165
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59353639
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59353639
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.57922781
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55206576
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50664337
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49931100
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47182041
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43991679
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40656966
17* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33812138
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.31490657
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.31198194
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.24857399
21TAF15_26573619_Chip-Seq_HEK293_Human2.24202918
22* RARB_27405468_Chip-Seq_BRAIN_Mouse2.22260016
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10598495
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.04776947
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03048002
26DROSHA_22980978_ChIP-Seq_HELA_Human2.02631812
27AR_21572438_ChIP-Seq_LNCaP_Human1.80781869
28* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78165992
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77380999
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72994829
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67796547
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66243176
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62683353
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60321083
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.59006505
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52612893
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52067490
38SMAD4_21799915_ChIP-Seq_A2780_Human1.50301253
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45352447
40* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44107239
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43764235
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42411558
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41658138
44ZNF274_21170338_ChIP-Seq_K562_Hela1.40718374
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40654795
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.40624904
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.40586088
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38359027
49P300_19829295_ChIP-Seq_ESCs_Human1.38078042
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37410700
51VDR_22108803_ChIP-Seq_LS180_Human1.36769639
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35689844
53IGF1R_20145208_ChIP-Seq_DFB_Human1.33303190
54RNF2_27304074_Chip-Seq_NSC_Mouse1.28986682
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26559923
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25351556
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24418242
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.24181257
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23165331
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22934548
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22024248
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.18640428
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.18624295
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18169540
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13760444
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13749641
67AR_25329375_ChIP-Seq_VCAP_Human1.12453159
68STAT3_23295773_ChIP-Seq_U87_Human1.11647194
69* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11295225
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.10609710
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09927983
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08823674
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.05234630
74* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05077378
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04892861
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04716774
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04164092
78CTCF_27219007_Chip-Seq_Bcells_Human1.04133430
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03074229
80AR_19668381_ChIP-Seq_PC3_Human1.01975267
81RING1B_27294783_Chip-Seq_NPCs_Mouse0.98937823
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97525360
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97291811
84SMAD3_21741376_ChIP-Seq_ESCs_Human0.97067239
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95852773
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95792955
87* TCF4_23295773_ChIP-Seq_U87_Human0.94579157
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94232583
89ER_23166858_ChIP-Seq_MCF-7_Human0.93634387
90AHR_22903824_ChIP-Seq_MCF-7_Human0.92672451
91* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91676709
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.91395710
93RUNX2_22187159_ChIP-Seq_PCA_Human0.90771167
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90605197
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.88104537
96JUN_21703547_ChIP-Seq_K562_Human0.87374757
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87137133
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87092620
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.86782315
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.86782315
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.86630338
102* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86627015
103KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86063625
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85695597
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85543817
106MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85135021
107* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82906734
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82487008
109KDM2B_26808549_Chip-Seq_K562_Human0.81918899
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81176032
111CBP_20019798_ChIP-Seq_JUKART_Human0.81176032
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79749395
113OCT4_19829295_ChIP-Seq_ESCs_Human0.79481117
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.78666280
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78316132
116* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78071640
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77931157
118* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77028476
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.76360210
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76072540
121* OCT4_20526341_ChIP-Seq_ESCs_Human0.75606665
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.75382999
123HTT_18923047_ChIP-ChIP_STHdh_Human0.75167442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.08267697
2MP0003880_abnormal_central_pattern4.49821145
3MP0004859_abnormal_synaptic_plasticity4.47283776
4MP0004270_analgesia3.93216159
5MP0001968_abnormal_touch/_nociception3.70760250
6MP0003635_abnormal_synaptic_transmissio3.37563938
7MP0002734_abnormal_mechanical_nocicepti3.06177848
8MP0002735_abnormal_chemical_nociception2.98296220
9MP0006276_abnormal_autonomic_nervous2.97255114
10MP0009745_abnormal_behavioral_response2.94954378
11MP0002736_abnormal_nociception_after2.88879745
12MP0005423_abnormal_somatic_nervous2.84046925
13MP0002064_seizures2.83942658
14MP0002272_abnormal_nervous_system2.78775675
15MP0009046_muscle_twitch2.73315668
16MP0002106_abnormal_muscle_physiology2.70378154
17MP0002063_abnormal_learning/memory/cond2.67612604
18MP0002822_catalepsy2.65595153
19MP0002733_abnormal_thermal_nociception2.61321286
20MP0001970_abnormal_pain_threshold2.46066304
21MP0002572_abnormal_emotion/affect_behav2.44666284
22MP0004130_abnormal_muscle_cell2.35723452
23MP0004084_abnormal_cardiac_muscle2.32930649
24MP0001486_abnormal_startle_reflex2.32760193
25MP0002332_abnormal_exercise_endurance2.29993584
26MP0000759_abnormal_skeletal_muscle2.29935179
27MP0004087_abnormal_muscle_fiber2.28710596
28MP0005369_muscle_phenotype2.25245288
29MP0001529_abnormal_vocalization2.12240242
30MP0005620_abnormal_muscle_contractility2.11291322
31MP0002067_abnormal_sensory_capabilities2.05449165
32MP0001440_abnormal_grooming_behavior2.04465219
33MP0002269_muscular_atrophy2.02003171
34MP0001905_abnormal_dopamine_level1.96687614
35MP0000750_abnormal_muscle_regeneration1.89379789
36MP0002184_abnormal_innervation1.89310200
37MP0004215_abnormal_myocardial_fiber1.89012757
38MP0004858_abnormal_nervous_system1.87052805
39MP0001501_abnormal_sleep_pattern1.85216717
40MP0003122_maternal_imprinting1.81625223
41MP0000778_abnormal_nervous_system1.80708188
42MP0005386_behavior/neurological_phenoty1.79468391
43MP0004924_abnormal_behavior1.79468391
44MP0004142_abnormal_muscle_tone1.75072919
45MP0001986_abnormal_taste_sensitivity1.67863276
46MP0004233_abnormal_muscle_weight1.66102074
47MP0003329_amyloid_beta_deposits1.65771928
48MP0005330_cardiomyopathy1.62566977
49MP0008569_lethality_at_weaning1.61282500
50MP0004811_abnormal_neuron_physiology1.59330550
51MP0000955_abnormal_spinal_cord1.59161557
52MP0002557_abnormal_social/conspecific_i1.58635295
53MP0002972_abnormal_cardiac_muscle1.58264507
54MP0001984_abnormal_olfaction1.58158853
55MP0005646_abnormal_pituitary_gland1.55174194
56MP0000920_abnormal_myelination1.53301123
57MP0005645_abnormal_hypothalamus_physiol1.52782049
58MP0002882_abnormal_neuron_morphology1.51814007
59MP0005451_abnormal_body_composition1.48528150
60MP0004145_abnormal_muscle_electrophysio1.43181545
61MP0001502_abnormal_circadian_rhythm1.41663488
62MP0006036_abnormal_mitochondrial_physio1.41658089
63MP0002066_abnormal_motor_capabilities/c1.40979014
64MP0002909_abnormal_adrenal_gland1.38992426
65MP0004484_altered_response_of1.35033196
66MP0002229_neurodegeneration1.32637091
67MP0005551_abnormal_eye_electrophysiolog1.31282815
68MP0004885_abnormal_endolymph1.31159849
69MP0000751_myopathy1.30585939
70MP0004742_abnormal_vestibular_system1.28290998
71MP0003123_paternal_imprinting1.26353573
72MP0003633_abnormal_nervous_system1.24574286
73MP0002638_abnormal_pupillary_reflex1.20212579
74MP0003634_abnormal_glial_cell1.18518465
75MP0010386_abnormal_urinary_bladder1.15773892
76MP0009780_abnormal_chondrocyte_physiolo1.11808312
77MP0005266_abnormal_metabolism1.09762542
78MP0003631_nervous_system_phenotype1.07086944
79MP0003879_abnormal_hair_cell1.06924192
80MP0004510_myositis1.05442233
81MP0002108_abnormal_muscle_morphology1.04560081
82MP0008775_abnormal_heart_ventricle1.04173169
83MP0002752_abnormal_somatic_nervous1.02106316
84MP0002751_abnormal_autonomic_nervous1.01125041
85MP0000733_abnormal_muscle_development0.98660839
86MP0003121_genomic_imprinting0.98513140
87MP0008872_abnormal_physiological_respon0.97773095
88MP0005385_cardiovascular_system_phenoty0.97490849
89MP0001544_abnormal_cardiovascular_syste0.97490849
90MP0001188_hyperpigmentation0.95994904
91MP0002152_abnormal_brain_morphology0.95312443
92MP0000013_abnormal_adipose_tissue0.92617384
93MP0006072_abnormal_retinal_apoptosis0.91839999
94MP0003787_abnormal_imprinting0.90920248
95MP0003690_abnormal_glial_cell0.89842126
96MP0000747_muscle_weakness0.89837638
97MP0002069_abnormal_eating/drinking_beha0.88781879
98MP0006138_congestive_heart_failure0.87778998
99MP0002127_abnormal_cardiovascular_syste0.87553767
100MP0010630_abnormal_cardiac_muscle0.87252922
101MP0005499_abnormal_olfactory_system0.85747890
102MP0005394_taste/olfaction_phenotype0.85747890
103MP0005535_abnormal_body_temperature0.84582919
104MP0004147_increased_porphyrin_level0.83049339
105MP0001664_abnormal_digestion0.81878985
106MP0001963_abnormal_hearing_physiology0.81844746
107MP0004085_abnormal_heartbeat0.81343341
108MP0002971_abnormal_brown_adipose0.80570407
109MP0008260_abnormal_autophagy0.80329824
110MP0005409_darkened_coat_color0.80116766
111MP0000631_abnormal_neuroendocrine_gland0.78670787
112MP0005253_abnormal_eye_physiology0.76385839
113MP0001299_abnormal_eye_distance/0.75528867
114MP0001485_abnormal_pinna_reflex0.74100107
115MP0008874_decreased_physiological_sensi0.73849660
116MP0002837_dystrophic_cardiac_calcinosis0.73033688
117MP0003632_abnormal_nervous_system0.72667915
118MP0005167_abnormal_blood-brain_barrier0.69344424
119MP0002078_abnormal_glucose_homeostasis0.68324348
120MP0008877_abnormal_DNA_methylation0.65312103
121MP0004043_abnormal_pH_regulation0.64781775
122MP0005171_absent_coat_pigmentation0.64502746
123MP0000003_abnormal_adipose_tissue0.62111874
124MP0000604_amyloidosis0.61949859
125MP0002090_abnormal_vision0.60933805
126MP0003137_abnormal_impulse_conducting0.59796529
127MP0001943_abnormal_respiration0.59621407
128MP0001177_atelectasis0.57950412
129MP0005083_abnormal_biliary_tract0.57462543
130MP0004036_abnormal_muscle_relaxation0.56043648
131MP0005410_abnormal_fertilization0.55135108
132MP0005379_endocrine/exocrine_gland_phen0.53228635
133MP0003283_abnormal_digestive_organ0.50297928
134MP0002876_abnormal_thyroid_physiology0.49444371
135MP0000749_muscle_degeneration0.49030145
136MP0003956_abnormal_body_size0.48721652

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.24520444
2Nemaline bodies (HP:0003798)9.19801173
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.90423960
4Type 1 muscle fiber predominance (HP:0003803)6.95778832
5Exercise-induced myalgia (HP:0003738)6.94958096
6Exercise-induced muscle cramps (HP:0003710)6.51602212
7Myokymia (HP:0002411)6.44454855
8Muscle hypertrophy of the lower extremities (HP:0008968)5.72559324
9Focal motor seizures (HP:0011153)5.56896170
10Calf muscle hypertrophy (HP:0008981)5.19041664
11Distal arthrogryposis (HP:0005684)4.89038549
12Myopathic facies (HP:0002058)4.79947613
13EMG: myopathic abnormalities (HP:0003458)4.77930784
14Focal seizures (HP:0007359)4.52915597
15Hyporeflexia of lower limbs (HP:0002600)4.26749265
16Visual hallucinations (HP:0002367)4.26078505
17Abnormality of the calf musculature (HP:0001430)4.21547659
18Ankle clonus (HP:0011448)4.21367851
19Muscle fiber splitting (HP:0003555)4.17484251
20Limb dystonia (HP:0002451)4.15637632
21Myoglobinuria (HP:0002913)4.14647882
22Round ear (HP:0100830)4.07493388
23Rimmed vacuoles (HP:0003805)4.07451675
24Rhabdomyolysis (HP:0003201)3.95804388
25Atonic seizures (HP:0010819)3.85708192
26Supranuclear gaze palsy (HP:0000605)3.79641099
27Subaortic stenosis (HP:0001682)3.77184116
28Abnormality of the left ventricular outflow tract (HP:0011103)3.77184116
29Centrally nucleated skeletal muscle fibers (HP:0003687)3.76767655
30Pheochromocytoma (HP:0002666)3.71965775
31Sudden death (HP:0001699)3.71646819
32Neck muscle weakness (HP:0000467)3.58558182
33Frequent falls (HP:0002359)3.57010406
34Epileptic encephalopathy (HP:0200134)3.56021921
35Progressive cerebellar ataxia (HP:0002073)3.50527027
36Bundle branch block (HP:0011710)3.47031641
37Action tremor (HP:0002345)3.45655696
38Difficulty running (HP:0009046)3.45109807
39Abnormality of skeletal muscle fiber size (HP:0012084)3.37225771
40Ulnar deviation of the wrist (HP:0003049)3.35180776
41Absence seizures (HP:0002121)3.30144846
42Neuroendocrine neoplasm (HP:0100634)3.26823379
43Febrile seizures (HP:0002373)3.20125437
44Abnormality of the corticospinal tract (HP:0002492)3.16598245
45Insidious onset (HP:0003587)3.16586911
46Termporal pattern (HP:0011008)3.16586911
47Calcaneovalgus deformity (HP:0001848)3.15977740
48Fetal akinesia sequence (HP:0001989)3.14795033
49Dialeptic seizures (HP:0011146)3.14219077
50Generalized tonic-clonic seizures (HP:0002069)3.13123425
51Spastic gait (HP:0002064)3.10176298
52Muscle stiffness (HP:0003552)3.09448034
53EMG: neuropathic changes (HP:0003445)3.06299365
54Asymmetric septal hypertrophy (HP:0001670)2.95467185
55Neurofibrillary tangles (HP:0002185)2.92232593
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.91477854
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.91477854
58Urinary urgency (HP:0000012)2.90027674
59Peripheral hypomyelination (HP:0007182)2.87884542
60Absent phalangeal crease (HP:0006109)2.87002532
61Dysmetria (HP:0001310)2.81809858
62Anxiety (HP:0000739)2.81069516
63Deformed tarsal bones (HP:0008119)2.77631800
64Increased variability in muscle fiber diameter (HP:0003557)2.75770990
65Depression (HP:0000716)2.72113103
66Urinary bladder sphincter dysfunction (HP:0002839)2.71799010
67Truncal ataxia (HP:0002078)2.67431707
68Mutism (HP:0002300)2.65647598
69Abnormal eating behavior (HP:0100738)2.65311878
70Failure to thrive in infancy (HP:0001531)2.65196128
71Cerebral hypomyelination (HP:0006808)2.64855282
72Torticollis (HP:0000473)2.63336362
73Increased connective tissue (HP:0009025)2.61952824
74Distal lower limb muscle weakness (HP:0009053)2.61685142
75Broad-based gait (HP:0002136)2.61588554
76Hypothermia (HP:0002045)2.54621287
77Progressive inability to walk (HP:0002505)2.52490820
78Amblyopia (HP:0000646)2.51044201
79Areflexia of lower limbs (HP:0002522)2.47383224
80Retinal dysplasia (HP:0007973)2.47325331
81Lower limb muscle weakness (HP:0007340)2.45427444
82Scanning speech (HP:0002168)2.45036283
83Impaired vibration sensation in the lower limbs (HP:0002166)2.44987169
84Malignant hyperthermia (HP:0002047)2.43169976
85Postural instability (HP:0002172)2.41246986
86Polyphagia (HP:0002591)2.40459305
87Cerebral inclusion bodies (HP:0100314)2.39820079
88Generalized muscle weakness (HP:0003324)2.38573264
89Onion bulb formation (HP:0003383)2.35108889
90Abnormal finger flexion creases (HP:0006143)2.32743182
91Focal dystonia (HP:0004373)2.32223940
92Dilated cardiomyopathy (HP:0001644)2.29344047
93Gait imbalance (HP:0002141)2.27591983
94Craniofacial dystonia (HP:0012179)2.27470386
95Heart block (HP:0012722)2.27386894
96Clonus (HP:0002169)2.26849635
97Dysdiadochokinesis (HP:0002075)2.26638900
98Specific learning disability (HP:0001328)2.26322719
99Sensory axonal neuropathy (HP:0003390)2.24956317
100Poor eye contact (HP:0000817)2.24938749
101Ulnar claw (HP:0001178)2.24428249
102Gaze-evoked nystagmus (HP:0000640)2.22652676
103Scapular winging (HP:0003691)2.20534132
104Impaired pain sensation (HP:0007328)2.18116479
105Abnormality of pain sensation (HP:0010832)2.18116479
106Agitation (HP:0000713)2.17693726
107Abnormality of the foot musculature (HP:0001436)2.17566128
108Mildly elevated creatine phosphokinase (HP:0008180)2.15455900
109Myotonia (HP:0002486)2.15227920
110Ventricular tachycardia (HP:0004756)2.13911544
111Epileptiform EEG discharges (HP:0011182)2.13633414
112Abnormal hair whorl (HP:0010721)2.13552086
113EEG with generalized epileptiform discharges (HP:0011198)2.13317267
114Intention tremor (HP:0002080)2.12230281
115Weak cry (HP:0001612)2.10910402
116Limb-girdle muscle atrophy (HP:0003797)2.10091872
117Distal lower limb amyotrophy (HP:0008944)2.07336791
118Hypoventilation (HP:0002791)2.07027152
119Psychosis (HP:0000709)2.06702049
120Hyperventilation (HP:0002883)2.04263202
121Abnormal atrioventricular conduction (HP:0005150)2.03259849
122Hypsarrhythmia (HP:0002521)2.02322856
123Delusions (HP:0000746)2.02288270
124Lower limb amyotrophy (HP:0007210)2.01512818
125Impaired social interactions (HP:0000735)2.00838155
126Abnormal social behavior (HP:0012433)2.00838155
127Esotropia (HP:0000565)2.00507442
128Hypoplasia of the brainstem (HP:0002365)2.00426648
129Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00426648
130Gowers sign (HP:0003391)2.00078616
131Excessive salivation (HP:0003781)1.98440116
132Drooling (HP:0002307)1.98440116
133Bradykinesia (HP:0002067)1.97900752
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97432929
135Morphological abnormality of the pyramidal tract (HP:0002062)1.97326505
136Rigidity (HP:0002063)1.96997511
137Poor speech (HP:0002465)1.96931517
138Bulbar palsy (HP:0001283)1.96730069
139Neoplasm of the peripheral nervous system (HP:0100007)1.95393334
140Hyperkalemia (HP:0002153)1.94783830
141Ventricular arrhythmia (HP:0004308)1.94036058
142Poor suck (HP:0002033)1.92249811
143Postural tremor (HP:0002174)1.91501999
144Lipoatrophy (HP:0100578)1.91353979
145Genital tract atresia (HP:0001827)1.91149137
146Megalencephaly (HP:0001355)1.90137299
147Ventricular fibrillation (HP:0001663)1.89642806
148Vaginal atresia (HP:0000148)1.89256569
149Akinesia (HP:0002304)1.87906070
150Congenital primary aphakia (HP:0007707)1.87393932
151Foot dorsiflexor weakness (HP:0009027)1.85988111
152Difficulty climbing stairs (HP:0003551)1.85737109
153Muscular hypotonia of the trunk (HP:0008936)1.85461382
154Hip contracture (HP:0003273)1.85314444
155Proximal amyotrophy (HP:0007126)1.85065934
156Menstrual irregularities (HP:0000858)1.84742240
157Fatigable weakness (HP:0003473)1.84558716
158Abnormality of the neuromuscular junction (HP:0003398)1.84558716
159CNS hypomyelination (HP:0003429)1.83771388
160Hyperthyroidism (HP:0000836)1.83532948
161Hammertoe (HP:0001765)1.83381642
162Slender build (HP:0001533)1.83044155
163Waddling gait (HP:0002515)1.82790438
164Hemiparesis (HP:0001269)1.82568935
165Muscular dystrophy (HP:0003560)1.81871734
166Left ventricular hypertrophy (HP:0001712)1.81796123
167Atrial fibrillation (HP:0005110)1.81195623
168Syncope (HP:0001279)1.80801789
169Bowel incontinence (HP:0002607)1.80446227
170Abnormal EKG (HP:0003115)1.80304342
171Oligomenorrhea (HP:0000876)1.79757149
172Abnormality of the shoulder girdle musculature (HP:0001435)1.78547884
173Prolonged QT interval (HP:0001657)1.78414472
174Primary atrial arrhythmia (HP:0001692)1.78185965
175Nonprogressive disorder (HP:0003680)1.72749433
176Supraventricular tachycardia (HP:0004755)1.70811116
177Abnormality of the hip-girdle musculature (HP:0001445)1.64726763
178Abnormality of the musculature of the pelvis (HP:0001469)1.64726763
179Supraventricular arrhythmia (HP:0005115)1.64271102
180Insulin-resistant diabetes mellitus (HP:0000831)1.64067689
181Exercise intolerance (HP:0003546)1.62817981
182Respiratory insufficiency due to muscle weakness (HP:0002747)1.61744042
183Hyperinsulinemic hypoglycemia (HP:0000825)1.61279981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.65036906
2TTN4.09543371
3NTRK33.44640651
4MAP3K93.14940439
5MARK13.00130358
6CASK2.59690113
7NTRK12.55396851
8MINK12.53000878
9MAP3K42.42235489
10EPHA42.38003500
11PAK62.16218317
12KSR22.12266866
13MAP2K72.08678912
14MAP3K122.06564146
15GRK51.93724361
16MAPK121.89973886
17UHMK11.89692283
18NTRK21.88957565
19DAPK21.80526989
20MAPK131.75015774
21STK391.68508991
22PIK3CG1.65613082
23LIMK11.65454737
24OXSR11.63527539
25PHKG21.61892225
26PHKG11.61892225
27PNCK1.61202995
28PRKD31.59368091
29MAP2K41.55965349
30SGK4941.55537571
31SGK2231.55537571
32PRPF4B1.55312149
33ARAF1.55118369
34CDK191.54815380
35CDK51.48840631
36MAP3K21.38354862
37PINK11.27099948
38MAPKAPK51.26303232
39TNIK1.19980308
40CSNK1G21.18774494
41RIPK41.16821794
42CDK141.12505149
43BCR1.11163416
44DMPK1.08989942
45CSNK1G31.08063558
46CAMK2B1.07902222
47CAMK2A1.07255264
48MAP3K71.07208784
49KSR11.06542361
50CAMKK11.05249917
51CAMKK21.03031685
52CDK181.01761523
53PKN11.01285755
54PLK20.99314334
55PRKCG0.99183132
56CDK150.97927568
57DYRK1B0.97108606
58RET0.93758608
59NME10.93068728
60PAK30.89080746
61DYRK20.88841669
62MAP2K60.85811245
63CAMK40.85589144
64CDK11A0.85043714
65WNK40.84612014
66FES0.83719708
67CAMK2D0.83508331
68PRKAA10.82682198
69TYRO30.81783264
70CAMK2G0.80360614
71WNK10.78973182
72SGK30.78256002
73PRKCE0.77332028
74ADRBK20.73964622
75DAPK10.71628354
76LMTK20.70363704
77MUSK0.69764562
78DYRK1A0.69457938
79SIK30.69146770
80SIK20.68726560
81PRKCH0.67695806
82CSNK1A1L0.66825916
83WNK30.66768110
84MAP3K10.65123327
85GRK70.64921748
86MARK20.64247918
87ROCK20.64013216
88NEK60.62620791
89CSNK1G10.61010318
90STK110.60778342
91PRKG10.60152852
92MAP2K10.58612332
93MAPKAPK30.57900333
94MAP3K130.57805803
95ERBB30.57465101
96TNK20.56676416
97CAMK10.56161405
98STK380.56095250
99PRKCZ0.56043785
100CCNB10.55104066
101ADRBK10.54670587
102FRK0.54496684
103LATS20.54001081
104SGK20.53926852
105PRKAA20.53462727
106BCKDK0.51743857
107ROCK10.51739909
108DAPK30.51533638
109RPS6KA20.50306971
110PDPK10.49096000
111FER0.48342450
112FGFR20.47991050
113BRAF0.46799910
114SGK10.46532251
115MOS0.46339711
116MAPK40.44766617
117TRPM70.44211099
118PRKACA0.42870573
119MAP2K30.42223793
120FGR0.41565730
121AKT20.41435213
122FYN0.40253806
123MAPK100.40159963
124MAP3K110.39988570
125RPS6KA30.39971596
126MAPK70.38899040
127RIPK10.38886406
128PIK3CA0.38333994
129RAF10.35777825
130PRKACB0.34180378
131RPS6KB10.28559884
132PRKACG0.25740762
133PDK10.25569387

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.71682932
2Nicotine addiction_Homo sapiens_hsa050333.22986125
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.80564718
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72722537
5GABAergic synapse_Homo sapiens_hsa047272.66743347
6Olfactory transduction_Homo sapiens_hsa047402.46383182
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41178622
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36970222
9Morphine addiction_Homo sapiens_hsa050322.30145030
10Circadian entrainment_Homo sapiens_hsa047132.25054913
11Glutamatergic synapse_Homo sapiens_hsa047242.23141479
12Dopaminergic synapse_Homo sapiens_hsa047282.14710550
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.13484295
14Amphetamine addiction_Homo sapiens_hsa050312.11387883
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07191542
16Collecting duct acid secretion_Homo sapiens_hsa049662.06977140
17Insulin secretion_Homo sapiens_hsa049112.04580961
18Cocaine addiction_Homo sapiens_hsa050301.98215455
19Serotonergic synapse_Homo sapiens_hsa047261.91750882
20Long-term potentiation_Homo sapiens_hsa047201.91586034
21Taste transduction_Homo sapiens_hsa047421.84568287
22Cholinergic synapse_Homo sapiens_hsa047251.81167898
23Salivary secretion_Homo sapiens_hsa049701.79206915
24Oxidative phosphorylation_Homo sapiens_hsa001901.67958961
25Cardiac muscle contraction_Homo sapiens_hsa042601.60919990
26Long-term depression_Homo sapiens_hsa047301.58639485
27Vibrio cholerae infection_Homo sapiens_hsa051101.58361264
28Glucagon signaling pathway_Homo sapiens_hsa049221.57263690
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55257399
30Gastric acid secretion_Homo sapiens_hsa049711.53963705
31Parkinsons disease_Homo sapiens_hsa050121.51841584
32Phototransduction_Homo sapiens_hsa047441.49769659
33Renin secretion_Homo sapiens_hsa049241.47171495
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44022065
35Arginine and proline metabolism_Homo sapiens_hsa003301.43996844
36Gap junction_Homo sapiens_hsa045401.39627634
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38321190
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33010097
39Oxytocin signaling pathway_Homo sapiens_hsa049211.32993443
40Pancreatic secretion_Homo sapiens_hsa049721.31410607
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29134327
42Calcium signaling pathway_Homo sapiens_hsa040201.28989995
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24201850
44Alzheimers disease_Homo sapiens_hsa050101.23962645
45Arginine biosynthesis_Homo sapiens_hsa002201.20181106
46GnRH signaling pathway_Homo sapiens_hsa049121.18856811
47Axon guidance_Homo sapiens_hsa043601.16023690
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14827284
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04924433
50Propanoate metabolism_Homo sapiens_hsa006401.02554684
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99990547
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97987483
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97530895
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96389989
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95230464
56cAMP signaling pathway_Homo sapiens_hsa040240.93647011
57Carbon metabolism_Homo sapiens_hsa012000.92631157
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.91585619
59Estrogen signaling pathway_Homo sapiens_hsa049150.90454789
60AMPK signaling pathway_Homo sapiens_hsa041520.88879295
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88134722
62Type II diabetes mellitus_Homo sapiens_hsa049300.85696896
63ErbB signaling pathway_Homo sapiens_hsa040120.84408438
64Huntingtons disease_Homo sapiens_hsa050160.81944030
65Melanogenesis_Homo sapiens_hsa049160.79399181
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79126131
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.78802946
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76565984
69Fatty acid metabolism_Homo sapiens_hsa012120.71678886
70Dorso-ventral axis formation_Homo sapiens_hsa043200.71167128
71Pyruvate metabolism_Homo sapiens_hsa006200.70760339
72Insulin resistance_Homo sapiens_hsa049310.69570654
73Fatty acid degradation_Homo sapiens_hsa000710.66740452
74Glioma_Homo sapiens_hsa052140.66621973
75Alcoholism_Homo sapiens_hsa050340.66313299
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.66113565
77Ether lipid metabolism_Homo sapiens_hsa005650.64035075
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63432101
79Thyroid hormone synthesis_Homo sapiens_hsa049180.63292530
80Nitrogen metabolism_Homo sapiens_hsa009100.62745369
81Oocyte meiosis_Homo sapiens_hsa041140.61051438
82beta-Alanine metabolism_Homo sapiens_hsa004100.59698618
83Choline metabolism in cancer_Homo sapiens_hsa052310.59325937
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59102428
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58464956
86Phenylalanine metabolism_Homo sapiens_hsa003600.57568682
87MAPK signaling pathway_Homo sapiens_hsa040100.56766549
88Dilated cardiomyopathy_Homo sapiens_hsa054140.56598023
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56281612
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.56095155
91Prion diseases_Homo sapiens_hsa050200.56070574
92Tight junction_Homo sapiens_hsa045300.55022168
93Endocytosis_Homo sapiens_hsa041440.54827947
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.54296397
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54022813
96Regulation of autophagy_Homo sapiens_hsa041400.53593760
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.51635316
98Ras signaling pathway_Homo sapiens_hsa040140.50848567
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48200802
100Renal cell carcinoma_Homo sapiens_hsa052110.46920668
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46462092
102Phagosome_Homo sapiens_hsa041450.45556940
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.45286594
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44825153
105Circadian rhythm_Homo sapiens_hsa047100.42533361
106Rheumatoid arthritis_Homo sapiens_hsa053230.41274672
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40790224
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40395617
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39457151
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39362415
111Fatty acid elongation_Homo sapiens_hsa000620.39061236
112Fructose and mannose metabolism_Homo sapiens_hsa000510.38411583
113Inositol phosphate metabolism_Homo sapiens_hsa005620.37673637
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37585755
115VEGF signaling pathway_Homo sapiens_hsa043700.36224821
116Insulin signaling pathway_Homo sapiens_hsa049100.36089959
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35283955
118Starch and sucrose metabolism_Homo sapiens_hsa005000.34748830
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34408817
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34393097
121Tryptophan metabolism_Homo sapiens_hsa003800.32761191
122Type I diabetes mellitus_Homo sapiens_hsa049400.32328775
123Steroid biosynthesis_Homo sapiens_hsa001000.32089657
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31806559
125Rap1 signaling pathway_Homo sapiens_hsa040150.31184802
126Bile secretion_Homo sapiens_hsa049760.30661804
127Butanoate metabolism_Homo sapiens_hsa006500.29553475
128Ovarian steroidogenesis_Homo sapiens_hsa049130.28781446
129Vitamin B6 metabolism_Homo sapiens_hsa007500.27832631
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27667942
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27420072

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