DUSP28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.60435059
2DNA deamination (GO:0045006)4.74672905
3coenzyme catabolic process (GO:0009109)4.67344313
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32089297
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.10526144
6respiratory electron transport chain (GO:0022904)4.01153606
7protein maturation by protein folding (GO:0022417)3.98327384
8electron transport chain (GO:0022900)3.95617680
9ATP synthesis coupled proton transport (GO:0015986)3.86759520
10energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86759520
11negative regulation of telomere maintenance (GO:0032205)3.73020125
12piRNA metabolic process (GO:0034587)3.71920827
13detection of light stimulus involved in sensory perception (GO:0050962)3.62787269
14detection of light stimulus involved in visual perception (GO:0050908)3.62787269
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.60352239
16L-phenylalanine catabolic process (GO:0006559)3.60352239
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.60251092
18L-phenylalanine metabolic process (GO:0006558)3.60251092
19succinate metabolic process (GO:0006105)3.55197947
20neuronal action potential propagation (GO:0019227)3.53238810
21neuromuscular process controlling posture (GO:0050884)3.47616524
22regulation of oxidative phosphorylation (GO:0002082)3.42190412
23cofactor catabolic process (GO:0051187)3.40364176
24L-fucose metabolic process (GO:0042354)3.39261759
25L-fucose catabolic process (GO:0042355)3.39261759
26fucose catabolic process (GO:0019317)3.39261759
27COPI coating of Golgi vesicle (GO:0048205)3.35915989
28Golgi transport vesicle coating (GO:0048200)3.35915989
29indolalkylamine metabolic process (GO:0006586)3.29713666
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26492258
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23289280
32tricarboxylic acid metabolic process (GO:0072350)3.20042009
33tryptophan catabolic process (GO:0006569)3.19819147
34indole-containing compound catabolic process (GO:0042436)3.19819147
35indolalkylamine catabolic process (GO:0046218)3.19819147
36synaptic vesicle exocytosis (GO:0016079)3.19534966
37response to pheromone (GO:0019236)3.18264681
38protein polyglutamylation (GO:0018095)3.16569025
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13954666
40NADH metabolic process (GO:0006734)3.11556768
41tryptophan metabolic process (GO:0006568)3.05954246
42short-chain fatty acid metabolic process (GO:0046459)3.02553348
43protein complex biogenesis (GO:0070271)3.01931893
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.01473196
45NADH dehydrogenase complex assembly (GO:0010257)3.01473196
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01473196
47acetyl-CoA metabolic process (GO:0006084)2.97497192
48positive regulation of defense response to virus by host (GO:0002230)2.97263711
49neuronal action potential (GO:0019228)2.96702553
50axoneme assembly (GO:0035082)2.96345783
51tricarboxylic acid cycle (GO:0006099)2.96050551
52coenzyme A metabolic process (GO:0015936)2.95530698
53kynurenine metabolic process (GO:0070189)2.93417130
54mitochondrial respiratory chain complex assembly (GO:0033108)2.93232543
55synaptic vesicle maturation (GO:0016188)2.91937322
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89982777
57signal peptide processing (GO:0006465)2.89494136
58mitochondrial calcium ion transport (GO:0006851)2.89095700
59preassembly of GPI anchor in ER membrane (GO:0016254)2.88372122
60negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.88244558
61cytidine metabolic process (GO:0046087)2.87519818
62cytidine catabolic process (GO:0006216)2.87519818
63cytidine deamination (GO:0009972)2.87519818
64regulation of action potential (GO:0098900)2.86815914
65establishment of viral latency (GO:0019043)2.86292119
66ketone body metabolic process (GO:1902224)2.82930921
67DNA methylation involved in gamete generation (GO:0043046)2.81430315
68oxaloacetate metabolic process (GO:0006107)2.79096752
69synaptic transmission, cholinergic (GO:0007271)2.76601633
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74993932
71heme transport (GO:0015886)2.74525862
72ubiquinone biosynthetic process (GO:0006744)2.74320053
73calcium-mediated signaling using intracellular calcium source (GO:0035584)2.73842359
742-oxoglutarate metabolic process (GO:0006103)2.73410222
75response to ischemia (GO:0002931)2.72526426
76negative regulation of mast cell activation (GO:0033004)2.71773388
77negative regulation of interleukin-1 beta production (GO:0032691)2.71326313
78protein neddylation (GO:0045116)2.70805055
79cilium or flagellum-dependent cell motility (GO:0001539)2.70553463
80adaptation of signaling pathway (GO:0023058)2.70339703
81epithelial cilium movement (GO:0003351)2.70148007
82valine metabolic process (GO:0006573)2.68681210
83detection of calcium ion (GO:0005513)2.68077451
84peptide hormone processing (GO:0016486)2.66738725
85regulation of cilium movement (GO:0003352)2.65843593
86acyl-CoA biosynthetic process (GO:0071616)2.64334664
87thioester biosynthetic process (GO:0035384)2.64334664
88energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.64318964
89ATP hydrolysis coupled proton transport (GO:0015991)2.64318964
90indole-containing compound metabolic process (GO:0042430)2.63813788
91negative regulation of glycoprotein biosynthetic process (GO:0010561)2.61954536
92cellular response to exogenous dsRNA (GO:0071360)2.59778264
93regulation of memory T cell differentiation (GO:0043380)2.59588912
94dicarboxylic acid catabolic process (GO:0043649)2.55416763
95rRNA catabolic process (GO:0016075)2.55179940
96primary amino compound metabolic process (GO:1901160)2.55011692
97negative regulation of reactive oxygen species metabolic process (GO:2000378)2.53995847
98retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53906322
99positive regulation of insulin secretion (GO:0032024)2.51991045
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.51649448
101induction of positive chemotaxis (GO:0050930)2.50978752
102regulation of microtubule-based movement (GO:0060632)2.50608988
103iron coordination entity transport (GO:1901678)2.49518563
104positive regulation of prostaglandin secretion (GO:0032308)2.48891421
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.48878762
106neural tube formation (GO:0001841)2.48703490
107purinergic nucleotide receptor signaling pathway (GO:0035590)2.48620259
108fatty acid beta-oxidation (GO:0006635)2.47898295
109hydrogen ion transmembrane transport (GO:1902600)2.47879733
110negative regulation of appetite (GO:0032099)2.47814217
111negative regulation of response to food (GO:0032096)2.47814217
112L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46794595
113pseudouridine synthesis (GO:0001522)2.46476235
114mitotic cell cycle arrest (GO:0071850)2.46138857
115regulation of type B pancreatic cell apoptotic process (GO:2000674)2.45987146
116serotonin metabolic process (GO:0042428)2.45757975
117ribonucleoside bisphosphate metabolic process (GO:0033875)2.45129809
118nucleoside bisphosphate metabolic process (GO:0033865)2.45129809
119purine nucleoside bisphosphate metabolic process (GO:0034032)2.45129809
120ubiquinone metabolic process (GO:0006743)2.45047158
121oxidative phosphorylation (GO:0006119)2.44431921
122sulfation (GO:0051923)2.43998620
123regulation of telomere maintenance (GO:0032204)2.43936846
124fatty acid catabolic process (GO:0009062)2.43555508
125sarcoplasmic reticulum calcium ion transport (GO:0070296)2.43048443
126negative regulation of interleukin-1 production (GO:0032692)2.42838818
127anterograde synaptic vesicle transport (GO:0048490)2.42670673
128ATP biosynthetic process (GO:0006754)2.42503978
129behavioral response to ethanol (GO:0048149)2.42390733
130insulin secretion (GO:0030073)2.41803016
131antigen processing and presentation via MHC class Ib (GO:0002475)2.41553526
132activated T cell proliferation (GO:0050798)2.40419439
133cellular response to ATP (GO:0071318)2.39981103
134glutamate secretion (GO:0014047)2.38989875
135dopamine transport (GO:0015872)2.38896900
136membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38496306
137interkinetic nuclear migration (GO:0022027)2.38314695
138cornea development in camera-type eye (GO:0061303)2.38023143
139positive regulation of oligodendrocyte differentiation (GO:0048714)2.37572829
140respiratory chain complex IV assembly (GO:0008535)2.37399433
141glutamate metabolic process (GO:0006536)2.37121119
142activation of protein kinase A activity (GO:0034199)2.36017083
143alkaloid metabolic process (GO:0009820)2.34005021
144alpha-linolenic acid metabolic process (GO:0036109)2.33503086
145cellular ketone body metabolic process (GO:0046950)2.33192279
146negative regulation of heart rate (GO:0010459)2.32852833
147response to misfolded protein (GO:0051788)2.32825603
148somite development (GO:0061053)2.32590109
149cellular response to glucagon stimulus (GO:0071377)2.32147169
150aspartate family amino acid catabolic process (GO:0009068)2.31950595
151regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.31922162
152generation of precursor metabolites and energy (GO:0006091)2.31681644
153pyrimidine ribonucleoside catabolic process (GO:0046133)2.31528706
154multicellular organism reproduction (GO:0032504)2.31440410
155cellular modified amino acid catabolic process (GO:0042219)2.30921042
156glycerophospholipid catabolic process (GO:0046475)2.30782215
157positive regulation of fatty acid transport (GO:2000193)2.30021045
158cell proliferation in forebrain (GO:0021846)2.29958508
159reciprocal meiotic recombination (GO:0007131)2.29803512
160reciprocal DNA recombination (GO:0035825)2.29803512
161NAD biosynthetic process (GO:0009435)2.29791833
162membrane depolarization during action potential (GO:0086010)2.29462188
163kidney morphogenesis (GO:0060993)2.29292107
164positive regulation of triglyceride biosynthetic process (GO:0010867)2.29186459
165regulation of rhodopsin mediated signaling pathway (GO:0022400)2.29003911
166regulation of acyl-CoA biosynthetic process (GO:0050812)2.28928428
167regulation of amyloid precursor protein catabolic process (GO:1902991)2.28888488
168protein localization to cilium (GO:0061512)2.28508489
169protein retention in ER lumen (GO:0006621)2.28497927
170gluconeogenesis (GO:0006094)2.28261047
171monocarboxylic acid catabolic process (GO:0072329)2.27737760
172maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.27512472
173gamma-aminobutyric acid transport (GO:0015812)2.27438764
174protein-cofactor linkage (GO:0018065)2.27258278
175mannosylation (GO:0097502)2.27254396
176water-soluble vitamin biosynthetic process (GO:0042364)2.27047973
177antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27026073
178antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27026073
179neurotransmitter secretion (GO:0007269)2.26811691
180fatty acid oxidation (GO:0019395)2.26694463
181rhodopsin mediated signaling pathway (GO:0016056)2.26435776
182aromatic amino acid family catabolic process (GO:0009074)2.26392305
183DNA demethylation (GO:0080111)2.26245290
184pteridine-containing compound biosynthetic process (GO:0042559)2.26019508
185branched-chain amino acid catabolic process (GO:0009083)2.25988578
186lipid oxidation (GO:0034440)2.25614669
187amine catabolic process (GO:0009310)2.25137032
188cellular biogenic amine catabolic process (GO:0042402)2.25137032
189male meiosis I (GO:0007141)2.24818425
190cytochrome complex assembly (GO:0017004)2.24057721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.96383266
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60075813
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.31787351
4VDR_22108803_ChIP-Seq_LS180_Human3.25831177
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.90534922
6EZH2_22144423_ChIP-Seq_EOC_Human2.73700844
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.61668305
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.60547538
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57186646
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46291082
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.43753000
12GBX2_23144817_ChIP-Seq_PC3_Human2.43329773
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31965670
14IGF1R_20145208_ChIP-Seq_DFB_Human2.29813126
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23396299
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22629630
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.12870098
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.11382619
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10166971
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06591149
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.99206684
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98187468
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96875271
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.96053635
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95624117
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95450940
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94637542
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93625827
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.91418783
30ER_23166858_ChIP-Seq_MCF-7_Human1.91026503
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86865253
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82220456
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.75449240
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74402259
35FUS_26573619_Chip-Seq_HEK293_Human1.73469490
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.71997200
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.71487594
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68800404
39TP53_22573176_ChIP-Seq_HFKS_Human1.68527394
40ZNF263_19887448_ChIP-Seq_K562_Human1.68372824
41EWS_26573619_Chip-Seq_HEK293_Human1.68005223
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66053209
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63723779
44LXR_22292898_ChIP-Seq_THP-1_Human1.63530574
45* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62697399
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62658399
47REST_21632747_ChIP-Seq_MESCs_Mouse1.62552316
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59858404
49P300_19829295_ChIP-Seq_ESCs_Human1.59570265
50TAF15_26573619_Chip-Seq_HEK293_Human1.58942047
51SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.58908569
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58255084
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56210011
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54471681
55IRF1_19129219_ChIP-ChIP_H3396_Human1.53020567
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.48886003
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47412908
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45065223
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44656444
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.44219357
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.41936435
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41936435
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41791676
64BCAT_22108803_ChIP-Seq_LS180_Human1.41617359
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.41204020
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40294615
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39445580
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39096166
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37293326
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37251090
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34853307
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33366666
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32157757
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31355524
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31233675
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31078952
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31062889
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30767044
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.30714752
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30207384
81MYC_18940864_ChIP-ChIP_HL60_Human1.28858345
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28409115
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28409115
84* RARB_27405468_Chip-Seq_BRAIN_Mouse1.28174257
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27319659
86AR_25329375_ChIP-Seq_VCAP_Human1.25615719
87* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25512121
88NCOR_22424771_ChIP-Seq_293T_Human1.25144020
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24202741
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.23227276
91CBP_20019798_ChIP-Seq_JUKART_Human1.23184774
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23184774
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23062770
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22361223
95NANOG_19829295_ChIP-Seq_ESCs_Human1.21659090
96SOX2_19829295_ChIP-Seq_ESCs_Human1.21659090
97ERA_21632823_ChIP-Seq_H3396_Human1.21646357
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21285446
99* BCL6_27268052_Chip-Seq_Bcells_Human1.20631543
100* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20595691
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.20558176
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19532622
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19323200
104SA1_27219007_Chip-Seq_Bcells_Human1.18582770
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.18482805
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.17963324
107STAT3_23295773_ChIP-Seq_U87_Human1.17821068
108TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17702278
109TCF4_23295773_ChIP-Seq_U87_Human1.16768188
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16241141
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15987438
112NANOG_20526341_ChIP-Seq_ESCs_Human1.15879034
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15491680
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15348705
115ZNF274_21170338_ChIP-Seq_K562_Hela1.15221037
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.15027522
117AR_20517297_ChIP-Seq_VCAP_Human1.14931684
118ETS1_20019798_ChIP-Seq_JURKAT_Human1.14711999
119SMAD4_21799915_ChIP-Seq_A2780_Human1.14203028
120HOXB7_26014856_ChIP-Seq_BT474_Human1.13958161
121GATA3_26560356_Chip-Seq_TH2_Human1.13845510
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12323492
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10996727
124RNF2_27304074_Chip-Seq_NSC_Mouse1.10322243
125MYC_19829295_ChIP-Seq_ESCs_Human1.09914013
126SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09650994
127CTCF_26484167_Chip-Seq_Bcells_Mouse1.08986557
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08435531
129GATA1_22025678_ChIP-Seq_K562_Human1.08327595
130SRF_21415370_ChIP-Seq_HL-1_Mouse1.08312137
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08260372
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08182872
133TAF2_19829295_ChIP-Seq_ESCs_Human1.08173272
134* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08044773
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.07693772
136BCOR_27268052_Chip-Seq_Bcells_Human1.07637471
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07535349
138VDR_23849224_ChIP-Seq_CD4+_Human1.07378222
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07078019
140SOX2_21211035_ChIP-Seq_LN229_Human1.06420005
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06396040
142OCT4_20526341_ChIP-Seq_ESCs_Human1.04688020
143CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04297624
144KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03742649
145CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03590858
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03541929
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03541171
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02932563
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02175600
150GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02131595
151YY1_21170310_ChIP-Seq_MESCs_Mouse1.01942451
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99951063
153PHF8_20622854_ChIP-Seq_HELA_Human0.99206898
154AR_21572438_ChIP-Seq_LNCaP_Human0.98707217
155PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98102733
156* P53_21459846_ChIP-Seq_SAOS-2_Human0.97448534
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97385386
158P68_20966046_ChIP-Seq_HELA_Human0.97317013
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.97172770
160AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96942160
161ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96537359
162SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95761238
163TCF4_22108803_ChIP-Seq_LS180_Human0.95723305
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.95529850
165TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95015228
166TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94206387
167EZH2_27294783_Chip-Seq_ESCs_Mouse0.94088587
168ERG_20517297_ChIP-Seq_VCAP_Human0.93704248
169HTT_18923047_ChIP-ChIP_STHdh_Human0.93483480
170MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93459021
171GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92459486
172CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91428625
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91026866
174HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90815352
175GATA1_19941827_ChIP-Seq_MEL_Mouse0.90499789
176HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90296822
177SCL_19346495_ChIP-Seq_HPC-7_Human0.89319236
178RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87939165
179CTCF_27219007_Chip-Seq_Bcells_Human0.87415875
180* SA1_27219007_Chip-Seq_ERYTHROID_Human0.85121349
181EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85064694
182* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84312209
183PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83141246
184FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82986736
185PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82418968
186BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81965095
187FOXP1_21924763_ChIP-Seq_HESCs_Human0.80296482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis2.93248422
2MP0002139_abnormal_hepatobiliary_system2.90127431
3MP0006036_abnormal_mitochondrial_physio2.71250837
4MP0002909_abnormal_adrenal_gland2.63908056
5MP0008877_abnormal_DNA_methylation2.49518602
6MP0003195_calcinosis2.46457796
7MP0002102_abnormal_ear_morphology2.27095634
8MP0005551_abnormal_eye_electrophysiolog2.25337640
9MP0010386_abnormal_urinary_bladder2.19155253
10MP0002822_catalepsy2.18791762
11MP0004859_abnormal_synaptic_plasticity2.18528689
12MP0009840_abnormal_foam_cell2.17392300
13MP0005379_endocrine/exocrine_gland_phen2.16372166
14MP0003787_abnormal_imprinting2.14195203
15MP0005085_abnormal_gallbladder_physiolo2.11700236
16MP0003329_amyloid_beta_deposits2.09730338
17MP0006292_abnormal_olfactory_placode2.08762173
18MP0005083_abnormal_biliary_tract2.08047931
19MP0003183_abnormal_peptide_metabolism2.02241874
20MP0005365_abnormal_bile_salt2.01887205
21MP0005360_urolithiasis2.01098873
22MP0004043_abnormal_pH_regulation1.99521409
23MP0003806_abnormal_nucleotide_metabolis1.98477725
24MP0005058_abnormal_lysosome_morphology1.90095910
25MP0002638_abnormal_pupillary_reflex1.85986189
26MP0004145_abnormal_muscle_electrophysio1.84312053
27MP0005167_abnormal_blood-brain_barrier1.83705086
28MP0002693_abnormal_pancreas_physiology1.83633457
29MP0004858_abnormal_nervous_system1.81950454
30MP0002653_abnormal_ependyma_morphology1.79475539
31MP0003136_yellow_coat_color1.78538982
32MP0003646_muscle_fatigue1.76257810
33MP0003172_abnormal_lysosome_physiology1.70950065
34MP0005535_abnormal_body_temperature1.67244143
35MP0005645_abnormal_hypothalamus_physiol1.63472933
36MP0006035_abnormal_mitochondrial_morpho1.62996373
37MP0002078_abnormal_glucose_homeostasis1.61430021
38MP0003635_abnormal_synaptic_transmissio1.60776054
39MP0004270_analgesia1.59749195
40MP0008875_abnormal_xenobiotic_pharmacok1.59472562
41MP0005253_abnormal_eye_physiology1.57176556
42MP0001944_abnormal_pancreas_morphology1.56784148
43MP0003880_abnormal_central_pattern1.55639918
44MP0006072_abnormal_retinal_apoptosis1.55120873
45MP0005671_abnormal_response_to1.54073287
46MP0000751_myopathy1.53927475
47MP0003011_delayed_dark_adaptation1.52661334
48MP0004742_abnormal_vestibular_system1.51560186
49MP0001984_abnormal_olfaction1.51148948
50MP0005636_abnormal_mineral_homeostasis1.49579629
51MP0002733_abnormal_thermal_nociception1.49366090
52MP0000569_abnormal_digit_pigmentation1.49293974
53MP0005332_abnormal_amino_acid1.48430457
54MP0005584_abnormal_enzyme/coenzyme_acti1.46049854
55MP0002064_seizures1.45004187
56MP0000013_abnormal_adipose_tissue1.43631882
57MP0001986_abnormal_taste_sensitivity1.42870600
58MP0001485_abnormal_pinna_reflex1.42671017
59MP0002163_abnormal_gland_morphology1.42525245
60MP0002736_abnormal_nociception_after1.41678278
61MP0000604_amyloidosis1.39841193
62MP0008961_abnormal_basal_metabolism1.37729121
63MP0006276_abnormal_autonomic_nervous1.37027667
64MP0001970_abnormal_pain_threshold1.31841092
65MP0004133_heterotaxia1.31756352
66MP0003656_abnormal_erythrocyte_physiolo1.29825551
67MP0002272_abnormal_nervous_system1.27242540
68MP0000230_abnormal_systemic_arterial1.26925281
69MP0001666_abnormal_nutrient_absorption1.25958552
70MP0009046_muscle_twitch1.24641539
71MP0004885_abnormal_endolymph1.24380478
72MP0004215_abnormal_myocardial_fiber1.23517906
73MP0002118_abnormal_lipid_homeostasis1.23204328
74MP0000372_irregular_coat_pigmentation1.22403767
75MP0005423_abnormal_somatic_nervous1.22107484
76MP0009745_abnormal_behavioral_response1.22065307
77MP0002277_abnormal_respiratory_mucosa1.22048506
78MP0001905_abnormal_dopamine_level1.21706988
79MP0005084_abnormal_gallbladder_morpholo1.21098408
80MP0001919_abnormal_reproductive_system1.20781205
81MP0005389_reproductive_system_phenotype1.19338511
82MP0000747_muscle_weakness1.18076326
83MP0001501_abnormal_sleep_pattern1.17289732
84MP0009643_abnormal_urine_homeostasis1.17238019
85MP0001835_abnormal_antigen_presentation1.16591410
86MP0000749_muscle_degeneration1.15614879
87MP0004510_myositis1.15409327
88MP0008775_abnormal_heart_ventricle1.14903918
89MP0010329_abnormal_lipoprotein_level1.14334550
90MP0003879_abnormal_hair_cell1.13980011
91MP0004130_abnormal_muscle_cell1.13553454
92MP0001764_abnormal_homeostasis1.12342147
93MP0004142_abnormal_muscle_tone1.12055929
94MP0001529_abnormal_vocalization1.11259430
95MP0001486_abnormal_startle_reflex1.10986087
96MP0004036_abnormal_muscle_relaxation1.10692994
97MP0003191_abnormal_cellular_cholesterol1.10460839
98MP0001800_abnormal_humoral_immune1.10017917
99MP0001968_abnormal_touch/_nociception1.08786044
100MP0002269_muscular_atrophy1.08562638
101MP0002160_abnormal_reproductive_system1.08539242
102MP0005448_abnormal_energy_balance1.07573316
103MP0002557_abnormal_social/conspecific_i1.07265614
104MP0005410_abnormal_fertilization1.07022130
105MP0003186_abnormal_redox_activity1.06416888
106MP0009764_decreased_sensitivity_to1.06087157
107MP0008569_lethality_at_weaning1.04368995
108MP0001765_abnormal_ion_homeostasis1.04253973
109MP0002735_abnormal_chemical_nociception1.03789040
110MP0000427_abnormal_hair_cycle1.02366163
111MP0002876_abnormal_thyroid_physiology1.02047851
112MP0001502_abnormal_circadian_rhythm0.99919311
113MP0003724_increased_susceptibility_to0.98112625
114MP0002734_abnormal_mechanical_nocicepti0.97805225
115MP0003959_abnormal_lean_body0.97774756
116MP0003866_abnormal_defecation0.96414775
117MP0000631_abnormal_neuroendocrine_gland0.96381083
118MP0005319_abnormal_enzyme/_coenzyme0.95060339
119MP0005310_abnormal_salivary_gland0.94521484
120MP0004147_increased_porphyrin_level0.92130850
121MP0002572_abnormal_emotion/affect_behav0.91723970
122MP0005075_abnormal_melanosome_morpholog0.91398214
123MP0002063_abnormal_learning/memory/cond0.90458091
124MP0000609_abnormal_liver_physiology0.90430392
125MP0003868_abnormal_feces_composition0.90183998
126MP0005174_abnormal_tail_pigmentation0.89722780
127MP0002229_neurodegeneration0.89128200
128MP0002067_abnormal_sensory_capabilities0.89113519
129MP0000685_abnormal_immune_system0.88804142
130MP0003953_abnormal_hormone_level0.88565180
131MP0002148_abnormal_hypersensitivity_rea0.88264974
132MP0002095_abnormal_skin_pigmentation0.88048963
133MP0008260_abnormal_autophagy0.87169082
134MP0005646_abnormal_pituitary_gland0.86802157
135MP0008995_early_reproductive_senescence0.85149538
136MP0002723_abnormal_immune_serum0.84667146
137MP0005195_abnormal_posterior_eye0.84237762
138MP0008872_abnormal_physiological_respon0.82880756
139MP0002877_abnormal_melanocyte_morpholog0.82105637
140MP0001440_abnormal_grooming_behavior0.81213294
141MP0001873_stomach_inflammation0.81005664
142MP0004484_altered_response_of0.80876304
143MP0009642_abnormal_blood_homeostasis0.80795829
144MP0004924_abnormal_behavior0.80672370
145MP0005386_behavior/neurological_phenoty0.80672370
146MP0003137_abnormal_impulse_conducting0.80561513
147MP0009785_altered_susceptibility_to0.80356149
148MP0005220_abnormal_exocrine_pancreas0.80144699
149MP0005000_abnormal_immune_tolerance0.80024327
150MP0003718_maternal_effect0.78441098
151MP0005266_abnormal_metabolism0.77665600
152MP0001963_abnormal_hearing_physiology0.76427284
153MP0002928_abnormal_bile_duct0.73944126
154MP0002452_abnormal_antigen_presenting0.72820538

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.35470127
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.08820414
3Hypoglycemic coma (HP:0001325)3.90540719
4Visual hallucinations (HP:0002367)3.82481507
5Pancreatic cysts (HP:0001737)3.81408958
6Hepatic necrosis (HP:0002605)3.72214506
7Abnormal mitochondria in muscle tissue (HP:0008316)3.69438667
8Acute necrotizing encephalopathy (HP:0006965)3.65538069
9Acute encephalopathy (HP:0006846)3.55573899
10Hypoglycemic seizures (HP:0002173)3.54067043
11Hepatocellular necrosis (HP:0001404)3.51553760
12Molar tooth sign on MRI (HP:0002419)3.50380705
13Abnormality of midbrain morphology (HP:0002418)3.50380705
14Ketosis (HP:0001946)3.49833302
15Pancreatic fibrosis (HP:0100732)3.40515617
16Mitochondrial inheritance (HP:0001427)3.33863444
17Attenuation of retinal blood vessels (HP:0007843)3.26736774
18True hermaphroditism (HP:0010459)3.23270837
19Pheochromocytoma (HP:0002666)3.17380579
20Ketoacidosis (HP:0001993)3.17215669
21Progressive macrocephaly (HP:0004481)3.14574590
22Neuroendocrine neoplasm (HP:0100634)3.10226565
23Nephronophthisis (HP:0000090)3.09655086
24Abnormal rod and cone electroretinograms (HP:0008323)3.06269351
25Decreased central vision (HP:0007663)3.05597561
26Hyperinsulinemic hypoglycemia (HP:0000825)2.99796622
27Abolished electroretinogram (ERG) (HP:0000550)2.99444855
28Late onset (HP:0003584)2.96907584
29Hyperventilation (HP:0002883)2.87753213
30Cerebral edema (HP:0002181)2.87399041
31Pendular nystagmus (HP:0012043)2.81255242
32Lactic acidosis (HP:0003128)2.80916268
33Myokymia (HP:0002411)2.79032685
34Increased CSF lactate (HP:0002490)2.77818769
35Genetic anticipation (HP:0003743)2.77004140
36Abnormality of the renal cortex (HP:0011035)2.71522930
37Symptomatic seizures (HP:0011145)2.69527978
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68988929
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68988929
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.68490336
41Myoglobinuria (HP:0002913)2.67586332
42Birth length less than 3rd percentile (HP:0003561)2.65186314
43Lissencephaly (HP:0001339)2.64415560
44Abnormality of the renal medulla (HP:0100957)2.62696167
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62575253
46Progressive cerebellar ataxia (HP:0002073)2.61706949
47Dicarboxylic aciduria (HP:0003215)2.60246219
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60246219
49Medial flaring of the eyebrow (HP:0010747)2.56075957
50Inability to walk (HP:0002540)2.55197221
51Focal motor seizures (HP:0011153)2.50856030
52Abnormal drinking behavior (HP:0030082)2.50685085
53Polydipsia (HP:0001959)2.50685085
54Gout (HP:0001997)2.49500429
55Cerebellar dysplasia (HP:0007033)2.48475116
56Stomatitis (HP:0010280)2.46184750
57Abnormality of alanine metabolism (HP:0010916)2.45731725
58Hyperalaninemia (HP:0003348)2.45731725
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45731725
60Methylmalonic aciduria (HP:0012120)2.45137369
61Hypothermia (HP:0002045)2.45014918
62Increased muscle lipid content (HP:0009058)2.42150699
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.39573604
64Generalized aminoaciduria (HP:0002909)2.39520198
65Increased intramyocellular lipid droplets (HP:0012240)2.39030194
66Increased cerebral lipofuscin (HP:0011813)2.37372349
67Abnormal respiratory epithelium morphology (HP:0012253)2.37046081
68Abnormal respiratory motile cilium morphology (HP:0005938)2.37046081
69Exercise-induced myalgia (HP:0003738)2.35377256
70Chronic hepatic failure (HP:0100626)2.32133107
71Protruding tongue (HP:0010808)2.32040566
72Methylmalonic acidemia (HP:0002912)2.27362879
73Lethargy (HP:0001254)2.24205213
74Xanthomatosis (HP:0000991)2.20569007
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20357528
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.19899659
77Absent/shortened dynein arms (HP:0200106)2.19899659
78Bony spicule pigmentary retinopathy (HP:0007737)2.19369420
79Optic disc pallor (HP:0000543)2.18874241
80Progressive neurologic deterioration (HP:0002344)2.18267943
81Ragged-red muscle fibers (HP:0003200)2.18014735
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17874756
83Poor suck (HP:0002033)2.17701370
84Urinary glycosaminoglycan excretion (HP:0003541)2.15153267
85Mucopolysacchariduria (HP:0008155)2.15153267
86Abnormality of fatty-acid metabolism (HP:0004359)2.11830306
87Respiratory failure (HP:0002878)2.10289266
88Acute hepatic failure (HP:0006554)2.09876302
89Anxiety (HP:0000739)2.09752979
90Tubular atrophy (HP:0000092)2.09410898
91CNS demyelination (HP:0007305)2.09236376
92Asymmetric septal hypertrophy (HP:0001670)2.08215066
93Patellar aplasia (HP:0006443)2.08162317
94Renal Fanconi syndrome (HP:0001994)2.07728633
95Retinal dysplasia (HP:0007973)2.06669667
96Exercise intolerance (HP:0003546)2.06090681
97Agitation (HP:0000713)2.05452681
98Progressive muscle weakness (HP:0003323)2.03909829
99Elevated erythrocyte sedimentation rate (HP:0003565)2.03692240
100Microretrognathia (HP:0000308)2.03308899
101Limb hypertonia (HP:0002509)2.03250642
102Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03175849
103Dysostosis multiplex (HP:0000943)2.02767161
104Metabolic acidosis (HP:0001942)2.02101407
105Cortical visual impairment (HP:0100704)2.01753637
106Broad-based gait (HP:0002136)2.01368027
107Abnormal pupillary function (HP:0007686)2.01079317
108Aplasia/Hypoplasia of the patella (HP:0006498)2.00344767
109Palpitations (HP:0001962)2.00224027
110Type II lissencephaly (HP:0007260)2.00133426
111Polyuria (HP:0000103)1.99967343
112Stomach cancer (HP:0012126)1.98772755
113Chorioretinal atrophy (HP:0000533)1.98248990
114Increased serum lactate (HP:0002151)1.98226656
115Emotional lability (HP:0000712)1.97727111
116Cystic liver disease (HP:0006706)1.97562229
117Clumsiness (HP:0002312)1.97117225
118Abnormality of polysaccharide metabolism (HP:0011012)1.96757018
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96757018
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96757018
121Generalized tonic-clonic seizures (HP:0002069)1.96721465
122Increased corneal curvature (HP:0100692)1.94887734
123Keratoconus (HP:0000563)1.94887734
1243-Methylglutaconic aciduria (HP:0003535)1.93355699
125Muscle stiffness (HP:0003552)1.92926979
126Hyperammonemia (HP:0001987)1.91536828
127Hyperbilirubinemia (HP:0002904)1.90952945
128Oligomenorrhea (HP:0000876)1.90745788
129IgG deficiency (HP:0004315)1.90378995
130Panhypogammaglobulinemia (HP:0003139)1.90311088
131Congenital, generalized hypertrichosis (HP:0004540)1.89884167
132Gaze-evoked nystagmus (HP:0000640)1.89557470
133Rib fusion (HP:0000902)1.88215881
134Congenital hepatic fibrosis (HP:0002612)1.87977360
135Gait imbalance (HP:0002141)1.87572895
136Abnormality of purine metabolism (HP:0004352)1.86310681
137Intrahepatic cholestasis (HP:0001406)1.85061645
138Vacuolated lymphocytes (HP:0001922)1.84687118
139Hyperglycinuria (HP:0003108)1.84080324
140Vomiting (HP:0002013)1.83668147
141Large for gestational age (HP:0001520)1.83643774
142Absent thumb (HP:0009777)1.83508981
143Sclerocornea (HP:0000647)1.82513529
144Hyperphosphaturia (HP:0003109)1.82176215
145Abnormality of serum amino acid levels (HP:0003112)1.82025422
146Supranuclear gaze palsy (HP:0000605)1.81478817
147Absence seizures (HP:0002121)1.80733711
148Cerebral hemorrhage (HP:0001342)1.80469129
149Abnormality of the pancreatic islet cells (HP:0006476)1.80142735
150Abnormality of endocrine pancreas physiology (HP:0012093)1.80142735
151Muscle hypertrophy of the lower extremities (HP:0008968)1.80005404
152Depression (HP:0000716)1.79795258
153Male pseudohermaphroditism (HP:0000037)1.79748192
154Hyperlipoproteinemia (HP:0010980)1.79659209
155Anencephaly (HP:0002323)1.79402452
156Congenital primary aphakia (HP:0007707)1.77528410
157Myotonia (HP:0002486)1.76911394
158Increased hepatocellular lipid droplets (HP:0006565)1.76886381
159Decreased circulating renin level (HP:0003351)1.76238227
160Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76171214
161Status epilepticus (HP:0002133)1.76092003
162Renal cortical cysts (HP:0000803)1.75768657
163Conjunctival hamartoma (HP:0100780)1.75552410
164Lipid accumulation in hepatocytes (HP:0006561)1.74546894
165Abnormality of the prostate (HP:0008775)1.74476747
166Nephrogenic diabetes insipidus (HP:0009806)1.73163813
167Progressive inability to walk (HP:0002505)1.72946177
168Abnormality of the renal collecting system (HP:0004742)1.72902789
169Absent speech (HP:0001344)1.70979454
170Hemiparesis (HP:0001269)1.70476842
171Abnormal ciliary motility (HP:0012262)1.69031587
172Optic nerve hypoplasia (HP:0000609)1.68729377
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.68470739
174Concave nail (HP:0001598)1.68266712
175Hypoplasia of the fovea (HP:0007750)1.67405221
176Aplasia/Hypoplasia of the fovea (HP:0008060)1.67405221
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67089479
178Severe muscular hypotonia (HP:0006829)1.60887434
179Pachygyria (HP:0001302)1.60156514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.11828230
2FRK3.86245973
3BCKDK3.73107289
4MAP4K22.97419903
5TLK12.82348062
6ZAK2.76071755
7SCYL22.60218688
8TXK2.56986651
9BMPR1B2.43731029
10NME12.42339208
11ARAF2.40866165
12ACVR1B2.36981110
13MAP2K42.28533072
14CAMKK22.28437371
15LMTK22.26853173
16NTRK32.17762670
17PHKG22.11737399
18PHKG12.11737399
19GRK12.07967568
20NUAK12.07082638
21ERN11.96249859
22MUSK1.92220461
23FLT31.89301500
24KSR21.88861414
25MAP3K91.86353674
26NTRK11.84416575
27MAP2K71.83451485
28MAPK131.82810201
29MAP3K21.79841377
30NME21.78638081
31MAP3K111.65495758
32MAP3K11.62916440
33MAP3K131.49258549
34MAP2K31.48254980
35ZAP701.46875540
36TAOK31.41495605
37MAPK151.39061279
38WNK31.37608691
39PDK31.35542514
40PDK41.35542514
41WNK41.34934792
42GRK51.34619100
43MINK11.30209737
44OXSR11.28807417
45JAK31.28661805
46INSRR1.24216871
47PASK1.24053440
48PINK11.19340692
49MAP2K61.18493621
50IKBKB1.11959761
51IRAK11.11325985
52TNIK1.10119338
53GRK61.10077551
54HIPK21.09799500
55CDK191.07788839
56GRK71.07601812
57ADRBK11.03644259
58UHMK11.03575744
59VRK11.00403605
60DAPK10.99979457
61SIK20.98849720
62TAOK20.97649678
63IKBKE0.93050036
64VRK20.93019157
65MAP3K40.91794988
66STK390.91190294
67CAMK2G0.91122880
68CAMKK10.91038793
69DYRK20.90728682
70STK160.90543619
71RIPK40.90301208
72TYK20.89930776
73EPHA30.89627351
74FES0.87478776
75ITK0.86862606
76SYK0.85029463
77EIF2AK30.84531074
78PNCK0.84485378
79TAOK10.83531133
80PRKCQ0.81728207
81PRKG20.80017297
82RPS6KA50.79462578
83DAPK20.76778091
84CDK50.75802784
85RAF10.74313327
86TRIB30.72640654
87BRSK20.71872891
88BLK0.70671647
89BTK0.70395638
90MARK10.70045242
91CAMK2D0.69346096
92TEC0.68370573
93BRSK10.68295801
94PTK2B0.66726967
95FGFR40.66278030
96TBK10.64000239
97JAK20.63807248
98CAMK10.62981508
99CAMK2B0.61947082
100OBSCN0.61920697
101TGFBR10.61538672
102STK110.61082793
103CSF1R0.60349410
104MAPKAPK50.59686144
105CAMK1D0.57151585
106RPS6KA60.57056544
107PIK3CA0.57044338
108EPHB10.56955646
109CHUK0.56824339
110LYN0.54768553
111CAMK40.54533037
112IRAK40.54190466
113MKNK20.54143692
114PIK3CG0.53850069
115MAPKAPK30.52693050
116EIF2AK10.51939250
117PRKCG0.51485489
118MYLK0.50926829
119TNK20.50257846
120NTRK20.49686424
121BRAF0.49317425
122MAP2K10.47831711
123LCK0.46860535
124NEK10.46360505
125PRKCE0.44485048
126PIM20.43836459
127MAP4K10.43719891
128TTN0.43042673
129PRKCH0.42987223
130CSNK1G20.42489482
131MAP3K50.42393198
132PAK30.41903543
133ADRBK20.41871683
134LRRK20.41559703
135MAP2K20.41100500
136TRPM70.40276968
137CASK0.39711162
138CSNK1G10.39446464
139RET0.38439603
140MAP3K70.38249547
141CAMK2A0.38171532
142MST40.38076510
143MAPK120.37305628
144NLK0.36856143
145ABL20.36674486
146PRKACA0.35947314
147PIM10.35500448
148PRKACG0.34885334
149MAPK110.34597938
150BMPR20.34577080
151PKN10.34311727
152KIT0.34004596
153PRKCZ0.33727051
154PRKAA20.33314295
155CSNK1G30.33185191

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.26395340
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.19583555
3Protein export_Homo sapiens_hsa030603.06094857
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05281598
5Parkinsons disease_Homo sapiens_hsa050122.88400389
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.62164603
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49513887
8Phototransduction_Homo sapiens_hsa047442.43233670
9Linoleic acid metabolism_Homo sapiens_hsa005912.34498590
10Propanoate metabolism_Homo sapiens_hsa006402.32912915
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21619875
12Nitrogen metabolism_Homo sapiens_hsa009102.18943361
13Alzheimers disease_Homo sapiens_hsa050102.16867726
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.12882451
15Insulin secretion_Homo sapiens_hsa049112.09060693
16Synaptic vesicle cycle_Homo sapiens_hsa047212.05791413
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98201680
18Primary immunodeficiency_Homo sapiens_hsa053401.96164520
19Nicotine addiction_Homo sapiens_hsa050331.94636948
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94133525
21Folate biosynthesis_Homo sapiens_hsa007901.91985395
22Sulfur relay system_Homo sapiens_hsa041221.89182874
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84823936
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83939799
25Sulfur metabolism_Homo sapiens_hsa009201.79672203
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75297391
27Huntingtons disease_Homo sapiens_hsa050161.75051910
28Fatty acid degradation_Homo sapiens_hsa000711.72809587
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.70948953
30Butanoate metabolism_Homo sapiens_hsa006501.67842890
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66135412
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65036020
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61583375
34Vibrio cholerae infection_Homo sapiens_hsa051101.61167322
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59805322
36Collecting duct acid secretion_Homo sapiens_hsa049661.59360603
37Asthma_Homo sapiens_hsa053101.56645532
38Peroxisome_Homo sapiens_hsa041461.52848076
39Pyruvate metabolism_Homo sapiens_hsa006201.48171283
40Cardiac muscle contraction_Homo sapiens_hsa042601.45923282
41Fatty acid elongation_Homo sapiens_hsa000621.42829175
42Cocaine addiction_Homo sapiens_hsa050301.41418246
43Ether lipid metabolism_Homo sapiens_hsa005651.40602657
44beta-Alanine metabolism_Homo sapiens_hsa004101.36831733
45Allograft rejection_Homo sapiens_hsa053301.34765967
46Fatty acid metabolism_Homo sapiens_hsa012121.32351311
47Carbon metabolism_Homo sapiens_hsa012001.29744011
48Graft-versus-host disease_Homo sapiens_hsa053321.29646355
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29177185
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28731846
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25467017
52Autoimmune thyroid disease_Homo sapiens_hsa053201.24252782
53Fanconi anemia pathway_Homo sapiens_hsa034601.21947316
54Homologous recombination_Homo sapiens_hsa034401.20244115
55Arginine biosynthesis_Homo sapiens_hsa002201.18654296
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18277041
57RNA polymerase_Homo sapiens_hsa030201.17046183
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14856030
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12901172
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12379449
61Tryptophan metabolism_Homo sapiens_hsa003801.11104694
62Amphetamine addiction_Homo sapiens_hsa050311.08517959
63Basal transcription factors_Homo sapiens_hsa030221.07979841
64SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03379759
65Arachidonic acid metabolism_Homo sapiens_hsa005901.01943886
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.97779929
67RNA degradation_Homo sapiens_hsa030180.95855312
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94786145
69Other glycan degradation_Homo sapiens_hsa005110.94645282
70Glucagon signaling pathway_Homo sapiens_hsa049220.93643290
71Dopaminergic synapse_Homo sapiens_hsa047280.93416434
72Chemical carcinogenesis_Homo sapiens_hsa052040.92281149
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91882142
74GABAergic synapse_Homo sapiens_hsa047270.90756577
75ABC transporters_Homo sapiens_hsa020100.90314302
76Starch and sucrose metabolism_Homo sapiens_hsa005000.89780044
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88290574
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87747102
79Lysosome_Homo sapiens_hsa041420.85409307
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85178388
81Phenylalanine metabolism_Homo sapiens_hsa003600.83690656
82Thyroid hormone synthesis_Homo sapiens_hsa049180.83162166
83Hematopoietic cell lineage_Homo sapiens_hsa046400.80681224
84Selenocompound metabolism_Homo sapiens_hsa004500.79808973
85Regulation of autophagy_Homo sapiens_hsa041400.79403413
86Dorso-ventral axis formation_Homo sapiens_hsa043200.78287505
87Olfactory transduction_Homo sapiens_hsa047400.77806149
88Histidine metabolism_Homo sapiens_hsa003400.77503639
89Cholinergic synapse_Homo sapiens_hsa047250.77223962
90Rheumatoid arthritis_Homo sapiens_hsa053230.75911307
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74937737
92Retinol metabolism_Homo sapiens_hsa008300.74704260
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73275619
94Biosynthesis of amino acids_Homo sapiens_hsa012300.72791496
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72790723
96Bile secretion_Homo sapiens_hsa049760.71269028
97Glutamatergic synapse_Homo sapiens_hsa047240.68592239
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67093319
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65703487
100Ovarian steroidogenesis_Homo sapiens_hsa049130.65647941
101N-Glycan biosynthesis_Homo sapiens_hsa005100.64757851
102Galactose metabolism_Homo sapiens_hsa000520.64632876
103Type I diabetes mellitus_Homo sapiens_hsa049400.63585628
104Metabolic pathways_Homo sapiens_hsa011000.63203793
105Taste transduction_Homo sapiens_hsa047420.62685036
106Arginine and proline metabolism_Homo sapiens_hsa003300.61164339
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.61114324
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59470577
109PPAR signaling pathway_Homo sapiens_hsa033200.59436635
110Circadian entrainment_Homo sapiens_hsa047130.58868211
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58573207
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57711773
113Tyrosine metabolism_Homo sapiens_hsa003500.56455343
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56295666
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56143471
116Circadian rhythm_Homo sapiens_hsa047100.55086488
117One carbon pool by folate_Homo sapiens_hsa006700.54489966
118Type II diabetes mellitus_Homo sapiens_hsa049300.54067767
119Morphine addiction_Homo sapiens_hsa050320.53979257
120Oxytocin signaling pathway_Homo sapiens_hsa049210.52980848
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52965834
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51188880
123Insulin resistance_Homo sapiens_hsa049310.51069632
124Pancreatic secretion_Homo sapiens_hsa049720.49316167
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49073807
126Renin secretion_Homo sapiens_hsa049240.48802149
127Antigen processing and presentation_Homo sapiens_hsa046120.48777863
128Ribosome_Homo sapiens_hsa030100.47062050
129Pentose phosphate pathway_Homo sapiens_hsa000300.46857604
130Purine metabolism_Homo sapiens_hsa002300.45155803
131Long-term potentiation_Homo sapiens_hsa047200.45062445
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.44644453
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.44419815
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.43849380
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43790823
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.43474298
137Proteasome_Homo sapiens_hsa030500.42383372
138Systemic lupus erythematosus_Homo sapiens_hsa053220.42274795
139Caffeine metabolism_Homo sapiens_hsa002320.42143845
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41642169
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41293704
142cAMP signaling pathway_Homo sapiens_hsa040240.40776824
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.40572793
144Mineral absorption_Homo sapiens_hsa049780.39876465
145Long-term depression_Homo sapiens_hsa047300.38444377
146T cell receptor signaling pathway_Homo sapiens_hsa046600.38418962
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38147168
148Gastric acid secretion_Homo sapiens_hsa049710.36813126
149Staphylococcus aureus infection_Homo sapiens_hsa051500.36532044
150Insulin signaling pathway_Homo sapiens_hsa049100.35944695
151Glycerolipid metabolism_Homo sapiens_hsa005610.35719532
152Serotonergic synapse_Homo sapiens_hsa047260.35433358
153Salivary secretion_Homo sapiens_hsa049700.33369664
154Calcium signaling pathway_Homo sapiens_hsa040200.32001075

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