DUSP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)8.18601470
2neuromuscular process controlling posture (GO:0050884)7.50881603
3response to parathyroid hormone (GO:0071107)6.81977192
4actin-myosin filament sliding (GO:0033275)5.95382386
5muscle filament sliding (GO:0030049)5.95382386
6cellular response to nitric oxide (GO:0071732)5.69807696
7sarcoplasmic reticulum calcium ion transport (GO:0070296)5.40671007
8regulation of glucocorticoid secretion (GO:2000849)5.20594911
9actin-mediated cell contraction (GO:0070252)4.99453909
10sarcomere organization (GO:0045214)4.74565761
11synaptic vesicle exocytosis (GO:0016079)4.44532758
12respiratory system process (GO:0003016)4.41146521
13regulation of corticosteroid hormone secretion (GO:2000846)4.38101923
14myofibril assembly (GO:0030239)4.36040104
15response to nitric oxide (GO:0071731)4.34706154
16regulation of synaptic vesicle exocytosis (GO:2000300)4.21577185
17negative regulation of amino acid transport (GO:0051956)4.20513872
18labyrinthine layer development (GO:0060711)4.20407140
19regulation of relaxation of muscle (GO:1901077)4.19244121
20cardiac muscle contraction (GO:0060048)4.17317710
21striated muscle contraction (GO:0006941)4.12878692
22cellular response to reactive nitrogen species (GO:1902170)4.09368346
23regulation of energy homeostasis (GO:2000505)4.04805275
24melanin biosynthetic process (GO:0042438)4.03141288
25cardiac myofibril assembly (GO:0055003)3.98436274
26skeletal muscle contraction (GO:0003009)3.97244227
27regulation of skeletal muscle contraction (GO:0014819)3.95384490
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.94050835
29synaptic vesicle maturation (GO:0016188)3.89840443
30response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.86160495
31actin filament-based movement (GO:0030048)3.84660073
32ATP hydrolysis coupled proton transport (GO:0015991)3.76849247
33energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.76849247
34regulation of glutamate secretion (GO:0014048)3.76464050
35creatine metabolic process (GO:0006600)3.76043839
36glutamate secretion (GO:0014047)3.74361036
37melanin metabolic process (GO:0006582)3.73361718
38response to muscle activity (GO:0014850)3.71001708
39short-term memory (GO:0007614)3.70383388
40regulation of cell communication by electrical coupling (GO:0010649)3.67410429
41regulation of actin filament-based movement (GO:1903115)3.63575925
42regulation of short-term neuronal synaptic plasticity (GO:0048172)3.60493114
43regulation of synaptic vesicle transport (GO:1902803)3.57118168
44actomyosin structure organization (GO:0031032)3.54007334
45transferrin transport (GO:0033572)3.53405808
46C4-dicarboxylate transport (GO:0015740)3.52265169
47NADH metabolic process (GO:0006734)3.48311511
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42584500
49detection of temperature stimulus involved in sensory perception (GO:0050961)3.40989326
50detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.40989326
51iron coordination entity transport (GO:1901678)3.39272040
52response to hyperoxia (GO:0055093)3.36746576
53response to increased oxygen levels (GO:0036296)3.36746576
54cardiac muscle hypertrophy (GO:0003300)3.31905951
55ferric iron transport (GO:0015682)3.28107466
56trivalent inorganic cation transport (GO:0072512)3.28107466
57response to pheromone (GO:0019236)3.19520523
58activation of protein kinase A activity (GO:0034199)3.17787968
59negative regulation of dendrite morphogenesis (GO:0050774)3.17013009
60adult feeding behavior (GO:0008343)3.16675720
61regulation of the force of heart contraction (GO:0002026)3.16637749
62muscle contraction (GO:0006936)3.16100672
63glycogen catabolic process (GO:0005980)3.16099994
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.14711043
65macroautophagy (GO:0016236)3.14388809
66striated muscle hypertrophy (GO:0014897)3.13186212
67plasma membrane repair (GO:0001778)3.12480023
68adult walking behavior (GO:0007628)3.11802861
69negative regulation of metanephros development (GO:0072217)3.11271108
70secondary metabolite biosynthetic process (GO:0044550)3.09231195
71response to acidic pH (GO:0010447)3.09008659
72positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.05447620
73negative regulation of neurotransmitter secretion (GO:0046929)3.02608280
74carnitine shuttle (GO:0006853)3.01160124
75response to inactivity (GO:0014854)3.00684086
76positive regulation of autophagy (GO:0010508)3.00210387
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96810500
78protein localization to synapse (GO:0035418)2.95154380
79regulation of steroid hormone secretion (GO:2000831)2.93875320
80cullin deneddylation (GO:0010388)2.93590440
81glucan catabolic process (GO:0009251)2.93513052
82neurotransmitter-gated ion channel clustering (GO:0072578)2.92567704
83regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.92268534
84SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.91929879
85membrane depolarization during action potential (GO:0086010)2.91848789
86neurotransmitter secretion (GO:0007269)2.91134136
87muscle system process (GO:0003012)2.88090664
88regulation of striated muscle contraction (GO:0006942)2.85777029
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.85243064
90muscle hypertrophy (GO:0014896)2.84552202
91cellular polysaccharide catabolic process (GO:0044247)2.83322705
92dicarboxylic acid biosynthetic process (GO:0043650)2.83085852
93positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82469613
94detection of temperature stimulus (GO:0016048)2.79861869
95regulation of transforming growth factor beta1 production (GO:0032908)2.78970115
96amino acid salvage (GO:0043102)2.78656096
97L-methionine salvage (GO:0071267)2.78656096
98L-methionine biosynthetic process (GO:0071265)2.78656096
99regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.78452963
100locomotory exploration behavior (GO:0035641)2.77447771
101calcium-mediated signaling using intracellular calcium source (GO:0035584)2.77240575
102neuronal action potential (GO:0019228)2.76959289
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.76593426
104negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.75360268
105regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74554807
106cardiac muscle tissue morphogenesis (GO:0055008)2.74189320
107regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.74047647
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74037584
109regulation of appetite (GO:0032098)2.70960840
110cell communication by electrical coupling (GO:0010644)2.69651356
111relaxation of cardiac muscle (GO:0055119)2.69610942
112regulation of glutamate receptor signaling pathway (GO:1900449)2.69001939
113positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67737631
114muscle cell cellular homeostasis (GO:0046716)2.67661496
115regulation of calcium ion transmembrane transport (GO:1903169)2.66030752
116regulation of calcium ion transmembrane transporter activity (GO:1901019)2.66030752
117regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.65969186
118phagosome maturation (GO:0090382)2.65959304
119skeletal muscle fiber development (GO:0048741)2.64370219
120axonal fasciculation (GO:0007413)2.64161083
121muscle tissue morphogenesis (GO:0060415)2.63620360
122regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63377604
123tricarboxylic acid cycle (GO:0006099)2.62762562
124gluconeogenesis (GO:0006094)2.62358830
125negative regulation of protein localization to cell surface (GO:2000009)2.62343610
126clathrin coat assembly (GO:0048268)2.61676325
127proteasome assembly (GO:0043248)2.61329659
128cell communication involved in cardiac conduction (GO:0086065)2.61086170
129vocalization behavior (GO:0071625)2.60783993
130polysaccharide catabolic process (GO:0000272)2.60341616
131protein deneddylation (GO:0000338)2.60296872
132fatty acid transmembrane transport (GO:1902001)2.59085784
133regulation of amino acid transport (GO:0051955)2.57560008
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57498682
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56859034
136membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56201099
137L-phenylalanine metabolic process (GO:0006558)2.55125349
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.55125349
139positive regulation of gluconeogenesis (GO:0045722)2.55075233
140negative regulation of organic acid transport (GO:0032891)2.54480753
141heart contraction (GO:0060047)2.54404593
142heart process (GO:0003015)2.54404593
143synaptic transmission, glutamatergic (GO:0035249)2.51834315
144regulation of neurotransmitter secretion (GO:0046928)2.51565603
145regulation of synapse structural plasticity (GO:0051823)2.50205395
146cardiac muscle adaptation (GO:0014887)2.49829418
147cardiac muscle hypertrophy in response to stress (GO:0014898)2.49829418
148muscle hypertrophy in response to stress (GO:0003299)2.49829418
149relaxation of muscle (GO:0090075)2.49788007
150negative regulation of neurotransmitter transport (GO:0051589)2.48298165
151negative regulation of cation channel activity (GO:2001258)2.48057729
152regulation of feeding behavior (GO:0060259)2.48012513
153negative regulation of amine transport (GO:0051953)2.45832153
154fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45723521
155response to epinephrine (GO:0071871)2.45244331
156regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.43654416
157ADP metabolic process (GO:0046031)2.43168280
158positive regulation of membrane potential (GO:0045838)2.42867901
159positive regulation of amino acid transport (GO:0051957)2.41707759
160presynaptic membrane organization (GO:0097090)2.41378441
161myotube cell development (GO:0014904)2.40929713
162negative regulation of fibrinolysis (GO:0051918)2.40631715
163cardiac muscle cell development (GO:0055013)2.40609493
164potassium ion export (GO:0071435)2.39985900
165hexose biosynthetic process (GO:0019319)2.39783229
166adult heart development (GO:0007512)2.39308272
167striated muscle adaptation (GO:0014888)2.35681950
168negative regulation of potassium ion transmembrane transport (GO:1901380)2.35660733
169fructose metabolic process (GO:0006000)2.35311720
170negative regulation of calcium ion transmembrane transport (GO:1903170)2.33562172
171negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.33562172
172negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.32409551
173detection of calcium ion (GO:0005513)2.31800063
174positive regulation of receptor recycling (GO:0001921)2.31353415
175peptidyl-glutamic acid carboxylation (GO:0017187)2.29806404
176protein carboxylation (GO:0018214)2.29806404
177skeletal muscle adaptation (GO:0043501)2.26740937
178regulation of fibrinolysis (GO:0051917)2.26661241
179ventricular cardiac muscle cell action potential (GO:0086005)2.26069909
180erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.25807414
181L-phenylalanine catabolic process (GO:0006559)2.25807414
182glucan biosynthetic process (GO:0009250)2.25744357
183glycogen biosynthetic process (GO:0005978)2.25744357
184response to mercury ion (GO:0046689)2.25562888
185regulation of cardiac muscle contraction (GO:0055117)2.23544474
186ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.22813190
187regulation of protein activation cascade (GO:2000257)2.22675836
188cellular potassium ion homeostasis (GO:0030007)2.22632989
189cellular response to epinephrine stimulus (GO:0071872)2.22226954
190cardiac cell development (GO:0055006)2.20989231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42634237
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.54761897
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.50251404
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.21478882
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.90998261
6GBX2_23144817_ChIP-Seq_PC3_Human2.86463787
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.67596335
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61616892
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.47098827
10REST_21632747_ChIP-Seq_MESCs_Mouse2.46468800
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43385651
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.36099288
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.31823861
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28534612
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.28160124
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27337328
17* RARB_27405468_Chip-Seq_BRAIN_Mouse2.21796401
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.19121043
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17968012
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.16848066
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16703167
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16570715
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14718563
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.11647285
25TBX20_22080862_ChIP-Seq_HEART_Mouse2.07141122
26TBX20_22328084_ChIP-Seq_HEART_Mouse2.07141122
27CLOCK_20551151_ChIP-Seq_293T_Human1.95122707
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91878974
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87878043
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85681745
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84758537
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84624589
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.84232308
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.83391984
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77780511
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75198673
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72329294
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72329294
39SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.70250534
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69934557
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66885991
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.66091505
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63749692
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.63068678
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.62632156
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61882178
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60436984
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58569843
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56901655
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.56284555
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.55294211
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.54871260
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51675030
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.51362105
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48828145
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.45896137
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.45749594
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44201837
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44037050
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42213841
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41561248
62* FOXA2_19822575_ChIP-Seq_HepG2_Human1.40895864
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40456027
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36169118
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34632283
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34290091
67MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33194832
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32666471
69* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31609481
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31490968
71* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30933956
72ZNF263_19887448_ChIP-Seq_K562_Human1.29720170
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28756652
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28352161
75AR_21572438_ChIP-Seq_LNCaP_Human1.28032888
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27906364
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27749384
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25145627
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25145627
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23085790
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22500295
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22379594
83VDR_22108803_ChIP-Seq_LS180_Human1.20177514
84LXR_22292898_ChIP-Seq_THP-1_Human1.14642424
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13542094
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12769046
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12665970
88TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11665819
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11019458
90CJUN_26792858_Chip-Seq_BT549_Human1.09895136
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09101072
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08787475
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08770660
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06956700
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06519131
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06415449
97* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06332124
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06049583
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.05509066
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03721867
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02118970
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.01683883
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01259317
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00894335
105GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98883424
106* RACK7_27058665_Chip-Seq_MCF-7_Human0.98016917
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97826087
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97244423
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96126662
110RNF2_27304074_Chip-Seq_ESCs_Mouse0.95902990
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95698185
112REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94484093
113EOMES_21245162_ChIP-Seq_HESCs_Human0.93544182
114SOX2_20726797_ChIP-Seq_SW620_Human0.91730121
115CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91307559
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91301062
117* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91282483
118TP53_23651856_ChIP-Seq_MEFs_Mouse0.89773014
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89751045
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88699876
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88584819
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88119175
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87898744
124P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87031579
125AR_25329375_ChIP-Seq_VCAP_Human0.87026848
126CTCF_27219007_Chip-Seq_Bcells_Human0.86713700
127TAF15_26573619_Chip-Seq_HEK293_Human0.86648058
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86407204
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86142764
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85039653
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84088709
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84070851
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83569685
134SMC4_20622854_ChIP-Seq_HELA_Human0.82963134
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82909830
136CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82178729
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82099423
138IRF1_19129219_ChIP-ChIP_H3396_Human0.82049215
139WT1_19549856_ChIP-ChIP_CCG9911_Human0.81907069
140ERA_21632823_ChIP-Seq_H3396_Human0.81885379
141SRF_21415370_ChIP-Seq_HL-1_Mouse0.81850324
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81678537
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81663500
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.81624232
145MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80735297
146SMAD4_21799915_ChIP-Seq_A2780_Human0.80395726
147BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79572688
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79436762
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78216199
150* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77702137
151* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.77635413
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77632441
153JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77202955
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.76534090
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76417086
156SMC1_22415368_ChIP-Seq_MEFs_Mouse0.74554575
157FOXH1_21741376_ChIP-Seq_ESCs_Human0.73708403
158* HNF4A_19822575_ChIP-Seq_HepG2_Human0.73700238
159TAF2_19829295_ChIP-Seq_ESCs_Human0.73411660
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73354473
161DROSHA_22980978_ChIP-Seq_HELA_Human0.72198594
162KDM2B_26808549_Chip-Seq_K562_Human0.72077380
163* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71451473
164KLF4_19829295_ChIP-Seq_ESCs_Human0.71093394
165* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70644578
166RBPJ_21746931_ChIP-Seq_IB4_Human0.69140539
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.69094729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception4.19431833
2MP0003122_maternal_imprinting3.82661567
3MP0004859_abnormal_synaptic_plasticity3.66404588
4MP0003123_paternal_imprinting3.46377732
5MP0003880_abnormal_central_pattern3.42511856
6MP0008260_abnormal_autophagy3.31383152
7MP0000751_myopathy2.79008157
8MP0004270_analgesia2.70091173
9MP0003635_abnormal_synaptic_transmissio2.69342995
10MP0006276_abnormal_autonomic_nervous2.66974007
11MP0004087_abnormal_muscle_fiber2.59387927
12MP0002064_seizures2.56867736
13MP0004510_myositis2.49591736
14MP0009745_abnormal_behavioral_response2.36519565
15MP0001986_abnormal_taste_sensitivity2.32696714
16MP0002106_abnormal_muscle_physiology2.31303053
17MP0002736_abnormal_nociception_after2.30388730
18MP0009046_muscle_twitch2.29968298
19MP0009780_abnormal_chondrocyte_physiolo2.24665947
20MP0002139_abnormal_hepatobiliary_system2.23723848
21MP0002272_abnormal_nervous_system2.23316311
22MP0002735_abnormal_chemical_nociception2.20282363
23MP0002067_abnormal_sensory_capabilities2.13848917
24MP0002734_abnormal_mechanical_nocicepti2.12811026
25MP0000759_abnormal_skeletal_muscle2.10224614
26MP0005423_abnormal_somatic_nervous2.08795566
27MP0001188_hyperpigmentation2.06991063
28MP0002063_abnormal_learning/memory/cond1.92985886
29MP0002822_catalepsy1.91735038
30MP0005369_muscle_phenotype1.90252770
31MP0003121_genomic_imprinting1.88918885
32MP0000750_abnormal_muscle_regeneration1.88044146
33MP0002837_dystrophic_cardiac_calcinosis1.87441683
34MP0003646_muscle_fatigue1.85874043
35MP0001970_abnormal_pain_threshold1.84118405
36MP0004142_abnormal_muscle_tone1.79078849
37MP0002733_abnormal_thermal_nociception1.76275085
38MP0006138_congestive_heart_failure1.73049096
39MP0005645_abnormal_hypothalamus_physiol1.71207395
40MP0002572_abnormal_emotion/affect_behav1.70588229
41MP0001905_abnormal_dopamine_level1.61779705
42MP0001661_extended_life_span1.61652306
43MP0000749_muscle_degeneration1.58920553
44MP0005167_abnormal_blood-brain_barrier1.54958573
45MP0010630_abnormal_cardiac_muscle1.54714679
46MP0001440_abnormal_grooming_behavior1.54457288
47MP0003950_abnormal_plasma_membrane1.53928823
48MP0005165_increased_susceptibility_to1.52894947
49MP0005058_abnormal_lysosome_morphology1.52217061
50MP0001501_abnormal_sleep_pattern1.45898619
51MP0005385_cardiovascular_system_phenoty1.42804499
52MP0001544_abnormal_cardiovascular_syste1.42804499
53MP0004036_abnormal_muscle_relaxation1.42654880
54MP0005409_darkened_coat_color1.40780933
55MP0000747_muscle_weakness1.40623318
56MP0004084_abnormal_cardiac_muscle1.36486396
57MP0004130_abnormal_muscle_cell1.36224265
58MP0005365_abnormal_bile_salt1.36091223
59MP0008775_abnormal_heart_ventricle1.34260888
60MP0001727_abnormal_embryo_implantation1.30244011
61MP0002909_abnormal_adrenal_gland1.29536812
62MP0005084_abnormal_gallbladder_morpholo1.27609431
63MP0004924_abnormal_behavior1.27582019
64MP0005386_behavior/neurological_phenoty1.27582019
65MP0000733_abnormal_muscle_development1.27439388
66MP0002876_abnormal_thyroid_physiology1.27097848
67MP0000003_abnormal_adipose_tissue1.27010477
68MP0000013_abnormal_adipose_tissue1.25720617
69MP0002638_abnormal_pupillary_reflex1.25253911
70MP0003172_abnormal_lysosome_physiology1.21755058
71MP0005670_abnormal_white_adipose1.21322770
72MP0001486_abnormal_startle_reflex1.20105616
73MP0004811_abnormal_neuron_physiology1.18018566
74MP0002971_abnormal_brown_adipose1.17562631
75MP0003191_abnormal_cellular_cholesterol1.17452197
76MP0003566_abnormal_cell_adhesion1.17189640
77MP0003690_abnormal_glial_cell1.16962452
78MP0002751_abnormal_autonomic_nervous1.16684979
79MP0005623_abnormal_meninges_morphology1.15683052
80MP0003075_altered_response_to1.12929630
81MP0008438_abnormal_cutaneous_collagen1.12890262
82MP0003137_abnormal_impulse_conducting1.10969300
83MP0000604_amyloidosis1.09980764
84MP0002127_abnormal_cardiovascular_syste1.09638666
85MP0002066_abnormal_motor_capabilities/c1.08890061
86MP0000343_altered_response_to1.07974981
87MP0003828_pulmonary_edema1.07269619
88MP0009379_abnormal_foot_pigmentation1.07102852
89MP0002184_abnormal_innervation1.06927873
90MP0003705_abnormal_hypodermis_morpholog1.06372020
91MP0004484_altered_response_of1.06182389
92MP0010329_abnormal_lipoprotein_level1.05801887
93MP0009840_abnormal_foam_cell1.02512663
94MP0003879_abnormal_hair_cell1.00985526
95MP0003633_abnormal_nervous_system0.99092458
96MP0002108_abnormal_muscle_morphology0.98575418
97MP0001984_abnormal_olfaction0.98574616
98MP0003329_amyloid_beta_deposits0.97290668
99MP0002557_abnormal_social/conspecific_i0.96545104
100MP0005375_adipose_tissue_phenotype0.96384642
101MP0002877_abnormal_melanocyte_morpholog0.94840469
102MP0008569_lethality_at_weaning0.94285022
103MP0005330_cardiomyopathy0.93098591
104MP0002332_abnormal_exercise_endurance0.92543044
105MP0003136_yellow_coat_color0.91126854
106MP0004233_abnormal_muscle_weight0.90355190
107MP0004145_abnormal_muscle_electrophysio0.90238225
108MP0001502_abnormal_circadian_rhythm0.90146594
109MP0005448_abnormal_energy_balance0.89005457
110MP0002269_muscular_atrophy0.88981175
111MP0002229_neurodegeneration0.88881475
112MP0002896_abnormal_bone_mineralization0.88160798
113MP0004215_abnormal_myocardial_fiber0.87411555
114MP0010368_abnormal_lymphatic_system0.85533929
115MP0002882_abnormal_neuron_morphology0.85331224
116MP0005535_abnormal_body_temperature0.84612492
117MP0005085_abnormal_gallbladder_physiolo0.84565808
118MP0000230_abnormal_systemic_arterial0.84440598
119MP0003279_aneurysm0.84154462
120MP0006035_abnormal_mitochondrial_morpho0.83894400
121MP0002118_abnormal_lipid_homeostasis0.83753016
122MP0005595_abnormal_vascular_smooth0.82909095
123MP0006292_abnormal_olfactory_placode0.81372458
124MP0009333_abnormal_splenocyte_physiolog0.80385093
125MP0003091_abnormal_cell_migration0.79863242
126MP0005332_abnormal_amino_acid0.79836890
127MP0005408_hypopigmentation0.79600077
128MP0000920_abnormal_myelination0.78469721
129MP0003631_nervous_system_phenotype0.76263189
130MP0003195_calcinosis0.76249099
131MP0005666_abnormal_adipose_tissue0.74628855
132MP0005257_abnormal_intraocular_pressure0.73963352
133MP0006036_abnormal_mitochondrial_physio0.73901104
134MP0002069_abnormal_eating/drinking_beha0.73512909
135MP0001958_emphysema0.73408371
136MP0004272_abnormal_basement_membrane0.73241266
137MP0008875_abnormal_xenobiotic_pharmacok0.70964052
138MP0003868_abnormal_feces_composition0.70319971
139MP0000639_abnormal_adrenal_gland0.70117841
140MP0005166_decreased_susceptibility_to0.69922130
141MP0003634_abnormal_glial_cell0.69562416
142MP0002972_abnormal_cardiac_muscle0.69344656
143MP0005620_abnormal_muscle_contractility0.68843088
144MP0005584_abnormal_enzyme/coenzyme_acti0.68727130
145MP0003045_fibrosis0.68310799
146MP0003806_abnormal_nucleotide_metabolis0.68285148
147MP0000778_abnormal_nervous_system0.67639228
148MP0000767_abnormal_smooth_muscle0.67538935
149MP0004858_abnormal_nervous_system0.67505483
150MP0001542_abnormal_bone_strength0.67331115
151MP0008874_decreased_physiological_sensi0.67212732
152MP0001756_abnormal_urination0.65294133
153MP0005266_abnormal_metabolism0.65279168
154MP0004085_abnormal_heartbeat0.64992566
155MP0010234_abnormal_vibrissa_follicle0.64983031
156MP0002295_abnormal_pulmonary_circulatio0.64966294
157MP0005248_abnormal_Harderian_gland0.64509702
158MP0005451_abnormal_body_composition0.64478467
159MP0009672_abnormal_birth_weight0.63984154
160MP0005187_abnormal_penis_morphology0.63663766
161MP0002128_abnormal_blood_circulation0.63563334
162MP0000372_irregular_coat_pigmentation0.62793568
163MP0005171_absent_coat_pigmentation0.61010892
164MP0001849_ear_inflammation0.60905096

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.59205518
2Muscle fiber inclusion bodies (HP:0100299)6.80374752
3Nemaline bodies (HP:0003798)6.74457755
4Atonic seizures (HP:0010819)6.69907911
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.65669383
6Type 1 muscle fiber predominance (HP:0003803)5.68255311
7Failure to thrive in infancy (HP:0001531)5.00839430
8Polyphagia (HP:0002591)5.00529475
9Myokymia (HP:0002411)4.82727280
10Febrile seizures (HP:0002373)4.77867505
11Hyporeflexia of lower limbs (HP:0002600)4.66613077
12Exercise-induced muscle cramps (HP:0003710)4.62208464
13Oligomenorrhea (HP:0000876)4.58295391
14Asymmetric septal hypertrophy (HP:0001670)4.47207129
15Hypoglycemic seizures (HP:0002173)4.37425180
16Absence seizures (HP:0002121)4.34532560
17Focal seizures (HP:0007359)4.29332200
18EMG: myopathic abnormalities (HP:0003458)4.27312442
19Abnormal hair whorl (HP:0010721)4.26306304
20Hemiplegia (HP:0002301)4.07060708
21Muscle hypertrophy of the lower extremities (HP:0008968)4.03296702
22Dialeptic seizures (HP:0011146)3.91105698
23Distal lower limb muscle weakness (HP:0009053)3.87958565
24Abnormality of the calf musculature (HP:0001430)3.81339824
25Calf muscle hypertrophy (HP:0008981)3.80383620
26Abnormal eating behavior (HP:0100738)3.62684707
27Double outlet right ventricle (HP:0001719)3.62168431
28Congenital malformation of the right heart (HP:0011723)3.62168431
29Abnormality of the labia minora (HP:0012880)3.57882855
30Centrally nucleated skeletal muscle fibers (HP:0003687)3.54206685
31Myoglobinuria (HP:0002913)3.49601896
32Rhabdomyolysis (HP:0003201)3.45071579
33Abnormality of skeletal muscle fiber size (HP:0012084)3.44645040
34Ventricular tachycardia (HP:0004756)3.41778758
35Subaortic stenosis (HP:0001682)3.38945164
36Abnormality of the left ventricular outflow tract (HP:0011103)3.38945164
37Distal arthrogryposis (HP:0005684)3.32115709
38Epileptic encephalopathy (HP:0200134)3.30495894
39Neck muscle weakness (HP:0000467)3.28743265
40Increased connective tissue (HP:0009025)3.26761384
41Myopathic facies (HP:0002058)3.22682669
42Status epilepticus (HP:0002133)3.22550563
43Increased variability in muscle fiber diameter (HP:0003557)3.21758754
44Ulnar deviation of the wrist (HP:0003049)3.19265657
45Cortical visual impairment (HP:0100704)3.18826365
46Generalized tonic-clonic seizures (HP:0002069)3.12469612
47Sleep apnea (HP:0010535)3.09369874
48Round ear (HP:0100830)3.06231141
49Heart block (HP:0012722)3.05189773
50Abnormal atrioventricular conduction (HP:0005150)3.04571914
51Difficulty running (HP:0009046)2.95873765
52Poor suck (HP:0002033)2.92030042
53Retinal dysplasia (HP:0007973)2.88261203
54Distal lower limb amyotrophy (HP:0008944)2.85722882
55Rimmed vacuoles (HP:0003805)2.85078705
56Hemiparesis (HP:0001269)2.84168039
57Frequent falls (HP:0002359)2.82051570
58Symptomatic seizures (HP:0011145)2.77314300
59Postnatal microcephaly (HP:0005484)2.75493982
60Dilated cardiomyopathy (HP:0001644)2.75105335
61Lipoatrophy (HP:0100578)2.71092303
62Type II lissencephaly (HP:0007260)2.70141884
63Cerebral hypomyelination (HP:0006808)2.68664191
64Abnormality of pain sensation (HP:0010832)2.67974380
65Impaired pain sensation (HP:0007328)2.67974380
66Mildly elevated creatine phosphokinase (HP:0008180)2.65209675
67Generalized myoclonic seizures (HP:0002123)2.64997924
68Ventricular arrhythmia (HP:0004308)2.61479663
69Atrial fibrillation (HP:0005110)2.54463219
70Muscle fiber splitting (HP:0003555)2.53356967
71EMG: neuropathic changes (HP:0003445)2.49820605
72Atrioventricular block (HP:0001678)2.49298798
73Hyperventilation (HP:0002883)2.47145416
74Generalized hypotonia (HP:0001290)2.41813488
75Hypoventilation (HP:0002791)2.38203210
76Rhabdomyosarcoma (HP:0002859)2.37498943
77Delusions (HP:0000746)2.34998560
78Syncope (HP:0001279)2.34895721
79Deep venous thrombosis (HP:0002625)2.34793649
80Spinal rigidity (HP:0003306)2.33521709
81Muscle stiffness (HP:0003552)2.33182325
82Primary atrial arrhythmia (HP:0001692)2.30542603
83Lower limb amyotrophy (HP:0007210)2.30453504
84Action tremor (HP:0002345)2.30005102
85Pheochromocytoma (HP:0002666)2.28113808
86Patent foramen ovale (HP:0001655)2.23871486
87Generalized muscle weakness (HP:0003324)2.23836200
88Decreased muscle mass (HP:0003199)2.23098731
89Supraventricular tachycardia (HP:0004755)2.22927937
90Scapular winging (HP:0003691)2.22134788
91Supraventricular arrhythmia (HP:0005115)2.21603946
92Areflexia of lower limbs (HP:0002522)2.21172391
93Complement deficiency (HP:0004431)2.20612599
94Right ventricular cardiomyopathy (HP:0011663)2.20196513
95Methylmalonic aciduria (HP:0012120)2.18781077
96Abnormal umbilical cord blood vessels (HP:0011403)2.14807927
97Single umbilical artery (HP:0001195)2.14807927
98Abnormality of the fetal cardiovascular system (HP:0010948)2.14807927
99Hypercortisolism (HP:0001578)2.14796578
100Abnormality of the foot musculature (HP:0001436)2.12261910
101Esotropia (HP:0000565)2.10773703
102Bulbar palsy (HP:0001283)2.10436366
103Ventricular fibrillation (HP:0001663)2.08879370
104Foot dorsiflexor weakness (HP:0009027)2.08538933
105Unsteady gait (HP:0002317)2.06720948
106Growth hormone excess (HP:0000845)2.06402629
107Neuroendocrine neoplasm (HP:0100634)2.04439550
108Truncus arteriosus (HP:0001660)2.04190326
109Mitral stenosis (HP:0001718)2.02925701
110Abnormality of glycolysis (HP:0004366)2.02650220
111Increased serum pyruvate (HP:0003542)2.02650220
112Supranuclear gaze palsy (HP:0000605)2.01949185
113Limb-girdle muscle atrophy (HP:0003797)1.99919261
114Calcaneovalgus deformity (HP:0001848)1.98664329
115Myotonia (HP:0002486)1.98336846
116Neurofibrillary tangles (HP:0002185)1.96938287
117Hip dysplasia (HP:0001385)1.95788946
118Gowers sign (HP:0003391)1.95198797
119Hypoalphalipoproteinemia (HP:0003233)1.94394199
120Systemic lupus erythematosus (HP:0002725)1.93241050
121Abnormality of the Achilles tendon (HP:0005109)1.92853012
122Spastic paraparesis (HP:0002313)1.91691521
123Bundle branch block (HP:0011710)1.90774385
124Narrow nasal bridge (HP:0000446)1.90630199
125Absent phalangeal crease (HP:0006109)1.90579803
126Difficulty climbing stairs (HP:0003551)1.90128311
127Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89786012
128Urinary glycosaminoglycan excretion (HP:0003541)1.89598419
129Mucopolysacchariduria (HP:0008155)1.89598419
130Progressive cerebellar ataxia (HP:0002073)1.89554785
131Diaphragmatic weakness (HP:0009113)1.88378571
132Acute necrotizing encephalopathy (HP:0006965)1.88085773
133Abnormality of the aortic arch (HP:0012303)1.87766194
134Anomalous pulmonary venous return (HP:0010772)1.87744084
135Vascular calcification (HP:0004934)1.87036431
136Abnormality of polysaccharide metabolism (HP:0011012)1.85853220
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85853220
138Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85853220
139Skin nodule (HP:0200036)1.84484034
140Ragged-red muscle fibers (HP:0003200)1.84387747
141Nasal speech (HP:0001611)1.83022438
142Cardiovascular calcification (HP:0011915)1.82724416
143Cerebral inclusion bodies (HP:0100314)1.81519168
144Xanthomatosis (HP:0000991)1.81477030
145Hyperglycinemia (HP:0002154)1.80825591
146Abnormality of the umbilical cord (HP:0010881)1.80733159
147Joint hemorrhage (HP:0005261)1.79355222
148Exercise-induced myalgia (HP:0003738)1.78934304
149Progressive external ophthalmoplegia (HP:0000590)1.78355540
150Dysostosis multiplex (HP:0000943)1.78027361
151Abnormality of complement system (HP:0005339)1.77890934
152Abnormality of liposaccharide metabolism (HP:0010968)1.76426354
153Abnormality of glycosphingolipid metabolism (HP:0004343)1.76426354
154Abnormality of glycolipid metabolism (HP:0010969)1.76426354
155Scanning speech (HP:0002168)1.75757007
156Achilles tendon contracture (HP:0001771)1.74691886
157Abnormality of magnesium homeostasis (HP:0004921)1.74349126
158Deformed tarsal bones (HP:0008119)1.72633338
159Visual hallucinations (HP:0002367)1.71415827
160Cerebral aneurysm (HP:0004944)1.71222549
161Protrusio acetabuli (HP:0003179)1.70405302
162Muscular dystrophy (HP:0003560)1.70349038
163Palpitations (HP:0001962)1.69944536
164Dysmetria (HP:0001310)1.69632459
165Abnormality of the pulmonary veins (HP:0011718)1.69286845
166Ankle clonus (HP:0011448)1.68842335
167Abnormality of the anterior horn cell (HP:0006802)1.68375857
168Degeneration of anterior horn cells (HP:0002398)1.68375857
169Hepatocellular necrosis (HP:0001404)1.68137604
170Depression (HP:0000716)1.66095289
171Abnormal mitochondria in muscle tissue (HP:0008316)1.65710663
172Emotional lability (HP:0000712)1.65507811
173Abnormality of alanine metabolism (HP:0010916)1.65355524
174Hyperalaninemia (HP:0003348)1.65355524
175Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65355524
176Rapidly progressive (HP:0003678)1.64795050
177Testicular atrophy (HP:0000029)1.64778580
178Vertebral compression fractures (HP:0002953)1.62731070
179Malignant hyperthermia (HP:0002047)1.61351951
180Axonal loss (HP:0003447)1.60389809
181Psychosis (HP:0000709)1.60155515
182Steppage gait (HP:0003376)1.58578087
183Sudden death (HP:0001699)1.58074218
184Abnormal EKG (HP:0003115)1.57789352
185Methylmalonic acidemia (HP:0002912)1.57552961
186Broad distal phalanx of finger (HP:0009836)1.56506168
187Abnormal pupillary function (HP:0007686)1.53845781
188Progressive muscle weakness (HP:0003323)1.51087251
189Progressive neurologic deterioration (HP:0002344)1.50657020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.22779520
2TTN4.94421070
3NLK4.73646434
4CASK4.42409573
5ARAF3.75830409
6SGK23.18791195
7SGK4942.85794618
8SGK2232.85794618
9MAP3K92.63097791
10NME22.56290581
11PHKG12.28705115
12PHKG22.28705115
13AKT32.23457816
14RIPK12.22827018
15CSNK1G12.21807860
16MAP2K72.17745082
17SGK32.14207374
18DMPK2.03329694
19MAP3K122.02237585
20NTRK32.01429908
21BRAF1.99868014
22LIMK11.96372709
23CCNB11.93337184
24CDK191.84599710
25DYRK1A1.63281961
26LMTK21.62136152
27DAPK21.60807765
28MAP3K41.60712546
29ICK1.59662722
30CAMKK21.55408320
31BUB11.51562825
32IRAK31.48124591
33MAPKAPK31.45262082
34KSR21.44768061
35PIK3CG1.43620258
36PRPF4B1.41093409
37EPHA41.38812777
38MAP2K31.32987957
39PINK11.30514872
40MUSK1.30365586
41TGFBR21.28444552
42BCKDK1.28330458
43MARK11.26293134
44MINK11.23520091
45TRPM71.23213984
46NEK91.23199718
47NTRK11.22942375
48PLK21.20925844
49MAP2K41.16354692
50PDK31.15486595
51PDK41.15486595
52PDK21.13867923
53TESK11.12055487
54MAP3K11.11700219
55NME11.11194843
56TRIB31.09268145
57TAOK11.09088948
58DDR21.07085718
59PDGFRA1.02734947
60PAK61.00389967
61OXSR10.99867091
62CAMK2D0.99048536
63MAP3K30.97509011
64LATS20.95547186
65PIK3CA0.94836074
66EPHB10.92329352
67PRKAA20.92166726
68PRKD30.90555118
69MAP3K110.89415431
70MAP3K70.85368855
71PAK10.83742098
72GRK50.82321280
73ABL20.81253172
74PDPK10.80481557
75CDK40.79708029
76FER0.79481251
77PTK20.79429804
78CAMKK10.79294503
79DAPK10.77184041
80EPHA30.76971506
81EEF2K0.75527390
82MAP3K20.75306967
83PRKCG0.74879417
84BRSK20.74025152
85ROCK10.73797828
86NTRK20.71320719
87PRKD10.71212317
88MYLK0.70585786
89CDC42BPA0.69597623
90GSK3A0.69579036
91PRKAA10.69312954
92ROCK20.68474540
93TIE10.67129256
94CDK50.66688462
95AKT20.66508833
96MET0.65968325
97MKNK20.65026785
98DYRK1B0.64789663
99ERN10.63559843
100MAP2K60.62853694
101MAP3K130.62343977
102FGFR30.62219198
103FGFR40.61074043
104DAPK30.61035759
105STK380.60043618
106BRSK10.59443517
107CAMK40.59245655
108PAK30.58970971
109MAP2K10.57714506
110CDK140.57310793
111MAPK120.55941669
112PAK20.53992578
113CAMK2G0.53961333
114MST1R0.53936851
115AURKA0.52881699
116MAP3K60.52748959
117CAMK2A0.52694047
118PDK10.51303739
119SIK10.51268115
120ERBB30.51112423
121GRK70.50958418
122MAPK70.48948304
123RPS6KA20.47886646
124TSSK60.47198477
125KSR10.45708516
126MARK20.44472971
127PKN10.44143232
128EIF2AK30.43757120
129UHMK10.43274874
130MAPK40.43241242
131TLK10.42521838
132MOS0.42167624
133EPHB20.41625354
134PRKG20.40915463
135RAF10.40835665
136CDK180.40735748
137DYRK20.40592075
138TBK10.40485683
139ILK0.40304153
140PRKG10.39948483
141MARK30.39708482
142CDK150.39278222
143BLK0.38511938
144WNK40.37990318
145WEE10.37795175
146PRKD20.37069047
147STK110.36621648
148RET0.36467849
149SCYL20.36385395
150PTK2B0.33568493
151SGK10.33449214
152CDK11A0.33043639
153CSNK1A10.32275380
154TYRO30.32236929
155PRKCE0.31517750
156CAMK10.29833543
157FES0.28012108
158CAMK2B0.25595262

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.35460671
2Collecting duct acid secretion_Homo sapiens_hsa049663.84202772
3Proteasome_Homo sapiens_hsa030503.22471995
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.92065958
5Vibrio cholerae infection_Homo sapiens_hsa051102.40962383
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38229291
7Nicotine addiction_Homo sapiens_hsa050332.30346594
8Regulation of autophagy_Homo sapiens_hsa041402.20097643
9Complement and coagulation cascades_Homo sapiens_hsa046101.93982501
10Vitamin B6 metabolism_Homo sapiens_hsa007501.91131557
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89446319
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85682942
13GABAergic synapse_Homo sapiens_hsa047271.85228515
14Olfactory transduction_Homo sapiens_hsa047401.78799954
15Other glycan degradation_Homo sapiens_hsa005111.72404893
16Oxidative phosphorylation_Homo sapiens_hsa001901.69822461
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.69395175
18Dopaminergic synapse_Homo sapiens_hsa047281.69162430
19Amphetamine addiction_Homo sapiens_hsa050311.65686797
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64665839
21Long-term potentiation_Homo sapiens_hsa047201.62716484
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56755749
23Circadian entrainment_Homo sapiens_hsa047131.51985164
24Morphine addiction_Homo sapiens_hsa050321.51932934
25Fatty acid degradation_Homo sapiens_hsa000711.49087153
26Insulin secretion_Homo sapiens_hsa049111.48559209
27PPAR signaling pathway_Homo sapiens_hsa033201.45294823
28Arginine and proline metabolism_Homo sapiens_hsa003301.41657292
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37283828
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.34834291
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33927930
32Phenylalanine metabolism_Homo sapiens_hsa003601.29825335
33Glutamatergic synapse_Homo sapiens_hsa047241.28861739
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28753459
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.25877664
36Parkinsons disease_Homo sapiens_hsa050121.25505796
37Galactose metabolism_Homo sapiens_hsa000521.22516817
38Taste transduction_Homo sapiens_hsa047421.22475358
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21008762
40Bile secretion_Homo sapiens_hsa049761.19889210
41Lysosome_Homo sapiens_hsa041421.19192269
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15492561
43Salivary secretion_Homo sapiens_hsa049701.12225826
44Thyroid cancer_Homo sapiens_hsa052161.11246465
45Prion diseases_Homo sapiens_hsa050201.10551914
46Rheumatoid arthritis_Homo sapiens_hsa053231.09626592
47Cholinergic synapse_Homo sapiens_hsa047251.08901361
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07181683
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06068069
50Insulin signaling pathway_Homo sapiens_hsa049101.05582561
51Starch and sucrose metabolism_Homo sapiens_hsa005001.03190572
52GnRH signaling pathway_Homo sapiens_hsa049121.03148378
53Histidine metabolism_Homo sapiens_hsa003401.02527862
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.01873552
55Carbon metabolism_Homo sapiens_hsa012001.01064170
56Cocaine addiction_Homo sapiens_hsa050301.00734295
57Fatty acid metabolism_Homo sapiens_hsa012120.99707824
58Gastric acid secretion_Homo sapiens_hsa049710.98888781
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95543839
60Melanogenesis_Homo sapiens_hsa049160.95351651
61Glucagon signaling pathway_Homo sapiens_hsa049220.95167232
62Long-term depression_Homo sapiens_hsa047300.95035310
63Cardiac muscle contraction_Homo sapiens_hsa042600.92862399
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92439474
65Gap junction_Homo sapiens_hsa045400.91301277
66Tryptophan metabolism_Homo sapiens_hsa003800.91022114
67Calcium signaling pathway_Homo sapiens_hsa040200.90751832
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90262290
69Fructose and mannose metabolism_Homo sapiens_hsa000510.88575187
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88102378
71Focal adhesion_Homo sapiens_hsa045100.87957416
72Phagosome_Homo sapiens_hsa041450.86318415
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85069838
74Tyrosine metabolism_Homo sapiens_hsa003500.85011812
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82761297
76Sphingolipid metabolism_Homo sapiens_hsa006000.81473961
77Huntingtons disease_Homo sapiens_hsa050160.80453335
78Arginine biosynthesis_Homo sapiens_hsa002200.79393044
79Serotonergic synapse_Homo sapiens_hsa047260.79388989
80Dilated cardiomyopathy_Homo sapiens_hsa054140.78695445
81Sulfur metabolism_Homo sapiens_hsa009200.77935775
82Oxytocin signaling pathway_Homo sapiens_hsa049210.74836630
83Butanoate metabolism_Homo sapiens_hsa006500.74334098
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72785969
85ECM-receptor interaction_Homo sapiens_hsa045120.72282235
86Renin secretion_Homo sapiens_hsa049240.71597145
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.70838207
88Amoebiasis_Homo sapiens_hsa051460.69817098
89Alzheimers disease_Homo sapiens_hsa050100.69731798
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68806289
91Pyruvate metabolism_Homo sapiens_hsa006200.67777121
92beta-Alanine metabolism_Homo sapiens_hsa004100.65724877
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64149364
94Biosynthesis of amino acids_Homo sapiens_hsa012300.63617400
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61926758
96RNA polymerase_Homo sapiens_hsa030200.60474874
97Tight junction_Homo sapiens_hsa045300.59041494
98Pancreatic secretion_Homo sapiens_hsa049720.58446971
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58371788
100Oocyte meiosis_Homo sapiens_hsa041140.58165357
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57998072
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57528342
103cAMP signaling pathway_Homo sapiens_hsa040240.57453997
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57130677
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.56858438
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55732868
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55445953
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54661035
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54197079
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53362023
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53189321
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52406798
113Mineral absorption_Homo sapiens_hsa049780.51713250
114Peroxisome_Homo sapiens_hsa041460.50971800
115Pertussis_Homo sapiens_hsa051330.50766449
116Fatty acid elongation_Homo sapiens_hsa000620.48853992
117AMPK signaling pathway_Homo sapiens_hsa041520.47643968
118Propanoate metabolism_Homo sapiens_hsa006400.45699226
119Pentose phosphate pathway_Homo sapiens_hsa000300.45683573
120ABC transporters_Homo sapiens_hsa020100.45494458
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45062861
122Thyroid hormone synthesis_Homo sapiens_hsa049180.44314483
123VEGF signaling pathway_Homo sapiens_hsa043700.43801670
124Arachidonic acid metabolism_Homo sapiens_hsa005900.41998865
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41315781
126Fat digestion and absorption_Homo sapiens_hsa049750.41150820
127Nitrogen metabolism_Homo sapiens_hsa009100.40640819
128ErbB signaling pathway_Homo sapiens_hsa040120.40172147
129Proteoglycans in cancer_Homo sapiens_hsa052050.39598599
130Endocytosis_Homo sapiens_hsa041440.38122906
131Folate biosynthesis_Homo sapiens_hsa007900.37991889
132Estrogen signaling pathway_Homo sapiens_hsa049150.37943696
133Circadian rhythm_Homo sapiens_hsa047100.37744121
134Ovarian steroidogenesis_Homo sapiens_hsa049130.37662731
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37051776
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.36613231
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36144241
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35076117
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31391677
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.26087514
141Metabolic pathways_Homo sapiens_hsa011000.25091249
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24325424
143Insulin resistance_Homo sapiens_hsa049310.24047771

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