DUSP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.01819450
2serine transport (GO:0032329)5.48108223
3CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.41544775
4COPI coating of Golgi vesicle (GO:0048205)5.17487889
5Golgi transport vesicle coating (GO:0048200)5.17487889
6negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.73833960
7intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.99756949
8nuclear pore complex assembly (GO:0051292)3.94822097
9L-serine transport (GO:0015825)3.91787279
10pattern specification involved in kidney development (GO:0061004)3.80663784
11T cell lineage commitment (GO:0002360)3.69345834
12pre-miRNA processing (GO:0031054)3.62053406
13cell adhesion mediated by integrin (GO:0033627)3.59494694
14negative regulation of fatty acid transport (GO:2000192)3.56532375
15nuclear pore organization (GO:0006999)3.55234817
16positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.49987870
17sexual reproduction (GO:0019953)3.49508300
18regulation of translational fidelity (GO:0006450)3.48595058
19protein maturation by protein folding (GO:0022417)3.46169699
20tyrosine phosphorylation of STAT protein (GO:0007260)3.45799012
21regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.44939483
22positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.44939483
23heterochromatin organization (GO:0070828)3.44659570
24activation of MAPKKK activity (GO:0000185)3.44434343
25protein localization to microtubule (GO:0035372)3.42530118
26ganglion development (GO:0061548)3.36745688
27activation of Rac GTPase activity (GO:0032863)3.36683733
28axon extension (GO:0048675)3.33586036
29cellular copper ion homeostasis (GO:0006878)3.28850836
30NLS-bearing protein import into nucleus (GO:0006607)3.25230544
31endothelial cell chemotaxis (GO:0035767)3.23683264
32regulation of mammary gland epithelial cell proliferation (GO:0033599)3.22968835
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.22743138
34positive regulation of pseudopodium assembly (GO:0031274)3.20946153
35branching involved in mammary gland duct morphogenesis (GO:0060444)3.19047764
36positive regulation of axon extension (GO:0045773)3.18597451
37cellular response to nicotine (GO:0071316)3.12276356
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11202770
39melanin metabolic process (GO:0006582)3.10204501
40tolerance induction (GO:0002507)3.09619082
41ear development (GO:0043583)3.07335432
42regulation of interleukin-13 production (GO:0032656)3.06720800
43NIK/NF-kappaB signaling (GO:0038061)3.05827516
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.04545202
45endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.03776987
46regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.00236406
47nuclear envelope reassembly (GO:0031468)2.99136105
48mitotic nuclear envelope reassembly (GO:0007084)2.99136105
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96508643
50apoptotic process involved in morphogenesis (GO:0060561)2.93315958
51skin morphogenesis (GO:0043589)2.93307144
52muscle cell migration (GO:0014812)2.93190634
53folic acid-containing compound biosynthetic process (GO:0009396)2.92948814
54axon extension involved in axon guidance (GO:0048846)2.92110422
55neuron projection extension involved in neuron projection guidance (GO:1902284)2.92110422
56glomerular visceral epithelial cell development (GO:0072015)2.90510806
57modulation by symbiont of host cellular process (GO:0044068)2.87451010
58neuron projection extension (GO:1990138)2.84619575
59* endoderm formation (GO:0001706)2.84548248
60pore complex assembly (GO:0046931)2.84282841
61facial nerve structural organization (GO:0021612)2.84274135
62T cell apoptotic process (GO:0070231)2.82296365
63epithelial cell differentiation involved in prostate gland development (GO:0060742)2.77958959
64mRNA stabilization (GO:0048255)2.77710322
65RNA stabilization (GO:0043489)2.77710322
66interferon-gamma secretion (GO:0072643)2.77594963
67negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.76463523
68negative regulation of anoikis (GO:2000811)2.76217159
69mitotic nuclear envelope disassembly (GO:0007077)2.75059240
70protein retention in ER lumen (GO:0006621)2.74770467
71cellular response to virus (GO:0098586)2.74674358
72cell migration involved in sprouting angiogenesis (GO:0002042)2.73920985
73regulation of hippo signaling (GO:0035330)2.73818360
74mesodermal cell differentiation (GO:0048333)2.73533274
75mitotic G1/S transition checkpoint (GO:0044819)2.72892256
76regulation of translational termination (GO:0006449)2.72259680
77glucocorticoid receptor signaling pathway (GO:0042921)2.72258885
78regulation of anoikis (GO:2000209)2.71777511
79membrane disassembly (GO:0030397)2.70703887
80nuclear envelope disassembly (GO:0051081)2.70703887
81positive regulation of gamma-delta T cell activation (GO:0046645)2.69682019
82regulation of gamma-delta T cell differentiation (GO:0045586)2.68860231
83dosage compensation (GO:0007549)2.68534121
84regulation of pseudopodium assembly (GO:0031272)2.68234508
85melanin biosynthetic process (GO:0042438)2.66338771
86positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.66045293
87trophoblast giant cell differentiation (GO:0060707)2.65783436
88JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65476696
89positive regulation of histone deacetylation (GO:0031065)2.64298875
90retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64040414
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.63361741
92positive regulation of transcription regulatory region DNA binding (GO:2000679)2.63206899
93apoptotic process involved in development (GO:1902742)2.62733476
94regulation of RNA export from nucleus (GO:0046831)2.61409479
95epithelial cell-cell adhesion (GO:0090136)2.61153000
96positive regulation of SMAD protein import into nucleus (GO:0060391)2.59555482
97signal transduction in absence of ligand (GO:0038034)2.58861422
98extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.58861422
99respiratory tube development (GO:0030323)2.58202492
100establishment of spindle orientation (GO:0051294)2.57891642
101positive regulation of gene expression, epigenetic (GO:0045815)2.57170855
102peptidyl-lysine dimethylation (GO:0018027)2.56845524
103* inactivation of MAPK activity (GO:0000188)2.54593079
104negative regulation of histone methylation (GO:0031061)2.54451109
105cytoplasmic mRNA processing body assembly (GO:0033962)2.54057020
106sequestering of actin monomers (GO:0042989)2.53599392
107peptidyl-arginine omega-N-methylation (GO:0035247)2.53334906
108B cell homeostasis (GO:0001782)2.52414716
109glomerular epithelial cell development (GO:0072310)2.51663080
110regulation of early endosome to late endosome transport (GO:2000641)2.51280823
111dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51267169
112layer formation in cerebral cortex (GO:0021819)2.49739965
113establishment of mitotic spindle orientation (GO:0000132)2.49467323
114coronary vasculature morphogenesis (GO:0060977)2.49200475
115DNA unwinding involved in DNA replication (GO:0006268)2.48974215
116regulation of gamma-delta T cell activation (GO:0046643)2.48605433
117ER overload response (GO:0006983)2.47166507
118negative regulation of glycogen metabolic process (GO:0070874)2.46964020
119negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)2.46841499
120cell-cell junction maintenance (GO:0045217)2.46713401
121negative regulation of glycogen biosynthetic process (GO:0045719)2.46437357
122labyrinthine layer blood vessel development (GO:0060716)2.46337393
123regulation of chromatin binding (GO:0035561)2.46103626
124regulation of NFAT protein import into nucleus (GO:0051532)2.45640904
125endothelial tube morphogenesis (GO:0061154)2.45361259
126morphogenesis of an endothelium (GO:0003159)2.45361259
127protein localization to kinetochore (GO:0034501)2.45316151
128mitotic G1 DNA damage checkpoint (GO:0031571)2.45251814
129establishment of mitotic spindle localization (GO:0040001)2.45159824
130negative regulation of chondrocyte differentiation (GO:0032331)2.44723910
131myeloid dendritic cell differentiation (GO:0043011)2.44330408
132regulation of integrin activation (GO:0033623)2.44056388
133histone H2A monoubiquitination (GO:0035518)2.43910824
134neuron apoptotic process (GO:0051402)2.43378296
135regulation of SMAD protein import into nucleus (GO:0060390)2.42903934
136mitotic chromosome condensation (GO:0007076)2.42667471
137response to UV-C (GO:0010225)2.42544581
138negative regulation of ERBB signaling pathway (GO:1901185)2.42241442
139regulation of glucose import in response to insulin stimulus (GO:2001273)2.42182786
140skeletal muscle organ development (GO:0060538)2.41330153
141regulation of apoptotic process involved in morphogenesis (GO:1902337)2.40459683
142hippo signaling (GO:0035329)2.39377414
143positive thymic T cell selection (GO:0045059)2.38666088
144protein localization to endosome (GO:0036010)2.38625111
145peptidyl-arginine N-methylation (GO:0035246)2.38373658
146peptidyl-arginine methylation (GO:0018216)2.38373658
147positive regulation of natural killer cell differentiation (GO:0032825)2.38123766
148cellular senescence (GO:0090398)2.36213364
149vesicle coating (GO:0006901)2.36002611
150cellular response to arsenic-containing substance (GO:0071243)2.35950943
151regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.35259627
152nodal signaling pathway (GO:0038092)2.35021472
153trophectodermal cell differentiation (GO:0001829)2.34522604
154lymphocyte apoptotic process (GO:0070227)2.34441994
155G1 DNA damage checkpoint (GO:0044783)2.34246911
156semaphorin-plexin signaling pathway (GO:0071526)2.32347985
157regulation of posttranscriptional gene silencing (GO:0060147)2.28392210
158regulation of gene silencing by miRNA (GO:0060964)2.28392210
159regulation of gene silencing by RNA (GO:0060966)2.28392210
160cell-substrate junction assembly (GO:0007044)2.28225470
161diaphragm development (GO:0060539)2.28054029
162positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.27841027
163positive regulation of blood vessel endothelial cell migration (GO:0043536)2.27626000
164negative regulation of smooth muscle cell migration (GO:0014912)2.27229592
165adherens junction assembly (GO:0034333)2.26351091
166spliceosomal tri-snRNP complex assembly (GO:0000244)2.26241241
167polarized epithelial cell differentiation (GO:0030859)2.25734186
168hepatocyte apoptotic process (GO:0097284)2.25417736
169regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.24806210
170nuclear envelope organization (GO:0006998)2.24633545
171establishment of apical/basal cell polarity (GO:0035089)2.24265505
172cortical actin cytoskeleton organization (GO:0030866)2.23216029
173positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.22260328
174positive regulation of p38MAPK cascade (GO:1900745)2.20116916
175glial cell proliferation (GO:0014009)2.18757328
176placenta blood vessel development (GO:0060674)2.18691317
177decidualization (GO:0046697)2.18626993
178chromatin assembly (GO:0031497)2.18103435
179regulation of protein heterodimerization activity (GO:0043497)2.17583714
180regulation of podosome assembly (GO:0071801)2.17566487
181cytoskeletal anchoring at plasma membrane (GO:0007016)2.14785455
182growth hormone receptor signaling pathway (GO:0060396)2.14146855
183substrate-dependent cell migration (GO:0006929)2.13589515
184regulation of sister chromatid cohesion (GO:0007063)2.13478012
185negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.13400130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.91697783
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.75154350
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.71245116
4E2F7_22180533_ChIP-Seq_HELA_Human4.45534041
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.39327263
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36663181
7MYC_22102868_ChIP-Seq_BL_Human3.36238883
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.71181635
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39265838
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38442415
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20104901
12CLOCK_20551151_ChIP-Seq_293T_Human2.13753973
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11878347
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.11785009
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.11399014
16KDM2B_26808549_Chip-Seq_DND41_Human2.07811741
17VDR_21846776_ChIP-Seq_THP-1_Human2.06904903
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04118816
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.97122562
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92237975
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.91169845
22* ATF3_27146783_Chip-Seq_COLON_Human1.84192577
23ZNF263_19887448_ChIP-Seq_K562_Human1.84114872
24* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82824529
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.81824519
26* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81216374
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.75020454
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.74368736
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68465292
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.67661909
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65573841
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65561376
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64973560
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64655690
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62160933
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60544849
37* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59848514
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58052974
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57408652
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56692118
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52881106
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.52757544
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52096691
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51584345
45TFEB_21752829_ChIP-Seq_HELA_Human1.51362635
46* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49400945
47* MAF_26560356_Chip-Seq_TH1_Human1.47604356
48* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47122147
49* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45764167
50UTX_26944678_Chip-Seq_JUKART_Human1.44407996
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44100697
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43080976
53* KDM2B_26808549_Chip-Seq_JURKAT_Human1.42594022
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42242171
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.42065533
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42051465
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42051465
58* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39684865
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39396471
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38993586
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38467473
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38443133
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37072597
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34632682
65* RACK7_27058665_Chip-Seq_MCF-7_Human1.33451219
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31119011
67* UBF1/2_26484160_Chip-Seq_HMECs_Human1.30673892
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30586951
69* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.30582224
70* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29410684
71* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28894224
72* VDR_24763502_ChIP-Seq_THP-1_Human1.28397915
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.27892332
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26848661
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.24960417
76* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24948414
77* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23173834
78KDM2B_26808549_Chip-Seq_K562_Human1.22924115
79AR_21909140_ChIP-Seq_LNCAP_Human1.21166827
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.21067912
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20651731
82TP53_22127205_ChIP-Seq_IMR90_Human1.19546394
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19199801
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18951388
85NCOR1_26117541_ChIP-Seq_K562_Human1.16403834
86XRN2_22483619_ChIP-Seq_HELA_Human1.15316377
87MYB_26560356_Chip-Seq_TH2_Human1.14756847
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14449985
89* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14330340
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.14212521
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14184646
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14091760
93BRD4_25478319_ChIP-Seq_HGPS_Human1.13812718
94CHD1_26751641_Chip-Seq_LNCaP_Human1.13063120
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11963483
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10982854
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09948938
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09690608
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09614881
100MYB_26560356_Chip-Seq_TH1_Human1.07956671
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06788029
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06410111
103* LXR_22292898_ChIP-Seq_THP-1_Human1.06152111
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05412920
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05072548
106* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05003137
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04325863
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04240621
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03201601
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03199430
111YY1_21170310_ChIP-Seq_MESCs_Mouse1.03054761
112* E2F1_21310950_ChIP-Seq_MCF-7_Human1.02634737
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02606423
114CIITA_25753668_ChIP-Seq_RAJI_Human1.01133867
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99469477
116ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99338582
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.98247965
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97903110
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.97818848
120* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97683363
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97609142
122* GATA6_25053715_ChIP-Seq_YYC3_Human0.96394426
123MAF_26560356_Chip-Seq_TH2_Human0.96266989
124THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96108593
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93950376
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93546530
127* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93314509
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90080305
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.89924829
130DCP1A_22483619_ChIP-Seq_HELA_Human0.88039050
131* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87826974
132* CREB1_26743006_Chip-Seq_LNCaP_Human0.86456461
133MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86352254
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86309295
135* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86039425
136P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84759520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.68697602
2MP0005076_abnormal_cell_differentiation3.40339812
3MP0000569_abnormal_digit_pigmentation3.16497725
4MP0003705_abnormal_hypodermis_morpholog2.77318546
5MP0000566_synostosis2.69037759
6MP0000579_abnormal_nail_morphology2.54086473
7MP0003300_gastrointestinal_ulcer2.51947602
8MP0002877_abnormal_melanocyte_morpholog2.51085506
9MP0005408_hypopigmentation2.39362632
10MP0003566_abnormal_cell_adhesion2.28249663
11MP0010307_abnormal_tumor_latency2.26100104
12MP0000733_abnormal_muscle_development2.08753774
13MP0003091_abnormal_cell_migration2.02108061
14MP0010234_abnormal_vibrissa_follicle2.01665405
15MP0000537_abnormal_urethra_morphology1.94810884
16MP0004381_abnormal_hair_follicle1.93803655
17MP0003315_abnormal_perineum_morphology1.92000699
18MP0005257_abnormal_intraocular_pressure1.88397488
19MP0003303_peritoneal_inflammation1.84301342
20MP0008961_abnormal_basal_metabolism1.75516568
21MP0005623_abnormal_meninges_morphology1.73288738
22MP0005409_darkened_coat_color1.71559766
23MP0005171_absent_coat_pigmentation1.68685627
24MP0001849_ear_inflammation1.66385381
25MP0002254_reproductive_system_inflammat1.62389952
26MP0001216_abnormal_epidermal_layer1.61245681
27MP0003329_amyloid_beta_deposits1.59614224
28MP0002177_abnormal_outer_ear1.57982241
29MP0005023_abnormal_wound_healing1.57857573
30MP0001348_abnormal_lacrimal_gland1.56515946
31MP0009278_abnormal_bone_marrow1.56415032
32MP0004197_abnormal_fetal_growth/weight/1.56275780
33MP0005501_abnormal_skin_physiology1.55283768
34MP0003111_abnormal_nucleus_morphology1.54902812
35MP0003436_decreased_susceptibility_to1.54279250
36MP0001346_abnormal_lacrimal_gland1.53800053
37MP0003077_abnormal_cell_cycle1.52336550
38MP0002006_tumorigenesis1.51110484
39MP0000350_abnormal_cell_proliferation1.49418100
40MP0003172_abnormal_lysosome_physiology1.47749120
41MP0008007_abnormal_cellular_replicative1.47320059
42MP0000858_altered_metastatic_potential1.45635432
43MP0003123_paternal_imprinting1.43913789
44MP0001730_embryonic_growth_arrest1.43140446
45MP0000371_diluted_coat_color1.42815996
46MP0000467_abnormal_esophagus_morphology1.42399956
47MP0005423_abnormal_somatic_nervous1.40687341
48MP0000762_abnormal_tongue_morphology1.39008765
49MP0003693_abnormal_embryo_hatching1.38556316
50MP0001873_stomach_inflammation1.35675950
51MP0000372_irregular_coat_pigmentation1.33586731
52MP0000685_abnormal_immune_system1.33182048
53MP0002084_abnormal_developmental_patter1.32039884
54MP0003448_altered_tumor_morphology1.31686888
55MP0002088_abnormal_embryonic_growth/wei1.30559380
56MP0002138_abnormal_hepatobiliary_system1.30301188
57MP0002166_altered_tumor_susceptibility1.30044441
58MP0004808_abnormal_hematopoietic_stem1.26487767
59MP0001672_abnormal_embryogenesis/_devel1.25833308
60MP0005380_embryogenesis_phenotype1.25833308
61MP0003984_embryonic_growth_retardation1.25797994
62MP0000003_abnormal_adipose_tissue1.24655428
63MP0003453_abnormal_keratinocyte_physiol1.22110618
64MP0000751_myopathy1.19704462
65MP0002086_abnormal_extraembryonic_tissu1.17453505
66MP0002796_impaired_skin_barrier1.17395444
67MP0004957_abnormal_blastocyst_morpholog1.16997986
68MP0004947_skin_inflammation1.16923616
69MP0002085_abnormal_embryonic_tissue1.16530136
70MP0001697_abnormal_embryo_size1.16340025
71MP0001881_abnormal_mammary_gland1.15473308
72MP0000778_abnormal_nervous_system1.13660281
73MP0005499_abnormal_olfactory_system1.13566716
74MP0005394_taste/olfaction_phenotype1.13566716
75MP0004272_abnormal_basement_membrane1.13384710
76MP0008789_abnormal_olfactory_epithelium1.12926202
77MP0003890_abnormal_embryonic-extraembry1.11079268
78MP0000703_abnormal_thymus_morphology1.10529726
79MP0005197_abnormal_uvea_morphology1.09911750
80MP0002653_abnormal_ependyma_morphology1.09153493
81MP0002060_abnormal_skin_morphology1.08361618
82MP0000377_abnormal_hair_follicle1.07778992
83MP0003763_abnormal_thymus_physiology1.07761021
84MP0003385_abnormal_body_wall1.07202109
85MP0004858_abnormal_nervous_system1.07052265
86MP0002098_abnormal_vibrissa_morphology1.06834081
87MP0002405_respiratory_system_inflammati1.06592677
88MP0001915_intracranial_hemorrhage1.06504817
89MP0002184_abnormal_innervation1.06496623
90MP0009053_abnormal_anal_canal1.06409007
91MP0001727_abnormal_embryo_implantation1.05635981
92MP0010030_abnormal_orbit_morphology1.04778916
93MP0002080_prenatal_lethality1.04276731
94MP0002396_abnormal_hematopoietic_system1.02693604
95MP0009333_abnormal_splenocyte_physiolog1.02426038
96MP0001340_abnormal_eyelid_morphology1.02207051
97MP0001186_pigmentation_phenotype1.02025354
98MP0000534_abnormal_ureter_morphology1.01661086
99MP0003115_abnormal_respiratory_system1.01194160
100MP0005451_abnormal_body_composition1.01189851
101MP0008932_abnormal_embryonic_tissue1.00691989
102MP0004510_myositis1.00545132
103MP0002092_abnormal_eye_morphology0.99208512
104MP0001879_abnormal_lymphatic_vessel0.98640334
105MP0003567_abnormal_fetal_cardiomyocyte0.98267579
106MP0009840_abnormal_foam_cell0.98146776
107MP0008770_decreased_survivor_rate0.96924342
108MP0000627_abnormal_mammary_gland0.96277100
109MP0000490_abnormal_crypts_of0.95641350
110MP0005621_abnormal_cell_physiology0.95448170
111MP0003942_abnormal_urinary_system0.94984398
112MP0002163_abnormal_gland_morphology0.94947669
113MP0002075_abnormal_coat/hair_pigmentati0.94613502
114MP0002697_abnormal_eye_size0.92954145
115MP0000428_abnormal_craniofacial_morphol0.92944650
116MP0002925_abnormal_cardiovascular_devel0.92640822
117MP0001299_abnormal_eye_distance/0.90480073
118MP0005248_abnormal_Harderian_gland0.88940115
119MP0004233_abnormal_muscle_weight0.88806071
120MP0004185_abnormal_adipocyte_glucose0.88247976
121MP0004264_abnormal_extraembryonic_tissu0.87466101
122MP0003045_fibrosis0.87242624
123MP0001790_abnormal_immune_system0.87134883
124MP0005387_immune_system_phenotype0.87134883
125MP0000015_abnormal_ear_pigmentation0.87134549
126MP0002933_joint_inflammation0.86941227
127MP0000613_abnormal_salivary_gland0.86064103
128MP0003866_abnormal_defecation0.85457652
129MP0002896_abnormal_bone_mineralization0.84191741
130MP0000750_abnormal_muscle_regeneration0.81461288
131MP0002089_abnormal_postnatal_growth/wei0.81363267
132MP0002751_abnormal_autonomic_nervous0.79547519
133MP0000367_abnormal_coat/_hair0.79218222
134MP0008438_abnormal_cutaneous_collagen0.77786023
135MP0001502_abnormal_circadian_rhythm0.77764432
136MP0005384_cellular_phenotype0.77517665
137MP0010678_abnormal_skin_adnexa0.77471995
138MP0001545_abnormal_hematopoietic_system0.76915037
139MP0005397_hematopoietic_system_phenotyp0.76915037
140MP0003959_abnormal_lean_body0.76603666
141MP0010094_abnormal_chromosome_stability0.76358690
142MP0002398_abnormal_bone_marrow0.75969949
143MP0010771_integument_phenotype0.75882865
144MP0002332_abnormal_exercise_endurance0.75751186
145MP0010155_abnormal_intestine_physiology0.75135769
146MP0009931_abnormal_skin_appearance0.74712240
147MP0002111_abnormal_tail_morphology0.73896567
148MP0001958_emphysema0.73705917
149MP0000477_abnormal_intestine_morphology0.73360582
150MP0003191_abnormal_cellular_cholesterol0.73026390
151MP0001800_abnormal_humoral_immune0.70677913
152MP0000432_abnormal_head_morphology0.70082046
153MP0005193_abnormal_anterior_eye0.69858291
154MP0005165_increased_susceptibility_to0.69431734
155MP0005000_abnormal_immune_tolerance0.69068450
156MP0003861_abnormal_nervous_system0.68615082
157MP0003119_abnormal_digestive_system0.68158913
158MP0003950_abnormal_plasma_membrane0.62641741

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)4.20243772
2Onycholysis (HP:0001806)4.04799893
3Entropion (HP:0000621)3.82886889
4Persistence of primary teeth (HP:0006335)3.47937044
5Gastrointestinal stroma tumor (HP:0100723)3.31539481
6Subacute progressive viral hepatitis (HP:0006572)3.15192827
7Fragile nails (HP:0001808)3.14574983
8Nail dystrophy (HP:0008404)3.12792798
9Insomnia (HP:0100785)3.10610754
10IgA deficiency (HP:0002720)3.08960556
11Cerebral aneurysm (HP:0004944)3.07584373
12Ridged nail (HP:0001807)3.03846388
13Shallow orbits (HP:0000586)2.93239834
14Poikiloderma (HP:0001029)2.85847440
15Neurofibrillary tangles (HP:0002185)2.82358676
16Hyperacusis (HP:0010780)2.75973457
17Arterial tortuosity (HP:0005116)2.75522932
18Plantar hyperkeratosis (HP:0007556)2.67766648
19Cerebral inclusion bodies (HP:0100314)2.64489929
20Natal tooth (HP:0000695)2.57789466
21Short 4th metacarpal (HP:0010044)2.57140268
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57140268
23Aplasia cutis congenita (HP:0001057)2.49787886
24Abnormality of the distal phalanges of the toes (HP:0010182)2.42281508
25Distal upper limb amyotrophy (HP:0007149)2.40490148
26Upper limb amyotrophy (HP:0009129)2.40490148
27Achilles tendon contracture (HP:0001771)2.39385645
28Reduced subcutaneous adipose tissue (HP:0003758)2.37388370
29Overriding aorta (HP:0002623)2.34949220
30Thick nail (HP:0001805)2.34024742
31Deviation of the thumb (HP:0009603)2.33553072
32Hand muscle atrophy (HP:0009130)2.29204925
33Abnormality of nail color (HP:0100643)2.27397417
34High anterior hairline (HP:0009890)2.25562073
35Micronodular cirrhosis (HP:0001413)2.21167112
36Abnormality of the astrocytes (HP:0100707)2.19152904
37Astrocytoma (HP:0009592)2.19152904
38Multiple lipomas (HP:0001012)2.16912427
39Heterotopia (HP:0002282)2.16790929
40Pelvic girdle muscle weakness (HP:0003749)2.15411729
41Sparse scalp hair (HP:0002209)2.14227810
42Vertebral compression fractures (HP:0002953)2.13999417
43Deep palmar crease (HP:0006191)2.13174279
44Long toe (HP:0010511)2.10611163
45Macroorchidism (HP:0000053)2.10172418
46Akinesia (HP:0002304)2.09916162
47Cutaneous melanoma (HP:0012056)2.08688574
48Proximal placement of thumb (HP:0009623)2.06322000
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05801278
50Flattened epiphyses (HP:0003071)2.04677258
51Dilatation of the ascending aorta (HP:0005111)2.04281148
52Peripheral hypomyelination (HP:0007182)2.03170566
5311 pairs of ribs (HP:0000878)2.01219969
54Radial bowing (HP:0002986)2.00612812
55Overlapping toe (HP:0001845)2.00388351
56Vascular tortuosity (HP:0004948)2.00132074
57Hypotrichosis (HP:0001006)1.99706215
58Hyperparathyroidism (HP:0000843)1.99365715
59Abnormality of the calcaneus (HP:0008364)1.98516238
60Squamous cell carcinoma (HP:0002860)1.98312533
61Premature rupture of membranes (HP:0001788)1.97362364
62Aortic aneurysm (HP:0004942)1.96438760
63Distal lower limb amyotrophy (HP:0008944)1.94548864
64Down-sloping shoulders (HP:0200021)1.94507172
65Glucose intolerance (HP:0000833)1.94251781
66Difficulty climbing stairs (HP:0003551)1.94146223
67Hypopigmentation of the fundus (HP:0007894)1.94023684
68Heterochromia iridis (HP:0001100)1.92803127
69Genu recurvatum (HP:0002816)1.92279893
70Hypercortisolism (HP:0001578)1.91730522
71Abnormality of oral frenula (HP:0000190)1.90887000
72Autoamputation (HP:0001218)1.90183220
73Protrusio acetabuli (HP:0003179)1.89769909
74Abnormality of the Achilles tendon (HP:0005109)1.89360287
75Mitral valve prolapse (HP:0001634)1.88764434
76Ependymoma (HP:0002888)1.87792429
77Spinal cord compression (HP:0002176)1.87368996
78Shoulder girdle muscle weakness (HP:0003547)1.87216039
79Cervical subluxation (HP:0003308)1.86848673
80Wrist flexion contracture (HP:0001239)1.86542465
81Bicornuate uterus (HP:0000813)1.86054502
82Long palpebral fissure (HP:0000637)1.84903573
83Diminished motivation (HP:0000745)1.84633694
84Flat acetabular roof (HP:0003180)1.84381107
85Ureteral stenosis (HP:0000071)1.84021223
86Glossoptosis (HP:0000162)1.83993239
87Absent frontal sinuses (HP:0002688)1.83132903
88Tetraparesis (HP:0002273)1.83077389
89Bowel diverticulosis (HP:0005222)1.82904682
90Increased connective tissue (HP:0009025)1.82299115
91Apathy (HP:0000741)1.81396082
92Abnormality of the anterior horn cell (HP:0006802)1.80709881
93Degeneration of anterior horn cells (HP:0002398)1.80709881
94Ulnar bowing (HP:0003031)1.78638793
95Malignant gastrointestinal tract tumors (HP:0006749)1.78592351
96Gastrointestinal carcinoma (HP:0002672)1.78592351
97Fatigue (HP:0012378)1.78384027
98Enlarged penis (HP:0000040)1.77826801
99Broad face (HP:0000283)1.76867025
100Aneurysm (HP:0002617)1.76631468
101Atrophic scars (HP:0001075)1.76553013
102Progressive sensorineural hearing impairment (HP:0000408)1.75975418
103Osteolytic defects of the hand bones (HP:0009699)1.75839522
104Osteolytic defects of the phalanges of the hand (HP:0009771)1.75839522
105Focal segmental glomerulosclerosis (HP:0000097)1.75450822
106Conjugated hyperbilirubinemia (HP:0002908)1.74620152
107Abnormality of the musculature of the pelvis (HP:0001469)1.73953346
108Abnormality of the hip-girdle musculature (HP:0001445)1.73953346
109Pointed chin (HP:0000307)1.73286713
110Abnormality of the 4th metacarpal (HP:0010012)1.72414401
111Ureteral obstruction (HP:0006000)1.72320948
112Short nail (HP:0001799)1.72201329
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72144178
114Abnormality of the gastric mucosa (HP:0004295)1.72103862
115Adrenal hypoplasia (HP:0000835)1.71336726
116Spinal muscular atrophy (HP:0007269)1.71053616
117Supranuclear gaze palsy (HP:0000605)1.70081476
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69094873
119Open mouth (HP:0000194)1.68947610
120Bilateral sensorineural hearing impairment (HP:0008619)1.68693460
121Interstitial pulmonary disease (HP:0006530)1.68545006
122Hypoplasia of dental enamel (HP:0006297)1.68382033
123Trigonocephaly (HP:0000243)1.68345537
124Lip pit (HP:0100267)1.67755289
125Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67132703
126Hypoplasia of the brainstem (HP:0002365)1.67132703
127Thin bony cortex (HP:0002753)1.66203990
128Milia (HP:0001056)1.66063197
129Distal sensory impairment (HP:0002936)1.65836898
130Decreased motor nerve conduction velocity (HP:0003431)1.65041662
131Skull defect (HP:0001362)1.64278535
132Viral hepatitis (HP:0006562)1.64214329
133Abnormality of the nasal septum (HP:0000419)1.63633769
134Bronchomalacia (HP:0002780)1.63436247
135Trismus (HP:0000211)1.63236479
136Renal duplication (HP:0000075)1.62850615
137Turricephaly (HP:0000262)1.62721290
138Increased nuchal translucency (HP:0010880)1.62691388
139Increased cerebral lipofuscin (HP:0011813)1.62112035
140Upper limb muscle weakness (HP:0003484)1.61638880
141Septate vagina (HP:0001153)1.61602308
142Hypoplastic toenails (HP:0001800)1.61564870
143Acanthosis nigricans (HP:0000956)1.61295791
144Small epiphyses (HP:0010585)1.61217574
145Megalocornea (HP:0000485)1.60986500
146Missing ribs (HP:0000921)1.60953114
147Arnold-Chiari malformation (HP:0002308)1.60642231
148Urethral obstruction (HP:0000796)1.60545172
149Myocardial infarction (HP:0001658)1.60245282
150Broad thumb (HP:0011304)1.59723060
151Spinal cord lesions (HP:0100561)1.59534485
152Syringomyelia (HP:0003396)1.59534485
153Vertebral arch anomaly (HP:0008438)1.59496478
154Somatic mutation (HP:0001428)1.59263763
155Alopecia of scalp (HP:0002293)1.59044512
156Lower limb amyotrophy (HP:0007210)1.58307581
157Anal stenosis (HP:0002025)1.58071093
158Selective tooth agenesis (HP:0001592)1.57974060
159Limb-girdle muscle atrophy (HP:0003797)1.57280460
160Deviation of the hallux (HP:0010051)1.57155860
161Abnormal blistering of the skin (HP:0008066)1.57117895
162Broad nasal tip (HP:0000455)1.56702197
163Elfin facies (HP:0004428)1.55845410
164Hallux valgus (HP:0001822)1.55661774
165Camptodactyly of toe (HP:0001836)1.55594145
166Leiomyosarcoma (HP:0100243)1.55453579
167Uterine leiomyosarcoma (HP:0002891)1.55453579
168Scapular winging (HP:0003691)1.54453708
169Progressive hearing impairment (HP:0001730)1.53582007
170Glioma (HP:0009733)1.51733739
171Bladder diverticulum (HP:0000015)1.50568458
172Esophageal varix (HP:0002040)1.50427170
173Termporal pattern (HP:0011008)1.49919082
174Insidious onset (HP:0003587)1.49919082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.75940145
2EEF2K3.59634789
3TRIB33.57099606
4PKN22.84848582
5CDK122.75636978
6SCYL22.62472089
7TTN2.55240170
8LMTK22.54778350
9PRPF4B2.41793535
10STK162.27613099
11IRAK32.27067864
12ARAF2.12248986
13MAP3K101.94366680
14PTK61.88620298
15SIK11.87696449
16JAK31.86821000
17ERBB41.79775600
18STK241.77282755
19ALK1.74209903
20NTRK11.64641811
21PDGFRA1.60304933
22SMG11.54454042
23BMX1.54099691
24NEK21.48431626
25MTOR1.45972560
26CHUK1.45766937
27EPHA31.40815055
28PTK21.39954702
29NEK11.39204992
30MAP4K11.38438402
31FGFR41.36552433
32MAP2K71.34314011
33PAK41.33924459
34STK101.29795198
35TSSK61.28945133
36LRRK21.28322989
37RIPK11.27605575
38ICK1.27075093
39MAP3K141.20761962
40CDK61.20218638
41PAK21.19917274
42TESK11.16932459
43SIK21.14345530
44LATS11.14294756
45RPS6KB21.13217465
46RPS6KA41.07698497
47CDC71.05330167
48PASK1.05095091
49FGFR11.04742157
50ZAP701.04253892
51EPHB11.03722385
52BRD41.02369095
53TYRO31.01774026
54MAP3K81.01519552
55PDGFRB0.99447348
56DDR20.99115399
57ITK0.98473958
58KSR10.98461659
59MAP3K90.97229321
60FER0.96220240
61TBK10.94944194
62CAMK1D0.92394676
63FGFR30.84219619
64SIK30.84167316
65RET0.83704799
66EPHB20.82555014
67TGFBR10.80529037
68MAP3K110.80133541
69PRKCI0.79760954
70DYRK1B0.78987025
71CAMK1G0.78019917
72MOS0.77703296
73PHKG20.74981536
74PHKG10.74981536
75TAOK10.74944717
76MKNK20.73597204
77HCK0.72830571
78MET0.70689836
79MARK10.69616615
80ROCK20.69531874
81CDK80.69334802
82MAP3K130.69009432
83AURKA0.68651890
84TESK20.67683639
85CASK0.67135786
86IKBKB0.62963378
87MARK30.62887923
88TXK0.62226330
89BCR0.61925674
90MAP3K30.61668456
91CDK40.61083527
92EGFR0.60954436
93DYRK30.60451757
94BRAF0.57925379
95DMPK0.57305333
96LATS20.57291118
97CHEK10.56914216
98ABL20.56375872
99ERBB20.54392626
100MST1R0.54336446
101CDK140.53893672
102ILK0.52978724
103GSK3A0.52327792
104PIM10.51915359
105STK30.51594229
106RPS6KA20.51522599
107MAPK110.50657257
108TAF10.49514671
109MELK0.48872914
110CDK11A0.48251389
111TAOK20.47468540
112INSR0.46561236
113CDK180.45724099
114CDK150.44843799
115MAPKAPK20.43739040
116WEE10.42838514
117MATK0.42366114
118NEK90.42347941
119ERBB30.41938585
120CDK20.41887129
121MAPK90.41749939
122RPS6KA10.41739225
123PAK10.41614620
124HIPK20.40772868
125LCK0.40264132
126LIMK10.39817075
127PIM20.39150808
128CDK70.39012451
129MAP2K30.38971814
130MAP2K20.38683427
131ATR0.38376593
132ERN10.38153048
133AURKB0.37833655
134MARK20.37622301
135NME20.37496400
136JAK10.37442446
137CDK90.36700607
138MAP3K20.36263706
139EIF2AK20.35466843
140BUB10.35332171
141CDC42BPA0.29645119
142MAPKAPK50.29297355
143CHEK20.28923277
144CSF1R0.28542473
145TLK10.27606477
146AKT20.26942766
147STK38L0.26466222
148PRKCH0.26085412
149EIF2AK30.26007518

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.32292641
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.08755932
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.99256025
4MicroRNAs in cancer_Homo sapiens_hsa052061.88387317
5Small cell lung cancer_Homo sapiens_hsa052221.80819871
6Proteoglycans in cancer_Homo sapiens_hsa052051.59280008
7mTOR signaling pathway_Homo sapiens_hsa041501.57619388
8Viral myocarditis_Homo sapiens_hsa054161.54803104
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54667243
10T cell receptor signaling pathway_Homo sapiens_hsa046601.53898604
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52776028
12Adherens junction_Homo sapiens_hsa045201.52693096
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.51520679
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.45655330
15Viral carcinogenesis_Homo sapiens_hsa052031.44512429
16Bladder cancer_Homo sapiens_hsa052191.42768019
17Colorectal cancer_Homo sapiens_hsa052101.42736240
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.42468658
19HTLV-I infection_Homo sapiens_hsa051661.41440594
20Pancreatic cancer_Homo sapiens_hsa052121.41419551
21Acute myeloid leukemia_Homo sapiens_hsa052211.40364203
22Renal cell carcinoma_Homo sapiens_hsa052111.39128593
23Endometrial cancer_Homo sapiens_hsa052131.38115110
24Allograft rejection_Homo sapiens_hsa053301.36454636
25Shigellosis_Homo sapiens_hsa051311.36163552
26Osteoclast differentiation_Homo sapiens_hsa043801.35808203
27Toxoplasmosis_Homo sapiens_hsa051451.35518968
28Apoptosis_Homo sapiens_hsa042101.34976899
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33117350
30Axon guidance_Homo sapiens_hsa043601.32377056
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.32328149
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32189157
33Prolactin signaling pathway_Homo sapiens_hsa049171.31676667
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31572268
35RNA transport_Homo sapiens_hsa030131.31255829
36TNF signaling pathway_Homo sapiens_hsa046681.29877244
37Leishmaniasis_Homo sapiens_hsa051401.29646258
38Hippo signaling pathway_Homo sapiens_hsa043901.29156795
39p53 signaling pathway_Homo sapiens_hsa041151.26559624
40Focal adhesion_Homo sapiens_hsa045101.26011897
41Antigen processing and presentation_Homo sapiens_hsa046121.25287528
42Measles_Homo sapiens_hsa051621.22556217
43Notch signaling pathway_Homo sapiens_hsa043301.22234666
44Hepatitis B_Homo sapiens_hsa051611.20249792
45Alcoholism_Homo sapiens_hsa050341.15005317
46Glioma_Homo sapiens_hsa052141.14482576
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14304590
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14191302
49HIF-1 signaling pathway_Homo sapiens_hsa040661.14078970
50B cell receptor signaling pathway_Homo sapiens_hsa046621.13700594
51Autoimmune thyroid disease_Homo sapiens_hsa053201.12936708
52Epstein-Barr virus infection_Homo sapiens_hsa051691.12262954
53Non-small cell lung cancer_Homo sapiens_hsa052231.11267706
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.09670715
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07947473
56VEGF signaling pathway_Homo sapiens_hsa043701.07695429
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05709703
58Cell cycle_Homo sapiens_hsa041101.05208680
59N-Glycan biosynthesis_Homo sapiens_hsa005101.01562148
60Asthma_Homo sapiens_hsa053101.00998717
61Jak-STAT signaling pathway_Homo sapiens_hsa046301.00945005
62Prostate cancer_Homo sapiens_hsa052151.00144435
63One carbon pool by folate_Homo sapiens_hsa006700.99618242
64Vibrio cholerae infection_Homo sapiens_hsa051100.98681034
65Basal cell carcinoma_Homo sapiens_hsa052170.97905087
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97472020
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97010570
68Legionellosis_Homo sapiens_hsa051340.96713203
69mRNA surveillance pathway_Homo sapiens_hsa030150.95876219
70Thyroid cancer_Homo sapiens_hsa052160.93491460
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91211812
72Amoebiasis_Homo sapiens_hsa051460.90585791
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89984580
74Systemic lupus erythematosus_Homo sapiens_hsa053220.88859173
75ErbB signaling pathway_Homo sapiens_hsa040120.88706522
76Pathways in cancer_Homo sapiens_hsa052000.87974605
77Spliceosome_Homo sapiens_hsa030400.87445811
78Melanoma_Homo sapiens_hsa052180.86962063
79TGF-beta signaling pathway_Homo sapiens_hsa043500.86265990
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85637003
81ECM-receptor interaction_Homo sapiens_hsa045120.82578228
82Cocaine addiction_Homo sapiens_hsa050300.82523527
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81771642
84Melanogenesis_Homo sapiens_hsa049160.81664877
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81527701
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81509667
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80916516
88Salmonella infection_Homo sapiens_hsa051320.80702377
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80652072
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77595338
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77064715
92Sulfur relay system_Homo sapiens_hsa041220.76971601
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76474353
94Type I diabetes mellitus_Homo sapiens_hsa049400.76350003
95Influenza A_Homo sapiens_hsa051640.75732641
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75142380
97Endocytosis_Homo sapiens_hsa041440.74565285
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74436769
99FoxO signaling pathway_Homo sapiens_hsa040680.73420768
100Graft-versus-host disease_Homo sapiens_hsa053320.73377773
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.73009241
102Nucleotide excision repair_Homo sapiens_hsa034200.70355278
103Tight junction_Homo sapiens_hsa045300.69912868
104Herpes simplex infection_Homo sapiens_hsa051680.68869132
105Insulin resistance_Homo sapiens_hsa049310.68417725
106GnRH signaling pathway_Homo sapiens_hsa049120.68332219
107Estrogen signaling pathway_Homo sapiens_hsa049150.68029373
108Type II diabetes mellitus_Homo sapiens_hsa049300.66951189
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66499909
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66034546
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65415292
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64982946
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.64865920
114AMPK signaling pathway_Homo sapiens_hsa041520.64738405
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63958351
116Hedgehog signaling pathway_Homo sapiens_hsa043400.63913624
117Tuberculosis_Homo sapiens_hsa051520.63090249
118Rap1 signaling pathway_Homo sapiens_hsa040150.62231854
119Hepatitis C_Homo sapiens_hsa051600.61890201
120Insulin signaling pathway_Homo sapiens_hsa049100.61766505
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61113953
122* MAPK signaling pathway_Homo sapiens_hsa040100.60966805
123Fructose and mannose metabolism_Homo sapiens_hsa000510.60791322
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60418196
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60111164
126Primary immunodeficiency_Homo sapiens_hsa053400.59240350
127Wnt signaling pathway_Homo sapiens_hsa043100.57631738
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56568921
129Dilated cardiomyopathy_Homo sapiens_hsa054140.52809549
130Sphingolipid metabolism_Homo sapiens_hsa006000.51843847

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